As in previous years, the SpecialSymposium Lecture was delivered bySir Hans A. Krebs (Oxford University,Oxford, England) who discussed theredox state of diphosphopyridine nu-

cleotides in regulation of metabolicprocesses. Krebs pointed out that theratio of lactate to pyruvate reflectsthe redox state of dinucleotides in thecytoplasm; the glutamate system indi-cates the position in the mitochondrialmatrix and the beta-hydroxybutyratesystem that in the mitochondrialcrystae. In diabetes the decrease in theratios of the two mitochondrial sys-

tems was contrasted to the increase inthe ratio of the cytoplasmic system.However, in starvation all three sys-

tems moved in the same direction toapproximately the same extent. The ra-

tios were very much lower in the mito-chondrial systems than those of thecytoplasm, differing by a factor of 100in liver from fed or starved animalsand by a factor of 20 in the liver ofdiabetic rats. Krebs pointed out thatthe fact that calculations for the gluta-mate and beta-hydroxybutyrate dehy-drogenase systems led to the same valuesfor the ratio of NAD to NADH2implied that the substrates of thesetwo dehydrogenases were in equilibriumwith the same NAD-NADH2 pool.

Indiana University honored Sir HansA. Krebs at the end of his lecture byawarding a citation of the President ofthe University. Krebs also received the-highest award given by the State ofIndiana when he was made a Sagamoreof the Wabash. In appreciation of hiscontribution to this Symposium seriesover the past half decade, volume 5

of Advances in Enzyme Regulationis dedicated to Sir Hans A. Krebs.The symposium was sponsored by

Indiana University School of Medicine,the American Cancer Society Institu-tional Grant, Hoffman-LaRoche, EliLilly and Co., Merck Sharp & Dohme,The Upjohn Co., and the WellcomeCo. The full text of the papers, editedby George Weber, will be published inthe spring of 1967 as volume 5 ofAdvances in Enzyme Regulation (Perga-mon Press, New York and Oxford).Volumes 1 through 4 of this series ofConferences on Enzyme Regulation inMammalian Systems were published in1963 through 1966 and presented theproceedings- of the previous four sym-

posia.

GEORGE WEBERPharmacology Department,Indiana University School of Medicine,Indianapolis 46207

3 MARCH 1967

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1142

Forthcoming Events

March13-14. Astronautics, symp., Ottawa,

Ont., Canada. (The Secretary, CanadianAeronautics and Space Inst., 77 MetcalfeSt., Ottawa 4, Ont.)

13-14. State Univ. of New York, Down-state Medical Center, "Visiting ScholarLecture Series," Arnold J. Toynbee,Brooklyn, N.Y. (Office of Public Rela-tions, Downstate Med. Ctr., 450 ClarksonAve., Brooklyn, N.Y. 11203)

13-15. 32nd North American Wildlifeand Natural Resources Conf., San Fran-cisco, Calif. (Wildlife Management Inst.,709 Wire Building, Washington, D.C.20005)

13-17. International Laboratory Appa-ratus and Materials Exhibition, London,England. (U.T.P. Exhibitions Ltd., 3Racquet Court, Fleet St., LondonE.C.4)

13-17. Use of Plutonium as a ReactorFuel, intern. symp., Brussels, Belgium.(J. H. Kane, Div. of Technical Informa-tion, U.S. Atomic Energy Commission,Washington, D.C. 20545)

14-15. American Astronautical SOc.5th Goddard Memorial Symp., "The Voy-age to the Planets," Washington, D.C.(M. B. Lees, General Electric Co., DefensePrograms Div., 777 14th St., NW, Wash-ington, D.C. 20005)

14-15. Space, natl. mtg., Los Angeles,Calif. (D. P. Chandler, 3370 MiralomaAve., Anaheim, Calif. 82803)

14-15. Temperature Measurements Soc.,5th conf., Los Angeles, Calif. (R. A.Finch, Conf. and Exhibit Chairman,Atomics International, P.O. Box 309,Canoga Park, Calif. 91304)

15-17. Instrumentation for the Ironand Steel Industry, Natl. Instrument Soc.of America, 17th conf., Pittsburgh, Pa.(F. J. Barchfeld, Jones & Laughlin SteelCorp., 900 Agnew Rd., Pittsburgh 15230)

15-17. New Jersey Mosquito Extermi-nation Assoc., 54th annual mtg., AtlanticCity, N.J. (D. M. Jobbins, Dept. of Ento-mology and Econ. Zoology, Rutgers-State Univ., New Brunswick, N.J.)

16-17. Hypervelocity Techniques, 5thsymp., Denver, Colo. (A. A. Ezra, Re-search Inst., Univ. of Denver, Denver80201)

16-18. Geological Soc. of America,Northeastern Sect., 2nd annual, Boston,Mass. (M. Prinz, Tufts Univ., Medford,Mass.)

16-18. Texas Acad. of Science, CollegeStation, Tex. (W. E. Norris, Jr., BiologyDept., Southwest Tex. State Coll., SanMarcos, Tex. 78666)

16-19. International Assoc. for DentalResearch, 45th general mtg., Washington,D.C. (G. H. Rovelstadt, c/o Navy DentalSchool, Nat]. Naval Medical Center,Bethesda, Md. 20014)

17-19. Fourth Intern. Vacuum Con-gress, Univ. of Manchester Inst. of Sci-ence and Technology, Manchester, Eng-land. (The Secretary, Joint British Com-mittee for Vacuum Science and Technol-

ogy, 47 Belgrave Sq., London, S.W.1,England)

17-21. National Science Teachers As-soc., conv., Detroit, Mich. (Executive Sec-retary, NSTA, 1201 16th St., NW, Wash-ington, D.C. 20036)

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SCIENCE, VOL. 155

Researchers'Research Book

DIRECTORYOF SELECTEDRESEARCHINSTITUTESIN EASTERNEUROPEPrepared byArthur D. Little, Inc.for the NationalScience FoundationA directory of 861 scien-tific, engineering, agri-cultural, and economicresearch institutes in Bul-garia, Czechoslovakia,Hungary, Poland, Ru-mania, and Yugoslavia.

$12.00

COLUMBIAUNIVERSITY PRESS440 West 110th StreetNew York, N.Y 10025

18-19. Twelfth Annual Natl. Conf. onLinguistics, New York, N.Y. (L. Pap,State Univ. College, Div. of ForeignLanguages, New Paltz, N.Y.)

19-24. Southeastern Surgical Congress,Bal Harbour, Fla. (A. H. Letton, Execu-tive Secretary, 340 Boulevard N.E., At-lanta, Ga. 30312)

19-26. Canadian-American Medical andDental Assoc., Vail, Colo. (T. Trapasso,Secretary, 816 Ashmum St., Sault Ste.Marie, Mich. 49783)

20-23. Institute of Electrical & Elec-tronics Engineers, intern. conv., New York,N.Y. (A. B. Giordano, The Institute, 345E. 47 St., New York 10017)

20. Field-Ion Microscopy, mtg., Cam-bridge, England. (Meetings Officer, Inst.of Physics and Physical Society, 47 Bel-grave Sq., London S.W.1, England)

20-22. Physical Electronics, annualconf., Cambridge, Mass. (Research Lab. ofElectronics, Massachusetts Inst. of Tech-nology, Cambridge)

22-24. American Astronautical Soc.,Rocky Mountain Section, mtg., NewMexico State Univ., University Park, N.M.(A. Vick, Box 996, Las Cruces, N.M.)22-24. Astrogeology, symp., University

of Michigan, Ann Arbor, Mich. (E. W.Heinrich, Dept. of Geology and Mineral-ogy, Univ. of Michigan, Ann Arbor 48104)

22-24. Modern Optics, intern. symp.,New York, N.Y. (J. Fox, PolytechnicInst. of Brooklyn, 333 Jay St., Brooklyn,N.Y. 1 1201)

23-24. Seismological Soc. of America,Santa Barbara, Calif. (D. Tocher, U.S.Earthquake Mechanism Lab./ESSA, 390Main St., San Francisco, Calif. 94105)-23-24. Social Facilitation and Imitation

Behavior, symp., Miami Univ., Oxford,Ohio. (E. C. Simmel, Dept. of Psychology,Miami Univ., Oxford 45056)

23-25. American Ethnological Soc.,mtg., San Francisco, Calif. (J. M. Collins,Div. of Social Sciences, Southern IllinoisUniv., Edwardsville)

23-25. Institute of Mathematical Sta-tistics, central regional mtg., Columbus,Ohio. (G. E. Nicholson, Jr., Dept. of Sta-tistics, Univ. of North Carolina, ChapelHill 27515)

23-25. Society of Toxicology, Atlanta,Ga. (C. S. Weil, Mellon Inst., 4400 FifthAve., Pittsburgh, Pa. 15213)

23-25. Underwater Archaeology, 3rdconf., Miami, Fla. (S. Schnier, NewsBureau, Univ. of Miami, Coral Gables,Fla. 33124)

24-26. Image Detection and Processing,-conf., Royal Radar Establishment, GreatMalvern, Worchestershire, England. (Meet-ings Officer, Inst. of Physics and PhysicalSoc., 47 Belgrave Sq., London, S.W.1,England)

26-30. Association of American Geog-raphers, 63rd annual mtg., St. Louis, Mo.(Executive Officer, 1146 16th St., NW,Washington, D.C. 20036)

27-30. American Physical Soc., Chi-cago, Ill. (R. G. Sachs, P.O Box 344,Argonne, Ill.)

27-30. Canadian Inst. of Mining andMetallurgy, 69th annual mtg., Ottawa,Ont., Canada. (Secretary, 121 RichmondSt. W., Toronto 1, Ont.)

28-30. Engineering Aspects of Mag-netohydrodynamics, Stanford, Calif. (R.H. Eustis, Stanford Univ., Stanford)

3 MARCH 1967

BASICMICROSCOPICTECHNICSBy Ruth McClung Jones

This new modern handbook for beginning and inter-mediate students in the biological sciences is based onMichael Guyer's famous Animal Micrology. It retainsthe diversity of method for which the Guyer book wasfamous, but follows a different arrangement in mostof the methods presented. More than two-thirds of thetechnics included in this new work were not in exis-tence when Guyer's fifth edition was published in1953. Dr. Jones has tested these new technics to makecertain they are suitable for use by relatively inexperi-enced students. The result is an up-to-date basic textthat is also an excellent hand reference for biologicalresearchers. Basic Microscopic Technics is ideal forcourses in histological technics, clinical pathology, andmedical technology.Some of the new methods described are: simpler, time-saving technics for preparing bone-vital stainingtechnics, especially for intercellular substances andconnective tissue cytological technics suitable forkaryotype analysis that eliminate sectioning-methodsof preparing tissue for identification of sex chromatinbodies-methods for mounting specimens in plastic-'histological methods-new technics for demonstratingsmall blood vessels and lymphatics in sections and inthin whole mounts-and recently developed aqueousmountants. 352 pages. $6.50

INVERTEBRATENERVOUS SYSTEMSTheir Significance for Mammalian NeurophysiologyEdited by C. A. G. Wiersma

"How did the simplest animal reflexes that could becalled nervous arise and how, out of these primitiveactivities, did that enormously complex body of re-sponses that we look on as evidence of mentality inhigher creatures like ourselves originate?" This ques-tion forms the basis of this volume and the research ofits 34 contributors. These are the published proceed-ings of the Conference on Invertebrate Nervous Sys-tems held at the California Institute of Technology(1966) under the sponsorship of CIT and the National

75th Year Institute of Health. $10.00

Inquire at your bookstoreUNIVERSITY OF CHICAGO PRESS

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POSITIONS WANTED flflfl

(a) Biochemistry Ph.D. 1967, microbiology minordesires clinical or industrial position. (b) AnimaQNtrvition, Physiology Ph.D.; taught universitymedical school anatomy, embryology; nutritionalresearch- prefers academic or research appoint-ment. Write Woodward Medical Personnel Bu-reau, 185 North Wabash, Chicago 60601. X

POSITIONS OPEN

BIOCHEMICAL ENGINEERINGMathematician-programmer required as spearheadon computer methods with small team developingnovel automated systems of biochemical analysisfor medical and biological research. Experienceat assembler level desirable but not essential ifmath. logic, or O.R. Salary approx. $10,000. Ap-plications to Dr. I. E. Bush, Worcester Founda-tion for Experimental Biology, 222 Maple Ave-nue, Slrewsbury, Mass. 01545.

CLINICAL CHEMIST AND MICROBIOLOGISTCHEMIST, Ph.D., with no less than 2 years experiencein an approved clinical -laboratory. Will supervise bio-chemical activities of clinical lab and design and conductvarious 'research projects. MICROBIOLOGIST, Ph.D., inMicrobiology (Bacteriology) with no less than 2 yearspostdoctoral experience in clinical microbiology. Willsupervise diagnostic bacteriology studies in clinical laband be responsible for bacteriologic investigations on in-terdisciplinary research contracts.Young vigorous life science service organization with

Impressive growth record and exciting career potential.Suburban location adjacent to Washington, D.C., pro-vides pleasant and stimulating opportunities for cultural,intellectual, and leisure enjoyment. Opportunity for at-tending scientific meetings and publications. Salariesflexible to meet good qualiflcations. Excellent companybenefits. BIONETIC;S RESEARCH LABORATORIES,INC., P.O. Box 26, Falls Church, Virgilnia 22046.

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CHEMIST: M.S. or experienced B.S. Experiencedin clinical biochemical procedures and modemanalytical methodologies. Opportunities for aca-demic advancement. Please write to: Hipolite V.Nlno, Ph.D., Clinical Biochemistry Laboratory,North Carolina Memorial Hospital, University ofNorth Carolina, Chapel Hill, North Carolina17514.

PREDOCTORAL AND POSTDOCTORALTRAINEESHIPS IN NEUROPHYSIOLOGY

are available in the Department of Physiology,New York Medical College. Applications are m-vited from candidates who wish to enroll in thePh.D. program leading to a degree in Physiologyand from candidates who have completed or willshortly complete the requirements for either thePh.D. or M.D. degree.Topics: sensorimotor organization; cerebral con-trol mechanisms; neural control of water andelectrolyte metabolism; neural excitation.Stipends: PREDOCTORAL, $2400 (tax exempt)yearly plus allowances for experience and depend-ents. Tuition is paid.

POSTDOCTORAL, $5000 (partially taxexempt) plus allowances for experience and de-pendents.

SPECIAL FELLOWSHIPS are alsoavailable.Direct inquiries to: Dr. V. B. Brooks, Professorand Chairman, Department of Physiology, NewYork Medical College, 1 East 106 St., New York,N.Y. 10029.

PREDOCTORAL TRAINEESHIPS INCARDIOVASCULAR AND RENAL PHYSIOLOGY

are available in the Department of Physiology,New York Medical College. Applications are in-vited from candidates who wish to enroll in thePh.D. program leading to a degree in Physiology.

Topics: cardiovascular physiology, experimentalhypertension, renal electrolyte excretion.

Stipend: $2400 (tax exempt) plus allowance forexperience and dependents. Tuition is paid.

Direct inquiries to: Dr. V. B. Brooks, Professorand Chairman, Department of Physiology, NewYork Meical CoBege, 1 East 106 St., New York,N.Y. 1029.

UP IPOSMONS OPEN|||| || -

ENZYME CHEMIST (RESEARCH)-Ph.D. or M.D.with experience. To work in the field of tissue enzymes,as related to lipoidoses. Full-time position at well-known hospital-affiliated Research Institute in New YorkCity. SALARY-$12,000 per annum plus fringe benefitsand Increments. Send detailed curriculum vitae andreferences to: BOX 320, SCIENCE.

Epidemiologist-to plan and direct studiesof birth defects conducted by the Epidem-iology Branch at the Dental Health Cen-ter of the U.S. Public Health Service inSan Francisco. M.D. degree and advancedtraining and experience in epidemiologyrequired. Specialized training in pediatricsand/or genetics preferred but not manda-tory. Salary commensurate with qualifica-tions. Federal Civil Service appointment;relevant benefits and standards apply. Non-discrimination in employment. SubmitForm SF-57 (obtainable from any PostOffice or Federal Agency) to: Miss SylviaHay, Dental Health Center, 14th Avenueand Lake Street, San Francisco, California94118.

POSMTION AVAILABLE:Statistidan and Biostatistidan with Ph.D. to or-ganize and head statistics program. Academic ap-pointment. Salary $12,000 to $15,000 to start, In-creases to $23,000. Midsouth.

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SCIENCE, VOL. 155

THE WORLD HEALTH ORGANIZATIONrequires a

MEDICAL OFFICER OR SCIENTISTIN HUMAN GENETICS

Applications are invited for the post of Chief of the HUMANC;NETICS UNIT, to plan and guide the Organization's pro-gramme in human genetics and to develop international co-ordina-tion of research in this field.The incumbent will be called upon to provide guidance and

technical advice to Member States of WHO in the field of humangenetics, particularly with reference to training and research. Hewill be required to prepare scientific meetings, training courses,etc., and to maintain liaison with organizations having relatedinterests.A doctorate in medicine and/or science is required, with ex-

tensive research experience in human genetics. A thoroughknowledge of the present status and trends of research in humangenetics, and of the importance of this subject to further progressin the understanding of health and disease is essential.The salary, net of tax, is of US $13,110 rising by annual in-

crements to US $16,035, to which should be added a post adjust-ment alowance of US $376 for a single person and US $564 fora married person. Other allowances include a dependents' allow-ance and an education grant for children. Other benefits: re-patriation grant, home and annual leave, sickness and accidentinsurance, pension fund. Initial contract for two years.

Applications and curriculum vitae should be sent to Chief, Per-sonnel (CAND-HG), World Health Organization, Avenue Appia,Geneva, within one month of the publication of this announce-ment. The Organization regrets that it will be able to send repliesonly to candidates whose applications are under serious consid-eration.

New AAAS Symposium Volume

ENVIRONMENTAL VARIABLESIN ORAL DISEASE

Editors, Seymour J. Kreshover and F. J. McClure,328 pp., illus., bibliography index, 1966. Price:$8.75. AAAS members' cash orders: $7.75.

Recent research on the role of environmentalfactors in oral disease is reported in this collectionof papers from a symposium held at the AAASmeeting in Montreal, December 1964.

Twenty-four distinguished scientists presenttheir findings in 17 chapters under four generalheadings:Geographical and clinical consideration.Nutrition and dental caries.Experimental considerations in oral soft tissue

lesions.Prenatally induced oral anomalies.

AMERICAN ASSOCIATIONFOR THE

ADVANCEMENT OF SCIENCE1515 Massachusetts Ave., N.W.

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