Mol
ecul
esPr
otei
ns, c
arbo
hydr
ates
, fat
s, n
ucle
ic a
cids
Org
anel
les
Cel
lsFu
nctio
nal u
nits
Tiss
ues
Org
ans
Org
an s
yste
ms
Body
Ana
tom
y an
d Ph
ysio
logy
-Ant
erio
r (ve
ntra
l) vi
ew-L
ater
al v
iew
-Pos
terio
r (do
rsal
) vie
w
-Ana
tom
ical
pla
nes
Reg
ions
: -A
xial
-App
endi
cula
r (ex
trem
ities
)
Body
cav
ities
:-D
orsa
l (cr
ania
l and
spi
nal),
-v
entra
l (th
orac
ic a
nd a
bdom
inop
elvi
c),
-nas
al, o
ral,
orbi
tal,
tym
pani
c, a
nd s
ynov
ial
Prox
imal
–C
lose
rto
the
cent
erof
the
body
Dis
tal–
Furt
herf
rom
the
cent
erof
the
body
Supe
rfic
ial–
Clo
sert
oth
esk
inD
eep
–Fu
rthe
rfro
mth
esk
in
Dor
sal–
Tow
ards
the
back
ofth
ebo
dyVe
ntra
l–To
war
dsth
efr
onto
fthe
body
Pron
ate
–Tu
rnth
epa
lms
upor
the
feet
inw
ard
Supi
nate
–Tu
rnth
epa
lms
dow
nor
the
feet
outw
ard
Abdu
ctio
n–
Tom
ove
away
from
the
mid
dle
ofth
ebo
dyAd
duct
ion
–To
mov
eto
war
dth
em
iddl
eof
the
body
Exte
nsio
n–
Tost
raig
hten
outa
join
tFl
exio
n–
Tobe
nda
join
t
Dor
sifle
xion
–To
bend
the
foot
upw
ard
atth
ean
kle
Plan
tarf
lexi
on–
Tobe
ndth
efo
otdo
wnw
ard
atth
ean
kle
Cra
nial
–C
lose
rto
the
head
Cau
dal–
Clo
sert
oth
ebu
ttock
s
Fora
men
–A
hole
orop
enin
gFo
ssa
–A
flats
urfa
ceor
ade
pres
sion
.Lu
men
–Th
eop
enin
gof
atu
be(li
keth
ece
nter
ofth
ew
indp
ipe
ora
bloo
dve
ssel
).Pr
omin
ence
–An
area
whi
chpr
otru
des
orst
icks
out.
Tube
rcle
–A
bum
p.
Ana
tom
ical
voca
bula
ry
Tiss
ues
Epith
elia
l: C
onne
ctiv
e: b
lood
, bon
e, c
artil
age,
adi
pose
M
uscl
e:
Ner
vous
:
Epith
elia
l tis
sues
Epith
elia
l tis
sues
Con
nect
ive
tissu
esB
one
anat
omy
Con
nect
ive
tissu
esC
onne
ctiv
etis
sues
Mus
cle
tissu
esN
ervo
ustis
sues
Can
cer
Ang
ioge
nesi
s
Can
cer
Prot
o-on
coge
nes
Can
bec
ome
an o
ncog
ene
by 1
) poi
nt m
utat
ion,
2) G
ene
ampl
ifica
tion,
3) C
hrom
osom
al
tran
sloc
atio
n, 4
) loc
al D
NA
rear
rang
emen
ts o
r 5) I
nser
tion
mut
agen
esis
.
Extr
acel
lula
r Mat
rix
The
extr
acel
lula
rm
atrix
(EC
M)
isco
mpo
sed
ofa
varie
tyof
prot
eins
and
poly
sacc
harid
esth
atar
ese
cret
edlo
cally
and
asse
mbl
edin
toan
orga
nize
dne
twor
kin
clos
eas
soci
atio
nw
ithth
esu
rfac
eof
the
cell
that
prod
uced
them
.
Col
lage
n: fi
brou
s pr
otei
ns o
f the
mat
rix
Extr
acel
lula
r Mat
rix
Cel
l jun
ctio
ns
Adhe
sive
junc
tions
(des
mos
omes
,he
mid
esm
osom
esan
dad
here
nsju
nctio
ns)
link
adjo
inin
gce
llto
each
othe
rand
toth
eEC
M.
Alth
ough
adhe
sive
junc
tion
type
sar
esi
mila
rin
stru
ctur
ean
dfu
nctio
n,th
eyco
ntai
ndi
stin
ctin
trace
llula
rat
tach
men
tpro
tein
san
dtra
nsm
embr
ane
linke
rpro
tein
s.
Tigh
tjun
ctio
nsle
ave
nosp
ace
betw
een
plas
ma
mem
bran
esof
adja
cent
cells
topr
even
tthe
mov
emen
tof
mol
ecul
esac
ross
cell
laye
rs.
Tigh
tjun
ctio
nsbl
ock
late
ralm
ovem
ento
flip
ids
and
mem
bran
epr
otei
nsto
keep
ace
llpo
lariz
ed.
Gap
junc
tions
sepa
rate
cells
by2-
3nm
and
allo
wdi
rect
elec
trica
land
chem
ical
com
mun
icat
ion.
Gap
junc
tion
Gap
junc
tion:
a s
peci
aliz
ed in
terc
ellu
lar
conn
ectio
n th
at d
irect
ly c
onne
cts
the
cyto
plas
m o
f tw
o ce
lls, w
hich
allo
ws
vario
us
mol
ecul
es a
nd io
ns to
pas
s fre
ely
betw
een
cells
. A
nota
ble
use
of g
ap ju
nctio
ns is
in th
e el
ectri
cal s
ynap
se fo
und
in s
ome
neur
ons.
Gap
junc
tion
Cel
l Adh
esio
n M
olec
ules
(CA
Ms)
Maj
or O
rgan
Sys
tem
s (1
1)
•Circ
ulat
ory
syst
em•I
nteg
umen
tary
sys
tem
(ski
n, h
air,
nails
, etc
.)•E
ndoc
rine
syst
em•L
ymph
atic
sys
tem
•Dig
estiv
e sy
stem
•Urin
ary
syst
em•R
epro
duct
ive
syst
em•R
espi
rato
ry s
yste
m•N
ervo
us s
yste
m•S
kele
tal s
yste
m•M
uscu
lar s
yste
m
Circ
ulat
ory
syst
em
•Arte
ry•A
orta
•Vei
n•C
apilla
ry
(atr
ium
)(v
entr
icle
)(v
alve
)
Syst
olic
(con
trac
tion)
: 110
-140
Dia
stol
ic (r
elax
atio
n): 6
5 -9
0~
72 b
eats
/m
Inte
gum
enta
ry s
yste
m
Endo
crin
e sy
stem
Lym
phat
ic s
yste
m