Research

Regenerative Medicine• Biomechanics (Billiar, Gaudette, Lee, Pins, Rolle, Troy, Wen)• Stem cell biology and engineering (Dominko, Gaudette,

Jain, Page)• Tissue engineering (Billiar, Dominko, Gaudette, Jain, Peterson,

Pins, Rolle, Wen)• Biomaterials (Billiar, Camesano, Gaudette, Jain, Peterson,

Pins, Rolle)• Mechanobiology (Billiar, Wen, Lee)

Medical Diagnostics • Biomedical instrumentation (Mendelson)• Telediagnostics (Mendelson)• Biosensors (Camesano, Iannacchione, Jain, Lambert,

Mendelson, Zhou)• Signal processing (Flaherty, Mendelson)• Neutron tomography (Medich)• Mobile health (Mendelson)

Bioinformatics and Computational Biology• Biostatistics, statistical genetics and genomics (Flaherty, Wu)• Biological and biomedical data mining

(Albrecht, Flaherty, Lee, Ruiz)• Simulation of biological systems (Ryder, Troy)• Pharmacokinetic and pharmacodynamic modeling

(Kaminski)• Computational cell biology (Lee)

Bioreactors, Bioprocessing, Bioseparations• Bioreactors – tissue and plant (Billiar, Gaudette, Lambert,

Rolle, Weathers)• Pichia, S. cerevisiae, E. coli expression systems (BioProcess

Center, Rao)• Fermentation development and optimization (BioProcess

Center, Rao)• Biofuels/bioenergy (Clark, Deskins, Rao, Timko,

Thompson, Weathers)

Therapeutics Screening and Development• Delivery, nanomedicine, screening, testing (Camesano,

Dittami, Duffy, Gericke, Jain, Kaminski, Rao, Stroe, Weathers, Zhou)

• High throughput microfluidics (Albrecht, Srinivasan, Zhou) • Cancer Cell Biology (Dominko, Duffy, Gericke, Lee,

Jain, Manning)

Surface Science and Materials Chemistry• Surface functionalization and characterization

(Grimm, Lambert, McDonald)

Neuroscience and Neuroengineering• Degenerative disease/regenerative processes (Adams,

Albrecht, Duffy, Jain, Lambert, Pins, Stroe)• Neuronal imaging and optogenetics (Albrecht, Srinivasan)• Neuronal cell biology (Albrecht, Lee, Srinivasan)• Developmental neuronal biology (Ryder)• Biomaterials for neuron applications (Jain, Zhou)• Behavioral biology (Albrecht, Duffy, Gegear, Matthews)• Traumatic brain injury and stroke (Jain)

Biomedical Imaging and Spectroscopy• Fluorescence spectroscopy and lifetime methods (Connors,

Gericke, Lambert)• Spectroscopic imaging (Lambert)• Time-resolved imaging (Lambert)• IR chemical imaging (Gericke)• Deconvolution imaging (Albrecht, Duffy, Manning, Vidali) • Atomic force microscopy (Camesano, Wen)• Total internal reflection/single molecule fluorescence

microscopy (Gericke)• Confocal (Tuzel, Vidali, Lee, Manning)• MRI for diagnostics of traumatic brain injury (Jain)• Quantitative CT image analysis (Troy)• Quantitative live cell imaging (Lee, Manning, Vidali)

Membrane and Matrix Biology• Extracellular matrix/cell wall biology (Billiar, Camesano,

Duffy, Gericke, Politz, Rao, Rolle, Wen)• Lipid biochemistry, self-assembly (Duffy, Gericke,

Iannacchione, MacDonald)• Membrane proteins (Arguello, Dempski, Dominko,

Duffy, Gericke, Iannacchione, Jain, Kaminski, Page, Ryder, Stroe, Tuzel)

• Protein structure/function and polymerization (Arguello, Dempski, Gericke, Kaminski, Iannacchione, Stroe, Vidali)

Medicinal and Bioorganic Chemistry• Novel synthetic strategies for drug development (Burdette,

Dittami, Emmert)• Synthesis of fluorescent/chromophoric molecules (Burdette)• Novel biomaterial synthesis (Burdette, MacDonald)

Microbiology• Fungal pathogens (Rao)• Tuberculosis (Arguello, Shell)• Prokaryotic molecular genetics (Shell)

WPI approaches life sciences research in a collaborative way, driven by a desire to solve important problems that often cross departmental boundaries. The Life Sciences and Bioengineering Center houses representatives from six academic departments and over 50 faculty members.

LIFE SCIENCES & BIOENGINEERING

Uniquely positioned within a world-renowned, technology-centric research and educational institution

LIFE SCIENCES & BIOENGINEERING

Biology and Biotechnology wpi.edu/+bbt

Dave Adams dadams@wpi.eduTanja Dominko tdominko@wpi.eduJoe Duffy jduffy@wpi.eduRob Gegear rgegear@wpi.eduAmity Manning almanning@wpi.edu Lauren Mathews lmathews@wpi.eduSam Politz spolitz@wpi.eduReeta Rao rpr@wpi.eduLiz Ryder ryder@wpi.eduScarlet Shell sshell@wpi.eduJagan Srinivasan jsrinivasan@wpi.eduLuis Vidali lvidali@wpi.eduPam Weathers weathers@wpi.edu

Bioinformatics and Computational Biology wpi.edu/+bcb

Carolina Ruiz ruiz@wpi.eduZheyang Wu zheyangwu@wpi.edu

Biomedical Engineering wpi.edu/+bme

Dirk Albrecht dalbrecht@wpi.eduKris Billiar kbilliar@wpi.eduPatrick Flaherty pflaherty@wpi.eduGlenn Gaudette gaudette@wpi.eduAnjana Jain ajain@wpi.eduKwonmoo Lee klee@wpi.eduYitzhak Mendelson ym@wpi.eduRay Page rpage@wpi.eduGeorge Pins gpins@wpi.eduMarsha Rolle mrolle@wpi.eduKaren Troy ktroy@wpi.edu

Chemical Engineering wpi.edu/+che

Terri Camesano terric@wpi.eduWilliam Clark wmclark@wpi.eduAaron Deskins nadeskins@wpi.eduAmy Peterson ampeterson@wpi.eduMike Timko mttimko@wpi.edu Robert Thompson rwt@wpi.eduSusan Zhou szhou@wpi.edu

Chemistry and Biochemistry wpi.edu/+cbc

José Arguello arguello@wpi.eduShawn Burdette scburdette@wpi.eduRobert Connors rconnors@wpi.eduRobert Dempski rdempski@wpi.eduJames Dittami jdittami@wpi.eduMarion Emmert mhemmert@wpi.eduArne Gericke agericke@wpi.eduRonald Grimm rlgrimm@wpi.eduGeorge Kaminski gkaminski@wpi.eduChris Lambert clambert@wpi.eduJohn MacDonald jcm@smtp.wpi.edu

Physics wpi.edu/+physics

Germano Iannacchione gsiannac@wpi.eduDavid Medich dcmedich@wpi.eduIzabela Stroe izabela@wpi.eduErkan Tuzel etuzel@wpi.eduQi Wen qwen@wpi.edu

Life Sciences & Bioengineering Faculty

Microscopy/HistologyThe Microscopy/Histology Core provides users the op-portunity to image live, fixed, unlabeled, or fluorescently labeled samples.

• Leica SP5 Point Scanning Confocal/DMI6000 inverted• Zeiss Axiovert 200M inverted• Eppendorf Transfer Man NK2 micromanipulators• Burleigh piezo• Narishige Micro forge and beveler• Atomic Force microscopes• Accuri flow cytometer• Patch-clamping electrophysiology• Applied Biosystems qPCR• Leica cryostat and embedding center • Leica and HM355S microtome• TBS ATPI-120 Tissue Processor

Instrumentation CoreThe Instrumentation Core provides users access to so-phisticated analytical capabilities for characterization of chemical and biological samples.

• Bruker 500MHz NMR spectrometer• Bruker Kappa Apex II single crystal x-ray diffractometer• Bruker D8 Focus powder x-ray diffractometer• Bruker S2 Picofox TXRF spectrometer• Agilent LC/MS System - 6130A single quadrupole• Agilent GC/MS System - 5977A single quadrupole• Bruker Vertex 70 FTIR spectrometer• Perkin Elmer Optima 8000 ICP-OES• Perkin Elmer PinAAcle 900Z GF-AAS• Jasco J-1500 CD spectrometer• Netzsch DSC-214 Polyma• Netzsch TG-209 Libra (TGA)• UV/Vis, Fluorescence, etc.

BioProcess CenterThe WPI BioProcess Center at Gateway Park is equipped with state-of-the-art facilities and skilled scientists leading customized, small-scale bioprocess services. With a highly qualified team designing and applying scalable processes, WPI has been helping industry partners get their research to market faster since the early 1990s.

• NBS Bioflo 3000 fermentors (5L/10L)• Sartorius 100L fermentor• NBS Celligen BLU cell culture bioreactors (5L/10L)• NBS shaker incubators• Microfluidizer M-110Y for cell disruption• Pilot scale Homogenizer• Virtis Shelf Lyophilizer• Multiple small scale TFF Systems• Millipore Pro-Flux TFF system• GE AKTAprime• Agilent (1200 Series) HPLC

Get your research to market… faster.

VivariumThe Vivarium is a 3,500 square foot facility that houses small rodents and aquatics. The facility has 8 housing rooms including a quarantine room and a barrier facility, 2 procedure rooms, laboratory, cage wash room, and a shower.

• 3500 square foot AAALAC accredited facility• Rodents, aquatic animals• 8 housing rooms and 2 procedure rooms

Core FacilitiesThe Core Facilities at the Life Sciences and Bioengineering Center (LSBC) at WorcesterPolytechnic Institute are available for internal and external use on a fee-for-service basis.

Optimize results with our services

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Contact:

Life Sciences & Bioengineering Center Worcester Polytechnic Institute100 Institute RoadWorcester, MA 01609-2280

Andy Butler, Associate Director, LSBC Core Facilities and Operations

+1-508-831-6800abutler@wpi.edu

Centrally located directly off of I-290 in Worcester, Mass., WPI’s LSBC is just a short drive from Boston, Hartford, and Providence.

wpi.edu/+lsbc

LIFE SCIENCES & BIOENGINEERING