Learning and Memory
Cellular Mechanisms
Zoran Đogaš
Learning objectives for the Seminar S22 (Learning and Memory):
• To understand the concept of Brain Plasticity • Habituation (behavior and synaptic mechanism) • Sensitization (behavior and synaptic
mechanism) • Trisynaptic pathway • Long Term Potentiation in the Hippocampus • Cellular mechanisms of LTP (NMDA / NO)
Post-tetanic potentiation
Monosynaptic reflex in cats Loyd, 1949.
Habituation and Sensitization
Animal model: Aplysia californica
Reflex behavior and cellular mechanisms
E. Kandel et al. Nobel prize
LTP in Hippocampus
Animal model: Rat slices
Long-Term Potentiation cellular mechanisms
NMDA / NO