This informaon is only for business-to-business purposes, not for consumers www.winclove.com Number of scientific articles Measured on Pubmed Nov 2014 L. plantarum W1, the world’s second most researched probiotic strain 600 120 100 80 60 40 20 0 La-5 acidophilus Lp 299 plantarum NCFM acidophilus Bb-12 bifidobacterium L. plantarum W1 LGG rhamnosus Lactobacillus plantarum W1 The intestinal microbiota plays a key role in several physiological, metabolic and immunologic processes and when disrupted is associated with disease. L. plantarum W1 is identical to the very well-documented L. plantarum WCFS1. The strain has proven to be able to survive the gastrointestinal tract, strengthen the intestinal barrier function and balance the immune system. Since the strain is highly stress resistant, it is suitable for industrial applications. L. plantarum is a multi-applicable and extensively studied probiotic strain. Probiotic characteristics The potential in vitro and in vivo effects of L. plantarum W1 have been extensively studied. Favorable probiotic characteristics of W1 are: • QPS (Qualified Presumption of Safe) status • Fully known genome and of human origin 1 • Halal and allergen free • Able to handle the oxidative stress in the colon 2 • Good lactic acid and acetate producer 3 • Fast growing to high cell densities 4 • Able to adapt to a wide variety of environments and substrates 5 • Potential to lower high cholesterol levels 6,7,8 • Good ability to adhere to the intestinal wall 9 • Ability to produce several antimicrobial substances 10,11,12,13 • High survival capacity in the human gastrointestinal tract 14, 15 • Potential to enhance the intestinal integrity 16,17 • Enhances the defense against intracellular pathogens such as bacteria and viruses 18,19 • Reduces inflammatory conditions 20,21
Transcript
This information is only for business-to-business purposes, not for consumers
www.winclove.com
Num
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L. plantarum W1, the world’s second most researched probiotic strain
600
120
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80
60
40
20
0
La-5 acidophilus
Lp 299 plantarum
NCFM acidophilus
Bb-12 bifidobacterium
L. plantarum W1
LGG rhamnosus
Lactobacillus plantarum W1
The intestinal microbiota plays a key role in several physiological, metabolic and immunologic
processes and when disrupted is associated with disease. L. plantarum W1 is identical to the very
well-documented L. plantarum WCFS1. The strain has proven to be able to survive the
gastrointestinal tract, strengthen the intestinal barrier function and balance the immune system.
Since the strain is highly stress resistant, it is suitable for industrial applications. L. plantarum is a
multi-applicable and extensively studied probiotic strain.
Probiotic characteristics
The potential in vitro and in vivo effects of L. plantarum W1 have been
extensively studied. Favorable probiotic characteristics of W1 are:
• QPS (Qualified Presumption of Safe) status
• Fully known genome and of human origin1
• Halal and allergen free
• Able to handle the oxidative stress in the colon2
• Good lactic acid and acetate producer3
• Fast growing to high cell densities4
• Able to adapt to a wide variety of environments and substrates5
• Potential to lower high cholesterol levels6,7,8
• Good ability to adhere to the intestinal wall9
• Ability to produce several antimicrobial substances10,11,12,13
• High survival capacity in the human gastrointestinal tract14, 15
• Potential to enhance the intestinal integrity16,17
• Enhances the defense against intracellular pathogens such as bacteria
and viruses18,19
• Reduces inflammatory conditions20,21
References
1. Kleerebezem, M., Boekhorst, J., van Kranenburg, R., Molenaar, D., Kuipers, O. P., Leer, R., ... & Siezen, R. J. (2003). Complete genome sequence of Lactobacillus plantarum
WCFS1. Proceedings of the National Academy of Sciences, 100(4), 1990-1995.
2. Serrano, L. M., Molenaar, D., Wels, M., Teusink, B., Bron, P., de Vos, W., & Smid, E. (2007). Thioredoxin reductase is a key factor in the oxidative stress response of
Lactobacillus plantarum WCFS1. Microbial Cell Factories, 6(1), 29.
3. Lahtinen, S., Salminen, S., Von Wright, A., & Ouwehand, A. C. (Eds.). (2011).Lactic acid bacteria: microbiological and functional aspects. CRC Press.
4. Cohen, D., Renes, J., Bouwman, F. G., Zoetendal, E. G., Mariman, E., de Vos, W. M., & Vaughan, E. E. (2006). Proteomic analysis of log to stationary growth phase
Lactobacillus plantarum cells and a 2‐DE database.Proteomics, 6(24), 6485-6493.
5. Esteban-Torres, M., Reverón, I., Mancheño, J. M., de las Rivas, B., & Muñoz, R. (2013). Characterization of the first feruloyl esterase from Lactobacillus plantarum.
Applied and Environmental Microbiology.
6. Lambert, J. M., Bongers, R. S., de Vos, W. M., & Kleerebezem, M. (2008). Functional analysis of four bile salt hydrolase and penicillin acylase family members in
Lactobacillus plantarum WCFS1. Applied and environmental microbiology, 74(15), 4719-4726.
7. Lambert, J. M., Siezen, R. J., de Vos, W. M., & Kleerebezem, M. (2008). Improved annotation of conjugated bile acid hydrolase superfamily members in Gram-positive
bacteria. Microbiology, 154(8), 2492-2500.
8. Lambert, J. M., Weinbreck, F., & Kleerebezem, M. (2008). In Vitro Analysis of Protection of the Enzyme Bile Salt Hydrolase against Enteric Conditions by Whey
Protein− Gum Arabic Microencapsulation. Journal of agricultural and food chemistry, 56(18), 8360-8364.
9. Russo, P., López, P., Capozzi, V., de Palencia, P. F., Dueñas, M. T., Spano, G., & Fiocco, D. (2012). Beta-glucans improve growth, viability and colonization of probiotic
microorganisms. International journal of molecular sciences, 13(5), 6026-6039.
10. Sturme, M. H., Francke, C., Siezen, R. J., de Vos, W. M., & Kleerebezem, M. (2007). Making sense of quorum sensing in lactobacilli: a special focus on Lactobacillus
plantarum WCFS1. Microbiology, 153(12), 3939-3947.
11. Rolain, T., Bernard, E., Courtin, P., Bron, P. A., Kleerebezem, M., Chapot-Chartier, M. P., & Hols, P. (2012). Identification of key peptidoglycan hydrolases for morphogenesis,
autolysis, and peptidoglycan composition of Lactobacillus plantarum WCFS1. Microbial cell factories, 11(1), 137.
12. Van der Veen, S., & Abee, T. (2011). Mixed species biofilms of Listeria monocytogenes and Lactobacillus plantarum show enhanced resistance to benzalkonium chloride
and peracetic acid. International journal of food microbiology, 144(3), 421-431.
13. Hevia, A., Martínez, N., Ladero, V., Álvarez, M. A., Margolles, A., & Sánchez, B. (2013). An Extracellular Serine/Threonine-Rich Protein from Lactobacillus plantarum
NCIMB 8826 Is a Novel Aggregation-Promoting Factor with Affinity to Mucin. Applied and environmental microbiology, 79(19), 6059-6066.
14. van Bokhorst-van de Veen, H., van Swam, I., Wels, M., Bron, P. A., & Kleerebezem, M. (2012). Congruent strain specific intestinal persistence of Lactobacillus plantarum in
an intestine-mimicking in vitro system and in human volunteers. PloS one, 7(9), e44588.
15. Vesa, T., Pochart, P., & Marteau, P. (2000). Pharmacokinetics of Lactobacillus plantarum NCIMB 8826, Lactobacillus fermentum KLD, and Lactococcus lactis MG 1363 in
the human gastrointestinal tract. Alimentary Pharmacology and Therapeutics, 14(6), 823-828.
16. Karczewski, J., Troost, F. J., Konings, I., Dekker, J., Kleerebezem, M., Brummer, R. J. M., & Wells, J. M. (2010). Regulation of human epithelial tight junction proteins by
Lactobacillus plantarum in vivo and protective effects on the epithelial barrier. American Journal of Physiology-Gastrointestinal and Liver Physiology, 298(6), G851-G859.
17. Cario, E., Gerken, G., & Podolsky, D. K. (2004). Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C.Gastroenterology,
127(1), 224-238.
18. Dong, H., Rowland, I., & Yaqoob, P. (2012). Comparative effects of six probiotic strains on immune function in vitro. British Journal of Nutrition, 108(3), 459.
19. Ramshaw, I. A., & Ramsay, A. J. (2000). The prime-boost strategy: exciting prospects for improved vaccination. Immunology today, 21(4), 163-165.
20. Smelt, M. J., de Haan, B. J., Bron, P. A., van Swam, I., Meijerink, M., Wells, J. M., ... & de Vos, P. (2013). Probiotics Can Generate FoxP3 T-Cell Responses in the Small
Intestine and Simultaneously Inducing CD4 and CD8 T Cell Activation in the Large Intestine. PloS one, 8(7), e68952.
21. Smelt, M. J., de Haan, B. J., Bron, P. A., van Swam, I., Meijerink, M., Wells, J. M., ... & de Vos, P. (2013). The Impact of Lactobacillus plantarum WCFS1 Teichoic Acid
D-Alanylation on the Generation of Effector and Regulatory T-cells in Healthy.
