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Cancer Immunology
SBM 3033
Ridhwan Abdul Wahab
10/12/2012
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Evidence for tumor immunity
spontaneous regression
regression of metastases after removal of primary tumor
infiltrations of tumors by lymphocytes and macrophages
lymphocyte proliferation in draining lymph nodes
increased cancer risk after immunosuppression and
immunodeficiency
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Introduction
tumor cells differ from normal cells => recognition as
foreign
immune responses fail to prevent tumor growth
external activation of the immune system
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Cancer Talking.....
tumor cells differ from normal cells => recognition as
foreign
immune responses fail to prevent tumor growth
1. derived from host cells.
2. rapid growth/spread.
3. have specialised mechanisms in Evading.
external activation of the immune system
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Cancer Chat....
tumor cells differ from normal cells => recognition as
foreign
immune responses fail to prevent tumor growth
external activation of the immune system
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Identification of Tumor Ag recognised by T lymphocytes.
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Tumor antigens
mutations
abnormal expression
oncogenic viruses
oncofetal antigens
altered surface modifications
tissue specific differentiation antigens
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Tumor antigens - Mutations
point-mutations
deletions
translocations
insertions
specific for tumor cells
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Figure 14-12
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p53
http://en.wikipedia.org/wiki/P53
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Tumor antigens
mutations
abnormal expression
oncogenic viruses
oncofetal antigens
altered surface modifications
tissue specific differentiation antigens
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Figure 14-13
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Figure 14-11 part 1 of 2
Origin of tumor antigens
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Figure 14-11 part 2 of 2
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Overview
Introduction
Tumor antigens
Immune response
Evasion of immune responses
Immunotherapy
Role of immune system in promoting tumor growth
Summary
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Immune responses to tumors
innate immune responses
NK cells
macrophages
adaptive immune responses
T cells
antibodies
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Overview
Introduction
Tumor antigens
Immune response
Evasion of immune responses
Immunotherapy
Role of immune system in promoting tumor growth
Summary
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Figure 14-14 part 1 of 2
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Figure 14-14 part 2 of 2
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Overview
Introduction
Tumor antigens
Immune response
Evasion of immune responses
Immunotherapy
Role of immune system in promoting tumor growth
Summary
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Immunotherapy
stimulation of immune response
vaccination with tumor cells
costimulators and cytokines
block inhibitory pathways
nonspecific stimulation of the immune system
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Tumor vaccines
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Cytokine gene transfection
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Systemic cytokine therapy
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Immunotherapy
passive immunotherapy
adoptive cellular therapy
graft-versus-leukemia
antibodies
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Monoclonal antibodies
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Figure 14-17
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Overview
Introduction
Tumor antigens
Immune response
Evasion of immune responses
Immunotherapy
Role of immune system in promoting tumor growth
Summary
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Promoting tumor growth
chronic inflammation as risk factor for cancer