LAC953-04/00 PER!l!LORDETl!YLENE: MULTI GENERATION ... · lac953-04/00 . per!l!lordetl!ylene: multi...

LAC953-04/00

PER!l!LORDETl!YLENE: MULTIGENERATION JNHALATION STUDY IN THE RAT

INDIVIOOAL AN1MIIL DATA SUl'PLl!MNr

APPENDIX 7

REPRDWCTIVE PEREORMANCE - FO GENERATION

300 Pfiil YOtJt>K; YOtJt>K; YOtJt>K; YOtJt>K;GEST'N MALE YOtJt>K:: M YOUNG FEMALE PAJ:RJN:; +VE :::MEliR PCI DATE

ALIVE ALIVE PERIOD Nl.MBER DAY ONE ALIVE ALIVE ALIVE Nl.MBER DATE DATE LITTERED DAY 29 (DAYS) ALIVE DEAD DAY 5 DAY 11 DAY 16 DAY 22

97121 20/07/92 26/07/92 6 10/08/92 11/08/92 1 98

98 122 20/07/92 22/07/92 2 0 12 12 12 12 12 12/08/92 13/08/92 1 04/09/92 22 102 14

8 19/08/92 22 99 14 0 12 12 12 12 12123 20/07/92 28/07/92

100124 20/07/92 22/07/92 2 10 10 10 10 1012/08]92 13/08/92 1 04/09/92 22 110 10 0

8 22 101 8 1 8 8 8 8 125 20/07/92 26/07/92 6 17/08/92

23 102 4 0 4 4 4 4 4126 20/07/92 22/07/92 2 14/08/92

103127 20/07/92 26/07/92 6 16/08/92 17/08/92 1 113

104 1 0 0 128 20/07/92 26/07/92 6 18/08/92 23

0 5 5 5 5 5 129 20/07/92 21/07/92 1 12/08/92 22 105 5

0 3 3 3 3 3 130 22 106 3 20/07/92 22/07/92 2 13/08/92

7 7 0 7 7 7 7 131 20/07/92 27/07/92 7 18/08/92 22 107

132 20/07/92 21/07/92 1 10810/08/92 11/08/92 1 105

133 20/07/92 21/07/92 1 1090 10 10 10 10 10 10/08/92 13/08/92 3 04/09/92 22 lll 10

9 110 9 0 9 9 9 9 134 20/07/92 22/07/92 2 12/08/92 21

8 8 0 8 8 8 8 135 20/07/92 21/07/92 1 12/08/92 22 lll

n -1 r--...-o-... ..,. 0\0.....

w 010

LAC953-04/00

PERC!lLOROETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE BAT

INDIVIDUAL AN1MAL DATA SUPPLEMENT

APPENDJX 7

REPRDOOCTIVE PERFOFMAN:::E - FO GENERATION

300 ppn

Fl!MALE NU1BER

PAIRING DATE

+VE 91EAR DATE

PCI DATE GEST'N MALE YOUNG N1 YOUNG LI'!TERED PERIOD NU1BER DAY ONE ALIVE

(DAYS) ALIVE DEAD DAY 5

YOUNG ALIVE DAY 11

YOUNG ALIVE DAY 16

YOUNG ALIVE DAY 22

YOUNG ALIVE DAY 29

136

137

138

139

140

20/07/92

20/07/92

20/07/9210/08/92

20/07/92

21/07/9210/08/92

21/07/92

23/07/92

21/07/9211/08/92

21/07/92

22/07/9211/08/92

1

3

1 1

1

1 1

12/08/92

14/08/92

02/09/92

12/08/92

22

22

22

22

lJ2

113

114 lJ2

113

105 120

12

14

11

13

0

0

0

0

12

13

10

13

12

13

10

13

12

13

10

13

12

13

10

13

12

13

10

13

141

142

143

144

20/07/9214/08/92

20/07/9210/08/92

20/07/92

20/07/92

24/07/9218/08/92

21/07/9211/08/92

23/07/92

21/07/92

4 4

1 1

3

1

09/09/92

14/08/92

12/08/92

22

22

22

117 106

118 ll5

119

120

9

14

11

0

0

1

9

14

11

14

10

9

14

10

8

14

10

8

14

10

n -I r......., .......,. 0

"'....,

w

"" .....

LAC953-04/00

PERCHLORDETHYLENE: MULTIGENERATION INHALATION STIJDY IN THE RAT

INDIVIIJIJAL ANlMIIL DATA SUPPLEMENT

APPENDJX 7

REPRDW::TIVE PERFOlll1110CE - FO GENERATION

1000 PIJll

FEMALE PAIRJN:; +VE :'11EAR PCI DATE GEST'N MALE YQUN:; Kr YQUN:; YOUNG YQUN:; YQUN:; YQUN:; NU1BER DATE DATE LITTERED PERIOD NtMBER ll'IY ONE ALIVE ALIVE ALIVE ALIVE ALIVE

(DAYS) ALIVE DEAD DAY 5 DAY 11 DAY 16 DAY 22 DAY 29

169 20/07/92 25/07/92 5 16/08/92 22 145 11 2 10 10 10 10 10

170 20/07/9215/08/92

25/07/9216/08/92

5 1 07/09/92 22

146 162 15 0 14 14 14 13 13

171 20/07/9210/08/92

22/07/9212/08/92

2 2 03/09/92 22

147 160 12 0 12 12 12 12 12

172 20/07/92 21/07/92 1 12/08/92 22 148 4 0 4 3 3 3 3

173 20/07/92 23/07/92 3 14/08/92 22 149 9 2 9 9 9 9 9

174 20/07/92 21/07/92 1 150

175 20/07/92 22/07/92 2 13/08/92 22 151

176 20/07/9210/08/92

21/07/9212/08/92

1 2 03/09/92 22

152 152 10 0 7 6 6 6 6

177 20/07/92 21/07/92 1 12/08/92 22 153 13 2 12 12 12 12 12

178 20/07/9210/08/92

21/07/9213/08/92

1 3 05/09/92 23

154 150 12 2 11 11 11 11 11

179 20/07/92 21/07/92 1 12/08/92 22 155 7 0 7 7 7 7 7

180 20/07/92 22/07/92 2 13/08/92 22 156 13 0 13 13 13 13 13

181 20/07/92 22/07/92 2 13/08/92 22 157 13 1 12 11 10 10 10

182 20/07/92 23/07/92 3 14/08/92 22 158 9 2 7 7 7 6 6

183 20/07/92 22/07/92 2 12/08/92 21 159 7 0 5 5 4 4 4

184 20/07/92 21/07/92 1 12/08/92 22 160 11 2 7 7 7 7 7

"--1 r..._.,..._..,. 0

"' .....,

w 0"\ N

LIIC953-04/00

PERCHLORDETI!YLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT

INDlVIIXlAL ANn1AL DATA SUPPLEMENT

APPENDIX 7

REPROOO:::TIVE PERFORMANCE - FO GENERATION

1000 IJ!IIl

mw.E Nll1BER

PAIRING DATE

+VE SMEAR PCI DATE

DATE GEST'N MALE YOUNG Kr YOUNG LITTERED PERIOD Nll1BER DAY ONE ALIVE

(DAYS) ALIVE DEAD DAY 5

YOUN3 ALIVE DAY ll

YOUNG ALIVE DAY 16

YOUNG ALIVE DAY 22

YOUNG ALIVE DAY 29

185 20/07/92 21/07/92 1 12/08/92 22 161 6 0 6 6 6 6 6

186 20/07/92 21/07/92 1 13/08/92 23 162 3 0 3

187 20/07/9210/08/92

21/07/9212/08/92

1 2 03/09/92 22

163 153 16 1 16 16 16 16 16

1aa 20/07/9210/08/92

21/07/9214/0a/92

1 4 05/09/92 22

164 155 9 0 9 a a a

1a9 20/07/92 23/07/92 3 14/08/92 22 165 12 0 12 12 12 12 12

190 20/07/9216/0a/92

23/07/92 3 166 165

191 20/07/92 22/07/92 2 13/0a/92 22 167 13 0 13 12 12 12 12

192 20/07/92 22/07/92 2 14/0a/92 23 16a 1 2 0

("") -i r...... '"0.._.., 0

"" ......

w 0'> w

-,,

···-------· ···------··

PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANIMAL DATA SUPPLEMENT

APPENDIX 8

CLINICAL OBSERVATIONS (LITTERS PER SYMPTOM) - FlA PUPS

The incidence is presented as the number of pups affected per litter.

Key:

X = present L = left R = right

CKD = checked

CTL/P/4097 - 364

LAC955-02/02

PERCHLORDETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL ANIMIIL DATA SUPPLEMENT

APPENDIX 8

CLINICAL OBSERVATIONS (LITTERS PER SJ:MPTCM) - F1A PUPS

GROUP NO: 4

CLINICAL OBSERVATION: FOUND DEAD (CIINNillt\LISED) BODY SYSTEM: DEATH

DP:f DP:fDP:f DP:f ll<\Y ll<\Y DP:f DP:f M:lTHER NO. SEVERITY DP:f DP:f DP:f 6 7 10 11 16 17 18 20OF LITTER CODE 1 2 5

1 191 X

(")_,r-c

~0

......

----""

"'w U1

LAC955-02/02

PERCHLOROETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL ANIMAL DATA SUPPLEMENT

APPENDIX 8

GROUP NO: 1

CLINICAL OBSERVATIONS (LITI'ERS PER SYMPm1) - F1A PUPS

BODY SYSTEM:

MJTHER NO. SEVERITY OF LITI'ER CODE

29 X

DFATH

DAY 1

1

DAY 2

1

DAY 5

DAY 6

DAY 7

CLINICAL OBSERVATION:

DAY DAY 10 11

FOUND DEAD

DAY 16

DAY 17

DAY 18

DAY 20

42 X 1

('"} -< r ....... "0 ....... """ 0

"'....,

w "' "'

~. ~

LAC955-02/02


INOIVI!JUAL ANIMAL JlA.TA SUPPLEMENT

APPENDIX 8

CLINICAL OBSERVATIONS (LITI'ERS PER SYMP'll:M) - FlA PUPS

GROUP NO: 2

BODY SYSTEM: IlEIITll CLINICAL OBSERVATION: FOUND DEAD

MJTHER NO. OF LITI'ER

SEVERITY CODE

DAY 1

DAY 2

DAY 5

DAY 6

DAY 7

DAY 10

DAY 11

DAY 16

DAY 17

DAY 18.

DAY 20

82 X 1

87 X 1

92 X 4 n -l

' --o -""0 \0 .....

w "'.....

LAC955-02/02

PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY lN THE RAT

lNDIVIIXJAL ANIMAL DATA SUPPLEMENT

APPENDIX 8

GROUP NO: 3

CLINICAL OBSERVATIONS (LI'I'l'ERS PER SYMPTCM) - F1A PUPS

BODY SYSTEM: DFATH CLINICAL OBSERVATION: FOUND DEAD

MJTHER NO. OF LI'I'l'ER

125

SEVERITY CODE

X

DAY 1

1

DAY 2

DAY 5

DAY 6

DAY 7

DAY 10

DAY 11

DAY 16

DAY 17

DAY 18

DAY 20

144 X 1

,..., -l,...... -c ........, 0

""......

w "'CXl

,-,

LAC955-02/02

PERCHLOllDEI'HYLENE: MDLTIGENERATION INIW..IITION STUDY IN TilE RAT

INDIVIDUAL i\N:IMAL llAIA SUPPLEMENT

APPENDlX 8

CLINICAL OBSERVATIONS (LITI'ERS PER SYMP'l1l1) - F1A PUPS

GROUP NO: 4

BODY SYSTEM: DEATH CLINICAL OBSERVATION: FOUND DEAD

MlTHER NO. OF LI'ITER

SEVERITY OODE

DAY 1

DAY 2

DAY 5

DAY 6

DAY 7

DAY 10

DAY 11

DAY 16

DAY 17

DAY 18

llliY 20

169 X 2 1

172 X 1

173 X 2

176 X 1

177 X 2

178 X 2

181 X 1 1

182 X 2

184 X 2

186 X 1

187 X 1

192 X 2

" -1

' ........., ........,. 0 0.0 .....

w 0> 0.0

LAC955-02/02

PERCHLOROETHYLENE: MIJLTIGENERATION IN!lALATION STUDY IN THE RAT

INDIVI:ruAL AN1MAL DATA SUPPLEMENT

APPENDlX 8

CLINICAL OBSERVATIONS (LI'ITERS PER SYMPICM) - F1A PUPS

GROUP NO: 3

BODY SYSTEM: DEATl! CLINICAL OBSERVATION: KILLED IN EXTREMIS

l1JTHER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY OF LI'ITER CODE 1 2 5 6 7 10 11 16 17 18 20

141 X 1

(""') -I.-........, .........,. 0

"' ....,

w...., 0

~',

LAC955-02/02

PEilCHLOROETIIYLENE: MULTIGENERATION INHAlATION STUDY IN TilE RAT

INDJ:IIIOOAL liNIMAL DATA SUPPLEMENT

APPENDIX 8

GROUP NO: 4

CLINICAL OBSERVATIONS (LITIERS PER SYMPTCMl - F.lA PUPS

BODY sYSTEM: DEATH CLINICAL OBSERVATION: KILLED IN EXTREMIS

MJT!!ER NO. OF LITIER

SEVERITY CODE

DAY 1

DAY 2

DAY 5

DAY 6

DAY 7

DAY 10

DAY 11

DAY 16

DAY 17

DAY 18

DAY 20

186 X 1

n --! r -" -..,. 0 '-D.....,

w...., .....

LAC955-02/02

PERCHLORDE'l'llYLENE: MULTIGENERATION INHALATION STUDY lli THE RAT

INDIVIIJUAL l\NJMAL DATA SUPPLEMENT

APPENDIX 8

GROUP 00: 1

CLINICJ\L OBSERVATIONS (LITTERS PER SY!1l"KM) - FlA PUPS

BODY SYSTEM:

M)THER 00. OF LITIER

D

SEVERITY CODE

EATH

DAY 1

DAY 2

DAY 5

DAY 6

DAY 7

CLINICJ\L OBS

DAY 10

ERVATION:

DAY 11

MISSIN:;,PRESlliED

DAY 16

DEAD

DAY 17

DAY 18

DAY 20

25 X 5 1

26 X 1

34 X 1

39 X 1

43 X 1 1

44 X 3

45 X 1

46 X 1

"-l........, ........,. 0

'"' ......

...... ....., N

LAC955-02/02

PERCHLOROE'I'HYLENE: MULTIGENERATION lNHALATION STUDY IN THE RAT

OOIVIDJAL ANIMAL DATA SUPPLEMENT

APPENDIX 8

CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F1A PUPS

GROUP NO: 2

BODY SYSTEM: DEATH CLINICAL OBSERVATION: MISSING,PRESlliED DEAD

MJTHER NO. OF LITI'ER

SEVERITY CODE

DAY 1

DAY 2

DAY 5

DAY 6

DAY 7

DAY 10

DAY 11

DAY 16

DAY 17

DAY 18

DAY 20

78 X 2

81 X 1

82 X 1

84 X 1

85 X 1

90 X 1

91 X 1

92 X 2

93 X 1

"-i r........., .........,. 0

"" ......

w ...... w

LAC955-02/02

PERCHLOROETHYLENE: MIJLTIGENERATION INHALATION STUDY 1N THE RAT

lNDIVIIJIJAL iiNlMAL DATA SUPPJ.,J;MENT

APPEND1X 8

CLlNICI\L OBSERVATIONS {LITTERS PER SYMPTCM) - F1A PUPS

GROUP NO: 3

BODY SYSTEM: DEATH CLINICAL OBSERVATION: MISSING,PRESU1ED DEAD MJTHER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAYOF LITTER CODE 1 2 5 6 7 10 11 16 17 18 20

122 X 2

123 X 2

128 X 1

137 X 1

138 X 1

144 X 1 1

.....n r-......."tl.........,. 0\0....,

w....,..,.

-,

LAC9SS-02/02

PERCHLORDETHYLENE: MULTIGENER!\TION INHAlATION STUDY lli THE RAT

INDIVID.!AL ANIMAL D.<\TA SUPPLEMENT

APPENDIX 8

GROUP 00: 4

CLlliiCAL OBSERVATIONS (LITTERS PER SYMPTCM) - FlA PUPS

BODY SYSTEM: DEATH CLlliiCAL OBSERVATION: MISSIN:;,PRESU1E!J DEAD

M:lTHER 00. OF LITI'ER

170

SEVERITY OODE

X

DAY 1

DAY 2

DAY 5

1

DAY 6

DAY 7

DAY 10

DAY 11

DAY 16

DAY 17

DAY 18

DAY 20

176 X 2 1

177 X 1

178 X 1

181

182

X

X

1

2

1

183

184

X

X

2

4

1

186 X 1

188 X 1

192 X 1

" .....,..... -c ......,. 0 <.0....,

w...., <.T1

Lt\C955-02/02

PERCHLORDE'l'HYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANlMI\1 DATA SUPPLEMENT

APPENDIX 8

GROUP NO: 4

CLINICAL OBSERVATIONS CLITI'ERS PER SYMP'I'CM) - F1A PUPS

BODY SYSTEM:

M:lTHER NO. SEVERITY' OF LITI'ER CODE

DEATH

DAY 22

DAY 23

DAY29

CLINICAL OBSERVATION: MISSING,PREStl1ED DEAD

182 X 1

,.., -! r ....... -o .......... 0

""....,

w...., 0>

~-

LAC;JJ-02/02

PERCHLORDETHYLENE: MULTIGENERATION INHALAl'ION STUDY lli TilE RAT

INDIVIDUAL ANIMAL DATA SUPPLEl1ENT

APPENDIX 8

CLINICAL OBSERVATIONS (LITI'ER.S PER S'iMPTCMl - FlA PUPS

GROUP NO: 1

BODY SYSTEM: EYES GENERAL CLINICAL OBSERVATION: CHRJ:MJ!lliCRYORR!IEA MJTilER NO. SEVERITY DAY DAY DAYOF LITI'ER OODE 22 23 29

48 L 1

"-1....--..,.""'0

"""

w""

LAC955-02/02

PERCHLORDETHYLENE: MDLTIGENERATION IN!!liLATION STUDY IN THE RAT

INDIVIru\L AN.ll1AL DATA SUPPLEMENT

APPENDIX 8

CLINICAL OBSERVATIONS (LITIERS PER SlliPTCM) - F1A PUPS

GROUP NO: 3

BODY SYSTEM: E'iES GENERAL CLINICAL OBSERVATION: CHRCMJllACRYOllBHE'A

MJTHER. NO. OF LITTER

SEVERITY OODE

DAY 22

DAY 23

DAY 29

136 L R

1 1

139 L R

3 1

('""') -; r.._ '"0 .........,. 0 1.0....,

w ..... ():)

,

UIC955-02/02



APPENDIX 8

CLINICAL OBSERVATIONS (LITI'ERS PER SYMP'IU1) - F1A PUPS

GROUP NO: 4

CLINICAL OBSE!WATION: CHR!MJDACRYORRHFABODY SYSTEM: EYES GENERAL

illTHER NO. SEVERITY DAY DAY DAYOF LITTER CODE 22 23 29

169 R 1

-n-ir "t:>

"""0-\0......

w......\0

LAC955-02/02

PERCHI..ORDETHYLENE: MIJLTIGENERATION INl!J\J.ATION STUDY IN THE RAT

INDIVIIXJAL ANlMAL DATA SllPPLEMENT

APPENDIX 8

GROUP NO: 4

CLINICAL OBSERVATIONS <LITTERS PER S'rMPTCM) - F1A PUPS

BODY SYSTEM:

MJTHER NO. SEVERITY OF LITTER CODE

EYES GENERAL

D!iY 22

D!iY 23

D!iY 29

CLINICAL OBSERVATION: DISCHARGE FR£M EYE

171 R 1

187 L 1

n -I r...._ '"t:l...._.., 0

""....,

w co 0

LAC955-02/02

PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIX!AL ANlMAL DATA SUPPLEMENT

APPENDIX 8

GROUP 00: 1

CLINICAL OBSERVATIONS (LITTERS PER SYMPTCMl - FJA PUPS

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: COLD

MJTHER 00. OF LI'ITER

41

SEVERITY CODE

X

DAY 1

1

llo\Y 2

DAY 5

DAY 6

DAY 7

DAY 10

DAY ll

DAY 16

DAY l7

DAY 18

DAY 20

44 X 2

46 X 4 (") -i ........_ -o..._ ..,. 0

"" .....,

w CXJ .....

LAC955-02/02


INDIVIllUAL ANlM8L DATA SUPPLEMENT

APPENDIX 8


GROUP NO: 2

BODY SYSTEM: GENERAL OONDITION CLINICAL OBSERVATION: OOLD

MJ1'HER NO. SEVERITY OF LITI'ER OODE

DAY DAY 1 2

DAY 5

DAY 6

DAY 7

DAY DAY 10 11

DAY 16

DAY 17

DAY 18

DAY 20

95 X 1

C'") -; r ...... '"0 ........,. 0

...... "'

w co N

~

PERCHLOROE'lliYLENE: MULTIGENERATION INHALATION STUDY IN THE RATINDlVIlX!AL ANIMAL llATl\. SUPPLEMENT

APPENDIX 8 CLINICliL OBSERVATIONS (LITI'ERS PER SYMPTCMl - E1A PUPSGROUP 00: 3

BODY SYSTEM: GENERAL CONDITION CLINICliL OBSERVATION:MJTllER 00. COLDSEVERITY DAY DAY OF LITTER DAY CODE DAY1 D.>\¥ 2 DAY 5 DAY 6 DAY 7 DAY10 DAY DAY 11 122 16X 17 18 2 20

139 X 1 144 X 2

u i-02/02

("")

-----ir"1:1

0-"' 1.0...., I

w00w

PERCBLOROETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDJAL .ANlMI\L DATA SllPl'LEMENT

APPENDIX 8

CLINICAL OBSERVATIONS (LIITERS PER SIMP'l'CM) - F1A POPS

GROUP NO: 4

CLINICAL OBSERVATION: COLDBODY SYSTEM: GENERAL CONDITION

DAY DAY DAY DAY DAY DAY DAY DAY

DAY DAY DAY I-OTHER NO. SEVERITY 17 18 20 5 7 10 11 16 2 6 OF LITI'ER CODE 1

2 171 X

176 X 1

183 X 1

191 X 1

1 192 X

l..AC955-02/02

(")-1r----.,.,.0....,""

OJw.,.

PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN '!HE RAT IND1VIIXIAL ANIMAL DATA SUPPLEMENT

APPENDIX 8

CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCMl - FlA PUPSGROUP NO: 1

BODY SYSTEM: GENERAL OONDITION CLINICAL OBSERVATION: HIND LlMB Illll1tlGEDMJTHER NO. SEVERITY DAY DAY DAY DAY OF LITI'ER DAYOODE DAY 1 DAY 2. DAY 5 DAY 6 DAY7 DAY 10 ll 16 17 18 2.0 39 L 2

IX 12/02.

'"'.......-ir "'0.........,0<0.......

wOJc..n

LAC955-02/02

PERCHLOROEI'HYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 8

CLINICAL OBSERV.ATIONS (LITTERS PER SYMPTCM) - F1A PUPS

GROUP NO: 1

BODY SYSTEM:

M)TilER NO. SEVERITY OF LI'ITER OODE

GENERAL OONDITION CLINICAL OBSERV.ATION: PALE

DAY DAY DAY DAY DAY DAY DAY DAY 1 2 5 6 7 10 11 16

DAY 17

DAY 18

DAY 20

39 X 1

(") ..... r ...... -o ........,. 0

"' ....

w co "'

"~

PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT INDIVIDUAL ANlMAL U'ill\ SUPPLEMENT

APPENDIX 8

CLINICAL OBSERVATIONS (LITJ'ERS PER SYMP'IU1) - F1A PUPSGROUP NO: 1

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: SMALLM)'I'HER NO. SEVERITY !lilY !lilY !lilY OF LITTER !lilYOODE !lilY !lilY1 !lilY 2 5 !lilY !lilY 6 7 !lilY !lilY 10 11 16 17 18 20 25 X 1

44 X 1

LA -02/02

("')_,,....._ "0..._.,.0lO.....

wco.....

U\C955-02/02

PERCHLOROETHYLENE: MIJLTIGENERATION INliALIITION STUDY IN THE RAT

INDIVIOOAL AN1MAL DATA SUPPLEMENT

APPENDIX 8

CLINICAL OBSERVATIONS (LITTERS PER SYMPTCM) - FlA PUPS

GROUP 00: 1

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: OMAIL

MlTHER 00. OF LITI'ER

SEVERITY CODE

DAY 22

DAY 23

DAY 29

39 X 1

("") ..... ........ ' "0 .........,. 0 \0 .....

w 00 00

_.....,-...._,

l'ERCHLORDETllYLENE: MULTIGENERATION INHALATION STIJDY IN THE RAT INDIVIDIAI.. AN1MAL DATA SUPPLEMENT

APPENDIX 8 CLINICAL OBSERVATIONS (LITTERS PER SYMP'ICM) - FlA PUPS

GROUP NO: 2

BODY SYSTIM: GENERAL CONDITION CLINICAL OBSERVATION: S1ALLMlTHER NO. SEVERITY DAY DAY DAYOF LITTER DAY CODE DAY DAY1 DAY 2 DAY 5 DAY 5 DAY7 10 DAY 11 15 17 1875 20 X 1

91 X 1

LA! 02/02

('"').....r......"'0.......,.0.....,"'

w(X)

"'

LAC955-02/02


INDI.VIOOAL 1\NlMAL DATA SUPPLEMENT

APPENDIX 8

CLINICAL OBSERVATIONS (LITrERS PER SYMP'lll1) - FJA PUPS

GROUP NO: 2

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: SMALL

M:lTHER NO. OF LITIER

SEVERITY CODE

DAY 22

DAY 23

DAY 29

87 X 1

("') -; ..._' "C..._..,. 0

......

w

"'

0"'

PERCHLOROETHYLENE: MULTIGENERATION INHAUITION STUDY IN TilE RAT INDIVIDUAL ANJMIIL DATA SUPPLEMENT

APPENDIX 8 CLlNICI\L OBSERVATIONS (LITJ'EilB PER SYMP'ILM) - F1A PUPS

GROUP l'KJ: 3

BODY SYSTEM: GENERAL CONDITION CLlNICI\L OBSERVATION: S1ALLM:lTHER m. SEVERITY lli\Y lli\Y lli\Y OF LITTER lli\Y CODE lli\Y 1 lli\Y 2 lli\Y5 lli\Y 6 7 lli\Y lli\Y 10 lli\Y 11 16 17129 18 X 20 1

u -02/02

("")-1r ......"'0........,.0....,"'

w

"'....


JNDIVIIJUAL ANIMAL DATA SUPPLEMENT

APPENDIX 8

CLINICAL OBSERVATIONS (LlTIERS PER SYMPTCM) - FJA PUPS

GROUP 00: 4

CLINICAL OBSERVATION: S!1\I.L BODY SYSTEM: GENERAL OONDITION

DAY 00 DAY DAY DAY DAY DAY DAY MlTHER NO. SEVERITY DAY DAY DAY 11 16 17 18 20 6 7 10 OF LITI'ER OODE 1 2 5

1 1 1 170 X

2 1171 X

2173 X

1 3176 X

12177 X

3180 X

5181 X 1

7182 X

5183 X

6 1184 X

6185 X

15187 X

188 X 1 1

3189 X

11191 X

(")

.-...........-o...... 0"""<.0.....,

w<.0N

LAC955-02/02

-·------, --

LAC ~2/02

PERCHLOROETHYLENE: l1ULTIGENERATION INHALATION STUDY IN THE RAT INDIVI!lUAL ANIMAL DATA SUPPLEMENT

APPENDlX 8

CLINICIIL OBSERVATIONS (LITTERS PER SYMPTCMl - F1A PUPSGROUP NO: 4

BODY SYSTEM: GENERAL CONDITION CLINICIIL OBSERVATION: S1ALLMJTHER NO. SEVERITY DAY DAY DAYOF LI'ITER CODE 22 23 29 171 X 1 2 191 X 12 1

"-1r...._-c..........0<.0....,

w<.0w

LAC955-02/02

PERCHLOROETHYLENE: MIJLTIGENERATION INHALATION STUDY JN THE RAT

INDIVIIXJAL liNIMI\L DATA SUPPLEMENT

APPENDIX 8

CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - FlA PUPS

GROUP NO: 1

BODY SYSTEM: GENERAL CONDffiON CLINICAL OBSERVATION: TAll.. DAMtiGED

MYl'llER NO. OF LI'ITER

SEVERITY CODE

DAY 1

DAY 2

DAY 5

DAY 6

DAY 7

DAY 10

DAY ll

DAY 16

DAY 17

DAY 18

DAY 20

46 X 1

,..., -;....... -o .......,. 0 0.0 ......

w 0.0.,.

~-

LAC. 02/02


INDIVIDUl\L ANJMAL DATA SUPPLEMENT

APPENDIX 8

CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F1A PUPSGROUP N:J: 1

BODY SYSTEM: GENERAL OONDITION CLINICAL OBSERVATION: TAIL I:W1AGEDMlTHER N:J. SEIJERI1Y DAY DAY DAYOF LITI'ER OODE 22 23 29

38 X 1

('")

.-;...._-o...._..,0<0....,

w<0U1

LAC955-02/02

PERCffi..OROETHYLENE: Mill..TIGENERATION J:NHAI.ATION STUDY IN THE RAT

INDIVIDUAL ANIMAL DATA SUPl'.LEM:NT

APPENDlX 8


GROUP NO: 2

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: TAIL l:W1i\GED

MJTHER NO. SEVERITY 00 00 00 00 00 00 00 00 DAY DAY 00 OF LITI'ER CODE 1 2 5 6 7 10 11 16 17 18 20

91 X 1 1 1

r, -i, ......., ...... c3 ....., ""

w

"" "'

LAL -02/02

PERCHLOROET!!YLENE: MULTIGENERATION INHALATION STUDY lN THE RAT

INDIV!lltW.. ANJM.AL DATA SUPPLEMENT

APPENDIX 8

CLJNICIIL OBSERVATIONS (LITTERS PER SMTCM) - F1A PUPS GROUP 00: 2

BODY SYSTEM: GENERAL CONDITION CLJNICIIL OBSERVATION: TAIL JlAMAGEDM)TIJER 00. SEVERITY DAY DAY DAYOF LI'ITER CODE 22 23 29

77 X 1

91 X 1 1

r n-<

'"tl--...01.0....,

w1.0....,

LAC955-02/02

PERCHLOROETIIYLENE: M!JLTIGENERATION INHAI..ATION STUDY IN THE RAT

INDIVIOOAL ANIMAL DATA SUPPLEMENT

APPENDIX 8

CLINICAL OBSERVATIONS (LITl'ERS PER SYMPTCM) - FlA PUPS

GROUP 00: 3

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: TAIL JlliMAGElJ

MJTHER 00. OF LITTER

SEVERITY CODE

Jl.\Y 22

Jl.\Y 23

Jl.\Y 29

137 X 1

("") .... ;...._ "0...._ ... 0

....."'

w ex:>"'

~

PER!E..OROETHYLENE: MULTIGENERATION lNHALATION STUDY IN THE RAT


APPENDIX 8

CLINICAL OBSERVATIONS (LITTERS PER SYMP'ICM) - F1A PUPS

GROUP NO: 4

BODY SYSTEM: GENERAL OONDITION CLINICAL OBSERVATION: TAll. DAMAGED M:lTilER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY OF LITTER OODE 1 2 5 6 7 10 11 16 17 18 20

179 X 1 191 X 1 1

L8C9~5-02/02

("")-1

-..r -o.........,.0

"'""

w

'""'""

UC955-02/ 02

PERCHLORDEI'HYLENE: MIJLTIGENERATION lNHALATION STUDY IN TilE RAT

INDIVIlllTAL ANlMAL DATA SUPPI..EMENT

APPENDIX 8


GROUP NJ: 1

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: SEE FREE TEXT

MmlER NJ, SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY OF LITI'ER OODE 1 2 5 6 7 10 ll 16 17 18 20

29 X 1

n -< ....... ' "0 ....... 0""' ....,'""

0 ""' 0

J.IIC955-02/02

PERCHLORDET!IYLENE: MDLTIGENE:RATION INH8I.ATION STUDY IN THE RAT

INDlV!llUAL AN.IMAL llii.TA SUPPLEMENT

APPENDIX 8

CLINICAL OBSERVATIONS (LITTERS PER SYMPTCM) - F1A PUPS

GROUP NO: 3

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: SEE FREE TEXT

MJTHER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY OF LITIER CODE 1 2 5 6 7 10 11 16 17 18 20

123 X 1

n -< r.._ -c.._..,. 0 1.0...,

..,. 0 ......

LAC955-02/02

PERCHLOROETHYLENE: Ml.ll..TIGENERATION INHAI.ATION STUDY IN THE RAT

INDIVID.lAL ANlMAL DATA SUPPLEMENT

APPENDIX 8

GROUP NJ: 4


BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: THIN

MlTiiER NJ, SEVERITY OF LITI'ER CODE

170 X

183 X

DAY DAY 1 2

DAY 5

DAY 6

DAY 7

DAY DAY 10 11

1

DAY 16

DAY 17

DAY 18

DAY 20

1

("") -I r...... ""' ...... ~ 0 <0.....,

~ 0 N

~~

LI\C9:>5-02/02

PERCHLOROE1'HYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 8

CLINICAL OBSERVATIONS (LITI'ERS PER SYMP11l1) - F1A PUPS

GROUP NO: 1

BODY sYSTEM: RESPIRATORY SYSTEM CLINICAL OBSERVATION: BREATHING IRREGULAR MlTHER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAYOF LITI'ER OODE 1 2 5 6 7 10 11 16 17 18 20

33 X 1

"-i........,,

......""'01.0.....,

..,.0w

UC955-02/02

PERCHLOROETHYLENE: MI.lLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIXIAL ANlMAL DI\TA SUPPLEMENT

APPENDIX 8

CLINICAL OBSERVATIONS (LITTERS PER SYMPTCM) - FJA PUPS

GROUP ID: 2

BODY SYSTEM: RESPIRATORY SYSTEM CLINICAL OBSERVATION: BRFATHING IRREGULAR

MJTHER 00. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAYOF LITIER CODE 1 2 5 6 7 10 11 16 17 18 20

95 X 1

("") -;,.... ....... .......""' ... 0 <.0....,

... 0...

-~

-----. ....- ------------------

LAC955-02/02

PERCHLORDETHYLENE: MIJLTIGENElWI.'ION INHALATION STUDY IN THE RAT

INDIVm!AL 1\NlM.IIL DATA SUPPLEMENT

APPENDIX 8

CLINICAL OBSERVATIONS (LITTERS PER SYMPTCMl - F1A PUPS GROUP 00: 3

BODY SYSTEM: RESPIRATORY SYSTEM CLINICAL OBSERVATION: MOCUS SECRETION FR£M IDSEMJTHER ID. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY OF LITTER DAY DAYCODE 1 2 5 6 7 10 11 16 17 18 20

131 X 1

("")......r ......'"0.........01.0.....,

...0<n

LAC955-02/02

PERCHLOROETHYLENE: MDLTIGENERATION JNHALATION STUDY IN THE RAT

INDIVIDUAL .IINJMM. DATA SUPPLEMENT

APPENDIX 8

CLINICAL OBSERVATIONS (LITTERS PER S'1MPTCM) - F1A PUPS

COMMENT PAGE

CCM1ENTS: MJT!IER NO. DAY NO. CCM1ENT

25 ll ONE FE1ALE PUP VlRDNGLY SEXED DAY 5 SHOUUJ BE MALE.

25 16 ONE FE1ALE PUP VlRDNGLY SEXED DAY 5 SHOUUJ BE MALE.

29 1 BOTH HIND IJMBS AND BASE OF TAIL SIDILEN AND DARK RED/BLACK IN COLOUR.

37 5 ONE MALE SEKED VlRDNGLY ON DAY ONE.

37 ll ONE MALE SEXED VlRDNGLY ON DAY ONE.

37 16 ONE MALE SEKED VlRDNGLY ON DAY ONE.

37 22 ONE MALE SEXED VlRDNGLY ON DAY ONE.

38 16 COUNTED VlRDNGLY PREVIOUS TIME.FE1ALE IS PRESENT.

39 23 ONE PUP SEXED VlRDNGLY LAST TJME, 10 FE1ALES AND 1 MALE

41 5 ONE FE1ALE SEXED VlRDNGLY ON DAY ONE.

43 5 DAY 5 (AFTERNOON) 1 MALE PUP KILLED ACCIDENT.

43 ll DAY 5 (AFTERNOON) 1 MALE PUP KILLED ACCIDENT.

43 16 DAY 5 (AFTERNOON) 1 MALE PUP KILLED ACCIDENT.

45 5 DAY 5 - ONE PUP VlRDNGLY SEXED DAY 1 SHOUUJ BE MALE

45 16 DAY 5 - ONE PUP VlRDNGLY SEXED DAY 1 SHOUUJ BE MALE

85 ll DAY ll ONE PUP EXTRA (MALE) •

85 22 DAY ll ONE PUP EXTRA (MALE) •

91 5 LITTER COUNT FOR DAY 5 ACTUAlLY RECORDED ON DAY 7.

n -i.-....... -o ....... 0""" .......""

0 """ 0'>

~

CCM1ENTS: --------

MJTHER ID. DAY ID. CCM1ENT

93 5 ONE MALE WRONGLY SEXED DAY 1.

122 5 ONE FE1ALE SEXED WRONGLY ON DAY ONE.

123 1 SKIN TORN ON INNER LEFT THIGH.IDT BLEEDING.

125 5 ThO MALES WRONGLY SEXED DAY 1 SHOULD BE FE1ALES.



137 5 DAY 1 ONE FE1ALE SEXED WRONG SHOULD BE MALE.

141 18 CLIN-OBS FOR PUP KILLED - HEAD SIDILEN, HUNCHED, SUBDUED, PlLOERECTION

143 5 DAY 1-ThO FE1ALES WRONGLY SEXED SHOULD BE MALE.

172 6 FOUND DE'All AFIER FIRST DAY OF EXPOSURE (DAY 6) •

176 5 ONE PUP WRONGLY SEXED DAY 1 SHOULD BE MALE

181 6 FOUND DE'All ATFER EXPOSURE.

184 16 ONE MALE FOUND EXTRA DAY 16.



191 5 DAY 2 SEXES CKD FOUND TO BE 9 MALES AND 4 FE1ALES.

191 16 ONE MALE PUP FOUND EXTRA SJNCE DAY 11.

LAC955-02/02

PERCffi.DRDE'l'llYLENE: MULTIGENERATION INHALATION STUDY IN TilE RAT

INDIVIIXW.. ANIMAL DATA SUPPLEMENT

IIPPENDIX 8

CLlNICAL OBSERVATIONS (LITTERS PER SYMPTCM) - l'1A PUPS

COMMENT PAGE

-1 " .-....... "'C ....... 0""' ....,'""

0""' ....,

(



APPENDIX 9

BODYWEIGHTS (g) BY LITTER TO DAY 29 POST PARTUM- FlA PUPS

The litters from dam numbers 45 (day 11) 1 48 (day 11) 1 85 (day 16) 1 91 (day5) and 188 (day 16) were not weighed in error.

The litter from dam number 39 was weighed on day 23 and not on day 22 inerror. The litter from dam number 141 was weighed on day 12 and not on day11 in error.

The litters from dam numbers 89 and 91 were weighed on day 17 in additionto day 16 in error.

Key:

CNT = count (number of pups)WT = weight M = male F = female

CTL/P/4097 - 408

(

LAC950-03 I06

PERCHLORDETHYLENE: l1IJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIXL\L ANlMAL DATA SUPPLEMENT

liPPENDIX 9

BODYWEIGHTS (g) BY LITI'ER TO ll!\Y 29 rosT PARTU1 - F1A PUPS MALES FEMALES

DI'M PUP INDIVIDUAL WEIGHTS ll!\Y NO: 1 MEAN CNT. MEAN CNT. NU1BER SEX 0 PIJll wr. wr.

25 M 4.8 5.3 5.4 5.7 5.8 5.40 5 F 4.1 4.1 5.0 5.2 5.2 5.2 5.3 5.5 4.95 8

26 M 5.2 6.4 6.5 6.8 6.9 7.0 6.47 6 F 5.8 6.0 6.4 6.4 6.15 4

28 M 5.7 6.2 6.3 6.07 3 F 4.8 4.9 5.3 5.4 5.5 5.7 5.27 6

29 F 7.0 7.00 1

30 M 8.7 9.0 8.85 2 F 9.0 9.00 1

31 M 5.8 6.3 6.05 2 F 5.2 5.20 1

32 M 6.0 6.1 6.6 6.7 6.35 4 F 5.5 6.0 6.0 6.1 6.1 6.7 6.07 6

33 M 5.4 5.6 6.1 6.3 6.8 6.9 6.18 6 F 5.4 5.6 5.8 5.9 6.0 6.6 5.88 6

34 M 6.3 6.8 6.55 2 F 5.4 5.5 5.6 5.7 5.8 5.9 6.0 6.1 5.75 8

35 M 5.4 5.9 6.1 5.80 3 F 4.1 4.8 5.1 5.3 5.4 5.5 5.7 5.8 6.2 5.32 9

36 M 5.8 6.2 6.3 6.6 6.7 6.7 6.8 6.44 7 F 5.2 5.7 5.7 6.1 6.2 6.3 5.87 6

37 M 5.2 5.6 5.7 6.3 6.4 5.84 5 F 5.1 5.7 5.8 5.8 5.8 5.9 6.2 6.4 5.84 8

I ]'

to

(")_, .... ...... '"0 .......,. 0 <0 .......

cr I

s

?

.,. 0 <0

I"

''

I o

/::_

I~

!.]

LAC950-03/06

PERCill.OROE'l'HYLENE: M!JLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANlMAL DATA SUPPLEMENT

APPENDIX 9

DAM NU1BER

PUP SEX 0 ppn

BODYWEIGHTS (g) BY

INDIVIDUAL

LITI'ER TO fillY 29

WEIGHTS

POST PARTtM - FlA PUPS

fillY NO: 1 MALES MEAN wr.

FEM.<\LES CNT. MEAN

wr. CNT.

38 M F

5.8 5.0

6.0 5.0

6.0 5.6

6.1 6.2 6.6 6.0 6.3

6.12 6 5.58 5

39 M F

4.3 4.3

5.6 4.4 4.5 4.6 4.7 4.8 4.9 4.9 4.9 5.1

4.95 2 4.71 10

40 F 6.5 7.5 7.6 7.20 3

41 M F

5.6 5.3

5.7 5.4

6.0 5.4

6.0 5.5 5.5 5.7 6.2

5.83 4 5.57 7

42 M F

5.6 5.7

5.8 5.8

6.2 5.8

6.3 6.5 6.7 6.9 5.9 6.0

6.29 7 5.84 5

43 M F

5.1 4.9

5.2 5.4 5.4 5.5 5.6 5.6 5.6 5.9 5.9 5.9 5.55 ll 4.90 1

44 M F

5.6 3.6

6.3 5.2

6.4 5.5

6.5 5.8

6.7 5.8 6.0 6.1

6.30 5 5.43 7

45 M F

5.8 4.5

6.8 6.2

7.1 6.6

7.2 6.6

7.2 6.6

7.7 7.2

6.97 6 6.28 6

46 M F

5.7 5.0

5.9 5.3

6.0 5.6

6.1 5.9

6.1 6.4

6.2 6.6

6.00 6 5.80 6

47 M F

5.3 5.8

5.8 6.3

5.9 6.8

7.3 7.3

7.4 7.6 6.55 6 6.55 4

48 M F

5.8 5.6

6.1 5.6

6.1 5.6

6.4 5.9

6.10 4 5.68 4

:/

l'z_

.J n -; r-.. "'0-...., 0 u::>....,

i ?

I~£ ~~

I '?.

.., ..... 0

. ~

' -·

I r_.

.()

---- -·- ---- --~ -----·

LAC950-03 06 I

PERCHLOROETHYLENE: MULTIGENERATION lNHALATION STUDY IN THE RAT

INDIVIOOI\L ANIMAL DATA SUPPLEMENT

APPENDIX 9

ll'M NlMBER

PUP SEX 0 ppn

BODYWEIGHTS (g) BY LIITER TO DAY 29 POST PARTIM - E1A PUPS

INDIVIDUAL WEIGHTS DAY NO: 1 MALES MEAN wr.

EEMALES CNT. MEAN CNT. wr.

GROUP SlM1ARY MEAN

S.D.

COUNT 21

6.22 102

0. 75 0 5.91 122

0.91 0

23

("') ..... r....... -o ....... <§; \0...,

""' ...... ......

LAC950-03/06

PERC!ILORDETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL ANlMAL DATA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTIM - F1A PUPS

DAM N\MlER

PUP SEX 0 pp;n

INDIVIDUAL WEIGHTS DAY 00: 5 MALES MEAN wr.

FEMALES 00. MEAN 00. wr.

25 M F

4.3 5.2

6.0 5.7

6.0 6.0

6.3 6.2

5.65 4 5.78 4

26 M F

9.1 9.1

9.4 9.2

9.6 9.2

10.0 9.4

10.4 9.70 5 9.23 4

28 M F

9.0 7.5

9.4 7.5

9.8 7.9 8.1 8.3 8.5

9.40 3 7.97 6

30 M F

13.0 13.9

13.8 13.40 2 13.90 1

31 M F

8.6 7.2

8.7 8.65 2 7.20 1

32 M F

7.4 7.6

7.8 7.8

8.3 7.9

8.8 8.0 8.1 8.8

8.08 4 8.03 6

33 M F

6.8 7.0

7.4 7.5

8.1 8.3

8.1 8.4

8.4 8.9

8.6 8.9

7.90 6 8.17 6

34 M F

11.1 9.6

11.2 9.8 9.9 10.3 10.5 10.6 10.7

11.15 2 10.20 7

35 M F

9.2 7.1

9.4 7.9

9.5 8.6 9.2 9.3 9.4 9.5 9.5 10.0

9.37 3 8.94 9

36 M F

9.0 8.2

9.3 8.4

9.4 8.9

9.5 9.1

10.1 9.5

10.2 9.7

10.3 9.69 7 8.97 6

37 M F

7.7 8.2

8.4 8.3

8.4 8.3

8.7 8.4

8.8 8.6

9.3 8.6 9.1

8.55 6 8.50 7

('")

-< r-.... ""-....... 0

"'....,

... ..... N

- :? c

I

'T ?

_)

_;>

io

~. ~

n.....r......."0........,.0\0....,

.,......w

LAC9~0-03/06


INDIV:IIIUAL ANIMIIL Dll:rA SUPPLEMENT

APPENDIX 9

BODYWEIG!ITS (g) BY LITI'ER TO DAY 29 POST PARTIM - F1A PUPS MALES FEMALESJlAM PUP INDIVIDUAL WEIGHTS DAY ID: 5 MEAN CNT. MEAN CNT.NU1BER SEX 0 ppn wr. wr.

38 M 7.8 8.0 8.0 8.5 8.5 9.2 8.33 6F 7.2 7.3 8.0 8.1 8.3 7.78 5 39 M 7.1 8.0 7.55 2F 6.3 6.3 6.6 6.9 7.0 7.0 7.2 7.3 8.3 6.99 9 40 F 10.7 12.3 12.4 U.80 3 41 M 9.4 9.S 10.0 9.63 3F 8.8 8.8 9.1 9.2 9.3 9.6 9.7 10.1 9.33 8 42 M 8.4 8.8 8.9 9.1 9.6 9.7 10.0 9.21 7F 8.6 8.8 8.9 9.0 9.1 8.88 s43 M 7.9 8.3 8.6 8.6 9.2 9.3 9.3 9.4 9.S 9.6 8.97 10F 8.6 8.60 1 44 M U.2 u.s 12.0 U.S7 3F 8.9 9.9 10.1 10.2 10.7 U.O 10.13 6 4S M 8.S 9.S 10.0 10.2 10.2 10.2 10.7 9.90 7F 9.2 9.S 9.6 10.0 9.S8 446 M 8.3 8.5 9.1 9.2 9.S 9.S 9.02 6F 7.3 8.8 9.1 9.1 9.2 8.70 s47 M 7.9 8.1 8.6 10.4 10.6 u.s 9.52 6F 7.7 9.1 9.9 10.6 9.33 4 48 M 7.4 7.7 7.9 8.1 7.78 4F 7.0 7.3 7.5 7.6 7.3S 4

LAC950-03/06


INOIVIDUAL ANlMAL IlA1A SUPPLEMENT

APPENDIX 9

JlAM NtMBER

PUP SEX 0 ppn

BODYWEIGHTS (g) BY LITTER 'IO DAY 29 POST P.IIRTIM - FlA PUPS


FEMALES CNT. MEAN CNT.

wr.

GROUP SlM1ARY MEAN 9 .19 98 8.88 111

S.D. 1.59 0

COUNT 21 1.69

22

0 ("') .....,....... -o ....... ""' 0

"" .....,

""' ...... ""'

~

"-<.........."t:l.......,.0\0.....

.,.....<.n

LI\C950-03/06

PERCfiT..OROETHYLENE: MULTIGENERATION lNHAl.ATION STUDY IN THE RAT

INDIVIOOAL ANlMAL DATA SUPPLEl1ENT

APPENDIX 9

BODYWEIGHTS (gJ BY LITI'ER TO Jl.\Y 29 POST PART!M - F1A PUPS MALES E!MALESDAM PUP INDIVIDUAL WEIGHTS Jl.\Y NO: 11 MEAN CNT. MEAN CNT.Nll1llER SEX 0 ppn wr. wr.

25 M 14.5 14.6 14.55 2F 10.0 12.6 13.3 14.5 14.8 13.04 5 26 M 18.6 18.8 19.8 19.9 20.9 19.60 5F 18.4 18.5 18.7 19.0 18.65 4 28 M 18.5 19.9 20.1 19.50 3F 15.7 16.4 17.7 17.8 18.0 18.1 17.28 6 30 M 25.2 26.4 25.80 2F 25.2 25.20 1 31 M 14.4 15.7 15.05 2F 13.0 13.00 1 32 M 15.7 16.2 16.5 16.8 16.30 4F 15.4 15.4 16.1 16.8 17.0 18.1 16.47 6 33 M 13.9 14.7 16.0 16.7 17.1 17.1 15.92 6F 13.1 15.1 16.0 16.3 16.7 17.3 15.75 6 34 M 21.5 22.2 21.85 '2F 19.1 19.8 20.1 20.2 20.4 20.7 20.8 20.16 7

35 M 18.4 18.5 18.6 18.50 3F 15.1 16.1 17.6 18.1 18.2 18.3 18.4 18.7 19.4 17.77 9 36 M 14.9 16.4 17.1 17.3 17.5 17.8 17.8 16.97 7F 14.4 15.4 15.6 16.4 16.5 18.0 16.05 6 37 M 16.1 16.3 17.1 17.2 17.4 17.6 16.95 6F 16.4 16.7 16.7 16.8 16.9 17.2 17.2 16.84 7

LAC950-03/06

PERCHLOROET!M..ENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANIMAL DATA. SUPPLEMENT

APPENDlX 9

BODYWEIGHTS (g) BY LI'!TER TO DAY 29 POST PARTtM - FlA PUPS MI\LES FEMALES

DAM PUP INDIVIDUAL WEIGHTS DAY NO: 11 MEAN em. MEAN em. NT.MBER 5E){ 0 PJlll wr. wr.

38 M 16.2 16.2 16.5 16.9 17.5 17.7 16.83 6 F 15.2 15.4 15.6 16.5 16.8 15.90 5

39 M 15.5 16.8 16.15 2 F 13.0 13.0 13.8 14.8 14.8 15.5 15.5 15.6 16.0 14.67 9

40 F 19.4 23.9 24.2 22.50 3

41 M 17.0 17.3 18.3 17.53 3 F 15.6 16.4 16.5 16.7 17.3 17.6 17.7 17.8 16.95 8

42 M 16.2 16.7 17.0 17.1 17.6 18.0 19.6 17.46 7 F 16.2 16.4 16.6 17.3 17.5 16.80 5

43 M 17.8 19.0 19.3 19.6 20.0 20.3 20.4 20.5 21.1 19.78 9 F 18.1 18.10 1

44 M 23.5 24.0 24.4 23.97 3 F 20.8 20.8 21.3 22.1 22.2 23.3 21.75 6

·46 M 16.8 17.7 17.9 18.1 19.2 20.2 18.32 6 F 15.2 17.8 18.0 18.8 19.0 17.76 5

47 M 15.6 15.9 16.7 19.5 19.7 20.9 18.05 6 F 13.9 17.0 17.7 20.2 17.20 4

----------------------GROUP stM!ARY MEAN 18.37 84

17.59 104 S.D. 2.91 0

2.99 0 COUNT 19

20

----------------------

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~-------~

LAC950-03/06

PERCHLOROETHYLENE: MIJLTIGENERATION INHALl\TION STUDY lli THE RAT

lliOIVIIJUAL ANIMAL DATA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (gJ BY LITI'ER TO DAY 29 POST PARTIM - FlA PUPS

llliM Nl.MBER

PUP SEX 0 ppn

INDIVIDUAL WEIGHTS DAY 00: 16 MALES MEliN wr.

F.EMliLES CNT. MEliN em.

wr.

25 M F

24.8 19.3

26.2 22.3 23.8 24.6 26.5

25.50 2 23.30 5

26 M F

28.3 27.1

28.4 27.2

28.5 27.6

29.1 29.4 28.3

28.74 5 27.55 4

28 M F

25.1 23.0

26.9 23.5

28.3 24.0 24.3 24.6 25.2

26.77 3 24.10 6

30 M F

36.3 38.4

38.2 37.25 2 38.40 1

31 M F

24.0 23.2

25.8 24.90 2 23.20 1

32 M F

24.5 24.2

24.7 24.2

25.1 25.8

25.7 26.1 26.3 26.6

25.00 4 25.53 6

33 M F

22.4 20.8

23.1 22.8

24.6 23.7

24.7 23.9

24.9 24.7

25.2 26.0

24.15 6 23.65 6

34 M F

29.0 28.1

30.7 28.5 28.9 29.0 29.6 30.4 31.0

29.85 2 29.36 7

35 M F

26.5 23.7

27.4 24.1

27.8 26.0 26.4 26.9 27.1 27.4 27.4 29.2

27.23 3 26.47 9

36 M F

20.6 18.8

21.8 21.4

22.8 21.6

23.0 21.7

23.3 22.6

23.8 23.4

23.9 22.74 7 21.58 6

37 M F

22.8 22.9

23.2 24.0

23.4 24.2

24.5 24.5

24.5 24.6

24.9 24.8 25.1

23.88 6 24.30 7

"-i r.._ "0.._..,. 0

""....,

..,.

.........,

LAC950-03/06

PERCBLORDETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 9

BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTtM - F1A PUPS MALES FEMALES

DAM PUP INDIVIDUAL WEIGHTS DAY NO: 16 MEAN CNT. MEAN CNT. NU1BER SEX 0 ppn wr. wr.

38 M 23.5 24.0 24.0 24.4 24.8 25.3 24.33 6 F 21.4 21.9 22.1 23.5 24.1 22.60 5

39 M 24.0 24.0 24.00 2 F 19.5 21.1 21.3 22.2 23.3 23.5 23.6 24.4 24.6 22.61 9

40 F 29.3 34.4 34.4 32.70 3

41 M 26.0 26.4 26.5 26.30 3 F 24.0 24.0 24.6 25.5 25.9 26.0 26.3 26.3 25.33 8

42 M 24.3 25.0 25.3 25.4 25.8 25.9 28.2 25.70 7 F 25.0 25.1 25.3 25.3 25.7 25.28 5

43 M 25.6 27.7 28.2 28.3 28.7 28.8 28.9 29.1 30.0 28.37 9 F 26.1 26.10 1

44 M 34.9 35.1 35.6 35.20 3 F 31.0 31.8 31.9 32.7 33.0 34.6 32.50 6

45 M 24.4 26.4 26.6 26.7 27.1 27.9 28.6 26.81 7 F 24.9 25.0 25.4 26.0 25.33 4

46 M 25.2 25.9 26.6 27.0 27.5 27.7 26.65 6 F 22.0 25.4 25.7 26.0 27.4 25.30 5

47 M 22.8 24.0 25.3 27.9 27.9 29.7 26.27 6 F 21.2 25.1 25.3 28.5 25.03 4

48 M 24.5 25.4 25.4 26.6 25.48 4 F 23.2 24.4 25.7 26.3 24.90 4

(") -I r......., ...... .;> 0 \0....,

.;>.... ())

r,

-----·--·--

LAC>.v-03/06

PERCHLOROEI'HYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANJMAL DATA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (g) BY LITTER TO !lAY 29 POST PARTIM - FJA PUPS MALES DAM PUP Fll!/ILESINDIVIDUAL WEIGHTS !lAY NO: 16 NU1BER MEt\N CNT, MEt\N SEX CNT.0 ppn wr. wr.

GROUP SlM1ARY MEt\N 26. 91 95 26.14 112

S.D. 3.56 0 3.95 0

COUNT 21 22

",...-......,-I

-...""'0....,""

""'.....""

LAC950-03/06

PERCHLORDETHYLENE: MIJLTIGENERATION lNHAI.ATION STUDY IN THE RA1'

INDIVIJXfAL ANlMAL DATA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS {g) BY LITTER TO DKf 29 POST PJ\RTIM - FlA PUPS

J:W1 NlMBER

PUP SEX 0 ppn

INDIVIDUAL WEIGHTS DKf 00: 22 MALES MEAN wr.

FE11\LES CNT. MEAN CNT.

wr.

25 M F

38.2 32.2

40.3 35.0 37.9 38.4 40.3

39.25 2 36.76 5

26 M F

45.3 42.7

45.3 43.6

46.1 44.1

47.2 44.3

47.3 46.24 •~ 43.68 4

28 M F

39.9 37.2

41.1 37.2

41.7 38.5 38.7 40.2 40.6

40.90 3 38.73 6

30 M F

60.2 62.3

60.6 60.40 2 62.30 1

31 M F

39.8 39.2

42.9 41.35 2 39.20 1

32 M F

38.3 37.1

38.5 38.2

38.9 38.3

39.3 38.7 39.5 39.6

38.75 4 38.57 6

33 M F

34.5 33.7

35.9 34.8

37.1 36.3

37.6 36.4

38.1 36.4

39.2 40.0

37.07 6 36.27 6

34 M F

47.4 42.0

47.8 43.5 43.6 44.1 44.4 44.5 45.5

47.60 2 43.94 7

35 M F

41.3 36.4

43.3 36.6

43.7 40.4 41.4 42.3 42.3 42.6 43.0 43.1

42.77 3 40.90 9

36 M F

33.0 29.6

33.7 32.2

34.6 33.3

35.8 34.0

36.5 34.9

38.0 37.0

38.1 35.67 7 33.50 6

37 M F

35.5 38.2

36.2 39.0

36.6 39.0

38.1 39.1

39.8 39.2

40.6 39.3 39.4

37.80 6 39.03 7

(""') ..... r-..,-...,. 0 1.0 ......

..,. ""0

~,

('"')--1r -...'"0-... 0""'<0.....

N""'......

I.ACY.:>0-03/06


INDIVIIJUAL ANIMAL DATA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (g) BY LITTER TO DAY 29 POST PARTIM - FlA PUPS MALES Ill>11 FEMIILESPUP INDIVIDUAL WEIGHTS DAY NO: 22 MEAN CNT. MEAN NMlER SEX 0 CNT.ppn wr. wr.

38 M 35.4 35.7 35.9 36.5 38.5 39.5 36.92 F 32.0 6 32.5 34.6 36.1 36.1 34.26 540 F 49.4 56.1 56.6

54.03 341 M 39.4 40.8 41.5 40.57 F 36.2 3 36.5 37.2 37.4 38.0 39.5 40.0 40.3 38.14 842 M 35.9 37.3 37.5 37.6 37.9 38.8 40.3 37.90 7F 36.7 37.6 37.7 38.1 38.3 37.68 543 M 41.4 42.1 43.7 44.0 44.3 45.2 45.3 45.7 49.5 44.58 F 40.0 9

40.00 144 M 51.6 53.3 53.4 52.77 F 45.1 345.7 46.2 47.4 48.8 51.9 47.52 645 M 46.4 49.2 50.0 51.0 51.0 52.4 52.8 50.40 7 F 47.0 49.0 49.0 49.5 48.63 446 M 34.6 36.0 36.3 38.4 38.7 38.8 37.13 36.8 6F 37.9 38.1 38.2 38.9 37.98 547 M 36.1 37.9 41.3 42.4 45.4 46.9 41.67 F 32.7 40.1 641.8 44.1 39.68 448 M 37.7 37.8 38.7 40.8 38.75 F 37.3 4 37.4 38.6 38.8

38.03 4

LAC950-03/06

PERCHLORDE'I'llYLENE: M!JLTIGENERATION IN!W..ATION STUDY JN THE RAT

INDIVIWAL ANIMAL DATA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (g) BY LITI'ER TO TWf 29 POST PARTIM - F1A l'UPS MI\LES FEMALES

JlAl1 PllP INDIVIDUAL WEIGHTS TWf NO: 22 MEAN CNT. MEAN CNT. NlMlER SEX 0 Jllill wr. wr.

GROUP SlM1ARY MEAN 42. 42 93 41.37 103

S.D. 6.32 0 6.85 0

COUNT 20 21

("")_, r .........., ........

""'0 \0 ......

""' N N

~

LAC950-03/06

PERCHLORDETHYLENE: MULTIGENERATION INHAlATION STUDY lli THE RAT


APPENDIX 9

Ili\M NU1BER

PUP SEX 0 P!Jll

BODYWEIGHTS (gi BY LITTER TO Ili\Y 29 POST PARTIM - F1A PUPS

INDIVIDUAL WEIGHTS Ili\Y NO: 23 MALES MEAN wr.

m1ALES CNT. MEAN CNT.

wr.

39 M F

40.4 29.0 34.4 34.5 36.3 37.8 38.3 38.3 38.7 39.8 40.9

40.40 1 36.80 10

GROUP 5tM1ARY MEAN 40. 40

S.D. 0.00

COUNT 1

1 36.80 10

0 0.00 0

1

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""" N w

- --

LAC950-03/06

PERCHLOROET!!YLENE: MULTIGENERATION INHAlATION STUDY lli THE RAT

INDIVIOOAL ANIMAL DATA S!JPPLEMENT

APPENDIX 9

BODYWEIGHTS (g) BY LITTER TO lli\Y 29 POST PARTIM - F1A PUPS JlAM

Nll1llER PUP SEX 0 PJlll

INDIVIDUAL WEIGHTS lli\Y NO: 29 MALES MF1IN wr.

ID!ALES 00. MF1IN oo.

wr.

25 M F

72.4 62.1

77.6 66.5 70.7 71.2 73.0

75.00 2 68.70 5

26 M F

84.2 76.1

84.2 79.2

85.9 80.0

86.3 86.6 80.7

85.44 5 79.00 4

28 M F

77.7 69.4

78.7 71.6

82.1 72.8 74.2 74.3 76.8

79.50 3 73.18 6

30 M F

105.0 107.5 101.0 106.25 2

101.00 1 31 M

F 76.2 80.7 75.1

78.45 2 75.10 1

32 M F

74.4 76.4 71.1 74.2

77.8 74.5

78.1 78.4 78.6 78.9

76.68 4 75.95 6

33 M F

65.0 65.9 63.6 65.7

69.1 67.0

71.8 68.8

72.7 71.7

78.6 72.0

70.52 6 68.13 6

34 M F

88.5 91.0 75.3 78.8 79.1 79.8 80.3 80.5 80.7

89.75 2 79.21 7

35 M F

78.0 78.9 65.7 67.2

81.0 73.7 75.4 76.9 77.4 78.0 78.1 81.5

79.30 3 74.88 9

36 M F

65.0 65.2 58.1 62.3

68.1 64.6

69.9 64.8

70.5 65.4

74.3 68.9

74.3 69.61 7 64.02 6

37 M F

67.3 72.2 70.0 71.1

74.2 71.8

75.4 72.0

75.5 72.1

75.7 72.8 73.1

73.38 6 71.84 7

(") -i r ......., ...... .j:> 0

""....,

.j:> N .j:>

~·.

-- ---' ~- - --·---~-

LAC950-03/06

PERCHLORDETilYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIX1AL ANIMAL DATA SUPPLEMENT

APPENDJX 9

BODYWEIGHTS (g) BY LITIER TO DAY 29 POST PARTIM - FlA PUPS

Il!\M NU1BER

PUP SEX 0 ppn



wr.

38 M F

69.8 62.9

71.0 64.9

72.0 65.1

72.3 68.5

76.3 69.2

78.0 73.23 6 66.12 5

39 M F

71.5 54.0 60.3 61.2 62.8 64.3 65.8 66.2 66.3 68.6 69.9

71.50 1 63.94 10

40 F 85.1 94.3 96.1 91.83 3 41 M

F 75.3 67.1

76.5 69.0

79.9 70.7 71.2 71.6 75.3 77.6 78.1

77.23 3 72.58 8

42 M F

69.8 67.9

71.5 67.9

73.4 69.1

73.8 70.1

74.5 72.7

75.8 78.2 73.86 7 69.54 5

43 M F

73.8 71.0

74.4 76.3 76.9 77.5 79.5 80.9 82.2 88.2 78.86 9 71.00 1

44 M F

94.0 78.4

94.0 79.4

96.6 81.7 83.5 84.3 89.5

94.87 3 82.80 6

45 M F

74.9 71.9

77.3 74.0

77.5 74.8

79.2 76.4

80.4 83.2 84.3 79.54 7 74.28 4

46 M F

67.2 59.3

67.2 68.6

73.0 70.0

73.8 71.5

75.5 72.4

75.9 72.10 6 68.36 5

47 M F

73.4 63.5

75.2 74.7

78.1 79.3

81.2 81.5

87.8 88.0 80.62 6 74.75 4

48 M F

75.3 71.9

75.5 72.9

75.6 73.2

82.2 75.1

77.15 4 73.28 4

"-I r.._.,.._ ..,. 0 0.0 ......

..,. N (J1

LAC950-03/06

PERCHLOROE'l'HYLENE: MULTIGENERATION INHALATION STUDY JN THE RAT

INDIVIJXIAL ANlMAL DATA SUPPLEMENT

APPENDIX 9

BODYWEIGIITS (g) BY LITI'ER ro DAY 29 POST PARTIM - FlA PUPS

DAM Nl.MBER

PUP SEX 0 Jlllll


ID!ALES CNT. MEAN CNT.

wr.

GROUP SlM1ARY MEAN 79 .18 94 74.52 ill

S.D. 8.77 0 8.65 0

COUNT 21 22

(") -i,......., ........,. 0

""....,

..,. N 0'>

/-,

LAC950-03/06

PERCHLOROETHYLENE: MULTIGENERATION IN!W..ATION STUDY IN THE RAT

INDIVIDUAL AN1MAL DATA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (g) BY LITI'ER 'IO DAY 29 POST PARTtM - F1A PUPS

DAM NtMBER

PUP SEX 100 ppn

INDIVIDUAL WEIGHTS DAY 00: 1 MIILES MEAN wr.

Flli\LES 00. MEAN 00.

wr.

74 M F

5.3 5.6

5.9 6.0

6.1 6.0

6.2 6.0

6.3 6.1

6.4 6.2

6.6 6.6

6.11 7 6.07 7

76 M F

5.3 4.4

5.6 5.3

6.2 5.4 5.5 5.5 5.6 5.7 5.9

5.70 3 5.41 8

77 M F

6.8 5.9

7.2 7.4 7.5 7.23 4 5.90 1

78 M F

5.3 5.2

5.4 5.6

5.6 5.7

6.0 5.7

6.2 6.0

6.3 6.5 5.90 7 5.64 5

79 M F

5.0 5.4

5.0 5.4

5.4 5.5

5.5 5.6 5.7 5.9 5.9 5.9 6.1 6.1 5.65 11 5.43 3

81 M F

5.8 5.4

5.8 5.7

5.8 5.7

5.9 6.0

6.0 6.2

6.1 6.4 6.4 6.03 8 5.80 5

82 M F

4.8 5.6

5.9 5.6

5.9 5.7

5.9 5.7

6.2 5.8

6.4 5.8

6.5 6.1

5.94 7 5.76 7

83 M 5.8 5.8 5.9 6.0 6.0 6.1 6.2 6.4 6.6 6.09 9 84 M

F 5.8 5.1

5.9 5.4

6.1 5.8

6.3 6.4

6.4 6.4

6.5 6.6 6.7 6.29 8 5.82 5

85 M F

5.9 5.8

6.0 5.9

6.3 6.0

6.3 6.0

6.5 6.3

6.9 6.32 6 6.00 5

86 M F

5.5 4.7

5.6 5.6

5.7 5.6

5.8 5.7 5.7 6.0 6.0

5.65 4 5.61 7

87 M F

5.0 4.8

5.3 4.9

5.4 5.1

5.5 5.2

5.6 5.2

5.7 5.3

5.7 5.6

5.9 6.4 5.61 9 5.16 7

("") -i r......., ........, 0 <.0....,

.., N....,

LAC950-03/06

PERCHLOllDETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDlVliiUAL ANIMAL DATA SUPPLEMENT

APPENDIX 9

BODYI<EIGHTS (g) BY LITTER TO DAY 29 POST PARTIM - FJA PUPS MALES FEMALESJlAM PUP INDIVIDUAL WEIGHTS DAY NO: 1 I1EI\N CNT. I1EI\N CNT.NlMBER SEX 100 ppn wr. wr.

88 M 5.9 6.1 6.1 6.1 6.2 6.08 5F 5.6 5.7 5.9 5.9 6.1 6.3 5.92 6 89 M 5.5 5.5 5.8 5.8 6.0 6.1 6.4 5.87 7F 5.1 5.3 5.4 5.5 5.5 5.36 5 90 M 6.6 6.60 1F 6.3 6.5 6.40 2 91 M 5.7 5.8 6.0 6.2 6.4 6.02 5F 3.3 5.2 5.6 5.7 5.9 6.1 6.3 5.44 7 92 M 5.6 5.7 5.9 6.0 6.0 5.84 5F 5.7 5.70 1 93 M 5.7 6.0 6.2 6.3 6.4 6.6 6.6 6.26 7F 6.0 6.1 6.2 6.3 6.3 6.18 5 94 M 5.2 6.5 6.5 6.5 6.6 6.8 6.8 7.0 6.49 8 F 5.9 5.9 6.1 6.7 6.15 4 95 M 5.4 5.7 5.8 5.9 6.1 6.2 6.3 5.91 7F 5.5 5.6 6.0 6.1 5.80 4 96 M 5.9 6.2 6.05 2F 5.9 6.0 5.95 2

("')

r--... ..,-;

-... 0~

0.0 ...,

~N CXl

>~

U\C950-03/06

PERCHLOROETHYLENE: MULTIGENERATION INI!ALATION STUDY IN THE RAT

lNDlVIIJUAL AN.lMAL DATA SUPPLEMENT

APPENDIX 9

EODYWEIGHTS (g) BY LITIER TO DAY 29 POST PARTIM - F1A PUPS MALES FEMALES

JlliM PUP INDIVIDUAL WEIGHTS DAY NO: 1 MEAN CNT. MEAN CNT. NlMlER SEX 100 ppn WT. WT.

GROUP SU11ARY MEAN 6.08 130 5.78 96

S.D. 0.37 0 0.31 0

COUNT 21 20

n -i,.... -'"0 -""' 0

"' .....

""' N

"'

LI\C950-03/06

PERCHLOROETHYLENE: MlJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANlli\1 DATA SUPPLEMENT

APPENDJX 9

BODYWEIGHTS (g) BY LITIER ID DAY 29 POST PART!M - F1A PUPS MALES FEMIILES lW1 PUP INDIVIDUAL WEIGHTS DAY NO: 5 MEAN CNT. MEAN CNT. N!MBER SEX 100 P!lll wr. wr.

74 M 5.8 7.9 8.2 8.4 8.5 8.5 8.7 8.00 7 F 7.6 7.7 8.0 8.0 8.2 8.5 8.6 8.09 7 76 M 8.9 9.1 9.5 9.17 3 F 7.0 8.6 8.7 8.7 8.8 8.9 9.2 9.6 8.69 8 77 M 13.3 13.5 13.9 14.2 13.73 4 F 12.0 12.00 1 78 M 7.7 8.3 8.4 8.5 8.6 8.30 5 F 7.1 7.8 7.8 8.3 8.6 7.92 5 79 M 5.6 6.5 6.6 6.7 7.1 7.2 7.3 7.4 7.8 8.0 8.1 7.12 11 F 7.0 7.1 7.2 7.10 3 81 M 7.9 8.3 8.4 8.7 8.7 8.9 8.9 8.54 7 F 7.5 8.1 8.5 8.5 8.5 8.22 5 82 M 6.0 8.5 8.7 8.8 8.9 9.0 9.1 8.43 7 F 8.0 8.1 8.4 8.8 9.2 8.50 5 83 M 8.5 9.1 9.1 9.3 9.6 9.8 10.0 10.1 10.5 9.56 9 84 M 7.7 8.5 8.9 8.9 9.3 9.4 9.6 8.90 7 F 7.5 8.3 8.6 8.6 9.3 8.46 5 85 M 10.2 10.4 10.6 10.8 10.9 10.58 5 F 9.5 9.7 9.8 10.4 10.7 10.02 5 86 M 7.7 7.8 7.9 8.3 7.93 4 F 6.4 7.8 8.0 8.2 8.2 8.4 8.4 7.91 7 87 M 7.8 8.0 8.1 8.3 8.4 8.5 8.6 8.6 9.9 8.47 9

F 7.3 7.6 7.7 8.2 8.5 8.6 7.98 6

(") .... r........., .......... 0 u:> ......

... w 0

~

--- ---~- --+-----~

U,C950-03/06

PERCHLOROET!IYLENE: MlJLTIGENERATION INHALATION STUDY IN TEE RAT

INDIVIOOAL iiNlMI\L DATA SUPPLEMENT

APPENDIX 9

DAM NU1BER

PUP SEl( 100 ppn

BODYWEIGHTS (g) BY

INDIVIDUAL

LITI'ER 'IO !lAY 29 FOST

WEIGHTS

PARTl.M - F1A PUPS

!lAY NO: 5 MALES MEAN wr.

FEMALES CNT. MEAN

wr. CNT.

88 M F

9.2 8.6

9.3 9.0

9.4 9.2

9.7 9.9 9.4 9.5 9.7

9.50 5 9.23 6

89 M F

8.4 8.0

8.7 8.6

8.9 8.7

9.1 8.9

9.2 9.0

9.2 10.0 9.07 7 8.64 5

90 M F

9.8 9.8

9.80 1 9.80 1

92 M F

9.3 8.6

9.7 9.8 9.60 3 8.60 1

93 M F

9.0 9.2

9.2 9.7

9.3 9.8

9.5 9.7 9.8 9.9 10.0 9.55 8 9.57 3

94 M F

7.4 8.3

8.6 8.5

9.3 9.4

9.4 9.6

9.5 9.7 9.8 10.1 9.23 8 8.95 4

95 M F

6.5 6.8

7.0 6.8

7.3 7.5

7.3 8.3

7.6 7.6 8.2 7.36 7 7.35 4

96 M F

8.2 8.5

9.3 8.8

8.75 2 8.65 2

----------------------GROUP ST.M1ARY MEAN

S.D.

COUNT

9.08 119

1.38 0

20

8.72

1.10

19

83

0

----------------------

(") .... r-...,-.. ""'0 1.0....,

""' w ....

LAC950-03/06

PERCHLORDETI!YLENE: MULTIGENERATION INHALATION STUDY IN TilE RAT

INDIVIIXIAL ANlMAL DATA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTIM - FJA PUPS

JlliM NlMBER

PUP SEX 100 ppn



wr.

74 M F

11.5 14.5

15.1 14.7

15.8 15.2

15.9 15.6

16.4 15.7

16.6 16.4

17.0 16.5

15.47 7 15.51 7

76 M F

16.2 12.7

16.3 15.3

17.3 15.6 16.0 16.3 16.4 16.5 17.0

16.60 3 15.73 8

77 M F

25.4 25.3

26.6 26.6 27.0 26.40 4 25.30 1

78 M F

17.0 15.5

17.1 16.0

17.2 16.0

18.2 17.2

18.2 17.7

17.54 5 16.48 5

79 M F

10.9 13.7

13.2 14.2

13.6 16.0

13.6 14.4 14.9 15.3 15.7 15.9 16.2 16.6 14.57 11 14.63 3

81 M F

15.8 14.8

15.9 16.1

17.5 17.0

17.6 17.1

17.7 18.1

18.0 19.0 17.36 7 16.62 5

82 M F

14.3 17.2

18.2 17.2

18.2 18.1

18.6 19.0

18.6 19.4

19.3 19.7 18.13 7 18.18 5

83 M 16.2 16.3 17.0 17.4 17.9 18.1 18.2 18.4 20.2 17.74 9 84 M

F 15.3 15.1

15.8 16.8

16.9 16.9

17.4 17.3

18.1 17.6

18.1 18.3 17.13 7 16.74 5

85 M F

17.0 16.5

17.8 17.4

18.5 17.4

18.5 17.7

18.6 17.8

19.0 18.23 6 17.36 5

86 M F

15.5 14.4

16.2 15.9

16.6 16.3

17.0 16.5 16.5 16.9 17.6

16.33 4 16.30 7

87 M F

15.2 13.5

15.4 15.1

15.8 15.7

16.7 15.9

16.9 17.6

17.3 18.6

17.5 17.7 18.0 16.72 9 16.07 6

"-i r...... "0 ........,. 0 1.0 .....

..,. w N

~-

LAC950-03/06


INDIVIIJUAL .AN.IMIIL DATA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (g) BY LITIER TO DAY 29 POST PARTIM - FlA PUPS

!lAM Nl.MBER

PUP SEX 100 ppn

INDIVIDUAL WEIGHTS DAY NJ: 11 MALES MEAN WT.

:m1ALES CNT. MEAN CNT.

WT.

88 M F

18.2 17.2

18.4 18.0

18.6 18.2

18.6 18.8

18.7 19.2 19.5

18.50 5 18.48 6

89 M F

15.0 15.9

15.1 16.1

15.6 16.2

16.1 16.4

16.5 16.7

16.5 16.9 15.96 7 16.26 5

90 M F

16.6 17.2

16.60 1 17.20 1

91 M F

15.5 15.2

15.6 16.1

16.5 16.2

17.1 16.8

17.4 16.8 16.8

16.42 5 16.32 6

92 M F

20.8 18.6

20.8 21.1 20.90 3 18.60 1

93 M F

16.6 16.7

16.9 17.1

17.0 17.4

17.2 17.4 17.5 17.7 18.0 17.29 8 17.07 3

94 M F

14.1 16.5

15.4 16.8

17.5 17.4

17.7 18.2

17.7 17.8 18.1 19.2 17.19 8 17.23 4

95 M F

14.1 13.9

15.0 14.4

15.2 14.5

15.4 16.0

16.2 16.3 16.5 15.53 7 14.70 4

96 M F

15.1 18.1

20.0 19.1

17.55 2 18.60 2

n -i,.... ...... '"0 ........,. 0 \0.._,

..,. w w

LAC950-03/06

PERCilLORDET!IYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INOIVIlXIAL ANlMAL DATA SllPPLEMENT

APPENDIX 9

DAM NIMBER

PUP SEX 100 ppn

BODYWEIGHTS (g) BY LITTER TO DAY 29 POST PARTt.M - FlA PUPS

INDIVIDUAL WEIGHTS DAY NO: 11 WILES MEAN wr.


wr.

GROUP SU11ARY MEAN

S.D.

COUNT

17.53 125

2.42 0

21

17.17

2.23

20

89

0 ('") -f r.._ .,.._ ""'0 \0 .....

""' w ""'

LI\C950-03/06

PERC!H.DROETHYLENE: MllLTIGENERATION INHAUITION STUDY IN THE RAT

INDIVIIXTI\L ANIMAL J:li\1A SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (g) BY LI'ITER TO DAY 29 POST PARTIM - F1A PUPS

DAM NtMlER

PUP SEX: 100 ppn


EEMI\LES CNT. MEAN CNT.

wr.

74 M F

19.0 21.7

23.3 22.7

24.0 23.3

24.1 23.9

24.3 23.9

25.0 24.3

25.6 24.8

23.61 7 23.51 7

76 M F

23.2 20.1

24.2 22.8

24.7 23.1 23.1 23.3 23.7 23.8 24.2

24.03 3 23.01 8

77 M F

34.6 34.8

35.7 36.7 36.8 35.95 4 34.80 1

78 M F

26.1 24.2

26.3 25.7

26.9 25.9

27.0 25.9

27.4 26.6

26.74 5 25.66 5

79 M F

15.6 19.2

18.4 19.4

18.7 20.6

18.8 19.5 19.6 19.8 21.0 21.1 21.6 21.9 19.64 11 19.73 3

81 M F

22.3 22.0

23.0 22.5

24.7 23.4

25.3 24.4

25.6 24.4

25.7 26.0 24.66 7 23.34 5

82 M F

21.3 24.3

25.3 24.6

25.9 24.8

26.1 25.7

26.1 26.9

26.3 26.6 25.37 ? 25.26 5

83 M 24.9 25.4 26.0 26.4 26.7 27.2 28.2 28.3 29.2 26.92 9

84 M F

23.2 23.6

23.9 24.5

25.7 24.6

25.8 25.5

25.9 26.5

26.4 27.2 25.44 7 24.94 5

86 M F

23.2 22.4

23.6 22.8

23.7 23.6

25.6 24.0 24.6 24.6 26.1

24.03 4 24.01 7

87 M F

21.4 17.4

21.7 20.1

21.8 20.8

22.5 21.9

22.6 21.9

23.0 23.5

23.1 24.1 24.3 22.72 9 20.93 6

88 M F

26.1 25.0

26.5 25.5

26.6 26.2

26.9 26.2

27.0 26.7 26.9

26.62 5 26.08 6

"-! r....... -o ....... """0

"' ....,

"""w U1

LAC950-03/06

PERCBLORDETHYLENE: MDLTIGENERATION IN!W.JITION STUDY IN TilE RAT

INDIVIOOAL AIID1AL DATA SUPPLEMENT

APPENDIX 9

JlAl1 NtMBER

PUP SEX 100 ppn

BODYWEIGHTS (g) BY LITI'ER TO !lAY 29 POST PARl'tM - F1A PUPS

INDIVIDUAL WEIGHTS !lAY NO: 16 MALES MEliN wr.

FEMALES CNT. MEliN CNT.

wr.

89 M F

22.3 21.8

22.8 22.7

23.2 23.3

24.0 24.4 24.6 24.8 23.6 24.1

23.73 7 23.10 5

90 M F

24.1 27.6 24.10 1

27.60 1 91 M

F 22.9 22.4

23.3 23.1

23.3 24.1

25.1 25.8 24.2 24.8 25.0

24.08 5 23.93 6

92 M F

32.5 31.1

32.9 33.6 33.00 3 31.10 1

93 M F

23.7 23.8

23.8 24.0

24.5 24.1

24.7 24.9 25.0 25.4 25.9 24.74 8 23.97 3

94 M F

21.9 23.9

24.1 24.8

24.4 25.4

24.6 25.8 25.8 26.3 27.9 25.5

25.10 8 24.90 4

95 M F

21.8 20.9

22.8 22.0

22.9 22.1

23.3 24.2 24.4 24.5 24.2

23.41 7 22.30 4

96 M F

28.4 23.4

28.7 26.8 28.55 2

25.10 2

----------------------GROUP SlM1ARY MEliN

S.D.

COUNT

25.62 119

3.57 0

20

24.91

3.41

19

84

0

----------------------

('")....., ' ...... """-.1» 0

""......

.1» w

""

LAC950-03/06

PERCHLOROE'IHYLENE: MULTIGENERATION INHAI.ATION STUDY lN THE RAT

JNDIVIDUAL ANIMAL D.'\TA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (gJ BY LI'ITER TO D!\Y 29 POST PARTtM - FlA PUPS M!\LES FEMALES

DliM PUP INDIVIDUAL WEIGHTS D!\Y 00: 17 ME!\N CNT. ME!\N CNT. NlMBER SEX 100 P!lll wr. wr.

89 M 23.4 24.3 24.4 24.9 25.6 25.9 25.9 24.91 7 F 22.9 24.0 24.9 25.0 25.1 24.38 5

91 M 23.7 24.1 24.5 25.8 26.6 24.94 5 F 23.1 24.2 24.5 24.7 25.7 25.8 24.67 6

GROUP SlM1ARY ME!\N 24.93 12 24.52 11

S.D. 0.02 0 0.20 0

COUNT 2 2

("') -;..-..._ '"C..._ ""' 0 <0....,

""' w....,

(""')

.......r-l

.,........,.0....,""

.,.wCD

LAC950-03/06

PERCHLORDET!ll'LENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL ANn1AL DATA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (g) BY LITI'ER 1'0 Jl.\Y 29 POST PARTIM - FlA PUPS MALES FEMALESDIIM PUP INDIVIDUAL WEIGHTS Jl.\Y NO: 22 ME8N CNT. ME8N CNT. NlMBER SEX 100 ppn wr. wr.

74 M 29.4 35.1 36.7 37.0 37.0 37.1 38.8 35.87 7F 31.8 34.1 35.5 35.6 35.8 35.9 38.3 35.29 7 76 M 37.4 38.9 39.3 38.53 3F 33.1 35.5 37.4 38.6 39.0 39.1 39.3 40.0 37.75 8 77 M 53.3 54.8 56.4 57.6 55.53 4F 52.5 52.50 1 78 M 42.6 43.3 44.4 44.4 46.1 44.16 5F 39.0 42.5 42.9 43.1 43.2 42.14 5 79 M 21.6 23.9 25.4 25.4 26.7 26.9 26.9 27.1 27.7 28.8 29.8 26.38 11F 25.0 25.4 27.5 25.97 3 81 M 35.6 37.7 38.1 38.8 39.8 40.0 40.2 38.60 7F 34.1 35.3 36.3 37.0 37.4 36.02 5 82 M 28.5 38.4 39.0 39.3 39.8 40.6 41.4 38.14 7F 36.6 36.7 37.2 39.0 41.5 38.20 5 83 M 37.5 39.4 40.2 41.0 42.1 42.1 42.2 44.1 45.2 41.53 9 84 M 34.1 34.2 36.9 37.1 38.5 38.8 39.6 37.03 7F 35.9 37.0 38.0 38.6 40.5 38.00 5 85 M 42.5 43.0 44.9 45.8 46.1 47.6 44.98 6F 39.4 40.7 41.1 42.4 43.2 41.36 5 86 M 34.9 36.4 37.6 38.8 36.93 4F 32.7 35.3 37.6 38.1 38.1 38.7 41.1 37.37 7 87 M 30.0 30.2 30.5 32.3 32.4 33.7 34.9 35.5 36.5 32.89 9F 24.0 29.9 30.8 33.2 33.3 37.1 31.38 6

LAC950-03/06

PEBCHLORDETIIYLENE: MIJLTIGENERATI:ON lNHALATION STUDY IN THE RAT

INDIVIlXJAL ANlMI\L DATA SUPPLEMENT

APPENDIX 9

BODYWEIG!ITS {gJ BY LITI'ER TO D!\Y 29 EQST PARTlM - FlA PUPS

DAM NlliBER

PUP SEX 100 ppn

INDIVIDUAL WEIGHTS D!\Y NO: 22 MALES MFAN wr.

FEMALES CNT. MFAN CNT.

wr.

88 M F

41.0 40.1

41.4 40.5

42.9 42.8

43.5 44.2 43.0 43.0 43.7

42.60 5 42.18 6

89 M F

34.9 33.2

35.7 34.8

36.4 35.7

36.8 37.5 38.5 39.5 36.3 36.7

37.04 7 35.34 5

90 M F

38.2 42.2 38.20 1

42.20 1 91 M

F 32.3 33.3

34.0 33.6

34.3 34.9

35.6 38.2 35.4 35.7 35.9

34.88 5 34.80 6

92 M F

50.1 47.2

51.0 51.1 50.73 3 47.20 1

93 M F

37.3 36.2

37.8 36.7

39.0 38.8

40.0 40.0 40.6 40.7 41.2 39.58 8 37.23 3

94 M F

31.3 35.4

36.1 37.3

36.4 37.4

36.4 37.4 38.3 38.5 42.0 37.5

37.05 8 36.90 4

95 M F

32.2 31.3

33.1 33.4

34.2 33.7

35.2 36.1 37.4 37.5 37.1

35.10 7 33.88 4

96 M F

39.1 40.9

42.8 41.7 40.95 2

41.30 2

(") -l

'-.. '"0-...., 0 \0 .....

.., w \0

LAC950-03/06


INDIIlii:UAL ANIW1L DATA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (g) BY LITTER TO DAY 29 POST PARTIM - FlA PUPS

ll'lM NlMlER

PUP SEX 100 PJlll

INDIVIDUAL WEIGHTS DAY ID: 22 MALES MEAN wr.


wr.

GROUP SlM1ARY MEAN 39.37 125 38.35 89

S.D. 6.12 0 5.64 0

COUNT 21 20

<"> -l ;........, .......... 0.,....,

... 2:;

~~

~LAC950-03/ 06

PERCH!.DROETilYLENE: MULTIGENERATION INilAI.ATION STUDY lli THE RAT

INDIVIDJAL ANIMAL DATA SUPPLEMENT

APPENDIX 9

JlAM NU1BER

PUP SEX 100

BODYWEIG!ITS (gi BY

INDIVIDUAL PJ;III

LITI'ER TO DAY 29

WEIGHTS

POST PAR11M - F1A PUPS

DAY NO: 29 MALES MEAN wr.

FEMALES CNT. MEAN

wr. CNT.

74 M F

62.4 62.2

68.1 65.3

68.7 69.5 70.3 71.4 71.7 65.5 68.2 68.8 69.8 73.5

68.87 7 67.61 7

76 M F

70.9 62.6

74.7 66.2

74.8 70.1 71.0 71.3 71.7 73.1 73.1

73.47 3 69.89 8

77 M F

97.5 93.6

97.6 99.1 105.6 99.95 4 93.60 1

78 M F

78.3 73.2

82.4 77.4

82.9 84.3 84.3 77.4 78.9 79.1

82.44 5 77.20 5

79 M F

42.8 49.2

48.0 51.1

50.7 54.5

51.7 52.8 53.1 53.8 55.0 56.0 56.7 57.6 52.56 ll 51.60 3

81 M F

67.5 64.1

70.7 65.2

73.1 65.7

73.4 66.3

73.7 68.6

74.4 75.6 72.63 7 65.98 5

82 M F

63.5 70.9

74.7 71.5

76.9 71.6

77.4 72.5

78.3 77.2

78.3 78.7 75.40 7 72.74 5

83 M 70.3 74.0 75.7 77.2 79.6 79.6 82.3 82.9 83.8 78.38 9

84 M F

63.5 66.4

66.1 68.4

67.5 70.9

70.5 71.4

70.6 74.7

71.0 71.8 68.71 7 70.36 5

85 M F

79.6 70.8

80.4 71.9

81.5 73.3

83.0 75.4

83.1 77.6

84.6 82.03 6 73.80 5

86 M F

68.9 62.4

72.0 67.5

74.0 68.3

77.9 70.0 70.9 73.9 75.8

73.20 4 69.83 7

87 M F

55.5 50.5

58.0 56.3

59.8 60.0

60.6 60.5

61.9 61.2

63.0 68.3

66.0 66.4 68.0 62.13 9 59.47 6

n -i .... ......., ........,. 0 <0....,

..,...,. .....

("')

.......r-1

'"0....... 0""'......""

"'""'""'

LI\C950-03/06


INDIVIDIJAL ANIMAL lliiTA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (g) BY LI'ITER TO DAY 29 POST PARTIM - FlA PUPS MALES mw.ESll'll1 PUP INDIVIDUAL WEIGHTS DAY N:l: 29 MEAN NU1BER CNT. MEAN CNT.SEX 100 ppn wr. wr.

88 M 76.7 79.2 80.2 80.8 81.3 79.64 5F 72.5 73.8 74.7 74.9 75.6 77.7 74.87 689 M 68.3 69.9 71.5 73.3 74.8 75.3 76.3 72.77 7F 65.0 68.1 70.0 70.9 73.9 69.58 590 M 66.9 66.90 1F 71.0 71.00 191 M 60.5 67.6 71.2 73.7 74.5 69.50 5F 65.4 67.9 68.7 69.0 70.1 70.6 68.62 692 M 91.0 92.4 93.0 92.13 3F 81.5

81.50 193 M 70.3 70.4 72.8 72.8 73.6 74.9 76.7 76.9 73.55 8F 69.2 70.6 70.9 70.23 394 M 60.1 67.3 68.5 69.5 69.6 72.7 73.2 80.9 70.23 BF 67.3 67.7 69.6 72.1 69.18 495 M 66.0 66.2 66.4 67.5 69.8 72.5 73.4 68.83 7F 62.0 62.6 62.9 71.8 64.83 496 M 75.2 84.6 79.90 2 F 78.5 79.4 78.95 2

LAC950-03/06

PERalLOROEI'HYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL AN.IMAL DATA SUPPLEMENT

APPENDIX 9

JlAM NLMBER

PUP SEX 100 ppn

BODYWEIGHTS (g) BY LI'ITER TO 00 29 POST P.ARTIM - F1A PUPS

INDIVIDUAL WEIGHTS 00 NO: 29 MIILES MEAN wr.

FE11\LES CNT. MEAN CNT.

wr.

GROUP Slll1ARY MEAN

S.D.

COUNT

74.44 125

9.98 0

21

71.04

8.42

20

89

0 n ..... r--o-.....,. 0 \0 ......

..,...,. w

LAC950-03/06

PERCBLORDETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 9

BODYWEIGHTS (g) BY LITTER '!0 DAY 29 FOST PARTtM - F1A PUPS MALES FEMALESDAM PUP INDIVIDUAL WEIGHTS DAY NO: 1 MEAN CNT. MEAN CNT.NCMBER SEX 300 ppn wr. wr.

122 M 5.2 5.2 5.3 5.3 5.3 5.4 5.6 5.33 7F 4.4 4.6 4.7 4.7 4.8 5.0 5.3 4.79 7 123 M 5.2 5.3 5.4 5.4 5.7 5.8 5.8 5.9 6.2 6.5 5.72 10F 4.5 5.2 5.5 6.4 5.40 4 124 M 5.3 5.3 5.4 5.6 5.6 5.9 5.52 6F 5.1 5.1 5.4 5.4 5.25 4125 M 5.9 6.0 6.1 6.6 6.9 6.9 6.40 6F 5.9 6.6 6.25 2126 M 6.2 6.8 6.8 7.6 6.85 4128 F 6.3 6.30 1 129 M 4.9 5.9 5.40 2F 6.0 6.2 6.3 6.17 3130 M 6.4 6.40 1F 6.6 7.3 6.95 2 131 M 5.9 5.9 6.3 6.4 6.6 6.22 5F 5.7 5.9 5.80 2 133 M 5.5 6.1 6.6 7.2 6.35 4F 5.8 5.9 5.9 5.9 6.0 6.2 5.95 6 134 M 4.9 5.4 5.7 5.9 6.2 5.62 5F 4.9 5.1 5.4 5.9 5.33 4 135 M 5.4 6.0 6.1 6.2 6.2 6.3 6.4 6.09 7F 5.3 5.30 1

(") ....r...... "0 ...... ..,.0 1.0 ....,

..,...,...,.

PERCHLORDETHYLENE: MIJLTIGENERATION INHAI.ATION STUDY IN THE RAT

OOI\IIlJUAL ANlMAL DATA SUPPLEMENT

APPENDIX 9

ll!IM NtMBER

PUP SEX 300 IJ!lll

BODYWEIGHTS (g) BY

INDIVIDUAL

LITI'ER TO DAY 29

WEIGHTS

POST PARTIM - F1A PUPS

DAY 00: 1 MALES MEAN wr.

FEMALES00. MEAN CNT.

wr.

136 M F

4.9 4.4

5.0 4.8

5.4 4.9

5.6 5.0 5.1 5.1 5.1 5.1

5.23 44.94 8

137 M F

5.5 5.0

5.8 5.0 5.1 5.1 5.2 5.3 5.4 5.4 5.4 5.6 5.6 5.8

5.65 25.33 12

138 M F

5.6 5.7

5.6 5.7

5.8 5.8

5.8 5.8 6.0 6.5 9.3 6.30 85.73 3

139 M F

5.7 4.9

5.7 5.0

5.7 5.2

5.8 5.2

5.9 5.4

6.05.4 5.4

5.80 6 5.21 7

141 M F

6.2 5.9

6.7 6.5 6.6 6.7 6.7 6.8 7.0

6.45 26.60 7

143 M F

5.6 5.1

5.6 5.2

5.6 5.2

5.6 5.4

5.7 5.5

5.8 5.8

5.9 6.1

5.69 75.47 7

144 M F

5.4 5.5

5.6 5.6

5.9 5.7

5.9 6.0

6.2 6.3 6.5 5.97 75.70 4

-----------------------GROUP SlM1!\RY MEAN

S.D.

COUNT

5.94

0.46

18

93

0 5.69

0.58

18

84

0

-----------------------

LAC950-03/06

n -i r-...... "'tJ ...... 0 ~

"' "

~ ~ U"l

l.AC950-03/06

PERCI:ILOROE'l'HYLENE: MULTIGENERATION INHALATION STUDY Til THE Rl\1

JNDIVIOOAL ANJMAL DATA SUPPLEMENT

.APPENDIX 9

BOIJYWEIGHTS (g) BY LITI'ER TO !lAY 29 POST PARTtM - F1A PUPS DAM

Nll1BER PUP SEX 300 ppn

INDIVIDUAL WEIGHTS !lAY NO: 5 MALES ME'AN wr.

FEMALES CNT. ME'AN CNT.

wr.

122 M F

6.1 6.6 5.7 6.0

6.7 6.6

6.8 6.7 6.9 7.1 7.3 7.6

6.55 4 6.74 8

123 M F

7.0 7.2 7.3 8.0

7.3 8.0

7.5 7.9 8.0 8.4 8.5 8.6 7.82 9 7.77 3

124 M F

7.9 8.0 6.9 7.6

8.3 7.9

8.5 8.5 8.9 8.9

8.35 6 7.83 4

125 M F

8.7 9.5 8.6 8.9

10.2 9.9

10.5 10.7 9.73 4

9.53 4 126 M 9.9 10.9 10.9 11.7 10.85 4 129 M

F 6.5 6.7 7.4 7.6 7.6

6.60 2 7.53 3

130 M F

9.0 9.9 11.0 9.00 1

10.45 2 131 M

F 7.0 7.1 6.1 6.8

7.1 7.2 7.6 7.20 5 6.45 2

133 M F

8.3 9.7 8.9 9.2

9.8 9.8

10.3 9.8 10.2 10.8

9.53 4 9.78 6

134 M F

6.1 6.6 6.8 6.9

7.6 7.8

8.4 9.2 7.9

7.58 5 7.35 4

135 M F

7.3 7.7 7.3

7.8 7.8 8.0 8.4 9.0 8.00 7 7.30 1

136 M F

7.2 7.7 6.2 6.9

7.9 7.0

7.9 7.2 7.3 7.4 7.5 7.6

7.68 4 7.14 8

("") -i r....... "0 .......... 0

"'......

...... "'

PEBCHLORDETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIru\L ANIMAL DATA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTT.M - F1A PUPS Mhl.ES FE1ALES111\M PUP INDIVIDUAL WEIGHTS DAYID: 5 MEliN CNT. MEliN CNT.NU1BER SElC 300 ppn wr. wr.

137 M 7.7 7.8 8.3 7.93 3F 7.4 7.4 7.5 7.6 7.6 7.7 7.7 7.8 7.9 7.9 7.65 10 138 M 8.1 8.2 8.2 8.5 8.6 8.8 9.0 8.49 7F 8.0 8.0 8.2 8.07 3139 M 7.9 8.0 8.3 8.4 8.7 8.8 8.35 6F 7.5 7.7 7.8 7.8 8.1 8.3 8.6 7.97 7 141 M 9.1 9.1 9.10 2F 8.9 9.4 9.6 9.6 9.8 10.0 10.2 9.64 7143 M 7.7 7.9 8.0 8.1 8.1 8.3 8.4 8.6 8.9 8.22 9F 7.5 7.7 7.8 7.8 8.2 7.80 5 144 M 6.6 7.1 7.4 7.8 7.9 8.1 7.48 6F 7.1 7.4 7.4 7.6 7.38 4

-----------------------G!1DUP SlM1ARY MEliN 8.25 88

8.02 81S.D. 1.09 0

1.14 0COUNT 18

17

-----------------------

LAC950-03/06

n_, .::::: ., ...... .,0 ...., "'

.,.,....,

LAC950-03/06

PERCHLOROETHYLENE: MDLTIGENERATION TilHALATION STUDY IN THE RAT

INOIVIOOAL ANlMAL DATA SUPPLEMENT

APPENDJX 9

BODYWEIG!ITS (g) BY LITI'ER TO DAY 29 POST PARTIM - F1A PUPS

DAM NlMlER

PUP SEX 300 ppn



wr.

122 M F

11.6 12.6

13.3 12.7

13.9 13.5

14.1 13.9 14.1 14.2 14.2 15.1

13.23 4 13.79 8

123 M F

13.4 14.4

13.6 15.1

13.8 15.4

14.4 15.4 16.0 16.0 16.3 16.6 15.06 9 14.97 3

124 M F

14.9 13.4

15.3 14.6

15.4 15.1

15.9 15.3

16.3 16.4 15.70 6 14.60 4

125 M F

20.8 19.7

21.1 20.8

21.8 21.1

22.9 23.0

21.65 4 21.15 4

126 M 20.7 21.0 21.3 21.9 21.23 4 129 M

F 11.3 15.2

13.6 15.9 16.6

12.45 2 15.90 3

130 M F

15.2 16.4 18.6 15.20 1

17.50 2 131 M

F 12.9 12.3

13.0 13.4

13.3 13.7 14.1 13.40 5 12.85 2

133 M F

15.5 17.1

18.2 17.2

19.2 17.7

19.3 18.3 18.6 19.6

18.05 4 18.08 6

134 M F

12.8 13.7

13.1 14.5

15.8 14.8

16.3 16.4

17.0 15.00 5 14.85 4

135 M F

14.1 14.5

14.2 15.7 15.9 16.2 16.2 16.8 15.59 7 14.50 1

136 M F

14.4 14.2

14.6 14.3

15.1 14.8

15.6 15.0 15.0 15.2 15.4 15.6

14.93 4 14.94 8

n -; r-., -.,. 0

"' "'

.,..,. CX>

~'

UC950-03/06

PERCHLOROETHYLENE: MULTIGENERATION INil8LliTION STUDY IN THE RAT

INDIVIDUAL 1\NlMAL DATA SUPPLl!l1ENT

APPENDIX 9

!lAM NtMlER

PUP SEX 300 ppn

EODYWEIGHTS (g) BY

INDIVIDUAL

LI'ITER TO DAY 29 POST

WEIGHTS

PARTIM - F1A PUPS

DAY NO: 11 Mi\IES MEAN wr.

.FEMALES CNT. MEAN CNT.

wr.

137 M F

14.1 12.5

14.6 13.7

14.8 13.9 14.1 14.3 14.3 14.4 14.5 14.5 14.6

14.50 3 14.08 10

138 M F

15.0 15.2

15.4 15.3

15.5 15.7

15.8 15.8 18.1 18.3 16.27 7 15.40 3

139 M F

14.3 13.9

15.0 14.7

15.1 15.0

15.1 15.4

16.2 16.0

16.6 16.1 16.9

15.38 6 15.43 7

143 M F

13.0 13.7

14.3 14.3

14.5 14.4

14.9 14.6

15.0 14.8

15.1 15.3 15.3 15.4 14.76 9 14.36 5

144 M F

14.7 15.1

14.8 15.2

15.3 15.3

15.6 15.5

16.6 17.3 15.72 6 15.28 4

----------------------GROUP SlM1ARY MEAN

S.D.

COUNT

15.77

2.47

17

86

0 15.48

1.98

16

74

0

-------------------

n_, ' ......., ...... """0

"" ......

""" """ ""

---

-------- ------ ----

U\C950-03/06

PEECBLORDETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIlXJAL ANlMAL DATA SlJPPLEMENT

APPENDIX 9

IlllM NU1BER

PUP SEX 300 ppn

BODYWEIGHTS (g) BY LITIER TO 00 29 POST P.ART!M - flA PUPS

INDIVIDUAL WEIGHTS 00 NO: 12 MALES MEAN wr.

FEM\LES CNT. MEAN CNT.

wr.

141 M F

18.5 19.1

19.0 19.3 19.3 19.4 19.8 19.8 20.2

18.75 2 19.56 7

----------------------GROUP SlM1iiRY MEAN

S.D.

COUNT

18.75

0.00

1

2

0 19.56

0.00

1

7

0

("""') ..... ,......., ......... 0

"" .....,

... U1 0

~-

lllC950-03/06

PERCHLOROETHYLENE: MIJLTIGENERATION INHALATION STUDY IN TilE RAT

INDIVIOOAL ANll1<\L DATA SUPPLEMENT

APPENDIX 9

!lAM NtMBER

PUP SEl{ 300 Pfil1

BODYWEIGHTS (g) BY

INDIVIDUAL

LITTER TO DAY 29 POST PIIRT

WEIGHTS

lM - E1A PUPS

ll'IY 00: 16 MALES MEliN wr.

FEMALES CNT. MEliN

wr. CNT.

122 M F

18.9 19.2

20.8 20.4

21.5 20.7

21.9 21.2 21.2 21.7 21.9 22.4

20.78 4 21.09 8

123 M F

20.4 21.1

20.9 21.5

21.1 22.1

21.9 21.9 22.7 22.8 23.1 23.2 22.00 9 21.57 3

124 M F

23.6 21.6

23.8 23.1

23.9 23.7

24.7 25.5

24.9 25.1 24.33 6 23.48 4

125 M F

29.9 29.3

30.0 29.5

30.7 29.5

32.3 31.9

30.73 4 30.05 4

126 M 32.0 32.2 32.7 34.1 32.75 4

129 M F

19.3 24.5

23.7 27.1 27.8

21.50 2 26.47 3

130 M F

23.2 24.7 27.5

23.20 1 26.10 2

131 M F

21.0 21.2

21.9 23.0

22.5 23.7 26.5 23.12 5 22.10 2

133 M F

22.8 25.5

27.6 25.7

27.8 26.3

28.2 27.5 27.8 28.7

26.60 4 26.92 6

134 M F

20.3 21.4

20.8 23.1

24.2 23.6

24.6 24.1

28.3 23.64 5 23.05 4

135 M F

21.2 21.9

22.7 23.9 24.4 24.6 24.6 26.0 23.91 7 21.90 1

136 M F

21.7 20.7

22.2 21.2

22.3 21.3

23.2 21.9 22.1 22.2 22.5 22.6

22.35 4 21.81 8

n ...... r....... "'0 .........,. 0

"' ....,

..,. <.n,_.

1AC950-03/06

PERC!ll.ORDETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL 1INIMAL ll'lTA SUPPLEMENT

APPENDIX 9

Ili\M Nl.MBER

PUP SEX 300 ppn

BODYWEIGHTS (g) BY

INDIVIDUAL

LITI'ER TO DNi 29 POST

WEIGHTS

PARTIM - F1A PUPS

DNi NO: 16 MALES MEAN wr.

Fl'MALES CNT. MEAN CNT.

wr.

137 M F

18.6 17.9

19.8 18.5

20.9 18.6 19.0 19.2 19.5 19.5 19.6 19.8 20.2

19.77 3 19.18 10

138 M F

23.0 22.6

23.1 23.1

23.4 24.6

23.5 24.1 26.5 28.1 24.53 7 23.43 3

139 M F

20.4 19.0

20.6 19.8

20.9 20.8

21.2 20.9

22.3 20.9

22.7 21.2 22.5

21.35 6 20.73 7

141 M F

24.9 25.7

26.1 26.2 26.4 26.6 26.9 27.1 27.1

25.50 2 26.57 7

143 M F

19.3 19.6

20.0 19.6

20.6 20.0

20.7 20.2

20.7 20.7

20.9 21.2 21.4 21.4 20.69 9 20.02 5

144 M F

20.2 22.5

22.7 22.6

22.9 22.6

24.6 23.3

24.8 26.0 23,53 6 22.75 4

----------------------GROUP stM1ARY MEAN

S.D.

COUNT

23.90

3.36

18

88

0 23.37

2.91

17

81

0

----------------------

('"') ...;........... -c .........,. 0

"" ......

..,. tTl N

~

LAC950-03/06

PERCHLORDETHYLENE: MIJLTIGENERATION INHAUITION STUDY IN THE RAT

INDIVIIJUAL ANIMAL DATA SUPPLEMENT

APPENDlX 9

IW1 NU1BER

PUP SEX 300 ppn

BODYWEIG!ITS (g) BY

INDIVIDUAL

LI'ITER TO DAY 29 POST PART

WEIGHTS

IM- FlA

DAY NO:

PUPS

22 MALES MEAN wr.

FJ;MALES CNT. MEAN

wr. CNT.

122 M F

29.1 28.6

31.1 29.5

33.0 31.7

33.7 33.0 33.4 33.8 34.5 34.9

31.73 4 32.43 8

123 M F

31.9 32.8

33.1 34.2

33.5 34.7

34.4 34.5 35.6 35.8 36.5 37.2 34.72 9 33.90 3

124 M F

36.4 35.2

36.5 36.3

37.0 36.5

37.2 38.5

37.2 38.7 37.17 6 36.63 4

125 M F

42.4 44.8

46.3 45.7

47.2 46.6

48.8 50.0

46.18 4 46.78 4

126 M 49.0 50.4 52.3 53.0 51.18 4

129 M F

30.4 37.4

35.4 39.1 40.1

32.90 2 38.87 3

130 M F

35.8 39.3 43.5

35.80 1 41.40 2

131 M F

34.6 35.1

35.6 38.5

36.5 37.2 40.0 36.78 5 36.80 2

133 M F

35.6 40.7

43.4 40.9

44.4 41.7

45.2 43.6 43.8 46.4

42.15 4 42.85 6

134 M F

29.5 32.0

31.2 33.3

33.4 33.6

38.3 38.3

42.6 35.00 5 34.30 4

135 M F

34.0 34.3

35.7 35.8 36.5 38.4 38.5 38.7 36.80 7 34.30 1

136 M F

31.5 32.6

32.7 32.6

34.5 33.0

35.8 33.0 34.1 34.4 34.8 35.0

33.63 4 33.69 8

n -i r-.. -o-...., 0 \0....,

.., (,)1 w

- -------

LAC950-03/06

PERCHLORDETHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDJAL ANThiAL DATA SUPPLEMENT

APPENDJX 9

BODYWEIGHTS (g) BY LITTER TO DP3 29 POST PARTIM - FJA PUPS DAM

NlMlER PUP SEX 300 ppn

INDIVIDUAL WEIGHTS DP3 ID: 22 MALES I1EAN wr.

FEM\LES CNT. MEAN CNT.

wr.

137 M F

30.1 26.8

31.9 29.7

32.6 29.9 30.1 30.2 30.2 30.3 31.3 32.1 32.2

31.53 3 30.28 10

138 M F

34.7 36.1

35.1 37.0

36.2 37.6

36.3 38.6 41.8 43.8 38.07 7 36.90 3

139 M F

29.2 29.8

31.2 30.8

31.5 30.9

31.6 31.6

31.8 31.8

33.6 32.5 33.1

31.48 6 31.50 7

141

143

M F

M F

42.7 41.6

26.1 27.0

42.6

26.4 27.1

42.6

27.0 28.9

43.2

28.4 29.4

43.3

28.5 30.4

44.3

28.7

44.3

28.9 29.6 29.6

42.70

28.13

1

9

43.13

28.56

, '

5 144 M

F 29.8 36.2

34.8 36.5

35.3 37.1

38.7 38.9

39.4 41.8 36.63 6 37.18 4

----------------------GROUP SlM1ARY I1EAN 36.81 87

S.D. 5.69 0 36.44 81

4.92 0 COUNT 18

17

----------------------

" -i r..._ "'0..._.,. 0

""....,

.,. 01.,.

~

-----~------

r-"-;

......."0..........0\0.....

...U1U1

LAC950-03/06

PERCHLOROE'IHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL ANlMAL lliiTA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (g) BY LITTER TO DIIY 29 POST PARTIM - E1A PUPS MALES FEMALESDI\M PUP INDIVIDUAL WEIGHTS DIIY NO: 29 MEAN em. MEAN em.NU1BER SEX 300 Jlllll wr. wr.

122 M 57.9 60.0 63.5 65.6 61.75 4F 55.9 56.6 57.9 59.5 61.8 61.9 63.7 65.2 60.31 8 123 M 62.2 63.1 63.3 64.8 66.4 68.5 69.0 69.2 69.4 66.21 9F 63.0 64.2 66.1 64.43 3124 M 73.3 74.5 75.3 75.6 75.8 76.1 75.10 6F 69.5 69.7 71.3 71.8 70.58 4 125 M 78.8 84.6 87.5 89.6 85.13 4F 81.5 82.0 82.5 90.4 84.10 4126 M 89.9 90.2 90.8 94.7 91.40 4 129 M 53.9 67.7 60.80 2F 68.4 69.6 78.0 72.00 3130 M 68.7 68.70 1F 69.6 77.2 73.40 2131 M 63.8 67.9 70.8 73.4 76.0 70.38 5F 62.5 69.3 65.90 2133 M 69.6 79.8 80.9 83.3 78.40 4F 71.7 73.2 75.5 77.2 78.4 79.0 75.83 6134 M 62.9 64.8 72.5 76.5 80.3 71.40 5F 63.0 65.2 70.1 76.7 68.75 4135 M 65.9 68.5 70.8 71.0 71.1 72.0 72.9 70.31 7F 65.4

65.40 1136 M 65.1 66.6 70.7 73.1 68.88 4F 61.6 63.2 63.3 63.3 65.0 65.7 67.3 67.4 64.60 8

LAC950-03/06

PERCBLORDETHYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIDUAL AN1MAL DATA stlPPLEMENT

APPENDIX 9

JlAM NlMlER

PUP SEX 300 ppn

BODYWEIGHTS (g) BY

INDIVIDUAL

LITIER TO DAY 29 POST PliRT

WEIGHTS

IM - FlA PUPS

DAY NO: 29 MALES MFAN wr.

F<MALES CNT. MFAN CNT.

wr.

137 M F

61.9 56.5

64.0 57.9

64.4 58.4 59.0 59.2 60.4 60.6 61.7 61.9 62.1

63.43 3 59.77 10

138 M F

69.7 66.0

69.8 66.6

69.9 67.4

71.1 72.1 75.5 79.4 72.50 7 66.67 3

139 M F

60.1 59.3

61.1 59.8

62.4 60.0

63.5 60.2

65.2 60.6

67.5 61.6 63.8

63.30 6 60.76 7

141 M F

80.0 73.0 76.6 77.1 77.9 78.7 80.5 80.8

80.00 1 77.80 7

143 M F

53.1 51.8

55.1 54.4

55.2 56.6

57.0 58.9

58.8 59.1

58.9 58.9 59.0 59.9 57.32 9 56.16 5

144 M F

64.0 70.6

67.6 71.7

70.6 71.7

74.0 72.1

78.0 81.4 72.60 6 71.53 4

-----------------------GROuP SlM1ARY MFAN

S.D.

COUNT

70.98

8.74

18

87

0 68.12

7.24

17

81

0

----------------------

(") ..... ,...._ ""0...._ ... 0

"".....

... t.T1 0'>

~.

LAC950-03/06

PERCHLOROETHYLENE: Ml.JLTIGENERATION INHALATION STUDY IN THE RAT

INDlVIIJUAL ANJM!IL DATA SUPPLEMENT

APPENDIX 9

DAM NU1BER

PUP SEX 1000 ppn

BODYWEIGHTS (gJ BY

INDIVIDUAL

LI'ITER TO DAY 29 POST

WEIGHTS

PARTtM - F1A PUPS

DAY NO: 1 MALES MEAN wr.

FEMALES 00. MEAN

wr. 00.

169 M F

5.9 4.9 5.0 5.2 5.2 5.4 5.4 5.4 5.5 5.5 5.8

5.90 1 5.33 10

170 M F

4.9 4.2

5.1 4.5

5.2 4.5

5.3 5.3 5.7 5.9 4.6 4.9 5.0 5.1

5.9 5.41 8 4.69 7

171 M F

5.5 4.5

5.5 4.7

6.1 5.2

6.5 5.3 5.5 5.5 5.6 5.6

5.90 4 5.24 8

172 F 5.8 5.9 6.0 6.3 6.00 4

173 M F

6.1 5.1

6.3 5.4

6.3 5.6 5.7 5.8 6.1

6.23 3 5.62 6

176 M F

5.4 4.8

5.7 5.1

6.1 5.1 5.2 5.2 5.3 5.9

5.73 3 5.23 7

177 M F

4.5 4.3

4.6 4.4

4.8 4.5

4.8 5.1 5.5 4.8 4.9 4.9 6.7

4.88 6 4.93 7

178 M F

4.9 4.8

5.0 4.9

5.3 4.9

5.7 6.2 5.0 5.0 5.1 5.7

5.42 5 5.06 7

179 M F

4.6 4.7

5.5 5.1

5.6 5.2

5.7 5.35 4 5.00 3

180 M F

5.2 5.0

5.4 5.5

5.6 5.5

5.6 5.7 6.1 6.2 5.6 5.7

6.2 5.75 8 5.46 5

181 M F

2.8 4.8

5.1 5.0

5.3 5.0

5.3 5.4 5.5 5.5 5.5 5.7 5.7 5.18 10 4.93 3

182 M F

5.3 4.8 5.3 5.3 5.3 5.4 5.5 5.8 6.6

5.30 1 5.50 8

("") ..... r-.., -..,. 0 <D.....,

..,. (Jl.....,

PERCHLOROETHYLENE: MDLTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIIlUAL ANM\L !lATA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (g) BY LI'l'l'ER TO DAY 29 POST PARTIM - F1A PUPS MALES FE1ALESJ:W1 PUP INDIVIDUAL WEIGHTS DAY NO: 1 MEAN CNT. MEAN NLMlER CNT.SEX 1000 PJlll WT. WT.

183 M 6.0 6.2 6.3 6.5 6.25 4F 5.6 6.1 6.1 5.93 3184 M 4.7 4.9 5.0 5.2 5.4 5.7 5.9 5.26 7F 4.8 5.0 5.1 5.2 5.03 4185 M 5.4 5.6 5.7 5.57 3F 5.4 5.4 5.4 5.40 3186 F 5.5 6.0 6.6 6.03 3187 M 4.0 4.0 4.6 4.6 4.7 4.8 4.9 5.0 5.0 5.2 5.3 5.5 5.8 4.88 13F 4.0 4.2 4.3 4.17 3188 M 5.7 5.9 6.0 7.0 6.15 4F 3.5 4.9 5.4 5.5 6.0 5.06 5189 M 5.1 5.8 5.9 5.9 6.1 6.1 6.4 5.90 7F 5.5 5.5 5.7 5.8 5.8 5.66 5191 M 4.3 4.5 4.8 5.1 5.3 5.4 5.4 5.5 5.04 8F 4.7 4.7 4.9 4.9 5.3 4.90 5192 M 5.3 5.30 1

-----------------------GROUP SlM-lARY MEAN 5.55 100

5.26 106S.D. 0.43 0

0.46 0OOUNT 19

20

-----------------------

("")--1r..._ "0..._..,.01.0......

..,.U"lco

LAC950-03/06

~.

LAC950-03/06

PERCHLOROETHYLENE: MLJLTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 9

BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PART!M - FlA PUPS MALES FEMALESDAM PUP INDIVIDUAL WEIGHTS DAY 00: 5 MEAN CNT. MEAN CNT.NU1BER SEX 1000 ppn wr. wr.

169 M 8.0 8.00 1F 6.5 6.6 7.1 7.1 7.3 7.6 7.6 7.6 8.1 7.28 9 170 M 8.5 8.5 9.1 9.4 9.4 9.9 10.2 10.8 9.48 8F 8.2 8.3 8.4 8.5 8.9 9.0 8.55 6 171 M 7.2 9.1 9.1 9.2 8.65 4 F 7.1 7.4 7.6 8.3 8.4 8.8 8.9 9.3 8.23 8172 F 8.3 9.1 9.2 9.2 8.95 4173 M 8.8 8.8 8.8 8.80 3F 6.9 7.1 7.9 8.3 8.4 9.1 7.95 6176 M 6.2 6.2 7.0 6.47 3F 3.4 6.4 6.4 6.8 5.75 4 177 M 6.1 6.3 6.7 7.0 7.2 7.4 6.78 6F 5.6 5.8 6.2 6.2 6.5 6.7 6.17 6 178 M 8.0 9.3 9.8 10.0 9.28 4F 8.1 8.1 8.3 8.6 8.9 9.0 9.0 8.57 7 179 M 7.7 8.0 8.5 8.7 8.23 4F 7.0 7.8 8.3 7.70 3 180 M 7.4 8.5 8.5 8.6 8.7 8.8 9.3 9.4 8.65 8F 7.7 7.9 8.3 8.4 8.5 8.16 5 181 M 7.9 8.0 8.5 8.5 8.5 8.7 8.9 9.2 9.3 8.61 9F 7.3 7.6 8.3 7. 73 3 182 M 6.8 6.80 1F 6.1 6.8 6.8 6.9 6.9 7.1 6.77 6

(""') __, .--c ~ --0 \0 .....,

~ <.n \0

--

LAC950-03/06

PERC!ll.DROEI'HYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL ANlM8L DATA SUPPLEMENT

APPENDIX 9

tw1 NU1BER

PUP SEX 1000 ppn

BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST P.ARTIM - FlA PUPS

INDIVIDUAL WEIGHTS DAY NO: 5 MALES ME';\N wr.

FEMALES CNT • MEl\N CNT.

wr. 183 M

F 5.5 6.5

6.2 6.6 7.2 6.38 4 6.50 1

184 M F

5.4 5.0

5.6 5.3

5.7 6.6 7.1 6.08 5 5.15 2

185 M F

7.4 7.1

7.4 7.2

7.9 7.9

7.57 3 7.40 3

186 F 5.9 6.9 7.1 6.63 3 187 M

F 5.7 6.0

6.1 6.2

6.3 6.2

6.3 6.6 6.6 6.6 6.9 6.9 7.0 7.0 7.1 7.3 6.65 13 6.13 3

188 M F

8.8 4.7

9.1 7.7

9.5 8.8

9.6 8.9 9.0

9.25 4 7.82 5

189 M F

6.4 7.3

7.6 7.5

7.8 7.6

8.2 8.2 8.6 8.9 7.8 8.1

7.96 7 7.66 5

191 M F

5.9 5.2

5.9 5.9

6.0 6.9

6.4 6.5 6.8 7.6 7.8 8.0 7.0

6.77 9 6.25 4

----------------------GROUP 5tM1ARY ME';\N

S.D.

COUNT

7.80

1.13

18

96

0 7.27

1.05

20

93

0

----------------------

("') -;

' ....... "0 .........,. 0 \0....,

..,. en 0

LAC950-03/06

PERCHLO!lDETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVllJUAL .ANJMIIL DATA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (g) BY LI'ITER TO DAY 29 POST PARTtM - F1A PUPS

Dl\11 NU1BER

PUP SEX 1000 Pflll

INDIVIDUAL WEIGHTS DAY 00: 11 MALES MEAN WI.

EEMALES CNT. MEAN CNT.

WI.

169 M F

16.0 12.2 13.3 13.7 15.0 15.1 15.4 15.4 15.6 16.2

16.00 1 14.66 9

170 M F

10.5 14.1 11.7 12.4

14.1 13.0

14.6 13.6

14.7 13.8

15.2 13.8

15.7 16.4 14.41 8 13.05 6

171 M F

10.3 15.4 10.1 13.0

15.8 13.6

15.8 14.0 15.7 15.9 16.2 16.7

14.33 4 14.40 8

172 F 13.8 14.0 17.5 15.10 3 173 M

F 14.2 15.5 11.8 11.9

17.5 13.1 13.1 15.7 15.7

15.73 3 13.55 6

176 M F

11.1 11.5 10.3 12.5

15.1 14.5

12.57 3 12.43 3

177 M F

10.6 11.1 9.8 10.0

12.0 11.3

12.6 11.6

13.3 12.6

14.1 13.2

12.28 6 11.42 6

178 M F

15.6 16.3 14.7 15.6

17.1 16.0

17.4 16.3 16.4 16.4 17.0

16.60 4 16.06 7

179 M F

13.6 15.4 11.5 14.7

15.9 15.2

16.4 15.33 4 13.80 3

180 M F

11.8 13.0 11.8 12.5

13.3 13.5

14.0 13.8

14.1 14.1

14.7 14.7 14.7 13.79 8 13.14 5

181 M F

13.0 13.0 12.3 12.3

13.1 14.4

13.8 14.4 14.5 14.7 14.7 13.90 8 13.00 3

182 M F

10.0 9.8 10.0 10.4 10.4 11.1 12.6

10.00 1 10.72 6

n -1.-....... -o .........,. 0 <0.....,

..,. "" ....

PERCHLOROET!IYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANlMIIL DATA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTlM - F1A PUPS MALES FEMALESDllM PUP INDIVIDUAL WEIGHTS DAY NO: 11 MEAN CNT. MEAN CNT.NtMBER SEX 1000 P!lll wr. wr.

183 M 7.6 10.1 10.3 12.0 10.00 4F 10.6 10.60 1 184 M 10.5 10.7 11.7 14.3 11.80 4F 9.1 9.9 9.50 2 185 M 11.4 11.5 12.3 11.73 3F 11.9 12.0 13.5 12.47 3 187 M 9.7 10.1 10.5 10.7 11.1 11.2 11.3 11.4 11.5 11.5 11.7 12.7 13.1 11.27 13F 11.1 11.2 11.6 11.30 3 188 M 16.9 17.4 17.5 17.7 17.38 4F 14.4 16.7 18.1 18.1 16.83 4 189 M 10.8 13.0 13.1 13.2 13.3 13.5 13.9 12.97 7F 12.0 12.2 12.8 13.1 13.2 12.66 5191 M 8.0 8.1 8.4 8.5 8.9 9.9 10.4 10.4 9.08 8 F 8.7 9.5 9.8 9.33 3

-----------------------GROUP stM1ARY MEAN 13.29 93

12.84 86S.D. 2.40 0

2.06 0OOUNT 18

19

LAC950-03/06

('")

.......r-<

"0 ....... 0 .1:>

....,0.0

.1:>en I'.>

~

LAC950-03/06

PERCHLORDE'IHYLENE: MULTIGENERATION INHALATION STUDY lli TilE RAT

OOIVIIJUAL AN.IMAL DATA SUPPLEMENT

APPENDIX 9

BODYWEIG!ITS (g) BY LITI'ER TO DAY 29 POST PART!M - FlA PUPS

11<\M NU18ER

PUP SEX 1000 Jli:Ill


FEMALES CNT. MEAN 00.

wr.

169 M F

21.6 18.8 20.1 20.9 21.4 22.0 22.2 23.2 23.7 24.1

21.60 1 21.82 9

170 M F

13.4 16.4

19.5 16.8

19.9 17.8

19.9 18.8

20.9 19.3

21.0 19.7

21.3 22.4 19.79 8 18.13 6

171 M F

16.2 14.6

22.0 20.0

23.1 21.2

23.7 21.2 22.5 22.7 24.1 24.2

21.25 4 21.31 8

172 F 21.2 22.5 25.0 22.90 3 173 M

F 20.6 17.1

23.1 17.3

24.3 19.0 19.0 23.1 23.8

22.67 3 19.88 6

176 M F

19.5 19.1

20.5 21.0

24.6 24.0

21.53 3 21.37 3

177 M F

16.3 13.7

16.9 15.6

17.5 15.8

18.1 16.0

18.9 18.4

19.5 19.1

17.87 6 16.43 6

178 M F

22.6 21.0

23.7 22.8

25.0 23.4

25.7 23.5 23.5 23.9 25.1

24.25 4 23.31 7

179 M F

20.1 17.9

22.8 21.4

23.1 21.8

23.9 22.48 4 20.37 3

180 M F

17.9 17.3

18.3 18.2

18.8 18.4

19.1 19.1

19.3 19.9

20.1 20.2 20.2 19.24 8 18.58 5

181 M F

17.6 16.6

18.3 18.1

18.9 19.7

19.4 19.4 20.7 21.2 19.36 7 18.13 3

182 M F

17.1 15.9 15.9 16.2 17.1 18.2 19.6

17.10 1 17.15 6

"--i r..._ -o..._ ..,. 0

""....,

..,. 0> w

I.AC950-03/06

PERCHLORDEI'HYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIIJUAL ANlMAL Il!\TA SUPPLEMENT

APPENDIX 9

BODYWEIGHTS (g) BY LI'ITER TO DP3 29 POST PARTlM - FlA PUPS

DI>.M NtMlER

PUP SEX 1000 Jllill

INDIVIDUAL WEIGHTS DP3 NO: 16 MALES MEAN wr.


wr.

183 M F

15.0 16.3

16.7 16.7 16.13 3 16.30 1

184 M F

14.7 13.8

16.4 15.8

19.0 19.9 23.6 18.72 5 14.80 2

185 M F

15.3 19.9

17.0 19.9

18.7 21.1

17.00 3 20.30 3

187 M F

13.7 14.9

14.0 16.3

15.6 18.5

15.6 15.7 15.8 16.3 16.4 16.8 16.8 17.7 17.7 18.7 16.22 13 16.57 3

189 M F

16.8 17.8

18.0 18.1

18.4 18.3

18.5 19.0

18.6 19.4

19.0 19.0 18.33 7 18.52 5

191 M F

12.2 13.5

12.5 14.5

13.2 14.7

13.6 13.8 13.9 15.4 15.8 16.2 14.07 9 14.23 3

GROUP SlM1!\RY MEAN 19.27 89 18.90 82

S.D. 2..75 0 2.68 0

COUNT 17 18

(") -i.--.....,-....., 0

""......

.., "'..,

L8C950-03/06

PERCHLOROEI'HYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIXJAL ANlMAL DATA SUPPLEMENT

APPENDIX 9

DAM NtMlER

PUP SEX 1000 ppn

BODYWEIGHTS (g) BY

INDIVIDUAL

LITl'ER TO J1tiY 29 POST P

WEIGHTS

ARTIM - FlA PUPS

J1tiY NO: 22 MALES MEI\N wr.

FEW.LES CNT. MEI\N

wr. CNT.

169 M F

36.7 29.8 31.3 33.7 34.7 35.0 36.0 36.3 38.8 39.1

36.70 1 34.97 9

170 M F

31.7 25.1

32.0 25.8

32.3 28.5

32.8 29.5

34.5 29.8

34.5 30.2

36.5 33.47 7 28.15 6

171 M F

24.2 25.3

35.4 31.0

37.2 32.6

37.7 33.6 35.5 36.6 37.8 38.3

33.63 4 33.84 8

172 F 35.5 37.8 43.3 38.87 3

173 M F

34.6 26.4

37.4 28.4

37.9 31.5 32.0 36.7 38.7

36.63 3 32.28 6

176 M F

31.5 31.1

34.7 34.2

40.7 38.8

35.63 3 34.70 3

177 M F

25.7 21.8

26.9 24.0

27.7 25.4

27.7 26.3

29.2 28.9

31.1 29.5

28.05 6 25.98 6

178 M F

37.1 33.7

37.3 36.7

40.3 37.1

41.5 37.3 37.6 37.9 39.3

39.05 4 37.09 7

179 M F

33.2 30.4

33.8 33.4

34.1 34.9

35.6 34.18 4 32.90 3

180 M F

23.1 25.7

26.5 25.9

29.5 30.1

30.0 31.6

30.4 32.5

31.7 32.3 33.3 29.60 8 29.16 5

181 M F

29.6 27.6

31.7 29.8

32.9 33.1

33.2 33.8 34.3 37.4 33.27 7 30.17 3

182 M F

26.8 26.8 27.5 28.6 31.0 31.4

26.80 1 29.06 5

('"') ......-....._ -o....._ .,. 0 \0 ......

.,. en U"1

LAC950-03/06


INDlVIIXJAL .ANIMAL llATA SUPPLEMENT

APPENDIX 9

Dl\M NtMlER

PUP SEX 1000 ppn

BODYWEIGHTS (g) BY

INDIVIDUAL

LI'ITER TO DAY 29

WEIGHTS

POST PART!.M - F1A PUPS

DAY NO: 22 M!ILES ME'AN wr.

m1I\LES CNT. ME'AN CNT.

wr.

183 M F

23.9 23.6

25.8 25.9 25.20 3 23.60 1

184 M F

23.9 21.4

25.4 25.2

27.9 30.9 35.1 28.64 5 23.30 2

185 M F

25.6 30.8

27.8 31.1

29.3 32.4

27.57 3 31.43 3

187 M F

21.9 22.8

23.5 25.7

24.0 27.1

24.8 24.9 25.7 26.1 26.1 26.3 26.6 26.7 28.1 28.5 25.63 13 25.20 3

188 M F

37.7 36.2

40.6 38.4

41.4 38.7

42.2 41.2

40.48 4 38.63 4

189 M F

26.1 26.6

27.5 27.0

28.1 28.6

29.1 29.7

29.5 30.3

30.1 30.3 28.67 7 28.44 5

191 M F

15.9 21.0

18.2 22.9

20.3 23.0

21.4 21.7 21.7 24.3 24.7 25.6 21.53 9 22.30 3

----------------------GROUP SlM1ARY ME'AN

S.D.

OOUNT

31.37 92 30.53 85

5.25 0 5.09 0

18 19

('"') -;,.... ...... "0 ......... 0 <.0 ......

... c:ro c:ro

____,

LAC950-03/06

PERCHLOROETHYLENE: MULTIGENERATION INHALATION SWDY lN THE RAT

INDlVIlXJAL ANIMAL DATA SUPPI.EM!NT

APPENDIX 9

DAM NlMlER

PUP SEK 1000 ppn

BODYWEIG!!TS (g) BY

INDIVIDUAL

LITTER TO DAY 29

WEIGHTS

POST PARTIM - F1A PUPS

DAY ID: 29 MALES MEAN WT.


WT.

183 M F

46.5 46.6

50.2 50.9 49.20 3 46.60 1

184 M F

48.7 43.3

50.9 49.3

57.9 58.6 67.7 56.76 5 46.30 2

185 M F

53.8 61.7

57.6 62.0

58.7 62.7

56.70 3 62.13 3

187 M F

44.0 45.3

47.1 48.9

47.7 50.3

48.1 48.3 49.7 49.9 50.1 51.8 53.2 53.3 54.7 56.8 50.36 13 48.17 3

188 M F

73.0 65.6

73.5 65.7

75.0 68.2

76.0 71.4

74.38 4 67.73 4

189 M F

49.8 50.2

50.9 50.5

53.0 52.1

54.6 54.9

55.4 55.2

56.1 56.2 53.71 7 52.58 5

191 M F

26.5 42.8

37.4 44.3

43.3 46.6

45.7 46.1 46.8 48.3 49.0 49.3 43.60 9 44.57 3

----------------------GROUP SlM1ARY MEAN

S.D.

COUNT

59.02 92 56.50 85

7.82 0 7.62 0

18 19

" -;....... "........,. 0 \0 .....

..,. c;, <X>

"~ "LAC950-03/06

PERCHLORDEl'Hl'LENE: MIJLTIGENEl1ATION INHAlATION STUDY IN THE RAT

INDI\ITIXJAL .ANlMAL DATA SUPPLEMENT

liPPENDIX 9

BODYWEIGHTS (g) BY LITI'ER TO ll!\Y 29 POST PARTIM - F1A PUPS

JliiM NU1BER

PUP SEX 1000 Jlllll

INDIVIDUAL WEIGHTS ll!\Y NJ: 29 MALES MEAN wr.

ID!ALES CNT. MEAN CNT.

wr.

169 M F

67.4 56.1 56.6 61.9 63.7 64.3 64.4 65.4 69.2 69.9

67.40 1 63.50 9

170 M F

57.2 45.6

58.1 48.8

58.2 51.7

58.8 52.8

60.0 53.2

63.4 55.4

64.3 60.00 7 51.25 6

171 M F

44.4 47.0

64.3 55.6

64.6 56.0

67.1 61.8 62.0 63.7 64.2 65.9

60.10 4 59.53 8

172 F 63.4 67.1 76.6 69.03 3

173 M F

61.6 50.6

65.3 54.6

66.9 57.7 58.2 64.0 66.5

64.60 3 58.60 6

176 M F

62.8 61.4

66.4 61.8

75.4 68.4

68.20 3 63.87 3

177 M F

50.7 45.1

51.3 47.1

52.8 47.2

52.8 49.7

55.1 51.3

56.7 55.0

53.23 6 49.23 6

178 M F

63.7 58.4

67.6 63.3

69.8 64.6

73.4 65.0 66.1 66.9 68.0

68.63 4 64.61 7

179 M F

62.0 57.2

62.4 62.3

63.8 65.1

67.5 63.93 4 61.53 3

180 M F

49.0 49.5

52.3 56.0

52.7 56.1

57.2 57.0

58.4 59.0

58.9 60.8 62.4 56.46 8 55.52 5

181 M F

54.1 49.6

57.0 53.3

57.8 56.4

59.6 60.3 60.6 67.1 59.50 7 53.10 3

182 M F

55.6 49.9 54.8 56.3 58.5 58.6

55.60 1 55.62 5

(""')_, r..._ -o..._..,. 0

"' ......

..,. C'> ......

PERCHLOROETHYLENE: MlJLTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 10

ORGAN WEIGHTS (g) - FO GENERATION

Organs were only weighed from animals surviving to scheduled termination.

Organs from animal numbers 78 and 138 were not weighed in error.

Key:

NO = number WT = weight RGHT = right

)

CTL/P/4097 - 469

U,C9~Cl-ll5\ll>

PERCHLORDEI'lll'LENE: !'[JLTIGENERATION Illlii\I.ATION STUDY IN THE RATINDIVIlJUAL ANIMAL DATA SUPP!..El>1ENTGROUP: 01 APPENDIX 10OOSE LEVEL: 0 wn

ORG\N WEIGHTS (g) - FO GENERATIONANIMAL BODYWEIGHTNO. TESTIS(g) TESTIS SEX: wr LEFT MALE1 I<I:rnEY 441.0 wr RGET I<I:rnEY1.680

wr LEFT LIVERz wr RGET 1.660 538.0 WEIGHT1.590 1.560 3 1.680 1.550 500.0 17.8901.610 1.980 4 1.570 2.000538.0 18.9901.7101.820 5 2.6501.840 506.0 19.9201.8001.636 6 1.790 1.671 504.0 16.7601.5241.742 7 1.5641.999 543.0 18.1901.8211.782 a 1.8291.752 524.0 21.9001.7771.590 9 1.8531.666 505.0 25.1791.7171.790 10 1.8241.870 482.0 22.8151.690 1.560 ll 1.6601.610 527.0 18.7601.610 2.610 12 1.6401.610 560.0 19.8301.700 1.700 13 1.9001.560 536.0 19.7501.8601.870 14 1.9101.830 486.0 24.1101.5201.730 15 1.6101.770 540.0 20.6301.480 1.780 16 1.7201.830 524.0 19.8301.840 1.600 17 1.9701.700 532.0 23.5401.850 1.750 19 1.8701.780 468.0 20.1001.8901.520 20 1.8101.600 484.0 22.2901.4201.560 1.630 1.630 17.9001.620 1.720 19.730

-{ ".-...... -c -.... ..,

0

"'....,

.., ...... 0

I.AC960-05/03

PERCHLOROE'l'HYLENE: !11LTIGENERATION lNHALATION STUDY IN T!lE RAT

!NDIVIOOAL 1INlMAL DATA SUPPLEMENT

APPENDIX 10 MALE

SEX:

ORGAN WEIGHTS (g) - FO GENERATION

ppn0 LIVEROOSE LEVEL:

KIDNEY WEIGHT

GROUP: 01 KIDNEY WT RGllT

TESTIS WT LEFTTESTIS WT RGHT 22.330

llOD'M:IGHT WT LEFT 1.680

1INlMAL (g) 1.430NO. 1.600 21.470

1.520 1.740562.0 1.610

21 1.680 19.8201.680 1.810

508.0 1.63022 1.520 21.840

1.600 1.760474.0 1.610

23 2.0201.960

SOLO 24

.., :::!

"0-......<3\0.....,

..,......,.....

LAC960-05/03

PERCHLOROETHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIXIAL ANlli\1 DATA SUPPLEMENT

APPENDIX 10

OBG\N WEIGHTS (g) - FO GENERATIONGROUP: 02 IXJSE LEVEL: 100 ppn SEX: MALE

ANlli\1 BODYWEIGHT 1ESTIS 1ESTIS KIDNEY KIDNEY LIVERNO. (g) wr LEFT wr RGHT wr LEFT wr RGHT WEIGHT

49 524.0 1.680 1.560 1.880 2.090 24.080

50 522.0 1.610 1.650 1.670 1.710 20.350

51 480.0 1.880 1.950 1.750 2.000 20.100

52 521.0 1.820 1.860 1.970 1.900 21.390

53 536.0 1.816 1.771 1.881 1.968 21.226

54 507.0 1.708 1.624 1.777 1.839 20.979

55 521.0 1.827 1.801 1.867 1.978 23.183

56 498.0 1.558 1.629 1.752 1.858 22.217

57 559.0 1.965 2.018 1.849 1.953 23.261

58 519.0 1.744 1.703 1.629 1.624 20.685

59 483.0 1.920 1.990 1.700 1.780 19.830

60 518.0 1.670 1.790 1.870 2.070 21.690

61 489.0 1.790 1.780 1.580 1.500 22.410

62 481.0 1.680 1.710 1.500 1.520 18.790

63 572.0 1.640 1.590 1.800 1.910 24.900

64 555.0 1.540 1.560 1.890 1.970 23.380

65 505.0 1.670 1.770 1.870 2.060 19.990

66 511.0 1.550 1.610 1.910 2.030 21.230

67 506.0 1.480 1.510 1.500 1.660 19.850

("") -I

-..r--o-.. -!'>0.....,

-!'>

""

....., N

LAC960-05/03

PERCHLOBDE'l'lffi..ENE: MDLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL ANlMAL DATA SUPPLEMENT

APPENDIX 10

ORGAN imG!ITS (g) - FO GENERATION GROUP: 02 OOSE LE\IEL: 100 Pfiil SEX: MALE

ANlMAL BODYWEIG!IT TESTIS TESTIS KitNEY KitNEY LIVER NO. (g) wr LEFI' wr RGHT wr LEFI' wr RGHT WEIG!IT

68 539.0 1.590 1.650 1.780 1.840 20.130

69 565.0 1.710 1.630 1.570 1.640 19.800

70 593.0 1.710 1. 740 1.850 1.930 22.860

71 485.0 1.560 1.520 1.630 1.670 18.090

72 503.0 1.760 1.790 1.370 1.490 19.170

n .....,....._ ..,..._..,. 0

"" ......

..,.

...... w

------------------- ----~

UIC960-05/03

PERCHLO!llJEI'HYLENE: MIJLTIGENEIJATION INHALATION STUDY IN THE RAT

INDIVIIX!AL ANIMAL DATA SUPPLEMENT

APPENDIX 10

ORGAN WEIGHTS (g) - FO GENEIJATION GROUP: 03 OOSE LEVEL: 300 P!lll SEX: MALE

ANIMAL BODYWEIGHT TESTIS TESTIS KIDNEY KIDNEY LIVER 00. (g) wr LEFT wr RG!IT wr LEFT wr RG!IT WEIGHT

97 518.0 1.720 1.750 1.810 1.930 21.880

98 586.0 1.780 1. 780 1.780 1.980 22.550

99 532.0 2.100 2.080 1.930 1.810 21.580

100 535.0 2.030 2.060 2.100 1.970 20.700

101 514.0 1. 790 1.770 1.630 1.650 19.210

102 514.0 1.750 1.660 1.800 1.820 18.680

103 535.0 1.919 2.015 1.841 1.967 23.100

104 492.0 1.725 1.597 1.699 1.857 19.097

105 530.0 1.960 1.883 2.181 2.307 28.885

106 499.0 1.827 1.760 1.717 1.783 20.645

107 494.0 1.902 1.993 1.700 1. 757 19.651

108 509.0 1.593 1.637 1.723 1.999 23.319

109 512.0 1. 730 1.700 1.600 1.750 20.970

110 523.0 1.760 1.790 1.700 1.980 21.070

111 627.0 2.010 2.010 2.280 2.480 28.870

112 506.0 1.570 1.560 1.640 1.740 22.070

113 588.0 l.790 1.770 2.150 2.270 22.710

114 530.0 1.790 1.780 1.800 1.900 21.680

115 506.0 1. 730 1.700 1.720 1.730 18.820

n --!.-..._.,..._.,. 0..,....,

.,.....,.,.

LAC960-05/03


INDI.VIDJAL AN1MAL JlliTA SUPPLEMENT

APPENDIX 10

ORGAN WEIGHTS (g) - FO GENERATION GROUP: 03 IXJSE LEVEL: 300 PJlll SEX: MALE

AN1MAL BODYWEIGHT TESTIS TESTIS lGINEY lGINEY LIVER NO. (g) wr LEFT wr RGHT wr LEFT wr RGHT WEIGHT

117 570.0 1.810 1.760 1.650 1.670 19.990

118 542.0 1.850 1.780 1.620 1.700 20.680

119 473.0 1.630 1.740 1.760 1.880 17.720

120 483.0 1.710 1.770 1.530 1.620 20.420 ("") -<,-... "'0-... -!'> 0 <0 .....

-!'> ..... U'l

,-,

LAL- _--05/03

PERCHLORDETHYLENE: MULTIG.ENERATION INHALATION STUDY IN TilE RAT

IND1VIIXU\L J\N1MAL DATA SUPPLEMENr

APPENDIX 10

ORGAN WEIGHTS (gi - FO GENERATIONGFOUP: 04 IXJSE I.EVEI:.: 1000 PJlll SEX: MALE

J\N1MAL BODYWEIGHT TESTIS TESTIS lCll:tlEY lCll:tlEY LIVERNO. (g) wr LEFT wr RGHT wr LEFT wr RGHT WEIGHT145 484.0 1.750 1. 720 2.070 2.020 19.070146 505.0 1.810 1.840 1.990 1.950 22.520 147 520.0 1.970 1.910 2.100 2.060 22.070 148 544.0 1.880 1.970 1.950 2.100 21.870149 510.0 1.870 1.840 1.960 2.080 20.370150 484.0 1.580 1.570 1.810 1.820 18.790151 509.0 1.862 1.890 1.870 1.799 25.060152 500.0 1.656 1.712 2.362 2.298 23.830 153 488.0 1.698 1.828 1.813 1. 798 21.758154 491.0 1.834 1.818 1.905 2.041 23.112155 556.0 1.960 1.950 1.990 2.030 22.040156 504.0 1.650 1.690 1.900 2.150 22.660157 533.0 1.740 1.770 1.870 2.190 22.580158 550.0 1.930 1.930 1.920 2.050 23.420159 583.0 1.870 1.770 2.130 1.940 22.910160 591.0 1.740 1.700 2.160 2.170 26.950161 577.0 1.740 1.900 2.200 2.160 25.510162 465.0 1.790 1.720 1.890 2.140 21.240163 436.0 1.500 1.490 1.760 1.610 19.110

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IAC960-05/03

PEllCliT.DROETHYLENE: MULTIGENERATION INHALATION STUDY lN THE RAT

lNDIVIIJUAL AN1MAL DATA SUPPLEMENT

APPENDIX 10

ORGAN WEIGHTS lg) - FO GENERATION GROUP: 04 IXlSE LEVEL: 1000 ppn SEX: MilLE

AN1MAL BODYWEIGHT '!ESTIS '!ESTIS KirnEY KirnEY LIVER NJ. (g) wr LEFT wr RGHT wr LEFT wr RGHT WEIGHT

164 542.0 1.620 1.560 2.110 2.410 26.960

165 535.0 1.660 1.680 1.870 1.980 23.480

166 542.0 1.800 1.780 2.050 2.170 25.790

167 442.0 1.620 1.600 1.530 1.730 19.110

168 530.0 1.710 1.830 2.000 2.010 23.420

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LAC960-05/03

PERC![,(JRQE'TifiLENE: MULTIGENERATION INHA!.Jd'ION STUDY IN THE RAT

INDI.VIlJUAL ANIMAL lliiTA SUPPLEMENT

APPENDIX 10

ORGAN WEIG!ITS (g) - FO GENERATIONGROUP: 01 IXlSE LEVEL: 0 ppn SEX: FEMALE

ANIMAL BODYWEIG!IT I<II:NE:Y' I<II:NE:Y' LIVER00. (g) wr LEFT wr RGHT WEIG!IT

25 290.0 1.240 4.UO 13.250

26 253.0 1.210 1.160 10.500

27 280.0 0.930 1.010 10.820

28 297.0 1.330 1.490 16.320

29 290.0 1.010 1.150 10.390

30 326.0 1.250 1.350 14.060

31 306.0 1.105 1.172 14.504

32 292.0 1.070 1.190 12.940

33 303.0 1.230 1.250 15.590

34 289.0 1.320 1.360 16.090

35 320.0 1.220 1.210 19.450

36 330.0 1.294 1.439 16.258

37 338.0 1.090 1.150 19.560

38 290.0 1.150 1.220 15.860

39 337.0 1.510 1.390 18.510

40 321.0 1.120 1.060 12.160

41 339.0 1.270 1.300 19.010

42 310.0 1.335 1.291 19.763

43 315.0 1.250 1.330 20.410

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LAC960-05/03

PERCHLOROETHYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT

INDIVJ:J:UAL ANJMAL DATA SUPPLEMENT

APPENDIX 10

ORGAN "WEIGHTS (g) - FO GENERATION GllDUP: 01 OOSE LEVEL: 0 ppn SEX: FEMALE

ANIMAL BODYWEIGHT K.IJ:NEY K.IJ:NEY LIVER oo. (g) wr LEFT wr RGHT "WEIGHT

44 309.0 1.207 1.257 17.219

45 299.0 1.209 1.288 17.978

46 330.0 1.140 1.330 19.390

47 290.0 1.160 1.280 14.900

48 292.0 1.490 1.830 15.350

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LAC960-05/03

PERCHLOROETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIlXJAL .AN.lMIIL Th\TA SUPPLEMENT

APPENDIX 10

ORGAN WEIGHTS (g) - FO GENERATION GROUP: 02 IXlSE LEVEL: 100 ppn SEX: FE1ALE

.AN.lMIIL BODYWEIGHT KIINEY KIINEY LIVER NO. (g) wr LEFr wr RGHT WEIGHT

74 335.0 1.290 1.440 19.950

75 296.0 1.220 1.170 12.810

76 276.0 1.180 1.270 12.620

77 312.0 1.140 1.300 16.770

79 285.0 1.320 1.280 18.200

80 285.0 1.030 1.140 11.760

81 298.0 1.160 1.250 13.810

82 298.0 1.290 1.370 19.480

83 270.0 1.080 1.190 14.520

84 316.0 1.460 1.500 15.070

85 291.0 1.200 1.190 16.510

86 292.0 1.290 1.290 14.220

87 325.0 1.500 1.440 23.770

88 290.0 1.200 1.290 14.390

89 329.0 1.300 1.330 17.220

90 290.0 1.110 1.180 13.540

91 303.0 1.230 1.270 17.730

92 333.0 1.287 1.379 14.779

93 276.0 1.210 1.250 15.910

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LAC960-05/03

PERCBLORDETHYLENE: MULTIGENERATION INHALATION STUDY IN TilE RAT


APPENDlX 10

ORGAN WEIGHTS (g) - FO GENERATION GROUP: 02 !XlSE LEVEL: 100 ppn SEX: IDlALE

ANlMAL BODYWEIGHT I<IImY I<IImY LIVER NO. (g) wr LEF'r wr RGHT WEIGHT

94 308.0 1.230 1.330 17.040

95 282.0 1.230 1.090 14.690

96 267.0 1.180 1.170 12.890

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LAC960-05/03

PERCHLOROETilYLENE: MI.JLTIGENERATION INHALATION STUDY IN TilE RAT

lNDIVIlXJAL AN1MI\L DATA SUPPLEMENT

APPENDIX 10

ORGAN WEIGIITS (g) - FO GENERATION GROUP: 03 OOSE LEVEL: 300 PJlil SEX: ID1i\LE

AN1MI\L BODYWEIGIIT I<l:OOEY I<l:OOEY LIVER NO. (g) wr LEFT wr RGHT WEIGIIT

121 269.0 1.040 1.210 11.240

122 334.0 1.260 1.360 18.750

123 336.0 1.300 1.300 19.410

124 313.0 1.220 1.310 16.610

125 341.0 1.340 1.390 18.130

126 313.0 1.310 1.450 13.690

127 300.0 1.080 1.180 13.790

128 295.0 1.050 1.060 11.750

129 305.0 1.150 1.290 13.150

130 292.0 1.150 1.170 12.730

131 342.0 1.400 1.430 19.330

132 302.0 1.300 1.290 12.880

133 349.0 1.260 1.260 17.440

134 297.0 1.180 1.200 13.310

135 296.0 1.240 1.260 13.720

136 304.0 1.290 1.280 14.600

137 295.0 1.100 1.260 16.340

139 290.0 1.150 1.290 14.010

140 286.0 1.210 1.320 13.020

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LAC960-05/03

PERCHLOBDEl'HYLENE: MULTIGENERATION lNHALATION STUDY IN TEE RAT

INDIVIDIAL ANIMAL DATA SUPPLEMENT

APPENDlX 10

ORGAN WEIGHTS (g) - FO GENERATION GROUP: 03 IXJSE LEVEL: 300 PJD1 SEX: FEMALE

ANIMAL BODYWEIGHT KirnEY KirnEY LIVER 00. (g) wr LEFT wr RGHT WEIGHT

141 294.0 1.197 1.232 13.478

142 302.0 1.ll0 1.260 ll.100

143 287.0 1.140 1.280 15.420

144 346.0 1.320 1.360 16.340 ("") -I r-... '"0-... """ 0 0.0 .....

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LAC960-05/03

PERCHLOROE'l'HYLENE: MIJLTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIOO!lL ANlMAL rnTA SUPPLEMENT

APPENDIX 10

ORGAN WEIGHTS (g) - FO GENERATIONGROUP: 04 DJSE LEVEL: 1000 ppn SEK: FEMALE

ANlMAL BODYWEIGHT KILl'lEY KILl'lEY LIVER00. (g) wr LEFT wr RGHT WEIGHT

169 302.0 1.330 1.370 16.520

170 368.0 1.375 1.488 19.554

171 360.0 1.280 1.470 21.660

172 298.0 1.200 1.230 14.780

173 312.0 1.210 1.300 15.870176 363.0 1.310 1.300 17.800

177 310.0 1.340 1.370 16.380 178 318.0 1.497 1.577 18.577

179 283.0 1.250 1.260 14.500

180 317.0 1.280 1.300 15.120

181 310.0 1.300 1.310 15.580

182 330.0 1.290 1.430 15.590

183 328.0 1.280 1.360 14.270 184 316.0 1.270 1.320 14.280 185 322.0 1.390 1.380 14.890 186 279.0 1.190 1.150 10.270

187 369.0 1.350 1.390 20.620

188 322.0 1.480 1.504 17.688

189 291.0 1.370 1.330 16.370

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LAC960-05/ 03

PERCHLORDETHYLENE: MDLTIGENERATION IN!!ALATION STUDY IN TilE RAT

INDIVIIXIAL AliDIAL !lATA SUPPLEMENT

APPENDIX 10

ORGAN "WEIG!ITS (g) - FO GENERATION GROUP: 04 IXJSE LEVEL: 1000 Jllll1 SEX: m!ALE

AliDIAL BODYWEIG!IT KIDlEY KIDlEY LIVER NO. (g) wr LEFl' wr RGHT "WEIG!IT

190 403.0 1.350 1.550 18.570

191 263.0 1.130 1.150 14.210

192 283.0 1.150 1.090 11.390

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PERCHLORDETilYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIXIAL .1\NIMAL DATA SUPPLEMENT

APPENDIX 10

ORGAN WEIGHTS (g) - FO GENERATIONGROUP: 01 OOSE LEVEL: 0 ppn SEX: MALE

-------------------------- C 0 MME NT S -------------------------- .1\NIMAL NO.

11 LEFr TESTIS SLIGHTLY ENLARGED/FIRM.

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LAC960-05/03

PERCHLORDETHYLENE: MDLTIGENERATION lliHAIATION STUDY IN THE RAT


l\PPENDIX 10

ORGAN WEIGHTS {g) - FO GENERATION GROUP: 04 OOSE lEVEL: 1000 PfDI SEX: MALE

-------------------------- C 0 MM EN T S ---------------------------ANlMAL NO.

167 LEFr KIL'NEY MIS-SHAPEN.

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PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY lli THE RAT

lliDIVIDlTAL ANIMAL DATA SUPPLEMENT

.APPENDIX 10

ORGAN WEIGHTS (g) - FO GROUP: GENERATION01 OOSE LEVEL: 0 ppn SEX: FEMALE

-------------------------- C 0 MM EN T S -------------------------- AN1MAL NO.

25 RIGHT KIJ:tiEY ABNORMAL.

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PERCHLOROETHYLENE: MULTIGENERATION IN!W.81'ION STUDY IN THE RAT

INDIVIDUAL ANIMAL DATA SlJPPLEl1ENT

APPENDIX 10

ORGAN WEIGHTS (g) - FO GENERATION GROUP: 03 lXJSE LEVEL: 300 Jlllil SEX: FEMALE

-------------------------- C 0 MME NT S -------------------------- ANIMAL NO.

123 JCJ::WEY WEIGHTS !DENTICLE. rouBLE CHECKED, AND CORRECT.

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APPENDIX 11

ORGAN WEIGHTS (g) - FlA PUPS

Key:

NO. = number TERM = termi na 1 bodyweightKIDB = kidney (both) LIV = liver TESB = testes (both} PUPID = pup identification

CTL/P/4097 - 490

I

PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RATINDIVI!JlTAL ANlMAL DATA SUPruMENTAPPENDIX 11

ORGAN WEIGHTS (g) - FJA PUPSMALESGROUP: 1 DJSE LEVEL: 0 PEM

PARENT rn1ALE 00. PUPID TERM KIDB LIV TESB

28 D 95.1 1.201 5.254 0.75530 c 108 1.343 6.040 0.93533 c 71.8 0.878 4.154 0.48936 c 83.2 0.949 4.441 0.62938 c 78.0 0.843 4.241 0.50142 E 79.3 1.074 4.246 0.66643 F 80.9 0.992 4.461 0.59244 G 94.0 1.092 4.727 0.68947 D 87.8 0.994 5.128 0.66748 E 82.2 0.952 4.760 0.59948 F 75.5 0.944 4.716 0.671n -I r-..."'0-....,. .....,"'0

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APPENDIX 11 ORGAN WEIGHTS {g) - F1A PUPS

MALES GROUP: 2 IXlSE LEVEL: 100 PFM

PARENT I'EMALE NO. PUPID TERM KIDB LIV TESB

77 c 106 1.225 5.493 0.833 81 E 74.4 0.929 3.853 0.564 83 B 83.8 0.910 3.816 0.600 84 E 70.5 0.920 3.450 0.558 86 E 68.9 0.802 3.995 0.459 93 E 72.8 0.844 4.173 0.575 94 c 80.9 0.964 4.845 0.550 95 c 67.5 0.814 3.644 0.500 96 D 84.6 0.961 4.799 0.582

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APPENDIX 11ORGAN WEIGHTS (g) - F.lA PUPS

MI\LESGROUP: 3 DJSE LEVEL: 300 PEM

PARENT ID1ALE 00. PUPID TERM KIDB LIV TESB

125 E 89.6 1.142 4.853 0.757125 F 84.6 1.034 4.475 0.646126 c 89.9 1.100 5.106 0.690134 D 62.9 0.804 3.425 0.393135 D 71.0 0.877 3.750 0.500135 E 72.9 0.884 3.962 0.496137 F 61.9 0.786 3.585 0.495139 E 63.5 0.841 3.652 0.488143 D 59.9 0.710 3.195 0.386144 G 81.4 0.876 4.362 0.642("'")....................r-., 0\0.....,

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PERCHLOROEI'l!YLENE: MDLTIGENERATION lli!IALATION STUDY IN THE RAT INDIVIDUIIL ANlMIIL DATA SllPPLEMENT

APPENDIX 11 ORGAN WEIGHTS (g) - FlA PUPS

MALES GROUP: 4 OOSE LEVEL: 1000 PEM

PARENT FEMALE NO. PUPID TERM KIDB LIV TESB

177 G 52.8 0.672 2.887 0.399 179 D 63.8 0.808 3.457 0.437 179 E 62.0 0.743 3.206 0.478 181 G 60.6 0.726 3.665 0.395 181 H 54.1 0.615 3.123 0.339 183 H 46.5 0.564 2.180 0.259 184 J 67.7 0.814 4.140 0.426 185 D 53.8 0.627 3.194 0.341 185 E 58.7 0.785 3.224 0.369 191 F 49.3 0.578 2.907 0.309

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PAPr.-- 3.8800.741 71.2 4.579 0.9Bl J 84.9 4.687F 1.015 25 e~.z ;1.700

2.6 c o.~o~28 74.JD ~~~~32 ~.~lo 79.1 E 34 q.~no.9n 40 B 85.1

1.086 S.bQSc 96.1 4·14971.5 0.819 ~.032 4.873

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INDIVIOOI\L 1\NTh!!<L 1::WrA SUPPIDlliNT

m'EiiDlX 11 'ORGt'J!, :wEJ:Gl!TS (g)' - F1A PUPS

m1ALES OOSE LEVEL: 100 PR1GROUP: 2

LIV TESBTERM KIDB PABENT ffi1ALE ID. PUPID

3:556 71.7 0.796 76 D 0.960 4.087G 71.0 76 0.811 3.132

79 E 55.7 3.961E 79.2 0.888 82 4.094 74.7 0.940 84 H

0.812 3.48886 D 67.5

0.844 3.71787 E 61.2

4.062H 68.3 0.838 87 3.870 77.7 0.849 88 c 4.026 70.6 0.834 93 H

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APPENDIX 11

FEMALES ORGAN i-IEIGHTS (g) - FJA PUPS

GROUP: 3 OOSE LEVEL: 300 PEM

PARENT FEMALE NO. PUPID TERM K!DB LIV 'IESB

123 H 66.1 0.866 4.279 129 E 68.4 1.020 4.195 134 136 137 139

G D E D

70.1 67.4 61.9 59.3

0.871 0.807 0.773 0.722

3.681 3.734 3.677 3.107

143 E 51.8 0.662 3.076 143 H 56.6 0.705 3.022 144 J 71.7 0.812 3.998

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ORGAN VlEIGHTS .. ( ) ·.; J!J.A PUPs··· g. '

~-;· 4 OOSE I..EVF;L: 1000 "PEM

PARENT FEMALE ~. -~IIT TERM KIDB LIV TESB

169 F 172 D 173 p:173 H 177 J,'1eo D·1~- I6Hlz J 189 c_

68.1 63.4 58;2 54;5 55:;6 56.1 54.8 49.9 50.2

0.849 3.840 0.820- 3<722,-.0•723· 3'd9d•0.667 2;ss3~;0.672- 2'S88·0.753 3:12o:. 0;671' 2.826::0,546 2.652 0.549 2.663

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