Life Sciences Trend Analysis 2013

UNITED KINDGOM

About Us

The following statistical information has been obtained from Biotechgate. Biotechgate is a global, comprehensive, Life Sciences database encompassing the Biotechnology,Pharmaceutical and Medical Device industries. www.biotechgate.com

The UK Biotech Database is a part of the global Biotechgate and is brought to you in partnership with University of Oxford, Oxfordshire economic partnership and One Nucleus; a membership organisation for international life science and healthcare companies. ww.ukbiotech.com

Biotechgate is owned and operated by Venture Valuation AG, a Zurich based company specializing in independent assessment and valuation of technology-driven companies in high growth industries, such as the Life Sciences (Biotech, Pharma, Medtech), ICT, high-tech, Nanotech, Cleantech and Renewable energy. www.venturevaluation.com

Status of the Sector

2012 Statistics

UK 2013 Statistics

614 Total Biotech Companies 664

168 Biotech - Therapeutics 192

394 Biotech - R&D Services 413

52 Biotech - Other 59

91% Percentage of SME's 82%

7% Percentage of Publicly Owned Companies 6%

USD 283 M (2011) Financing/Capital Raised USD 527 M

(2012) 302 Licensing Opportunities 361

Key Activities of Biotechnology Companies

Historical DataSubsector 201

3201

2Contract Research & Manufacturing

18% 17%

Diagnostics and Analytical Services

21% 20%

Bioinformatics & Bioelectronics

4% 4%

Drug Delivery 4% 5%Other Services and Suppliers 25% 26%Therapeutics 16% 16%Other 12% 12%

2013 Data

Bioinformatics and Bioelec-

tronics4%

Contract Re-search and

Manufacturing18%

Diagnostics and Analytical

Services21%

Drug Delivery4%

Other Services and Suppliers

25%Therapeutics

16%

Other12%

2013 Data

Company Foundation Timeline

19951996

19971998

19992000

20012002

20032004

20052006

20072008

20092010

20112012

20130

5

10

15

20

25

30

35

40

45

1 3 5 5 6 49

15 15 1510

610

156 7 6 4 1

56 5

1012 15

17

23

13 13

618

1812

610

64

1

11

21 2

2

2

2 3

1

11

1

1

12

Biotechnology - Therapeutics and DiagnosticsBiotechnology / R&D ServicesBiotechnology - other

Year

No.

of

Com

pani

es F

ound

ed

Company Ownership

Historical DataSubsector 201

3201

2Private/ Independent

75%

74%

Public 6% 7%Subsidiary 19

%19%

Private / inde-pendent

75%

Public6%

Sub-sidiary18%

2013 Data

Sources of Company Foundations

Historical DataCompany Foundation 2013 2012Independent foundation 41% 47%Spin-off from company 2% 3%Spin-off from public institution / NPO 2% 3%Spin-off from university 11% 16%Subsidiary 18% 22%Other 3% 6%

Undisclosed22%

Indepen-dent

founda-tion41%

Merger1%

Spin-off from

company2%

Spin-off from public institution /

NPO2%Spin-off

from univer-

sity11%

Subsidiary18%

Other3%

2013 Data

Number of Employees

Historical DataNo. of Employees 2013 20121-10 28% 28%11-50 38% 33%51-200 16% 30%Greater than 200 18% 6%

1-10:28%

11-50:38%

51-200:16%

201+:18%

2013 No. of Employees

Products in the Pipeline

2013

2012

2013

2012

2013

2012

2013

2012

Prec

linica

lPh

ase

IPh

ase

IIPh

ase

III

0 50 100 150 200 250

192

167

70

65

99

79

30

30

No. of Products

Financing Rounds in the UK & 3 Major Financing Rounds

Financing for 2012/2013 Private Biotech Companies

Major Financings in 2012/2013 Sector USD

MGazasia Ltd Biotech – Other 150

Circassia Limited Biotech – Therapeutics & Diagnostics 76

Cell Medica Ltd Biotech – Therapeutics & Diagnostics 42

2007 2008 2009 2010 2011 20120100200300400500600

0

10

20

30

40

Financing Value Number of Financings

Half YearlyFina

ncin

g V

alue

USD

M

Num

ber

of F

undi

ng

Rou

nds

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The “UK Life Sciences Trend Analysis” is based on data entered in the Biotechgate Database available at www.biotechgate.com. The statistics and graphs in this presentation are based on figures and information entered in this database and we do not guarantee any accuracy hereof.

The use of the figures and graphs provided in this report is free of charge for any presentations as long as www.biotechgate.com is clearly cited as the source. For all other uses please contact us for terms and conditions.

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