N E U R O B I O L O G Y OF

A G I N G

KEYWORD AND AUTHOR INDEX VOLUME 14 1993

P e r g a m o n Press New York • Oxford • Seoul • Tokyo

NEUROBIOLOGY OF AGING R E S E A R C H ON A G E - R E L A T E D P H E N O M E N A , N E U R O D E G E N E R A T I O N A N D N E U R O P A T H O L O G Y

Founding Editor: R a y m o n d T. Bartus

Editor-in-Chief PAUL D. C O L E M A N

Depar tment of Neurobiology and Anatomy The University of Rochester Medical Center

601 Elmwood Avenue, Rochester , NY 14642

RAYMOND T. BARTUS, Alkermes, Inc., 64 Sidney Street, Cambridge, MA 02130-4234

HAROLD BRODY, Department of Anatomy & Cell Biology, State University of New York, School of Medicine, Buffalo, NY 14214

IAN CREESE, Center for Molecular and Behavioral Neuroscience, 195 University Avenue, Rutgers The State University of New Jersey, Newark, NJ 07102

CALEB FINCH, An&us Gerontology Center, University of Southern California, University Park, Los Angeles, CA 90089

EUGENE M. JOHNSON, JR., Department of Pharmacology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110

Editors

KENNETH S. KOSIK, Harvard Medical School, Brigham & Womens' Hospital Center for Neurologic Diseases, 75 Francis St., Boston, MA 02115

GAIL R. MARSH, Medical Psychology and Director of Research, Center for Study of Aging, Duke University Medical Center, Box 2908, Durham, NC 27710

JAMES I. MORGAN, Department of Neuroscience, Roche Institute for Molecular Biology, 340 Kingsland Ave., Nutley, NJ 07110

DONALD L. PRICE, Department of Pathology, The Johns Hopkins University School of Medicine, 558 Ross Research Bldg., 720 Rutland Ave., Baltimore, MD 21205-2196

Structure---H. Brady Dorothy G. Flood (Rochester, NY) Bradley T. Hyman (Boston, MA) Jeffrey H. Kordower (Chicago, IL) Marek-Marsel Mesulana (Boston, MA) John H. Morrison (New York, NY) Elliot Mufson (Chicago, IL) Roberta J. Pentney (Buffalo, NY) Dick F. Swaab (Amsterdam, Nethert.) Mark West (Aarhus, Denmark)

Pharmacology & Aninud Models---R. Bartus Sergio Algeri (Milan, Italy) Joseph T. Coyle (Belmont, MA) Ezio Giacobini (Springfield, IL) Domdd J. Jenden (Los Angeles, CA) James A. Joseph (Baltimore, MD) Giancarlo Pepeu (Florence, Italy) Elaine K. Perry (Newcastle, England) George S. Roth (Baltimore, MD) Joseph Springer (Philadelphia, PA) Jared R. Tinklenberg (Stanford, CA) Leon Thai (San Diego, CA)

Gene Expression & Neurogenetics--J. Morgan Konrad Beyreuther (Heidelberg, Germany) Peter Davies (Bronx, NY) James Eberwine (Philadelphia, PA) D. Carleton Gajdusek (Bethesda, MD) Karl Herrup (Cleveland, OH) George M. Martin (Seattle, WA) Colin Masters (Perth, W Australia) Alien D. Roses (Durham, NC)

Editorial Advisory Board

Alzheimer's Disease & Other Dementias--K. Kosik, D. Price John P. Blass (White Plains. NY) David A. Drachman (Worcester, MA) John H. Growdon (Boston, MA) Y. Ihara (Tokyo, Japan) Lissy F. Jarvik (Los Angeles, CAI Robert Katzman (La Jolla, CA) Zaven S. Khachaturian (Bethesda, MD) David M. A. Mann (Manchester, U.K.) William R. Markesbery (lexington, KY) Creighton H. Phelps (Bethesda, MD) M. N. Rossor (London, England) Dennis J. Selkoe (Boston, MA) Jared R. Tinldenberg (Stanford, CA) Bengt Winblad (Huddinge, Sweden) Henry M. Wisniewski (Staten Island, NY) Steven Younkin (Cleveland, OH)

Neurochemistry & Transmitter Systems--I. Creese Michel Baudry (Los Angeles, CA) David M. Bowen (London, England) Carl W. Cotman (h'vine, CA) Edythe D. London (Baltimore, MD) Edith G. McGeer (Vancouver, Canada) Daniel Marshak (Cold Spring Harbor, NY) Jay W. Pettegrew (Pittsburgh, PA) Stanley I. Rapoport (Bethesda, MD) Paul R. Sanberg (Tampa, FL) J. Randall Slemmon (Rochester, NY) Stanley J. Watson (Ann Arbor, MI) Bengt Winblad (Huddinge, Sweden)

Cell Biology & Trophic Factm-s--E. Jolmson Stanley H. Appel (Houston, TX) Fred H. Gage (San Diego, CA) Pierluigi Gambetti (Cleveland, OH) Gary E. Gibson (White Plains, NY) Franz F. Hefti (San Francisco, CA) Daniel P. Perl (New York, NY) Joseph Rogers (Sun City, AZ) Dennis J. Selkoe (Boston, MA) Michael L. Shelanski (New York, NY)

Behavior--G. Marsh Marilyn S. Albert (Boston, MA) Suzanne H. Corkin (Cambridge, MA) Robert Davis (Ann Arbor, MI) Steven H. Ferris (New York, NY) Donald K. Ingrain (Baltimore, MD) Richard C. Mohs (Bronx, NY) David S. Otton (Baltimore, MD) Susan S. Schiffman (Durham, NC) David W. Shucard (Buffalo, NY) Steven F. Zornetzer (Arlington, VA)

Physiology--C. Finch Carol Barnes (Tucson, AZ) Robert E+ Dustman (Salt Lake City, UT) Philip W. Landfield (lexington, KY) Bruce S. McEwen (New York, NY) Bruce L. McNaughton (Tucson, AZ) James F. Nelson (San Antonio, TX) Robert M. Sapolsky (Stanford, CA) Celia Sladek (N. Chicago, IL) Dean O. Smith (Madison, WI) William Sonntag (Winston-Salem, NC)

NEUROBIOLOGY OF AGING

Editorial Offices." Paul D. Coleman

Department of Neurobiology and Anatomy, The University of Rochester Medical Center 601 Elmwood Avenue, Rochester, NY 14642

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Pergamon Press, Tarrytown, NY

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Neurobiology of Aging, Vol. 14, III-IV, 1993 Printed in the U.S.A. AU fights reserved.

0197-4580/93 $6.00 + .00 Copyright © 1993 Pergamon Press Ltd.

AI3 peptide, 571 A~, 589 Acetyl-l-carnitine, 107 Acetylcholine, 65,479 Acetylcholinesterase, 393 Achromatopsia, 471 ACTH, 101 Activity, 565 Adaptation, 359 Adenylate cyclase, 65 Adrenocorticotropic hormone, 101 Aequorin, 447 Afterhyperpolarization, 17 Age, 267 Age-effect, 107 Aged rats, 359, 457,487 Aging rats, 509 Aging, 17, 57, 97, 101, 197, 217,

223,239,245, 249, 259, 287,309, 319, 337,359, 383,389, 393,401, 431,447,499, 503, 519, 523,561, 565, 575,597

Aging:EEG and evoked potentials, 73 Aging:gender difference, 73 Aging:healthy adults, 73 Alcoholism, 421 Alpha-2 adrenoceptors, 597 a2-macroglobulin, 233 Alz-50, 589 Alzheimer's disease, 1, 35, 85, 207,

223,233,267, 303,343,353, 367, 407, 447, 471,523,539, 547, 589

AMPA, 197 Amyloid precursor protein, 571 Amyloid, 207 Angiotensin II, 519 Animal model, 547 Anion transport, 223 Area 17, 343 Area 18, 343 Area 21,343 Aspartate transaminase, 393 Atropine, 487 Autoimmunity, 223 Autopsy, 589 Autoradiography, 197

B-50/GAP-43, 401 Baclofen, 17 BALB/c mouse, 239 BALB/c, 197 Band 3,223 Basal forebrain lesion, 487 Basal forebrain, 457 Bed nucleus of stria terminalis, 499 Bed nucleus of the stria terminalis

medialis, 245 Behavior, 431 Benzodiazepine, 343

KEYWORD INDEX

13-amyloid, 547 13-endorphin, 529 Biological rhythms, 101 Biopsy, 589 Body temperature, 565 Bradykinin, 447 Brain aging, 373, 421 Brain samples, 539 Brain slice, 499 Brain stem, 529 Brain, 35

C57B 1/6, 197 c-fos, 441 CA1, 17, 27 CA1 extracellular potentials, 249 Ca 2 + efflux, 373 Ca 2+ permeability, 373 Ca 2+, 373 CA3, 27 Calcium homeostasis, 479 Calcium, 447 Calcium-dependent event, 17 Canine, 547 Carbachol, 17 Catecholamines, 383,431 Cell number, 245 Centrophenoxine, 319 Cerebellum, 547 Cerebrospinal fluid, 267 Cholecystokinin, 529 Choline acetyltransferase, 367, 389,

457 Cholinergic hypothesis, 93 Cholinergic, 535 Cholinesterase inhibitors, 93, 393 Chromogranin, 267 Chromosome 21,407 Circadian rhythms, 101,441 Circadian rhythms, 565 CNS selectivity, 93 Cognition, 35 Cold stress, 217 Color, 471 Complex spike cell, 259 Computerized morphometric image

analysis, 303 Cortex, 65, 197,529 Cortical connectivity, 1 Corticosterone, 239, 421 Corticotropin-releasing hormone, 97 Cortisol, 101 CRH challenge, 97 Cytokines, 421

DAU 6215, 561 Decortication, 295 Delayed response task, 597 Dementia, 1,233,267, 407,471,589

111

Dendrites, 575 Diagnosis, 539 Disector, 275, 287 Diurnal rhythm, 529 Dopamine, 431 Down's syndrome, 223

Early response genes, 441 Electrical stimulation, 499 Endogenous inhibitor, 367 Epinephrine, 359 Erythrocyte, 223 Ethanol, 229 Eveningness, 101 Excitotoxicity, 295 Exercise, 331 Extrastriate cortex, 35

F344 rats, 421 Face perception, 35 Fascia dentata, 27 Fibroblasts, 447 Fischer 344, 575 Fischer 344 rat, 259 5-HT3 receptor, 561 Fluid ingestion, 519 Forskolin, 65 Fractionator, 275 Frontal cortex, 589 Fura-2, 447

Gender, 421 Gene expression, 503 GFAP, 421 Glucose, 523 Gluococorticoid receptors, 97 Glutamate, 197 Glycine, 343 Golgi, 575 Growth-releasing hormone, 503 GTP, 65

Hippocampal neurons, 17, 207 Hippocampus, 97, 197, 239, 249,

259, 287, 309, 319, 401,509, 529 Human genetics, 407 Human, 337 Hypothalamus, 337, 529, 575

IgG, 223 Immediate early genes, 441 Immunocytochemistry, 233,245 Inbred strains, 97 Individual differences, 57

Kainate, 197

Learning, 259 I.~u-enkeph~in, 529

IV INDEX

Lewy bodies, 407 Lewy body disease, 233 Lifespan, 431 Lipid peroxidation, 319 Lipofuscin concentration, 3 ! 9 Lizard brain, 217 Locus coeruleus, 245 LTE, 107 Luteinizing hormone, 337

Medial amygdala, 245 Medial septum, 389 Melatonin, 565 Membrane fluidity, 229 Membrane, 223 Memory, 259, 287,393, 523 Menopause, 337 Met-enkephalin, 529 Methanesulfonyl fluoride, 393 Mice, 309 Microvessels, 229 Mini-Mental State Examination, 589 Mitochondria, 479 Mitochondrial calcium uniporter, 479 MK-801,295 Morningness, 101 Morphology, 457 Morphometry, 275 Morris spatial task, 309 Morris water maze, 561 Mouse, 97, 197 MPP ÷ , 295 mRNA, 421 MSF, 93 Multiple-unit activity, 319 Muscarinic, 509 Muscle fiber atrophy, 331

Nerve growth factor receptor, 457 Neurite outgrowth, 207 Neuritic dystrophy, 547 Neuritic plaques, 1,589 Neuroanatomy, 431 Neuroendocrine, 421 Neurofibrillary tangles, 1,589 Neuron counting, 275 Neuron loss, 287 Neuronal counts, 547 Neuronal hypertrophy, 337 Neuronal number, 575 Neuropathology, 233,407,421,539,

547 Neurophysiology, 239 Neuropil threads, 303

Neuropsychologic tests, 589 Neuropsychology, 407 NGFI-A, 441 NGFI-B, 441 NMDA receptors, 107 NMDA, 197, 343 Nonlinear regression, 259 Noradrenaline, 499 Norepinephrine, 359, 597 Nucleoli, 575 Nucleus basalis magnocellularis, 535 Nucleus basalis, 389

Occipital lobe, 343 Olfactory system, 353 One-trial learning, 393 Oxidative enzyme activity, 331

Parkinson's disease, 431 Pathogenesis, 353 Phosphatidylserine, 401 Phospho-L-serine, 367 Phosphodiesters, 85 Phosphomonoesters, 85 Phosphopmtein dephosphorylation, 479 Phosphorus magnetic resonance

spectroscopy, 85 Phosphorylation, 401 Physostigmine, 487 Pick's disease, 85 Pineal gland, 565 Pituitary, 529 Place learning-set spatial task, 309 Plaque formation, 547 Plasma membrane vesicles, 373 Plasma, 359 Positron emission tomography, 35 Postmortem human brain, 421 Potentiation mechanisms, 249 Prefrontal cortex, 597 Primates, 597 Protein kinase C (PKC), 309

Quisqualate, 197

Rat brain, 373 Rat(s), 17, 27, 57,295,331, 383,

389, 575 Reaction time, 57 Reward learning, 393 Rhythmicity, 101

Scopolamine, 93 SDAT, 93

Secretogranin, 267 Senile plaques, 207 Sensorimotor deficits, 57 Serum stimulation, 447 Single units, 27 SKF104078, 597 SKF104856, 597 Sleep, 565 Slice, 17,239 Soleus muscle, 331 Somatostatin, 503,529 Spatial learning, 57, 107,561 Spatial memory, 249, 487 Spinal motoneuron, 331 Starvation, 217 Stereology, 275,287,295, 337 Steroid feedback, 337 Strain comparison, 17 Stress, 359 Striatum, 65,529 Subcoeruleus, 245 Substance P, 529 Substantia nigra, 295, 431 Substrate, 403 Suprachiasmatic nucleus, 565 Supraoptic nucleus, 575 Sympathetic neurons, 383 Synaptic transmission, 509 Synaptosomes, 479

T maze, 535 Tau immunocytochemistry, 303 Taurine, 359 Temporal lobe, 343 Testosterone, 337,421 Thalamus, 535 Tibialis anterior muscle, 331 Tissue culture, 207 Translation initiation, 571 Transplantation, 383 Transport, 373 Tritanomalous, 471 Trophic factor, 547 Tyrosine hydroxylase, 383

Vasopressin, 245 VIP, 441 Vision, 47l Visual cortex, 343 Voltammetry, 499

Water maze, 487 Working memory, 479

Neurobiology of Aging, Vol. 14, V-VI, 1993 Printed in the U,S.A. All rights reserved.

0197-4580/93 $6.00 + .00 Copyright © 1993 Pergamon Press Ltd.

Abraham, C. R,, 677 Albert, M. S., 73 Albert, M., 623 Amaral, D. G., 671 Andriamampandry, C., 367 Aparicio, J. J., 479 Armstrong, D. M., 457 Arnsten, A. F. T., 597,639

B a c h e v a l i e r , J . , 619 Barnes, C. A., 27, 107,645 Bartholomeus, I. G. P., 223 Bartus, R. T., 711 Beal, M. F., 295,707 Bennett, D. A., 589 Bertholet, J.-Y., 97 Bickford, P., 259 Blanco, P., 479 Blazer, D. G., 101 Bog6nez, E., 479 Booze, R. M., 389 Borsini, F., 561 Bos, N. P. A., 565 Bosman, G. J. C. G. M., 223 Bradley, J., 249 Brambilla, A., 561 Breckler, S. J., 695 Brooks, J. W., 353 Brouillet, E., 295 Burwell, R. D., 57 Buzsaki, G., 457

Cai, J. X., 597 Carlier, E., 239 Carlson, M. D., 343 Carpenter, M. K., 207 Carson, R. E., 35 Chachich, M. E., 431 Chen, K. S., 457 Citron, M., 571 Clark, C., 407 Cocchi, D., 503 Cochran, E. J., 589 Coleman, P. D., 539, 575 Colvin, R. A., 373 Connor, D. J., 535 Cork, L. C., 613,675 Corkin, S., 471,703 Cotman, C. W., 197, 547 Crain, B., 407 Crawford, F., 407 Cronin-Golomb, A., 471 Crothers, M. K., 393 Crutcher, K. A., 207 Cummings, B. J., 547 Cutler, R. G., 687

Davies, A. J. S., 605 Davies, D. C., 353

AUTHOR INDEX

Davis, N., 373 Davis, S., 107 Day, J. R., 421 De Gennaro Colonna, V., 503 De Graan, P. N. E., 401 De Grip, W. J., 223 De La Garza, R., 259 De Lacoste, M.-C., 1, 55 De Man, A. J. M., 223 De Strooper, B., 233 Deadwyler, S. A., 389 Delagrange, P., 565 Dement, W. C., 441 Deupree, D. L., 249 Dokas, L. A., 65 Dom, R., 233 Doumaud, P., 97 Duffy, F. H., 73 Dutar, P., 17

Engstrom, D. A., 259

Ferebee, R. N., 393 Fidone, F., 503 Finch, C. E., 421 Flood, D. G., 575,649 Fordyce, D. E., 309

Gage, F. H., 457,487 Gallagher, M., 57,631 Gallenstein, L. G., 85 Gaskell, P., 407 Gianotti, C., 401 Gillette, J., 35 Gilley, D. W., 589 Globerson, A., 605 Goate, A., 407 Gold, P. E., 523 G6mez-Puertas, P., 479 Gonzalez-Aviles, A., 35 Gorman, L. K., 699 Grady, C. L., 35 Griffith, W. H., 509 Growdon, J. H., 471 Guardiola-Lemaitre, B., 565 Gupta, M., 431

Haas, C., 571 Hamill, R. W., 539 Hardy, J., 407 Harris, N., 359 Haxby, J. V., 35 Heller, H. C., 441 Hengemihle, J., 431 Herscovitch, P., 35 Hersh, L. B., 457 Hervonen, A., 383 Horwitz, B., 35

V

Huidobro, A., 479 Hyman, B. T., 45,295

Ingram, D. K., 431,687 Ishihara, A., 331 Ishimaru-Tseng, T. V., 519

Johnson, S. A., 421 Jorm, C. M., 499 Joseph, J. A., 605

Kailasam, M. T., 267 Kaneko, K., 407 Kanfer, J. N., 367 Kater, S. B., 207 Katsuya, T., 407 Kemper, T. L., 659 Kilduff, T. S., 441 Koistinaho, J., 383 Kojima, T., 407 Kos, W. T., 245 Kosik, K. S., 303 Koster-Van Hoffen, G. C., 565 Kowall, N. W., 303 Kryscio, R. J., 85

Lake, J. R., 393 Lamour, Y., 17 Lane, M. A., 687 Langdon, D. J., 535 Langlais, P. J., 535 Lantos, P., 407 Laping, N. J., 421 Layton, W. J., 85 Leverenz, J. B., 589 Lewis, D. A., 353 Long, J. M., 431 Luthert, P., 407

Magnusson, K. R., 197 Malin, D. H., 393 Malmrose, L. C., 101 Man, S. Y., 529 Manning, C. A., 523 Markesbery, W. R., 85,303, 539 Markowska, A. L., 107 Martin, L. J., 681 Martinez-Serrano, A., 479 Maurya, A. K., 319 McAnulty, G. B., 73 McCoy, K. R., 447 McDaniel, K., 539 Mckee, A. C., 303 McMullen, N. T., 337 McNaughton, B. L., 27 Meckelein, B., 677 Miki, T., 407 Milakofsky, L., 359 Mirmiran, M., 565

VI INDEX

Mishkin, M., 615 Mishra, P. N., 217 Miyatake, 407 Mooradian, A. D., 229 Morley, J. E., 519 Morley, P. M. K., 519 Morrison, J. H., 51 Moss, D. E., 93,393 Moss, M. B., 635 Mullan, M., 407 Miiller, E. E., 503 Mullins, R. D., 447 Murphy, C. A., 373

Nakano, I., 407 Naruse, S., 407 Nearing, B., 457 Nee, L. E., 447 Negrete, P. G., 393 Nemeroff, C. B., 101 Newcomb, T. G., 447 Ng, G. M., 447 Nichols, N. R., 421 Nilsson, O. G., 487 Nunzi, M. G., 401

O'Connor, D. T., 267 Oestreicher, A. B., 401 Ogihara, T., 407 Olton, D. S., 637 Ovenstone, I., 407

Pacheco, G., 93 Palacios-Esquivel, R. L., 93 Pamaik, B. K., 217 Pavlfnkov~i, G., 447 Penney, Jr., J. B., 343 Pereira, R., 479 Peters, A., 657 Pitsikas, N., 561 Plotner, R. E., 393 Polinsky, R. J., 447 Porta, A., 401 Potier, B., 17 Price, D. L., 685 Price, J. L., 661

Quirion, R., 691

Radulescu, S. J., 393 Ragozzino, M. E., 523 Rance, N. E., 337 Rao, G., 27 Rapoport, S, I., 35 Rapp, P., 627 Ravid, R., 245 Razzaboni, B. L., 677 Rebeck, G. W., 45 Reed, D. A., 101 Ritchie, J. C., 101 Roberts, G., 407 Roques, P., 407 Rose, G. M., 259 Rosene, D. L., 669 Roses, A., 407 Roth, G. S., 687 Russell, M. J., 547

Salerno, J. A., 35 Saper, C. B., 49 Saper, C. B., 589, 705 Sarrieau, A., 97 Satrdstegui, J., 479 Schaefer, P. J., 393 Schapiro, M. B., 35 Selkoe, D. J., 57t Sharma, D., 319 Sheffield, R., 457 Shimizu, T., 407 Silver, A. J., 519 Singh, R., 319 Sisken, J. E., 447 Smith, C. D., 85 Smith, M. L., 389 Smith, T. L., 229 Soumireu-Mourat, B., 239 Srivastava, R., 295 Stamford, J. A., 499 Storey, E., 295 Su, J. H., 547 Sugiura, R., 471 Suhonen, J., 383 Sutin, E. L., 441

Swaab, D. F., 245

Taguchi, S., 331 Talmi, M., 239 Tang, F., 529 Taylor, L., 509 Thal, L. J., 267,535 Tigges, J., 655 Ting, S.-M., 65 Triau, E., 233 Tsuji, S., 407 Turner, D. A., 249 Tyrey, M. E., 101

Uno, H., 673 Uswandi, S. V., 337

Van Gool, D., 233 Van Leuven, F., 233 Van Zwieten, E. J., 245 Villa, A., 479 Villalba, M., 479 Visser, F. E., 223 Vogel, W. H., 359 Voytko, M. L., 643

Wagster, M. V., 693 Walker, L. C., 667 Wallsten, S. M., 101 Wang, H. Z., 303 Wang, Z. P., 529 Wehner, J. M., 309 Wenk, G. L., 107,689 West, M. J., 275, 287 White, Iii, C. L., 1, 55 White, R., 547 Wiener, H. L., 431 Wilson, R. S., 589 Wisniewski, H. M., 665 Witting, W., 565 Wu, A., 373

Young, A. B., 343 Young, D., 259

Zola-Morgan, S., 647