Lancet 2013; 382: 339

Lancet Diabetes Endocrinol 2014; 2: 801

whether an intensive lifestyle interventionaffects the development of nephropathyin people with type 2 diabetes

Cu

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ence

of

very

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(%

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JAMA 2002;288:2421

CMAJ 185, 949, 2013

Composite outcome: doubling of serum creatinine level and 50% decline in glomerular filtration rate, or end-stage kidney disease.

Diabetes Care 2016;39:694

Intensive: gliclazide based intensive glucose control regimen, aiming for an HbA1c level of 6.5%.

Circulation 2019;139:2022

hospitalization for: new-onset macroalbuminuria sustained doubling of serum creatinine or a 40% decline in estimated glomerular filtration rate, end-stage kidney disease, or death of renal cause.

Hazard ratio

Renal-specific composite outcome of end stage kidney disease, doubling of serum creatinine level, or renal death.

N Engl J Med 2019;380:2295

J Clin Endocrinol Metab 103: 4491, 2018

Am J Kidney Dis 71: 166; 2018

J Am Coll Cardiol 2019;74:1465

J Am Coll Cardiol 2019;74:1465

J Am Coll Cardiol 2019;74:1465

J Am Coll Cardiol 2019;74:1465

J Am Coll Cardiol 2019;74:1465

Atherosclerosis 220 (2012) 201

Cardiovascular mortality associated with normal (eGFR−) or impaired eGFR (eGFR+) and absence (P−) or presence of proteinuria (P+)

Atherosclerosis 220 (2012) 38

Lancet 2013; 382: 339

Lancet 2013; 382: 339

Lancet 2013; 382: 339