LIST OF PARTICIPANTS/LECTURERS

Or. Judit Balazs ~niversity of Medicine pepartment of Psychiatry and Psychotherapy aalassa u. 6. Budapest H-1083 HUNGARY

Or. Silvia Borissova iUniversity Hospital !section of Social Psychiatry

11 "St. Georgii Sofiiski" Street ,BULGARIA

Dr. Pat Brennan Emory University Department of Psychology Altanta, GA 30322 USA

Dr:-Sertalan Csillik Bay Zoltan Foundation for Applied Research Institute for Biotechnology Derkovits fasor 2 H-6726 HUNGARY

Dr. Frantisek Faltus Charles University Department of Psychiatry Ke Karlovu 11 Ke Karlovu 11 128 08 Praha 2 CZECH REPUBLIC

Dr. Antonio Castro Fonseca Universidade de Coimbra Faculdade de Psicologia e de Ciencias da Educacao 3000 Coimbra PORTUGAL

Dr. Kimon Ganev University Psychiatric Clinic Section of Social Psychiatry 1 G. Sofiiski Street 1431 Sofia BULGARIA

253

Dr. Istvan Bitter Institute for Postgraduate Education Department of Psychiatry and Psychotherapy Blassa u.6. Budapest H-1083 HUNGARY

Dr. John Brekke University of Southern California School of Social Work University Park Los Angeles, CA 90089-0411 USA

Dr. Barbara Cornblatt Hillside Hospital Psychiatry R~search 75-59 263'" Street Glen Oaks, NY 11004 USA

Dr. Vitaliy Egorov Crimean Psychiatric Hospital #1 Department of Forensic Psychiatry R. Luxemburg str. 27 Simferopol 333006 Crimea UKRAINE

Dr. Maria Luiza Flonta University of Bucharest Department of Biology Splaiullndependentei 91-95 76201 Bucharest ROMANIA

Dr. Svein Friis Ulleval University Hospital Department of Research and Education Division of Psychiatry N-0407 Oslo NORWAY

Dr. Damianka Getova Medical University Department of Pharmacology Evlogy Georgiev str. 155 1504 Sofia BULGARIA

254

Dr. Ian Falloon Via Case Sparse 10 28040 Lesa Novara ITALY

Dr. Matti Huttunen Kolmas Linja 20 821 00530 Helsinki 53 FINLAND

Dr. Peter Jones University of Nottingham Division of Psychiatry Duncan Maanillan House Porchester Road Nottingham. NG3 BAA UNITED KINGDOM

Dr. William McFarlane Maine Medical Center Department of Psychiatry 22 Bramhall Street Portland. ME 04102 USA

Dr. Patrick McGorry University of Melbourne Department of Psychiatry Locked 8ag 10 Parkville Victoria 3052 AUSTRALIA

Dr. Diana Perkins University of North Carolina Neuroscience Hospital Department of Psychiatry Chapel Hill. NC 27599-7160

Dr. Raimo K. Salokangas University of Turku Department of Psychiatry PL52 FIN 20521 Turku FINLAND

Dr. Heinze Hafner Central Institute of Mental Health Durchwahl 17 03-726 J568159 Mannheim GERMANY

Dr. Jan Olav Johannessen Rogaland Psychiatric Hospital Box 1163 Hillevag 4004 Stavanger NORWAY

Dr. Jan LibiQer Psychiatric Center Prague Ustavni 91 Praha 8-Bonice CZ-181-03 CZECH REPUBLIC

Dr. Tom McGlashan Yale Psychiatric Institute 184 Liberty Street New Haven. CT 06519 USA

Dr. Samoff Mednick University of Southern California Social Science Research Institute University Park 851 Los Angeles. CA 90089-0375 USA

Dr. Gary Remington Clarke Institute of Psychiatry 250 College Street. 111h Floor Toronto. M5T 1R8 CANADA

Dr. Jean Addington Foothill Medical Centre Department of Psychiatry 1403-29 Street Calgary. Alberta T2W 2T9 CANADA

Dr. Judit Harangozo II,wakenings Foundation <alvaria ter 5 -i-1083 Budapest -iUNGARY

Dr. Jiri Horacek :>rague Psychiatric Center Jstavni 91 181 03 Praha 8 Bohnice :;ZECH REPUBLIC

Dr. Bartosz Janikowski Psychiatricka leeebna Bohnice Ustavni 91 181 02 Praha 8 CZECH REPUBLIC

Dr. Marga Kocmur University Psychiatric Hospital Outpatient Services 1000 Ljubljana Njegoseva4 SLOVENIA

Dr. Don Linszen Adolescenten Kliniek AMClDe Meren Tafelbergweg 25 1105 BC Amsterdam THE NETHERLANDS

Dr. Michael Marsalek Mental Hospital Ustavni 91 Praha 8 Bohnice 181 02 CZECH REPUBLIC

Dr. Ross Norman London Health Science Center Department of Psychiatry Room 1138 392 South Street WMCH London, Ontario N6A-4G5 CANADA

Dr. Sheilagh Hodgins Universite de Montreal Department of Psychology C.P. 6128, Succ. Centre-Ville Montreal, Quebec H3C 3J7 CANADA

Dr. Peeter Jaansen Tartu University Psychiatric Hospital Raja 31 EE 2400 Tartu ESTONIA

Dr. Matcheri Keshavan Western Psychiatric Institute & Ciinic 3811 O'Hara Street Pittsburgh, PA 15213 USA

Dr. T. K. Larsen Researcher in TIPS Rogaland Psychiatric Hospital Armauer Hansensv 20 N-4016 Stavanger NORWAY

Dr. Dragos Marinescu Clinical Hospital No 3 Craiova Calea Bucuresti No. 126 1100 Craiova ROMANIA

Dr. Tandy Miller Yale Psychiatric Institute 184 liberty Street New Haven, CT 06519 USA

Dr. Virginija Novak Grubi Psihiatricna Klinika Studenec48 1260 Ljubljana SLOVENIA

255

256

Dr. Erika Perczel Awakenings Foundation Kalvaria ter 5 H-1083 Budapest HUNGARY

Dr. Jiri Raboch University Karlovy PSchiatricka Klinika Ke Karlovu 12802 Prague 2 CZECH REPUBLIC

Susan A. Stack University of Southem California Social Science Research Institute University Park 8-51 Los Angeles, CA 90089-0375 USA

Dr _ -Jarornir Svestka Faculty Hospital University Psychiatric Department Jihlavaka Street 20 63900 Brno CZECH REPUBLIC

Dyanne E. Van Peter University of Southern California Social Science Research Institute University Park B-51 Los Angeles, CA 90089-0375 USA

Dr. Svetlozar Vassilev University Psychiatric Clinic Section of Social Psychiatry 1 G. Sofiiski Street 1431 Sofia BULGARIA

Dr. Petr Zvolsky First Medical Faculty of Medicine Charles University Department of Psychiatry Ke Karlovu 11 12801 Praha 2 CZECH REPUBLIC

Dr. Boisteanu Petru Sp. CliniC de Psihiatrie Socola Str. Bucium No. 36 lasi ROMANIA

Dr. Erik Simonsen Inst. Of Personality Theory & Psychopathology Amtssygehuset Fjorden Smedegade 16 Dk-4000 Roskilde DENMARK

Dr. Teodora Stoeva University of Sofia Department of Social Psychology Bul. Evlogy Georgiev, 56 1124 Sofia BULGARIA

Dr. Kay Thomas Wolston Park Hospital Wolston Park Road WACOL Queenland 4076 AUSTRALIA

Dr. Veiko Vasar Tartu University Psychiatric Hospital Raja 31 EE 2400 Tartu ESTONIA

Dr. Robert Zipursky Clarke Institute of Psychiatry Schizophrenia Division 250 College Street Toronto M5T 1R8 CANADA

Subject Index

ABC Schizophrenia Study, 77, 78, 95 Acute care, 125 Acute psychosis, 114, 115,118 Adjustment disorders, 130 Adolescence, late,

affective development in, 207 cognitive development in, 206 depression in, 207 developmental tasks in, 206 neocortex development in, 206 prefrontal cortical deficit in, 207 prodromal period in, 207 psychotic predisposition in, 207 as risk period, 233

Affective disorder, 2,18,125,130,132, 152, 198, 199 Affective flattening, 85, 86, 243 Affective psychosis, 108 Affective symptoms, 79, 82 Aggressive behavior, 93 Agoraphobia, 128 Alcohol abuse, 93,95 Alcohol dependence, 63 Alloplastic personality disorders, 48 Ambient stress, 128 American Psychiatric Association, 27,43,174 Antidepressant medication, 140, 168, 205 Antioxidants, 239, 240, 241, 246 Antipsychotic treatment, 96, 140, 152, 182,198,205,233,234

atypical, 115 low-dose therapy, 116, 127, 169, 173, 176, 186, 187, 189, 214,215,223 medications, 167-176, 183-188, 190 side effects of, 170-172

Antisocial behavior, 93 Anxiety disorders, 130 Apoptosis, 236, 245 Assertive Community Treatment (ACf),211

257

At-risk group, III At-risk prodromal states, 56, 58,103, 105, 107, 136 Attenuated Positive Symptom Prodromal State, 138 Attenuated psychosis, 55, 56 Attenuated symptoms, 102, 107, 136-138,140,214 Auditory hallucinations, 80, 81 Autoimmune disorder, 236 Autonomic nervous system

responsiveness of, 49 Baseline risk,

of disorder,24 Basic Symptom Concept, 54, 73, 109 Behavior dimensions,

adolescent, 22 externalizing, 11,13,19 internalizing, 11,13, 19

Beck Depression Inventory (BOI), 126 Biological disposition, 183 Biopsychosocial assessment, 126 Biosocial Hypothesis, 199 Bipolar disorder, 101, 138, 169, 182, 200-202,204,205,211 Birth complications, 31,32,38,39,41 Bonn Scale for the Assessment of Basic Symptoms (BSABS), 5172, 75 Brief Psychiatric Rating Scale (BPRS), 107-109,138,170,191,212 Brain,

changesin,232,234 frontallobe,51,234 functional abnormalities in, 183 hippocampus, 111, 118,232 prefrontal cortex, 51, 57 reduced volume, 51, 57, 232 in schizophrenic patients, 51 structural abnormalities in, 183

temporal cortex, 58 temporal lobe, 51, 234 volume, 109, 110, 112, 118

Brief Intermittent Psychotic Prodromal State, 138, 139

258

Brief Limited Intermittent Psychotic Symptoms (BLIPS), 107, 108 Buckingham Project, 124, 128,212 Camarillo County Study, 185 Cannabis dependence, 109 Caregiver morbidity, 128, 129 Catatonia, 149 CATEGO,91

depression, 84, 86 Causal models, 204

longitudinal dimension in, 19

Central nervous system (CNS), 51, 52, 57,168,174 Cerebral deficits,

in schizophrenics, 51 in relatives of schizophrenics, 51

Charing Cross Health Index (CXD), 129 Childhood risk factors,11 Chlorpromazine, 171, 186, 198 Chlorproxithene, 189 Chlothiapine, 189 Clozapine, 171,172,175, 184, 185, 188-191,244

agranulocytosis in, 185 Clinical management, 131 Clinical morbidity, 128, 129 Cognitive Behavioral Marital and Family Carer Strategies, 127 Cognitive deficits, 95, 201, 205 Cognitive,

disturbance, 232 dysfunction, 202 function, abnormalities in, 204 impairment, 243 symptoms, 181

Cognitively Oriented Psychotherapy for Early Psychosis (COPE), 216, 222 Community Health Record of Risk Factors, 126 Comprehensive Assessment of Symptoms and History (CASH), 107, 108 Conceptual disorganization, 65, 107, 139,144, 150

Cortical serotonin receptors, 62 Cortisol levels, 118 Copenhagen High Risk Project, 29, 33, 48,72

DSM-III-R,31 Prediction of Schizophrenic Outcome by Premorbid Factors, 39

Cox proportional hazard model, 109 CSF volume, 52 Current And Past Psychopathology Scale (CAPPS), 30 D2 antagonists, 172 D2 blockade, 172, 174, 175 D2 receptors, 186, 187, 189 D2 occupancy, 172-174, 186 DEEP Project, 47,56,57,58,60,65 Deficit symptoms, 187,214 Delusional disorder, 155 Delusions, 81,108,137,143,144,150, 182

paranoid, 80 Depression, 83-86, 95, 96, 105,139, 140,149,168,198,203,204

depressive disorders, 131,211 depressive episodes, 83 depressive mood, 81, 83 depressive symptoms, 81-86, 109 depressive syndrome, 86, 87 in patients' family members, 204

Developmental anomalies, 74, 88 defects, 199 delay, 17,54 disability, 108 milestones, missed, 17, 54 predictors, 2

Deviant behavior in adolescent schoolchildren, 34

Dex-fenfluramin, 191 Diagnostic and Statistical Manual, revised third edition (DSM III-R), 30, 60,74,106,129,130, 152, 158

Diagnostic and Statistical Manual, revised fourth edition (DSM-IV-R), 63, 64, 108, 110, 137, 138, 181 Disability Assessment Schedule (DAS), 75,87,93 Discriminant function analysis (DFA), 35-40 Discrimination/prediction performance, 15 Disorganized symptoms, 138, 142, 143, 147, 150 Dissocial behavior, 93 Dopamine,183, 240, 246

activity, increased, 57 receptors, 183,239

Dopaminergic dysfunction, 183 Drug interventions, 128 Duration of Illness (DUI), 152 Duration of Untreated Psychosis (DUP), 71,72,152,153,155,156,160,163,198, 233 Dysphoric mood, 149,150 Early Detection, Intervention, and Prevention (EDIP), 215 Early illness, 77, 81, 83, 89, 92 Early intervention, 72, 96, Ill, 113, 117,119,123-125,132,136,139,152-154,158,167,184,198,200,205,210, 212,215-218

family intervention, 205 during neurodevelopment, 168 mental health services, 123, 124 primary care, 123-125 outcome evaluation, 123

Early Psychosis Assessment Team (EPAT),213 Early Psychosis Prevention and Intervention Center (EPPIC), 117, 153, 213,222 Early response genes, 189 Early signs questionnaire, 126 Eating Attitudes Test (EAT), 126 Educational attainment data, 25

Emotional response decreased, 146, 150 lack of, 146

Environmental changes, 110 factors, and risk of

schizophrenia, 231, 232 family, 130 marital, 130

259

stressors, 32,34, 56, 125,232 variables, 205

Epidemiology, 47 Executive functions, 51, 62 Expressed Emotion (EE), 201, 209, 212, 220

and relapse reduction, 212 Extrapyramidal symptoms (EPS), 170-174, 186, 188, 189 F N-methylspiro-peridol, 191 Family-aided Assertive Community Treatment (FACT), 198,211,215 Family history, 125 Family intervention, 200, 212, 223 Family Psychoeducation (FPE), 199, 200,211

and reduction in relapse, 211 Finnish Adoptive Family Study of Schizophrenia, 49 First-degree relatives, 106, 107 , 138, 140,145,231

of schizophrenic patients, 47, 58,59,60,61,63,64

alcoholism in, 48 schizophrenia in, 213 schizo typal personality

disorders in, 48 First episode psychosis, 110, 113, 152-154,167-169,173-176,197,199,200, 214

pharmacotherapy in, 167, 169 First episode schizophrenia, 151, 154, 155,181-184,186,190,203,210,233, 241

low-dose treatment in, 190 subtypes of, 190

Fluphenazine, 173

260

Frank disorder, 110 Frank psychosis, 53, 56, 72, 101-103, 108,176,215 Frank schizophrenia, 102 Free radicals, 237, 238, 240, 241, 245, 246

and cell function, 238 and polyunsaturated fatty acids

(PUPA), 238 and DNA, 238 and dopamine receptors, 239

Functional decline, 153 deficit, 197, 198 deterioration, 168,221 disability, 136,208,215

Functional impairment, 75, 87, 93, 115, 152 Functional Magnetic Resonance Imaging (FMRI), 57, 62 Functional deficits

in schizophrenic patients, 50 GABA system, 114 Generalized Anxiety Disorder, 65 General practitioner, 154, 157, 158, 162-164,213 General symptoms, 138,142,143, 148, 150 Genetic predisposition, 62-65

Genetic risk, 21,24,25, 29-32,34, 38-41, 72,136-138,140,199,231,236

and deterioration Prodromal state, 138, 140

and difficulty with executive functioning, 50

and memory difficulties, 50 and psychotic reactions, 51

Genotype, 235 Gestational disruption, 32 Global Assessment of Functional Ability (GAp), 61, 63-65,107, 109, 138-140,159,160,214 Global Assessment of Functioning Scale (GAS), 72 Glutamate receptors, 241, 242, 244, 245 Glutamatergic dysfunction, 241, 245

Grandiosity, 137, 144, 150 Hallucinations, 137, 144, 150, 182,243

auditory, 80, 81 Hamilton Rating Scale for Anxiety, 126 Hamilton Rating Scale for Depression, 126 Haloperidol, 108, 171-175, 186-191

and prolactin response, 191 Hayling Sentence Completion test, 50 High-risk group, 5,10,21,22,30,34,47, 48,49,72,108,109,116,125

Copenhagen study, 30,31,32,33,35,36,39,41

for psychosis, 52 lower IQ in, 50 reduction in executive

function, 50, 51 schoolchildren in England,

Scotland, and Wales, 5, 10 subjects who developed

schizophrenia, 35 timid daydreamers in, 10, 20,24

High Risk Project Copenhagen, 29,33 Israeli, 34, 72 New York, 35, 72,105 OB Copenhagen, 40

Hippocampus structural changes in, Ill, 118 volume of, 109,110, 112, 118

Home-based Intensive Care, 127 Hybrid/Interactive model, 55, 56 Hypothalamic-Pituitary-Adrenal Axis (HPA-Axis), 118 ICD-lO criteria, 82,181 Immune dysfunction, 236, 237 Impaired social behavior, 89 Incipient psychosis, 80, 86, 207 Indicators of risk,

familial, 96 neuropsychological, 96 neurobiological, 96

Instrument for the Retrospective Assessment

of the Onset of Schizophrenia (IRAOS), 53 74-78, 81, 82, 87, 93 Integrated Mental Health Service, 129, 130, 131 International Classification of Diseases, eighth revision (ICD-8), 30 Intervention

clinical, 128 early, 72, 96,111,113,119, 123-125 pharmacological, 115 premorbid 29,35,39,41 preventive, 42, 115 psychopharmacological, 42 psychosocial, 42 targeted, 126 therapeutic, 127, 128

Israeli High Risk Study, 34, 72 Late fetal development, 232, 245 Latent psychotic trend, 48 Latent trait analysis, 10, 13, 23 Lifetime History of Neuroleptic Treatment, (LHNT), 61 Living Skills Training, 127 Logistic regression models, 15,23 Low-risk group, 29, 30

in Copenhagen study, 30, 31, 32,37,41 schoolchildren, 49

Magnetic Resonance Imaging (MRI), 57,62,110, 111, 118,234 Magnetic Resonance Spectroscopy, 111 Manic depressive disorder, 161 Markers for psychosis,

biological, 115 milestone achievement, 111 neurocognitive functioning, 111 neurological abnormalities, 111 obstetric complications, 111 poor premorbid adjustment, 111

Mauritius study, 42 ANS hyperresponders in, 42 preschool intervention in, 42

Membrane phospholipid model, 114 Medical morbidity, 132 Medications,

261

antidepressant, 140 168,205 antipsychotic, 140, 152, 167-169, 183-188, 190, 198,205, 233,234 antixiolytics, 168 chlorpromazine, 171, 186, 198 chlorprothixene, 189 c1othiapine, 189 c1ozapine, 171, 172, 175, 184, 185,188-191,244 dex-fenfluramin,191 fluphenazine, 173 F N-methylspiro-peridol, 191 haloperidol, 108, 171-175, 186-191 neuroleptic, 108,113, 117, 151, 152, 184-187, 189, 191, 192, 213,240,241 olanzapine, 156, 170-172, 189, 223,244 PCP, 242-245 perphenazine, 156, 188, 189 phenothiazine, 184 psychotomimetics, 243 psychotogenic lysergic acid

(LSD), 191,243 quetiapine, 172, 175,223 risperidone, 116, 156, 170-173, 186, 188, 189 thioridazine, 189 zuc1openthixol, 188

Mental health enquiry (MHE), 3 Mismatch negativity, (MMN), 57 Milestones,

achievement of, 109, 111 of evolving disorder, 75 missed, in English

schoolchildren, 17

262

Mitochondrial function, 235, 236 Modular Present State Examination, 126 Motor disturbances, 149, 150,232 National Survey of Health and Development (NSHD), 2,3,4,18,23,25 NARSAD,65 N-methyl-D-aspartate (NMDA), 242-247 NMDA receptor hypofunction (NRH), 243-246 Negative psychopathology, 138 Negative symptoms, 75-87, 93,104, 113, 140, 142-145, 150, 152, 173, 181, 186-188,200,203,208,220,221,243, 244,247 Negative-symptom schizophrenia, 49 Negative syndrome, 86, 87 Neurocognitive variables, 109, III Neurodevelopmental

defects, 204 deficits, 221 mechanisms, 247 variables, 109, 110

Neurobiology, 118, 199,247 Neurochemistry, 192 Neurodegeneration, 168, 176,236,237, 240,245-247 Neurodegenerative

disorder, 235 hypothesis, 233, 245, 246

Neurodevelopmental hypothesis, 232, 246 Neuroendocrinology, 192 Neuroimaging, 47, 51, 56, 62,172,192 Neuroimaging examinations, 62, 109, 234

cortical serotonin receptors, 62 Functional Magentic

Resonance Imaging (FMRI), 62 Magnetic Resonance Imaging

(MRI), 57, 62, 234 Positron Emission

Tomography (PET), 57, 62

Neuroleptic medication, 108,113, 117, 151,152,184-187,189,191,192,213, 240,241 Neuroleptic response, 190 Neuroleptic therapy,

atypical, 117 Neuromotor parameters, 72 Neuron loss, 153 Neuronal cell death, 235-241, 245, 246 Neurophysiology, 56, 62 Neurophysiological examinations, 62

Mismatch negativity (MMN), 62 P300,62 Transcranial Magnetic

Stimulation-High Resolution EEG ,57, 62 Neuropsychological test battery, 62

California Verbal Learning Test (CVL T), 62

CPF,62 CPF-Delay,62 Distraction, 62 Verbal Fluency Test, 62 WAIS-R,62

Neuropsychology, 47, 50, 56, 61, 62, 72 New York High Risk Project, 35, 72,105 NIMH,42 NMDA hypothesis, 114 Non-paranoid schizophrenics, 36 Non-specific symptoms, 75-80, 104 OB Copenhagen High Risk Project, 40 Obsessive-compulsive disorder, 65, 128 Olanzapine, 156, 170-172, 189,223, 244 Oxidative stress, 237, 239, 240, 245, 246 Panic,149 Pan-neurosis, 48 Past History and Sociodemographic Description Schedule (PHSD), 75 Paranoia, 137, 139, 143,201,243 Paranoid delusions, 80 Paranoid Personality Disorder, 63, 182 Paranoid schizophrenics, 35,36

Perceptual abberation scale, 51 Perceptual abnormalities, 137 Perinatal complications, 109 Perinatal damage, 49 Peripsychosis, 1, 12, 25 Perphenazine, 156, 188, 189 Personal Assessment and Crisis Evaluation (PACE) Clinic, 103-105, 109,110,115-117,213,214 Personality Disorder Questionnaire (PDQ), 61, 63-65 Pharmacotherapy, 167, 169, 181 Phenothiazine, 184 Phenotype, 235 Placebo treatment

medication, 117 psychological, 117

Positive and Negative Symptom Scale (P~SS),61,63,65, 138, 155, 158-160,162,170,173 Positive symptoms, 75-83, 86, 93, 104, 137,138, 140, 142, 143, 150, 152, 168, 173,200,214,221 Positive -symptom schizophrenia, 49 Positron Emission Tomography (PET), 57,62,172-174,189 Posner-test, 51, 62 Post-psychotic phase, 114 Precursors of schizophrenia

behavioral, 33 CNS deviances, 52 dispositional, 33,34 impaired social behavior, 89

Prediction models, 18,35,41,93 Predictors,

adolescent, 2 childhood, 2 depression, 86 depressive symptoms, 84 developmental, 2 early illness, 76, 77,83 hippocampal volume, 110 neuroimaging examinations, 57

neuropsychological examinations, 57, 61, 62

neourophysiological examinations, 57

of psychosis, 109 poor affective control, 49

Premonitory symptoms, 74

263

Premorbid Adjustment Scale (PAS), 61, 63,64,65,75,125,160 Premorbid functioning, 118 Premorbid indicators, 33,34,36,39,40, 49,74, 151, 152 Prepsychotic, 21,25, 53, 58,101-103, 114, 115, 118, 151, 153,208,224 Preschizophrenic, 33, 35, 37-39,50,51

boys, 34, 48,49 girls, 35, 48,49

Present state examination (PSE) 3,4, 30, 75,93,125,129

modular, 126 Prevention paradox, 22 Preventive intervention, 57,103,117 Primary care, 53, 125, 131, 153, 158, 214 Primary personality disorders, 130 PROD, 58, 59, 63, 60, 61, 62, 63, 64 Prodromal change model, 55 Prodromal constellations, 135 Prodromal phase, 52, 71, 74-77, 80, 86-89,94,95,101,104,106,114,151, 153,197-201,203,206,208,212,215, 216,224

intervention during, 52, 136, 198 length of, 52 stigma during, 201, 202, 210

Prodromal psychosis, 197,205 Prodromal Signs Checklist, 126 Prodromal state, 118, 126, 132, 136-141,151,202,214,218,220,224 Prodromal symptoms, 47, 52, 53, 57, 58,61,63,64,65,71,74,75,96,125, 132,136,137,151,153,158,198,204, 209,217,222

264

Prodromal treatment, 136 Prodrome of psychosis, 52, 53, 55, 74, 104-106,113,118,168,176

basic symptoms in, 54 behavioral changes, 53, 54, 56 initial, 53 hyperfunction in, 53 hypofUnction in, 53 intervention during, 169 reactive symptoms, 56 relapse, 53 attention defects in, 54

Program of Assertive Community Treatment (PACT), 224 Pseudoneurotic schizophrenia, 48 Pseudopsychotic,35 Psychiatric morbidity, 132 Psychiatric and Personal History Schedule (PPHS), 75 Psychoeducation, 208, 212 Psychoeducational model, 216 Psychoeducational Multi-family Group (PE~G),211,214,216,220,223,224

Psychological Impairments Rating Schedule (PIRS), 75, 93 Psychological treatment, 117 Psychopathology, 138

disorganized, 138 general, 138 negative, 138

Psychosis threshold, 137 Psychosocial

disorders, 130, 204 fUnction, 233 intervention, 224 stress, 199 treatments, 115, 117,204,214, 224

Psychotic break, 140 Psychotic disorder, 63,101,131,162, 197,199,200,210,215,217,218,224 Psychotic episode, 71-75, 77-80, 84, 85, 108,220,223,246 Psychotic prephase, 76, 77

Psychotic phase, 153 Psychotic state, 135, 136, 198 Psychotic symptoms, 71-75, 79,86,93-96,109,158,168,169,197,205,217, 223

genetic vulnerability to, 51 thought disorder, 80, 81,137, 182,223

Psychotogenic lysergic acid (LSD), 191, 243 Psychotomimetic effect, 244-246 Quality of Life Scale (QLS), 61, 63, 64 Quantitative EEG (QEEG), 57 Quetiapine, 172, 175, 223 Rearing enivironment, 34,36-38,41,49 Risk factors,

state, 109 trait, 109

Risperidone, 116, 156, 170-173, 186, 188, 189 Rivermead behavioral memory test, 50 ROC models, 15,23 Role functioning,

deterioration in, 147, 150,206 Scale for the Assessment of Negative Symptoms (SANS), 75, 85, 86, 93, 109 Schizoaffective disorder, 155, 182 Schizophrenic outcome, 31, 35 Schizophrenic predisposition, 32, 34 Schizophreniform disorder, 190 Schizotypal personality disorders, 48, 106, 107, 138, 139, 155, 181 School behavior, 37,38,40,41 Scale of Prodromal Symptoms (SOPS), 135-142,150 scm, 61, 63, 64,160 Serotonin-dopamine antagonists, 187, 189 Serotonin receptors, changes in, 57 Sexual dysfunction, 130 Single Proton Emission Topography (SPECT), 172, 174 Sleep disturbance, 148, 150 Social course, 91-93 Social

adjustment, 160

disability, 75, 87, 93, 95, 96, 128 decline, 88,94, 168 disadvantage, 88, 89 isolation, 199,202,203,220 network, 210, 220 overadaptiveness, 93 role performance, 89-95 stagnation, 88, 94 withdrawal, 79, 80, 87,145, 204,206,215,243

Social morbidity, 129 Social Stagnation Hypothesis, 88 Socially adverse behavior, 93, 94 Somatization, 130 Stadium melancholicum, 86 Standard treatment protocol, 156, 159 Stepwise regression, 9,24, 93 Stress-vulnerability model, 118 Structural Interview for Prodromal Symptoms (SIPS), 58-61, 63-65, 135-139,141 Substance abuse, 93, 95, 96, 125, 130, 160,168,198,201,215 Subthreshold syndrome, 103, 105 Suicide

attempted, 81, 82 risk of, 82 thoughts of, 149

Suicide risk checklist, 126 Superoxide dismutase (SOD), 238, 240, 246 Symptom Check List (SCL), 61, 63, 65 Tardive Dyskinesia (TD), 171, 176, 185,241 Teacher questionnaire, 4

analysis, 5, 10 milestones, 5 results, 6

Teacher reports, Schoolchildren, characteristics of, 7 categorical data, 12 combined developmental

aspects of risk, 17

265

Thiobarbituric acid reactive substances (TBARS),241 Thought disorder, 80, 81,137, 182,223 Timid daydreamers, 54

as high-risk group, 21 as predictors of schizophrenia, 21,54

TIPS Project, 151, 154-157, 163, 164 Thioridazine, 189 Trait criteria, 72 Transition to psychosis, 110,113,116 Treatments,

biological, 115 medical, 117 psychological, 117 psychosocial, 115,117,204, 214,224

Transcranial Magnetic Stimulation­High Resolution EEG (TMS-HR-EEG), 57,62 Twin studies, 231 Ultra high-risk group, 105, 109, 110, 113, 114, 116, 118 Untreated psychosis, 71, 72 Withdrawal, 139, 145, 150,243 Working memory, difficulty in, 51 World Health Organization (WHO), 43, 203 Zuclopenthixol, 188

Name Index

Abdalla, D.S., 250

Achiron, A., 249

Ackenheil. M., 249

Adamo, V.H., 120

Adams, B., 251

Adams, M.E., 180

Addington, D., 99

Addington, J., 99

Adlard, S., 121,122,178

Adler, L.E., 250, 251

Agarwal, S., 249

Alanen,Y.O., 47,48, 65

Allebeck, P., 28, 248

Allen, A.J., 249

Alliger, R., 247

Alpert, M., 88,99

Altamura, 186,193

Alvir, J.M.I., 44, 68, 97, 119, 165, 177,

179,180,248,249

Amano, M., 251

Ameli, R., 67

Amico, E., 251

Amin, S.,66

Amsler, 185,193

Anand, A., 251

an der Heiden. W., 96-100.119,120.

177

Anderson, C.M., 133, 216, 228, 230

Anderson, Y., 66

Andreasen, N.C., 98, 120, 177, 247

Andrews, P.I., 249

267

Anis, N.A., 250

Annable, L., i178

Anwyl, R., 250

Arancio, 0., 250

Arean, P., 228

Arenal, A., 100

Arndt, S., 120, 177,248

Aronen, H.J., 67

Asensi, M., 251

Asnis,L., 65

Atkins, E., 26

Aubrey, A., 44, 98

Auerbach, J.G., 44, 98

Ayd, F.I., 193

Baker, R.W., 178

Ba1dessarini, R.I., 173,179

Balter, M.B., 133

Baron, 48, 68, 65

Barr, C.E., 43, 44

Barrowclough, c., 133

Barouche, F., 179, 195

Bartko, G., 180

Bassett, A.S., 97, 120

Batinic-Haberle, I., 250

Baucom, D.H., 229

Baum, K.M., 50, 65

Bauer-Schubart, C., 98

Beasley, C., Jr., 178, 195

Bean, G., 179

Beau, M.M., 249

Bebbington, P., 119, 201,226,228

268

Bechara, E.J., 250

Beck, A.T., 126, 127,133

Becker, T., 227

Bedford, A., 82,86,99

Bedwell, J., 119,249

Bell,M.,44

Bell, R.Q., 120

Bell, W.R., 250

Bellack, A.S., 134

Beiser,M., 53, 65, 67, 97,152,165, 179

Benes, F.M., 179

Bennett, J., 180

Bergman, H., 227

Bergman, J., 67

Berisford, M.A., 178

Berkovic, S.F., 249

Berkowitz, R., 134

Berman, R.M., 251

Berner, W.,l00

Berry, S.C., 250

Bertha, E., 193

Betz, N .E., 44

Bickford, P., 250

Biegel, D.E., 228

Biehl, H., 98, 99

Bigelow, L.B., 177

Bilder, R.,l00, 177.180

Bilker, W., 248

Birchwood, M., 99. 119, 165,225

Birley, J.L.T., 226

Bittigau, P., 251

Blanchard, J.e., 250

Blazer,D., 132

Bleuler,47

Blumenthal, J., 119,249

Blyler, e.R., 227

Bockaert, J., 250

Bohme, G.A., 250

Boix, J., 251

Bollini, P., 180

Bon, C., 250

Bonnet, D., 43

Borenstein, M., 177. 248

Borg, D.C., 249

Borges, K., 250

Borison, R.L., 194

Bosch, F., 251

Bowers, M.B., 250

Bowie, D., 250

Boyd,J., 230

Brammer M., 121

Brandt, L., 28

Brar, J.S., 249

Brauzer, B.,180

Bravin, J., 122, 178

Brecher, M., 178

Bredt, D.S., 250

Breier, A., 187,193,250,251

Bremmer, J.D., 250

Brewer, W., 66,121

Brewin, C., 226

Bridle, N.,121

Brodie, J.D., 179

Bromet, E.J., 99, 178, 227

Brooks, V.G., 178

Brown, A.e., 133

Brown, B.S., 133,

Brown, G.W., 201, 226-228

Brugha, T.S., 178, 228

Bryne, M., 66

Bubeck, B., 180

Buchanan,R.W., 187,193

Buckley, P.F., 121, 248

Buka, S.L., 26

Bullmore, E.T., 121, 177

Burke, J.D., 133

Burks, E., 178

Burman, B., 43

Burman, M.A., 132

Bums, BJ., 133

Burrows, G.D., 68

Burton, N.R., 250

Bustamante, S., 97

Buzina, R., 250

Byrd, S.L., 179

Cadet, J .L., 249

Caligiuri, M.P., 178

Cameron, D.E., 53, 66

Campbell, G., 250

Cannon, M., 26, 248, 249

Cannon, T.D., 41,43,44,48,51,52,66,

68,97,248

Cantor-Graae, E., 121

Cappiello, A., 251

Capri, S.,225

Cardenas, e., 178

Cardno, A.G., 248

Carlen, P.L., 251

Carlson, G., 178

Carlsson, A., 251

Carlsson,M.L., 251

Carman,J., 188,193

Carpenter, W.T., 127,134,160,165,

187,193

Carter, J.W., 29,44

Casey, D.E., 178, 180,184,193

Castle, DJ., 248

Cauley, K., 249

Cerri, A., 66

Chafetz, L., 228

Chakos, M., 177, 179, 180,248,249,

251

Chalmers, T.e., 180

Chapman, J.P., 54, 66,136, 141

Chapman, L.J., 141

Chapman, P.F., 250

Charbonneau-Powis, M., 134

Charney, D.S., 250, 251

Chengappa, K.N.R., 178,249

Cherry, N., 26

Choquet,M., l00

Chouinard, G., 178

Christensen, B.K., 180

Christensen, J., 249

269

270

Christie, S., 179

Chuang, D.M., 249

Chung, L.c., 251

Cicchetti, D., 225

Clark, D.H., 53, 66

Clement, M.V., 251

Clements, B.A., 66

Clifton, A., 251

Coakley, G., 177

Cocharne, 165

Cohen, B,M., 179

Cohen, C.I., 227

Coid, B., 248

Cole, D., 178

Cole, J.M., 184,193

Collins, P.F., 193

Condray, R., 226

Conrad, K., 99

Cook, M., 121

Cooper, J.E., 27, 98, 133

Cooper, T.B., 179, 195

Copolov, D., 66,121

Coppens, H.J., 179

Comblatt, B.A., 44, 97, 120

Correnti, E.E., 250

Cotton, P., 179

Cosgrave, E.M., 122, 178

Coverdale, J.H., i166

Cowell, P., 248

Cox, 109 (???)

Coyle, J.T., 250,251

Craig, T., 178

Crain, B., 249

Crapo, J.D., 250, 251

Creese, I., 180

Croudace, T.J., 1

Crow, TJ., 26,44, 68, 72,97,119,

133,152,165,225

Crump, N.H., 121

Cuesta Nunez, M.J., 100

Cu1casi, M., 250

Cullen, F.T., 226

Curti, D., 249

Czobor, P., 194, 195

D' Adamio, L., 249

Dalais, c., 44

Daly, D., 251

Dahlqvist, R., 179

Das, I., 250

Das, M.K., 228

Das Gupta, F., 249

DaSilva, J., 179

Daskalakis, Z.J., 179

David, A.S., 28, 121, 248

Davidson, L., 135

Davidson, M., 193

Davies, N.J., 248

Davis, J.M., 180, 184, 191,193

Davis, K.L., 193

Davis, W.W., 120

Dawson, T.M., 250

Dawson, V.L., 250

Day, BJ., 250, 251

Deakins, M.D., 166, 230

De Koninck, 252

Delaney, R., 250

De la Varga, M., 100

DeLisi, L.E., 100,248

Demisch, S., 180

Depue,R.A., 183,193

Deshimaru, M., 250

De Smedt, G., il78

Desmond, P., 121

Dichter, M.A., 249

Dikranian, K., 251

Dilling, H., 133

Dingledine, R., 250

Dixon, WJ., 194,248

Doble, A., 250

Dobscha, S., 57, 67

Docherty, J.P., 82, 86,99

Doddi, S., 194

Domesick, V.B., 180

Done, DJ., 26, 98

Doneshka, P., 67

Dopfner, M., 100

Doraiswamy, P.M., 179

Doran, A.R., 193

Douglas, J.W.B., 26, 27

Dow, S.,249

Dozier,M., 203,227

Draine, J., 227, 228

Dubbert, B.K., 249

Duckworth, K., 226

Dudgeon, P., 98, 121, 177

Duncan, G., 251

Dunham, H.W., 86,99

Dunn, L., 179

Dunne, E., 225

Durrell,J., 203,228

Dwork, A.J., 249

Dyck, D., 226

Eaton, W.W., 120

Eberlein-Vries, R., 134

271

Edwards, J., 26,97,119,133,154,166,

216,230

Ehrin, E., 179

Ekstrom, M., 44

Elman, I., 251

Emory, E., 43

Emsley, R., 178

Endicott, J., 165

English, C.W., 178

Ensel, W., 227

Erbas, T., 179

Erhart, S.M., 179

Erickson, D., 65, 97, 165

Erlenmeyer-Kimling, L., 44, 97, 120

Ermilov, M., 251

Eronen, E., 67

Escobar, J.L., 132

Espinosa, R., 249

Evans, A., 119,249

Fadden, G., 133

272

Falkai, P., 97

Falloon, I.R.H., 41,44,99,122, 123,

125-127,131,133,134,153,154,158,

164,166,211-213,224,229,230

Farber, J.L., 250, 251

Farde, L., 179, 189,193

Farkenheuer, B., 67, 98, 100, 120

Farmer, A.E., 248

Fegert, J.M., 100

Feinberg, J., 57, 66

Feldman, P.M., 44

Fennig, S., 99, 178

Fenton, W.S., 95,100,225,227

Ferrier, I.N., 249

Fertig,M.K., 178

Fernandez, T., 119, 249

Fibiger,H.C., 189,193

Fikuda, M., 68

Fischer, I.A., 248

Fish, B., 97

Fiszbein, A., 142, 166

Fix, A.S., 251

Flach, K., 250

Flaum, M., 120, 177, 247

Fleming, J.A.E., 65, 97, 165

Flynn, S.W., 97

Florijn, W.j., 180

Foerster, A., 119

Fog, R., 165, 178

Folnegovic, V., 250

Folstein,M.F., 133

Folstein, S.E, 133

Forslund, K., 179

Forster,MJ.,249

Foulds, G.A., 82,86,99

Fowler, J.S., 179

Frazier, J.A., 248

Francey, S., 66, 97, 121,122, 178

Frangou, S., 177

Frank, E., 229

Franke, P., 66

Frantseva, M.V., 251

Freedman, R., 250

Freeman, G.K., 250

Freeman, H.,88,99

Frenkel, E., 44

Fridovich, I., 251

Friedman, D., 97

Friis, S., 151

Friston, K.J., 194

Frith, C.D., 194

Frumin, M., 248

Fujino, H., 251

Fukuda, J., 251

Fuller, M.A., 179

Gahring, L.C., 249

Gaite, L., 100

Gallacher, F., 248

Gallo,JJ., 182,194

Ganguli, R., 249

Garcia de la Asuncion, J., 251

Gardner, C.O., 248

Gamer, 126

Garratt, L.S., 225

Garrison, V., 227

Garver, D.L., 180,184,193,194,249

Garvey, M., 249

Geddes, J.R, 44,180

Geider, F.J., 180

Geisler, S.H., 44, 68,97,100, 119, 166,

177,180,248,249

George, E.L., 229

George, L.K., 132

Gerlach, 1., 178, 186,193

Germano, D., 122, 178

Gershon, S., 180

Giedd, J.N., 119, 248, 249

Giel, R., 248

Gierl, B., 180

Gillham, J., 120

Gispen-de Wied, c.c., 248

Gliddon, A., 250

Glover, G., 248

Goff, D.C., 251

Gold, J.M., 50, 66

Goldberg, D., 133

Goldberg, S.C., 187,193

Goldberg, T.E., 50, 66,100,177

Goldman, C., 226

Goldman, H.H., 165

Goldman, R., 180

Goldman-Rakic, P.S., 248

Goldstein, D., 178, , 201, 211

Goldstein, J.M., 26.127,134

Goldstein, M., 226, 229, 230

Gonzalez, S.P., 217, 230

Gordon, C.T., 248

Gorham, D.R., 121,138, 142

Gottesman, 1.1., 43,120,248

Graham, D.G., 250

Graham-Hole, V., 134

Grant, E., 66

Grayson, D.S., 27

Grebb,185,193,194

Green, M.F., 165, 177,248

Griesinger, W., 86,99

Griffith, J., 180, 250

Grimson, R, 248

Grochowski, S., 67

273

Gross,G., 54, 58, 66,67, 68, 97, 98, 141,

165,177,248

Grove, W.M., 66

Gruber, R., 249

Gruen, R., 65

Gruenberg, A.M., 67

Grundy, S., i178

Gruzelier, J.H., 69

Grubb, T.W.

Gupta, S., 177

Gur, R, 66, 248

Gutknecht, W.F., 250

Gutkind, D., 44

Guvener, N., 179

Guy, W., 133

274

Guyatt, G.H., 27

Gwag, B.J., 251

Haaparanta, M., 67

Haas, G.L., 152,165,177, 198,225

Hafner H., 53, 58, 65, 66, 67, 71,96-

100,119,120,136,141 ,152,165,177,

247

Hagg, S., 179

Haggerty, R.J., 28, 120

Hain, c., 66

Haley, J.E., 250

Hall, H., 179

Halldin, C., 179

Hallgren, M.A., 121,122,178

Hambrecht, M., 67, 96, 98, 99, 120

Hamburger, S., 119, 248,249

Hamilton, M.,126, 133

Hamilton, N.G., 227

Hammett, E.B. 179

Hans, S.L., 44, 98

Hansen, V., 179

Hanslick, J., 251

Hansson, L.O., 251

Harcherik, D., 67

Hardt, J., 66

Hardy, J., 120

Hare, E.H., 248

Hargreaves, R.J., 251

Harikainen, A.L., 26, 98

Harrigan, S.M., 26, 97, 119, 133, 166

Harris, J.G., 250

Harris, M.J., 178,227

Harris, T., 227

Harrison, G., 66

Harrison, P.J., 248

Harrow, M., 99

Harvey, I., 121, 190

Harvey, P.D., 193

Hasegawa, M., 251

Haslam, N., 43

Hassan, M., 180

Havassy, B., 228

Hawkins, R.D., 250

Hayashida, S., 68

Hayden, D.L., 251

Haynes, R.B., 27

Hays, J.C., 228

He, X.P., 249

Helgason, L., 72, 97, 165,225

Heller, T., 227

Hearn, N., 122, 178

Heinemann, S.F., 249

Heinimaa, 141

Heinrichs, D.W., 127,134, 187,193

Heinssen, R.K., 227

Hemsley, D.R., 177

Henderson, A.S., 27

Heninger, G.R., 250

Heresco-Levy, U., 251

Herczeg, I., 180

Herrera Castanedo, S.,l00

Hersen, M., 134

Herz,126

Heston, L.L., 43

Hetts, S., 249

Hietala, 52,67

Hijman, R., 251

Hilder, W., 25

Hill, R.G., 251

Himmelhoch, J.M., 134

Hirayasu, Y., 248

Hirsch, S.R., 66, 69, 228, 250

Hirschowitz, J., 180

Hiramatsu, K-I., 68

Hoch, P.H., 48,67

Hodges, A., 66

Hoff, A.L., 100, 248

Hoffman, R.E., 67,135

Hogarty, G.E.,126, 127,133,180,194,

216,226, 229,230

Hollis, c., 48, 67

Hollister, J.M.,26, 43, 248

Hommer, D.W., 195

Honer, W.G., 97

Honigfeld, G., 194

Hooley, J.M., 226

Hoppes, E., 43

Hora ek, J., 194 (please verify spelling

on this one; it appears this way 2x)

Homeland, M., 151

Hough, R.L., 132

Houle, S., 179, 180

Hoult, J.,127, 134

Howard, R.J., 121

Hoyos, c., 121

Hubbard, W.c., 177

275

Huber, G., 54, 58,66, 67, 68, 72,96, 97,

98,109,141,151,165,248

Hughes, T.E., 249

Hulbert, 216

Hultman, C.M., 227, 228

Hurd, G., 227

Husby, R.,142

Huttenlocher, P.R., 57, 67

Huttunen, M.O., 25,26,43,66,187,

193, 248, 248

Huttunen, T., 26, 248

Huxley, P., 133

Hwu, H.G., 227

Hyde, A., 226

Hyde, T.M., 100, 177

Iacono, W.G., 65,66, 67, 97

Ikeda, K., 251

Ikeda, M., 251

Ikonomidou, c., 251

Ilmonieni, 57, 67

Ingraham, LJ., 44

Inoue, K., 165

Iqbal,N., 191 , 193

Ismail, B., 121

Isohanni, H., 98

Isohanni, M., 26

Iversen, L.L., 251

Iwasaki, K., 249

276

Izumi, Y., 250

Jablensky, A., 98

Jacobsen, B., 43,68,97

Jackson, D., 99

Jackson, HJ., 26,74,97,98,119-121,

133,166,177,216,230

Jacobsen, L., 248

Jane, J.L., 179

Janicak,P.G., 186,193

Janssen, P.M.F., 194

Janumpalli, S., 249

Jarvelin, M.R., 26

Jaskiw, G.E.,179, 248

Javaid, J.I.,193

Javitt, D.C., 250, 251

Jaycox, L.H., 120

Javitt,D.C., 52, 67

Jeffries, N.,l19, 249

Jeste, D.Y., 178

Jetovic-Todorovic, Y., 251

Joa,I.,151

Jody, D., 177, 248

Joelsson, L., 179

Johanessen, J.O., 119,136, 141,151,

153,164,165,166

John, R.S., 37,44, 68

Johnson, A.L., 44, 97, 119, 133, 165,

188

Johnson, D.A.W.,193, 227, 229

Johnstone, E.C., 26, 44, 66, 9,119,152,

165,180,225

Jokelainen, J., 26

Jones,C.,179,180,194

Jones, F., 66

Jones, K., 133

Jones, L.A., 248

Jones, P.B., 1,2,11,18,26,54,67,74,98,

119,121,177,248,249

Jones, S., 249

Jorgensen, A., 179

Jung, E., 98, 99

Jurjus, G.J., 179

Juul Povlsen, U.,178

Kahler, L.A., 249

Kahn,R.S, 191,193,248,251

Kajiwara, K., 251

Kaleva, M., 69

Kaljonen, I.H.A., 100

Kallmann, FJ., 43

Kamerow, D.B., 133

Kameyama, K., 68, 251

Kamoshita, S., 27

Karnran, A., 179

Kandel, E.R., 250

Kane, lM., 65, 127,134,165,176,178-

180,185,186,194,225

Kaplan, 185, 194

Kapur,S, 167,178-180, 186, 189,194

Karajgi, B., 194

Karayiorgu, M., 249

Karhu, J.,67

Karper, L.P., 250

Karr, M.l80

Katila, T., 67

Kato, N., 165

Katsanis, J., 66, 67

Katz, B., 179

Kaufman, M.A., 249

Kawachi, I., 227

Kay, D.W.K., 27

Kay, S.R., 138,142,166

Kaysen, D., 248

Keith, S.J., 211, 225, 248

Keitner, G.I., 230

Kelkar, H., 250

Kendler,H.S., 47, 48, 67, 68, 228, 248

Keshavan, S., 165

Kestenbaum, CJ., 120

Kiernan, K.E., 26

Kim, E.Y., 251

Kim, Y.H. 251

Kind, P., 133

Kingsbury, S.J., 249

Kinon, BJ., 251

Kinoshita, H., 251

Kinsella, A., 177

Kirby, e., 251

Kirch, D.G., 249

Kirkpatrick, B., 193

Kirvela, 0., 67

Kishida, E., 251

Kissling, W., 180

Kleinman, J.E., 100, 177

Klerman, G.L., 193

Klosterkotter,J., 51, 54, 58, 66, 68,

72,74,82,96,97,98,99,136,141

KO,G., 193

Kodama, H., 251

Koffel, B., 250

Koh, J.Y., 251

Kohr, G., 251

Kojo, Y., 251

Konicki, P.E., 179

Kopala, L.e., 97

Kopeikin, H., 230

Korbar, M., 250

277

Koreen, A.R., 166, 177, 179, 180,249

Koren, D., 26

Korf, J., 179

Kosky, R., 120

Kostakoglu, A.E., 170

Kostic, V., 249

Kottgen, C., 229

Koval, M.S., 179

Kovasznay, B., 178

Kraepelin, E., 47, 71, 82,96, 99, 151,

165,192

Kraude, W.H., 248

Kraus, J., 231, 249, 251,252

Krausz, M., 119

Krekorian, H., 122

Kreitshmann-Adermahr, I., 68

Kremen, W.S., 26

Kristbjarnarson, H., 249

278

Krumm, B., 98, 99

Krystal, J.H., 250, 251

Ku, H.H., 249

Kubota, A., 251

Kugelmass, S., 44

Kuipers, L., 134,201,226

Kulhara, P.L., 228

Kulkarni, 1., 230

Kumagai, J., 251

Kumar, N.G., 249

Kumra, S., 248

Kuoppamaki, M., 67

Kushner, M., 248

Kvebrek, R., 151

Kwapil, T.R., 141

Kysar, L., 178

Labruyere, J., 251

Lacana, E., 249

Lacro, J.P., 178

Lafton-Cazal, M., 250

Lahti, I., 69, 250

Laing, P., 43, 248

Laksy, K., 69

Lal,H.,249

Landerman, R., 132

Lange, N., 251

Lapointe, 1.S., 97

Laporta, M., 122

LaPorte, D., 250

Larsen, T.K.,141, 151, 152,166

Lavelle, J., 178

Lavori, P., 250

Lawrie, S.M., 44

Lebow, B.S., 66

Ledoux, S., 100

Lee, J.C., 194

Leff,J., 126,134,211,226,228,229

Letley, H.P., 227, 229

Lehman, A.F., 160,165,166,225,229

Lehmkuhl, G., 100

Lehmkuhl, U., 100

Leinonen,E., 68

Lemmens, P., 178

LeMoal, 183,194

Lenane, M., 119, 248, 249

Lenz, K., 100, 178

Leonard, H.L., 249

Leonard, S., 250

Lesage, A., 178

Levine, J., 229

Levinson, D.F., 249

Levitt, J.J., 248, 251

Lewine, R.J., 50, 69, 97

Lewis, D.A., 248

Lewis, G., 26,28, 248

Lewis, S.W., 119,248

Leysen,J.E., 189,194

Liberman, R.P., 133, 152

Lieberman, J.A., 44,68,97,100, 119,

127,153,165,166,177-180,225,132,

248,249,251

Libiger, J., 181,194

Licht, D.M., 226

Lichtenstein, M., 251

Liddle, P.F., 51,68,191,194

Lin,N., 227

Lin, S.P., 248

Lincoln, c., 154, 166

Lindelius, R., 97

Lindstroem,L.H., 185,194

Link,B.G., 201, 226, 227

Linz, M., 66, 67, 97, 248

Lipschutz-Broch, L., 100

Lipsitt, L.P., 26

Lipska, B.K., 177, 248

Lipton, F., 228

Livingston, M., 178

Llama, R., 227

Lo, T., 152,165

Lo, W.H., 152,165

Lodge, D., 250

Loebel, A.D., 44,53,68, 72,97, 119,152,

165,177,179,225,248

Loeffler, W., 67, 96, 97, 98, 99, 119,

120, 141,165

Lohr, J.B. 250

London, E.D., 250

Lonnqvist, J., 66

Lord, A., 65

Lougee, L., 249

Lublin, H., 178

Lukens, E.P., 226, 229

MacDonald, A., 122,178, 248

MacDonald, D.I., 133

MacDonald, E.M., 227, 250

Machon, R.A., 43, 248

Mackie, M., 179

279

MacMillan, J.F., 44, 97,119,133,165,

226

Madison, D.V., 250

Magliano, L., 134

Mahadik, J.S., 250,

Mahadik, S.P., 249, 250, 251

Mahtani, M.M., 249

Maier, W.,66

Mailman, R.B., 251

Malas, K.L., 195

Malhotra, A.K., 250, 251

Malkoff Schwartz, S., 228

Malmberg, A., 28, 248

Mann, S.A., 27

Mannisto, P., 195

Manoach, D., 251

March, J.S., 249

Marchbanks, R.M., 249

Marcus, J., 44,98

Mardal, S., 151

Marder, S.R., 99,127,178-180,187,

194

Marengo, J.T., 99

Marks, I.M.,127, 134

Marmot, M., 26, 67, 98

Marshall, EJ., 248

Marshall, V., 230

280

Martin, D., 251

Masuzawa, Y., 251

Mathis, C., 250

Matsubara, S., 194

Maurer,K., 53, 66,67, 71,96,97,98,99,

119,120,141,165

May,P.R.A., 185,194,248

Mayerhoff, D.I., 44, 68,97, 100,

119,177.180,248

Maylath, E., 180

McCarley, R.W., 248, 251

McCready, R., 178, 179,250

McDermott,B.E., 190,194

McElhinny, L.G., 250

McEvoy, J.P., 180, 186,194

McFarlane, C.A., 97, 120-122,154,229

McFarlane, W., 166,197,225,226,230

McGill, c., 230 McGlashan, T.H., 21, 52,57, 58, 59, 61,67,68,95,100,119,135, 136, 141,151,153,164,165,166,225

McGorry, P.D., 21, 26, 53-58, 66, 68, 69, 72,74,97, 98,101, 119-122, 133,135,142, 153, 158,166,177,178, 206,213,216,224,229,230

McGrath, l.1.,121

McGuffin, P., 248

McGuire,M., 67

McGuire, P.K., 121

McHugh, P.R, 133

McIntyre, I.M., 180

McKenna, K., 248

McLees, S., 122

McNamara, J.O., 249, 251,252

McNeil, T.F., 43,121

McQueen, L.E., 120

McWilliams, L., 251

Mears, A., 120

Medley, I., 66

Mednick, B., 44

Mednick, S.A., 21,26,29,37,42,43,44,

48,66,68,97,121,154,158,165,166,

248

Medus, c., 66

Meehl, P.E., 43

Meeks, S., 228

Meibach, R.C., 194

Meier, T., 69

Meissner, S., 67, 98,120

Melan, c., 250

Melle, 1.,151

Melson, A.K., 251

Meltzer,H.Y., 188,194

Melville, 126

Menzies, C., 179

Mercier, P., 178

Mestrovic, B., 250

Meurice, E.E., 51,68

Mihalopoulos, c., 26, 97, 119, 133, 166

Miklowitz,DJ., 127,134,227,229

Miksa, M., 251

Miller, A., 178

Miller, D., 247

Miller, I.W., 230

Miller, T.J., 135

Mingyuan, Z., 229

Mintz, J., 178

Mirotznik, J., 226

Mirsky, A.F., 44, 98

Missar, C.D., 250

Mittleman, B., 249

Miyakawa, T., 250

Mjorndal, T., 178

Mody, 1.,252

Moeller, H.J. 188, 194

Moghaddam, B., 251

Mohr,P., 182, 191,194

Moises, H.W., 249

Moldin, S.0.,35, 44, 249

Moller, P., 136, 142

Mompo, J., 251

Monteiro, H.P., 250

Mordel, c., 251

Moring, J., 69

Morita, H., 27

Morris, L., 100

Moscarelli, M., 151,165,225

Mossman, D., 27

Motlova, L., 194

Mrazek, P.J., 28,120

Mukhe~ee,S.,178,250,251

Mueller, H., 194

Mueser, K.T., 229

Mulier, H.J., 100

281

Muller, N., 100,249

Muller-Thomsen, T.S.O., 119

Munk-Jorgensen, P., 43,99,120,133,

178

Mumo, J.C., 177

Murata, M., 251

Murrie, V., 121

Murray, G., 248

Murray, R.M., 26,67,98,119, 121,

177,248

Murrell, S.A., 228

Muthen, B., 10, 27

Muthen, L., 27

Myers, J.K., 132

Nagler, S., 44, 98

Naarala, M., 69

Naatanen, R., 67

Nabeshima, T., 251

Nadler, J.V., 251, 252

Nagamoto, H., 250

Nair, T.R., 249

Nakajima, T., 165

Nakashima, Y., 179

Nancarrow, D.J., 249

Nara, Y., 251

Nasrallah, H.A., 69

Nathan, M. 44

Nawroz, S., 177

Negrete, S., 180

Nelson, J., 248

Neri, L., 225

282

Newcomer, I.W., 250, 251

Newton, M.R., 249

Nichols, D.E., 251

Nicolson, R., 119,249

Niemenen, P., 26

Nienhuis, F.I., 248

Niwa, S-I., 52, 68

Nordstrom, A.L., 179, 193

Noring, U., 178

Nowak, H., 69

Nowotny, B., 97, 99, 100, 119

Noy, S.,249

Nuechterlein, K.H., 228

Numano, F., 251

Nyberg, S., 179

Oakley-Browne, M., 133

O'Callaghan, E., 248, 251

O'Dell, T.J., 250

O'Donnell, D.W., 100

O'Hara, P., 178

O'Hare, A., 67

Ohman, A., 228

Oja, G., 179

Olarte, S., 178

Olin, S.S., 37,44, 48,68,97,154,

158,166

Olin, S.C., 121

Olincy, A., 250

Oliviera, I.A., 250

Olney, I.W., 250, 251

Opjordsmoen, S., 151, 152,165,166,

225

Opler, L.A., 142, 166

Oren, D.A., 251

Orza, M.J., 180

Ostrem, J.L., 177

Overall, J.E., 121,138, 141

Paans, A.M., 179

Pallanti, S., 228

Pallardo, F.V., 251

Palmer, B., 178

Pampallona, S., 180

Pantelis, c., 66,121

Pamas, J., 43, 44,48,66,68,97

Pashdag, I., 178

Paskevich, P.A., 180

Patel, M., 249, 250

Patten, S., 99

Paterson, J.R., 250

Pattison, E., 227

Pato, c., 178

Patton, G.c., 120-122, 178

Patton, S.G., 97

Pauli, S., 179

Paus, T., 119, 249

Paykel, E.S., 44

pazzagli, A., 228

Peacock, L., 178

Pearson, 88

Pederson, J., 229

Pedhazur, E.J., 43

Pelucio, M., 178

Penn, D.L., 229

Penninx, B.W., 227

Perez-Velazquez, J.L., 251

Perkins, D., 231

Perlick, D., 227

Perlmutter, S., 249

Pervaiz, S., 251

Peterson, G.A., 179

Peuskens,J., 187,193,194

Phelan, J., 178, 202,227

Phillips, L.J., 97, 101,121,122,178

Piantadosi, CA., 250

Pickar, D., 250, 251

Pietri, S., 250

Pinals, D.A., 250, 251

Pincus, H.A., 120,133

Pi-Sunyer, F.X., 178

Pluck, J., 100

Pogue-Geile, M.F., 99

Polatin, P.H., 48, 67

Poletti, A., 133

Popli, A.P., 179

Post, R.M., 225,226,249

Potvin, J.H., 178

Poustka, F., 100

Poutanen, V-P., 66

Praesthold, J., 44

Prehn, J.H., 251

Preskom, S.H., 193

Price, M.T., 251

Prien, R.F.,127,134

Prohovnik, I., 249

Purdon, S.E., 178

Putnam, K.M., 193

Quercioli, L., 228

Rabe-Hesketh, S., 26, 248

Rabin, B.S., 249

Rabiner, C.J.,152, 165,176,225

Rainer, J.D., 65

Rakkar, A., 97, 120

Rakkolainen, V., 67, 100

Rajapakse, J.C, 248

Ram, R., 178

Ramchand, CN., 250

Rames, L.J., 179

Randolph, E.T., 211, 229

Rantakallio, P., 26,98

Rapaport, J., 67, 119, 248, 249

Raphael, B., 68, 119

Reddy, R.D., 249, 250

Reerenhovi, L., 193

Reiger, D.A., 133

Reisby, N., 43

Reiss, D.J., 133,230

Reiter, G., 100

Rekola, J., 65

Reivich, K.J., 120

Remington, G., 167, 178-180, 194

Reveley, A.M., 248

Reynolds, I., 134

Ribchester, T.R., 228

283

284

Rich, C., 178

Richelson, E., 251

Rigby, M., 251

Riecher-Rossler,A., 67, 97, 98, 99,120

Riecher, A., 98

Riedel, M., 249

Rifkin,A., 186,194

Riordan, H., 100

Rishovd-Rund, B., 165

Ritter, W., 67

Roberts, S., 44, 120

Robins, E., 165

Robinson, D.G.,177,180, 248

Rock, D., 44, 120

Rockwell, E., 178

Rogers, S.W., 249

Rodgers, B., 26, 27, 67, 98

Rosberg, T., 68

Rose, Geoffrey, 22,28

Rosen, A.M., 178

Ross, J.M., 27

Ross-Chouinard, A., 178

Rossell, S., 121

Rosser, R.M., 133

Rotrosen, J., 179

Rubin, E., 250

Rubinstein, J., 178

Ruohonen, J., 67

Ruotsalainen, Y., 67

Rupp, A., 225

Rush, AJ., 133

Russell, A., 119, 177

Rutter, M., 27

Saarento, 0., 69

Sacker, A., 26, 28

Sackett, D.L., 27

Sadock, B., 194

Sagara, Y., 249

Saitoh, 0., 68

Sakuma, M., 248

Salokangas, R.K.R., 21,48, 52, 67, 69,

99,100,138

Salonen, 0., 66

Sanger, T.M., 178,195

Sarentakos, S., 134

Sartorius, N., 27, 98, 133

Sastre J., 251

Sauer, H., 180

Saugstad, L.F., 177

Saurer,H., 52, 68

Schaich, K.M., 249

Scheffer, R.E., 249, 250

Scherrer,S., 180

Schmeck, K., 100

Schmelkin, L.P., 43

Schmiedtke, A., 67, 98, 120

Schoenfeld, D.A., 251

Schoenfeld, P., 228

Schooler, N.R., 165, 180, 211,229,248

Schotte, A., 194

Schroder, J., 180

Schubart, c., 99

Schulsinger, F., 43, 44, 68, 97

Schulsinger, H., 43, 44, 68, 97

Schultze-Lutter, F., 68, 98, 141

Schuman, E.M., 250

Schuttler, R, 67,165

Schwartz, J.E., 99

Schwarz, MJ., 249

Scully, PJ., 177

Sedvall, G., 179

Seeman,M., 180

Seibyl, J.P., 250

Seidman, LJ., 26

Seitamaa. M., 69

Selemon, L.D., 248

Seligman, M.E., 120

Selke, G., 251

Selten, J.P., 248

Sesma, M.A., 251

Servan-Scbreiber, D., 67

Severe, J.B., 229

Sham, P.c., 119, 248

Shammi, C.M., 180

Shanahan, W.J., 122

Shapiro, RM., 177

Shapleske, J., 121

Sharma, R.P., 193

Shaw, B.F., 133

Sheitman, B., 177, 180, 248, 249

Shelton, P.S., 178

Shenton, M.E., 248

Shepherd, M., 99,133

Shields, J., 43

Shimizu, Y., 251

Shiue, C.Y., 179

Shuttler, R., 248

Simhandl, c., 178

Shona, M.F., 166

Shouldon, I., 249

Siever, L., 193

Sikich, L., 251

Silipo, G., 251

Silvestri, S., 180

Simon,H., 183,194

Simonsen, E., 151

Simpson, H.R, 27

Singer, J., 194

Singer, M., 227

Singh,B., 56,66, 68, 119, 121

Singh,S., 66

Sipila, P., 26, 98

Siris, S.G., 99

Sirocco, K., 250

Slooff, CJ., 179, 248

Smeeton, N., 99

Smith, A., 248

Smith, D., 251

Smith, G.N., 97

Smith, T.E., 194

Smythies, J.R., 250

Snyder, S.H., 250

Sohal, RS., 249

Sohn, S., 251

285

286

Sokolovsky, J., 227

Solgaard, T.,178

Solin,O.,67

Solomon, P., 227, 228

Sorri, A., 69

Squires-Wheeler, E., 97,120

Spellberg, BJ., 179

Spellman, M., 67

Spigset, 0., 179

Spitzer, R.L., 165

Spring, B., 226

Stamler, J.S., 250

Standerskold-Nordenstam, C-G., 66

Stastny, P., 230

Stefovska, Y., 251

Stein, L.I.,127, 133

Steinberg,H., 203,228

Steingard, S., 180, 194

Steinglass,P., 217, 230

Steinhauer, S.R., 69, 226

Steinmeyer, E.M., 68, 98,141

Steinwachs, D.M., 165, 166

Stengard, E., 99, 100

Stevens, K., 250

Stevens, J.R., 249

Stewen, A., 65

Stoffel, M., 249

Stone, C.K., 180

Strachan,A., 201, 226

Strauss, 160

Strong, D., 177

Stutzmann, J.M., 250

Suboticanec,K.,250

Sullivan, H.S., 102, 103,119,165

Sumiyoshi, S., 250

Suppes, T., 225

Susser, E.S., 248

Sutter, FJ., 194

Suzuki, M., 27

Suzuki, T., 250

Swedo, S.E., 249

Sweeney, J.A., 152,165, 177,225

Sylvalahti, E., 67

Szymanski, S.R., 44,68,97,119, 177,

248

Tagami, M., 251

Tallerico, T., 180

Talovic, S.A., 44

Takala, K., 65

Takei, N., 248

Takeuchi, D.T., 228

Tamminga, C.A., 250, 251

Tamura, R.N., 178

Tanabe, E., 251

Tanaka, T., 251

Tanskanen, A., 26, 248

Tarazi, F.I., 180

Tarrier, N.,127, 133, 229

Tatetsu, S., 250

Taylor, c., 249

Teasdale, T.W., 43, 44, 68

Teicher, M.H., 179

Tenkova, T.!., 251

Tenner, A., 249

Terry, W.M., 249

Test, M.A.,127, 133

Tew, W.,248

Thau, K., 178,182,194

Thiele, D.A., 248

Thompson, M.A., 252

Tien,A.Y., 182,194

Tienari, P., 44, 48,50, 69

Tierney, P., 121

Tiffany, S.M., 250

Tischler, G.L., 132

Tizard, J., 27

Todd, P.,99

Tohen, M., 178

Tokumaru, S., 251

Tollefson, G.D., 178,188,195

Tolsdorf, C., 228

Tomonari, H., 250

Tomov, T., 98

Toone, B.K., 119

Tran, P.V., 178

Traynelis, S.F., 250

Tsai, G., 251

Tsuang, M.T., 26

Tucker, D., 225

Tugwell, P., 27

Tuma, A.H., 177,194,248

Tuomisto,l., 191,195

Tuovinen, M., 65

Turetsky, B.I., 248

Turski, L., 251

Tyrka, A.R., 42

Ulrich, R., 229

Umbricht, D., 178

Uppfeldt, G., 179

Vaalburg, W., 179

Vaglum, P., 120,151

Vaituzis, A.C., 248

Valanne, L., 66

Van Berckel, B., 251

Van der Graaf, Y., 248

an der Heiden, W., 96-100, 119,120

Vander Heiden, W.,67

Van der Linden, J.A., 251

Van Dusen, K., 44

van Duursen, R., 248

Vanelle, J.M., 187,195

van Erp, T.G.M., 66

Vangeneugden A., 193

287

van Kammen, D.P., 99,187,195,250

Van as, J., 2,26,121,228,248

Van Praag, H., 193

van Ree, J.M., 251

Varia, V., 178

Vaughn, C., 133, 226

Vazquez-Barquero, J.L., 100

Velakoulis, D., 66,121

Venables, P.H., 44, 52, 69

Venturi, P., 248

Verma, A., 251

288

Verma, S.K., 228

Vestergaard, A., 44

Vilkman, H., 67

Vina, J., 251

Vina, J.R., 251

Vito, P., 249

Volavka,1., 186,195

Volz, H.P., 69

Virtanen, J., 67

Vital-Herne, J., 177

Vuorio, K., 67

Waddington, J.L., 177

Wadsworth, M.E.J., 25,26,27

Wagener, D.K., 227

Wagman, A.M., 193

Wahlberg, K-E.,69

Waldo, M., 250

Walker, E., 42,50,65,69

Wallace, C.J., 127,133

Wallace, D.C., 249

Walsleben, J., 177

Walsh, D., 67

Wang, G., 251

Waters, N., 251

Watt, D., 99

Watt, N.F., 44

Wegner, J.T., 165, 176,225

Weiden, PJ., 194

Weinberger, D.R., 66, 68, 69, 100, 177,

248

Weingartner, H., 250

Weissman, M.M., 132

Wells, J.E., 133

West, A., 44

Westenberg, H.G.M., 251

Westermeyer, J.F., 99

Weyerer, S., 133

Whatley, S.A., 249

Whisenand, T., 249

Whitmore, K., 27

Whitney, K.D., 249

Wible, C.G., 248

Wiegman, T., 179

Wieneke,A., 68

Wiersma, D., 248

Wiesel, F.A., 179, 193

Wieselgren, I.M., 228

Wightman, K.A., 251

Wilcox, G.L., 250

Wiles, D.H., 179,250

Wilkins, S., 119

Williams, S.c., 121

Willson, N., 249

Wilson, A., 179, 180

Wing, J.K., 27, 98, 126,133,178,226

Wirshing, D.A., 178, 179

Wirshing, W.c., 178,179

Woerner, M., 134, 177, 180,248,249

Wolf, A.P., 179, 195

Wolkin, A., 179,191,195

Wolkowitz, O.M., 193

Wolozin, B., 249

Wolpert, E.M., 98

Woodroffe, R.W., 134

Woodruff, P.W., 121

Wood, G.K., 248

Woods, B.T., 121, 177

Woods, S.W., 135

World Health Organization, 98, 133

Wozniak, D.F., 251

Wright, I.C., 121

Wyatt, R.J., 119,133,152,153,165,

177,225,248

Wynne, L.c., 69

Yale, c., 248

Yamatani, H., 228

Yamori, Y., 251

Yan, M.,66

Yang, L., 249

Yang, P., 251

Yang, Z.W., 249

Yao, J .K., 249, 250

Yasouka, F., 250

Yaziki, K.M., 179

Yeh, G-C., 251

Yuen,H.P.,121

Yung,A.R., 53-56, 66, 69, 72, 99, 101,

120-122,136-138,142,177,178,230

Zamkoff, J., 249

Zhang-Wong, J., 179

Ziebell, S., 177

Zijdenbos, A., 119,249

Zipursky, B., 167,178-180

Zorumski, C.F., 250

Zubin, J., 69, 99, 226

Zukin, S.R., 250

289