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Slide 1The Nest Group, Inc.
• high quality glass columns• for lab scale to process scale• solvent resistant and/or biocompatible
design• designed for low, medium and high
pressure column chromatography
Kronlab Glass Columns
Slide 2The Nest Group, Inc.
Product Lines
• Eco– lab scale – low / medium pressure
• ECOPLUS
– extended pressure rating up to 80 bar
– lab scale to prep
• Classic– lab scale– medium pressure– conical tube
• BioCart– lab scale to prep– glass cartridges– medium to high pressure
• Pilot– pilot scale to production
scale– custom designed – solvent resistant or for
aqueous buffers
Slide 3The Nest Group, Inc.
Pilot Columns for Pilot to Production Scale
Slide 4The Nest Group, Inc.
Pilot Columns for Pilot to Production Scale
• designed for use in pilot and production scale• designed for use with organic solvents (version SR) or
aqueous buffers (version AB)• outstanding flow distribution for a linear flow
distribution profile• high precision manufacturing of plungers and
distribution plates with CNC milling machines, no injection moulding involved
Slide 5The Nest Group, Inc.
Pilot Columns for Pilot to Production Scale
• full documentation for validation• full service and support for custom designed columns• materials are in compliance with FDA regulations CFR
21, certified if needed• precise and reliable height adjustment of the piston
with hand wheels• mounted either on castors or fixed stand or directly into
customer´s plant
Slide 6The Nest Group, Inc.
Pilot Columns - Wetted Materials
• column tube: calibrated borosilicate glass or stainless steel (steel quality to customer‘s specification); optional acrylic
• piston: PE, PTFE, PVDF or stainless steel• seals: EPDM or Kalrez®• frits: PE, stainless steel, others on request
Slide 7The Nest Group, Inc.
Pilot Columns - Sizes
• columns from 60 mm to 600 mm ID• length on demand
Slide 8The Nest Group, Inc.
Pilot Column -Design of Flow Distributor
flow distribution profile proofed by Bayer AG and Kronlab GmbH
Slide 9The Nest Group, Inc.
Pilot Column -flexible inner diameters
Flow distribution profile proofed by Bayer AG and Kronlab GmbH
PI 60
PI 100PI 100 Cooling Jacket
PI 140
PI 450
Slide 10The Nest Group, Inc.
Pilot Column -flexible column material
stainless steel
glass or acrylic
Slide 11The Nest Group, Inc.
Pilot Column -flexible pressure ranges
1 bar
8,7 bar
10 bar
50 bar
Slide 12The Nest Group, Inc.
Pilot Column -integration of user demands
e.g. rotable frames, integrated level indicator, brackets, selected materials, connectors ……….
Slide 13The Nest Group, Inc.
Pilot Columns -
Custom Designspecial solutions for individual needs regarding:
• materials
• design
• size
• system integration
Slide 14The Nest Group, Inc.
Pilot Columns -
Custom Design
• individual feasibility studies and technical drawings
• certification
• competent guidance throughout the whole project
Slide 15The Nest Group, Inc.
Pilot AB - rotatable
column id: 200 mm
max. bed height: 1600 mm
pressure rating: 7 bar
specially designed rotatable frame construction
Slide 16The Nest Group, Inc.
Pilot SR – solvent resistant
technical specifications:
column id: 200 and 300 mmmax. bed height: 400 mmpressure rating: 1.5 bar
explosion-proof environment with antistatic protection and wheels
Slide 17The Nest Group, Inc.
Pilot SR – stainless steel
technical specifications:
column id: 100 mmmax. bed height: 1000 mmmin bed height: 500 mmpressure rating: 40 barsealing: Kalrez®
Slide 18The Nest Group, Inc.
Pilot SR – stainless steel
technical specifications:
column id: 150 mmmax. bed height: 900 mmmin bed height: 700 mmpressure rating: 50 barsealing: Kalrez®
Slide 19The Nest Group, Inc.
Pilot AB - Reactor
id: 300 mmbed height: 0- 500 mmpressure rating: 1 barfrit: 30 µm
(SS 1.4404)
special features:• slurry inlet• integrated magnetic stirrer on cambered bottom frit• piston with scraper• special designed column stand
Slide 20The Nest Group, Inc.
Pilot AB -rotatable
id: 240 mmbed height: 0 - 270 mmvolume: 0-12 lpressure rating: 3 barcooling jacket: 15 - 65°CSS - container: 15 l for slurry wastefrits: 10 µm PE
5 mm thicknessspecially designed frit fastening screwsto ensure perfect flow distribution
Slide 21The Nest Group, Inc.
Pilot Columns - stainless steel
id: 600 mm
max. bed height: 1000 mm
(1500 mm)
bed volume: 282,6 l
(423,9 l)
pressure rating: 10 bar
frits: 10 µm
Slide 22The Nest Group, Inc.
ExamplePilot Column - stainless steelid: 600 mmmax. bed height: 1000 mm
(1500 mm)bed volume: 282,6 l
(423,9 l)pressure rating: 10 barfrits: 10 µm
designed for repeated packing and unpacking without opening the column
Slide 23The Nest Group, Inc.
Solvent Inlet
Solvent Outlets
Slurry-Outlet through central outlet valve
Example
Slurry-Inlet through separate slurry pump
Slide 24The Nest Group, Inc.
Pilot Columns - References• Abbott• Aventis• Baxter Hyland Immuno AG• Bayer AG• Biotest• Clariant• Genetics Institute • Genzyme • Honeywell• Novartis AG • Schering AG• Roche Diagnostics• etc …