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Systemic Diseases and the Skin
By: Dr. Kazhan Ali Tofiq Kadir
December 2011
The following is a summary of systemic diseases most commonly encountered in practice which manifest themselves by changes in the skin:
hyperlipidaemia
Skin manifestations of hyperlipidaemia include: flat yellow deposits around the eye (xanthelasma). Elsewhere on the body they present as yellowish papules or nodules called xanthoma. Sudden eruptions can appear in large numbers over the buttocks, trunk and limbs, or a few larger lesions can develop on the elbows, knees, hands and over the Achilles tendon.
Gastrointestinal disease
Inflammatory bowel disease
This can include pyoderma gangrenosum and erythema nodosum. Oral manifestations include aphthous stomatitis, mucosal nodularity (cobblestoning) and pyostomatitis vegetans
(.erythematous thickened mucosa)
Carcinoid syndrome
Cutaneous metastases can present as deep nodules, hyperkeratosis and pigmentation changes similar to those seen in pellagra ( Niacin/ Vitamine B 3
deficiency).
Diabetes mellitus
Recurrent skin infections are common, either due to fungi (e.g. genital candidiasis) or bacteria (e.g. folliculitis). Blisters on the feet may be found as granuloma annulare. when these blisters develop the
condition is called bullosis diabeticorum
Brown macules sometimes develop on the shin
Necrobiosis lipoidica diabeticorum can also occur on the shins. The lesions have the appearance of plaques with dark red or purple edges, atrophic centres and on the surface. we may see telangiectasia
Liver disease
The cutaneous manifestations characteristically includeJaundice Erythema of the palms Purpura
Spider naevi Generalised itching
Lichen planus is known to be linked to hepatitis C infection .
Human immunodeficiency virus/acquired immunodeficiency syndrome
A variety of skin conditions can occur in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS)
•DermatitisThe appearance can resemble psoriasis, Reiter's Disease or seborrheic dermatitis and has
been termed 'psoriasiform dermatitis of AIDS’
Infections Bacillary angiomatosis is a treatable
infection caused by a rickettsia-like organism
Viral infections such as chronic herpes zoster can also occur
•Malignancy
' Kaposi s sarcoma is an AIDS-defining illness characterized by initial bruise-like macules developing into brown-red or purple firm-to-hard nodules. In AIDS these are widespread, especially on the face and trunk.
Sarcoidosis Sarcoidosis can present with erythema
nodosum, or with plaques, papules or nodules. The latter are commonly seen as smooth, dark brown/violaceous lesions arranged in an annular pattern. Infiltration of an old scar is characteristic so that it becomes brightly purple coloured. Lupus pernio is a slowly developing form that spreads into large areas of plaque on the chin and nose that results usually in clear
deformity.
Mastocytosis
This is a condition in which there is proliferation of mast cells. In the skin it can cause single or multiple, dark red nodules or plaques that develop into a blister or wheal when rubbed. This is commonest in babies. It can also cause urticaria pigmentosa either as skin wheals in infancy often following a bath, or extensive areas of dark brown macules that swell and go red when stroked in adults.
Amyloidosis Amyloidosis appears in middle age with
bruising, petechiae and purpura related to deposition of amyloid in the dermal blood supply. This is most frequently seen in the anogenital, periorbital and peri-umbilical regions, at the side of the neck and in the axillae. Atrophic waxy lesions with areas of purpura inside them may sometimes be seen, or as shiny smooth firm flat topped papules of waxy colour .
The tips of the fingers may exhibit softening and loosening of the skin. A case of advanced primary amyloidosis presenting as a non-healing leg ulcer has also been reported.
Cutaneous amyloidosis is associated with various autoimmune/immune disorders and associations with sarcoidosis and IgA nephropathy have been reported .
Acromegaly
Cutaneous changes in acromegaly can include skin puffiness, oily skin with large pores, hypertrichosis, pigmented skin tags, acanthosis nigricans and psoriasis. Skin creases in the head area are deeper than normal (cutis verticis gyrata or ‘ Klingon (head ‘
Hypopituitarism
The skin is dry, scaly and puffy and the nails become brittle. The hair is coarse and sparse, especially in the axillae. Fine wrinkles around the eyes and mouth are typical.
Hypothyroidism
The skin in myxoedema is cool to the touch, doughy, dry and puffy and there may be hair loss. Peri-orbital oedema may be accompanied by a yellowish colour to the skin.
Hyperthyroidism
The skin in thyrotoxicosis is the obverse of that seen in myxoedema. It is warm and moist and flushing of the face and palms is sometimes seen. Pre-tibial myxoedema is characteristic .
Cushing's syndromeAbdominal striae may be a prominent feature, caused by skin atrophy. The skin may bruise easily and skin infections and acne may be frequent problems. Skin darkening may occur in the palmar creases, on areas subject to pressure and the axillae.
Porphyria
There are a number of different forms of porphyria, e.g. porphyria cutanea tarda, erythropoietic porphyria. All are characterized by photosensitivity, with fragility and blistering of the skin when exposed to sunlight or ultraviolet rays .
Rheumatoid arthritis
Rheumatoid nodules - subcutaneous lumps seen near an affected joint – occur in about 25% of the patients. The phenomena include thinning of the skin, translucency of the skin on the back of the hands, brittle nails which split lengthwise
and reddened palms erythema ).)
Dermatitis in which neutrophils are prominent on biopsy neutrophilic dermatosis may present as erythematous areas, and interstitial granulomatous dermatitis is a rare condition in which rheumatoid papules may appear on the trunk. Cutaneous vasculitis may present as purpuric areas on the skin.
Reiter's disease
Keratoderma blennorrhagicum is sometimes seen in this condition. It is characterised by hyperkeratotic lesions on the palms of the hands or the soles of the feet. Clear vesicles on an erythematous base develop which then progress to macules, papules and nodules. The lesions may be impossible to distinguish from pustular psoriasis .
Myelodysplastic syndrome
Various cutaneous manifestations can occur including leukaemia cutis, photosensitivity, prurigo nodularis and purpura. Cutaneous conditions are thought to indicate that the patient belongs to a high-risk group, associated with bone marrow transformation and hypergammaglobulinaemia .