6
Life magazine, June 4, 1945, vol. 18, page 45-46 .
Life magazine, June 4, 1945, vol. 18, page 45-
46 .
Antigenic Switching
From “Malaria: molecular and clinical analysis”
(M. Walhgren and P. Perlmann, eds.)
Miller, et al., Science, 264: 1878-1883.
Deitsch, K.W. and Hviid, L. (2004), Trends in Parasitology, 20: 562-566
Exon I 5-7 Kb
(hypervariable)
Exon II ~2 Kb
(conserved)Transcription start site
Intron ~1 Kb
+1
Full length mRNA
"Sterile" RNA
Typical var Gene
~60 var genes in each parasite’s genome;
only 1 is transcriptionally active
From: Kyes et al. (2003), Molecular Microbiology 48: 1339-1348.
Smith and Deitsch, J. Exp. Med. 2004;200:1093-1097
