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    Journal of Knowledge ManagementEmerald Article: Knowledge-sharing enablers and barriers in pharmaceuticalresearch and development

    Anne-Mette Lilleoere, Ebba Holme Hansen

    Article information:

    To cite this document: Anne-Mette Lilleoere, Ebba Holme Hansen, (2011),"Knowledge-sharing enablers and barriers in pharmaceutical

    esearch and development", Journal of Knowledge Management, Vol. 15 Iss: 1 pp. 53 - 70

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    Knowledge-sharing enablers and barriers

    in pharmaceutical research and

    development

    Anne-Mette Lilleoere and Ebba Holme Hansen

    Abstract

    Purpose Because selling innovative products is crucial to its livelihood, the pharmaceutical industry

    has a fundamental need to share knowledge to stimulate the process of knowledge creation. This study

    seeks to explore knowledge-sharing enablers and barriers in pharmaceutical R&D.

    Design/methodology/approach A case study was carried out in a pharmaceutical company in

    Denmark. R&D professionals were asked to identify organizational enablers and barriers to knowledge

    sharing. Their accounts were processed as text during workshops. Data were condensed thematically.

    The analysis was combined with the conceptualization of tacit and explicit knowledge as proposed by

    Nonaka and Takeuchi.

    Findings The research shows that R&D professionals have different views and practices regarding

    engaging in knowledge sharing. This reveals that knowledge sharing is multi-faceted and that one

    standard for R&D professionals does not exist. The enablers identified recognized the use of tacit

    knowledge. The existence of enablers and barriers with oppositional influence on knowledge-sharing

    practices is evident. Furthermore, synergy is identified in the knowledge-sharing enablers provided that

    the settings fostering personal closeness to colleagues are stimulated. Physical proximity to colleagues

    therefore has obvious influence on knowledge-sharing practices.

    Research limitations/implications This study was basedon a single case study. The extent to which

    the findings can be generalized to other industries is unknown.

    Practical implications The findings have implicationsfor R&D managers who must be aware of these

    professional diversities in order to enhance knowledge-sharing practices.Attention should also be given

    to the synergies hidden in knowledge-sharing enablers.Originality/value Focused implementationof enablers will increase knowledge-sharing practices and

    minimize barriers.

    Keywords Knowledge management, Pharmaceuticals industry, Research and development,Case studies, Quality, Research

    Paper type Case study

    1. Introduction

    The pharmaceutical industry has been known for its creation of innovative products

    (Horrobin, 2001). However, the industrys innovative pipeline has dried out over the last

    decade. The pharmaceutical industry has unique characteristics such as a highly regulatory

    environment, long development cycles, and a high level of risks and costs in the R&D

    process. Time from discovery to marketing of a new drug requires on average 8-10 years(Ganguli, 2003). A main focus in the pharmaceutical industry is therefore to reduce

    time-to-market. In order to stay competitive, companies have focused on other initiatives

    such as maximizing the potential of existing product portfolios and practicing incremental

    innovation (Tranter, 2000) with focus on life cycle management and technical solutions

    particularly reducing time-to-market. This focus has meant that other aspects of this

    innovative shortage have been overlooked or at least not fully discussed taken into account.

    One of these aspects is the potential of individuals and their actions and interactions within

    the R&D organization. The pharmaceutical industry has unique characteristics such as a

    DOI 10.1108/13673271111108693 VOL. 15 NO. 1 2011, pp. 53-70, Q Emerald Group Publishing Limited, ISSN 1367-3270 j JOURNAL OF KNOWLEDGE MANAGEMENT j PAGE 53

    Anne-Mette Lilleoere is

    based at Novo Nordisk A/S

    Research & Development,

    Gentofte, Denmark.

    Ebba Holme Hansen is

    based in the Faculty of

    Pharmaceutical Sciences,

    Section for Social

    Pharmacy at the University

    of Copenhagen,

    Copenhagen, Denmark.

    The authors would like to thankthe employees at Novo Nordisk

    R&D, Denmark for participatingin this study, as well as NovoNordisk R&D for funding thisPhD project. The authors aregrateful forthe support of EjvindJensen, Director, Novo NordiskR&D, during the initiation of thisPhD project and throughout theprocess.

    Received: 16 March 2010Accepted: 12 July 2010

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    highly regulatory environment, long development cycles, and a high level of risks and costs

    in the R&D process. Time from discovery to marketing of a new drug requires on average

    8-10 years (Ganguli, 2003).

    One area where organizations may be able to increase their innovative performance is

    knowledge sharing created through interactions among individuals. The value of knowledge

    sharing is also related to the fact that organizational knowledge is a unique asset difficult to

    imitate (Gupta and Govindarajan, 2000; Sapienza and Lombardino, 2006). Knowledge

    sharing is therefore believed to enhance the creation of knowledge, potentially enabling new

    innovative products to be developed at greater speed. However, knowledge sharing does

    not come about easily. Knowledge sharing is strongly dependent on the setting, various

    personal beliefs, and the actions and practices among the individuals involved. In this

    perspective, the understanding and acknowledgement of individual diversities in

    knowledge sharing is fundamental to catalyzing the process within R&D organizations.

    Therefore uncovering the knowledge-sharing enablers and barriers of different professional

    groups and learning how they apply to pharmaceutical R&D is important to innovative

    performance.

    2. Aim

    This article explores the knowledge-sharing enablers and barriers in pharmaceutical R&D as

    experienced by different professional groups, i.e. scientists and laboratory technicians. The

    research is based on a qualitative, single case study (Yin, 2003) conducted at Novo Nordisk

    R&D, Denmark.

    The focus of the empirical analysis is on the project level, because this level provides the

    primary context for the performance of knowledge creation modes in the organization. In

    addition, the lack of prior empirical research into the diversity of knowledge-sharing enablers

    and barriers of different professionals groups in R&D makes findings relevant to R&D

    managers in the pharmaceutical industry. Therefore this research contributes to the present

    knowledge gap. The findings are suggested to be highly relevant as knowledge sharing in

    organizations can contribute reducing time-to-market in pharmaceutical R&D hereby

    creating competitive advantage.

    3. Knowledge sharing

    Knowledge sharing can be conceptualized in various ways ranging from the exploration of

    new knowledge through renewed combinations of existing knowledge to the exploitation of

    existing knowledge (Szulanski, 1996; Uzzi and Lancaster, 2003). Knowledge sharing can

    also be seen as a process of knowledge exchange. It has been argued that the motivation

    for these different exchanges is related to the expectation of receiving something in return

    (Fiske, 1991). Grant (1996) also argues that knowledge sharing is about ensuring that

    existing knowledge is distributed within or across organizational boundaries.

    A key task for R&D organizations is to ensure that knowledge is captured and shared for the

    continuous knowledge creation processes (Berends et al., 2006). Different approaches

    dealing with knowledge sharing exist such as the SECI model (Nonaka and Takeuchi, 1995).

    The SECI model deals with two knowledge dimensions; tacit knowledge and explicit

    knowledge, respectively. Knowledge that can be shared easily is referred to as explicit

    knowledge, while knowledge that is difficult to share is referred to as tacit knowledge

    (Nonaka and Takeuchi, 1995). Tacit knowledge is thus inherently difficult to share acrossorganizational units such as departments, functions and groups due to its stickiness. Tacit

    knowledge is hard to communicate because it is socially embedded and based on personal

    experiences (Von Hippel, 1994; Nonaka, 1994; Szulanski, 1996; Osterloch and Frey, 2000).

    Knowledge sharing can positively influence organizational performance through sharing

    both tacit and explicit knowledge, which emerges into a knowledge creation spiral as

    proposed by Nonaka and co-worker (Nonaka and Takeuchi, 1995). According to these

    authors, knowledge is dynamically created through the interaction between individuals,

    ultimately through the interaction between tacit and explicit knowledge. This

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    conceptualization is often referred to as SECI, an acronym specifying four knowledge

    creation modes: socialization, externalization, combination, and internalization (Nonaka and

    Takeuchi, 1995).

    The elements in the SECI model address core aspects of knowledge. However, the model

    has not previously been applied in published, empirical studies conducted in

    pharmaceutical R&D. Different aspects of knowledge is also essential in pharmaceutical

    R&D, and hence the SECI model has been a central element for the analysis of this present

    study.

    Chou discussed the link between knowledge sharing and knowledge creation (Chou, 2005).He argues that three kinds of issues may have an impact on knowledge creation: the

    individuals ability to absorb and share knowledge, organizational learning mechanisms,

    and the ability to store and retrieve knowledge. Absorptive capability refers to the

    individuals ability to utilize available knowledge (Griffith et al., 2003; Cohen and Levinthal,

    1990).

    Published empirical studies dealing with the exploration of knowledge-sharing enablers and

    barriers in pharmaceutical R&D are scare. The enablers of organizational creativity in

    pharmaceutical R&D were explored earlier in an empirical study by Sundgren et al. (2005).

    This study suggested that information sharing and intrinsic motivation were important

    enablers for organizational creativity. Another empirical study explored the role of

    knowledge sharing measured as the number of patents in pharmaceutical R&D (Cardinal

    and Hatfield, 2000). This study showed that industries with more than one R&D laboratory

    created more patents than others. Furthermore, R&D laboratories close to headquarters, i.e.

    within 100 miles, did not stimulate patent activity but did enhance new drug productivity.

    These findings provided evidence that corporate interference in firms was harmful to basic

    research as represented by patents.

    In another empirical study, Styhre et al. (2008) demonstrated the positive impact of utilizing a

    knowledge-sharing facilitator in meetings between clinical research teams in

    pharmaceutical R&D. By paying careful attention to participants, the facilitator was able to

    help them create a joint sense of confidence and purpose. Brachos et al. (2007) also studied

    different factors relevant for transferring knowledge between units (in the pharmaceutical

    industry among others). Brachos and co-workers found that contextual factors such as trust,

    motivation, management support and learning were crucial for fostering knowledge transfer.

    In addition, an empirical study conducted by Schulze and Hoegl (2006) showed the

    importance of the socialization mode to the concept phase of new product development inseveral industries, including mechanical equipment, electrical products, medical devices,

    automotive, and information technologies. Empirical studies conducted in the

    pharmaceutical industry have found that sharing of tacit knowledge is important for

    knowledge creation (Cardinal and Hatfield, 2000; Kneller, 2003; Nerkar, 2003; Thompson

    and Heron, 2006; Chang et al., 2007).

    3.1 Knowledge-sharing enablers

    The creation of a knowledge-sharing culture is thought to be one of the most important

    knowledge-sharing enablers (Davenport and Prusak, 1998). Thus, one key challenge may

    be to facilitate effective knowledge sharing in the organization by ensuring adsorptive

    capacity and a culture that supports knowledge sharing (Nielsen, 2006). In an R&D

    environment, Dewett (2007) demonstrated empirically that employee creativity is related to

    self-efficacy and interest in ones work. Incentives can also facilitate an individualswillingness to participate in knowledge sharing (Cabrera and Cabrera, 2002; Chang et al.,

    2007).

    Knowledge sharing has a strong social dimension in which knowledge work may best be

    practiced in informal settings that assimilate social exchanges (Alvesson, 2004). Corti and

    Lo Storto (2000) highlight that common coffee and lunch breaks are settings that enable

    knowledge sharing due to the fostering of personal closeness. Physical proximity was

    stimulated through job-rotations in pharmaceutical marketing enabling knowledge sharing

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    and hence knowledge creation (Leenders and Wierenga, 2002). In an empirical study,

    Cardinal and Hatfield (2000) found that human networks were one of the key vehicles for

    sharing knowledge and that trust among individuals was related to informal networks. Tsai

    and Ghoshal (1998) emphasized the role of social ties as channels for knowledge sharing.

    Social ties have also been found valuable; empirical findings by Levin and Cross (2004)

    demonstrated that individuals are five times more likely to contact other individuals than to

    use technical systems.

    Von Krogh et al. (2000) proposed relationships exhibiting a high degree of care for the other,

    i.e. mutual trust, active empathy, access to help, leniency in judgment, and courage asenablers of knowledge sharing. In another study, Styhre et al. (2002) suggested that care

    was the underlying key factor behind knowledge-creation in team-based organizations

    involving tacit knowledge. An employee feels motivated to share knowledge once he or she

    has a good relationship with another person (Deci and Flaste, 1995), or social relations have

    proven to be helpful (Von Krogh et al., 2000). In addition, an empirical study suggests that

    social dilemmas are also embedded in knowledge-sharing practices, because

    organizational knowledge is more likely to be shared with a person who is highly likeable

    rather than with someone who is highly competent (Casciaro and Lobo, 2005). Furthermore,

    common identity often facilitates knowledge sharing as individuals within one group

    understand each other better than people from outside the group, i.e. people are embedded

    in the same practice, speak the same technical language and have a similar identity (Adler

    and Kwon, 2002; Borgatti and Cross, 2003; (Currie and Kerrin, 2003).

    3.2 Barriers to knowledge sharing

    The opposite of a knowledge-sharing enabler often also exists as a barrier. Some of these

    barriers are: no knowledge of where knowledge is available, no knowledge about the

    existence of valuable knowledge (ODell and Grayson, 1998; Gupta and Govindarajan,

    2000), not having access to knowledge (Hansen et al., 1999), the epistemological

    differences between tacit and explicit knowledge (Nonaka and Takeuchi, 1995; Szulanski,

    2003), the assumption that knowledge equals power (Bartol and Srivastava, 2002), and

    large physical and social distance between individuals (McLaughlin et al., 2008). Cabrera

    and Cabrera (2002) had described how a certain belief, such as not having valuable

    information that was relevant to others, was an obstacle to engaging in knowledge-sharing

    practices.

    Szulanski (1996) found that knowledge sharing is inhibited by three major factors:

    1. lack of absorptive capacity of the recipient;

    2. casual ambiguity concerning the knowledge itself; and

    3. an arduous relationship between the sender and the receiver (the latter point has also

    been made by Albrams et al. (2003)).

    Szulanski also found that motivational factors played only a minor role in connection with

    transferability of knowledge. These findings indicate that successful knowledge sharing

    requires more than just transferring knowledge. In addition, knowing that knowledge exists is

    not enough to initiate knowledge sharing, as it presupposes a relationship among those

    involved (Szulanski, 1996). Napier and Ferris (1993) describe how physical distance

    between colleagues makes it more difficult for them to share dimensions of tacit knowledge.Tacit knowledge is socially embedded and increasing its potential would require settings

    that simulate physical proximity (Cardinal and Hatfield, 2000).

    This present study will uncover knowledge-sharing enablers and barriers among different

    professional groups working in pharmaceutical R&D. Insights into knowledge-sharing

    enablers and barriers is a foundation for the application of a successful knowledge

    management approach in an organization (Birkenshaw, 2001).

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    4. Methods and data

    4.1 Settings

    The present study was designed as a single case study exploring enablers and barriers to

    knowledge sharing among professionals working with pharmaceutical development at Novo

    Nordisk R&D, Denmark (Yin, 2003).

    Novo Nordisk is a health care company and a world leader in diabetes care. The company

    has the broadest diabetes product portfolio in the pharmaceutical industry, including the

    most advanced products in the area of insulin delivery systems. Novo Nordisk has a leading

    position in areas such as haemostasis management, growth hormone therapy and hormone

    replacement therapy. In addition, Novo Nordisk has created a drug pipeline for chronic

    inflammatory and autoimmune disorders. With headquarters in Denmark, Novo Nordisk

    employs approximately 26,000 full-time employees in 80 countries, and markets its products

    in 179 countries. More than 4,600 people work in R&D (Novo Nordisk A/S, 2009).

    4.2 Participants

    The participants were staff from the two departments responsible for developing new drug

    products. The key focus of the two departments is to develop the drug product and the drug

    product manufacturing process for further up-scaling in production facilities. These

    responsibilities are allocated throughout the development phases, i.e. preclinical, phases 1,

    2, and 3. The manager empowers the development activities through the team leaders on to

    the scientists and again to the laboratory technicians. The two departments are located at

    different sites approximately 5 km apart.

    The population consisted of professional staff in the two departments, i.e. managers, team

    leaders, principal scientist, scientists, and laboratory technicians. The laboratory

    technicians employed in Department Y were not invited to participate in the workshop.

    Managers, team leaders, principal scientists, and scientists are referred to as scientists in

    the following. The group of scientists has an educational background corresponding to a

    Master of Science or PhD, whereas the group of laboratory technicians in general has a

    three-year long education. In total 60 participants were invited and 47 participated in the

    study. The participants are presented in Table I.

    4.3 Data collection

    The first author carried out the data collection. The participants were invited to workshops

    during normal working hours through Microsoft Outlook. Separate workshops were held for

    the scientists and the laboratory technicians. The agenda item was called knowledge

    sharing. Workshops lasted approximately one hour. During the workshops documentary

    accounts were processed as text. At the workshop participants produced data as text that

    were documented anonymously on post-its (Hodson, 1999). The text was produced

    anonymously in hard-copy as a response to well-defined questions from the first author.

    Participants were asked to identify two organizational knowledge-sharing enablers and

    barriers, respectively. The enablers and the barriers identified were to be related to their

    everyday work life. Lack of time was not allowed for inclusion as a barrier to knowledge

    Table I Participant information

    Department X Department Y Department X & Y Professional group Invited Participated Invited Participated Number of participants

    Managers 1 1 1 1 2Team leaders 3 3 2 2 5Principal scientists and research scientists 18 11 17 14 25Laboratory technicians Not applicable Not applicable 18 15 15

    47

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    sharing (Hendriks, 1999). Additionally, at the workshop, knowledge sharing was explicitly

    defined according to Grant (1996):

    Individuals or groups in an organization that share and combine existing knowledge differently

    with the purpose of creating new knowledge.

    Participation was voluntary and confidentiality with regard to all responses was assured. The

    participants were told that the data were being collected as part of a research study on

    organizational knowledge creation. The documentary accounts were documented

    anonymously on post-its, which were collected later. Following data production on

    post-its the documentary accounts were collected by the first author. Data were collected in2008.

    5. Analysis

    During analysis researcher triangulation was employed. The documentary accounts were

    listed and ordered in groups, themes were labelled and thereafter concepts appeared. To

    increase validity concept building was carried out independently by the researchers. The

    qualitative data were analyzed using meaning condensation: the meanings of the

    documentary accounts were structured around thematic concepts following identification

    of relations between concepts (Kvale, 1996), (Christensen et al., 2008). A description of the

    essence of the documentary accounts was drawn up and given a heading, thus being

    considered a concept before the final concepts were proposed (Christensen et al., 2008).

    Phenomenology was selected as the tradition of inquiry for analyzing the data (Kvale, 1996).Analysis within a phenomenological framework attempts to describe the content and

    structure of the participants consciousness in order to grasp the qualitative diversity of their

    experiences and their essential meanings in relation to the phenomenon (Kvale, 1996). The

    two researchers carried out building of thematic concepts on their own. Figure 1 illustrates

    the procedure for data production, collection, and analysis.

    Thematic concepts were combined with the conceptualization of tacit and explicit

    knowledge as proposed by Nonaka and Takeuchi (1995).

    The concepts that emerged through condensation represent common characteristics of the

    documentary accounts within each concept. Initially several of the documentary accounts

    were shown to represent one or more concepts; condensation was limited to one concept

    per documentary account, however. As a result, some of the concepts may represent a

    broader perspective than that actually expressed. Furthermore, when similar conceptsemerged in both professional groups, they were given the same notation.

    The validity of the research process was assessed by applying the seven stages as

    proposed by Kvale (1996):

    1. theme;

    2. design;

    Figure 1 Procedure for data production, collection and analysis. KS: knowledge sharing

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    3. interview (adapted for this study);

    4. transcription;

    5. analysis;

    6. validation; and

    7. reporting.

    6. ResultsIn the following, the dominant knowledge-sharing enablers and barriers identified for the two

    professional groups are highlighted before the findings are integrated and contrasted. Four

    dominating concepts of knowledge sharing enablers and barriers were identified for each of

    these professional groupings. The group other covered data where no similarities to other

    documentary accounts could be proposed. In Figures 2 and 3 the results are listed in order

    of dominance with the most prevalent concept presented first, illustrated as different sizes of

    circle. The concept other combined single documentary accounts where similarities to

    other documentary accounts could not be proposed. The documentary accounts are

    presented in Tables II-V. Five documentary accounts are presented in each concept where

    possible.

    6.1 Knowledge-sharing enablers scientists and laboratory technicians

    As illustrated in Figure 2, the most dominant concepts of knowledge-sharing enablers

    among the group of scientists were: social relations and network, physical proximity to

    colleagues, no stupid question culture, and meetings and informal spaces. Documentary

    accounts supporting each of these concepts are shown in Table II. For instance, the concept

    Figure 2 Concepts of knowledge-sharing enablers scientists and laboratory technicians

    working in pharmaceutical R&D. KS: knowledge sharing

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    social relations and network is exemplified by the following: To know each other. Easier to

    share/give knowledge to someone you know.

    As illustrated in Figure 2, the most dominant concepts of knowledge-sharing enablers

    among the group of laboratory technicians were: work involvement and interest, things that

    make the job easier, the satisfaction of helping colleagues, and being listened to and taken

    seriously. Documentary accounts supporting each of these concepts are shown in Table III.

    For instance, the concept work involvement and interest is exemplified by the following:

    When I seesomething interesting, exciting or new in my task I become involved and want to

    share my knowledge.

    6.2 Knowledge-sharing barriers scientists and laboratory technicians

    As illustrated in Figure 3, the most dominant concepts of knowledge-sharing barriers among

    the group of scientists were: no physical proximity to colleagues, no one can use the

    knowledge/fear of being considered foolish, knowledge as power, and do not know who

    knows. Documentary accounts supporting each of these concepts are shown in Table IV. For

    instance, the concept no physical proximity to colleagues is exemplified by the following:

    Silo thinking due to physical barriers, e.g. dislocation isolation.

    As illustrated in Figure 3, the most dominant concepts of knowledge-sharing barriers among

    the group of laboratory technicians were: lack of appreciation and attention, no one can use

    the knowledge/fear of being considered foolish, do not know who knows, and knowledge as

    power. Documentary accounts supporting each of these concepts are shown in Table V. For

    instance, the concept lack of appreciation and attention is exemplified by the following: If I

    know people around me do not need my knowledge or I know they do not care about what I

    have found.

    Figure 3 Concepts of knowledge-sharing barriers scientists and laboratoryr technicians

    working in pharmaceutical R&D. KS: knowledge sharing

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    6.3 Relations between concepts and groups

    After integrating and relating the findings, it was possible to illustrate the associations

    relations between the concepts and groups as shown in Figure 4.

    Figure 4 shows that concepts of knowledge-sharing enablers were not the same for the

    groups of scientists and laboratory technicians, although the concepts in both

    professional groups had mutual characteristics. We could see interdependency

    between the concepts related to settings fostering personal closeness, in which

    synergistic influence on knowledge-sharing practices was evident, was seen for the

    scientists. However, we could not see any similar interdependency between the concepts

    identified for laboratory technicians could not be seen. Identical concepts of

    knowledge-sharing barriers (Figures 2 and 3): no one can use the knowledge/fear of

    being considered foolish, knowledge as power, and do not know who knows emerged

    from both professional groups. Contrasting concepts with inverse influence onknowledge-sharing practices were identified for the group of scientists. Oppositional

    influence on knowledge-sharing practices was observed between the concepts social

    relations and network versus do not know who knows and no stupid question culture

    versus no one can use the knowledge/fear of being considered foolish. Contrasting

    concepts for the group of laboratory technicians were not found.

    One obvious concept of knowledge-sharing barriers among scientists mirrored a concept of

    knowledge-sharing enablers, i.e. close versus no physical proximity to colleagues (Figures 2

    Table II Knowledge-sharing enablers for the group of scientists

    Concept Documentary accounts

    Social relations and network Good work collaborations/good personal

    chemistry/personal relationsContact with other people for other purposes

    opportunities to talk about something interestingSeminar outside Novo Nordisk site on relevant specific andnon-specific subjects where there are plenty of breaks

    Social arrangements allow easier contact in futureKnowing each other. Easier to share/pass on knowledge to

    someone you knowPhysical proximity to colleagues Sharing office space with more than two people enforced

    social contact provides opportunities for sharing

    experience makes it more informal to come and ask

    questionsPhysical proximity, e.g. shared officeSitting close together, i.e. along same corridorHaving a work space/desk close to each otherProximity to co-workers and project group members

    No stupid question culture Openness a work environment that stimulates your

    intentionsWhen there is no such thing as stupid questionsOpen atmosphere in the department where it is allowed to

    ask questions

    That it is OK to ask questions to have aknowledge-sharing cultureThat it is legitimate in the present situation/culture to ask

    stupid questions/provide input, even if you dont know

    whether it is relevantMeetings and informal spaces Unplanned meetings, shared facilities/coffee rooms

    Informal culture for personal interactionCoffee rooms and other informal meeting spaceShort face-to-face meetings (or that people sit close

    together knowledge will be shared)Meetings between one or more persons

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    and 3). It was not possible to find a similar pattern of mirroring concepts among the group of

    laboratory technicians (Figures 2 and 3).

    7. Discussion

    7.1 Main findings

    This is the first study to investigate knowledge-sharing enablers and barriers in

    pharmaceutical R&D. The main findings of this study were: important knowledge-sharing

    enablers and barriers were present in the organization and they have become explicit.

    Scientists and laboratory technicians had different views and practices for engaging in

    knowledge-sharing, which revealed that enabling knowledge sharing is multi-facetted and

    that one standard for R&D professionals does not exist. The enablers identified recognizedthe use of tacit knowledge and hence this study has demonstrated that knowledge sharing

    takes place during socialization where individuals interact. This finding suggests that

    individuals in pharmaceutical R&D are an important asset with regard to knowledge sharing

    and hence new knowledge creation in the organization potentially reducing time-to-market.

    The majority of the barriers for engaging in knowledge sharing were similar for the two

    groups. The existence of enablers and barriers with oppositional influence on

    knowledge-sharing practices was evident. Synergy could be identified in the

    knowledge-sharing enablers for the scientists, provided that the settings fostering

    Table III Knowledge-sharing enablers for the group of laboratory technicians

    Concept Documentary accounts

    Work involvement and interest When I see something interesting, exciting or new in my

    task, I become involved and want to share my knowledgeIt is very educational to share knowledge, for me as well as

    the person I am helping. Increased motivation and

    involvementInvolvement/interest from colleagues makes me want to

    share knowledgeDesire to share information wanting to share knowledge

    with othersI need to see the larger meaning in my tasks and to know

    that what I dowillbe used byothers/ to support our common

    goals. That makes me feel involved and I share my

    knowledge and experiencesThe satisfaction of helping colleagues Would like to help

    Like to teach othersTo please others with such little effort, e.g. helping to solve

    an Excel problem. It is good to see their relief after you

    remove the barrierDependency if I know that others are dependent on my

    knowledge before they can continue with their workIf I see that a colleague could do things differently or in an

    easier way, e.g.in the laboratory or in Excel. Then I share my

    knowledgeWhen it gives others an AHA experience

    Things that make the job easier When I have handled a task faster/easier than usualA clever trick to make work easierUtilizing all resources makes daily work easierThe more people who know how my equipment works, the

    more people who can help out when I am ill or on holidayIt is possible to delegate when more people have similar

    knowledge, i.e. more people can handle the same taskBeing listened to and taken seriously Good communication that someone listens to what I have

    to sayIf you come to a person who is open and willing to answer

    questions

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    Table IV Knowledge-sharing barriers for the group of scientists

    Concept Documentary accounts

    No physical proximity to colleagues No physical proximity, e.g. placed at different sitesGeographic distances between officesGreat physical distance between people that are to share

    knowledgeSilo thinking due to physical barriers, e.g. dislocation

    isolation

    Great physical distanceNo one can use my knowledge/fear of Too proud. Do not want to show your ignorancebeing considered foolish Culture where foolish questions are not accepted

    A work environment where employees are insecure about

    expressing themselves an insecure work environmentThinking that others already have the knowledge/cannot

    use your knowledgeDoes anyone need my knowledge? Maybe others alreadyknow? No knowledge of where knowledge is located

    Knowledge as power Wanting to keep your expertise to yourself Opposition to sharing knowledge risk of not feeling

    special anymorePurposely withholding knowledge in order to take the

    creditArrogance/snobbery to make an explanationcomplicated and unintelligible in order to be special

    I know better/people who know it allDo not know who knows Do not know the person who has the knowledge

    Closeddoor do not know the organization who is doing

    what?Too little knowledge about others tasks and goalsIf people do not know or meet each other do not know

    that the others know somethingSpecific groups (project groups or teams) not knowing

    that useful knowledge exists

    Table V Knowledge-sharing barriers for the group of laboratory technicians

    Concept Documentary accounts

    Lack of appreciation and attention If there is no openness to questions refusalIf I know people around me do not need my knowledge or I

    know they do not care about what I have discoveredIf people do not use my knowledgeIf I forget to send an e-mail containing knowledgeInattention to the value of knowledge sharing

    No one can use my knowledge/fear of

    being considered foolish

    The more people have studied, the more intelligent they

    are I probably dont have anything to contributeIf other people take up too much space with all their

    knowledge then I cannot be heardScared of saying something wrong will look a foolI feel that I do not have all the facts and that prevents me

    from sharing knowledgeMy experience is not that important or useful to share with

    othersKnowledge as power I f you do not share al l the information if you hold

    something backA know-it-all attitudeKnowledge is power

    Do not know who knows Youhavetohavesome knowledgetoknow whattoask or

    know what others might need. Otherwise no knowledge is

    sharedFinding the right target groupHearing about the problem when its too late

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    personal closeness to colleagues were stimulated. The impact of physical proximity to

    colleagues on knowledge-sharing practices was therefore noteworthy.

    7.2 Enablers to knowledge sharing

    The enablers identified recognized the use of tacit knowledge. Although similar or related

    concepts of knowledge-sharing enablers can be found in the literature, the perspectives of

    scientists and laboratory technicians in pharmaceutical development have not been

    explored specifically in qualitative research (Cardinal and Hatfield, 2000; Leenders and

    Wierenga, 2002; Thompson and Heron, 2006; Kneller, 2003; Nerkar, 2003; (Chang et al.,

    2007). In one empirical study, Sundgren et al. (2005) have identified that information sharingplays an important role in creativity in pharmaceutical R&D. The questionnaire used in that

    study did not uncover the enablers of information sharing, however.

    In the SECI model, the socialization mode refers to sharing tacit knowledge requiring some

    kind of connection between the persons involved. For the scientists in the present study, the

    most dominant concept of knowledge-sharing enablers was related to social relations and

    network. These findings indicate that knowledge-sharing practices in R&D primarily take

    place through human interactions. Sharing of tacit knowledge as a key component in

    Figure 4 Overview of knowledge-sharing enablers and barriers and their contrasts KS: knowledge sharing

    KS enablers Scientists KS barriers Scientists

    KS enablersLaboratory technicians

    Work involvementand interests

    Things that makethe job easier

    The satisfaction ofhelping colleagues

    Being listened to

    and taken seriously

    Knowledge

    as power

    Do not knowwho knows

    Mirrored concepts

    Identical concepts

    Contrasting conceptswith oppositionalinfluence on KS

    Contrasting conceptswith oppositionalinfluence on KS

    Interdependency withsynergistic influence

    on KS

    No one can usemy knowledge/fear

    of being foolish

    Lack of attentionand appreciation

    Do not knowwho knows

    Knowledgeas power

    No one can usemy knowledge/fear

    of being foolish

    No physical proximityto colleagues

    KS barriersLaboratory technicians

    Social relationsand network

    Physical proximityto colleagues

    No stupidquestion culture

    Meetings andinformal spaces

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    knowledge creation processes has also been confirmed in pharmaceutical R&D (Nerkar,

    2003; Kneller, 2003), and in biotech (Sapsalis et al., 2006). In an empirical study carried out

    in various non-pharmaceutical industries, McDermott and ODell (2001) found that a network

    for sharing knowledge builds on existing networks people use in their daily work. Another

    empirical study, this one conducted by Schulze and Hoegl (2006), reported similar findings.

    Their study showed that the socialization mode was crucial in the concept phase of new

    product development in different industries (automobile and medical devices). Here

    knowledge sharing can be interpreted as the seed of new knowledge creation.

    The knowledge-sharing enablers in this study demonstrate interdependencies withsynergistic influence on knowledge sharing. These links are valuable as it may take very

    little effort to significantly increase the impact on knowledge-sharing practices, e.g. common

    open space to increase personal closeness, which then reinforces the frequency of informal

    meetings and the exchange of tacit knowledge. These findings are to some extent consistent

    with those in the empirical literature. Here the importance of meetings and informal spaces in

    relation to knowledge-sharing practices were proposed as important settings for fostering a

    certain level of personal closeness to help overcome distance. Once again this finding

    stimulates the dimension of sharing tacit knowledge (Corti and Lo Storto, 2000; Napier and

    Ferris, 1993; Schulze and Hoegl, 2006). Open-space offices in pharmaceutical R&D have

    demonstrated to enable sharing of tacit knowledge (Boutellier et al., 2008).

    Interdependencies with synergistic influence between the identified knowledge-sharing

    enablers for the group of laboratory technicians were not found. In addition, the concepts

    that emerged were different from those of the scientists. The divergence inknowledge-sharing enablers between the two professional groups indicates different

    goals, job responsibilities, personal views, and practices for participating in

    knowledge-sharing activities. This supposition is supported by the finding of mutual

    characteristics of knowledge-sharing enablers within each professional group. The

    characteristics of knowledge-sharing enablers for the laboratory technicians were related

    to soft values and to a work smarter not harder mind-set. For scientists, enabler

    characteristics were more closely related to work settings. Different views on

    knowledge-sharing practices and their characteristics have not previously been studied in

    a qualitative study in pharmaceutical R&D.

    The dominant concept of knowledge-sharing enablers identified for the laboratory

    technicians was related to work involvement and job interest. Although in an empirical

    study Dewett (2007) found self-efficacy and work interest to be fundamental to creativity, the

    study did not deal with knowledge sharing. The R&D employees in Dewetts study included

    both scientists and technical staff. The present study suggests additionally that

    knowledge-sharing practices are enhanced if the activity makes the job easier and helps

    colleagues. These findings indicate that knowledge-sharing practices also have a strong

    collegial focus. In pharmaceutical R&D softer values such as employee commitment and

    care have earlier been suggested as knowledge-sharing enablers (Thompson and Heron,

    2006; Styhre et al., 2002). In other industrial fields such as consulting employee commitment

    has also been identified as a knowledge-sharing enabler (Van den Hoof and de Leeuw van

    Weenen, 2004).

    7.3 Barriers to knowledge sharing

    In the pharmaceutical industry where development cycles are long, knowledge-sharingbarriers are suggested to be an obstacle to the creation of new knowledge. The majority of

    the identified barriers to knowledge sharing were similar in the two professional groups.

    Although on the whole similar views of barriers to knowledge sharing have not been

    described earlier, the individual concepts can be related to recent literature. Bartol and

    Srivastava (2002) and ODell and Grayson (1998), respectively, described the power of

    knowledge and knowledge about who knows. Concern about who can use ones knowledge

    and the fear of being considered foolish has previously been proposed as barriers. A

    mistrustful atmosphere has been proposed as a barrier (Von Krogh et al., 2000) as well as

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    beliefs such as not having valuable information relevant to others (Cabrera and Cabrera,

    2002).

    Physical distance to colleagues was identified as a noteworthy barrier as well as being

    mirrored as a knowledge-sharing enabler, obviously depending on proximity. Similar

    findings have been found in the software industry (McLaughlin et al., 2008). These findings

    of this present emphasize that physical proximity to colleagues has an obvious impact on

    knowledge-sharing practices for the group of scientists. This supports the SECI model

    confirming that knowledge sharing takes place during socialization as point of departure for

    knowledge creation. The findings are further supported by the physical location of R&D

    departments at different sites. Leenders and Wierenga (2002) have previously described

    the importance of physical proximity to colleagues in the pharmaceutical industry and in

    biotech (Zeller, 2001; Poti, 2001). Napier and Ferris (1993) have also confirmed these

    findings in a non-pharmaceutical setting. Similar concepts for the group of laboratory

    technicians were not found.

    It is clear from this study that the knowledge-sharing barriers identified for the group of

    scientists have an oppositional impact on some of the knowledge-sharing enablers

    identified. For instance, if someone does not know who knows, perhaps he or she does not

    have the proper network. Or if someone has a fear of being seen as foolish, that would

    reinforce the knowledge-sharing enabler of a culture where no stupid questions exist. These

    reinforcements are suggested to inhibit the socialization processes. The opposing impact on

    knowledge-sharing practices that has been identified within the concepts of

    knowledge-sharing enablers and barriers underscores the importance of these conceptsfor the group of scientists. These findings are in agreement with a study from the steel

    industry demonstrating that lack of knowledge about where knowledge was available was a

    knowledge-sharing barrier (Gupta and Govindarajan, 2000).

    It is suggested that appreciation is facilitated by informal networks, because they stimulate

    appreciation of individuals. However, in this study the laboratory technicians did not

    explicitly correlate appreciation from colleagues with informal networks.

    7.4 Knowledge sharing in relation to the SECI model

    The proposed enabling concepts were primarily related to aspects of tacit knowledge, i.e.

    the socialization mode of the SECI model. Nonetheless, the findings of this study show there

    is more to the SECI model than tacit and explicit knowledge. The SECI model does not

    account for the actions of individuals such as their strategies, practices, and goals. Although

    a relationship between individuals is a precondition for knowledge-sharing practices

    (Szulanski, 1996; Hansen et al., 1999), this precondition is not part of the SECI model. With

    regard to knowledge sharing in relation to SECI model, the model lacks the views and values

    of the individuals for engaging in knowledge-sharing practices. Other authors have pointed

    out similar shortcomings of the SECI model (Gourlay and Nurse, 2005). Gourlay and Nurse

    (2005) argue that the theory cannot explain how the mind produces ideas or fails to do so. In

    addition, Von Krogh et al. (2000) suggest that a high degree of caring among colleagues is

    particularly important in the sense of sharing tacit knowledge, but neither dimension is

    reflected in the SECI model.

    8. Conclusions and implications

    The results of the present study are based on a single case study and have relevant

    managerial implications. This study adds to the understanding of knowledge sharingbetween different professional groups working in pharmaceutical R&D. The findings have

    implications for both theory and practice.

    Over the course of the research process, it became evident that tacit organizational

    knowledge had become explicit. Important knowledge-sharing enablers and barriers were

    present in the organization. This study showed that R&D professionals have experienced

    different views and practices for engaging in knowledge-sharing, which reveals that

    enabling knowledge sharing is multi-faceted and that one standard for R&D professionals

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    does not exist. The identified knowledge-sharing enablers recognized the use of tacit

    knowledge. Synergism was identified for the enablers and the existence of barriers with

    oppositional influence on these enablers was clear. Implementing the synergistic enablers

    therefore helps increase the knowledge-sharing practices and minimize the identified

    barriers. Physical proximity to colleagues was an important factor for the identified

    knowledge-sharing enablers.

    The results of this research have practical relevance. First, managers should be aware of the

    diversity of the professionals, such as their different views and practices regarding

    knowledge-sharing enablers and barriers. The awareness and acknowledgement of these

    diversities can positively influence knowledge sharing in R&D and hence the new knowledge

    creation processes. Second, managers should focus on the value of the synergism of

    knowledge-sharing enablers and the oppositional influence of the barriers that cause

    knowledge-sharing practices to fail. Third, due to the social embedding of tacit knowledge,

    managers should consider the location of their R&D employees. All these issues contribute

    to the time a company spends on the development cycle. Focusing on knowledge-sharing

    activities in pharmaceutical R&D may potentially reduce time to market. The SECI model was

    found to have some limitations as the model does not include the actions of employees and

    their inter-unit relationships. However, the SECI model inspired the data analysis and was

    utilized for the conceptualization of tacit and explicit knowledge.

    There are limitations to how far empirical findings can be generalized. Further research

    should be conducted to investigate how knowledge-sharing practices are related to

    knowledge creation processes during the development of new drug products. Moreover,studies should be carried out in other settings. A multiple case study in pharmaceutical R&D

    could contribute to wider generalization of the findings.

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    About the authors

    Anne-Mette Lilleoere was a PhD student (January 2007-January 2010) at The Faculty ofPharmaceutical Sciences, University of Copenhagen, Denmark. Anne-Mette Lilleoere is thecorresponding author and can be contacted at: [email protected]

    Ebba Holme Hansen is Professor at the Section for Social Pharmacy, Faculty ofPharmaceutical Sciences, University of Copenhagen since 1992 and the driving forcebehind the development of social pharmacy as an academic discipline. Professor HolmeHansen is an expert in both qualitative and quantitative research methods and has authored15 books and more than 200 scientific articles, chapters in books and reports.

    PAGE 70 jJOURNAL OF KNOWLEDGE MANAGEMENT j VOL. 15 NO. 1 2011

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