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KenaRoots
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Chronic skin disease Other name = Leukoderma White spots occur when the skin
no longer forms melanin(pigment that determines thecolor of your skin, hair, and eyes)
The white patches of irregularshapes begin to appear on yourskin
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White patches of skin Whitening or graying of the hair on your
scalp, eyelashes, eyebrows or beard
Loss of color in the tissues that line theinside of your mouth Loss or change in color of the inner layer of
your eye
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Chalk white color Con e! margins
"mm to "cm ormore in diameter #ound, o al, or
elongated in shape AVRF
http://www.avrf.org/index.htmhttp://www.avrf.org/index.htm
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Focal pattern $the depigmentation is limitedto one or only a few areas
Segmental pattern $depigmented patchesde elop on only one side of the body
Generalized pattern $(most common)depigmentation occurs symmetrically on bothsides of the body
%ocal and segmental patterns do not spread&The generali'ed pattern is hard to predict andcan randomly stop
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Can appear at any age, usually first appears between the ages of and *
White patches may begin on your face abo e your eyes or on your neck, armpits, elbows,genitals, hands or knees
+ + of the world population de elops -ffects both genders and all races e.ually
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When no melanin isproduced, the in ol ed patchof skin becomes white
When a white patch grows orspreads the cause may be /itiligo
0!act cause is unknown 1ay be due to an immune
disorder, heredity, oren ironmental causes likesunburn or emotionaldistress that trigger thecondition
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- family history of itiligo
Look to see if there is arash, sunburn, or otherskin trauma that hasoccurred within or *months afterpigmentation wasdisco ered
2remature graying ofthe hair (before age *")
3tress or physicalillness
-lso they may ask foran eye e!amination(inflammation of youreye) and4or blood test(autoimmune disease)
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/itiligo is difficult to treat0arly treatment options include5
0!posure to intense ultra iolet light, such as narrow band6/7 therapy1edicines taken by mouth such as trimethylpsoralen(Trisoralen)
1edicines5Corticosteroid creams
8mmunosuppressants such as pimecrolimus (0lidel )and tacrolimus (2rotopic )#epigmenting agents such as metho!salen (O!soralen )
http://www.drugs.com/cdi/pimecrolimus.htmlhttp://www.drugs.com/elidel.htmlhttp://www.drugs.com/cdi/tacrolimus-ointment.htmlhttp://www.drugs.com/protopic.htmlhttp://www.drugs.com/cdi/methoxsalen-lotion.htmlhttp://www.drugs.com/cdi/oxsoralen-lotion.htmlhttp://www.drugs.com/cdi/oxsoralen-lotion.htmlhttp://www.drugs.com/cdi/methoxsalen-lotion.htmlhttp://www.drugs.com/protopic.htmlhttp://www.drugs.com/cdi/tacrolimus-ointment.htmlhttp://www.drugs.com/elidel.htmlhttp://www.drugs.com/cdi/pimecrolimus.html
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The use of steroid creams may be helpful in returning thecolor to the white patches
9octors often prescribe a mild topical corticosteroid creamfor children under + years old and a stronger one foradults
Cream must be applied to the white patches on the skin forat least * months before seeing any results
Corticosteriod creams are the simplest and safesttreatment for itiligo, but are not as effecti e as psoralen
photochemotherapy 3890 0%%0CT3 occur in areas where the skin is thin, suchas on the face and armpits, or in the genital region
› They can be minimi'ed by using weaker formulations of steroidcreams in these areas&
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Topical Calcineurin 8nhibitor s
RDNL
http://bp1.blogger.com/_PGA3lXdSci4/SBWkhQLlZ9I/AAAAAAAAAIc/MLNTgVOj4mo/s1600-h/Elidel+pimecrolimus+cream+vitiligo.jpghttp://www.rdnl.net/http://bp1.blogger.com/_PGA3lXdSci4/SBWkhQLlZ9I/AAAAAAAAAIc/MLNTgVOj4mo/s1600-h/Elidel+pimecrolimus+cream+vitiligo.jpghttp://www.rdnl.net/
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AVRF
http://www.avrf.org/index.htmhttp://www.uvbiotek.com/avrfhttp://www.avrf.org/index.htm
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1ost effecti e treatmenta ailable in the 6nited 3tates&
26/- therapy is to repigment the white patches
time consuming, and care must
be taken to a oid side effects 2soralen is a drug that containschemicals that react withultra iolet light to causedarkening of the skin&
2soralen is in:ected orally or isapplied to the skin
Then skin is carefully timede!posure to sunlight or toultra iolet - (6/-) light thatcomes from a special lamp&
WWHT Dermatology
http://www.westhertshospitals.nhs.uk/dermatology/light_treatment.asphttp://www.westhertshospitals.nhs.uk/dermatology/light_treatment.asp
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6sed for children years old and older who ha e small number white spots ina few areas
Treatments are done under an artificial 6/- light once or twice a week& 2soralen is applied to your depigmented patches about * minutes before
e!posing you to enough 6/- light to turn the affected area pink&
The doctor usually increases the dose of 6/- light slowly o er many weeks& 0 entually, the pink areas fade and a more normal skin color appears& SIDE EFFECTS:
› (+) se ere sunburn and blistering› ( ) too much repigmentation or darkening (hyperpigmentation) of the
treated patches or the normal skin surrounding the itiligo&
%or people with e!tensi e itiligo (affecting more than percent of the body)or for people who do not respond to topical 26/- therapy
;ot recommended for children under + years of age because it increases therisk of damage to the eyes caused by conditions such as cataracts&
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6sed for people with small patches of itiligo The doctor remo es sections of the normal, pigmented
skin and places them on the depigmented areas 8nfections may occur at the donor or recipient sites The recipient and donor sites may de elop scarring, a
cobblestone appearance, or a spotty pigmentation, ormay fail to cure the white spot area
Takes time and is ery costly
9octor creates blisters on your pigmented skin byusing heat, suction, or free'ing cold
The tops of the blisters are then cut out andtransplanted to a depigmented skin area
3890 0%%0CT35 scarring and lack of repigmentation Less risk of scarring with this procedure than with
other types of grafting&
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8mplanting pigment into the skin with a special surgical instrument Works best for the lip area, particularly in people with dark skin 9ifficult to match perfectly the color of the skin of the surrounding
area
The tattooed area will not change in color when e!posed to sun, whilethe surrounding normal skin will& Tattooing tends to fade o er time -lso tattooing of the lips may lead to episodes of blister outbreaks
caused by the herpes simple! irus
Takes a sample of your normal pigmented skin and places itin a laboratory dish containing a special cell culture solutionto grow melanocytes&
When the melanocytes in the culture solution ha emultiplied, the doctor transplants them to your depigmentedskin patches
Currently e!perimental and is impractical for the routine careof people with itiligo
/ery e!pensi e and its side effects are not known&
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Sunscree
n elps protect the skinfrom sunburn and longterm damage
1inimi'es tanning, which makes thecontrast between normaland depigmented skinless noticeable
7lue Li'ard 7aby>3ensiti e 3unscreen
AVRF
http://www.avrf.org/index.htmhttp://www.crownlaboratories.com/bluelizard/advertising.htmlhttp://www.avrf.org/index.htm
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Some vitiligo patients cover depigmented patches with stains, maklotions.
Dermablend, Lydia O’Leary, lini!ue, "ashion "lair, #itadye, and dyes that you may find helpful for covering up depigmented patche
Self tanning lotions have an advantage over makeup in that the coldays and will not come off with washing.
AVRF
http://www.avrf.org/index.htmhttp://www.avrf.org/index.htm
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AVRF
April
http://www.avrf.org/index.htmhttp://www.avrf.org/index.htm
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+);ational /itiligo %oundation
) /itiligo 3upport 8nternational*) -merican /itiligo #esearch %oundation 8nc&
SUPPORT
organizations
http://nvfi.org/index.phphttp://www.vitiligosupport.org/http://www.avrf.org/index.htmhttp://www.avrf.org/index.htmhttp://www.avrf.org/diversity/contributions.phphttp://www.avrf.org/index.htmhttp://www.avrf.org/index.htmhttp://www.vitiligosupport.org/http://nvfi.org/index.php
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;ation Library of 1edicine (1edicine 2lus) -merican /itiligo #esearch %oundation ;ational 8nstitutes of ealth, 9epartment of ealth an
d uman 3er ices 5 ;ational 8nstitute of -rthritis and 1usculoskeletaland 3kin 9iseases
9rugs&com (Treatments) youtube&com (Lee Thomas Turning White 4
8nter iew) ;ational /itiligo %oundation ( ideo gallery 0li'abeth
/argas 8nter iew)
http://www.avrf.org/index.htmhttp://www.niams.nih.gov/health_info/Vitiligo/default.asphttp://www.niams.nih.gov/health_info/Vitiligo/default.asphttp://www.drugs.com/enc/vitiligo.htmlhttp://www.youtube.com/watch?v=EIyQvcuTJYAhttp://nvfi.org/pages/video_gallery.phphttp://nvfi.org/pages/video_gallery.phphttp://www.youtube.com/watch?v=EIyQvcuTJYAhttp://www.drugs.com/enc/vitiligo.htmlhttp://www.niams.nih.gov/health_info/Vitiligo/default.asphttp://www.niams.nih.gov/health_info/Vitiligo/default.asphttp://www.avrf.org/index.htm
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+) ;ational /itiligo %oundation) -merican /itiligo #esearch %oundation 8nc&
*) /isuald!health?) #e olution ealth") WW T 9ermatology@)0lidelA) ;ational /itiligo %oundationB) /itiligo 3upport 8nternational
http://nvfi.org/pages/video_gallery.phphttp://www.avrf.org/index.htmhttp://www.visualdxhealth.com/adult/vitiligo.htmhttp://www.visualdxhealth.com/adult/vitiligo.htmhttp://www.avrf.org/index.htmhttp://nvfi.org/pages/video_gallery.php
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Lee Thomas
Ki s !oping "ith
Vitiligo
#liza$eth Vargas%nter&ie"
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Ingredient Main activesubstance
Action
Cocos nucifera oil
Coconut oilcontains essentialsaturated andunsaturated fattyacids, Highconcentration of
Vitamin E and K,high concentrationof Zinc and Iron.
Coconut oil is theonly ty e of oil that
one should use onone!s s"in for it isabsorbed easilyand "ee s the s"insoft# Coconut oilcontains Vitamin E
Al ha $oco herol#$his "ind ofVitamin is a %ell&"no%n otentantio'idant and isbene(cial to the
s"in.
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Ingredient Main activesubstance
Action
)soralea
corylifolia e'tract
)soralea
corylifolia contains*avons,iso*avons,furanocoumarins,chalcones andcoumesterol grou
of com ounds%hich includessoralen,
iso soralen andbavichinin+.
Psoralea corylifolia appears tohave a purely local action with a
speci c e ect on the arterioles ofthe subcapillary plexuses, whichare dilated so that the plasma isincreased in this area. he s!inbecomes red and themelanoblasts "pi#ment$formin#cells% are stimulated. &nleu!oderma, melanoblasts do notfunction properly and theirstimulation by the dru# leads
them to form and exudatepi#ments, which #radually di useinto the white leu!odermicpatches.' Also, thephytochemically induced covalentbindin# of the dru# to pyrimidinebases is responsible for itstherapeutic e ect. hephotocon(unction involves thyminedimer adducts on the oppositestrands of )*A. Psoralen has beenfound to intercalate into )*A,where they form mono$ and di$adducts in the presence of lon#wavelen#th +V li#ht and thus areused for the treatment of hypo$pi#mented lesions of the s!in,such as leu!oderma.
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Ingredient Main activesubstance
Action
erberis vulgaris
root e'tract
arberry includessuch al!aloids asberbamine, berberine,oxyacanthine, resinand tannins, andchelidonic acid.
arberry Root alsoconstituents the $vitamin thiamine,vitamin -, lutein,
eaxanthin, thecarotenoids beta$
carotene, chromium,inc, and cobalt.
arberry root hasantioxidant and
cytoprotectiveproperties.
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Ingredient Main activesubstance
Action
)icrorhi-a "urroaroot e'tract
Picrorhi a !urroa rootextract contains/ut!in, )$0annitol
and Vanillic acid
Picrorhi a !urroa wasfound to be a potentimmunostimulant ofboth cell$mediatedand humoralimmunity. picrorhi a
was reported tostimulate cellmediated andhumoral componentsof the immunesystem includin#
stimulation ofpha#ocytosis.
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Ingredient Main activesubstance
Action
MelaleucaAlternifolia.$ea$ree/ 0eaf 1il
erpineol , -ineol ,Pinene , erpinenes
)o%erful and broads ectrum antiµbial agent.Anti&bacterial,anti&fungal andanti&mycotic
agent/, and it hasan immune systemstimulant e2ect
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Ingredient Main activesubstance
Action
Emu oil 0inolinic acis and1leic acid
+sed by theAbori#inal people ofAustralia for thetreatment of muscleand (oint pain,contains a variety offatty acids. 0odernresearch into theproperties of emu oilhas found that this isthe #reatest s!inemollient in theworld, with deep s!inpenetrationproperties better than
any other natural oil.
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Ingredient Main activesubstance
Action
Vitamin E.$oco herol/
Al ha&toco herol )o%erful anti&o'idant agent
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*atural pathway for P+VA therapy. Rich source of natural powerful anti$
oxidants. Rich source of essential minerals and
vitamins for vitili#o patients.
2afe with minor side e ects. -ost e ective.
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3reat than"s for yourlistening
Kena 4oots for thera euticcosmetics
5r# Hani Mal"a%i