Li RW 2006

VAT – 3/2006

A Novel Clinical Technique to Treat Amblyopia

Dr. Roger Li BSc(Optom), PhD

Dr. Dennis Levi OD, MS, PhD, FAAO

Collaborators Dr. Pia HoenigDr. Ariella PoppleDr. Karen Young

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Vernier AcuityCan you see the misalignment?

Offset

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3AFC Pick the “odd” one out of 3

Offset

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Positional NoiseJittered Stimulus

Average Position

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Ext. Noise Levelsint N == spatial distortion

in amblyopic vision

L0 : ext N = 0

L1 : ext N < int N

L2 : ext N ≈ int N

L3 : ext N > int N

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Noise LevelsLevel 0 (STRAIGHT !!!)

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Level 1 - slightly jittered

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Level 2 - somewhat jittered

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Level 3 - VERY jittered

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Try This (32-2)

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Getting Harder! (24-3)

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Getting Harder & Harder ! (16-3)

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Getting Harder, Harder & Harder ! (12-1)

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Getting Harder, Harder, Harder & Harder ! (8-1)

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???

Modified StaircaseTriplets (up-down rules)

√√√

√√√

√√√

√√√

√√× √××

×××

√√×

Incr

easi

ng

Diff

icul

ty

Trials

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StaircaseTracking your limits

Diff

icul

t

y

Trials

Easi

er

Hard

er

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Roll down a hillPerceptual learning

Session (2-hr each)

0 10 20 30 40

Per

form

ance

Sco

re

1

10 L0L1L2L3

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Practice makes perfectExercise your BRAIN …

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Can I see better ???Improve Visual Acuity

Session

0 10 20 30 40

Vis

ual

acu

ity

(lo

gM

AR

)

0.2

0.3

0.4

0.5

0.6

0.7

0.8CrowdedUncrowded

S1 S2

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Effective & Efficient

• Intensive, active, challenging

• Enhance vision in “ 50 ” hrs

• Boost brain processing efficiency

• Decrease cortical image distortion

• Useful in adults & children with Amblyopia

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Fuuuurther Information

Li RW, Klein SA & Levi DM. (2006) J of Vis, 6, 311-321.

Chung STL, Levi DM & Li RW. (2006) Vis Res, 46, 1038-1047.

Li RW, Young KG, Hoenig P & Levi DM. (2005) IOVS, 46, 3161-3168.

Levi DM. (2005) Dev Psychobiol, 46, 222-232.

Levi DM, Li RW & Klein SA. (2005) Vis Res, 45, 1793-1805.

Li RW & Levi DM. (2004) J of Vis, 4, 476-487.

Li RW, Levi DM & Klein SA. (2004) Nat Neurosci. 7, 178-183.

Li RW 2006

Thank you

Stay tuned to the upcoming

.……. exciting discovery

http://levilab.berkeley.edu