Launching Presention Painkil

8/12/2019 Launching Presention Painkil

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The pain management is always a problem

for a physician and the search for a safe andeffective option is still on..

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So, Veritas pharmaceuticals Ltd.

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Arthritis

Arthritis is a disorder that causes pain, stiffness andswelling in or around joints. Cartilage is a proteinsubstance that serves as a "cushion" between the bonesof the joints. Arthritis is caused by the breakdown and

eventual loss of the cartilage of one or more joints.

Causes

There are many causes of arthritis. Heredity plays a majorrole. Some of these includes bacterial and viralinfections, traumatic injuries etc.

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Osteoarthritis

There are many different types of arthritis. Themost common type is called Osteoarthritis.

Osteoarthritis causes excessive strain and the

wearing away of cartilage in the joints of thefoot.

Movement becomes very difficult and painful.

The pain and swelling worsens while standingor walking, and stiffness usually occurs afterperiods of rest.

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Rheumatoid arthritis

Another type of arthritis is Rheumatoid arthritis.

It can cause severe deformities of the joints with

associated fatigue of the entire body.

It can develop at any age and there is no known

cause for this condition.

Rheumatoid arthritis is the most crippling (severe

and disabling damage) form of the disease that canaffect people of all ages.

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Alkylosing Spondilitis

Ankylosing spondylitis is an inflammatorydisease that can cause some of the vertebrae inyour spine to fuse together.

This fusing makes the spine less flexible and canresult in a hunched-forward posture.

A severe case of ankylosing spondylitis canmake it impossible for you to lift your head highenough to see forward

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People are losing their most productive years of

adulthood due to RA, (age 20- 40).

1 % of world population affected by RA

Among those 50 % patients unable to perform their full-

time job (after 10 years of onset)

World wide 9.6 % of men and 18% women over 60 years

have Symptomatic Osteoarthritis.

Rheumatoid Arthritis (RA)

WHO says

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General Information

Product Profile

Brand Name : Painkil

Generic name : AceclofenacJustification : PainKillerTherapeutic Class : NSAIDsDosage form : Tablet(Film Coated)

Pack Size : 10 x 10sMRP : Tk. 400/ box

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Indication

Osteoarthritis Rheumatoid arthritis Ankylosing spondylitis

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Mechanism of Action

From the phospholipasesof cell membrane . Arachidonic acid

is released. This intermediate arachidonic acid is created

from phospholipase-A2. This arachidonic acid goes by the

cyclooxygenase pathway and produces prostaglandin,

thromboxaneand prostacyclin.

Painkil block the cyclooxygenase pathway and stoparachidonic acid to produce prostaglandin. It has more

selectivity in Cox-2 than Cox-1.

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http://en.wikipedia.org/wiki/Arachidonic_acidhttp://en.wikipedia.org/wiki/Phospholipase_A2http://en.wikipedia.org/wiki/Thromboxanehttp://en.wikipedia.org/wiki/Prostacyclinhttp://en.wikipedia.org/wiki/Arachidonic_acidhttp://en.wikipedia.org/wiki/Arachidonic_acidhttp://en.wikipedia.org/wiki/Arachidonic_acidhttp://en.wikipedia.org/wiki/Arachidonic_acidhttp://en.wikipedia.org/wiki/Arachidonic_acidhttp://en.wikipedia.org/wiki/Arachidonic_acidhttp://en.wikipedia.org/wiki/Prostacyclinhttp://en.wikipedia.org/wiki/Thromboxanehttp://en.wikipedia.org/wiki/Phospholipase_A2http://en.wikipedia.org/wiki/Phospholipase_A2http://en.wikipedia.org/wiki/Phospholipase_A2http://en.wikipedia.org/wiki/Phospholipase_A2http://en.wikipedia.org/wiki/Arachidonic_acidhttp://en.wikipedia.org/wiki/Arachidonic_acidhttp://en.wikipedia.org/wiki/Arachidonic_acid


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Mechanism of Action

Phospholipid(From Cell Membrane)

Arachidonic acid

Prostacyclin ThromboxaneProstaglandin

Pain PainPain

Phospholipase A2

Cyclooxygenase Painkil(-)

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Dosage and Administration

Adults: The recommended dose is 100 mg twicedaily.

Children: There are no clinical data on the use ofAceclofenac in children under 18 years of age.

Elderly: The pharmacokinetics of Aceclofenac isnot altered in elderly patients, therefore it is notconsidered necessary to modify the dose or dosefrequency.

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PREGNANCY AND BREAST-FEEDING

The safety of this medicine for use duringpregnancy & lactation has not beenestablished.

It is not recommended for use inpregnancy & lactation unless consideredessential by your doctor.

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Side effect

Common side effect: Indigestion,abdominal pain, nausea, diarrhoea &dizziness.

Uncommon side effect: Flatulence,gastritis, constipation, vomiting, ulcersand inflammation, vertigo & skin rash.

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Unique selling propositions:

Stimulates synthesis of extracellular matrix of cartilage.( Bone formation)Blocks degeneration of cartilage matrix.Exhibits better efficacy and tolerability than Diclofenac

Superior to Ketoprofen in Rheumatoid arthritisEnsures high patients and physicians satisfaction

Product positioning:

Painkilis the drug of choice for degenerative cartilage healingand pain killing in Osteoarthritis, Rheumatoid arthritis &Ankylosing spondylitis.

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Target Doctors

Orthopedists specialist

Mild to Moderate pain- Osteoarthritis,

Rhematoid arthritis, Ankylosing

spondylitis

Medicine specialistMild to Moderate pain- Osteoarthritis,Rhematoid arthritis, Ankylosing

spondylitis

Dental surgeon Mild to moderate Dental pain.

GPs / RMP/ PC s

Mild to Moderate pain- Osteoarthritis,

Rhematoid arthritis, Ankylosing

spondylitis, Low back pain.

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Competitors

Brand Company Strength Pack size

Flexi Square 100 mg 10 x 10s

Reservix Incepta 100 mg 10 x 10s

Mervan Aristopharma 100 mg 10 x 10s

Zolfin Beximco 100 mg 10 x 15s

Movex Opsonin 100 mg 10 x 10s

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Promotional Support

1. Literature : 10 pcs/MIO

2. Lizol Floor cleaner : 2 pcs/MIO

3. Imperial Leather Soap : 2 pcs/MIO4. Pen Montex Morris : 2 pcs/MIO

5. Pen Montex Mint : 2 pcs/MIO

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Terminology

Cartilage is a flexible connective tissue found in many areas in the bodies

of humans and other animals, including the joints between bones, the rib

cage, the ear, the nose, the bronchial tubesand the intervertebral discs. It

is not as hard and rigid as bonebut is stiffer and less flexible than muscle

Prostaglandins are found in most tissues and organs. prostaglandins are

produced at the site of inflammation where it is believed that they

mediate many of symptoms of inflammation such as oedema and pain.

Prostacyclin (also called prostaglandin I2 or PGI2)is prostaglandin member of the family. It inhibits platelet activationand is also an effective vasodilator.

Thromboxaneis a vasoconstrictorand a potent hypertensive agent, and it

facilitates platelet aggregation.

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http://en.wikipedia.org/wiki/Bonehttp://en.wikipedia.org/wiki/Rib_cagehttp://en.wikipedia.org/wiki/Rib_cagehttp://en.wikipedia.org/wiki/Earhttp://en.wikipedia.org/wiki/Nosehttp://en.wikipedia.org/wiki/Bronchial_tubeshttp://en.wikipedia.org/wiki/Intervertebral_dischttp://en.wikipedia.org/wiki/Bonehttp://en.wikipedia.org/wiki/Musclehttp://en.wikipedia.org/wiki/Vasoconstrictorhttp://en.wikipedia.org/wiki/Vasoconstrictorhttp://en.wikipedia.org/wiki/Musclehttp://en.wikipedia.org/wiki/Bonehttp://en.wikipedia.org/wiki/Intervertebral_dischttp://en.wikipedia.org/wiki/Bronchial_tubeshttp://en.wikipedia.org/wiki/Nosehttp://en.wikipedia.org/wiki/Earhttp://en.wikipedia.org/wiki/Rib_cagehttp://en.wikipedia.org/wiki/Rib_cagehttp://en.wikipedia.org/wiki/Bone


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Prepared By-

Prashanta Neogi

Product Executive, PMD

VPL 27

Date post:	03-Jun-2018
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Launching Presention Painkil

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