List of Products S. No Drug Name Manufacturing Process · by installing water meters, filing water...

Document No.: SBP/EC/18/018/V00 Page 1 of 1

List of Products

S. No Drug Name Manufacturing Process

1 Parathyroid Hormone Microbial

2 Streptokinase Microbial

3 Insulin Glargine Microbial

4 Insulin Aspart Microbial

5 Insulin Lispro Microbial

6 Human Insulin Microbial

Consent Order No: Date:CTE-303907 12/10/2017

To,

The Applicant,

Stellis Biopharma Private Limited

Sir,

Sub: Consent for Expansion of the unit in the Existing premises under the Water (Prevention & Control of Pollution) Act,1974 & the Air (Prevention & Control of Pollution) Act, 1981

Ref: 1.CFE expansion application submitted by the organization on 24/01/2017 at Regional Office KSPCB

2.Inspection of the project site by Regional Officer

on 27/02/2017

3.Proceedings of the CCM date 21/09/2017 held on11/09/2017

With reference to the above, Karnataka State Pollution Control Board hereby accords Consent for Expansion of the unit in the existing premises under the Water (Prevention & Control of Pollution) Act, 1974 & the Air (Prevention & Control of Pollution) Act, 1981 at the location indicated below subject to the terms & conditions indicated in Schedule Annexed.

Location:

Name of the Industry: Stellis Biopharma Private Limited

Address: Plot No. 293, Bommasandra 4th Phase, Indsutrial Area, Anekal Taluk,

Industrial Area: Bommasandra Jigani Link Road, Jigani,

Taluk: Anekal-Jigani hobli, District: Bangalore UrbanCONDITIONS:

3. The applicant shall not undertake further expansion/diversification without the prior consent of the Board.4. The applicant shall obtain necessary license/clearance from other relevant statutory agencies as required under the

law.

2. This consent for establishment is valid up to 30/06/2021 from the date of issue.

1. The Consent for Expansion is granted considering the following activities:

Sr Product Name CFE Qty CFO Qty Applied Qty/Month

Units Existing/Proposed

1 r & d laboratory-biotechnology(recombinant monoclonal antibodies.... @ 2nd floor

1.0000 0.000 - NOS 1.0000 NOS Proposed

2 research & development laboratory-biotechnology(recombinant monoclonal antibodie

1.0000 1.0000 - NOS 1.0000 NOS Existing

1. The source of water shall be from Borewell

Particulars Water Consumption(KLD) Water Discharge(KLD) Water Source Existing/Proposed

Domestic Purpose 5.5 4.4 Borewell Existing

Domestic Purpose 0.5 0.4 Borewell Proposed

Others ..... 0.7 0.7 Borewell Existing

Others ..... 1.6 1.6 Borewell Proposed

I. WATER CONSUMPTION:

and shall obtain prior permission from the concerneds

authority.Total water consumption shall not exceed as indicated below:

PCB ID: 27951

Page-1

CHIEF/SENIOR ENVIRONMENTAL OFFICERPrinted through XGNe_outwardno7058--12/10/2017

e-signed(physical si

Karnataka State Pollution Control BoardParisara Bhavana,No.49, Church

Street,Bengaluru-560001Tele : 080-25589112/3, 25581383

Fax:080-25586321email id: [email protected]

(This document contains 5 pages including annexure & excluding additional conditions)

Consent No. CTE-303907 Valid upto: 30/06/2021

Consent For Establishment -Expand(CFE-EXP)

Industry Colour: RED Industry Scale: LARGE

II. WATER POLLUTION CONTROL:1. The discharge from the premises of the applicant shall pass through the terminal manhole/manholes where from the Board shall be free to collect samples in accordance with the provisions of the Act/Rules made there under.

2. The sewage/domestic efflluent shall be treated in Septic Tank with Soak pit.No overflow from the soak pit is allowed.The septic tank and Soak pit shall be as per IS 2470 Part-I & Part-II.

3. The Effluent Treatment Plant proposal is generally agreeable and shall be constructed as per the specifications mentioned in the proposal and it shall consist of following units.

4. The industry shall treat the domestic wastewater in the Sewage Treatment Plant (STP) as per the proposal submitted. It shall meet the standards specified in Annexure-I & shall be used on land for gardening/greenbelt within the factory premises.

5. If the treatment plant does not achieve the effluent standards stipulated in this consent order and/ or if it is found to be inadequate, then the industry shall have to modify the units so as to meet the standards with prior consent of the Board.

6.All the treatment units shall be totally impervious.

7.The applicant shall provide separate flow meter for measuring the quantity of effluents through ETP and separate energy meter and shall maintain a logbook for the verification of inspecting officers.

8. The applicant shall operate and maintain Treatment Plant continuously and maintain at all times to achieve the stipulated standards as per Annexure-I & also maintain regular log-books/operation records.

9.There shall not be any increase in generation of Domestic sewage due to proposed expansion.

10. There shall be no bypass or discharge of effluents either within or outside the factory premises under any circumstances.

11. There shall not be any discharge of untreated trade/domestic sewage inside/outside the industry premises.

12. The applicant shall explore the possibility of reducing freshwater consumption & adopt recycling/ reuse.

III. WATER CESS:

1. The applicant shall comply with the provisions of Water (Prevention and Control of Pollution) Cess Act, 1977, by installing water meters, filing water cess returns in Form-I and other provisions as contained in the said Water (Prevention and Control of Pollution) Cess Act, 1977, and 2003.

IV. AIR POLLUTION CONTROL:

1. The type of emissions, stack heights and the air pollution control equipment for the air pollution control sources to be installed as specified in Annexure-II.

2. The discharge of emissions from the air pollution sources shall pass through the stacks/chimneys mentioned in Annexure-II where from the Board shall be free to collect the samples at any time in accordance with the provisions of the Act and Rules made there under.

3. The stacks shall have port holes and platforms as per the guidelines specified in Annexure-II to facilitate monitoring of emissions.

4. The applicant shall upgrade/modify/replace the control equipments if they are found inadequate to meet the standards stipulated with Prior permission of the Board shall be obtained for the same.

5. There shall not be any other sources of air pollution from the proposed expansion.

6. If there is going to be any new air pollution sources in future, the project authorities shall apply and obtain consent for establishment for the same from the Board.

7. Any fugitive emission has to be controlled to meet the ambient air quality standards.

V. SOLID WASTE (OTHER THAN HAZARDOUS WASTE) DISPOSAL:

1. The applicant shall collect, treat and dispose off all solid waste generated during construction i.e. Muck, and Garbage after construction if any in such manner so as not to cause environmental pollution.

2. The details of solid waste generated from the expansion activity shall be as follows

Sr Solid Waste Name Qty-Unit Mode of Disposal1 Paper wastes, Card Board Wastes etc., 0.0100 - M.T OTH

Page-2










2 Paper wastes, Card Board Wastes etc., 0.0100 - M.T OTH

VI.HAZARDOUS AND OTHER WASTES (MANAGEMENT & TRANSBOUNDRY MOVEMENT) RULES 2016:

1. The industry shall apply and obtain authorization under Hazardous and Other Wastes (Management &Transboundry Movement) Rules 2016, and comply with the conditions of the authorization. The applicant shall apply for authorization along with the consent for operation (CFO) application under the Rules in Form-I to obtain authorization and comply with conditions.

2. There shall not be any Hazardous Waste generation from the proposed expansion project.

VII. NOISE POLLUTION CONTROL:

1. The applicant shall ensure that the ambient noise levels within its premises shall not exceed the limits i.e 75 dB(A) Leq during day time and 70 dB(A) Leq during night time as specified in the Environment (Protection) Rules.

VIII. GENERAL CONDITIONS:

1. The applicant shall transport and store the raw materials in a manner so as not to cause any damage to environment, life and property. The applicant shall be solely responsible for any damages to environment.

2. The applicant shall not commission the proposed plant for trial or regular production unless necessary pollution control measures are installed as specified in this Consent Order.

3. The applicant shall ensure that the treatment plant and control equipments are completed and commissioned simultaneously along with construction of the factory and erection of machineries.

4. The applicant shall not change or alter (a) raw materials or manufacturing process, (b) change the products or product mix (c) the quality, quantity or rate of discharge/emissions and (d) install/replace/alter the water or air pollution control equipments without the prior approval of the Board.

5. The applicant shall immediately report to the Board of any accident or unforeseen act or event resulting in release of discharge of effluents or emissions or solid wastes etc. in excess of the standards stipulated. And the industry shall immediately take appropriate corrective and preventive actions under intimation.

6. The applicant is liable to reinstate or restore, damaged or destroyed elements of environment at his cost, failing which, the applicant/occupier as the case may be shall be liable to pay the entire cost of remediation or restoration in advance an amount equal to the cost estimated by Competent Agency or Committee.

7. The Board reserves the right to review, impose additional condition or conditions, revoke, change or alter the terms and conditions.

8. This CFE does not give any right to the Party/Project Authority/Industry to forego any other legal requirement that is necessary for setting/operation of the plant.

9. The applicant shall furnish point wise compliance to the conditions given under this consent for establishment within 30 days.

10. The applicant shall take measures to develop green belt all along the periphery of the factory premises.

11. This consent is issued without prejudice to any Court Cases pending in any Hon’ble Court 12. The applicant shall comply with all the Conditions and guidelines issued by the Board from time to time.

Please note that this is only consent for establishment issued to you to proceed with the formalities for expansion of the industry and does not give any right to proceed trial/regular production. For this purpose, separate consents of the Board for discharge of liquid effluent and the emissions to the air shall have to be obtained by remitting prescribed consent fee. The application forconsent has to be made 45 days in advance of commissioning for trial production of the plant.

The receipt of this letter may please be acknowledged.

NOTE:

The Conditions II [4], IV [ 1, 2, 3, 4 ]mentioned in the schedule are not applicable.

Error: Subreport could not be shown.

Page-3










FOR AND ON BEHALF OF KARNATAKA STATE POLLUTION CONTROL BOARD

B N RAMESH KUMAR - CHIEF/SENIOR ENVIRONMENTAL OFFICER

Encl.: Annexure-I & II.COPY TO:

1. The Environmental Officer, KSPCB, Regional Office Bangalore Anekal for information and necessary action.

1. Master copy (Dispatch).2. Office copy.

Chim.No.

Chimney attached to

Capacity/ KVA Rating

Minimum chimney height to be provided above ground level(in Mts)

Constituents to be controlled in the emission

Tolerance limits mg/NM3

Fuel Air pollutionControl equipment to be installed,in addition to chimney height as per col.(4)

Date of which air pollution control equipments shall be provided to achieve the stipulated tolerance limits and chimney heights conforming to stipulated heights.

1 Any Other........

Fume Cupboard-3 No's(Cmn

3 PM(mg/NM3),SO2(PPM),NOx(PPM)

Acid Mist-35

SCR Before commissioning.

2 Any Other........



Acid Mist-35


3 D.G. Sets

125 KVA DG Set


0,100,0 DIE AEC Before commissioning.

4 D.G. Sets

625 KVA DG Set



SCR : Scrubber

AEC : Accoustic Enclosures

Note:

Page-4










LOCATION OF SAMPLING PORTHOLES, PLATFORMS, ELECTRICAL OUTLET.1. Location of Portholes and approach platform:

Portholes shall be provided for all Chimneys, stacks and other sources of emission. These shall serve as the sampling points. The sampling point should be located at a distance equal to at least eight times the stack or duct diameter downstream from any flow disturbance such as bend, expansion, contraction and visible flame. Further, the selected port has to be at least 2 stack/duct diameter before stack/duct exit or from any other flow disturbance. For rectangular stacks, an equivalent diameter can be calculated using following expression.

2 (Length x Width) Equivalent Diameter = ----------------------- (Length + Width)2. The diameter of the sampling port should not be less than 100mm dia”.Arrangements should be made so that the porthole is closed firmly during the non sampling period.

3. An easily accessible platform to accommodate 3 to 4 persons to conveniently monitor the stack emission from the portholes shall be provided. Arrangements for an Electric Outlet Point off 230 V 15 A with suitable switch control and 3 Pin Point shall be provided at the Porthole location.

4. The ladder shall be provided with adequate safety features so as to approach the monitoring location with ease.

Page-5










Date: 30/12/2016

Combined consent for discharge of effluents under the Water (Prevention and Control of Pollution) Act , 1974 and emission under the Air (Prevention and Control of Pollution)Act , 1981

Ref: 1. Application filed by the applicant/organization on 08/08/2016

,held on 08/09/20163.Proceedings of the CCM dated 15/09/2016

2.Inspection of the Industry/organization/by RO,

on 08/08/2016on

Consent is hereby granted to the Occupier under Section 25(4) of the Water (Prevention & Control of Pollution) Act, 1974 ( herein referred to as the Water Act) & Section 21 of Air (Prevention & Control of Pollution) Act, 1981, ( herein referred to as the Air Act) and the Rules and Orders made there under and authorized the Occupier to operate /carryout industry/activity & to make discharge of the effluents & emissions confirming to the stipulated standards from the premises mentioned below and subject to the terms and conditions as detailed in the Schedule Annexed to this order.

Location:Name of the Industry: Stellis Biopharma Private Limited



Taluk: Anekal-Jigani hobli, District: Bangalore UrbanConditions:

a) Discharge of effluents under the Water Act:Sr Water Code WC(KLD) WWG(KLD) Remark1 Domestic Purpose 5.500 4.400 Domestic sewage shall be

disposed into Septic tank and Soak Pit.

2 Others ..... 0.650 0.650 Washing-trade effluent shall be hand over to CETP M/s Pai & Pai Chemicals India Pvt.Ltd.,

Sl. No. Description of chimney/outlet Limits specified refer schedule

The details of Sources, control equipments and its specification, type of fuel,constituents to be controlled in emissions etc. are detailed in Annexure-II.

b) Discharge of Air emissions under the Air Act from the following stacks etc.

The consent for operation is granted considering the following activities/Products;

Sr Product Name Applied Qty/Month Unit1 Research & Development laboratory-Biotechnology(Recombinant

Monoclonal Antibodie1.0000 NOS

This consent is valid for the period from 08/08/2016 30/06/2021

For and on behalf of the Karnataka State Pollution Control Board

to

B G MOHANKRISHNA

To,


Combined Consent Order No. AWH-301789 27951PCB ID:

CHIEF/SENIOR ENVIRONMENTAL OFFICERPrinted from XGNPage-1 e_outwardno3537--30/12/2016 e-signed(physical sig





Consent No. AWH-301789Valid upto: 30/06/2021

Consent For Operation(CFO-Air,Water)


COPY TO:

The Environmental Officer, KSPCB, Regional Office Bangalore Anekal for information and necessary action.

2. Master Register.

3. Case file.

1. Consent Fee paid : Rs. 150000

SCHEDULE

TERMS AND CONDITIONS

A. TREATMENT AND DISPOSAL OF EFFLUENTS UNDER THE WATER ACT.1. The discharge from the premises of the occupier shall pass through the terminal manhole/manholes where from the Board shall be free to collect samples in accordance with the provisions of the Act/Rules made there under.

2(a). The sewage/domestic effluent shall be treated in septic tank and with soak pit. No overflow from the soak pit is allowed. The septic tank and soak pit shall be as per IS 2470 Part-I & Part-II. 2(b). The treated sewage effluent discharged shall conform to the standards specified in Annexure-I.

3(a). The trade effluent generated in the industry shall be treated in the ETP and treated effluent shall confirm to the standards stipulated by the Board in Annexure-1 3(b). The trade effluent shall be handed over to CETP and maintain logbook of effluent generated & sent every day.

4. The applicant shall install flow measuring/recording devices to record the discharge quantity and maintain the record.

5. The applicant shall not change or alter either the quality or the quantity or the place of discharge or temperature or the point of discharge without the previous consent/ permission of the Board.

6. The applicant shall not allow the discharge from the other premises to mix with the discharge from his premises. Storm water shall not be allowed to mix with the effluents on the upstream of the terminal manhole where the flow measuring devices are installed.

7. The daily quantity of domestic effluent and trade effluent from the industry shall not exceed the limits as indicated in this consent order:

8. The applicant shall discharge the effluents only to the place mentioned in the Consent order and discharge of treated/untreated outside the premises is not permitted.

B. EMISSIONS:

1. The discharge of emissions from the premises of the applicant shall pass through the air pollution control equipment and discharged through stacks/chimneys mentioned in Annexure-II where from the Board shall be free to collect the samples at any time in accordance with the provisions of the Act and Rules made there under.The tolerance limits of the constituents forming the emissions in each of the stacks shall not exceed the limits laid down in Annexure-II.

2. The applicant shall provide port holes for sampling of emission, access platforms for carrying out stack sampling, electrical points and all other necessary arrangements including ladder as indicated in Annexure-II.

3. The applicant shall upgrade/modify/replace the control equipment with prior permission of the Board.

C. WATER CESS:

1. The applicant shall provide water meter at all the intake points as specified under Section (5) of the Water Cess Act, 1977 and shall file the Water Cess returns regularly before fifth of every month and also pay the Cess assessed with the time stipulated.









D.MONITORING & REPORTING:

1. The applicant shall get the samples of effluents & emissions collected and get them analyzed once a month/either by in house monitoring laboratory or through EP approved laboratories for the parameters as Indicated in Annexure I & II.

2. The applicant shall maintain log books to reflect the working condition of pollution control systems and also self monitoring results and keep it open for inspection.

E. SOLID WASTE (OTHER THAN HAZARDOUS WASTE) DISPOSAL:

1.The applicant shall segregate solid waste from Hazardous Waste, Municipal Solid Waste and store it properly till treatment/disposal without causing pollution to the surrounding Environment.

2.The solid waste generated shall be handled & disposed by scientific method without causing eye sore to the general public and to the surrounding environment.

F. NOISE POLLUTION CONTROL:

1. The industry shall ensure that the ambient noise levels within its premises shall not exceed the limits i.e 75 dB(A) Leq during day time and 70 dB(A) Leq during night time as specified in under the Air (Prevention and Control of Pollution) Act, 1981.

G. HAZARDOUS WASTES (MANAGEMENT, HANDLING & TRANSBOUDARY MOVEMENT) 2008:

The applicant shall comply with the provisions of the Hazardous Wastes (Management, Handling & Transboundry Movement) Rules 2008.

H. GENERAL CONDITIONS:

1. The applicant shall not allow the discharge from the other premises to mix with the discharge from his premises.

2. The applicant shall promptly comply with all orders and instructions issued by the Board from time to time or any other officers of the Board duly authorized in this behalf.

3. The applicant shall set-up Environmental Cell comprising of qualified and competent personnel for complying with the conditions specified.

4. The Board reserves the right to review, impose additional conditions, revoke, change or alter terms and conditions of this consent.

5. The applicant shall forthwith keep the Board informed of any accidental discharge of emissions/effluents into the atmosphere in excess of the standards laid down by the Board. The applicant shall also take corrective steps to mitigate the impact.

6. The applicant shall provide alternative power supply sufficient to operate all Pollution control equipments.

7. The entire premises shall always be kept clean. The effluent holding area, inspection chambers, outlets, flow measuring points should made easily approachable.

8. The applicant shall display the consent granted in a prominent place for perusal of the inspecting officers of the Board.

9. The applicant his heirs, legal representatives or assignee shall have no claims what so ever to the continuation or renewal of this consent after expiry of the validity of consent.









10. The applicant shall make an application for consent for subsequent period at least 45 days before expiry of this consent.

11. The applicant shall develop and maintain adequate green belt all around the periphery.

12. The applicant shall provide rain water harvesting system and shall provide proper storm water management system.

13.This consent is issued without prejudice to any Court Cases pending in any Hon’ble Court

14. The applicant shall furnish the Environmental statement for every financial year ending with 31st March in Form-V as per Environment (Protection) Rules, 1986. The statement shall be furnished before the end of September.

15.The applicant shall display flow diagram of the pollution control system near the pollution contol system/s.

NOTE:

The following Conditions A[ 2b ] mentioned in the schedule are not applicable.

Enclosed as Annexure-A.

Additional Conditions:


B G MOHANKRISHNA

Note: All efforts should be made to remove colour and unpleasant odour as far as practicable.









Chim.No.

Chimney attached to







1 Any Other........



Acid Mist-35


2 Any Other........



Acid Mist-35


3 D.G. Sets

125 KVA DG Set



4 D.G. Sets

625 KVA DG Set



SCR : Scrubber


Note:

Note: 1. The Noise levels within the premises shall not exceed 75 dB (A) leq during day time and 70 dB(A) leq during night time respectively. 2. The DG set shall be provided with acoustic measures as per SI.No.94 in Schedule-I of Environment (Protection)Rules. 3. There shall be no smell or odour nuisance from the industry.

LOCATION OF SAMPLING PORTHOLES, PLATFORMS, ELECTRICAL OUTLET.

1. Location of Portholes and approach platform:

Portholes shall be provided for all chimneys, stacks and other sources of emission. These shall serve as the sampling points. The sampling point should be located at a distance equal to atleast eight times the stack or duct diameters downstream and two diameters upstream from source of low disturbance such as a Bend, Expansion, Construction Valve, Fitting or Visible Flame for rectangular stacks, the equivalent diameter can be calculated from the following equation.

2 (Length x Width) Equivalent Diameter = ----------------------- (Length + Width)

2. The diameter of the sampling port should not be less than 100 mm dia”. Arrangements should be made so that the porthole is closed firmly during the non sampling period

3. An easily accessible platform to accommodate 3 to 4 persons to conveniently monitor the stack emission from the portholes shall be provided. Arrangements for an Electric Outlet Point of 230 V 15 A with suitable switch control and 3 Pin Point shall be provided at the Porthole location.


Click Here to View Uploaded Document1









http://xgn.karnataka.gov.in/xgn/NOC/VIEW_PDF.aspx?gpcbid=27951,14446,1

Date: 21/06/2018

Combined consent for discharge of effluents under the Water (Prevention and Control of Pollution) Act , 1974 and emission under the Air (Prevention and Control of Pollution)Act , 1981

Ref: 1. Application filed by the applicant/organization on

,held on 06/04/20183.Proceedings of the CCM dated 23/04/2018

on 16/02/20182.Inspection of the Industry/organization/by RO,

24/02/2018

Consent is hereby granted to the Occupier under Section 25(4) of the Water (Prevention & Control of Pollution) Act, 1974 ( herein referred to as the Water Act) & Section 21 of Air (Prevention & Control of Pollution) Act, 1981, ( herein referred to as the Air Act) and the Rules and Orders made there under and authorized the Occupier to operate /carryout industry/activity & to make discharge of the effluents & emissions confirming to the stipulated standards from the premises mentioned below and subject to the terms and conditions as detailed in the Schedule Annexed to this order.

Location:Name of the Industry: Stellis Biopharma Private Limited



Taluk: Anekal-Jigani hobli, District: Bangalore UrbanCONDITIONS:

a) Discharge of effluents under the Water Act:Sr Water Code WC(KLD) WWG(KLD) Remark1 Domestic Purpose 5.500 4.400 Shall be treated in 10 KLD

Combined ETP and used onland for gardening and toilet flushing.

2 Domestic Purpose 0.500 0.360 Proposed -Shall be treated in 10 KLD Combined ETP and used onland for gardening and toilet flushing.

3 Others ..... 0.650 0.650 Shall be treated in 10 KLD Combined ETP and used onland for gardening and toilet flushing.

4 Others ..... 1.600 1.600 Proposed - Shall be treated in 10 KLD Combined ETP and used onland for gardening and toilet flushing

Sl. No. Description of chimney/outlet Limits specified refer schedule

The details of Sources, control equipments and its specification, type of fuel,constituents to be controlled in emissions etc. are detailed in Annexure-II.

b) Discharge of Air emissions under the Air Act from the following stacks etc.

The consent for operation is granted considering the following activities/Products;

Sr Product Name Applied Qty/Month Unit1 R&D laboratory-biotechnology(recombinant monoclonal

antibiotics....@2nd floor1.0000 NOS

2 Research & Development laboratory-Biotechnology(Recombinant Monoclonal Antibodie

1.0000 NOS

This consent is valid for the period from 24/02/2018 30/06/2021


to


Combined Consent Order No. W-306482 27951PCB ID:






Consent No. W-306482Valid upto: 30/06/2021



To,


COPY TO:

The Environmental Officer, KSPCB, Regional Office Bangalore Anekal for information and necessary action.

2. Master Register.

3. Case file.

Consent Fee paid : Rs. 250000

SCHEDULE

TERMS AND CONDITIONS

A. TREATMENT AND DISPOSAL OF EFFLUENTS UNDER THE WATER ACT.1. The discharge from the premises of the occupier shall pass through the terminal manhole/manholes where from the Board shall be free to collect samples in accordance with the provisions of the Act/Rules made there under.

2(a). The sewage/domestic effluent shall be treated in septic tank and with soak pit. No overflow from the soak pit is allowed. The septic tank and soak pit shall be as per IS 2470 Part-I & Part-II. 2(b). The treated sewage effluent discharged shall conform to the standards specified in Annexure-I.

3(a). The trade effluent generated in the industry shall be treated in the ETP and treated effluent shall confirm to the standards stipulated by the Board in Annexure-I 3(b). The trade effluent shall be handed over to CETP and maintain logbook of effluent generated & sent every day.

4. The applicant shall install flow measuring/recording devices to record the discharge quantity and maintain the record.

5. The applicant shall not change or alter either the quality or the quantity or the place of discharge or temperature or the point of discharge without the previous consent/ permission of the Board.

6. The applicant shall not allow the discharge from the other premises to mix with the discharge from his premises. Storm water shall not be allowed to mix with the effluents on the upstream of the terminal manhole where the flow measuring devices are installed.

7. The daily quantity of domestic effluent and trade effluent from the industry shall not exceed the limits as indicated in this consent order:

8. The applicant shall discharge the effluents only to the place mentioned in the Consent order and discharge of treated/untreated outside the premises is not permitted.

B. EMISSIONS:

1. The discharge of emissions from the premises of the applicant shall pass through the air pollution control equipment and discharged through stacks/chimneys mentioned in Annexure-II where from the Board shall be free to collect the samples at any time in accordance with the provisions of the Act and Rules made there under.The tolerance limits of the constituents forming the emissions in each of the stacks shall not exceed the limits laid down in Annexure-II.

2. The applicant shall provide port holes for sampling of emission, access platforms for carrying out stack sampling, electrical points and all other necessary arrangements including ladder as indicated in Annexure-II.

3. The applicant shall upgrade/modify/replace the control equipment with prior permission of the Board.









C. WATER CESS:

1. The applicant shall provide water meter at all the intake points as specified under Section (5) of the Water Cess Act, 1977 and shall file the Water Cess returns regularly before fifth of every month and also pay the Cess assessed with the time stipulated.

D.MONITORING & REPORTING:

1. The applicant shall get the samples of effluents & emissions collected and get them analyzed once a month/either by in house monitoring laboratory or through EP approved laboratories for the parameters as Indicated in Annexure I & II.

2. The applicant shall maintain log books to reflect the working condition of pollution control systems and also self monitoring results and keep it open for inspection.

E. SOLID WASTE (OTHER THAN HAZARDOUS WASTE) DISPOSAL:

1.The applicant shall segregate solid waste from Hazardous Waste, Municipal Solid Waste and store it properly till treatment/disposal without causing pollution to the surrounding Environment.

2.The solid waste generated shall be handled & disposed by scientific method without causing eye sore to the general public and to the surrounding environment.

F. NOISE POLLUTION CONTROL:

1. The applicant shall ensure that the ambient noise levels within its premises shall not exceed the limits i.e 75 dB(A) Leq during day time and 70 dB(A) Leq during night time as specified in under the Air (Prevention and Control of Pollution) Act, 1981.

G. HAZARDOUS AND OTHER WASTES (MANAGEMENT & TRANSBOUDARY MOVEMENT)Rules 2016:

The applicant shall comply with the provisions of the Hazardous and other Wastes (Management & Transboundry Movement) Rules 2016.

H. GENERAL CONDITIONS:

1. The applicant shall not allow the discharge from the other premises to mix with the discharge from his premises.

2. The applicant shall promptly comply with all orders and instructions issued by the Board from time to time or any other officers of the Board duly authorized in this behalf.

3. The applicant shall set-up Environmental Cell comprising of qualified and competent personnel for complying with the conditions specified.

4. The Board reserves the right to review, impose additional conditions, revoke, change or alter terms and conditions of this consent.

5. The applicant shall forthwith keep the Board informed of any accidental discharge of emissions/effluents into the atmosphere in excess of the standards laid down by the Board. The applicant shall also take corrective steps to mitigate the impact.

6. The applicant shall provide alternate power supply sufficient to operate all Pollution control equipments.

7. The entire premises shall always be kept clean. The effluent holding area, inspection chambers, outlets, flow measuring points should made easily approachable.

8. The applicant shall display the consent granted in a prominent place for perusal of the inspecting officers of the Board.

9. The applicant his heirs, legal representatives or assignee shall have no claims what so ever to the continuation or renewal of this consent after expiry of the validity of consent.









10. The applicant shall make an application for consent for subsequent period at least 45 days before expiry of this consent.

11. The applicant shall develop and maintain adequate green belt all around the periphery.

12. The applicant shall provide rain water harvesting system and shall provide proper storm water management system.

13.This consent is issued without prejudice to any Court Cases pending in any Hon’ble Court

14. The applicant shall furnish the Environmental statement for every financial year ending with 31st March in Form-V as per Environment (Protection) Rules, 1986. The statement shall be furnished before the end of September.

15.The applicant shall display flow diagram of the pollution control system near the pollution contol system/s.

NOTE:

The Conditions A [ 2a, 2b, 3b ] mentioned in the schedule are not applicable.

The applicant shall comply with all the additional conditions stipulated in the Annexure enclosed with this consent (Please download Annexure-A from uploaded document).

Additional Conditions:











Chim.No.

Chimney attached to







1 Any Other........



Acid Mist-35


2 Any Other........



Acid Mist-35


3 D.G. Sets

125 KVA DG Set



4 D.G. Sets

625 KVA DG Set



SCR : Scrubber


Note:

Note: 1. The Noise levels within the premises shall not exceed 75 dB (A) leq during day time and 70 dB(A) leq during night time respectively. 2. The DG set shall be provided with acoustic measures as per SI.No.94 in Schedule-I of Environment (Protection)Rules. 3. There shall be no smell or odour nuisance from the industry.

LOCATION OF SAMPLING PORTHOLES, PLATFORMS, ELECTRICAL OUTLET.

1. Location of Portholes and approach platform:

Portholes shall be provided for all chimneys, stacks and other sources of emission. These shall serve as the sampling points. The sampling point should be located at a distance equal to atleast eight times the stack or duct diameters downstream and two diameters upstream from source of low disturbance such as a Bend, Expansion, Construction Valve, Fitting or Visible Flame for rectangular stacks, the equivalent diameter can be calculated from the following equation.

2 (Length x Width) Equivalent Diameter = ----------------------- (Length + Width)

2. The diameter of the sampling port should not be less than 100 mm dia”. Arrangements should be made so that the porthole is closed firmly during the non sampling period

3. An easily accessible platform to accommodate 3 to 4 persons to conveniently monitor the stack emission from the portholes shall be provided. Arrangements for an Electric Outlet Point of 230 V 15 A with suitable switch control and 3 Pin Point shall be provided at the Porthole location.










SEPTIC

TANK &

SOAK

PITS

UNDERGROUND

SUMP BELOW

DRIVEWAY

(50,000 LTS)

7000mm WIDE DRIVEWAY

6000m

m W

ID

E D

RIV

EW

AY

6000m

m W

ID

E D

RIV

EW

AY

Entry

FIR

E H

YD

RA

NT

R

AIS

ER

62

5 K

VA

D

G S

ET

SOUN

D PR

OOF

ACOU

STIC

12

5 K

VA

D

G S

ET

UP

UP

EXIS

TING

STA

IR C

ASE

FIR

E H

OS

E

CA

BIN

ET

-2

FIRE HOSE

CABINET-3

FIRE HOSE

CABINET-4

150-FIRE HYDRANT-GI

150-FIRE HYDRANT-GI

25

00

53

00

4.1

0M

3600109006000

74

00

10900

2200

22

00

88580

44300

20200 69700

6000

60

00

NO.49,BEHIND ANJANA MINI HALL, MATHIKERE BUS STOP, BANGALORE 54

23371171, 23475699

PLAN SHOWING THE EXISTING FACTORY BUILDING AND

DRG NO. S.B.P.L- 001 - 01/02

PLOT NO.293,

BOMMASANDRA JIGANI LINK ROAD,

JIGANI INDUSTRIAL AREA,

ANEKAL TALUK,

BANGALORE - 560 105.

1 : 200

APPLICANTS SIGNATURE

SYMBOL

DESCRIPTION

4-WAY FIRE BRIGADE INLET

LEGEND:

SCALE:- 1:200

GA

TE

VACANT LAND

70

00

D

DN DN

14-09-2016

40

00

A - MAIN BUILDING

B - SECURITY ROOM

8

9

REVISED MACHINERY LAYOUT FOR

AREA ALREADY APPROVED

FPN / CR - 258 / 2013-014

DATED : 30-04-2014

PRIN

TER

FULL

HEI

GHT

CABI

NETS

VP

-1


Microbial manufacturing flow chart:

FINAL STERILE FILTRATION

VACUUM CONCENTRATION (IF APPLICABLE)

CONCENTRATION / BUFFER EXCHANGE BY TFF

POLISHING BY CHROMATOGRAPHY

2 STAGES OF CHROMATOGRAPHY PURIFICATION

REFOLDING (IF APPLICABLE)

CELL HOMOGENIZATION

CELL HARVEST OR CLARIFICATION

FULL SCALE BIOREACTOR PROCESS (FERMENTATION)

INOCULUM GENERATION IN SHAKE FLASK &

SMALL FERMENTER

THAWING OF WORKING CELL BANK

MED

IA FILTR

ATION

BUFFER

FILTR

ATION


Description of Manufacturing Process Upstream Process

The inoculum generation is initiated with thawing of a vial from a cell bank. The cells

from the vial are expanded in conical flasks to obtain the desired amount of inoculum

for starting a 2L- 5L bioreactor. The mode of running the bioreactor is batch / Fed

Batch. The cells are allowed to grow for few hours in batch mode after which feeds of

nutrients like glucose, and salts are fed in the bioreactor at different flow rates.

The bioreactor is harvested at the end of the fermentation, centrifuged and taken for cell

separation.

Cell Harvest clarification: Continuous centrifugation is to separate the cells from the

fermentation media, the pellet of which will be homogenized and followed by depth

filtration/microfiltration.

All the activities that involve cells / cell separation shall be performed in the upstream

area. Cell free /supernatant shall be transferred to DSP for further purification.

Downstream Process

• CAPTURE BY IEX/HCIC CHROMATOGRAPHY: target protein is among thousands

of impurities will be specifically retained over the IEX/HCIC resin leaving impurities

as unbound.

• REFOLDING (AS APPLICABLE): if the protein is in insoluble form, to get back its

3D structure, refolding of protein in a controlled physical and chemical environment

(temperature between 2-25˚C) shall be performed.

• PURIFICATION BY HIC/ ION EXCHANGE CHROMATOGRAPHY: Either Anion

or Cation exchange chromatography is employed for this particular step.

• Polishing Chromatography: SEC or product specific resins shall be used to remove the

related impurities that needs to be separated from the target protein.

• CONCENTRATION / BUFFER EXCHANGE BY TFF: is critical to bring in the

product to the required pre/formulation buffer which ensures the stability.

• Final sterile filtration is required to claim that the product is sterile and is qualified for

fill finish requirement.


• Samples are collected at different stages during the batch and sent to QC for analytical

testing.

Analytical development:

In the process of biological product development, the most important aspect is the thorough

characterization of the molecules at different stages of process development of drug

substances including in process steps, formulation activities to convert drug substance to

drug product, stability studies etc. Also all the activities related to process characterization

studies for analysis of the product and related impurities shall be performed by existing

analytical development team.

Formulation:

The process of converting drug substance into a stable administrative form for the targeted

use is formulation development. The typical process of formulation development involves,

screening excipients, screen pH, screen the compatibility of stabilizers and find out the

stability of the active ingredient. If the formulation is not stable in the liquid conditions,

then a process of Lyophilisation is used to increase the shelf life of the drug. The Lyo

facility shall be utilized from R & D centre.

Based on the inputs from R & D, pilot batches shall be taken in pilot scale lab using

multipurpose system that can handle vials, PFS, and cartridges.


1. Water Balance Chart for Existing R&D Raw Water = 6.2KLD

2. Water Balance Chart for Existing PSL

Raw Water = 2.1KLD

Domestic activity (Green belt & Flushing) 0.5KLD

Process (Washing & Others) – 1.6KLD

Domestic sewage– 0.4KLD


Handed over to CETP of M/s. Pai and Pai Chemicals India private Limited for further

treatment and disposal

Disposed through Septic Tank and Soak pit

Domestic activity (Green belt & Flushing) – 5.5KLD

Process (Washing & Others) – 0.7 KLD

Domestic sewage – 4.4KLD

Process (Washing & Others) – 0.7 KLD

Handed over to CETP of M/s. Pai and Pai Chemicals India private Limited for further

treatment and disposal

Disposed through Septic Tank and Soak pit


3. Proposed Water Balance Chart

Raw Water = 3.3KLD

4. Total Water Balance Chart

Raw Water = 9.5KLD

Domestic activity – 1.0KLD Process (Washing & Others) – 2.3KLD

Domestic sewage – 1.0KLD Process (Washing & Others) – 2.3KLD

Recycling through in-house ETP 0.5 KLD Flushing

through Septic Tank and Soak pit

Domestic activity –

6.5KLD


Domestic sewage – 5.4KLD


Green Belt – 1.8KLD Cooling tower - 1.0KLD

Recycling through in-house ETP

Green Belt – 3.0KLD Cooling tower - 5.4KLD

0.5KLD Recycling through in-house ETP


List of Raw Materials:

S. No Name of material Make Quantity /

Annum Units

1 Ammonia solutions Merck 276 L

2 Di-ammonium hydrogen phosphate Merck 20133 g

3 Potassium di-hydrogen phosphate Merck 57694.2 g

4 Magnesium sulphate Heptahydrate J.T Baker 16719.6 g

5 D-glucose anhydrous Macron 747.2 Kg

6 IPTG Calbiochem 856.8 g

7 antifoam 204 Sigma 2400 mL

8 Kanamycin acid sulphate Calbiochem 324 g

9 Tryptone BD 111600 g

10 Yeast Extract BD 39600 g

11 Citric acid monohydrate J.T Baker 6500 g

12 EDTA Merck 77.6 Kg

13 Cobalt(ll) chloride hexahydrate Merck 18 g

14 Manganese Chloride Spectrum 36 g

15 Copper (lll) sulphate pentahydrate Merck 10.8 g

16 Boric acid Panreac 10.2 g

17 Sodium Molybdate Merck 12 g

18 Zinc Suphate J.T Baker 40.8 g

19 Ferric Chloride Merck 240 g

20 IPTG Calbiochem 6000 g

21 Silicon antifoam Sigma 9000 mL



Annum Units

22 Thiamin hydrochloride J.T.Baker 60 g

23 Sodium hydroxide Merck 306 Kg

24 OPA(85%) J.T Baker 6000 mL

25 Iron (lll) Chloride Merck 162 g

26 Zinc Chloride J.T Baker 312 g

27 Calcium chloride dihydrate Spectrum 250 g

28 HCl Merck 125 L

29 NaCl Merck 522 Kg

30 MES 2-(N-morpholino) ethanol Sulfonic acid

Calbiochem 5892 g

31 PMSF Calbiochem 1409.4 g

32 Imidazole Calbiochem 38.28 Kg

33 Sodium Acetate Merck 14.76 Kg

34 Nickel Sulphate Thermo 185.78 Kg

35 Dithiothreitol Sidhhi 9240 g

36 Methanol Merck 81 L

37 Acetic acid glacial Merck 44 L

38 Trifloro Acetic acid Thermo 4875 mL

39 Acetonitrile Merck 1380 L

40 Ethanol Absolute Panreac 466.5 L

41 EK Hangzhou 1320 mL

42 Tris (Hydroxymethyl) amino Methane

Merck 130 Kg

43 Triton x-100 Merck 3.5 Kg



Annum Units

44 Tween-20 Merck 3.1 Kg

45 L-Cysteine Merck 0.5 Kg

46 Mercaptoethanol Sigma Aldrich

187.5 mL

47 L-Arginine J.T. Baker 15.6 Kg

48 Imidazole Calbiochem (Merck)

7.1 Kg

49 Citraconic anhydride Thermo fisher

300.0 g

50 Trypzean Sigma Aldrich

1500.0 mg

51 N-Propanol Merck 611.9 L

52 Sodium sulphate Merck 39.0 Kg

53 Sodium Phosphate Dibasic Merck 937.5 g

54 L-Glycine Merck 315.0 g

55 Orthophosphoric acid JT Baker 75.0 ml

SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006

Revision Date 17.01.2017 Version 1.3

The Safety Data Sheets for catalogue items are available at www.merckgroup.com Page 1 of 18

SECTION 1. Identification of the substance/mixture and of the company/undertaking

1.1 Product identifier

Catalogue No. 105423

Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur

REACH Registration Number This product is a mixture. REACH Registration Number see section 3.

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses Reagent for analysis, Chemical production For additional information on uses please refer to the Merck Chemicals

portal (www.merckgroup.com).

1.3 Details of the supplier of the safety data sheet

Company Merck Life Science Private Limited * 8th Floor, Godrej One, Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079 India * Tel: 0091 22 6210 9000

Responsible Department Quality Assurance * Merck Life Science Private Limited *

e-mail: [email protected] *

Tel : +91-2267863131-6

1.4 Emergency telephone number

Please contact the regional company representation in your country.

SECTION 2. Hazards identification

2.1 Classification of the substance or mixture Classification (REGULATION (EC) No 1272/2008)


Catalogue No. 105423 Product name Ammonia solution 28-30% for analysis EMSURE® ACS,Reag. Ph Eur


Corrosive to metals, Category 1, H290 Skin corrosion, Category 1B, H314 Specific target organ toxicity - single exposure, Category 3, Respiratory system, H335 Acute aquatic toxicity, Category 1, H400

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 Label elements

Labelling (REGULATION (EC) No 1272/2008) Hazard pictograms

Signal wordDanger Hazard statementsH290 May be corrosive to metals. H314 Causes severe skin burns and eye damage. H335 May cause respiratory irritation. H400 Very toxic to aquatic life. Precautionary statementsPrevention P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. Response P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.




Reduced labelling (≤125 ml)

Hazard pictograms

Signal wordDanger

Hazard statementsH314 Causes severe skin burns and eye damage.

Precautionary statementsP280 Wear protective gloves/ protective clothing/ eye protection/ face protection. P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.

2.3 Other hazards

None known.

SECTION 3. Composition/information on ingredients

Chemical nature Aqueous ammoniacal solution. 3.1 Substance

Not applicable

3.2 Mixture

Hazardous components (REGULATION (EC) No 1272/2008)Chemical Name (Concentration) CAS-No. Registration number Classification ammonia solution (>= 25 % - < 50 % ) Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.

1336-21-6 *) Corrosive to metals, Category 1, H290 Skin corrosion, Category 1B, H314




Specific target organ toxicity - single exposure, Category 3, H335Acute aquatic toxicity, Category 1, H400

*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.


SECTION 4. First aid measures

4.1 Description of first aid measures

General adviceFirst aider needs to protect himself.

After inhalation: fresh air. Call in physician.

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.

After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove contact lenses.

After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not attempt to neutralise.

4.2 Most important symptoms and effects, both acute and delayed Irritation and corrosion, bronchitis, Cough, Shortness of breath, gastric pain, Unconsciousness, Bloody vomiting, Nausea, collapse, shock, Convulsions, Lung oedema, death Risk of blindness!

4.3 Indication of any immediate medical attention and special treatment needed No information available.

SECTION 5. Firefighting measures

5.1 Extinguishing media




Suitable extinguishing mediaUse extinguishing measures that are appropriate to local circumstances and the surrounding environment.

Unsuitable extinguishing mediaFor this substance/mixture no limitations of extinguishing agents are given.

5.2 Special hazards arising from the substance or mixture

Not combustible. Ammonia solution itself is not flammable, but can form an ignitable ammonia/air-mixture by outgassing. Ambient fire may liberate hazardous vapours. Fire may cause evolution of: nitrogen oxides

5.3 Advice for firefighters

Special protective equipment for firefightersStay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further informationCool closed containers exposed to fire with water spray. Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

SECTION 6. Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapours, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.

Advice for emergency responders:

Protective equipment see section 8.

6.2 Environmental precautions

Do not empty into drains.




6.3 Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent and neutralising material (e.g. Chemizorb® OH⁻, Merck Art. No. 101596). Dispose of properly. Clean up affected area.

6.4 Reference to other sectionsIndications about waste treatment see section 13.

SECTION 7. Handling and storage

7.1 Precautions for safe handling

Advice on safe handlingObserve label precautions.

Hygiene measuresImmediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

7.2 Conditions for safe storage, including any incompatibilities

Requirements for storage areas and containersNo metal or light-weight-metal containers.

Storage conditionsTightly closed.

Recommended storage temperature see product label.

7.3 Specific end use(s)Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.

SECTION 8. Exposure controls/personal protection

8.1 Control parameters




ammonia solution (1336-21-6)IN OEL Short Term Exposure

Limit (STEL): 35 ppm 27 mg/m³

Time Weighted Average (TWA):

25 ppm 18 mg/m³

8.2 Exposure controls

Engineering measures Technical measures and appropriate working operations should be given priority over the use of personal protective equipment. See section 7.1. Individual protection measures Protective clothing needs to be selected specifically for the workplace, depending on concentrations and quantities of the hazardous substances handled. The chemical resistance of the protective equipment should be enquired at the respective supplier.

Eye/face protectionTightly fitting safety goggles

Hand protection

full contact: Glove material: butyl-rubber Glove thickness: 0.7 mm Break through time: > 480 min

splash contact: Glove material: Nitrile rubber Glove thickness: 0.40 mm Break through time: > 240 min

The protective gloves to be used must comply with the specifications of EC Directive 89/686/EEC and the related standard EN374, for example KCL 898 Butoject® (full contact), KCL 730 Camatril® -Velours (splash contact).




The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374 with samples of the recommended glove types. This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Other protective equipmentprotective clothing

Respiratory protectionrequired when vapours/aerosols are generated. Recommended Filter type: Filter K (acc. to DIN 3181) for NH₃ The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.

Environmental exposure controlsDo not empty into drains.

SECTION 9. Physical and chemical properties

9.1 Information on basic physical and chemical properties

Form liquid

Colour colourless

Odour stinging

ammoniacal

Odour Threshold 0.03 - 0.05 ppm

Ammonia




pH > 12

at 20 °C

strongly alkaline

Melting point ca. -72 °C

Boiling point/boiling range ca. 32 °C

Flash point Not applicable

Evaporation rate No information available.

Flammability (solid, gas) No information available.

Lower explosion limit 15.4 %(V)

Upper explosion limit 33.6 %(V)

Vapour pressure 635 hPa

at 20 °C

Relative vapour density No information available.

Density 0.90 g/cm3 at 20 °C

Relative density No information available.

Water solubility at 20 °C soluble

Partition coefficient: n-octanol/water

log Pow: -1.38 (experimental) (anhydrous substance) Bioaccumulation is not expected.




Auto-ignition temperature No information available.

Decomposition temperature No information available.

Viscosity, dynamic No information available.

Explosive properties Not classified as explosive.

Oxidizing properties none

9.2 Other data

Minimum ignition energy 380 - 680 mJ

Corrosion May be corrosive to metals.

SECTION 10. Stability and reactivity

10.1 Reactivity

See section 10.3

10.2 Chemical stability

Ammonia solution itself is not flammable, but can form an ignitable ammonia/air-mixture by outgassing.

10.3 Possibility of hazardous reactions

A risk of explosion and/or of toxic gas formation exists with the following substances:

Oxidizing agents, Mercury, Oxygen, silver compounds, nitrogen trichloride, hydrogen peroxide, silver, antimony hydride, halogens, Acids, Calcium, Chlorine, Chlorites, auric salts, perchlorates, sodium hypochlorite, mercury compounds, halogen oxides

Heavy metals, Heavy metal salts, Acid chlorides, Acid anhydrides

Risk of ignition or formation of inflammable gases or vapours with:

Boranes, Boron, Oxides of phosphorus, Nitric acid, silicon compounds, chromium(VI) oxide, chromyl chloride




Exothermic reaction with:

Acetaldehyde, Acrolein, Barium, boron compounds, Bromine, halogen-halogen compounds, hydrogen bromide, silane, Hydrogen chloride gas, halogen compounds, dimethylsulfate, nitrogen oxides, Fluorine, Hydrogen fluoride, chlorates, carbon dioxide

Ethylene oxide, polymerisable

10.4 Conditions to avoid

Heating.

10.5 Incompatible materials

Aluminium, Lead, Nickel, silver, Zinc, Copper, metal alloys, various metals

10.6 Hazardous decomposition products

in the event of fire: See section 5.

SECTION 11. Toxicological information

11.1 Information on toxicological effects Mixture

Acute oral toxicityLDLO human: 43 mg/kg (29% solution) (RTECS)

Symptoms: gastric pain, Bloody vomiting, If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the oesophagus and the stomach.

If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the oesophagus and the stomach.

Acute inhalation toxicity Symptoms: mucosal irritations, Cough, Shortness of breath, bronchitis, Possible damages:, damage of respiratory tract

Acute dermal toxicityThis information is not available.




Skin irritationRabbit Result: Severe irritations (29% solution) (RTECS) Dermatitis Necrosis Mixture causes burns.

Eye irritationRabbit Result: Severe irritations (29% solution) (RTECS) Mixture causes serious eye damage. Risk of blindness!

SensitisationThis information is not available.

Germ cell mutagenicityThis information is not available.

CarcinogenicityThis information is not available.

Reproductive toxicityThis information is not available.

TeratogenicityThis information is not available.

Specific target organ toxicity - single exposureMixture may cause respiratory irritation. Target Organs: Respiratory system

Specific target organ toxicity - repeated exposureThis information is not available.

Aspiration hazardThis information is not available.




11.2 Further information

Systemic effects: Nausea, collapse, shock, Unconsciousness, Convulsions Lung oedema, Possible effects: death Handle in accordance with good industrial hygiene and safety practice. Components

ammonia solution

No information available.

SECTION 12. Ecological information

Mixture

12.1 Toxicity


12.2 Persistence and degradability

Biodegradability

Not readily biodegradable.

12.3 Bioaccumulative potential

Partition coefficient: n-octanol/waterlog Pow: -1.38 (experimental) (anhydrous substance) Bioaccumulation is not expected.

12.4 Mobility in soil


12.5 Results of PBT and vPvB assessmentSubstance(s) in the mixture do(es) not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII, or a PBT/vPvB assessment was not conducted.

12.6 Other adverse effects




Additional ecological informationBiological effects: Harmful effect due to pH shift. Forms toxic and corrosive mixtures with water even if diluted. Discharge into the environment must be avoided. Components ammonia solution

Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.




SECTION 13. Disposal considerations

Waste treatment methodsWaste material must be disposed of in accordance with the national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself. See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

SECTION 14. Transport information

Land transport (ADR/RID)

14.1 UN number UN 2672

14.2 Proper shipping name AMMONIA SOLUTION

14.3 Class 8

14.4 Packing group III

14.5 Environmentally hazardous yes

14.6 Special precautions for user

yes

Tunnel restriction code E

Inland waterway transport (ADN)

Not relevant

Air transport (IATA)



14.3 Class 8







no

Sea transport (IMDG)



14.3 Class 8




yes

EmS F-A S-B

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code Not relevant

SECTION 15. Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture

National legislation

Storage class 8B

15.2 Chemical Safety Assessment

For this product a chemical safety assessment was not carried out.

SECTION 16. Other information

Full text of H-Statements referred to under sections 2 and 3.

H290 May be corrosive to metals. H314 Causes severe skin burns and eye damage. H335 May cause respiratory irritation. H400 Very toxic to aquatic life.




Training advice Provide adequate information, instruction and training for operators. Labelling

Hazard pictograms

Signal wordDanger Hazard statementsH290 May be corrosive to metals. H314 Causes severe skin burns and eye damage. H335 May cause respiratory irritation. H400 Very toxic to aquatic life. Precautionary statementsPrevention P273 Avoid release to the environment. P280 Wear protective gloves/ protective clothing/ eye protection/ face protection. Response P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.

Key or legend to abbreviations and acronyms used in the safety data sheet

Used abbreviations and acronyms can be looked up at www.wikipedia.org.




The information contained herein is based on the present state of our knowledge. It characterises the product with regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.


Date of issue: 06.05.2014 Version 1.0

The Safety Data Sheets for catalogue items are available at www.merckgroup.com

Page 1 of 8




Product name di-Ammonium hydrogen phosphate for analysis EMSURE®

ACS,Reag. Ph Eur

REACH Registration Number A registration number is not available for this substance as the

substance or its use are exempted from registration according to

Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage

does not require a registration or the registration is envisaged for a

later registration deadline.

CAS-No. 7783-28-0


Identified uses Reagent for analysis

For additional information on uses please refer to the Merck Chemicals

portal (www.merck-chemicals.com).


Company Merck Life Science Private Limited * 8th Floor, Godrej One,

Pirojshanagar, Eastern Express HighwayVikhroli (E),Mumbai – 400079

India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6

1.4 Emergency telephone

number



2.1 Classification of the substance or mixture

This substance is not classified as dangerous according to European Union legislation.

2.2 Label elements

Labelling (REGULATION (EC) No 1272/2008)

Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008.

2.3 Other hazards

None known.


3.1 Substance

Formula (NH₄)₂HPO₄ H₉N₂O₄P (Hill)

EC-No. 231-987-8

Molar mass 132.05 g/mol

SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006


Product name di-Ammonium hydrogen phosphate for analysis EMSURE® ACS,Reag. Ph Eur


Page 2 of 8


Remarks No disclosure requirement according to Regulation (EC) No.

1907/2006

3.2 Mixture

not applicable



After inhalation: fresh air.

After skin contact: wash off with plenty of water. Remove contaminated clothing.

After eye contact: rinse out with plenty of water.

After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling unwell.

4.2 Most important symptoms and effects, both acute and delayed

Diarrhoea

The following applies to ammonium salts in general: after swallowing: local irritation symptoms,

nausea, vomiting, diarrhoea. Systemic effect: after the uptake of very large qantities: drop in

blood pressure, collapse, CNS disorders, spasms, narcotic conditions, respiratory paralysis,

haemolysis.

4.3 Indication of any immediate medical attention and special treatment needed




Suitable extinguishing mediaUse extinguishing measures that are appropriate to local circumstances and the surrounding

environment.



Not combustible.

Ambient fire may liberate hazardous vapours.

Fire may cause evolution of:

Oxides of phosphorus, nitrogen oxides


Special protective equipment for firefightersIn the event of fire, wear self-contained breathing apparatus.

Further informationPrevent fire extinguishing water from contaminating surface water or the ground water system.

Suppress (knock down) gases/vapours/mists with a water spray jet.



SAFETY DATA SHEET





Page 3 of 8

Advice for non-emergency personnel: Avoid inhalation of dusts. Evacuate the danger area,

observe emergency procedures, consult an expert.

Advice for emergency responders: Protective equipment see section 8.




Cover drains. Collect, bind, and pump off spills.

Observe possible material restrictions (see sections 7 and 10).

Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.

6.4 Reference to other sections

Indications about waste treatment see section 13.




Hygiene measuresChange contaminated clothing. Wash hands after working with substance.


Storage conditionsTightly closed. Dry.


7.3 Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated.



Contains no substances with occupational exposure limit values.


Engineering measures

Technical measures and appropriate working operations should be given priority over the use of

personal protective equipment.

See section 7.1.

Individual protection measures

Protective clothing needs to be selected specifically for the workplace, depending on

concentrations and quantities of the hazardous substances handled. The chemical resistance of

the protective equipment should be enquired at the respective supplier.

Eye/face protectionSafety glasses

Hand protection

full contact:

SAFETY DATA SHEET





Page 4 of 8

Glove material: Nitrile rubber

Glove thickness: 0.11 mm

Break through time: > 480 min

splash contact:




The protective gloves to be used must comply with the specifications of EC Directive

89/686/EEC and the related standard EN374, for example KCL 741 Dermatril® L (full contact),

KCL 741 Dermatril® L (splash contact).

The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374

with samples of the recommended glove types.

This recommendation applies only to the product stated in the safety data sheet, supplied by us

and for the designated use. When dissolving in or mixing with other substances and under

conditions deviating from those stated in EN374 please contact the supplier of CE-approved

gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Respiratory protectionrequired when dusts are generated.

Recommended Filter type: Filter P 1 (acc. to DIN 3181) for solid particles of inert substances

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective

devices are carried out according to the instructions of the producer. These measures have to be

properly documented.

Environmental exposure controls




Form solid

Colour white

Odour stinging

Odour Threshold No information available.

pH 7.6 - 8.2

at 100 g/l

20 °C

Melting point (decomposition)

Boiling point/boiling range not applicable

Flash point does not flash



Lower explosion limit not applicable

SAFETY DATA SHEET





Page 5 of 8

Upper explosion limit not applicable

Vapour pressure No information available.


Density 1.619 g/cm³

at 20 °C


Water solubility 690 g/l

at 20 °C

Partition coefficient: n-

octanol/water

log Pow: -2.85

(calculated)

(Lit.) Bioaccumulation is not expected.


Decomposition temperature > 100 °C




9.2 Other data

Ignition temperature not combustible

Bulk density ca.800 - 1,000 kg/m³


10.1 Reactivity

See section 10.3


The product is chemically stable under standard ambient conditions (room temperature) .


Risk of explosion with:

sodium hypochlorite


Strong heating.


no information available



SAFETY DATA SHEET





Page 6 of 8


11.1 Information on toxicological effects

Acute oral toxicityLD50 rat: 6,500 mg/kg (IUCLID)

Acute inhalation toxicityThis information is not available.

Acute dermal toxicityLD50 rabbit: > 7,950 mg/kg (IUCLID)

Skin irritationThis information is not available.

Eye irritationThis information is not available.






Specific target organ toxicity - single exposureThis information is not available.




After uptake of large quantities:

Diarrhoea, disturbed electrolyte balance.

The following applies to ammonium salts in general: after swallowing: local irritation symptoms,

nausea, vomiting, diarrhoea. Systemic effect: after the uptake of very large qantities: drop in

blood pressure, collapse, CNS disorders, spasms, narcotic conditions, respiratory paralysis,

haemolysis.

Handle in accordance with good industrial hygiene and safety practice.


12.1 Toxicity

Toxicity to fishLC50 Pimephales promelas (fathead minnow): 155 mg/l; 96 h (IUCLID)


Biodegradability

The methods for determining the biological degradability are not applicable to inorganic

substances.

SAFETY DATA SHEET





Page 7 of 8


Partition coefficient: n-octanol/waterlog Pow: -2.85

(calculated)




12.5 Results of PBT and vPvB assessment

Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No

1907/2006, Annex XIII.


Discharge into the environment must be avoided.


Waste treatment methodsWaste material must be disposed of in accordance with the Directive on waste 2008/98/EC as

well as other national and local regulations. Leave chemicals in original containers. No mixing

with other waste. Handle uncleaned containers like the product itself.

See www.retrologistik.com for processes regarding the return of chemicals and containers, or

contact us there if you have further questions.



14.1 - 14.6 Not classified as dangerous in the meaning of transport

regulations.


Not relevant



regulations.



regulations.

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

Not relevant




Storage class 10 - 13


A Chemical Safety Assessment has been carried out according to regulation (EC) No.

1907/2006 (REACH) for this substance.

SAFETY DATA SHEET





Page 8 of 8


Training advice

Provide adequate information, instruction and training for operators.

Labelling (67/548/EEC or 1999/45/EC)

The product does not need to be labelled in accordance with EC directives or respective national

laws.




SAFETY DATA SHEET




Page 1 of 12




Product name Potassium dihydrogen phosphate for analysis EMSURE® ISO






CAS-No. 7778-77-0








India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6


number





SAFETY DATA SHEET





Page 2 of 12

2.2 Label elements


Precautionary statements

Prevention

P260 Do not breathe dust.


2.3 Other hazards

None known.


3.1 Substance

Formula KH₂PO₄ H₂KO₄P (Hill)

EC-No. 231-913-4



1907/2006.

3.2 Mixture

Not applicable




In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/

shower.

After eye contact: rinse out with plenty of water. Remove contact lenses.


SAFETY DATA SHEET





Page 3 of 12


irritant effects, gastric pain, Diarrhoea, Nausea, Vomiting, Discomfort





Suitable extinguishing media

Use extinguishing measures that are appropriate to local circumstances and the surrounding

environment.

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.


Not combustible.



Oxides of phosphorus


Special protective equipment for firefighters

In the event of fire, wear self-contained breathing apparatus.

Further information

Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing

water from contaminating surface water or the ground water system.








SAFETY DATA SHEET





Page 4 of 12









Advice on safe handling

Observe label precautions.

Hygiene measures

Change contaminated clothing. Wash hands after working with substance.


Storage conditions

Tightly closed. Dry.












See section 7.1.

SAFETY DATA SHEET





Page 5 of 12





Eye/face protection

Safety glasses

Hand protection

full contact:




splash contact:









This recommendation applies only to the product stated in the safety data sheet<(>,<)> supplied

by us and for the designated use. When dissolving in or mixing with other substances and under



Respiratory protection

required when dusts are generated.







SAFETY DATA SHEET





Page 6 of 12



Form solid

Colour colourless

Odour odourless

Odour Threshold Not applicable

pH 4.2 - 4.6

at 20 g/l

20 °C

Melting point ca. 253 °C

(decomposition)

Boiling point/boiling range Not applicable, (decomposition)




Lower explosion limit Not applicable

Upper explosion limit Not applicable



Density 2.33 g/cm3

at 21.5 °C

Method: Tested according to Annex V of Directive 67/548/EEC.

SAFETY DATA SHEET





Page 7 of 12



at 20.0 °C

Method: Tested according to Annex V of Directive 67/548/EEC.

soluble


octanol/water







9.2 Other data


Bulk density ca.1,200 kg/m3

Particle size Mean particle size

< 0.045 mm


10.1 Reactivity

See section 10.3




Violent reactions possible with:

SAFETY DATA SHEET





Page 8 of 12

Strong oxidizing agents, Bases, acids


Strong heating (decomposition).







Acute oral toxicity

LDLO Rat: 4,640 mg/kg

Symptoms: Nausea, Vomiting, gastric pain, Diarrhoea, Discomfort

(RTECS)

LD50 Rat: > 2,000 mg/kg

OECD Test Guideline 420

The value is given in analogy to the following substances: dipotassium hydrogen phosphate

Acute inhalation toxicity

LC50 Rat: > 0.83 mg/l; 4 h ; dust/mist


The value is given in analogy to the following substances: (highest concentration to be prepared)

sodium dihydrogen phosphate

Acute dermal toxicity

LD50 Rabbit: > 4,640 mg/kg

(RTECS)

SAFETY DATA SHEET





Page 9 of 12

Skin irritation

Rabbit

Result: No skin irritation

Draize Test

(ECHA)

Eye irritation

Rabbit

Result: No eye irritation

Draize Test

(ECHA)

Sensitisation

Sensitisation test: Mouse

Result: Does not cause skin sensitisation.

Method: OECD Test Guideline 429

The value is given in analogy to the following substances: sodium dihydrogen phosphate

Germ cell mutagenicity

This information is not available.

Carcinogenicity


Reproductive toxicity


Teratogenicity


Specific target organ toxicity - single exposure


Specific target organ toxicity - repeated exposure


Aspiration hazard



Hazardous properties cannot be excluded but are unlikely when the product is handled

appropriately.

SAFETY DATA SHEET





Page 10 of 12

Inhalation of the dusts should be avoided as even inert dusts may impair respiratory organ

functions.



12.1 Toxicity

Toxicity to fish

LC0 Leuciscus idus (Golden orfe): ca. 900 mg/l; 48 h

(IUCLID)

Toxicity to bacteria

static test EC50 activated sludge: > 1,000 mg/l; 3 h


The value is given in analogy to the following substances: dipotassium hydrogen phosphate








PBT/vPvB assessment not available as chemical safety assessment not required/not conducted.


Additional ecological information

Depending on the concentration, phosphates may contribute to the eutrophication of water

supplies.


SAFETY DATA SHEET





Page 11 of 12


Waste treatment methods

Waste material must be disposed of in accordance with the national and local regulations. Leave

chemicals in original containers. No mixing with other waste. Handle uncleaned containers like

the product itself.






regulations.


Not relevant



regulations.



regulations.


Not relevant






SAFETY DATA SHEET





Page 12 of 12



Training advice


Labelling


Prevention

P260 Do not breathe dust.



The information contained herein is based on the present state of our knowledge. It characterises the product with

regard to the appropriate safety precautions. It does not represent a guarantee of any properties of the product.

MATERIAL SAFETY DATA SHEETMATERIAL SAFETY DATA SHEETMATERIAL SAFETY DATA SHEETMATERIAL SAFETY DATA SHEET

1111. . . . Product and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationMaterial nameMaterial nameMaterial nameMaterial name MAGNESIUM SULFATE HEPTAHYDRATEMAGNESIUM SULFATE HEPTAHYDRATEMAGNESIUM SULFATE HEPTAHYDRATEMAGNESIUM SULFATE HEPTAHYDRATEVersion #Version #Version #Version # 02Revision dateRevision dateRevision dateRevision date 08-29-2011CAS #CAS #CAS #CAS # 10034-99-8Product CodesProduct CodesProduct CodesProduct Codes J.T.Baker: 2500, 2504, 2505J.T.Baker: 2500, 2504, 2505J.T.Baker: 2500, 2504, 2505J.T.Baker: 2500, 2504, 2505

Macron: 26806, 4200, 5099, 5691, 6046, 6066, 7778Macron: 26806, 4200, 5099, 5691, 6046, 6066, 7778Macron: 26806, 4200, 5099, 5691, 6046, 6066, 7778Macron: 26806, 4200, 5099, 5691, 6046, 6066, 7778Synonym(s)Synonym(s)Synonym(s)Synonym(s) Magnesium sulfate (1:1) heptahydrate; Epsom salts; sulfuric acid, magnesium salt (1:1),

heptahydrate; Magnesium sulfate, 7- hydrate

Customer ServiceCustomer ServiceCustomer ServiceCustomer Service 855-282-686724 Hour Emergency24 Hour Emergency24 Hour Emergency24 Hour Emergency 908-859-2151ChemtrecChemtrecChemtrecChemtrec 800-424-9300

ManufacturerManufacturerManufacturerManufacturerAddressAddressAddressAddress

Avantor Performance Materials, Inc.3477 Corporate Parkway

Center Valley, PA 18034US

Suite #200

2222. . . . Hazards IdentificationHazards IdentificationHazards IdentificationHazards IdentificationEmergency overviewEmergency overviewEmergency overviewEmergency overview CAUTION

Product dust may be irritating to eyes, skin and respiratory system.OSHA regulatory statusOSHA regulatory statusOSHA regulatory statusOSHA regulatory status This material is not considered hazardous by the OSHA Hazard Communication Standard, OSHA

29 CFR 1910.1200.

Potential health effectsPotential health effectsPotential health effectsPotential health effectsRoutes of exposureRoutes of exposureRoutes of exposureRoutes of exposure Inhalation. Skin contact. Eye contact. Ingestion.EyesEyesEyesEyes Dust or powder may irritate eye tissue. If irritation should occur, it is expected to be transient.SkinSkinSkinSkin Dust or powder may irritate the skin.InhalationInhalationInhalationInhalation Inhalation of dusts may cause respiratory irritation.IngestionIngestionIngestionIngestion Expected to be a low ingestion hazard. May cause temporary irritation of the throat, stomach, and

gastrointestinal tract.Chronic effectsChronic effectsChronic effectsChronic effects None known.Potential environmental effectsPotential environmental effectsPotential environmental effectsPotential environmental effects The product components are not classified as environmentally hazardous. However, this does not

exclude the possibility that large or frequent spills can have a harmful or damaging effect on theenvironment.

Non-hazardous componentsNon-hazardous componentsNon-hazardous componentsNon-hazardous components CAS #CAS #CAS #CAS # PercentPercentPercentPercent

3333. . . . Composition Composition Composition Composition / / / / Information on IngredientsInformation on IngredientsInformation on IngredientsInformation on Ingredients

10034-99-8 98 - 100MAGNESIUM SULFATE HEPTAHYDRATE

Composition commentsComposition commentsComposition commentsComposition comments CAS # 10034-99-8 can be described by the CAS # 7487-88-9.

4444. . . . First Aid MeasuresFirst Aid MeasuresFirst Aid MeasuresFirst Aid MeasuresFirst aid proceduresFirst aid proceduresFirst aid proceduresFirst aid procedures

Eye contactEye contactEye contactEye contact Any material that contacts the eye should be washed out immediately with water. If easy to do,remove contact lenses. Get medical attention if irritation develops and persists.

Skin contactSkin contactSkin contactSkin contact Wash off with soap and water. Get medical attention if irritation develops and persists.InhalationInhalationInhalationInhalation Move to fresh air. Treat symptomatically. Get medical attention if symptoms persist.

Material name: MAGNESIUM SULFATE HEPTAHYDRATEMSDS ID: M0234 Version #: 02 Revision date: 08-29-2011

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IngestionIngestionIngestionIngestion Seek medical advice.Notes to physicianNotes to physicianNotes to physicianNotes to physician Treat symptomatically.General adviceGeneral adviceGeneral adviceGeneral advice Ensure that medical personnel are aware of the material(s) involved, and take precautions to

protect themselves. Show this safety data sheet to the doctor in attendance.

5555. . . . Fire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFlammable propertiesFlammable propertiesFlammable propertiesFlammable properties This product is not flammable.

Extinguishing mediaExtinguishing mediaExtinguishing mediaExtinguishing mediaSuitable extinguishingSuitable extinguishingSuitable extinguishingSuitable extinguishingmediamediamediamedia

Use extinguishing measures that are appropriate to local circumstances and the surroundingenvironment.

Unsuitable extinguishingUnsuitable extinguishingUnsuitable extinguishingUnsuitable extinguishingmediamediamediamedia

None known.

Protection of firefightersProtection of firefightersProtection of firefightersProtection of firefightersProtective equipment andProtective equipment andProtective equipment andProtective equipment andprecautions for firefightersprecautions for firefightersprecautions for firefightersprecautions for firefighters

Firefighters should wear full protective gear. Wear full protective clothing, including helmet,self-contained positive pressure or pressure demand breathing apparatus, protective clothing andface mask.

Special protective equipment forSpecial protective equipment forSpecial protective equipment forSpecial protective equipment forfire-fightersfire-fightersfire-fightersfire-fighters

As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH(approved or equivalent) and full protective gear.

6666. . . . Accidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresPersonal precautionsPersonal precautionsPersonal precautionsPersonal precautions Keep unnecessary personnel away. Keep upwind. Ventilate the area. Avoid inhalation of dust

from the spilled material. Do not touch damaged containers or spilled material unless wearingappropriate protective clothing.

Environmental precautionsEnvironmental precautionsEnvironmental precautionsEnvironmental precautions Prevent further leakage or spillage if safe to do so.Methods for containmentMethods for containmentMethods for containmentMethods for containment If sweeping of a contaminated area is necessary use a dust suppressant agent which does not

react with the product. Prevent entry into waterways, sewer, basements or confined areas.Methods for cleaning upMethods for cleaning upMethods for cleaning upMethods for cleaning up Avoid dust formation.

Small Spills: Sweep up or vacuum up spillage and collect in suitable container for disposal.

Large Spills: Collect dust or particulates using a vacuum cleaner with a HEPA filter. Reduceairborne dust and prevent scattering by moistening with water.

Never return spills in original containers for re-use. Clean contaminated surface thoroughly. Cleanup in accordance with all applicable regulations.

7777. . . . Handling and StorageHandling and StorageHandling and StorageHandling and StorageHandlingHandlingHandlingHandling Keep formation of airborne dusts to a minimum. Avoid breathing dust. Avoid contact with eyes,

skin, and clothing. Use only with adequate ventilation. Wash thoroughly after handling. SeeSection 8 of the MSDS for Personal Protective Equipment.

StorageStorageStorageStorage Keep container tightly closed. Store in a well-ventilated place.

8888. . . . Exposure Controls Exposure Controls Exposure Controls Exposure Controls / / / / Personal ProtectionPersonal ProtectionPersonal ProtectionPersonal ProtectionEngineering controlsEngineering controlsEngineering controlsEngineering controls Ventilation should be sufficient to effectively remove and prevent buildup of any dusts or fumes

that may be generated during handling or thermal processing. If engineering measures are notsufficient to maintain concentrations of dust particulates below the OEL, suitable respiratoryprotection must be worn.

Personal protective equipmentPersonal protective equipmentPersonal protective equipmentPersonal protective equipmentEye / face protectionEye / face protectionEye / face protectionEye / face protection Use tight fitting goggles if dust is generated.Skin protectionSkin protectionSkin protectionSkin protection Wear appropriate clothing to prevent repeated or prolonged skin contact.Respiratory protectionRespiratory protectionRespiratory protectionRespiratory protection Wear respirator if there is dust formation.General hygeineGeneral hygeineGeneral hygeineGeneral hygeineconsiderationsconsiderationsconsiderationsconsiderations

Provide eyewash station and safety shower. Always observe good personal hygiene measures,such as washing after handling the material and before eating, drinking, and/or smoking.Routinely wash work clothing and protective equipment to remove contaminants.


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9999. . . . Physical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesAppearanceAppearanceAppearanceAppearance Powder. Crystalline.

ColorColorColorColor Colorless to white.

OdorOdorOdorOdor Odorless.

Odor thresholdOdor thresholdOdor thresholdOdor threshold Not available.

Physical statePhysical statePhysical statePhysical state Solid.

FormFormFormForm Crystalline powder.

Flash pointFlash pointFlash pointFlash point Not available.

Evaporation rateEvaporation rateEvaporation rateEvaporation rate Not available.

Flammability limits in air, upper,Flammability limits in air, upper,Flammability limits in air, upper,Flammability limits in air, upper,% by volume% by volume% by volume% by volume

Not available.

Flammability limits in air, lower,Flammability limits in air, lower,Flammability limits in air, lower,Flammability limits in air, lower,% by volume% by volume% by volume% by volume

Not available.

Vapor densityVapor densityVapor densityVapor density Not available.

Specific gravitySpecific gravitySpecific gravitySpecific gravity 1.67

Relative densityRelative densityRelative densityRelative density Not available.

Solubility (water)Solubility (water)Solubility (water)Solubility (water) Soluble

Partition coefficientPartition coefficientPartition coefficientPartition coefficient(n-octanol/water)(n-octanol/water)(n-octanol/water)(n-octanol/water)

Not available

Auto-ignition temperatureAuto-ignition temperatureAuto-ignition temperatureAuto-ignition temperature Not available.

Molecular weightMolecular weightMolecular weightMolecular weight 246.47 g/mol

Molecular formulaMolecular formulaMolecular formulaMolecular formula Mg-O4-S.7H2O

10101010. . . . Chemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical stabilityChemical stabilityChemical stabilityChemical stability Stable under normal temperature conditions.Conditions to avoidConditions to avoidConditions to avoidConditions to avoid Incompatible materials.Incompatible materialsIncompatible materialsIncompatible materialsIncompatible materials Strong oxidizing agents.Hazardous decompositionHazardous decompositionHazardous decompositionHazardous decompositionproductsproductsproductsproducts

Sulfur oxides. May include oxides of Magnesium.

Possibility of hazardousPossibility of hazardousPossibility of hazardousPossibility of hazardousreactionsreactionsreactionsreactions

Hazardous polymerization does not occur.

11111111. . . . Toxicological InformationToxicological InformationToxicological InformationToxicological InformationSensitizationSensitizationSensitizationSensitization Not a skin sensitizer.

Acute effectsAcute effectsAcute effectsAcute effects Low hazard for usual industrial or commercial handling.

Local effectsLocal effectsLocal effectsLocal effects May cause eye irritation. May cause skin irritation. May cause irritation to the respiratory system.

Chronic effectsChronic effectsChronic effectsChronic effects None known.

CarcinogenicityCarcinogenicityCarcinogenicityCarcinogenicity This product is not considered to be a carcinogen by IARC, ACGIH, NTP, or OSHA.

Skin corrosion/irritationSkin corrosion/irritationSkin corrosion/irritationSkin corrosion/irritation May irritate and cause redness and pain.

EpidemiologyEpidemiologyEpidemiologyEpidemiology No epidemiological data is available for this product.

MutagenicityMutagenicityMutagenicityMutagenicity No data available to indicate product or any components present at greater than 0.1% aremutagenic or genotoxic.

Neurological effectsNeurological effectsNeurological effectsNeurological effects None known.

Reproductive effectsReproductive effectsReproductive effectsReproductive effects Contains no ingredient listed as toxic to reproduction

TeratogenicityTeratogenicityTeratogenicityTeratogenicity No data available to indicate product or any components present at greater than 0.1% may causebirth defects.

Symptoms and targetSymptoms and targetSymptoms and targetSymptoms and targetorgansorgansorgansorgans

Mild eye irritation.


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Ecotoxicological dataEcotoxicological dataEcotoxicological dataEcotoxicological data

12121212. . . . Ecological InformationEcological InformationEcological InformationEcological Information

ProductProductProductProduct Test ResultsTest ResultsTest ResultsTest Results

LC50 Fathead minnow (Pimephales promelas): 2610 mg/l96.00 hours

MAGNESIUM SULFATE HEPTAHYDRATE (10034-99-8)

EcotoxicityEcotoxicityEcotoxicityEcotoxicity This product has no known eco-toxicological effects.

Environmental effectsEnvironmental effectsEnvironmental effectsEnvironmental effects Ecological injuries are not known or expected under normal use. An environmental hazard cannotbe excluded in the event of unprofessional handling or disposal.

Aquatic toxicityAquatic toxicityAquatic toxicityAquatic toxicity This material is not expected to be harmful to aquatic life.

Persistence andPersistence andPersistence andPersistence anddegradabilitydegradabilitydegradabilitydegradability

The product is not expected to be biodegradable.


Not available

13131313. . . . Disposal ConsiderationsDisposal ConsiderationsDisposal ConsiderationsDisposal ConsiderationsDisposal instructionsDisposal instructionsDisposal instructionsDisposal instructions Dispose of contents/container in accordance with local/regional/national/international regulations.

Incinerate the material under controlled conditions in an approved incinerator.Contaminated packagingContaminated packagingContaminated packagingContaminated packaging Offer rinsed packaging material to local recycling facilities. Since emptied containers retain

product residue, follow label warnings even after container is emptied.

14141414. . . . Transport InformationTransport InformationTransport InformationTransport InformationDOTDOTDOTDOTNot regulated as dangerous goods.

IATAIATAIATAIATANot regulated as dangerous goods.

IMDGIMDGIMDGIMDGNot regulated as dangerous goods.

15151515. . . . Regulatory InformationRegulatory InformationRegulatory InformationRegulatory InformationUS federal regulationsUS federal regulationsUS federal regulationsUS federal regulations This product is not known to be a "Hazardous Chemical" as defined by the OSHA Hazard

Communication Standard, 29 CFR 1910.1200.

This product is not listed on the U.S. EPA TSCA Inventory. Under TSCA, hydrates areconsidered mixtures of their anhydrous salt and water. Accordingly, the anhydrous form issubject to TSCA reporting requirements.

CERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityNone

Superfund Amendments and Reauthorization Act of 1986 (SARA)Superfund Amendments and Reauthorization Act of 1986 (SARA)Superfund Amendments and Reauthorization Act of 1986 (SARA)Superfund Amendments and Reauthorization Act of 1986 (SARA)Hazard categoriesHazard categoriesHazard categoriesHazard categories Immediate Hazard - No

Delayed Hazard - NoFire Hazard - NoPressure Hazard - NoReactivity Hazard - No

Section 311 hazardousSection 311 hazardousSection 311 hazardousSection 311 hazardouschemicalchemicalchemicalchemical

No

Food and Drug AdministrationFood and Drug AdministrationFood and Drug AdministrationFood and Drug Administration(FDA)(FDA)(FDA)(FDA)

Total food additiveDirect food additiveGRAS food additive

Inventory statusInventory statusInventory statusInventory statusCountryCountryCountryCountry((((ssss) ) ) ) or regionor regionor regionor region Inventory nameInventory nameInventory nameInventory name On inventory On inventory On inventory On inventory ((((yesyesyesyes////nononono)*)*)*)*

YesAustralia Australian Inventory of Chemical Substances (AICS)YesCanada Domestic Substances List (DSL)


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CountryCountryCountryCountry((((ssss) ) ) ) or regionor regionor regionor region Inventory nameInventory nameInventory nameInventory name On inventory On inventory On inventory On inventory ((((yesyesyesyes////nononono)*)*)*)*NoCanada Non-Domestic Substances List (NDSL)

YesChina Inventory of Existing Chemical Substances in China (IECSC)NoEurope European Inventory of Existing Commercial Chemical

Substances (EINECS)NoEurope European List of Notified Chemical Substances (ELINCS)

YesJapan Inventory of Existing and New Chemical Substances (ENCS)NoKorea Existing Chemicals List (ECL)

YesNew Zealand New Zealand InventoryYesPhilippines Philippine Inventory of Chemicals and Chemical Substances

(PICCS)NoUnited States & Puerto Rico Toxic Substances Control Act (TSCA) Inventory

*A "Yes" indicates that all components of this product comply with the inventory requirements administered by the governing country(s)

State regulationsState regulationsState regulationsState regulations This product does not contain a chemical known to the State of California to cause cancer, birthdefects or other reproductive harm.

Saf-T-DataSaf-T-DataSaf-T-DataSaf-T-Data Health: 1 - SlightFlammability: 0 - NoneReactivity: 1 - SlightContact: 1 - SlightLab Protective Equip: C - GOGGLES; LAB COAT; PROPER GLOVESStorage Color Code: G - Green (General Storage)

16161616. . . . Labeling InfoLabeling InfoLabeling InfoLabeling InfoLabel Hazard WarningLabel Hazard WarningLabel Hazard WarningLabel Hazard Warning CAUTION

Product dust may be irritating to eyes, skin and respiratory system.Label PrecautionsLabel PrecautionsLabel PrecautionsLabel Precautions Avoid breathing dust. Avoid contact with eyes, skin, and clothing. Use only with adequate

ventilation. Wash thoroughly after handling. Keep container closed.Label First AidLabel First AidLabel First AidLabel First Aid Immediately flush eyes with plenty of water for at least 15 minutes. Flush skin thoroughly with

water. If gas/fume/vapor/dust/mist from the material is inhaled, remove the affected personimmediately to fresh air. Get medical attention if symptoms persist. If ingestion of a large amountdoes occur, call a poison control center immediately.

17171717. . . . Other InformationOther InformationOther InformationOther InformationNFPA ratingsNFPA ratingsNFPA ratingsNFPA ratings Health: 1

Flammability: 0Instability: 0


MSDS US COV

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DisclaimerDisclaimerDisclaimerDisclaimer THE INFORMATION PRESENTED IN THIS MATERIAL SAFETY DATA SHEET (MSDS/SDS)WAS PREPARED BY TECHNICAL PERSONNEL BASED ON DATA THAT THEY BELIEVE INTHEIR GOOD FAITH JUDGMENT IS ACCURATE. HOWEVER, THE INFORMATION PROVIDEDHEREIN IS PROVIDED “AS IS,” AND AVANTOR PERFORMANCE MATERIALS MAKES ANDGIVES NO REPRESENTATIONS OR WARRANTIES WHATSOEVER, AND EXPRESSLYDISCLAIMS ALL WARRANTIES REGARDING SUCH INFORMATION AND THE PRODUCT TOWHICH IT RELATES, WHETHER EXPRESS, IMPLIED, OR STATUTORY, INCLUDINGWITHOUT LIMITATION, WARRANTIES OF ACCURACY, COMPLETENESS,MERCHANTABILITY, NON-INFRINGEMENT, PERFORMANCE, SAFETY, SUITABILITY,STABILITY, AND FITNESS FOR A PARTICULAR PURPOSE, AND ANY WARRANTIES ARISINGFROM COURSE OF DEALING, COURSE OF PERFORMANCE, OR USAGE OF TRADE. THISMSDS/SDS IS INTENDED ONLY AS A GUIDE TO THE APPROPRIATE PRECAUTIONARYHANDLING OF THE MATERIAL BY A PROPERLY TRAINED PERSON USING THIS PRODUCT,AND IS NOT INTENDED TO BE COMPREHENSIVE AS TO THE MANNER AND CONDITIONSOF USE, HANDLING, STORAGE, OR DISPOSAL OF THE PRODUCT. INDIVIDUALSRECEIVING THIS MSDS/SDS MUST ALWAYS EXERCISE THEIR OWN INDEPENDENTJUDGMENT IN DETERMINING THE APPROPRIATENESS OF SUCH ISSUES. ACCORDINGLY,AVANTOR PERFORMANCE MATERIALS ASSUMES NO LIABILITY WHATSOEVER FOR THEUSE OF OR RELIANCE UPON THIS INFORMATION. NO SUGGESTIONS FOR USE AREINTENDED AS, AND NOTHING HEREIN SHALL BE CONSTRUED AS, A RECOMMENDATIONTO INFRINGE ANY EXISTING PATENTS OR TO VIOLATE ANY FEDERAL, STATE, LOCAL, ORFOREIGN LAWS. AVANTOR PERFORMANCE MATERIALS REMINDS YOU THAT IT IS YOURLEGAL DUTY TO MAKE ALL INFORMATION IN THIS MSDS/SDS AVAILABLE TO YOUREMPLOYEES.

Issue dateIssue dateIssue dateIssue date 08-29-2011


MSDS US COV

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SAFETY DATA SHEET




Page 1 of 12




Product name D(+)-Glucose anhydrous for cell culture media






CAS-No. 50-99-7


Identified uses Pharmaceutical production






India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6


number


SAFETY DATA SHEET





Page 2 of 12




2.2 Label elements



2.3 Other hazards

None known.


3.1 Substance

Formula C₆H₁₂O₆ (Hill)

EC-No. 200-075-1



1907/2006.

3.2 Mixture

Not applicable




SAFETY DATA SHEET





Page 3 of 12


shower.




We have no description of any toxic symptoms.






Water, Foam, Carbon dioxide (CO2), Dry powder




Combustible.

Development of hazardous combustion gases or vapours possible in the event of fire.

Risk of dust explosion.




Further information

Prevent fire extinguishing water from contaminating surface water or the ground water system.



SAFETY DATA SHEET





Page 4 of 12






Do not let product enter drains.


Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see

sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation

of dusts.







Hygiene measures



Storage conditions





SAFETY DATA SHEET





Page 5 of 12








See section 7.1.





Eye/face protection

Safety glasses

Hand protection

full contact:



Break through time: 480 min

splash contact:



Break through time: 480 min






SAFETY DATA SHEET





Page 6 of 12















Form solid

Colour colourless

Odour odourless


pH No information available.


Boiling point No information available.

Flash point No information available.

SAFETY DATA SHEET





Page 7 of 12



Lower explosion limit No information available.

Upper explosion limit No information available.



Density No information available.


Water solubility ca.470 g/l

at 20 °C


octanol/water

log Pow: -3.24

(experimental)







9.2 Other data

SAFETY DATA SHEET





Page 8 of 12

Ignition temperature ca. 500 °C

Bulk density ca.630 kg/m3


10.1 Reactivity

Risk of dust explosion.





halogenates, nitrates, permanganates, Strong oxidizing agents









Acute oral toxicity

LD50 Rat: 25,800 mg/kg

(RTECS)



SAFETY DATA SHEET





Page 9 of 12



Skin irritation


Eye irritation


Sensitisation




Carcinogenicity




Teratogenicity






Aspiration hazard



Our own experience has provided no indication of any hazardous potential.

Substance which occurs in the human body under physiological conditions.

Substances which occur in nature



12.1 Toxicity

SAFETY DATA SHEET





Page 10 of 12

Toxicity to fish

LC0 fish: 60,000 mg/l

(External MSDS)


Biodegradability

48 %; 5 d

OECD Test Guideline 301D

Readily biodegradable



log Pow: -3.24

(experimental)









SAFETY DATA SHEET





Page 11 of 12





the product itself.






regulations.


Not relevant



regulations.



regulations.


Not relevant





SAFETY DATA SHEET





Page 12 of 12

15.2 Chemical safety assessment



Training advice









Page 1 of 8




Product name IPTG, Animal-Free, High Purity






CAS-No. 367-93-1


Identified uses Biochemical research/analysis




Company Merck Life Science Private Limited * Shiv Sagar Estate 'A', Dr. Annie

Besant Road, Worli Mumbai - 400 018 India * Tel:0091 22 66609000

Responsible Department Quality Assurance * Merck Specialities Private Limited *


Tel : +91-2267863131-6


number





2.2 Label elements



2.3 Other hazards

None known.


3.1 Substance

Formula C₉H₁₈O₅S (Hill)

EC-No. 206-703-0


SAFETY DATA SHEET





Page 2 of 8


1907/2006

3.2 Mixture

Not applicable





shower.









Suitable extinguishing mediaWater, Carbon dioxide (CO2), Foam, Dry powder



Combustible.



Sulphur oxides



Further informationSuppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing









SAFETY DATA SHEET





Page 3 of 8












Storage conditionsTightly closed. Dry. Protected from light.











See section 7.1.






Hand protection

full contact:




splash contact:




SAFETY DATA SHEET





Page 4 of 8

















Form solid

Colour white

Odour odourless



Melting point 109 - 111 °C


Flash point > 110 °C









SAFETY DATA SHEET





Page 5 of 8


at 20 °C


octanol/water

log Pow: -1.26

(experimental)







9.2 Other data



10.1 Reactivity

The following applies in general to flammable organic substances and mixtures: in

correspondingly fine distribution, when whirled up a dust explosion potential may generally be

assumed.


Sensitivity to light



Strong oxidizing agents









Acute oral toxicityThis information is not available.



SAFETY DATA SHEET





Page 6 of 8

Skin irritationThis information is not available.

Eye irritationThis information is not available.

Sensitisation

Sensitisation possible in predisposed persons.










appropriately.



12.1 Toxicity





Partition coefficient: n-octanol/waterlog Pow: -1.26

(experimental)








SAFETY DATA SHEET





Page 7 of 8


Waste treatment methodsWaste material must be disposed of in accordance with the national and local regulations. Leave


the product itself.






regulations.


Not relevant



regulations.



regulations.


Not relevant








Training advice




laws.


SAFETY DATA SHEET





Page 8 of 8




Sigma - A6426 Page 1 of 6

SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006 Version 5.0 Revision Date 07.01.2013

Print Date 18.03.2013

1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

1.1 Product identifiers Product name : Antifoam 204

Product Number : A6426 Brand : Sigma


Identified uses : Laboratory chemicals, Manufacture of substances


Company : Sigma-Aldrich Company Ltd. The Old Brickyard NEW ROAD, GILLINGHAM Dorset SP8 4XT UNITED KINGDOM

Telephone : +44 (0)1747 833000 Fax : +44 (0)1747 833313 E-mail address : [email protected]


Emergency Phone # : +44 (0)1747 833100

2. HAZARDS IDENTIFICATION

2.1 Classification of the substance or mixture Not a hazardous substance or mixture according to Regulation (EC) No. 1272/2008. This substance is not classified as dangerous according to Directive 67/548/EEC.

2.2 Label elements

The product does not need to be labelled in accordance with EC directives or respective national laws.

2.3 Other hazards - none

3. COMPOSITION/INFORMATION ON INGREDIENTS

3.1 Substances

4. FIRST AID MEASURES


If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration.

In case of skin contact Wash off with soap and plenty of water.

In case of eye contact Flush eyes with water as a precaution.

If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water.


4.2 Most important symptoms and effects, both acute and delayed To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

4.3 Indication of any immediate medical attention and special treatment needed no data available

5. FIREFIGHTING MEASURES


Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2 Special hazards arising from the substance or mixture Nature of decomposition products not known.

5.3 Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary.

5.4 Further information no data available

6. ACCIDENTAL RELEASE MEASURES

6.1 Personal precautions, protective equipment and emergency procedures Avoid breathing vapors, mist or gas.

6.2 Environmental precautions Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Keep in suitable, closed containers for disposal.

6.4 Reference to other sections For disposal see section 13.

7. HANDLING AND STORAGE

7.1 Precautions for safe handling no data available

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

7.3 Specific end use(s) no data available

8. EXPOSURE CONTROLS/PERSONAL PROTECTION


Components with workplace control parameters Contains no substances with occupational exposure limit values.


Appropriate engineering controls General industrial hygiene practice.

Personal protective equipment

Eye/face protection Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of


contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Impervious clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Respiratory protection not required. For nuisance exposures use type OV/AG (US) or type ABEK (EU EN 14387) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

9. PHYSICAL AND CHEMICAL PROPERTIES


a) Appearance Form: viscous liquid Colour: colourless

b) Odour no data available

c) Odour Threshold no data available

d) pH no data available

e) Melting point/freezing point

no data available

f) Initial boiling point and boiling range

no data available

g) Flash point no data available

h) Evaporation rate no data available

i) Flammability (solid, gas) no data available

j) Upper/lower flammability or explosive limits

no data available

k) Vapour pressure no data available

l) Vapour density no data available

m) Relative density 1.01 g/cm3 at 25 °C

n) Water solubility no data available

o) Partition coefficient: n-octanol/water

no data available

p) Auto-ignition temperature

no data available

q) Decomposition temperature

no data available

r) Viscosity no data available

s) Explosive properties no data available

t) Oxidizing properties no data available

9.2 Other safety information no data available

10. STABILITY AND REACTIVITY

10.1 Reactivity no data available


10.2 Chemical stability no data available

10.3 Possibility of hazardous reactions no data available

10.4 Conditions to avoid no data available

10.5 Incompatible materials Strong oxidizing agents

10.6 Hazardous decomposition products Other decomposition products - no data available

11. TOXICOLOGICAL INFORMATION


Acute toxicity no data available

Skin corrosion/irritation no data available

Serious eye damage/eye irritation no data available

Respiratory or skin sensitization no data available

Germ cell mutagenicity no data available

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.


no data available

Specific target organ toxicity - single exposure no data available

Specific target organ toxicity - repeated exposure no data available

Aspiration hazard no data available

Potential health effects

Inhalation May be harmful if inhaled. May cause respiratory tract irritation. Ingestion May be harmful if swallowed. Skin May be harmful if absorbed through skin. May cause skin irritation. Eyes May cause eye irritation.

Signs and Symptoms of Exposure To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

Additional Information RTECS: Not available

12. ECOLOGICAL INFORMATION

12.1 Toxicity no data available


12.2 Persistence and degradability no data available

12.3 Bioaccumulative potential no data available

12.4 Mobility in soil no data available

12.5 Results of PBT and vPvB assessment no data available

12.6 Other adverse effects no data available

13. DISPOSAL CONSIDERATIONS

13.1 Waste treatment methods

Product Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging Dispose of as unused product.

14. TRANSPORT INFORMATION

14.1 UN number ADR/RID: - IMDG: - IATA: -

14.2 UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

14.3 Transport hazard class(es) ADR/RID: - IMDG: - IATA: -

14.4 Packaging group ADR/RID: - IMDG: - IATA: -

14.5 Environmental hazards ADR/RID: no IMDG Marine Pollutant: no IATA: no

14.6 Special precautions for user no data available

15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture no data available

15.2 Chemical Safety Assessment no data available

16. OTHER INFORMATION

Further information Copyright 2013 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.


Sigma - 60615 Page 1 of 7



Print Date 25.05.2018 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers Product name : Kanamycin sulfate

Product Number : 60615 Brand : Sigma REACH No. : A registration number is not available for this substance as the substance

or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

CAS-No. : 70560-51-9




Company : Sigma-Aldrich Chemical Pvt Limited Industrial Area, Anekal Taluka Plot No 12, 12 Bommasandra - Jigani Link Road 560100 BANGALORE INDIA


Emergency Phone # : +91 98802 05043

SECTION 2: Hazards identification


Classification according to Regulation (EC) No 1272/2008 Reproductive toxicity (Category 1B), H360


2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram

Signal word Danger Hazard statement(s) H360 May damage fertility or the unborn child. Precautionary statement(s) P201 Obtain special instructions before use. P308 + P313 IF exposed or concerned: Get medical advice/ attention. Supplemental Hazard Statements

none


Restricted to professional users.

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances CAS-No. : 70560-51-9 Hazardous ingredients according to Regulation (EC) No 1272/2008

Component Classification Concentration

Kanamycin sulfate, mixture of the components A, B and C

CAS-No.

70560-51-9

Repr. 1B; H360 <= 100 %


SECTION 4: First aid measures


General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Consult a physician.


If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed No data available

SECTION 5: Firefighting measures




5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information No data available


SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.


SECTION 7: Handling and storage

7.1 Precautions for safe handling Avoid formation of dust and aerosols.Avoid exposure - obtain special instructions before use. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection



Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.


Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm


Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (EN 143) respirator cartridges as a backup to engineering controls. If th full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties


a) Appearance Form: powder Colour: white

b) Odour No data available

c) Odour Threshold No data available

d) pH No data available


No data available


No data available

g) Flash point No data available

h) Evaporation rate No data available

i) Flammability (solid, gas) No data available


No data available

k) Vapour pressure No data available

l) Vapour density No data available

m) Relative density No data available

n) Water solubility No data available


No data available


No data available


No data available

r) Viscosity No data available

s) Explosive properties No data available


t) Oxidizing properties No data available

9.2 Other safety information No data available

SECTION 10: Stability and reactivity

10.1 Reactivity No data available

10.2 Chemical stability Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions No data available

10.4 Conditions to avoid No data available


10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Nature of decomposition products not known. Other decomposition products - No data available In the event of fire: see section 5

SECTION 11: Toxicological information


Acute toxicity No data availableKanamycin sulfate, mixture of the components A, B and C

Skin corrosion/irritation No data available(Kanamycin sulfate, mixture of the components A, B and C)

Serious eye damage/eye irritation No data available(Kanamycin sulfate, mixture of the components A, B and C)

Respiratory or skin sensitisation No data available(Kanamycin sulfate, mixture of the components A, B and C)

Germ cell mutagenicity No data available(Kanamycin sulfate, mixture of the components A, B and C)

Carcinogenicity



Presumed human reproductive toxicant(Kanamycin sulfate, mixture of the components A, B and C)

Specific target organ toxicity - single exposure No data available(Kanamycin sulfate, mixture of the components A, B and C)

Specific target organ toxicity - repeated exposure No data available

Aspiration hazard No data available(Kanamycin sulfate, mixture of the components A, B and C)

Additional Information RTECS: Not available


Aminoglycosides are associated with significant nephrotoxicity and/or ototoxicity.(Kanamycin sulfate, mixture of the components A, B and C)

SECTION 12: Ecological information

12.1 Toxicity No data available

12.2 Persistence and degradability No data available

12.3 Bioaccumulative potential No data available

12.4 Mobility in soil No data available(Kanamycin sulfate, mixture of the components A, B and C)

12.5 Results of PBT and vPvB assessment This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

12.6 Other adverse effects No data available

SECTION 13: Disposal considerations


Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chem scrubber.


SECTION 14: Transport information





14.5 Environmental hazards ADR/RID: no IMDG Marine pollutant: no IATA: no

14.6 Special precautions for user No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.2 Chemical safety assessment For this product a chemical safety assessment was not carried out


SECTION 16: Other information


H360 May damage fertility or the unborn child.


Page 1/7

Safety data sheetaccording to 1907/2006/EC, Article 31

Date Prepared: 24.03.2014 Revision: 08.01.2013

38.0.21

1 Identification of the substance/mixture and of the company/undertaking

· Product identifier· Trade name: Bacto Tryptone Peptone· Article number: 211705· Relevant identified uses of the substance or mixture and uses advised against· Sector of Use

SU3 Industrial uses: Uses of substances as such or in preparations at industrial sitesSU22 Professional uses: Public domain (administration, education, entertainment, services,craftsmen)SU20 Health servicesSU24 Scientific research and development

· Application of the substance / the mixtureIn-vitro DiagnosticsPreparation

· Details of the supplier of the safety data sheet· Manufacturer/Supplier:

BD Diagnostic Systems EuropeRegulatory Compliance DepartmentBecton Dickinson France11, rue Aristide Bergès38800 Le Pont de ClaixFranceTelephone: 33 (0) 476 68 36 36Email: [email protected]

· Further information obtainable from: Technical Service Representative· Emergency telephone number: Tel: 33 (0) 476 68 36 36

2 Hazards identification

· Classification of the substance or mixture· Classification according to Regulation (EC) No 1272/2008

The product is not classified according to the CLP regulation.

· Classification according to Directive 67/548/EEC or Directive 1999/45/ECThis product contains no hazardous constituents, or the concentration of all chemicalconstituents are below the regulatory threshold limits described by the Occupational Safetyand Health Administration Hazard Communication Standard or European Directive 67/548/EEC and 1999/45/EC.

· Information concerning particular hazards for human and environment:Not applicableThe product does not have to be labelled due to the calculation procedure of the "GeneralClassification guideline for preparations of the EU" in the latest valid version.

· Classification system:The classification is according to the latest editions of the EU-lists, and extended by companyand literature data.

(Contd. on page 2) EU

Page 2/7



Trade name: Bacto Tryptone Peptone

(Contd. of page 1)

38.0.21

· Label elements

· Labelling according to EU guidelines:Observe the general safety regulations when handling chemicalsThe product is not subject to identification regulations under EU Directives and the Ordinanceon Hazardous Materials (German GefStoffV).

· Other hazards· Results of PBT and vPvB assessment· PBT: Not applicable.· vPvB: Not applicable.

3 Composition/information on ingredients

· Chemical characterization: Mixtures· Description: Mixture consisting of the following components.

· Dangerous components: Void· Additional information For the wording of the listed risk phrases refer to section 15.

4 First aid measures

· Description of first aid measures· General information No special measures required.· After inhalation Seek medical treatment in case of complaints.· After skin contact Immediately wash with water and soap and rinse thoroughly.· After eye contact

Rinse opened eye for several minutes under running water. If symptoms persist, consult adoctor.

· After swallowing If symptoms persist consult doctor.· Information for doctor· Most important symptoms and effects, both acute and delayed

No further relevant information available.· Indication of any immediate medical attention and special treatment needed

No further relevant information available.

5 Firefighting measures

· Extinguishing media· Suitable extinguishing agents

CO2, powder or water spray. Fight larger fires with water spray or alcohol resistant foam.· Special hazards arising from the substance or mixture

No further relevant information available.(Contd. on page 3)

EU

Page 3/7




(Contd. of page 2)

38.0.21

· Advice for firefighters· Protective equipment: No special measures required.

6 Accidental release measures

· Personal precautions, protective equipment and emergency procedures Not required.· Environmental precautions: Wipe up with damp sponge or mop.· Methods and material for containment and cleaning up: No special measures required.· Reference to other sections No dangerous substances are released.

7 Handling and storage

· Handling· Precautions for safe handling No special measures required.· Information about fire - and explosion protection: No special measures required.

· Conditions for safe storage, including any incompatibilities· Storage· Requirements to be met by storerooms and receptacles: 2 - 25℃· Information about storage in one common storage facility:

Store away from oxidizing agents.· Further information about storage conditions:

Store in cool, dry conditions in well sealed receptacles.· Specific end use(s) No further relevant information available.

8 Exposure controls/personal protection

· Additional information about design of technical facilities: No further data; see item 7.

· Control parameters· Ingredients with limit values that require monitoring at the workplace:

The product does not contain any relevant quantities of materials with critical values thathave to be monitored at the workplace.

· Additional information: The lists valid during the making were used as basis.

· Exposure controls· Personal protective equipment· General protective and hygienic measures

The usual precautionary measures are to be adhered to when handling chemicals.· Respiratory protection: Not required.· Protection of hands:

Protective gloves.


Page 4/7




(Contd. of page 3)

38.0.21

· Eye protection: Safety glasses· Body protection: Protective work clothing.

9 Physical and chemical properties

· Information on basic physical and chemical properties· General Information· Appearance:

Form: Solid.Powder

Colour: Beige· Odour: Characteristic

· Change in conditionMelting point/Melting range: Not determinedBoiling point/Boiling range: Not determined

· Flash point: Not applicable

· Flammability (solid, gaseous) Product is not flammable.

· Danger of explosion: Product does not present an explosion hazard.

· Density: Not determined

· Solubility in / Miscibility withWater: Soluble

· Solvent content:Organic solvents: 0,0 %

Solids content: 100,0 %· Other information No further relevant information available.

10 Stability and reactivity

· Reactivity· Chemical stability· Thermal decomposition / conditions to be avoided:

No decomposition if used according to specifications.· Possibility of hazardous reactions No dangerous reactions known· Conditions to avoid No further relevant information available.· Incompatible materials: No further relevant information available.· Hazardous decomposition products: No dangerous decomposition products known

EU

(Contd. on page 5)

Page 5/7




(Contd. of page 4)

38.0.21

11 Toxicological information

· Information on toxicological effects· Acute toxicity:· Primary irritant effect:· on the skin: No irritant effect.· on the eye: No irritating effect.· Sensitization: No sensitizing effects known.· Additional toxicological information:

The product is not subject to classification according to the calculation method of the GeneralEU Classification Guidelines for Preparations as issued in the latest version.When used and handled according to specifications, the product does not have any harmfuleffects to our experience and the information provided to us.

12 Ecological information

· Toxicity· Aquatic toxicity: No further relevant information available.· Persistence and degradability No further relevant information available.· Behaviour in environmental systems:· Bioaccumulative potential No further relevant information available.· Mobility in soil No further relevant information available.· Ecotoxical effects:· Other information:

The ecological effects have not ben thoroughly investigated, but currently none have beenidentified.

· Additional ecological information:· General notes: Generally not hazardous for water.· Results of PBT and vPvB assessment· PBT: Not applicable.· vPvB: Not applicable.· Other adverse effects No further relevant information available.

13 Disposal considerations

· Waste treatment methods· Recommendation

Must be specially treated adhering to official regulations.Smaller quantities can be disposed of with household waste.

· Uncleaned packaging:· Recommendation: Disposal must be made according to official regulations.


Page 6/7




(Contd. of page 5)

38.0.21

· Recommended cleansing agents: Water, if necessary together with cleansing agents.

14 Transport information

· UN-Number· ADR, ADN, IMDG, IATA Void

· UN proper shipping name· ADR, ADN, IMDG, IATA Void

· Transport hazard class(es)

· ADR, ADN, IMDG, IATA· Class Void

· Packing group· ADR, IMDG, IATA Void

· Environmental hazards:· Marine pollutant: No

· Special precautions for user Not applicable.

· Transport in bulk according to Annex II ofMARPOL73/78 and the IBC Code Not applicable.

· UN "Model Regulation": -

15 Regulatory information

· Safety, health and environmental regulations/legislation specific for the substance ormixture

· Labelling according to EU guidelines:Observe the general safety regulations when handling chemicalsThe product is not subject to identification regulations under EU Directives and the Ordinanceon Hazardous Materials (German GefStoffV).

· Chemical safety assessment: A Chemical Safety Assessment has not been carried out.

16 Other informationDisclaimer:To the best of our knowledge, the information contained herein is accurate. However, neitherBD or any of its subsidiaries assums any liabilities whatsoever for the accuracy orcompleteness of the information contained herein. Final determination of suitability of anymaterial is the sole responsibility of the user. All materials may present unknown hazards andshould be used with caution. Although certain hazards described herein, we cannotguarantee that these are the only hazards that exist.


Page 7/7




(Contd. of page 6)

38.0.21

· Department issuing MSDS:Environmental, Health & SafetyCreated by Michael J. Spinazzola

· Contact: Technical Service Representative· Abbreviations and acronyms:

ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreementconcerning the International Carriage of Dangerous Goods by Road)IMDG: International Maritime Code for Dangerous GoodsIATA: International Air Transport AssociationGHS: Globally Harmonized System of Classification and Labelling of ChemicalsEINECS: European Inventory of Existing Commercial Chemical SubstancesELINCS: European List of Notified Chemical SubstancesCAS: Chemical Abstracts Service (division of the American Chemical Society)

EU

Page 1/7

Safety Data Sheetacc. to OSHA HCS

Date Prepared: 03/25/2014 Reviewed On: 03/25/2014

38.0.21

1 Identification

· Product Identifier· Product Name: Bacto Yeast Extract, Technical· Catalog Number: 288620· CAS Number:

8013-01-2· Relevant identified uses of the substance or mixture and uses advised against

No further relevant information available.· Application of the substance / the mixture In-vitro Diagnostics

· Details of the supplier of the safety data sheet· Manufacturer/Supplier:

BD Diagnostic Systems7 Loveton CircleSparks, MD 21152Telephone: (410) 771 - 0100 or (800) 638 – 8663Email Address: [email protected]

· Information Department: Technical Service· Emergency telephone number:

In case of a chemical emergency, spill, fire, exposure, or accident, contact BD DiagnosticSystems (410) 771-0100 or (800)-638-8663, or ChemTrec at (800) 424-9300.

2 Hazard(s) identification

· Classification of the substance or mixtureThe substance is not classified according to the Globally Harmonized System (GHS).

· Classification according to Directive 67/548/EEC or Directive 1999/45/ECThis product contains no hazardous constituents, or the concentration of all chemicalconstituents are below the regulatory threshold limits described by Occupational SafetyHealth Administration Hazard Communication Standard 29 CFR 1910.1200, the Canada'sWorkplace Hazardous Materials Information System (WHMIS) and the European Directive67/548/EEC and 1999/45/EC.

· Label elements· GHS label elements Void· Hazard pictograms Void· Signal word Void· Hazard statements Void· NFPA ratings (scale 0-4)

00

0

Health = 0Flammability = 0Reactivity = 0

· HMIS ratings (scale 0-4)

HEALTH

FIRE

REACTIVITY

0

0

0

Health = 0Flammability = 0Reactivity = 0

(Contd. on page 2) US

Page 2/7



Product Name: Bacto Yeast Extract, Technical

(Contd. of page 1)

38.0.21

· Other hazards· Results of PBT and vPvB assessment· PBT: Not applicable.· vPvB: Not applicable.

3 Composition/information on ingredients

· Chemical characterization: Substances· CAS No. Description:

8013-01-2 yeast extract

4 First-aid measures

· Description of first aid measures· General information No special measures required.· After inhalation Seek medical treatment in case of complaints.· After skin contact Immediately wash with water and soap and rinse thoroughly.· After eye contact

Rinse opened eye for several minutes under running water. If symptoms persist, consult adoctor.

· After swallowing If symptoms persist consult doctor.· Information for doctor Show this product label or this MSDS.· Most important symptoms and effects, both acute and delayed

No further relevant information available.· Indication of any immediate medical attention and special treatment needed

No further relevant information available.

5 Fire-fighting measures

· Extinguishing media· Suitable extinguishing agents

CO2, ABC multipurpose dry chemical or water spray. Fight larger fires with water spray oralcohol resistant foam.

· Special hazards arising from the substance or mixtureNo further relevant information available.

· Advice for firefighters· Protective equipment: No special measures required.

6 Accidental release measures

· Personal precautions, protective equipment and emergency procedures Not required.· Environmental precautions: Wipe up with damp sponge or mop.· Methods and material for containment and cleaning up: No special measures required.


Page 3/7




(Contd. of page 2)

38.0.21

· Reference to other sectionsSee Section 7 for information on safe handling.See Section 8 for information on personal protection equipment.See Section 13 for disposal information.

7 Handling and storage

· Handling· Precautions for safe handling Ensure good ventilation/exhaustion at the workplace.· Information about protection against explosions and fires:

No special measures required.

· Conditions for safe storage, including any incompatibilities· Storage· Requirements to be met by storerooms and receptacles: < 30 ℃· Information about storage in one common storage facility:

Store away from oxidizing agents.· Further information about storage conditions:

Store in cool, dry conditions in well sealed containers.· Specific end use(s) No further relevant information available.

8 Exposure controls/personal protection

· Additional information about design of technical systems:No further data; see Section 7.

· Control parameters· Components with limit values that require monitoring at the workplace: Not required.· Additional information: The lists that were valid during the creation were used as basis.

· Exposure controls· Personal Protective Equipment· General protective and hygienic measures

Wash hands before breaks and at the end of work.· Breathing equipment:

In case of brief exposure, use a chemical fume hood or a NIOSH/MSHA-approved respirator.· Protection of hands:

Chemical resistant gloves (i.e. nitrile, or equivalent).

· Eye protection: Safety glasses· Body protection: Protective work clothing (lab coat).

US

(Contd. on page 4)

Page 4/7




(Contd. of page 3)

38.0.21

9 Physical and chemical properties

· Information on basic physical and chemical properties· General Information· Appearance:

Form: Solid.Powder

Color: Beige· Odor: Characteristic

· Change in conditionMelting point/Melting range: Not determinedBoiling point/Boiling range: Not determined

· Flash point: Not applicable

· Flammability (solid, gaseous) Product is not flammable.

· Danger of explosion: Product does not present an explosion hazard.

· Density: Not determined

· Solubility in / Miscibility withWater: Insoluble

· Other information No further relevant information available.

10 Stability and reactivity

· Reactivity· Chemical stability· Thermal decomposition / conditions to be avoided:

No decomposition if used according to specifications.· Possibility of hazardous reactions No dangerous reactions known· Conditions to avoid No further relevant information available.· Incompatible materials: Incompatible material: strong oxidizers.· Hazardous decomposition products: No dangerous decomposition products known.

11 Toxicological information

· Information on toxicological effects· Acute toxicity:· Primary irritant effect:· on the skin: No irritating effect.· on the eye: No irritating effect.· Sensitization: No sensitizing effects known.


Page 5/7




(Contd. of page 4)

38.0.21

· Additional toxicological information:The product is not subject to OSHA classification according to internally approved calculationmethods for preparations.When used and handled according to specifications, the product does not have any harmfuleffects according to our experience and the information provided to us.The substance is not subject to classification.

· Carcinogenic categories· IARC (International Agency for Research on Cancer)

Substance is not listed.

· NTP (National Toxicology Program)Substance is not listed.

12 Ecological information

· Toxicity· Aquatic toxicity: No further relevant information available.· Persistence and degradability No further relevant information available.· Behavior in environmental systems:· Bioaccumulative potential No further relevant information available.· Mobility in soil No further relevant information available.· Ecotoxical effects:· Other information:

The ecological effects have not been thoroughly investigated, but currently none have beenidentified.

· Additional ecological information:· General notes: Generally not hazardous for water.· Results of PBT and vPvB assessment· PBT: Not applicable.· vPvB: Not applicable.· Other adverse effects No further relevant information available.

13 Disposal considerations

· Waste treatment methods· Recommendation

Smaller quantities can be disposed of with solid waste.Dispose of material in accordance with federal (40 CFR 261.3), state and local requirements.This product is not considered a RCRA hazardous waste.

· Uncleaned packagings:· Recommendation: Disposal must be made according to state and federal regulations.


Page 6/7




(Contd. of page 5)

38.0.21

· Recommended cleansing agent: Water, if necessary with cleansing agents.

14 Transport information

· UN-Number

· DOT, ADR, ADN, IMDG, IATA Void

· UN proper shipping name

· DOT, ADR, ADN, IMDG, IATA Void

· Transport hazard class(es)

· DOT, ADR, ADN, IMDG, IATA

· Class Void

· Packing group

· DOT, ADR, IMDG, IATA Void

· Environmental hazards:· Marine pollutant: No

· Special precautions for user Not applicable.

· Transport in bulk according to Annex II ofMARPOL73/78 and the IBC Code Not applicable.

· Transport/Additional information: If a "void" appears in the Hazard Class sectionfor the type of transportation, this indicates theproduct is not regulated for transportation.

· UN "Model Regulation": -

15 Regulatory information

· Safety, health and environmental regulations/legislation specific for the substance ormixture

· SARA Section 355 (extremely hazardous substances)Substance is not listed.

· SARA Section 313 (specific toxic chemical listings)Substance is not listed.

· TSCA (Toxic Substances Control Act)Substance is listed.

· California Proposition 65 - Chemicals known to cause cancerSubstance is not listed.


Page 7/7




(Contd. of page 6)

38.0.21

· California Proposition 65 - Chemicals known to cause reproductive toxicity forfemales:Substance is not listed.

· California Proposition 65 - Chemicals known to cause reproductive toxicity for males:Substance is not listed.

· California Proposition 65 - Chemicals known to cause developmental toxicity:Substance is not listed.

· Carcinogenic categories· TLV (Threshold Limit Value established by ACGIH)

Substance is not listed.· GHS label elements Void· Hazard pictograms Void· Signal word Void· Hazard statements Void

· National regulations

· Water hazard class: Generally not hazardous for water.· Chemical safety assessment: A Chemical Safety Assessment has not been carried out.

16 Other informationTo the best of our knowledge, the information contained herein is accurate. However, neitherBecton, Dickinson and Company or any of its subsidiaries assumes any liabilities whatsoeverfor the accuracy or completeness of the information contained herein. Final determination ofsuitability of any material is the sole responsibility of the user. All materials may presentunknown hazards and should be used with caution. Although certain hazards are describedherein, we can not guarantee that these are the only hazards that exist.

· Department issuing MSDS:Environmental, Health & SafetyCreated by Michael J. Spinazzola

· Contact: Technical Service Representative· Date of preparation / last revision 03/25/2014 / -· Abbreviations and acronyms:

RID: Règlement international concernant le transport des marchandises dangereuses par chemin de fer(Regulations Concerning the International Transport of Dangerous Goods by Rail)IATA-DGR: Dangerous Goods Regulations by the "International Air Transport Association" (IATA)ICAO: International Civil Aviation OrganizationICAO-TI: Technical Instructions by the "International Civil Aviation Organization" (ICAO)ADR: Accord européen sur le transport des marchandises dangereuses par Route (European Agreementconcerning the International Carriage of Dangerous Goods by Road)IMDG: International Maritime Code for Dangerous GoodsDOT: US Department of TransportationIATA: International Air Transport AssociationACGIH: American Conference of Governmental Industrial HygienistsCAS: Chemical Abstracts Service (division of the American Chemical Society)NFPA: National Fire Protection Association (USA)HMIS: Hazardous Materials Identification System (USA)

US


1111. . . . Product and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationMaterial nameMaterial nameMaterial nameMaterial name CITRIC ACID MONOHYDRATECITRIC ACID MONOHYDRATECITRIC ACID MONOHYDRATECITRIC ACID MONOHYDRATEVersion #Version #Version #Version # 02Revision dateRevision dateRevision dateRevision date 06-17-2011CAS #CAS #CAS #CAS # 5949-29-1Product CodesProduct CodesProduct CodesProduct Codes J.T.Baker: 0110, 0115, 0116, 0118, 0119, 0120J.T.Baker: 0110, 0115, 0116, 0118, 0119, 0120J.T.Baker: 0110, 0115, 0116, 0118, 0119, 0120J.T.Baker: 0110, 0115, 0116, 0118, 0119, 0120

Macron: 0616, 0627, 11213, 7788Macron: 0616, 0627, 11213, 7788Macron: 0616, 0627, 11213, 7788Macron: 0616, 0627, 11213, 7788Synonym(s)Synonym(s)Synonym(s)Synonym(s) 1,2,3-PROPANETRICARBOXYLIC ACID, 2-HYDROXY-, HYDRATE (1:1)



Avantor Performance Materials, Inc.222 Red School LanePhillipsburg, NJ 08865US

2222. . . . Hazards IdentificationHazards IdentificationHazards IdentificationHazards IdentificationEmergency overviewEmergency overviewEmergency overviewEmergency overview DANGER

Contact will irritate or burn eyes. Irritating to respiratory system and skin.OSHA regulatory statusOSHA regulatory statusOSHA regulatory statusOSHA regulatory status This product is considered hazardous under 29 CFR 1910.1200 (Hazard Communication).

Potential health effectsPotential health effectsPotential health effectsPotential health effectsRoutes of exposureRoutes of exposureRoutes of exposureRoutes of exposure Inhalation. Skin contact. Eye contact. Ingestion.EyesEyesEyesEyes Severely irritating, and may seriously damage eye tissue.SkinSkinSkinSkin Causes skin irritation.InhalationInhalationInhalationInhalation Inhalation of dusts may cause respiratory irritation.IngestionIngestionIngestionIngestion Expected to be a low ingestion hazard. May cause irritation of the gastrointestinal tract.

Target organsTarget organsTarget organsTarget organs Eyes. Skin. Upper respiratory tract.Chronic effectsChronic effectsChronic effectsChronic effects None known.Potential environmental effectsPotential environmental effectsPotential environmental effectsPotential environmental effects The product components are not classified as environmentally hazardous. However, this does not

exclude the possibility that large or frequent spills can have a harmful or damaging effect on theenvironment.

ComponentsComponentsComponentsComponents CAS #CAS #CAS #CAS # PercentPercentPercentPercent


5949-29-1 99 - 100CITRIC ACID MONOHYDRATE



Eye contactEye contactEye contactEye contact Immediately flush with plenty of water for at least 15 minutes. If easy to do, remove contactlenses. Get medical attention immediately.

Skin contactSkin contactSkin contactSkin contact Immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Getmedical attention if irritation develops or persists.

InhalationInhalationInhalationInhalation Move to fresh air. Treat symptomatically. Call a physician if symptoms develop or persist.IngestionIngestionIngestionIngestion Drink plenty of water. Seek medical advice. If ingestion of a large amount does occur, call a

poison control center immediately.Material name: CITRIC ACID MONOHYDRATEMSDS ID: C4730 Version #: 02 Revision date: 06-17-2011

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Notes to physicianNotes to physicianNotes to physicianNotes to physician Treat symptomatically.General adviceGeneral adviceGeneral adviceGeneral advice Ensure that medical personnel are aware of the material(s) involved, and take precautions to


5555. . . . Fire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFlammable propertiesFlammable propertiesFlammable propertiesFlammable properties Dust may form explosive mixture with air.


Water. Carbon dioxide (CO2). Dry chemical.


None known.

Protection of firefightersProtection of firefightersProtection of firefightersProtection of firefightersProtective equipment andProtective equipment andProtective equipment andProtective equipment andprecautions for firefightersprecautions for firefightersprecautions for firefightersprecautions for firefighters

Firefighters should wear full protective gear. Wear full protective clothing, including helmet,self-contained positive pressure or pressure demand breathing apparatus, protective clothing andface mask.



Specific methodsSpecific methodsSpecific methodsSpecific methods In the event of fire, cool tanks with water spray. In the event of fire and/or explosion do notbreathe fumes.

Hazardous combustion productsHazardous combustion productsHazardous combustion productsHazardous combustion products Carbon monoxide and carbon dioxide.

6666. . . . Accidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresPersonal precautionsPersonal precautionsPersonal precautionsPersonal precautions Keep unnecessary personnel away. Keep upwind. Ventilate the area. Avoid inhalation of dust

from the spilled material. Do not touch damaged containers or spilled material unless wearingappropriate protective clothing.

Environmental precautionsEnvironmental precautionsEnvironmental precautionsEnvironmental precautions Prevent further leakage or spillage if safe to do so.Methods for containmentMethods for containmentMethods for containmentMethods for containment ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). If

sweeping of a contaminated area is necessary use a dust suppressant agent which does notreact with the product. Prevent entry into waterways, sewer, basements or confined areas.

Methods for cleaning upMethods for cleaning upMethods for cleaning upMethods for cleaning up Avoid dust formation.

Small Spills: Sweep up or vacuum up spillage and collect in suitable container for disposal.

Large Spills: Collect dust or particulates using a vacuum cleaner with a HEPA filter. Reduceairborne dust and prevent scattering by moistening with water.

Never return spills in original containers for re-use. Clean contaminated surface thoroughly. Cleanup in accordance with all applicable regulations.

7777. . . . Handling and StorageHandling and StorageHandling and StorageHandling and StorageHandlingHandlingHandlingHandling Keep formation of airborne dusts to a minimum. Dust may form explosive mixture with air. Avoid

heat, sparks, open flames and other ignition sources. Avoid breathing dust. Do not get in eyesand avoid contact with skin and clothing. Use only with adequate ventilation. Wash thoroughlyafter handling. Keep container closed. Wear appropriate personal protective equipment. SeeSection 8 of the MSDS for Personal Protective Equipment.

StorageStorageStorageStorage Keep containers tightly closed in a dry, cool and well-ventilated place.

8888. . . . Exposure Controls Exposure Controls Exposure Controls Exposure Controls / / / / Personal ProtectionPersonal ProtectionPersonal ProtectionPersonal ProtectionExposure guidelinesExposure guidelinesExposure guidelinesExposure guidelines Not established.Engineering controlsEngineering controlsEngineering controlsEngineering controls Good general ventilation (typically 10 air changes per hour) should be used. Ventilation rates

should be matched to conditions. If applicable, use process enclosures, local exhaust ventilation,or other engineering controls to maintain airborne levels below recommended exposure limits. Ifexposure limits have not been established, maintain airborne levels to an acceptable level.

Personal protective equipmentPersonal protective equipmentPersonal protective equipmentPersonal protective equipmentEye / face protectionEye / face protectionEye / face protectionEye / face protection Wear safety glasses with side shields (or goggles) and a face shield.

Material name: CITRIC ACID MONOHYDRATEMSDS ID: C4730 Version #: 02 Revision date: 06-17-2011

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Skin protectionSkin protectionSkin protectionSkin protection Wear appropriate chemical resistant clothing. Wear appropriate chemical resistant gloves.Respiratory protectionRespiratory protectionRespiratory protectionRespiratory protection If engineering controls do not maintain airborne concentrations below recommended exposure

limits (where applicable) or to an acceptable level (in countries where exposure limits have notbeen established), an approved respirator must be worn. Respirator type: High-efficiencyparticulate respirator with full facepiece.

General hygeineGeneral hygeineGeneral hygeineGeneral hygeineconsiderationsconsiderationsconsiderationsconsiderations


9999. . . . Physical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesAppearanceAppearanceAppearanceAppearance Granular.

ColorColorColorColor White.




FormFormFormForm Powder.

pHpHpHpH 2.2 (0.1 N Solution)

Melting pointMelting pointMelting pointMelting point 275 - 305.6 °F (135 - 152 °C)

Freezing pointFreezing pointFreezing pointFreezing point 275 - 305.6 °F (135 - 152 °C)

Boiling pointBoiling pointBoiling pointBoiling point Decomposes




Not available.


Not available.




Solubility (water)Solubility (water)Solubility (water)Solubility (water) Soluble


Not available

Auto-ignition temperatureAuto-ignition temperatureAuto-ignition temperatureAuto-ignition temperature 1850 °F (1010 °C)


Molecular formulaMolecular formulaMolecular formulaMolecular formula C6-H10-O8

10101010. . . . Chemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical stabilityChemical stabilityChemical stabilityChemical stability Stable under normal temperature conditions.Conditions to avoidConditions to avoidConditions to avoidConditions to avoid Avoid dust formation. Excessive heat. Exposure to moisture.Incompatible materialsIncompatible materialsIncompatible materialsIncompatible materials Strong oxidizing agents.Hazardous decompositionHazardous decompositionHazardous decompositionHazardous decompositionproductsproductsproductsproducts

Carbon Dioxide. Carbon monoxide.



Toxicological dataToxicological dataToxicological dataToxicological data

11111111. . . . Toxicological InformationToxicological InformationToxicological InformationToxicological Information

ProductProductProductProduct Test ResultsTest ResultsTest ResultsTest ResultsAcute Oral LD50 Rat: 6730 mg/kgCITRIC ACID MONOHYDRATE (5949-29-1)


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SensitizationSensitizationSensitizationSensitization Not a skin sensitizer.

Local effectsLocal effectsLocal effectsLocal effects Severe eye irritation. May cause burns. Irritating to respiratory system and skin.

Chronic effectsChronic effectsChronic effectsChronic effects None known.


Skin corrosion/irritationSkin corrosion/irritationSkin corrosion/irritationSkin corrosion/irritation Causes skin irritation.



Neurological effectsNeurological effectsNeurological effectsNeurological effects None known.




Irritant effects.




LC50 Green or Europeon shore crab (Carcinus maenas): 160mg/l 48.00 hours

CITRIC ACID MONOHYDRATE (5949-29-1)

EcotoxicityEcotoxicityEcotoxicityEcotoxicity This product has no known eco-toxicological effects.

Environmental effectsEnvironmental effectsEnvironmental effectsEnvironmental effects Ecological injuries are not known or expected under normal use. An environmental hazard cannotbe excluded in the event of unprofessional handling or disposal.


This material is readily biodegraded and is not likely to bioconcentrate.


Not available

13131313. . . . Disposal ConsiderationsDisposal ConsiderationsDisposal ConsiderationsDisposal ConsiderationsDisposal instructionsDisposal instructionsDisposal instructionsDisposal instructions Dispose of contents/container in accordance with local/regional/national/international regulations.Contaminated packagingContaminated packagingContaminated packagingContaminated packaging Offer rinsed packaging material to local recycling facilities. Since emptied containers retain

product residue, follow label warnings even after container is emptied.




15151515. . . . Regulatory InformationRegulatory InformationRegulatory InformationRegulatory InformationUS federal regulationsUS federal regulationsUS federal regulationsUS federal regulations This product is a "Hazardous Chemical" as defined by the OSHA Hazard Communication

Standard, 29 CFR 1910.1200.CERCLA/SARA Hazardous Substances - Not applicable.


CERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityNone


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Superfund Amendments and Reauthorization Act of 1986 (SARA)Superfund Amendments and Reauthorization Act of 1986 (SARA)Superfund Amendments and Reauthorization Act of 1986 (SARA)Superfund Amendments and Reauthorization Act of 1986 (SARA)Hazard categoriesHazard categoriesHazard categoriesHazard categories Immediate Hazard - Yes



Yes

Food and Drug AdministrationFood and Drug AdministrationFood and Drug AdministrationFood and Drug Administration(FDA)(FDA)(FDA)(FDA)

Total food additiveDirect food additiveGRAS food additive


YesAustralia Australian Inventory of Chemical Substances (AICS)YesCanada Domestic Substances List (DSL)NoCanada Non-Domestic Substances List (NDSL)

YesChina Inventory of Existing Chemical Substances in China (IECSC)YesEurope European Inventory of Existing Commercial Chemical


YesJapan Inventory of Existing and New Chemical Substances (ENCS)YesKorea Existing Chemicals List (ECL)YesNew Zealand New Zealand InventoryYesPhilippines Philippine Inventory of Chemicals and Chemical Substances




Saf-T-DataSaf-T-DataSaf-T-DataSaf-T-Data Health: 1 - SlightFlammability: 2 - ModerateReactivity: 1 - SlightContact: 3 - SevereLab Protective Equip: D - GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPERGLOVESStorage Color Code: G - Green (General Storage)

16161616. . . . Labeling InfoLabeling InfoLabeling InfoLabeling InfoLabel Hazard WarningLabel Hazard WarningLabel Hazard WarningLabel Hazard Warning DANGER

Contact will irritate or burn eyes. Irritating to respiratory system and skin.Label PrecautionsLabel PrecautionsLabel PrecautionsLabel Precautions Keep away from heat, sparks and flame. Avoid breathing dust. Do not get in eyes and avoid

contact with skin and clothing. Use only with adequate ventilation. Wash thoroughly afterhandling. Keep container closed.

Label First AidLabel First AidLabel First AidLabel First Aid Immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention. Flushskin thoroughly with water. If gas/fume/vapor/dust/mist from the material is inhaled, remove theaffected person immediately to fresh air. Get medical attention if irritation develops or persists. Ifingestion of a large amount does occur, call a poison control center immediately.




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Issue dateIssue dateIssue dateIssue date 06-17-2011This data sheet containsThis data sheet containsThis data sheet containsThis data sheet containschanges from the previouschanges from the previouschanges from the previouschanges from the previousversion in section(s):version in section(s):version in section(s):version in section(s):

This document has undergone significant changes and should be reviewed in its entirety.


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SAFETY DATA SHEET




Page 1 of 14




Product name Ethylenediaminetetraacetic acid dipotassium salt dihydrate for

synthesis






CAS-No. 25102-12-9


Identified uses Chemical for synthesis






India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6


number


SAFETY DATA SHEET



Product name Ethylenediaminetetraacetic acid dipotassium salt dihydrate for synthesis


Page 2 of 14



Classification (REGULATION (EC) No 1272/2008)

Acute toxicity, Category 4, Inhalation, H332

Specific target organ toxicity - repeated exposure, Category 2, Inhalation, Respiratory Tract, H373


2.2 Label elements


Hazard pictograms

Signal word

Warning

Hazard statements

H332 Harmful if inhaled.

H373 May cause damage to organs (Respiratory Tract) through prolonged or repeated exposure if

inhaled.


Response

P314 Get medical advice/ attention if you feel unwell.


Hazard pictograms

SAFETY DATA SHEET





Page 3 of 14

Signal word

Warning

Contains: ethylenediaminetetraacetic acid dipotassium salt dihydrate

CAS-No. 25102-12-9

2.3 Other hazards

None known.


3.1 Substance

Formula C₁₀H₁₄K₂N₂O₈ * 2H₂O (Hill)

EC-No. 217-895-0


Hazardous components (REGULATION (EC) No 1272/2008)

Chemical name (Concentration)

CAS-No. Registration number Classification

ethylenediaminetetraacetic acid dipotassium salt dihydrate (<= 100 % )

25102-12-9 *)

Acute toxicity, Category 4, H332

Specific target organ toxicity - repeated exposure, Category 2,

H373

*) A registration number is not available for this substance as the substance or its use are exempted from registration according to Article

2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later

registration deadline.


3.2 Mixture

Not applicable

SAFETY DATA SHEET





Page 4 of 14



After inhalation: fresh air. Call in physician. If breathing stops: immediately apply artificial

respiration, if necessary also oxygen.


shower. Consult a physician.

After eye contact: rinse out with plenty of water. Remove contact lenses. Call in ophthalmologist.

After swallowing: immediately make victim drink water (two glasses at most). Consult a

physician.


irritant effects










Combustible.



nitrogen oxides


SAFETY DATA SHEET





Page 5 of 14



Further information





Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure

adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an

expert.















Work under hood. Do not inhale substance/mixture.

SAFETY DATA SHEET





Page 6 of 14

Hygiene measures

Change contaminated clothing. Preventive skin protection recommended. Wash hands after

working with substance.


Storage conditions












See section 7.1.





Eye/face protection

Safety glasses

Hand protection

full contact:


SAFETY DATA SHEET





Page 7 of 14



splash contact:













Other protective equipment

protective clothing



Recommended Filter type: Filter P 2 (acc. to DIN 3181) for solid and liquid particles of harmful

substances








Form solid

SAFETY DATA SHEET





Page 8 of 14

Colour white

Odour odourless


pH 4 - 5

at 50 g/l

20 °C

Melting point 272 °C







Vapour pressure at 20 °C

low




Water solubility at 20 °C

soluble

SAFETY DATA SHEET





Page 9 of 14


octanol/water







9.2 Other data



10.1 Reactivity



assumed.


releases water of crystallisation when heated.



Caution! In contact with nitrites, nitrates, nitrous acid possible liberation of nitrosamines!





SAFETY DATA SHEET





Page 10 of 14





Acute oral toxicity

LD50 Rat: > 2,000 mg/kg

(External MSDS)


Acute toxicity estimate: 1.6 mg/l; dust/mist

Expert judgement

The value is given in analogy to the following substances: Ethylenedinitrilotetraacetic acid

disodium salt



Skin irritation

slight irritation

Eye irritation

slight irritation

Sensitisation




Carcinogenicity




Teratogenicity


SAFETY DATA SHEET





Page 11 of 14




May cause damage to organs through prolonged or repeated exposure.

Exposure routes: Inhalation

Target Organs: Respiratory Tract

The value is given in analogy to the following substances: Ethylenedinitrilotetraacetic acid

disodium salt

Aspiration hazard




Damage to:

Kidney

Under given conditions, contact with nitrites or nitric acid can lead to the formation of

nitrosamines, which have shown themselves to be carcinogenic in animal experiments.

Other dangerous properties can not be excluded.



12.1 Toxicity



Biodegradability








SAFETY DATA SHEET





Page 12 of 14







the product itself.






regulations.


Not relevant



regulations.



regulations.


Not relevant



SAFETY DATA SHEET





Page 13 of 14








H373 May cause damage to organs through prolonged or repeated

exposure if inhaled.

Training advice


Labelling

Hazard pictograms

Signal word

Warning

Hazard statements


H373 May cause damage to organs (Respiratory Tract) through prolonged or repeated exposure if

inhaled.


Response

P314 Get medical advice/ attention if you feel unwell.

SAFETY DATA SHEET





Page 14 of 14

Contains: ethylenediaminetetraacetic acid dipotassium salt dihydrate





SAFETY DATA SHEET




Page 1 of 17




Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph

Eur






CAS-No. 7791-13-1








India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6

SAFETY DATA SHEET



Product name Cobalt(II) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur


Page 2 of 17


number





Acute toxicity, Category 4, Oral, H302

Respiratory sensitisation, Category 1, H334

Skin sensitisation, Category 1, H317

Germ cell mutagenicity, Category 2, H341

Carcinogenicity, Category 1B, Inhalation, H350i

Reproductive toxicity, Category 1B, H360F

Acute aquatic toxicity, Category 1, H400

Chronic aquatic toxicity, Category 1, H410


2.2 Label elements


Hazard pictograms

Signal word

Danger

Hazard statements

H350i May cause cancer by inhalation.

H360F May damage fertility.

H302 Harmful if swallowed.

SAFETY DATA SHEET





Page 3 of 17

H317 May cause an allergic skin reaction.

H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.

H341 Suspected of causing genetic defects.

H410 Very toxic to aquatic life with long lasting effects.


Prevention

P201 Obtain special instructions before use.

P273 Avoid release to the environment.

P280 Wear protective gloves.

Response

P302 + P352 IF ON SKIN: Wash with plenty of soap and water.

P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for

breathing.

P342 + P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor.



Hazard pictograms

Signal word

Danger

Hazard statements










P304 + P341 IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable

SAFETY DATA SHEET





Page 4 of 17

for breathing.

P308 + P313 IF exposed or concerned: Get medical advice/ attention.

CAS-No. 7791-13-1

2.3 Other hazards

None known.


3.1 Substance

Formula Cl₂Co * 6 H₂O Cl₂Co * 6 H₂O (Hill)

EC-No. 231-589-4





Cobalt(II) chloride hexahydrate (>= 20 % - < 25 % )

7791-13-1 *)


Respiratory sensitisation, Category 1, H334


Germ cell mutagenicity, Category 2, H341

Carcinogenicity, Category 1B, H350i

Reproductive toxicity, Category 1B, H360F



M-Factor: 10





SAFETY DATA SHEET





Page 5 of 17

3.2 Mixture

Not applicable



General advice

First aider needs to protect himself.




After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.


physician.


Allergic reactions, irritant effects, Diarrhoea, Tremors

Symptoms of an acute cobalt intoxication: diarrhoea, loss of appetite, drop in body temperature,

drop in blood pressure. Toxic effect on kidneys (proteinuria, anuria), heart, and pancreas.







environment.



SAFETY DATA SHEET





Page 6 of 17


Not combustible.



Hydrogen chloride gas



Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by

keeping a safe distance or by wearing suitable protective clothing.

Further information





Advice for non-emergency personnel: Avoid generation and inhalation of dusts in all

circumstances. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger

area, observe emergency procedures, consult an expert.







sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area. Avoid

generation of dusts.


SAFETY DATA SHEET





Page 7 of 17






Work under hood. Do not inhale substance/mixture.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and

face after working with substance.


Storage conditions

Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only

to qualified or authorised persons.











See section 7.1.

SAFETY DATA SHEET





Page 8 of 17





Eye/face protection

Safety glasses

Hand protection

full contact:




splash contact:














protective clothing



Recommended Filter type: Filter P 3 (acc. to DIN 3181) for solid and liquid particles of toxic

and very toxic substances

SAFETY DATA SHEET





Page 9 of 17








Form solid

Colour violet

Odour odourless


pH ca. 4.9

at 50 g/l

25 °C





Flammability (solid, gas) The product is not flammable.


SAFETY DATA SHEET





Page 10 of 17




Density 1.92 g/cm3

at 25 °C



at 0 °C

191 g/l

at 100 °C


octanol/water







9.2 Other data


SAFETY DATA SHEET





Page 11 of 17


10.1 Reactivity

See section 10.3






Alkali metals









Acute oral toxicity

LD50 Rat: 766 mg/kg

(RTECS)

Symptoms: Tremors, Diarrhoea


Symptoms: Irritation symptoms in the respiratory tract.

SAFETY DATA SHEET





Page 12 of 17


LD50 Rat: > 2,000 mg/kg

(RTECS) Tricobalt tetraoxide

Skin irritation

Possible damages: slight irritation

Eye irritation


Sensitisation

May cause allergy or asthma symptoms or breathing difficulties if inhaled.

May cause an allergic skin reaction.



Carcinogenicity




Teratogenicity


CMR effects

Carcinogenicity:

May cause cancer by inhalation.

Mutagenicity:

Suspected of causing genetic defects.

Reproductive toxicity:

May damage fertility.



SAFETY DATA SHEET





Page 13 of 17



Aspiration hazard



Symptoms of an acute cobalt intoxication: diarrhoea, loss of appetite, drop in body temperature,

drop in blood pressure. Toxic effect on kidneys (proteinuria, anuria), heart, and pancreas.


This substance should be handled with particular care.


12.1 Toxicity













SAFETY DATA SHEET





Page 14 of 17





the product itself.






14.2 Proper shipping name ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID,

N.O.S. (COBALT DICHLORIDE)

14.3 Class 9



14.6 Special precautions for

user

yes

Tunnel restriction code -

Packages smaller than or equal to 5 kg / L , not dangerous goods of Class 9


Not relevant


SAFETY DATA SHEET





Page 15 of 17




14.3 Class 9




user

no






14.3 Class 9




user

yes

EmS F-A S-F



Not relevant




Storage class 6.1 D


SAFETY DATA SHEET





Page 16 of 17






H334 May cause allergy or asthma symptoms or breathing difficulties if

inhaled.




H400 Very toxic to aquatic life.


Training advice


Labelling

Hazard pictograms

Signal word

Danger

Hazard statements






SAFETY DATA SHEET





Page 17 of 17




Prevention




Response



breathing.

P342 + P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor.

Further information






Manganese chloride tetrahydrate

Manganese dichloride tetrahydrate; Manganous chloridetetrahydrate

Manganese (II) Chloride, tetrahydrate

MnCl2.4H2O

Not available.

OO9625000

13446-34-9

M1105, M1106, M1109

Not available.

SPECTRUM LABORATORY PRODUCTS INC.14422 S. SAN PEDRO STREETGARDENA, CA 90248

CALL (310) 516-8000

SPECTRUM LABORATORY PRODUCTS INC.14422 S. SAN PEDRO STREETGARDENA, CA 90248

01 0

Material Safety Data SheetNFPA HMIS Personal Protective Equipment

Section 1. Chemical Product and Company Identification

Common Name/Trade Name

CatalogNumber(s).

CAS#

RTECS

CI#

Manufacturer

Synonym

Chemical Name

Chemical Family

IN CASE OF EMERGENCYCHEMTREC (24hr) 800-424-9300

Chemical Formula

Supplier

See Section 15.

Commercial Name(s) Not available.

TSCA TSCA 8(b) inventory: Nop r o d u c t s w e r e f o u n d .Exempt from listing on TSCA8(b) inventory since it is ahydrate

1

0

0

Health Hazard

Fire Hazard

Reactivity

Page Number: 1

Manganese chloride tetrahydrate: ORAL (LD50): Acute: 1484 mg/kg [Rat].

1) Manganese chloride tetrahydrate 13446-34-9 1 3 100

Toxicological Dataon Ingredients

Name

Section 2.Composition and Information on Ingredients

Exposure Limits

TWA (mg/m3) STEL (mg/m3) CEIL (mg/m3) % by WeightCAS #

Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.

CARCINOGENIC EFFECTS: Not available.MUTAGENIC EFFECTS: Not available.TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available.The substance may be toxic to lungs, central nervous system (CNS).Repeated or prolonged exposure to the substance can produce target organs damage.

Section 3. Hazards Identification

Potential Acute Health Effects

Potential Chronic HealthEffects

Continued on Next Page

Manganese chloride tetrahydrate Page Number: 2

Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to anunconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosentight clothing such as a collar, tie, belt or waistband.

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water forat least 15 minutes. Cold water may be used. Get medical attention if irritation occurs.

Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritationdevelops. Cold water may be used.

Not available.

If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.Get medical attention.

Not available.

Not available.

Section 4. First Aid Measures

Eye Contact

Skin Contact

Serious Skin Contact

Inhalation

Serious Inhalation

Ingestion

Serious Ingestion

Not applicable.

Non-flammable.

Not available.

Not applicable.

Not applicable.

Not applicable.

Not applicable.

When heated to decomposition it emits toxic fumes of hydrogen chloride.

Risks of explosion of the product in presence of mechanical impact: Not available.Risks of explosion of the product in presence of static discharge: Not available.

Not available.

Section 5. Fire and Explosion Data

Flammability of the Product

Auto-Ignition Temperature

Flash Points

Flammable Limits

Products of Combustion

Fire Hazards in Presence ofVarious Substances

Explosion Hazards in Presenceof Various Substances

Fire Fighting Mediaand Instructions

Special Remarks onFire Hazards

Special Remarks on ExplosionHazards

Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning byspreading water on the contaminated surface and dispose of according to local and regional authorityrequirements.

Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreadingwater on the contaminated surface and allow to evacuate through the sanitary system. Be careful that theproduct is not present at a concentration level above TLV. Check TLV on the MSDS and with localauthorities.

Section 6. Accidental Release Measures

Small Spill

Large Spill



Keep container tightly closed. Keep container in a cool, well-ventilated area.

Do not ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical adviceimmediately and show the container or the label. Keep away from incompatibles such as metals.

Section 7. Handling and Storage

Precautions

Storage

Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels belowrecommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keepexposure to airborne contaminants below the exposure limit.

Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.Gloves.

Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should beused to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult aspecialist BEFORE handling this product.

TWA: 5 (mg(Mn)/m3) [Australia] Inhalation Total.TWA: 5 (mg(Mn)/m3) from OSHA (PEL) [United States] Inhalation Total.TWA: 0.2 (mg(Mn)/m3) from ACGIH (TLV) [United States] Inhalation Respirable.TWA: 5 (mg(Mn)/m3) [United Kingdom (UK)] Inhalation Total.TWA: 2.5 (mg(Mn)/m3) [Sweden] Inhalation Total.TWA: 1(mg(Mn)/m3) [Sweden] Inhalation Respirable.

Consult local authorities for acceptable exposure limits.

Section 8. Exposure Controls/Personal Protection

Engineering Controls

Personal Protection

Personal Protection in Case ofa Large Spill

Exposure Limits

1190°C (2174°F)

Solid.

Not available.

Not available.

58°C (136.4°F)

2.01 (Water = 1)

Not available.

Not applicable.

Not available.

Not available.

See solubility in water.

Easily soluble in cold water.

Not available.

Not available.

197.9 g/mole

Not available.

Not available.

Not available.

Section 9. Physical and Chemical Properties

Physical state and appearance Odor

Taste

Color

Molecular Weight

pH (1% soln/water)

Boiling Point

Melting Point

Critical Temperature

Specific Gravity

Vapor Pressure

Vapor Density

Volatility

Odor Threshold

Water/Oil Dist. Coeff.

Ionicity (in Water)

Dispersion Properties

Solubility

The product is stable.

Non-corrosive in presence of glass.

Reactive with metals.

Not available.

Excess heat, incompatible materials

Section 10. Stability and Reactivity Data

Stability

Instability Temperature

Conditions of Instability

Incompatibility with varioussubstances

Corrosivity



Not available.

Hygroscopic; keep container tightly closed.Incompatible with Zinc, potassium, sodium.

Special Remarks onReactivity

Special Remarks onCorrosivity

Polymerization Will not occur.

Inhalation. Ingestion.

Acute oral toxicity (LD50): 1484 mg/kg [Rat].

Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.

May cause damage to the following organs: lungs, central nervous system (CNS).

Not available.

Acute Potential Health Effects:Skin: May cause skin irritation.Eyes: May cause eye irritation.Inhalation: Low hazard. Acute poisoning is rare from acute inhalation. It may cause respiratory tractirritation, and mild to moderate inflammation of the respiratory tract and lung inflammation ("manganesepneumonitis"), bronchitis, exercise-induced dyspnea.Ingestion: May be harmful if swallowed. Acute poisoning is rare, but may occur. It may cause abdominalpain, nausea. It may also affect behavior/central nervous system/nervous system (nervousness, irritability,emotional lability, compulsive behavior, apathy, generalized muscle weakness, a low monotonous voice,muscle twitching, limb stiffness, speech impairment, insomnia, incoordinatioin, difficulty with fine movements,back pain, headache, clumsiness, personality changes, inappropriate crying, laughing and restlessness; gaitalteration, loss of balance, fine tremor, loss of facial expressions, and speech disturbances develops prior tothe onset of "parkinsonism", with muscle regidity, staggering gait, dysphagia, and a course intention tremorapperaring. May also cause sweating, salivation, diminished libido or impotence.Chronic Potential Health Effects:Ingestion or inhalation: It can affect behavior/central nervous system with symptoms similar to that of acuteingestion or inhalation. The primary clinical pattern following chronic exposure involves Parkinson-likesymptoms due to central nervous system effects. The neurologic disorder that develops is known as"manganism." Apsychiatric syndrom, once referred to as "manganese madness", may develop withsymptoms of compulsive behavior, emotional lability and hallucinations. Chronic exposure may also result insignificant decrease in heart rate, excessive salivation, increased sweating, pancreatitis, hypoglycemia,abdominal pain, hypermylasemia, and may affect metabolism (weight loss, hypercalcemia or hypocalcemia,liver, blood, kidneys, brain.

May cause adverse reproductive effects and birth defects (teratogenic) based on animal test data. May cause cancer based on animal test data May affect genetic material (mutagenic)

Section 11. Toxicological Information

Routes of Entry

Toxicity to Animals

Chronic Effects on Humans

Other Toxic Effects onHumans

Special Remarks onToxicity to Animals

Special Remarks onChronic Effects on Humans

Special Remarks on otherToxic Effects on Humans

Not available.

Not available.

Possibly hazardous short term degradation products are not likely. However, long term degradation productsmay arise.

The products of degradation are less toxic than the product itself.

Not available.

Section 12. Ecological Information

Ecotoxicity

BOD5 and COD

Products of Biodegradation

Toxicity of the Productsof Biodegradation

Special Remarks on theProducts of Biodegradation



Section 13. Disposal Considerations

Waste Disposal Waste must be disposed of in accordance with federal, state and local environmentalcontrol regulations.

DOT Classification Not a DOT controlled material (United States).

Not applicable.

Not applicable.

Section 14. Transport Information

Identification

DOT (Pictograms)

Special Provisions forTransport

EINECS: This product is not listed on the European Inventory of Existing Commercial Chemical Substances.Canada: Not listed on Canadian Domestic Substance List (DSL).China: Listed on National Inventory.Japan: Listed on National Inventory (ENCS).Korea: Not listed on National Inventory (KECI).Philippines: Listed on National Inventory (PICCS).Australia: Listed on AICS.

00

1

1

0

0

E

Not controlled under WHMIS (Canada).

R22- Harmful if swallowed.

Section 15. Other Regulatory Information and Pictograms

Other Regulations

Other Classifications WHMIS (Canada)

DSCL (EEC)

HMIS (U.S.A.) Health Hazard

Fire Hazard

Reactivity

National Fire ProtectionAssociation (U.S.A.)

Personal Protection

Health

Flammability

Reactivity

Specific hazard

WHMIS (Canada)(Pictograms)

DSCL (Europe)(Pictograms)

Federal and StateRegulations

SARA 313 toxic chemical notification and release reporting: Manganese chloride tetrahydrate (listed asManganese compounds).FDA: Everything Added To Food in the United Stated (EAFUS) list

CaliforniaProposition 65Warnings

California prop. 65: This product contains the following ingredients for which the State of California hasfound to cause cancer which would require a warning under the statute: No products were found.

California prop. 65: This product contains the following ingredients for which the State of California hasfound to cause birth defects which would require a warning under the statute: No products were found.

S46- If swallowed, seek medical adviceimmediately and show this container or label.



TDG (Canada)(Pictograms)

ADR (Europe)(Pictograms)

Protective Equipment

Dust respirator. Be sure to use anapproved/certified respirator orequivalent.

Lab coat.

Safety glasses.

Gloves.

Not available.

Not available.

CALL (310) 516-8000

All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product iscombined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop propermethods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products,Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.

Notice to Reader

Verified by Sonia Owen.

Printed 2/1/2012.

Validated by Sonia Owen on 2/1/2012.

Other SpecialConsiderations

References

Section 16. Other Information

MSDS Code M3350

SAFETY DATA SHEET




Page 1 of 17




Product name Copper(II) sulfate pentahydrate for analysis EMSURE®

ACS,ISO,Reag. Ph Eur






CAS-No. 7758-99-8


Identified uses

Reagent for analysis






India * Tel: 0091 22 6210 9000



SAFETY DATA SHEET



Product name Copper(II) sulfate pentahydrate for analysis EMSURE® ACS,ISO,Reag. Ph

Eur


Page 2 of 17

Tel : +91-2267863131-6


number






Serious eye damage, Category 1, H318




2.2 Label elements


Hazard pictograms

Signal word

Danger

Hazard statements


H318 Causes serious eye damage.



SAFETY DATA SHEET




Eur


Page 3 of 17

Prevention


P280 Wear eye protection.

Response

P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact

lenses, if present and easy to do. Continue rinsing.

P313 Get medical advice/ attention.


Hazard pictograms

Signal word

Danger

Hazard statements




P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present

and easy to do. Continue rinsing.


Contains: Copper(II) sulphate pentahydrate

CAS-No. 7758-99-8

2.3 Other hazards

None known.


3.1 Substance

SAFETY DATA SHEET




Eur


Page 4 of 17

Formula CuSO₄ * 5 H₂O CuO₄S * 5 H₂O (Hill)

EC-No. 231-847-6





Copper(II) sulphate pentahydrate (>= 80 % - <= 100 % )

7758-99-8 *)





M-Factor: 10





3.2 Mixture

Not applicable





shower.



physician.

SAFETY DATA SHEET




Eur


Page 5 of 17


irritant effects, conjunctivitis, gastric pain, Diarrhoea, Vomiting, collapse, death

Risk of corneal clouding.







environment.




Not combustible.



Sulphur oxides





Further information



SAFETY DATA SHEET




Eur


Page 6 of 17





expert.








of dusts.







Hygiene measures




Storage conditions

SAFETY DATA SHEET




Eur


Page 7 of 17












See section 7.1.





Eye/face protection

Safety glasses

Hand protection

full contact:




splash contact:


SAFETY DATA SHEET




Eur


Page 8 of 17













protective clothing




substances








Form solid

Colour blue

SAFETY DATA SHEET




Eur


Page 9 of 17

Odour odourless


pH 3.5 - 4.5

at 50 g/l

20 °C










Density 2.284 g/cm3

at 20 °C



at 20 °C

SAFETY DATA SHEET




Eur


Page 10 of 17


octanol/water







9.2 Other data

Ignition temperature Not applicable


10.1 Reactivity

See section 10.3





Strong oxidizing agents, hydroxylamine, magnesium





SAFETY DATA SHEET




Eur


Page 11 of 17





Acute oral toxicity

LD50 Rat: 482 mg/kg


Symptoms: gastric pain, Vomiting, Diarrhoea


Symptoms: Possible damages:, mucosal irritations


LD50 Rat: > 2,000 mg/kg


Skin irritation

Rabbit



Eye irritation

Rabbit

Result: Causes serious eye damage.


Causes serious eye damage.

SAFETY DATA SHEET




Eur


Page 12 of 17

Sensitisation

Maximisation Test Guinea pig

Result: negative



Genotoxicity in vivo

Micronucleus test

Mouse

male and female

Oral

Bone marrow

Result: negative

(ECHA)

unscheduled DNA synthesis assay

Rat

male

Oral

Liver cells

Result: negative


Genotoxicity in vitro

Ames test

Salmonella typhimurium

Result: negative


Carcinogenicity




SAFETY DATA SHEET




Eur


Page 13 of 17

Teratogenicity






Aspiration hazard



After absorption:

drop in blood pressure, tachycardia, collapse, acidosis

After a latency period:

death

Metal-fume fever after inhalation of large quantities.




12.1 Toxicity



Biodegradability

Not applicable for inorganic substances







SAFETY DATA SHEET




Eur


Page 14 of 17



Fungicide






the product itself.







N.O.S. (COPPER(II)-SULPHATE)

14.3 Class 9




user

yes




Not relevant

SAFETY DATA SHEET




Eur


Page 15 of 17





14.3 Class 9




user

no






14.3 Class 9




user

yes

EmS F-A S-F

Segregation Group 0007 Heavy Metals and their salts (incl. their organometallic

compounds)



Not relevant



SAFETY DATA SHEET




Eur


Page 16 of 17











Training advice


Labelling

Hazard pictograms

Signal word

Danger

Hazard statements





SAFETY DATA SHEET




Eur


Page 17 of 17

Prevention



Response




Contains: Copper(II) sulphate pentahydrate





p. 1

0 1 0

He a lt h

Fire

Re a c t iv it y

Pe rs o n a lPro t e c t io n

2

0

0

E

Material Safety Data SheetBoric acid MSDS

Section 1: Chemical Product and Company Identification

Product Name: Boric acid

Catalog Codes: SLB2533, SLB4513

CAS#: 10043-35-3

RTECS: ED4550000

TSCA: TSCA 8(b) inventory: Boric acid

CI#: Not available.

Synonym:

Chemical Name: Boric Acid

Chemical Formula: H3BO3

Contact Information:

Sciencelab.com, Inc.14025 Smith Rd.Houston, Texas 77396

US Sales: 1-800-901-7247International Sales: 1-281-441-4400

Order Online: ScienceLab.com

CHEMTREC (24HR Emergency Telephone), call:1-800-424-9300

International CHEMTREC, call: 1-703-527-3887

For non-emergency assistance, call: 1-281-441-4400

Section 2: Composition and Information on Ingredients

Composition:

Name CAS # % by Weight

Boric acid 10043-35-3 100

Toxicological Data on Ingredients: Boric acid: ORAL (LD50): Acute: 2660 mg/kg [Rat]. 3450 mg/kg [Mouse].

Section 3: Hazards Identification

Potential Acute Health Effects:Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Slightly hazardous in case ofskin contact (permeator).

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast. TERATOGENICEFFECTS: Not available. DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male [POSSIBLE]. The substance may be toxic to kidneys, cardiovascular system, central nervous system (CNS).Repeated or prolonged exposure to the substance can produce target organs damage.

Section 4: First Aid Measures

Eye Contact:

http://www.sciencelab.com/

p. 2

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Cold water may be used. Get medical attention.

Skin Contact:In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminatedclothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medicalattention.

Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical attention.

Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention.

Serious Inhalation: Not available.

Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear.

Serious Ingestion: Not available.

Section 5: Fire and Explosion Data

Flammability of the Product: Non-flammable.

Auto-Ignition Temperature: Not applicable.

Flash Points: Not applicable.

Flammable Limits: Not applicable.

Products of Combustion: Not available.

Fire Hazards in Presence of Various Substances: Not applicable.

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Risks of explosion of the product inpresence of static discharge: Not available.

Fire Fighting Media and Instructions: Not applicable.

Special Remarks on Fire Hazards: Not available.

Special Remarks on Explosion Hazards:A mixture of potassium and boric acid may explode on impact. A mixture of boric acid and acetic anydride will explode whenheated to 58-60 C

Section 6: Accidental Release Measures

Small Spill:Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water onthe contaminated surface and dispose of according to local and regional authority requirements.

Large Spill:Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on thecontaminated surface and allow to evacuate through the sanitary system.

Section 7: Handling and Storage

Precautions:

p. 3

Keep locked up.. Do not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation,wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoidcontact with skin and eyes. Keep away from incompatibles such as alkalis.

Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 23°C (73.4°F).

Section 8: Exposure Controls/Personal Protection

Engineering Controls:Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommendedexposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminantsbelow the exposure limit.

Personal Protection:Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.

Personal Protection in Case of a Large Spill:Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoidinhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling thisproduct.

Exposure Limits: Not available.

Section 9: Physical and Chemical Properties

Physical state and appearance: Solid. (Powdered solid.)

Odor: Odorless.

Taste: Bitter. (Slight.)

Molecular Weight: 61.83 g/mole

Color: White.

pH (1% soln/water): 5.2 [Acidic.]

Boiling Point: 300°C (572°F)

Melting Point: 169°C (336.2°F)

Critical Temperature: Not available.

Specific Gravity: 1.435 (Water = 1)

Vapor Pressure: Not applicable.

Vapor Density: Not available.

Volatility: Not available.

Odor Threshold: Not available.

Water/Oil Dist. Coeff.: Not available.

Ionicity (in Water): Not available.

Dispersion Properties: See solubility in water, methanol.

Solubility:Soluble in hot water, methanol. Partially soluble in cold water. Very slightly soluble in acetone.

Section 10: Stability and Reactivity Data

p. 4

Stability: The product is stable.

Instability Temperature: Not available.

Conditions of Instability: High temperatures, dust generation, incompatible materials.

Incompatibility with various substances: Reactive with alkalis.

Corrosivity: Not available.

Special Remarks on Reactivity: Incompatible with Potassium , Acetic Anhydride. Reacts with basic materials to form boratesalts.

Special Remarks on Corrosivity: Not available.

Polymerization: Will not occur.

Section 11: Toxicological Information

Routes of Entry: Absorbed through skin. Inhalation. Ingestion.

Toxicity to Animals: Acute oral toxicity (LD50): 2660 mg/kg [Rat].

Chronic Effects on Humans:MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast. DEVELOPMENTAL TOXICITY: Classified Reproductivesystem/toxin/female, Reproductive system/toxin/male [POSSIBLE]. May cause damage to the following organs: kidneys,cardiovascular system, central nervous system (CNS).

Other Toxic Effects on Humans:Hazardous in case of skin contact (irritant), of ingestion, of inhalation. Slightly hazardous in case of skin contact (permeator).

Special Remarks on Toxicity to Animals: Not available.

Special Remarks on Chronic Effects on Humans:May cause adverse reproductive effects (fertility, fetoxicity) based on animal studies. May affect genetic material. May causeteratogenic effects based on animal studies.

Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: May cause skin irritation. May be absorbed throuogh damaged or abraded skin inharmful amounts. If absorbed through skin it may affect behavior, sense organs, metabolism, the gastrointestinal tract,and the respiratory tract (respiratory depression) Eyes: Dust causes eye irritation. Inhalation: Dust causes respiratory tractirritation. Ingestion: Causes digestive (gastrointestinal) tract irritation with nausea, vomiting and diarrhea. May also affectbehavior, brain, the Central Nervous System (depression, headache, dizziness, drowsiness, collapse, unconsciousness,coma), Peripheral Nervous System, cardiovascular system, blood, liver, urinary system (kidney, ureter, bladder) and endocrinesystem . Chronic Potential Health Effects: Boric acid can accumlate in the body (brain, bone) with repeated exposure.Prolonged or repeated skin contact may cause dermatitis. May cause borism characterized by dry skin, skin eruptions, andgastric disturbances.

Section 12: Ecological Information

Ecotoxicity: Not available.

BOD5 and COD: Not available.

Products of Biodegradation:Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise.

Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.

Special Remarks on the Products of Biodegradation: Not available.

Section 13: Disposal Considerations

p. 5

Waste Disposal:

Section 14: Transport Information

DOT Classification: Not a DOT controlled material (United States).

Identification: Not applicable.

Special Provisions for Transport: Not applicable.

Section 15: Other Regulatory Information

Federal and State Regulations: TSCA 8(b) inventory: Boric acid

Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).

Other Classifications:

WHMIS (Canada): CLASS D-2A: Material causing other toxic effects (VERY TOXIC).

DSCL (EEC):R36/38- Irritating to eyes and skin. R40- Possible risks of irreversible effects. R62- Possible risk of impaired fertility. S24/25-Avoid contact with skin and eyes.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 0

Reactivity: 0

Personal Protection: E

National Fire Protection Association (U.S.A.):

Health: 1

Flammability: 0

Reactivity: 0

Specific hazard:

Protective Equipment:Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Splash goggles.

Section 16: Other Information

References: Not available.

Other Special Considerations: Not available.

Created: 10/10/2005 08:15 PM

Last Updated: 05/21/2013 12:00 PM

The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or for

p. 6

lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.

SAFETY DATA SHEET




Page 1 of 13




Product name Sodium molybdate dihydrate for analysis EMSURE®






CAS-No. 10102-40-6








India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6


number


SAFETY DATA SHEET





Page 2 of 13




2.2 Label elements



2.3 Other hazards

None known.


3.1 Substance

Formula Na₂MoO₄ * 2 H₂O Na₂MoO₄ * 2 H₂O (Hill)

EC-No. 231-551-7



1907/2006.

3.2 Mixture

Not applicable




SAFETY DATA SHEET





Page 3 of 13


shower.




Nausea, Vomiting

Symptoms of an acute molybdenum(VI) intoxication: diarrhoea, anaemia (decreased

haemoglobin concentration in the blood), fatigue. Toxic effect on liver and kidneys after high

doses.







environment.




Not combustible.





Further information



SAFETY DATA SHEET





Page 4 of 13












of dusts.







Hygiene measures



Storage conditions




SAFETY DATA SHEET





Page 5 of 13









See section 7.1.





Eye/face protection

Safety glasses

Hand protection

full contact:




splash contact:







SAFETY DATA SHEET





Page 6 of 13

















Form crystals

Colour white

Odour odourless


pH 9 - 10

at 840 g/l

20 °C


SAFETY DATA SHEET





Page 7 of 13

Boiling point/boiling range Not applicable






Vapour pressure Not applicable


Density 2.71 g/cm3

at 22 °C



at 20 °C


octanol/water

Not applicable


Decomposition temperature 130 °C

Elimination of water of crystallisation



SAFETY DATA SHEET





Page 8 of 13


9.2 Other data

Bulk density 1,000 - 1,400 kg/m3


10.1 Reactivity

See section 10.3













Acute oral toxicity


(External MSDS)

Symptoms: Nausea, Vomiting

SAFETY DATA SHEET





Page 9 of 13




LD50 Rat: > 2,000 mg/kg

(External MSDS)

Skin irritation

Rabbit

Result: No irritation

(External MSDS)

Eye irritation

Rabbit

Result: slight irritation

(External MSDS)

Sensitisation

Sensitisation test: Guinea pig

Result: negative




Mutagenicity (mammal cell test): micronucleus.

Result: positive

(Lit.)


Mutagenicity (mammal cell test):

Result: positive

(Lit.)

Carcinogenicity


SAFETY DATA SHEET





Page 10 of 13



Teratogenicity






Aspiration hazard



Symptoms of an acute molybdenum(VI) intoxication: diarrhoea, anaemia (decreased

haemoglobin concentration in the blood), fatigue. Toxic effect on liver and kidneys after high

doses.

However, when the product is handled appropriately, hazardous effects are unlikely to occur.



12.1 Toxicity

Toxicity to fish

NOEC Oncorhynchus mykiss (rainbow trout): 3,200 mg/l; 96 h

(External MSDS)

LC50 Oncorhynchus mykiss (rainbow trout): 7,600 mg/l; 96 h

(External MSDS)

Toxicity to daphnia and other aquatic invertebrates

NOEC Daphnia magna (Water flea): 100 mg/l; 48 h

(External MSDS)

EC50 Daphnia magna (Water flea): 330 mg/l; 48 h

(External MSDS)

SAFETY DATA SHEET





Page 11 of 13

Toxicity to algae

NOEC Pseudokirchneriella subcapitata (green algae): 4.6 mg/l; 72 h

(External MSDS)

IC50 Pseudokirchneriella subcapitata (green algae): > 100 mg/l; 72 h

(External MSDS)


EC10 Pseudomonas putida: 50 mg/l; 18 h

(External MSDS)





Not applicable







SAFETY DATA SHEET





Page 12 of 13





the product itself.






regulations.


Not relevant



regulations.



regulations.


Not relevant





SAFETY DATA SHEET





Page 13 of 13




Training advice







1111. . . . Product and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationMaterial nameMaterial nameMaterial nameMaterial name ZINC SULFATE HEPTAHYDRATEZINC SULFATE HEPTAHYDRATEZINC SULFATE HEPTAHYDRATEZINC SULFATE HEPTAHYDRATEVersion #Version #Version #Version # 02Revision dateRevision dateRevision dateRevision date 08-30-2011CAS #CAS #CAS #CAS # 7446-20-0Product CodesProduct CodesProduct CodesProduct Codes J.T.Baker: 4382, 4383, 4384J.T.Baker: 4382, 4383, 4384J.T.Baker: 4382, 4383, 4384J.T.Baker: 4382, 4383, 4384

Macron: 8872, 8880Macron: 8872, 8880Macron: 8872, 8880Macron: 8872, 8880Synonym(s)Synonym(s)Synonym(s)Synonym(s) Sulfuric acid, zinc salt (1:1), heptahydrate





Suite #200


Harmful if inhaled or swallowed. Causes eye burns. Causes skin irritation. Dust or vapor irritatingto the eyes and respiratory tract.

OSHA regulatory statusOSHA regulatory statusOSHA regulatory statusOSHA regulatory status This product is considered hazardous under 29 CFR 1910.1200 (Hazard Communication).

Potential health effectsPotential health effectsPotential health effectsPotential health effectsRoutes of exposureRoutes of exposureRoutes of exposureRoutes of exposure Ingestion. Inhalation. Skin contact. Eye contact.EyesEyesEyesEyes Causes eye burns. Dust or splashes from the mixture may cause permanent eye damage.SkinSkinSkinSkin Causes skin irritation. Prolonged or repeated contact with skin may cause redness, itching,

irritation and eczema/chapping.InhalationInhalationInhalationInhalation Harmful if inhaled. Dust may irritate throat and respiratory system and cause coughing.IngestionIngestionIngestionIngestion Harmful if swallowed. Ingestion may cause gastrointestinal irritation, nausea, vomiting and

diarrhea.Target organsTarget organsTarget organsTarget organs Eyes. Skin. Respiratory system. Liver. Kidney.Chronic effectsChronic effectsChronic effectsChronic effects Prolonged or repeated exposure may cause liver and kidney damage. These effects have not

been observed in humans.

Potential environmental effectsPotential environmental effectsPotential environmental effectsPotential environmental effects Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.



7446-20-0 100ZINC SULFATE HEPTAHYDRATE



Eye contactEye contactEye contactEye contact Immediately flush with plenty of water for at least 15 minutes. If easy to do, remove contactlenses. Get medical attention. In case of irritation from airborne exposure, move to fresh air. Getmedical attention if irritation develops and persists.

Material name: ZINC SULFATE HEPTAHYDRATEMSDS ID: Z4560 Version #: 02 Revision date: 08-30-2011

MSDS US COV

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Skin contactSkin contactSkin contactSkin contact Immediately flush with plenty of water for at least 15 minutes while removing contaminatedclothing and shoes. Get medical attention. Wash clothing separately before reuse. Destroy orthoroughly clean contaminated shoes.

InhalationInhalationInhalationInhalation Move to fresh air. If breathing stops, provide artificial respiration. If breathing is difficult, giveoxygen. Get medical attention.

IngestionIngestionIngestionIngestion Call a physician or poison control center immediately. Only induce vomiting at the instruction ofmedical personnel. Never give anything by mouth to an unconscious person. If vomiting occurs,keep head low so that stomach content doesn't get into the lungs.

Notes to physicianNotes to physicianNotes to physicianNotes to physician Keep victim under observation. Treat symptomatically.General adviceGeneral adviceGeneral adviceGeneral advice In the case of accident or if you feel unwell, seek medical advice immediately (show the label

where possible). Show this safety data sheet to the doctor in attendance. Ensure that medicalpersonnel are aware of the material(s) involved, and take precautions to protect themselves.

5555. . . . Fire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFlammable propertiesFlammable propertiesFlammable propertiesFlammable properties The product is not flammable. No unusual fire or explosion hazards noted.


Water spray. Carbon dioxide (CO2). Dry chemical powder. Foam.


None known.

Protection of firefightersProtection of firefightersProtection of firefightersProtection of firefightersSpecific hazards arisingSpecific hazards arisingSpecific hazards arisingSpecific hazards arisingfrom the chemicalfrom the chemicalfrom the chemicalfrom the chemical

Fire may produce irritating, corrosive and/or toxic gases.

Protective equipment andProtective equipment andProtective equipment andProtective equipment andprecautions for firefightersprecautions for firefightersprecautions for firefightersprecautions for firefighters

Use water spray to cool unopened containers. Self-contained breathing apparatus and fullprotective clothing must be worn in case of fire. Cool containers exposed to flames with water untilwell after the fire is out.


Wear full protective clothing, including helmet, self-contained positive pressure or pressuredemand breathing apparatus, protective clothing and face mask. Wear self-contained breathingapparatus with a full facepiece operated in the positive pressure demand mode when fightingfires.

Specific methodsSpecific methodsSpecific methodsSpecific methods In the event of fire and/or explosion do not breathe fumes.

6666. . . . Accidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresPersonal precautionsPersonal precautionsPersonal precautionsPersonal precautions Keep unnecessary personnel away. Wear appropriate protective equipment and clothing during

clean-up. Keep upwind. Keep out of low areas. Ventilate closed spaces before entering them.Local authorities should be advised if significant spillages cannot be contained.

Environmental precautionsEnvironmental precautionsEnvironmental precautionsEnvironmental precautions Do not allow to enter drains, sewers or watercourses. Prevent further leakage or spillage if safe todo so.

Methods for containmentMethods for containmentMethods for containmentMethods for containment Prevent entry into waterways, sewers, basements or confined areas. Stop leak if you can do sowithout risk. Dike the spilled material, where this is possible.


Large Spills: Sweep up or vacuum up spillage and collect in suitable container for disposal.

Small Spills: Sweep up and place in a clearly labeled container for chemical waste. Clean surfacethoroughly to remove residual contamination.

Never return spills in original containers for re-use. Clean up in accordance with all applicableregulations. Collect in a non-combustible container for prompt disposal.

7777. . . . Handling and StorageHandling and StorageHandling and StorageHandling and StorageHandlingHandlingHandlingHandling Wear appropriate personal protective equipment. Avoid breathing dust. Do not get in eyes and

avoid contact with skin and clothing. Do not taste or swallow. Wash thoroughly after handling. Donot eat, drink or smoke when using the product. See Section 8 of the MSDS for PersonalProtective Equipment.


MSDS US COV

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StorageStorageStorageStorage Keep tightly closed in a dry, cool and well-ventilated place.

8888. . . . Exposure Controls Exposure Controls Exposure Controls Exposure Controls / / / / Personal ProtectionPersonal ProtectionPersonal ProtectionPersonal ProtectionEngineering controlsEngineering controlsEngineering controlsEngineering controls Good general ventilation (typically 10 air changes per hour) should be used. Ventilation rates

should be matched to conditions. If applicable, use process enclosures, local exhaust ventilation,or other engineering controls to maintain airborne levels below recommended exposure limits. Ifexposure limits have not been established, maintain airborne levels to an acceptable level.

Personal protective equipmentPersonal protective equipmentPersonal protective equipmentPersonal protective equipmentEye / face protectionEye / face protectionEye / face protectionEye / face protection Chemical goggles and face shield are recommended.Skin protectionSkin protectionSkin protectionSkin protection Wear appropriate chemical resistant clothing. Wear appropriate chemical resistant gloves.Respiratory protectionRespiratory protectionRespiratory protectionRespiratory protection If engineering controls do not maintain airborne concentrations below recommended exposure




GeneralGeneralGeneralGeneral Wear chemical protective equipment that is specifically recommended by the manufacturer.Launder contaminated clothing before reuse.

9999. . . . Physical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesAppearanceAppearanceAppearanceAppearance Crystalline. Granular.

ColorColorColorColor Colorless.




FormFormFormForm Solid.

pHpHpHpH 4.5 aqueous solution

Melting pointMelting pointMelting pointMelting point 212 °F (100 °C)

Freezing pointFreezing pointFreezing pointFreezing point 212 °F (100 °C)

Boiling pointBoiling pointBoiling pointBoiling point > 932 °F (> 500 °C) Decomposes.




Not available.


Not available.




Solubility (water)Solubility (water)Solubility (water)Solubility (water) 960 g/l


Not available



Molecular formulaMolecular formulaMolecular formulaMolecular formula O4-S-Zn.7H2O

10101010. . . . Chemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical stabilityChemical stabilityChemical stabilityChemical stability Stable under normal temperature conditions.Conditions to avoidConditions to avoidConditions to avoidConditions to avoid Excessive heat. Water, moisture.


MSDS US COV

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Incompatible materialsIncompatible materialsIncompatible materialsIncompatible materials Strong oxidizing agents. Inorganic salts.Hazardous decompositionHazardous decompositionHazardous decompositionHazardous decompositionproductsproductsproductsproducts

Zinc oxide. Sulfur oxides.





ProductProductProductProduct Test ResultsTest ResultsTest ResultsTest ResultsAcute Dermal LD50 Rat: > 2000 mg/kgZINC SULFATE HEPTAHYDRATE (7446-20-0)

Acute Oral LD50 Rat: 623 mg/kg


Acute effectsAcute effectsAcute effectsAcute effects Harmful if inhaled or swallowed.

Local effectsLocal effectsLocal effectsLocal effects Causes eye burns. Causes skin irritation. Inhalation of dusts may cause respiratory irritation.

Chronic effectsChronic effectsChronic effectsChronic effects Prolonged or repeated exposure may cause liver and kidney damage. These effects have notbeen observed in humans.


Skin corrosion/irritationSkin corrosion/irritationSkin corrosion/irritationSkin corrosion/irritation Causes skin irritation.



Neurological effectsNeurological effectsNeurological effectsNeurological effects No data available for this product.




Severe eye irritation. Moderate skin irritation. Upper respiratory tract irritation.




EC50 Water flea (Ceriodaphnia dubia): 0.06 mg/l 48.00 hoursZINC SULFATE HEPTAHYDRATE (7446-20-0)LC50 Rainbow trout,donaldson trout (Oncorhynchus mykiss):0.103 mg/l 96.00 hours

EcotoxicityEcotoxicityEcotoxicityEcotoxicity Expected to be very toxic to aquatic organisms. May cause long-term adverse effects in theenvironment. The product may affect the acidity (pH-factor) in water with risk of harmful effects toaquatic organisms.


The product is not readily biodegradable.


Not available

13131313. . . . Disposal ConsiderationsDisposal ConsiderationsDisposal ConsiderationsDisposal ConsiderationsDisposal instructionsDisposal instructionsDisposal instructionsDisposal instructions Dispose of this material and its container to hazardous or special waste collection point.

Incinerate the material under controlled conditions in an approved incinerator. All wastes must behandled in accordance with local, state and federal regulations.

Contaminated packagingContaminated packagingContaminated packagingContaminated packaging Since emptied containers retain product residue, follow label warnings even after container isemptied. Offer rinsed packaging material to local recycling facilities.


MSDS US COV

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Standard, 29 CFR 1910.1200.


US EPCRA (SARA Title III) Section 313 - Toxic Chemical: De minimis concentrationUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: De minimis concentrationUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: De minimis concentrationUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: De minimis concentrationZINC SULFATE HEPTAHYDRATE (CAS 7446-20-0) 1.0 % N982

US EPCRA (SARA Title III) Section 313 - Toxic Chemical: Listed substanceUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: Listed substanceUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: Listed substanceUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: Listed substanceZINC SULFATE HEPTAHYDRATE (CAS 7446-20-0) Listed. N982

CERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityZINC SULFATE HEPTAHYDRATE: 1000.0000




Yes

Clean Water Act (CWA)Clean Water Act (CWA)Clean Water Act (CWA)Clean Water Act (CWA) Hazardous substancePriority pollutantToxic pollutant





YesJapan Inventory of Existing and New Chemical Substances (ENCS)NoKorea Existing Chemicals List (ECL)

YesNew Zealand New Zealand InventoryYesPhilippines Philippine Inventory of Chemicals and Chemical Substances





MSDS US COV

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US - New Jersey Community RTK (EHS Survey): Reportable thresholdUS - New Jersey Community RTK (EHS Survey): Reportable thresholdUS - New Jersey Community RTK (EHS Survey): Reportable thresholdUS - New Jersey Community RTK (EHS Survey): Reportable thresholdZINC SULFATE HEPTAHYDRATE (CAS 7446-20-0) 500 LBS

US - Pennsylvania RTK - Hazardous Substances: Listed substanceUS - Pennsylvania RTK - Hazardous Substances: Listed substanceUS - Pennsylvania RTK - Hazardous Substances: Listed substanceUS - Pennsylvania RTK - Hazardous Substances: Listed substanceZINC SULFATE HEPTAHYDRATE (CAS 7446-20-0) Listed.

Saf-T-DataSaf-T-DataSaf-T-DataSaf-T-Data Health: 1 - SlightFlammability: 0 - NoneReactivity: 1 - SlightContact: 3 - SevereLab Protective Equip: D - GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPERGLOVESStorage Color Code: G - Green (General Storage)


Harmful if inhaled or swallowed. Causes eye burns. Causes skin irritation. Dust is irritating to theeyes and respiratory tract.

Label PrecautionsLabel PrecautionsLabel PrecautionsLabel Precautions Avoid breathing dust. Do not get in eyes and avoid contact with skin and clothing. Do not taste orswallow. Use only with adequate ventilation. Keep container closed. Wash thoroughly afterhandling.

Label First AidLabel First AidLabel First AidLabel First Aid Immediately flush eyes with plenty of water for at least 15 minutes. Immediately flush skin withplenty of water. If gas/fume/vapor/dust/mist from the material is inhaled, remove the affectedperson immediately to fresh air. Get medical attention immediately. IF SWALLOWED:Immediately call a POISON CENTER or doctor/physician. Do not induce vomiting without advicefrom poison control center. If vomiting occurs, keep head low so that stomach content doesn't getinto the lungs. Do not use mouth-to-mouth method if victim ingested the substance.






MSDS US COV

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SAFETY DATA SHEET




Page 1 of 16




Product name Iron(III) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph

Eur






CAS-No. 10025-77-1








India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6


number


SAFETY DATA SHEET



Product name Iron(III) chloride hexahydrate for analysis EMSURE® ACS,Reag. Ph Eur


Page 2 of 16





Skin irritation, Category 2, H315



2.2 Label elements


Hazard pictograms

Signal word

Danger

Hazard statements


H315 Causes skin irritation.



Prevention


Response





SAFETY DATA SHEET





Page 3 of 16


Hazard pictograms

Signal word

Danger

Hazard statements







CAS-No. 10025-77-1

2.3 Other hazards

None known.


3.1 Substance

Formula FeCl₃ * 6 H₂O Cl₃Fe * 6 H₂O (Hill)

EC-No. 231-729-4





iron(III) chloride hexahydrate (<= 100 % )

10025-77-1 *)




SAFETY DATA SHEET





Page 4 of 16





3.2 Mixture

Not applicable




After skin contact: wash off with plenty of water. Remove contaminated clothing.

After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist. Remove

contact lenses.


physician.


irritant effects, Nausea, Vomiting, cardiovascular disorders

Risk of serious damage to eyes.

The following applies to soluble iron compounds: nausea and vomiting after swallowing. The

absorption of large quantities is followed by cardiovascular disorders. Toxic effect on liver and

kidneys.





SAFETY DATA SHEET





Page 5 of 16



environment.




Not combustible.








Further information


Suppress (knock down) gases/vapours/mists with a water spray jet.



Advice for non-emergency personnel: Avoid substance contact. Avoid inhalation of dusts. Ensure


expert.







SAFETY DATA SHEET





Page 6 of 16








Hygiene measures




Requirements for storage areas and containers

No metal containers.

Storage conditions










SAFETY DATA SHEET





Page 7 of 16



See section 7.1.





Eye/face protection

Tightly fitting safety goggles

Hand protection

full contact:




splash contact:














protective clothing

SAFETY DATA SHEET





Page 8 of 16



Recommended Filter type: Filter B-(P2)








Form solid

Colour tan

Odour of chlorine


pH ca. 1.8

at 10 g/l

25 °C





SAFETY DATA SHEET





Page 9 of 16









at 20 °C


octanol/water







9.2 Other data


Bulk density ca.600 - 1,200 kg/m3

SAFETY DATA SHEET





Page 10 of 16


10.1 Reactivity

Corrosive in contact with metals


sensitive to moisture



Alkali metals, Ethylene oxide



Exposure to moisture


Metals, Mild steel





Acute oral toxicity

LD50 Rat: 316 mg/kg

(anhydrous substance) (RTECS)

Symptoms: Nausea, Vomiting, Irritations of mucous membranes in the mouth, pharynx,

oesophagus and gastrointestinal tract.


Symptoms: Possible damages:, Irritation symptoms in the respiratory tract.

SAFETY DATA SHEET





Page 11 of 16


LD50 Dermal Rat: > 2,000 mg/kg

(External MSDS) (anhydrous substance)

Skin irritation

Rabbit

Result: Irritations

(anhydrous substance) (IUCLID)

Causes skin irritation.

Eye irritation

Rabbit

Result: Severe irritations


(anhydrous substance)


Sensitisation




In vivo micronucleus test

Mouse

Result: negative



Ames test

Result: negative



SAFETY DATA SHEET





Page 12 of 16


Result: negative



Carcinogenicity




Teratogenicity






Aspiration hazard



After absorption of large quantities:

cardiovascular disorders

Toxic effect on:

Liver, Kidney




12.1 Toxicity

Toxicity to fish

LC50 Lepomis macrochirus (Bluegill sunfish): 20.3 mg/l; 96 h


SAFETY DATA SHEET





Page 13 of 16


Immobilization EC50 Daphnia magna (Water flea): 9.6 mg/l; 48 h



Toxicity to algae

ErC50 Pseudokirchneriella subcapitata (green algae): 6.9 mg/l; 72 h






Toxicity to fish (Chronic toxicity)

NOEC Pimephales promelas (fathead minnow): 0.33 mg/l; 33 d


Toxicity to daphnia and other aquatic invertebrates (Chronic toxicity)

NOEC Daphnia magna (Water flea): 0.7 mg/l; 21 d



Biodegradability


substances.









Product reacts with water.

The following may develop after reaction of the product with water:

SAFETY DATA SHEET





Page 14 of 16

hydrochloric acid






the product itself.






regulations.


Not relevant



regulations.



regulations.


Not relevant



SAFETY DATA SHEET





Page 15 of 16










Training advice


Labelling

Hazard pictograms

Signal word

Danger

Hazard statements





Prevention


Response

SAFETY DATA SHEET





Page 16 of 16









Sigma-Aldrich - I6758 Page 1 of 7





1.1 Product identifiers Product name : Isopropyl β-D-1-thiogalactopyranoside

Product Number : I6758 Brand : Sigma-Aldrich REACH No. : A registration number is not available for this substance as the substance


CAS-No. : 367-93-1










2.2 Label elements

Labelling according Regulation (EC) No 1272/2008 Pictogram none Signal word none Hazard statement(s) none Precautionary statement(s) none Supplemental Hazard Statements

none

Safety data sheet available on request.

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.



3.2 Mixtures Synonyms : Isopropyl β-D-thiogalactoside

IPTG

Formula : C9H18O5S

Molecular weight : 238.3 g/mol No components need to be disclosed according to the applicable regulations.













5.2 Special hazards arising from the substance or mixture Carbon oxides, Sulphur oxides





6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.





7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Recommended storage temperature 2 - 8 °C

hygroscopic Storage class (TRGS 510): Combustible Solids







Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.


Body Protection Impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (EN 143) respirator cartridges as a backup to engineering controls. If th full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains.



a) Appearance Form: solid





105 °C


No data available





No data available






No data available


No data available


No data available










10.4 Conditions to avoid Exposure to moisture


10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Sulphur oxides Other decomposition products - No data available In the event of fire: see section 5



Acute toxicity No data availableIsopropyl-β-D-thiogalactopyranoside

Skin corrosion/irritation No data available(Isopropyl-β-D-thiogalactopyranoside)

Serious eye damage/eye irritation No data available(Isopropyl-β-D-thiogalactopyranoside)

Respiratory or skin sensitisation No data available(Isopropyl-β-D-thiogalactopyranoside)

Germ cell mutagenicity No data available(Isopropyl-β-D-thiogalactopyranoside)

Carcinogenicity

IARC: 2B - Group 2B: Possibly carcinogenic to humans (1,4-Dioxane)


No data available(Isopropyl-β-D-thiogalactopyranoside)

Specific target organ toxicity - single exposure No data available(Isopropyl-β-D-thiogalactopyranoside)


Aspiration hazard No data available(Isopropyl-β-D-thiogalactopyranoside)

Additional Information RTECS: Not available To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Isopropyl-β-D-thiogalactopyranoside)






12.4 Mobility in soil No data available(Isopropyl-β-D-thiogalactopyranoside)




















© 2015 Sigma-Aldrich Co. LLC. All rights reserved. SIGMA-ALDRICH is a trademark of Sigma-Aldrich Co. LLC, registered in the US and other countries. Aldrich brand products are sold through Sigma-Aldrich, Inc. Purchaser must determine the suitability of the product(s) for their particular use. Additional terms and conditions may apply. Please see product information on the Sigma-Aldrich website at www.sigmaaldrich.com and/or on

the reverse side of the invoice or packing slip.

85390 Silicon Antifoam Characteristics SILICONE ANTIFOAM, which contains 20 % active ingredient and 33 % solids, is a versatile antifoam that is comparatively rich in emulsifier but is nonetheless easily metered because it has a relatively low viscosity. Since SILICONE ANTIFOAM also possesses high resistance to alkalis and acids, it may further be used in a wide range of applications in which pH is critical. Application SILICONE ANTIFOAM has proved ideal for tackling foam in textile auxiliaries and processes, for incorporation into cooling lubricants based on mineral oils, for separation of monomers from dispersions and conversion of dispersion into derivatives. SILICONE ANTIFOAM is a useful auxiliary for combating foam generated in surfactant containing formulations employed in the most diverse areas, such as the agrochemicals (plant protection agents), cleaners and petrochemicals industries. SILICONE ANTIFOAM is also an efficient defoamer for treating wastewaster. Processing As SILICONE ANTIFOAM is a low-viscosity emulsion, it can be metered readily, with stable dispersions easily attainable in high-viscosity formulations. In low viscosity products, preliminary compatibility and stability tests should be performed on the system to be de-foamed. The amount to add to liquid formulations depends on the desired degree of foam control, but usually lies between 0.1 and 2 %. If SILICONE ANTIFOAM is to be added during a process, we recommend pre-diluting it with cold water in a ratio of 1:1 to 1:10. If feed pumps are used, they should be of the low shear force type. Storage SILICONE ANTIFOAM has a recommended retest period of 16 months when stored at room temperature in the tightly closed original container. The recommended retest date of each lot appears on the respective Certificate of Analysis. Storage beyond the date specified on the label does not necessarily mean that the product is no longer usable. In this case however, the properties required for the intended use must be checked for quality assurance reasons. Product data

Property Method Unit Value Appearance white Active content, approx. [%] 20 Solids content, approx. microwave oven [%] 33 Ionic nature Nonionic Viscosity (25 °C), approx. spindle 1, 50 rpm [mPa s] 150 pH, approx. indicator strips 5.0–8.0 Density (25 °C), approx. DIN 12791 [g/mL] 1.0

These figures are only intended as a guide and should not be used in preparing specifications. They refer to manufacturer information. Precautions and Disclaimer This product is for R&D use only, not for drug, household, or other uses. Please consult the Material Safety Data Sheet for information regarding hazards and safe handling practices.

Thiamine Hydrochloride

Products Covered :

Section 1 – Product Information

Product Regulatory Data Sheet

A number of the cGMP produced products that are sold by Avantor Performance Materials, LLC. may not be originally manufactured at our sites. However, we perform the analytical and stability testing for these products and repackage the products where applicable. With ISO and cGMP procedures in place at our facilities we can ensure, and take complete responsibility for, the traceability and quality of the finished, packaged product that we offer.

The original manufacturer and address will be referenced on the Certificate of Analysis as an alpha or alpha-numeric manufacturer code rather than listing the full name and address. This practice is compliant with both ICH Q7 Good Manufacturing Guidance for Active Pharmaceutical Ingredients (APIs) and IPEC guidelines and it meets cGMP requirements. For instructions to decipher the manufacturer reference code please consult our website. Instructions can be found in the Ask Avantor QA Center of the support section of our web site or by directly linking to Ask Avantor Keyword: Manufacturer Code.

Section 2 – Manufacturing, Packaging and Release Site Information

*MOC = Management of Change

The products in Section 1 are manufactured according to current Good Manufacturing Practices (cGMPs) as set forth by International Pharmaceutical Excipients Council (IPEC) guidelines.

Brand Product Code Product Description MOC*

J.T.Baker® 4110 Thiamine Hydrochloride, U.S.P. - F.C.C. R

Macron Fine Chemicals™

2722 Thiamine Hydrochloride, U.S.P. R

Page 1 of 5Rev. 5; November 15, 2017 Thiamine Hydrochloride

67-03-8CAS #:

Section 3 – Physical/Chemical Information

Manufacturing Process:

Synthesis

Raw Material Origin:

Chemical

Section 4 – Regulatory Information

Please see the current product specifications at www.AvantorInc.com.

DMF:

BSE/TSE Status:

The products listed do not contain cereals containing gluten (i.e. wheat, rye, oats, barley, spelt, kamut or their hybridized strains), malt, triticale, gluten, other grains, corn, soy, soybeans, eggs, yeast, canola, milk, dairy products, fish, crustacean shellfish, seafood products, tree nuts, peanuts, nut products (i.e. Almond (Amygdalus communis L.), Hazelnut (Corylus avellana), Walnut (Juglans regia), Cashew (Anacardium occidentale), Pecan nut (Carya illiniesis (Wangenh.) K. Koch), Brazil nut (Bertholletia excelsa), Pistachio nut (Pistacia vera), Macadamia nut and Queensland nut (Macadamia ternifolia)), seed products (sesame seeds and products thereof), natural grape products, natural flavors, artificial flavors, celery, mustard, lactose, sulfites, elemental sulfur, preservatives, lupine and products thereof, MSG, disodium guanylate/inosinate, artificial sweeteners, phenylalanine, additives, colorants, dyes, or natural rubber (latex). These products are manufactured using cGMP guidelines which provide controls that allow no potential for cross contamination of any allergens or other products.

The subject materials, including any raw materials and processing aids, are NOT subject to genetic modification.

Only Class 3 solvent (Ethanol) is likely to be present. All are below Option 1 limits. No other Class 1, 2, 3, or other Residual Solvents, as described in USP <467>, are used or produced during manufacture.

Please see attached summary for Elemental Impurity information for listed products.

Allergen/Hypersensitivities Information:

GMO Information:

Residual Solvents/Organic Volatile Impurities (OVI) Information:

The subject materials are manufactured from raw materials that contain NO animal parts, products, and/or by-products nor do they come in contact with animal parts, products, and/or by-products.

Aflatoxins as defined by IPEC (International Pharmaceutical Excipient Council) are a group of structurally related toxic compounds produced by certain strains of the fungi Aspergillus flavus and A. parasiticus. Under favorable conditions of temperature and humidity, these fungi grow on certain foods and feeds, resulting in the production of aflatoxins. The most pronounced contamination has been encountered in tree nuts, peanuts, and other oilseeds, including corn and cottonseed. Aflatoxicosis is poisoning that results from ingestion of aflatoxins in contaminated food or feed.

Avantor does not analyze the product(s) for the presence of aflatoxin content. However, we can confirm the subject materials do not contain, nor are they manufactured with any product commonly affected by aflatoxins. These

Aflatoxins:

Avantor Performance Materials, LLC. Does not carry a Drug Master File for these products.

Elemental Impurities:

Compendial Compliance:


Kosher Status:

The subject materials are not Kosher Certified.

Halal Status:

The subject materials are not Halal Certified.

include cereals (maize, sorghum, pearl millet, rice, wheat), oilseeds (peanut, soybean, sunflower, cotton), spices (chili peppers, black pepper, coriander, turmeric, ginger), and tree nuts (almond, pistachio, walnut, coconut, Brazil nut)

GRAS Status:

The United States Food and Drug Administration (FDA) have acknowledged that thiamine hydrochloride is a Direct Food Substances Affirmed As Generally Recognized as Safe (GRAS) in foods when used in accordance with the requirements and limitations per 21 CFR parts 184.1875.

Please refer to the customer support section of our website for our most up to date listing of Kosher products. (Ask Avantor Keyword: Kosher)

Please refer to the customer support section of our website for our most up to date listing of Halal products. (Ask Avantor Keyword: Halal)


Section 5 – Miscellaneous Product Information

reported as YYYY/MM/DD from our ERP system effective April 30, 2012. For example, the Manufactured Date for October 1, 2012 would be reported as 2012/10/01

information concerning our lot/batch numbering system. (Ask Avantor Keyword: Lot Number)

batch of the source supplier.

If a product has an assigned expiration or retest period, the date will appear on the

Bulk food chemicals that are intended for the use in manufacturing of finished food products or for products that Bulk food chemicals that are intended for use in manufacturing of finished food products or for products that are to be processed, labeled, and/or repacked at a site other than where it's orginally processed or packed, are exempt from the Nutrient Content Evaluation and Labeling Requirements. (21 CFR 101.9(j)(9))

Please refer to the customer support section of our website for information concerning

Country of Origin is indicated on the product Certificate of Analysis. Please contact

of specific storage conditions listed on the Avantor specification sheet or certificate of analysis, our products are to be stored in ambient conditions of temperature and humidity. We do not formally tie any specific temperature or humidity range with the ‘ambient’ storage designation, but an example of a common temperature interpretation is 15-30°C. Our products are also packaged to protect from the normal variation in humidity during storage and shipment. Further handling and storage information may be found in Section 7 of the product SDS sheet.

Rev. 0; Oct. 1, 2007 – IPEC EIP format (DRH)Rev. 1; Jan. 2, 2009 - Section 4: Residual Solvents statement revised; Section 7: updated telephone # for Customer Service Director; Entire Document: added keywords to Solv It Center links. (KES)Rev. 2; Jan. 13, 2010 – Entire document: new letterhead and changed all references of “Solv IT Center” to “AskMBI.”; Section 7: updated TS manager info. Section 4: added GRAS section (KES)Rev. 3; Nov. 8, 2011 –Entire document: new letterhead (company name & headquarters address); changed all references of “AskMBI” to “AskAvantor”; updated website links to new website; minor formatting; Section 1: Mallinckrodt brand name changed to Macron; added MOC code; Section 2: added GMP statement; Section 4: expanded Allergens list; added Residual Metallic Catalysts Information; Section 5: Added Nutritional/Supplemental Facts Labeling and Organic Status statements; Section 7: updated contact information. (PH/JLW)Rev. 4; Aug. 12, 2013 –Section 4: added add’l allergens as listed in EU Directive 2003/89/EC; separated Kosher/Halal

Section 6 – Revision History

The Manufactured Date and Expiration/Retest Date on the C of A are

Please refer to the customer support section of our website for

A “batch” is a homogeneous unit of production; each batch of material is from one single

certificate of analysis. For products that do not have assigned dates please contact Technical Support through the customer support section of our website for our product stability profiles. (Ask Avantor Keyword: Expiration)

our Management of Change program. (Ask Avantor Keyword: MOC)

our Trade Compliance Department if you require further documentation. ([email protected])

Please refer to the product Certificate of Analysis/Product Specifications. In the absenceStorage Requirements:

Country of Origin Statement:

Management of Change:

Shelf Life Information:

Batch Definition:

Lot Numbering System and Batch Description:

Certificate of Analysis Date Format:

Nutritional/Supplement Facts Labeling:

Organic Status:The products listed in Section 1 are not certified as organic. However, to the best of our knowledge, the product is not produced using Ionizing Radiation as described in 21 CFR 179.26 or Sewage Sludge as described in 7 CFR Section 205.2.


status and added certification statement; Section 5: added Management of Change information; Added COA Date Format statement Section 7: removed contact list table and added CS/TS contact information. (MCH)Rev.5; November 15, 2017- Entire document: new letterhead format (company name and headquarters address); Section4: updated residual solvent statement and added Elemental Impurities information, added Aflatoxin Statement; Section 5: added Storage Requirement, Batch Definition, and Country of Origin Statements (SR)

This electronic document is valid without a signature.

Section 7 – Contact Information

Customer Service Phone: 1-855-282-6867 1-610-573-2600 (outside U.S.) Fax: 1-610-573-2650 [email protected]

Technical Service Phone: 1-855-282-6867 1-610-573-2600 (outside U.S.) Fax: 1-610-573-2650 [email protected]

Trademarks are owned by Avantor Performance Materials, LLC. or its affiliates unless otherwise noted.© 2017 Avantor Performance Materials, LLC.

The most current revision of this document is maintained on our website. Reviews and revisions are performed as warranted due to product changes or as part of the supplier audit cycle.

While the above information is provided in good faith and believed to be accurate as of the date provided, Avantor Performance Materials, LLC and its affiliated companies ("Avantor") make no representations or warranties as to the accuracy or completeness of such information. Use of the information is subject to Avantor's confidentiality requirements as applicable. All Avantor products are subject to Avantor’s terms and conditions of sale including the limitations of liability contained therein and any contrary terms and conditions are expressly rejected. As Avantor has no control over purchasers’ uses of its products or information, Avantor expressly disclaims all liability with respect to same.


Page 1 of 4

Material Name: Thiamine Hydrochloride Product codes: : 4110, 2722 Date: January 4, 2017

Source/Type of Excipient: ☐ Mineral; ☐ Mineral derived; ☐ Plant; ☐ Plant derived; ☒ Synthetic; ☐ Fermentation derived

Other (explain):

Elemental Impurity

Class Likely to be Present

If Known, Please Identify the Expected

Concentration /Units (or Range)

Analytical Method Used (and Limit of Detection if

Available)

Comments regarding source of information (i.e.;

number of lots tested, frequency of testing,

process understanding, etc.)

Arsenic (inorganic)

As 1 Yes No Unknown <0.1 ppm ICP-OES (MRL=0.1 ppm) Manufacturer supplied information

Cadmium Cd 1 Yes No Unknown <0.1 ppm ICP-OES (MRL=0.1 ppm) Manufacturer supplied information

Mercury (inorganic)

Hg 1 Yes No Unknown <0.01 ppm Fluorescence (MRL=0.01 ppm)

Manufacturer supplied information

Lead Pb 1 Yes No Unknown <0.1 ppm ICP-OES (MRL=0.1 ppm) Manufacturer supplied information

Cobalt Co 2A Yes No Unknown <0.1 ppm ICP-OES (MRL=0.1 ppm) Manufacturer supplied information

Nickel Ni 2A Yes No Unknown <0.2 ppm ICP-OES (MRL=0.2 ppm) Manufacturer supplied

Page 2 of 4

Elemental Impurity





Available)




information

Vanadium V 2A Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information

Silver Ag 2B Yes No Unknown Not tested Manufacturer supplied information

Gold Au 2B Yes No Unknown Not tested Manufacturer supplied information

Iridium Ir 2B Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information

Osmium Os 2B Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information

Palladium Pd 2B Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information

Platinum Pt 2B Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information

Rhodium Rh 2B Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information

Ruthenium Ru 2B Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information

Selenium Se 2B Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information

Thallium Tl 2B Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information

Barium Ba 3 Yes No Unknown N/A Manufacturer supplied information

Page 3 of 4

Elemental Impurity





Available)




Chromium Cr 3 Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information

Copper Cu 3 Yes No Unknown <0.4 ppm ICP-OES (MRL=0.4 ppm) Manufacturer supplied information

Lithium Li 3 Yes No Unknown Not tested. Manufacturer supplied information

Molybdenum Mo 3 Yes No Unknown <1 ppm ICP-OES (MRL=1 ppm) Manufacturer supplied information

Antimony Sb 3 Yes No Unknown <0.1 ppm ICP-OES (MRL=0.1 ppm) Manufacturer supplied information

Tin Sn 3 Yes No Unknown Not tested. Manufacturer supplied information

Reference: ICH Q3D Guideline for Elemental Impurities, Step 4 version, September 2014

David L. Cugini, Sr. QA Analyst

Prepared by the Technical Service Department Avantor™ Performance Materials, Inc. 3477 Corporate Parkway Suite #200

Center Valley, PA 18034 1-800-669-8230

Avantor™ Performance Materials, Inc provides the information contained herein in good faith but makes no representations or warranties, either expressed or implied, including without limitation any warranties of merchantability or fitness for a particular purpose with respect to the information set forth herein or the product(s) to which the information refers. Accordingly, Avantor™ Performance Materials, Inc will not be responsible for damages resulting from the use of or reliance upon this information.

Page 4 of 4

Trademarks are owned by Avantor Performance Materials, Inc. or its affiliates unless otherwise noted. © 2016 Avantor Performance Materials, Inc.

SAFETY DATA SHEET




Page 1 of 17




Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE®

ACS,Reag. Ph Eur,ISO






CAS-No. 1310-73-2


Identified uses Reagent for analysis, Chemical production






India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6


number


SAFETY DATA SHEET



Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE® ACS,Reag.

Ph Eur,ISO


Page 2 of 17




Corrosive to metals, Category 1, H290

Skin corrosion, Category 1A, H314


2.2 Label elements


Hazard pictograms

Signal word

Danger

Hazard statements

H290 May be corrosive to metals.

H314 Causes severe skin burns and eye damage.


Prevention

P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.

Response

P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.



P308 + P310 IF exposed or concerned: immediately call a POISON CENTER or doctor/ physician.

SAFETY DATA SHEET




Ph Eur,ISO


Page 3 of 17


Hazard pictograms

Signal word

Danger

Hazard statements








CAS-No. 1310-73-2

2.3 Other hazards

None known.


3.1 Substance

Formula NaOH HNaO (Hill)

EC-No. 215-185-5





sodium hydroxide (<= 100 % )

PBT/vPvB: Not applicable for inorganic substances

1310-73-2 *)

SAFETY DATA SHEET




Ph Eur,ISO


Page 4 of 17







3.2 Mixture

Not applicable



General advice




shower. Call a physician immediately.


contact lenses.

After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of

perforation). Call a physician immediately. Do not attempt to neutralise.


Risk of blindness!

Irritation and corrosion, Cough, Shortness of breath, collapse, death



SAFETY DATA SHEET




Ph Eur,ISO


Page 5 of 17





environment.




Not combustible.






Further information







expert.





SAFETY DATA SHEET




Ph Eur,ISO


Page 6 of 17




of dusts.







Hygiene measures





No aluminium, tin, or zinc containers.


Storage conditions







SAFETY DATA SHEET




Ph Eur,ISO


Page 7 of 17

sodium hydroxide (1310-73-2)

IN OEL Ceiling Limit Value: 2 mg/m³





See section 7.1.





Eye/face protection


Hand protection

full contact:




splash contact:









SAFETY DATA SHEET




Ph Eur,ISO


Page 8 of 17






protective clothing




substances








Form solid

Colour white

Odour odourless


pH ca. > 14

at 100 g/l

20 °C

SAFETY DATA SHEET




Ph Eur,ISO


Page 9 of 17

Melting point/range 319 - 322 °C

Boiling point/boiling range 1,390 °C

at 1,013 hPa







Not applicable


Density 2.13 g/cm3

at 20 °C


Water solubility 1,090 g/l

at 20 °C


octanol/water




SAFETY DATA SHEET




Ph Eur,ISO


Page 10 of 17




9.2 Other data




10.1 Reactivity

See section 10.3


hygroscopic



Acetone, Chlorine, Ethylene oxide, Fluorine, Hydrogen halides, Hydrazine hydrate,

hydroxylamine, Acid anhydrides, Acrolein, Acid chlorides, Acids, sulphuric acid, Chloroform,

Water, hydrogen peroxide, anhydrides, EPICHLOROHYDRIN, phosphides, halogen-halogen

compounds, trichloroethene, ALLYL ALCOHOL

can decompose violently in contact with:

Organic Substances, hydrogen sulphide


powdered aluminium, Ammonium salts, persulfates, Sodium borohydride, phosphorus, Oxides of

phosphorus, Halogenated hydrocarbon, Light metals, Metals

Risk of explosion/exothermic reaction with:

SAFETY DATA SHEET




Ph Eur,ISO


Page 11 of 17

Bromine, Calcium, in powder form, furfuryl alcohol, Nitromethane, Peroxides, organic nitro

compounds, Nitriles, Acrylic monomers, SILVER NITRATE

Chloroform, with, Acetone

Nitrobenzene, with, Methanol

Nitrobenzene, with, salts

magnesium, Zinc, and, Tin, (in the presence of atmospheric oxygen and/or moisture)


Moisture.


Aluminium, brass, Metals, metal alloys, Zinc, Tin





Acute oral toxicity

Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation

of the oesophagus and the stomach.


Symptoms: burns of mucous membranes, Cough, Shortness of breath, Possible damages:,

damage of respiratory tract



SAFETY DATA SHEET




Ph Eur,ISO


Page 12 of 17

Skin irritation

Rabbit

Result: Causes burns.

(External MSDS)

Causes severe burns.

Eye irritation

Rabbit

Result: Irreversible effects on the eye

(ECHA)


Risk of blindness!

Sensitisation

Patch test: human

Result: negative

(ECHA)




Result: negative

(Lit.)

Ames test

Result: negative

(IUCLID)

Carcinogenicity




SAFETY DATA SHEET




Ph Eur,ISO


Page 13 of 17

Teratogenicity






Aspiration hazard



Systemic effects:

collapse, death




12.1 Toxicity

Toxicity to fish

LC50 Gambusia affinis (Mosquito fish): 125 mg/l; 96 h

(External MSDS)


EC50 Ceriodaphnia (water flea): 40.4 mg/l; 48 h

(ECHA)


EC50 Photobacterium phosphoreum: 22 mg/l; 15 min

(External MSDS)


Biodegradability


substances.


SAFETY DATA SHEET




Ph Eur,ISO


Page 14 of 17








Harmful effect due to pH shift.

Forms corrosive mixtures with water even if diluted.

Neutralisation possible in waste water treatment plants.


SAFETY DATA SHEET




Ph Eur,ISO


Page 15 of 17





the product itself.






14.2 Proper shipping name SODIUM HYDROXIDE, SOLID

14.3 Class 8

14.4 Packing group II

14.5 Environmentally hazardous --


user

yes



Not relevant




14.3 Class 8



SAFETY DATA SHEET




Ph Eur,ISO


Page 16 of 17


user

no




14.3 Class 8




user

yes

EmS F-A S-B


Not relevant




Storage class 8B







Training advice

SAFETY DATA SHEET




Ph Eur,ISO


Page 17 of 17


Labelling

Hazard pictograms

Signal word

Danger

Hazard statements




Prevention


Response










1111. . . . Product and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationMaterial nameMaterial nameMaterial nameMaterial name TOLUENETOLUENETOLUENETOLUENEVersion #Version #Version #Version # 02Revision dateRevision dateRevision dateRevision date 08-30-2011Chemical nameChemical nameChemical nameChemical name TOLUENECAS #CAS #CAS #CAS # 108-88-3Product CodesProduct CodesProduct CodesProduct Codes J.T.Baker: 5375, 5584, 5812, 9336, 9351, 9364, 9456, 9457, 9459, 9460, 9462, 9466, 9472,J.T.Baker: 5375, 5584, 5812, 9336, 9351, 9364, 9456, 9457, 9459, 9460, 9462, 9466, 9472,J.T.Baker: 5375, 5584, 5812, 9336, 9351, 9364, 9456, 9457, 9459, 9460, 9462, 9466, 9472,J.T.Baker: 5375, 5584, 5812, 9336, 9351, 9364, 9456, 9457, 9459, 9460, 9462, 9466, 9472,

9476947694769476Macron: 4483, 8604, 8608, V560Macron: 4483, 8604, 8608, V560Macron: 4483, 8604, 8608, V560Macron: 4483, 8604, 8608, V560

Synonym(s)Synonym(s)Synonym(s)Synonym(s) Methylbenzene; Toluol; PhenylmethaneManufacturer informationManufacturer informationManufacturer informationManufacturer information Avantor Performance Materials, Inc.

3477 Corporate ParkwaySuite #200Center Valley, PA 18034 US24 Hour Emergency 908-859-2151Chemtrec 800-424-9300Customer Service 855-282-6867


Flammable liquid and vapor. Will be easily ignited by heat, spark or flames. Harmful if inhaled orabsorbed through skin. Harmful or fatal if swallowed. Causes skin and eye irritation. Causesrespiratory tract irritation. High vapor concentrations may cause drowsiness and irritation of theeyes or respiratory tract. May damage fertility or the unborn child. Prolonged exposure may causechronic effects.

Potential health effectsPotential health effectsPotential health effectsPotential health effectsRoutes of exposureRoutes of exposureRoutes of exposureRoutes of exposure Inhalation. Ingestion. Skin contact. Eye contact.EyesEyesEyesEyes Causes eye irritation. High vapor/aerosol concentrations may be irritating.SkinSkinSkinSkin Harmful if absorbed through skin. Causes skin irritation. Prolonged or repeated contact with skin

may cause redness, itching, irritation and eczema/chapping.InhalationInhalationInhalationInhalation Harmful if inhaled. May cause irritation to the mucous membranes and upper respiratory tract. In

high concentrations, vapors and aerosol mists have a narcotic effect and may cause headache,fatigue, dizziness and nausea.

IngestionIngestionIngestionIngestion Harmful or fatal if swallowed. Ingestion may result in vomiting; aspiration (breathing) of vomitusinto lungs must be avoided as even small quantities may result in aspiration pneumonitis.

Target organsTarget organsTarget organsTarget organs Eyes. Respiratory system. Skin. Nervous System. Reproductive organs. Kidneys. Auditoryorgans.

Chronic effectsChronic effectsChronic effectsChronic effects Can cause nervous system damage. May cause adverse reproductive effects - such as birthdefects, miscarriages, or infertility based on animal data. Frequent or prolonged contact may defatand dry the skin, leading to discomfort and dermatitis.

Potential environmental effectsPotential environmental effectsPotential environmental effectsPotential environmental effects Toxic to aquatic organisms.



108-88-3 99 - 100TOLUENE

Material name: TOLUENEMSDS ID: T3913 Version #: 02 Revision date: 08-30-2011

MSDS CANADA

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Eye contactEye contactEye contactEye contact Immediately flush with plenty of water for at least 15 minutes. If easy to do, remove contactlenses. Get medical attention.

Skin contactSkin contactSkin contactSkin contact In case of contact, immediately flush skin with plenty of water for at least 15 minutes whileremoving contaminated clothing and shoes. Get medical attention. Wash contaminated clothingbefore reuse. Destroy or thoroughly clean contaminated shoes.

InhalationInhalationInhalationInhalation Move to fresh air. If breathing is difficult, give oxygen. If breathing stops, provide artificialrespiration. Get medical attention immediately.

IngestionIngestionIngestionIngestion Call a physician or poison control center immediately. Do not induce vomiting. If vomiting occurs,the head should be kept low so that stomach vomit doesn't enter the lungs.

Notes to physicianNotes to physicianNotes to physicianNotes to physician Treat symptomatically. Symptoms may be delayed.General adviceGeneral adviceGeneral adviceGeneral advice Ensure that medical personnel are aware of the material(s) involved, and take precautions to


5555. . . . Fire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFlammable propertiesFlammable propertiesFlammable propertiesFlammable properties HIGHLY FLAMMABLE! Vapors may cause a flash fire or ignite explosively. Vapors may travel

considerable distance to a source of ignition and flash back. Heat may cause the containers toexplode.


Water spray. Foam. Dry powder. Carbon dioxide (CO2).


Do not use water jet as an extinguisher, as this will spread the fire.


Can be ignited easily and burns vigorously. Vapor from the solvent may accumulate in containerheadspace resulting in flammability hazard.

Protective equipment forProtective equipment forProtective equipment forProtective equipment forfirefightersfirefightersfirefightersfirefighters


Fire fightingFire fightingFire fightingFire fightingequipment/instructionsequipment/instructionsequipment/instructionsequipment/instructions

Firefighters must use standard protective equipment including flame retardant coat, helmet withface shield, gloves, rubber boots, and in enclosed spaces, SCBA. Withdraw immediately in caseof rising sound from venting safety device or any discoloration of tanks due to fire. Movecontainers from fire area if you can do so without risk. For massive fire in cargo area, useunmanned hose holder or monitor nozzles, if possible. If not, withdraw and let fire burn out. Someof these materials, if spilled, may evaporate leaving a flammable residue. Cool containersexposed to flames with water until well after the fire is out.

Specific methodsSpecific methodsSpecific methodsSpecific methods In the event of fire and/or explosion do not breathe fumes. Use water spray to cool unopenedcontainers.

Hazardous combustion productsHazardous combustion productsHazardous combustion productsHazardous combustion products Carbon monoxide and carbon dioxide.

6666. . . . Accidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresPersonal precautionsPersonal precautionsPersonal precautionsPersonal precautions Wear appropriate protective equipment and clothing during clean-up. Keep unnecessary

personnel away. Keep upwind. Keep out of low areas. Ventilate closed spaces before enteringthem. Do not touch damaged containers or spilled material unless wearing appropriate protectiveclothing. Local authorities should be advised if significant spillages cannot be contained.

Environmental precautionsEnvironmental precautionsEnvironmental precautionsEnvironmental precautions Prevent further leakage or spillage if safe to do so. Do not contaminate water. Avoid dischargeinto drains, water courses or onto the ground.

Methods for containmentMethods for containmentMethods for containmentMethods for containment ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Stop theflow of material, if this is without risk. Prevent entry into waterways, sewer, basements or confinedareas. Dike the spilled material, where this is possible.


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Methods for cleaning upMethods for cleaning upMethods for cleaning upMethods for cleaning up Use only non-sparking tools. All equipment used when handling the product must be grounded.

Large Spills: Use a non-combustible material like vermiculite, sand or earth to soak up the productand place into a container for later disposal. Dike far ahead of spill for later disposal.

Small Spills: Wipe up with absorbent material (e.g. cloth, fleece). Collect in a non-combustiblecontainer for prompt disposal.

Never return spills in original containers for re-use. Clean surface thoroughly to remove residualcontamination. Clean up in accordance with all applicable regulations.

J. T. Baker SOLUSORB® solvent adsorbent is recommended for spills of this product.

7777. . . . Handling and StorageHandling and StorageHandling and StorageHandling and StorageHandlingHandlingHandlingHandling DO NOT handle, store or open near an open flame, sources of heat or sources of ignition. Protect

material from direct sunlight. Take precautionary measures against static discharges. Wearappropriate personal protective equipment. Avoid breathing mist or vapor. Avoid contact witheyes, skin, and clothing. Do not taste or swallow. Use only with adequate ventilation. Washthoroughly after handling. See Section 8 of the MSDS for Personal Protective Equipment.

StorageStorageStorageStorage Keep away from food, drink and animal feedingstuffs. Keep out of the reach of children. Keepcontainer tightly closed in a cool, well-ventilated place. Ground container and transfer equipmentto eliminate static electric sparks. Comply with all national, state, and local codes pertaining to thestorage, handling, dispensing, and disposal of flammable liquids.

Canada Canada Canada Canada - - - - British ColumbiaBritish ColumbiaBritish ColumbiaBritish Columbia

8888. . . . Exposure Controls Exposure Controls Exposure Controls Exposure Controls / / / / Personal ProtectionPersonal ProtectionPersonal ProtectionPersonal ProtectionOccupational exposure limitsOccupational exposure limitsOccupational exposure limitsOccupational exposure limits

MaterialMaterialMaterialMaterial TypeTypeTypeType ValueValueValueValue

TOLUENE (108-88-3) 20.0000 ppmTWA

Canada Canada Canada Canada - - - - OntarioOntarioOntarioOntarioMaterialMaterialMaterialMaterial TypeTypeTypeType ValueValueValueValue

TOLUENE (108-88-3) 20.0000 ppmTWA

Canada Canada Canada Canada - - - - QuebecQuebecQuebecQuebecMaterialMaterialMaterialMaterial TypeTypeTypeType ValueValueValueValue

TOLUENE (108-88-3) 50.0000 ppmTWA188.0000 mg/m3

Engineering controlsEngineering controlsEngineering controlsEngineering controls Good general ventilation (typically 10 air changes per hour) should be used. Ventilation ratesshould be matched to conditions. If applicable, use process enclosures, local exhaust ventilation,or other engineering controls to maintain airborne levels below recommended exposure limits. Ifexposure limits have not been established, maintain airborne levels to an acceptable level.Explosion proof exhaust ventilation should be used.

Personal protective equipmentPersonal protective equipmentPersonal protective equipmentPersonal protective equipmentEye / face protectionEye / face protectionEye / face protectionEye / face protection Chemical goggles and face shield are recommended.Skin protectionSkin protectionSkin protectionSkin protection Wear appropriate chemical resistant clothing. Wear appropriate chemical resistant gloves.Respiratory protectionRespiratory protectionRespiratory protectionRespiratory protection Respirator type: Chemical respirator with organic vapor cartridge and full facepiece. Use a

positive-pressure air-supplied respirator if there is any potential for an uncontrolled release,exposure levels are not known, or any other circumstances where air-purifying respirators maynot provide adequate protection.

GeneralGeneralGeneralGeneral Provide eyewash station and safety shower.

9999. . . . Physical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesAppearanceAppearanceAppearanceAppearance Clear.


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ColorColorColorColor Colorless.

OdorOdorOdorOdor Aromatic. Sweet.


Physical statePhysical statePhysical statePhysical state Liquid.

FormFormFormForm Liquid.

pHpHpHpH Not available.

Melting pointMelting pointMelting pointMelting point -139 °F (-94.9 °C)

Freezing pointFreezing pointFreezing pointFreezing point -139 °F (-94.9 °C)

Boiling pointBoiling pointBoiling pointBoiling point 231.8 °F (110.6 °C)

Flash pointFlash pointFlash pointFlash point 39.2 °F (4 °C) Closed Cup

Evaporation rateEvaporation rateEvaporation rateEvaporation rate 2.24 BuAc


7.1 %


1.1 %

Vapor pressureVapor pressureVapor pressureVapor pressure 3.786 kPa at 25°C

Vapor densityVapor densityVapor densityVapor density 3.1



Solubility (water)Solubility (water)Solubility (water)Solubility (water) 0.7 g/l at 74°F


2.73

Auto-ignition temperatureAuto-ignition temperatureAuto-ignition temperatureAuto-ignition temperature 896 °F (480 °C)

Percent volatilePercent volatilePercent volatilePercent volatile 100 %


Molecular formulaMolecular formulaMolecular formulaMolecular formula C7-H8

10101010. . . . Chemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical stabilityChemical stabilityChemical stabilityChemical stability Stable under normal temperature conditions.Conditions to avoidConditions to avoidConditions to avoidConditions to avoid Heat, flames and sparks.Incompatible materialsIncompatible materialsIncompatible materialsIncompatible materials Strong oxidizing agents. Chlorine.Hazardous decompositionHazardous decompositionHazardous decompositionHazardous decompositionproductsproductsproductsproducts

At thermal decomposition temperatures, carbon monoxide and carbon dioxide.





ProductProductProductProduct Test ResultsTest ResultsTest ResultsTest ResultsAcute Dermal LD50 Rabbit: 12124 mg/kgTOLUENE (108-88-3)

Acute Inhalation LC50 Rat: 8000 ppm 4.00 Hours


Acute effectsAcute effectsAcute effectsAcute effects Harmful if inhaled or absorbed through skin. Harmful or fatal if swallowed.


Local effectsLocal effectsLocal effectsLocal effects Irritating to eyes, respiratory system and skin. High vapor concentrations may cause drowsinessand irritation of the eyes or respiratory tract.


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Chronic effectsChronic effectsChronic effectsChronic effects Toluene: Concentrated, prolonged or deliberate inhalation may cause brain and nervous systemdamage. Prolonged and repeated exposure of pregnant animals (> 1500 ppm) have beenreported to cause adverse fetal developmental effects. Frequent or prolonged contact may defatand dry the skin, leading to discomfort and dermatitis.


IARC Monographs. Overall Evaluation of CarcinogenicityIARC Monographs. Overall Evaluation of CarcinogenicityIARC Monographs. Overall Evaluation of CarcinogenicityIARC Monographs. Overall Evaluation of CarcinogenicityTOLUENE (CAS 108-88-3) 3 Not classifiable as to carcinogenicity to humans.

Neurological effectsNeurological effectsNeurological effectsNeurological effects High vapor/aerosol concentrations (attainable only at elevated temperatures) may cause centralnervous system effects such as dizziness, drowsiness or headaches. Central and/or peripheralnervous system damage.


Reproductive effectsReproductive effectsReproductive effectsReproductive effects Possible risk of harm to the unborn child.

TeratogenicityTeratogenicityTeratogenicityTeratogenicity Components in this product have been shown to cause birth defects and reproductive disorders inlaboratory animals.


Irritation. Upper respiratory tract irritation. Drowsiness and dizziness. Birth defects.





EC50 Water flea (Daphnia magna): 5.46 mg/l 48.00 hoursTOLUENE (108-88-3)LC50 Coho salmon,silver salmon (Oncorhynchus kisutch): 5.5mg/l 96.00 hoursLC50 Fathead minnow (Pimephales promelas): 12.6 mg/l 96.00hours

EcotoxicityEcotoxicityEcotoxicityEcotoxicity Toxic to aquatic life.

Environmental effectsEnvironmental effectsEnvironmental effectsEnvironmental effects Toxic to aquatic organisms. Bioaccumulation is unlikely to be significant because of the low watersolubility of this product. An environmental hazard cannot be excluded in the event ofunprofessional handling or disposal.


Expected to be readily biodegradable.

Partition coefficientPartition coefficientPartition coefficientPartition coefficient 2.73



Waste from residues / unusedWaste from residues / unusedWaste from residues / unusedWaste from residues / unusedproductsproductsproductsproducts

Dispose of in accordance with local regulations.

Contaminated packagingContaminated packagingContaminated packagingContaminated packaging Since emptied containers retain product residue, follow label warnings even after container isemptied. Residual vapors may explode on ignition; do not cut, drill, grind, or weld on or near thiscontainer. Offer rinsed packaging material to local recycling facilities.

14141414. . . . Transport InformationTransport InformationTransport InformationTransport InformationTDGTDGTDGTDG

TOLUENEProper shipping nameProper shipping nameProper shipping nameProper shipping name3Hazard classHazard classHazard classHazard classUN1294UN numberUN numberUN numberUN numberIIPacking groupPacking groupPacking groupPacking group


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TDGTDGTDGTDG

15151515. . . . Regulatory InformationRegulatory InformationRegulatory InformationRegulatory InformationCanadian regulationsCanadian regulationsCanadian regulationsCanadian regulations This product has been classified in accordance with the hazard criteria of the CPR and the MSDS

contains all the information required by the CPR.WHMIS statusWHMIS statusWHMIS statusWHMIS status ControlledWHMIS classificationWHMIS classificationWHMIS classificationWHMIS classification B2 - Flammable/Combustible

D2A - Other Toxic Effects-VERY TOXICD2B - Other Toxic Effects-TOXIC

WHMIS labelingWHMIS labelingWHMIS labelingWHMIS labeling






(PICCS)YesUnited States & Puerto Rico Toxic Substances Control Act (TSCA) Inventory


Saf-T-DataSaf-T-DataSaf-T-DataSaf-T-Data Health: 2 - Moderate (Life)Flammability: 3 - Severe (Flammable)Reactivity: 1 - SlightContact: 2 - Moderate (Life)Lab Protective Equip: DB - GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPERGLOVES; CLASS B EXTINGUISHERStorage Color Code: R - Red (Flammable)




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Issue dateIssue dateIssue dateIssue date 08-30-2011This data sheet containsThis data sheet containsThis data sheet containsThis data sheet containschanges from the previouschanges from the previouschanges from the previouschanges from the previousversion in section(s):version in section(s):version in section(s):version in section(s):

Exposure Controls / Personal Protection: Respiratory protection


MSDS CANADA

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SAFETY DATA SHEET




Page 1 of 19




Product name Iron(III) chloride anhydrous for synthesis






CAS-No. 7705-08-0








India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6

SAFETY DATA SHEET





Page 2 of 19


number











2.2 Label elements


Hazard pictograms

Signal word

Danger

Hazard statements







SAFETY DATA SHEET





Page 3 of 19

Prevention



Response






Hazard pictograms

Signal word

Danger

Hazard statements










Contains: iron(III) chloride, chromium(III) chloride, nickel(II) chloride

CAS-No. 7705-08-0

2.3 Other hazards

None known.

SAFETY DATA SHEET





Page 4 of 19


3.1 Substance

Formula FeCl₃ Cl₃Fe (Hill)

EC-No. 231-729-4





iron(III) chloride (>= 80 % - <= 100 % )

7705-08-0 *)





zinc chloride (< 0.25 % )


7646-85-7 *)


Skin corrosion, Category 1B, H314



M-Factor: 1





3.2 Mixture

Not applicable

SAFETY DATA SHEET





Page 5 of 19







contact lenses.


physician.


Nausea, Vomiting



kidneys.

Irritation and corrosion, Allergic reactions








environment.


Water, Foam

SAFETY DATA SHEET





Page 6 of 19


Not combustible.

May not get in touch with:

Water

Caution! in contact with water product releases:

hydrochloric acid








Further information







expert.






SAFETY DATA SHEET





Page 7 of 19



of dusts.






Keep workplace dry. Do not allow product to come into contact with water.


Hygiene measures






Storage conditions







SAFETY DATA SHEET





Page 8 of 19






See section 7.1.





Eye/face protection


Hand protection

full contact:




splash contact:









SAFETY DATA SHEET





Page 9 of 19






protective clothing



Recommended Filter type: Filter B-(P2)








Form powder

Colour green

to

black

Odour stinging


pH 1

at 200 g/l

20 °C

SAFETY DATA SHEET





Page 10 of 19


(decomposition)








at 20 °C


Density 2.89 g/cm3

at 25 °C



at 20 °C

Hydrolysis


octanol/water




SAFETY DATA SHEET





Page 11 of 19

Viscosity, dynamic Not applicable


Oxidizing properties Oxidizing potential

9.2 Other data

Sublimation point 304 °C

at 1,000 hPa



Viscosity, kinematic Not applicable



10.1 Reactivity

See section 10.3


sublimable

sensitive to moisture



Alkali metals, Ethylene oxide


ALLYL CHLORIDE

SAFETY DATA SHEET





Page 12 of 19

Aluminium, with, Heat

Generates dangerous gases or fumes in contact with:

Water



Exposure to moisture


Copper, Light metals

Metals





Acute oral toxicity

LD50 Rat: 316 mg/kg

(RTECS)

Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and

gastrointestinal tract., Nausea, Vomiting




LD50 Dermal Rat: > 2,000 mg/kg

(External MSDS)

SAFETY DATA SHEET





Page 13 of 19

Skin irritation

Rabbit

Result: irritating

(IUCLID)


Eye irritation

Rabbit




Sensitisation

May cause an allergic skin reaction.




Mouse

Result: negative

(External MSDS)


Ames test

Result: negative



Result: negative


Carcinogenicity




SAFETY DATA SHEET





Page 14 of 19

Teratogenicity






Repeated dose toxicity

Rat

male

Oral

98 d

daily

NOAEL: 277 mg/kg


Subchronic toxicity

Aspiration hazard



Decomposition of the substance with tissue moisture.



kidneys.




12.1 Toxicity

Toxicity to fish

LC50 Lepomis macrochirus (Bluegill sunfish): 20.3 mg/l; 96 h

(External MSDS)

SAFETY DATA SHEET





Page 15 of 19


Immobilization EC50 Daphnia magna (Water flea): 9.6 mg/l; 48 h


Toxicity to algae

ErC50 Pseudokirchneriella subcapitata (green algae): 6.9 mg/l; 72 h





NOEC Pimephales promelas (fathead minnow): 0.33 mg/l; 33 d

(External MSDS)


NOEC Daphnia magna (Water flea): 0.7 mg/l; 21 d

(External MSDS)











SAFETY DATA SHEET





Page 16 of 19





the product itself.






14.2 Proper shipping name FERRIC CHLORIDE, ANHYDROUS

14.3 Class 8




user

yes



Not relevant




14.3 Class 8



SAFETY DATA SHEET





Page 17 of 19


user

no




14.3 Class 8




user

yes

EmS F-A S-B


Not relevant




Storage class 8B



SAFETY DATA SHEET





Page 18 of 19











Training advice


Labelling

Hazard pictograms

Signal word

Danger

Hazard statements







SAFETY DATA SHEET





Page 19 of 19

Prevention


Response





Contains: iron(III) chloride, chromium(III) chloride, nickel(II) chloride






1111. . . . Product and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationProduct and Company IdentificationMaterial nameMaterial nameMaterial nameMaterial name ZINC CHLORIDEZINC CHLORIDEZINC CHLORIDEZINC CHLORIDEVersion #Version #Version #Version # 02Revision dateRevision dateRevision dateRevision date 08-30-2011CAS #CAS #CAS #CAS # 7646-85-7Product CodesProduct CodesProduct CodesProduct Codes J.T.Baker: 4320, 4321, 4322, 4326J.T.Baker: 4320, 4321, 4322, 4326J.T.Baker: 4320, 4321, 4322, 4326J.T.Baker: 4320, 4321, 4322, 4326

Macron: 8772, 8780Macron: 8772, 8780Macron: 8772, 8780Macron: 8772, 8780Synonym(s)Synonym(s)Synonym(s)Synonym(s) Zinc Chloride, Zinc Dichloride, Zinc Butter





Suite #200


Corrosive. Causes severe skin and eye burns. Causes digestive tract burns. Harmful if inhaled orswallowed. Dust or vapor extremely irritating to the eyes and respiratory tract.

OSHA regulatory statusOSHA regulatory statusOSHA regulatory statusOSHA regulatory status This product is considered hazardous under 29 CFR 1910.1200 (Hazard Communication).

Potential health effectsPotential health effectsPotential health effectsPotential health effectsRoutes of exposureRoutes of exposureRoutes of exposureRoutes of exposure Ingestion. Inhalation. Skin contact. Eye contact.EyesEyesEyesEyes Corrosive. Causes severe eye burns. Dust or splashes from the mixture may cause permanent

eye damage.SkinSkinSkinSkin Corrosive. Causes severe skin burns.InhalationInhalationInhalationInhalation Harmful if inhaled. Corrosive. May cause damage to mucous membranes in nose, throat, lungs

and bronchial system.IngestionIngestionIngestionIngestion Harmful if swallowed. Corrosive. Ingestion may produce burns to the lips, oral cavity, upper

airway, esophagus and possibly the digestive tract.Target organsTarget organsTarget organsTarget organs Eyes. Skin. Lungs. Respiratory system. Liver.Chronic effectsChronic effectsChronic effectsChronic effects Corrosive. Prolonged contact causes serious tissue damage. May cause liver damage based on

animal data.Potential environmental effectsPotential environmental effectsPotential environmental effectsPotential environmental effects Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.



7646-85-7 97 - 100ZINC CHLORIDE


Eye contactEye contactEye contactEye contact Immediately flush with plenty of water for at least 15 minutes. If easy to do, remove contactlenses. Call a physician or poison control center immediately. In case of irritation from airborneexposure, move to fresh air. Get medical attention immediately.

Material name: ZINC CHLORIDEMSDS ID: Z2280 Version #: 02 Revision date: 08-30-2011

MSDS US COV

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Skin contactSkin contactSkin contactSkin contact Immediately flush with plenty of water for at least 15 minutes while removing contaminatedclothing and shoes. Call a physician or poison control center immediately. Wash clothingseparately before reuse. Destroy or thoroughly clean contaminated shoes.

InhalationInhalationInhalationInhalation Move to fresh air. If breathing stops, provide artificial respiration. If breathing is difficult, giveoxygen. Call a physician or poison control center immediately.

IngestionIngestionIngestionIngestion Call a physician or poison control center immediately. Do not induce vomiting. If vomiting occurs,the head should be kept low so that stomach vomit doesn't enter the lungs.

Notes to physicianNotes to physicianNotes to physicianNotes to physician Keep victim under observation. Treat symptomatically.General adviceGeneral adviceGeneral adviceGeneral advice In the case of accident or if you feel unwell, seek medical advice immediately (show the label

where possible). Show this safety data sheet to the doctor in attendance. Ensure that medicalpersonnel are aware of the material(s) involved, and take precautions to protect themselves.

5555. . . . Fire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFire Fighting MeasuresFlammable propertiesFlammable propertiesFlammable propertiesFlammable properties The product is not flammable. No unusual fire or explosion hazards noted.


Water spray. Carbon dioxide (CO2). Dry chemical powder. Foam.


None known.


Fire may produce irritating, corrosive and/or toxic gases.

Protective equipment andProtective equipment andProtective equipment andProtective equipment andprecautions for firefightersprecautions for firefightersprecautions for firefightersprecautions for firefighters

Use water spray to cool unopened containers. Self-contained breathing apparatus and fullprotective clothing must be worn in case of fire. Cool containers exposed to flames with water untilwell after the fire is out.


Wear full protective clothing, including helmet, self-contained positive pressure or pressuredemand breathing apparatus, protective clothing and face mask. Wear self-contained breathingapparatus with a full facepiece operated in the positive pressure demand mode when fightingfires.

Specific methodsSpecific methodsSpecific methodsSpecific methods In the event of fire and/or explosion do not breathe fumes.

6666. . . . Accidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresAccidental Release MeasuresPersonal precautionsPersonal precautionsPersonal precautionsPersonal precautions Keep unnecessary personnel away. Wear appropriate protective equipment and clothing during

clean-up. Keep upwind. Keep out of low areas. Ventilate closed spaces before entering them.Local authorities should be advised if significant spillages cannot be contained.

Environmental precautionsEnvironmental precautionsEnvironmental precautionsEnvironmental precautions Do not allow to enter drains, sewers or watercourses. Prevent further leakage or spillage if safe todo so.

Methods for containmentMethods for containmentMethods for containmentMethods for containment Prevent entry into waterways, sewers, basements or confined areas. Stop leak if you can do sowithout risk. Dike the spilled material, where this is possible.


Large Spills: Sweep up or vacuum up spillage and collect in suitable container for disposal.

Small Spills: Sweep up and place in a clearly labeled container for chemical waste. Clean surfacethoroughly to remove residual contamination.

Never return spills in original containers for re-use. Clean up in accordance with all applicableregulations. Neutralize spill area and washings with soda ash or lime. Collect in anon-combustible container for prompt disposal.

7777. . . . Handling and StorageHandling and StorageHandling and StorageHandling and StorageHandlingHandlingHandlingHandling Wear appropriate personal protective equipment. Do not breathe dust or vapor. Do not get in

eyes, on skin, on clothing. Do not taste or swallow. Wash thoroughly after handling. Do not eat,drink or smoke when using the product. See Section 8 of the MSDS for Personal ProtectiveEquipment.


MSDS US COV

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StorageStorageStorageStorage Keep tightly closed in a dry, cool and well-ventilated place.

ACGIHACGIHACGIHACGIH

8888. . . . Exposure Controls Exposure Controls Exposure Controls Exposure Controls / / / / Personal ProtectionPersonal ProtectionPersonal ProtectionPersonal Protection

MaterialMaterialMaterialMaterial TypeTypeTypeType ValueValueValueValue FormFormFormForm

ZINC CHLORIDE (7646-85-7) 2.0000 mg/m3 Fume.STEL1.0000 mg/m3 Fume.TWA

UUUU....SSSS. - . - . - . - OSHAOSHAOSHAOSHAOccupational exposure limitsOccupational exposure limitsOccupational exposure limitsOccupational exposure limits

MaterialMaterialMaterialMaterial TypeTypeTypeType ValueValueValueValue FormFormFormForm

ZINC CHLORIDE (7646-85-7) 1.0000 mg/m3 Fume.PEL

Engineering controlsEngineering controlsEngineering controlsEngineering controls Good general ventilation (typically 10 air changes per hour) should be used. Ventilation ratesshould be matched to conditions. If applicable, use process enclosures, local exhaust ventilation,or other engineering controls to maintain airborne levels below recommended exposure limits. Ifexposure limits have not been established, maintain airborne levels to an acceptable level.

Personal protective equipmentPersonal protective equipmentPersonal protective equipmentPersonal protective equipmentEye / face protectionEye / face protectionEye / face protectionEye / face protection Wear safety glasses with side shields (or goggles) and a face shield.Skin protectionSkin protectionSkin protectionSkin protection Wear appropriate chemical resistant clothing. Wear appropriate chemical resistant gloves.Respiratory protectionRespiratory protectionRespiratory protectionRespiratory protection If engineering controls do not maintain airborne concentrations below recommended exposure




GeneralGeneralGeneralGeneral Wear chemical protective equipment that is specifically recommended by the manufacturer.Launder contaminated clothing before reuse.

9999. . . . Physical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesPhysical & Chemical PropertiesAppearanceAppearanceAppearanceAppearance Crystalline. Granular.

ColorColorColorColor White.




FormFormFormForm Crystalline. Granular.

pHpHpHpH 1 (6 M Solution)

Melting pointMelting pointMelting pointMelting point 554 °F (290 °C)

Freezing pointFreezing pointFreezing pointFreezing point 554 °F (290 °C)

Boiling pointBoiling pointBoiling pointBoiling point 1349.6 °F (732 °C)



Not available.


Not available.



Solubility (water)Solubility (water)Solubility (water)Solubility (water) 4350 g/l at 70°F


Not available


MSDS US COV

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Molecular formulaMolecular formulaMolecular formulaMolecular formula Cl2-Zn

10101010. . . . Chemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical Stability & Reactivity InformationChemical stabilityChemical stabilityChemical stabilityChemical stability Stable under normal temperature conditions.Conditions to avoidConditions to avoidConditions to avoidConditions to avoid Do not allow water to get into container because of reaction.Incompatible materialsIncompatible materialsIncompatible materialsIncompatible materials Strong oxidizing agents. Bases, alkalies (organic). Potassium. Moisture.Hazardous decompositionHazardous decompositionHazardous decompositionHazardous decompositionproductsproductsproductsproducts

Hydrogen chloride. Zinc oxide.





ProductProductProductProduct Test ResultsTest ResultsTest ResultsTest ResultsAcute Inhalation LC50 Rat: 1.975 mg/l 10.00 MinutesZINC CHLORIDE (7646-85-7)



Acute effectsAcute effectsAcute effectsAcute effects Harmful if inhaled or swallowed. Strongly corrosive. May cause deep tissue damage. Vapors arecorrosive. After some hours, injured persons may develop serious shortness of breath and lungedema.

Local effectsLocal effectsLocal effectsLocal effects Causes severe burns.

Chronic effectsChronic effectsChronic effectsChronic effects Corrosive. Prolonged contact causes serious tissue damage. May cause liver damage based onanimal data.


Skin corrosion/irritationSkin corrosion/irritationSkin corrosion/irritationSkin corrosion/irritation Corrosive to skin and eyes.



Neurological effectsNeurological effectsNeurological effectsNeurological effects No data available for this product.



Corrosive effects.

Further informationFurther informationFurther informationFurther information Danger of very serious irreversible effects. Symptoms may be delayed.




EC50 Water flea (Daphnia magna): 0.1 mg/l 48.00 hoursZINC CHLORIDE (7646-85-7)LC50 Inland silverside (Menidia beryllina): 0.03 mg/l 96.00hours

EcotoxicityEcotoxicityEcotoxicityEcotoxicity Expected to be very toxic to aquatic organisms. May cause long-term adverse effects in theenvironment. The product may affect the acidity (pH-factor) in water with risk of harmful effects toaquatic organisms.


The product is not readily biodegradable.


Not available


MSDS US COV

4 / 7



Contaminated packagingContaminated packagingContaminated packagingContaminated packaging Since emptied containers retain product residue, follow label warnings even after container isemptied. Offer rinsed packaging material to local recycling facilities.

14141414. . . . Transport InformationTransport InformationTransport InformationTransport InformationDOTDOTDOTDOT

Basic shipping requirements:Basic shipping requirements:Basic shipping requirements:Basic shipping requirements:UN2331UN numberUN numberUN numberUN numberZinc chloride, anhydrousProper shipping nameProper shipping nameProper shipping nameProper shipping name8Hazard classHazard classHazard classHazard classIIIPacking groupPacking groupPacking groupPacking group

Additional information:Additional information:Additional information:Additional information:IB8, IP3, T1, TP33Special provisionsSpecial provisionsSpecial provisionsSpecial provisions

Basic shipping requirements:Basic shipping requirements:Basic shipping requirements:Basic shipping requirements:8Labels requiredLabels requiredLabels requiredLabels required

Additional information:Additional information:Additional information:Additional information:NonePackaging exceptionsPackaging exceptionsPackaging exceptionsPackaging exceptions213Packaging non bulkPackaging non bulkPackaging non bulkPackaging non bulk240Packaging bulkPackaging bulkPackaging bulkPackaging bulk1000Reportable quantityReportable quantityReportable quantityReportable quantity154ERG numberERG numberERG numberERG number

IATAIATAIATAIATABasic shipping requirements:Basic shipping requirements:Basic shipping requirements:Basic shipping requirements:

2331UN numberUN numberUN numberUN numberZinc chloride, anhydrousProper shipping nameProper shipping nameProper shipping nameProper shipping name8Hazard classHazard classHazard classHazard classIIIPacking groupPacking groupPacking groupPacking group

Additional information:Additional information:Additional information:Additional information:8LERG codeERG codeERG codeERG code

IMDGIMDGIMDGIMDGBasic shipping requirements:Basic shipping requirements:Basic shipping requirements:Basic shipping requirements:

2331UN numberUN numberUN numberUN numberZINC CHLORIDE, ANHYDROUSProper shipping nameProper shipping nameProper shipping nameProper shipping name8Hazard classHazard classHazard classHazard classIIIPacking groupPacking groupPacking groupPacking group

DOTDOTDOTDOT IATAIATAIATAIATA IMDGIMDGIMDGIMDG


Standard, 29 CFR 1910.1200.All components are on the U.S. EPA TSCA Inventory List.


MSDS US COV

5 / 7

US EPCRA (SARA Title III) Section 313 - Toxic Chemical: De minimis concentrationUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: De minimis concentrationUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: De minimis concentrationUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: De minimis concentrationZINC CHLORIDE (CAS 7646-85-7) 1.0 % N982

US EPCRA (SARA Title III) Section 313 - Toxic Chemical: Listed substanceUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: Listed substanceUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: Listed substanceUS EPCRA (SARA Title III) Section 313 - Toxic Chemical: Listed substanceZINC CHLORIDE (CAS 7646-85-7) Listed. N982

CERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityCERCLA (Superfund) reportable quantityZINC CHLORIDE: 1000.0000


Delayed Hazard - YesFire Hazard - NoPressure Hazard - NoReactivity Hazard - No


Yes

Clean Water Act (CWA)Clean Water Act (CWA)Clean Water Act (CWA)Clean Water Act (CWA) Hazardous substancePriority pollutantToxic pollutant






(PICCS)YesUnited States & Puerto Rico Toxic Substances Control Act (TSCA) Inventory



US - New Jersey Community RTK (EHS Survey): Reportable thresholdUS - New Jersey Community RTK (EHS Survey): Reportable thresholdUS - New Jersey Community RTK (EHS Survey): Reportable thresholdUS - New Jersey Community RTK (EHS Survey): Reportable thresholdZINC CHLORIDE (CAS 7646-85-7) 500 LBS

US - Pennsylvania RTK - Hazardous Substances: Listed substanceUS - Pennsylvania RTK - Hazardous Substances: Listed substanceUS - Pennsylvania RTK - Hazardous Substances: Listed substanceUS - Pennsylvania RTK - Hazardous Substances: Listed substanceZINC CHLORIDE (CAS 7646-85-7) Listed.

Saf-T-DataSaf-T-DataSaf-T-DataSaf-T-Data Health: 3 - Severe (Life)Flammability: 0 - NoneReactivity: 1 - SlightContact: 3 - Severe (Corrosive)Lab Protective Equip: D - GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPERGLOVESStorage Color Code: W - White (Corrosive)


Corrosive. Causes severe skin and eye burns. Causes digestive tract burns. Harmful if inhaled orswallowed. Dust or vapor extremely irritating to the eyes and respiratory tract.


MSDS US COV

6 / 7

Label PrecautionsLabel PrecautionsLabel PrecautionsLabel Precautions Do not breathe dust. Do not get in eyes, on skin, or on clothing. Use only with adequateventilation. Keep container closed. Wash thoroughly after handling.

Label First AidLabel First AidLabel First AidLabel First Aid Immediately flush eyes with plenty of water for at least 15 minutes. Immediately flush skin withplenty of water. If gas/fume/vapor/dust/mist from the material is inhaled, remove the affectedperson immediately to fresh air. Get medical attention immediately. IF SWALLOWED:Immediately call a POISON CENTER or doctor/physician. Do not induce vomiting without advicefrom poison control center. If vomiting occurs, keep head low so that stomach content doesn't getinto the lungs. Do not use mouth-to-mouth method if victim ingested the substance.






MSDS US COV

7 / 7

Material Safety Data Sheet

1. PRODUCT AND COMPANY IDENTIFICATION

Product Name Calcium chloride dihydrate Cat No. BP510-100; BP510-250; BP510-500; C69-50; C69-500; C69-500LC; C70-

500; C79-3; C79-3LC; C79-500 Synonyms (Crystals/Powder/Granules/USP/FCC/EP/Certified ACS) Recommended Use Laboratory chemicals

2. HAZARDS IDENTIFICATION

Target Organs Eyes Potential Health Effects Acute Effects Principle Routes of Exposure Eyes Irritating to eyes. Skin May cause irritation. Inhalation May cause irritation of respiratory tract. May be harmful if inhaled. Ingestion May be harmful if swallowed. Ingestion may cause gastrointestinal irritation, nausea, vomiting

and diarrhea. Chronic Effects None known. See Section 11 for additional Toxicological information. Aggravated Medical Conditions No information available.

_____________________________________________________________________________________________

Page 1 / 7

Revision Number 1

Irritating to eyes. May cause skin and respiratory tract irritation. Hygroscopic.

Creation Date 14-Aug-2009 Revision Date 22-Sep-2009

CompanyFisher ScientificOne Reagent LaneFair Lawn, NJ 07410Tel: (201) 796-7100

WARNING!

Emergency Telephone NumberCHEMTREC®, Inside the USA: 800-424-9300CHEMTREC®, Outside the USA: 703-527-3887

Emergency Overview

odor odorlessAppearance Beige - White Physical State Solid

_____________________________________________________________________________________________

3. COMPOSITION/INFORMATION ON INGREDIENTS

Haz/Non-haz

Component CAS-No Weight %Calcium chloride, dihydrate 10035-04-8 >95

Calcium chloride 10043-52-4 -


Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Obtain

medical attention. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Get medical attention

immediately if symptoms occur.. Inhalation Move to fresh air. If breathing is difficult, give oxygen. Get medical attention immediately if

symptoms occur. Ingestion Do not induce vomiting. Obtain medical attention. Notes to Physician Treat symptomatically.

5. FIRE-FIGHTING MEASURES

Flash Point No information available. Method No information available. Autoignition Temperature No information available.Explosion Limits Upper No data available Lower No data available Suitable Extinguishing Media Substance is nonflammable; use agent most appropriate to

extinguish surrounding fire.. Unsuitable Extinguishing Media No information available. Hazardous Combustion Products No information available. Sensitivity to mechanical impact No information available. Sensitivity to static discharge No information available. Specific Hazards Arising from the ChemicalNon-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Protective Equipment and Precautions for FirefightersAs in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.


Personal Precautions Ensure adequate ventilation. Use personal protective equipment. Avoid dust formation.

_____________________________________________________________________________________________

Page 2 / 7

Flammability 0 Instability 1 Physical hazards N/A

Thermo Fisher Scientific - Calcium chloride dihydrate

NFPA

Revision Date 22-Sep-2009

Health 2

_____________________________________________________________________________________________ Environmental Precautions Should not be released into the environment. Methods for Containment and Clean Up

Sweep up or vacuum up spillage and collect in suitable container for disposal. Avoid dust formation.


Handling Wear personal protective equipment. Ensure adequate ventilation. Do not get in eyes, on skin,

or on clothing. Avoid ingestion and inhalation. Avoid dust formation. Storage Keep containers tightly closed in a dry, cool and well-ventilated place.

8. EXPOSURE CONTROLS / PERSONAL PROTECTION

Engineering Measures Ensure that eyewash stations and safety showers are close to the workstation location. Ensure

adequate ventilation, especially in confined areas. Exposure Guidelines

Component Quebec Mexico OEL (TWA) Ontario TWAEVCalcium chloride TWA: 5 mg/m3

NIOSH IDLH: Immediately Dangerous to Life or Health Personal Protective Equipment Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's

eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure. Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN

149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.


Physical State SolidAppearance Beige - Whiteodor odorlessOdor Threshold No information available.pH 4.5-6.5 100 g/l aq. sol. Vapor Pressure No information available.Vapor Density No information available.Viscosity No information available.Boiling Point/Range No information available.Melting Point/Range 175°C / 347°FDecomposition temperature No information available.Flash Point No information available.Evaporation Rate No information available.Specific Gravity 0.830Solubility Soluble in waterlog Pow No data availableMolecular Weight 147.02Molecular Formula Ca Cl2 . 2 H2 O

_____________________________________________________________________________________________

Page 3 / 7

Revision Date 22-Sep-2009Thermo Fisher Scientific - Calcium chloride dihydrate

_____________________________________________________________________________________________


Stability Hygroscopic. Conditions to Avoid Incompatible products. Excess heat. Avoid dust formation.

Exposure to moist air or water. Incompatible Materials Strong oxidizing agents Hazardous Decomposition Products Hydrogen chloride gas Hazardous Polymerization Hazardous polymerization does not occur. Hazardous Reactions . None under normal processing..


Acute Toxicity

Component Information

Component LD50 Oral LD50 Dermal LC50 InhalationCalcium chloride 1000 mg/kg ( Rat ) 2630 mg/kg ( Rat ) Not listed

Irritation Irritating to eyes Toxicologically Synergistic Products


Chronic Toxicity Carcinogenicity There are no known carcinogenic chemicals in this product

Sensitization No information available. Mutagenic Effects No information available. Reproductive Effects No information available. Developmental Effects No information available. Teratogenicity No information available. Other Adverse Effects See actual entry in RTECS for complete information. Endocrine Disruptor Information No information available


_____________________________________________________________________________________________

Page 4 / 7

Revision Date 22-Sep-2009Thermo Fisher Scientific - Calcium chloride dihydrate

_____________________________________________________________________________________________

12. ECOLOGICAL INFORMATIONEcotoxicityDo not empty into drains.

Component Freshwater Algae Freshwater Fish Microtox Water FleaCalcium chloride, dihydrate Not listed Lepomis macrochirus: LC50:

10650 mg/L/96hNot listed EC50: 3005 mg/L/48h

Calcium chloride Not listed Lepomis macrochirus: LC50: 10650 mg/L/96h

Not listed EC50: 52 mg/L/48h

Persistence and Degradability No information available Bioaccumulation/ Accumulation No information available Mobility .

Component log PowCalcium chloride, dihydrate 0.05


Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a

hazardous waste. Chemical waste generators must also consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification.


DOT Not regulated

TDG Not regulated

IATA Not regulated

IMDG/IMO Not regulated


International Inventories

Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS CHINA KECL Calcium chloride, dihydrate - - - - - X X X X -

Calcium chloride X X - 233-140-8

- X X X X KE-04496

X Legend:

_____________________________________________________________________________________________

Page 5 / 7

Thermo Fisher Scientific - Calcium chloride dihydrate Revision Date 22-Sep-2009

_____________________________________________________________________________________________ X - Listed E - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA. F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA. N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designated polymer made with any free-radical initiator regardless of the amount used. P - Indicates a commenced PMN substance R - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA. S - Indicates a substance that is identified in a proposed or final Significant New Use Rule T - Indicates a substance that is the subject of a Section 4 test rule under TSCA. XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data Base Production and Site Reports (40 CFR 710(B). Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater. Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactants that comprises one of the eligibility criteria for the exemption rule.

U.S. Federal Regulations TSCA 12(b) Not applicable SARA 313Not applicable

SARA 311/312 Hazardous Categorization Acute Health Hazard Yes Chronic Health Hazard No Fire Hazard No Sudden Release of Pressure Hazard No Reactive Hazard No Clean Water Act Not applicable

Clean Air Act Not applicable OSHA Not applicable CERCLA Not Applicable California Proposition 65 This product does not contain any Proposition 65 chemicals.

State Right-to-KnowNot applicable U.S. Department of Transportation Reportable Quantity (RQ): NDOT Marine Pollutant NDOT Severe Marine Pollutant N U.S. Department of Homeland Security This product does not contain any DHS chemicals. Other International Regulations

_____________________________________________________________________________________________

Page 6 / 7


_____________________________________________________________________________________________ Mexico - Grade No information available Canada This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all the information required by the CPR. WHMIS Hazard ClassD2B Toxic materials


Prepared By Regulatory Affairs Thermo Fisher Scientific

Tel: (412) 490-8929 Creation Date 14-Aug-2009 Print Date 22-Sep-2009 Revision Summary "***", and red text indicates revision Disclaimer The information provided on this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered as a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other material or in any process, unless specified in the text.

End of MSDS

_____________________________________________________________________________________________

Page 7 / 7





Page 1 of 10




Product name Hydrochloric acid c(HCl) = 0.357 mol/l (1/2.8 N) Titripur®

REACH Registration Number This product is a mixture. REACH Registration Number see section 3.








India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6


number







Classification (67/548/EEC or 1999/45/EC)In accordance with EC directives or respective national laws, the

product does not need to be classified nor labelled.

2.2 Label elements


Hazard pictograms

Signal wordWarning

Hazard statementsH290 May be corrosive to metals.

2.3 Other hazards

None known.

SAFETY DATA SHEET





Page 2 of 10


Chemical nature Aqueous solution

3.1 Substance

Not applicable

3.2 Mixture


Chemical Name (Concentration) CAS-No. Registration number Classification

Hydrochloric Acid (>= 1 % - < 5 % ) Substance does not meet the criteria for PBT or vPvB according to Regulation (EC) No 1907/2006, Annex XIII.

7647-01-0 *)


Skin corrosion, Category 1B, H314

Specific target organ toxicity - single exposure, Category 3, H335





Hazardous components (1999/45/EC)

Chemical Name (Concentration) CAS-No. Classification

Hydrochloric Acid (>= 1 % - < 5 % ) 7647-01-0 C, Corrosive; R34

Xi, Irritant; R37

For the full text of the R-phrases mentioned in this Section, see Section 16.





shower.

After eye contact: rinse out with plenty of water. Call in ophthalmologist.



irritant effects






environment.

SAFETY DATA SHEET





Page 3 of 10



Not combustible.





Special protective equipment for firefightersStay in danger area only with self-contained breathing apparatus. Prevent skin contact by






Advice for non-emergency personnel: Avoid substance contact. Do not breathe vapours,

aerosols. Evacuate the danger area, observe emergency procedures, consult an expert.







Take up with liquid-absorbent and neutralising material (e.g. Chemizorb® H⁺, Merck Art. No.

101595). Dispose of properly. Clean up affected area.






Cannot be stored indefinitely.

Hygiene measuresChange contaminated clothing. Preventive skin protection recommended. Wash hands after

working with substance.


Requirements for storage areas and containersNo metal containers.

Storage conditionsTightly closed.


SAFETY DATA SHEET





Page 4 of 10





Hydrochloric Acid (7647-01-0)IN OEL Ceiling Limit Value: 5 ppm

7 mg/m³





See section 7.1.






Hand protection

full contact:




splash contact:













Other protective equipmentprotective clothing

Respiratory protectionrequired when vapours/aerosols are generated.

Recommended Filter type: filter E-(P2)




SAFETY DATA SHEET





Page 5 of 10





Form liquid

Colour colourless

Odour odourless


pH ca. 1.2

at 20 °C

Melting point No information available.









Density ca.1.01 g/cm3

at 20 °C



soluble


octanol/water






SAFETY DATA SHEET





Page 6 of 10


9.2 Other data




10.1 Reactivity

See section 10.3





Metals


The generally known reaction partners of water.




Metals, metal alloys





Mixture

Acute oral toxicityThis information is not available.



Skin irritation


Eye irritation




SAFETY DATA SHEET





Page 7 of 10




Specific target organ toxicity - single exposureThe substance or mixture is not classified as specific target organ toxicant, single exposure.

Specific target organ toxicity - repeated exposureThe substance or mixture is not classified as specific target organ toxicant, repeated exposure.

Aspiration hazardBased on available data the classification criteria are not met.




Components

Hydrochloric Acid

Skin irritationRabbit

Result: Corrosive


Eye irritationRabbit



SensitisationMaximisation Test (GPMT) Guinea pig




Mixture

12.1 Toxicity









Substance(s) in the mixture do(es) not meet the criteria for PBT or vPvB according to Regulation

(EC) No 1907/2006, Annex XIII, or a PBT/vPvB assessment was not conducted.


SAFETY DATA SHEET





Page 8 of 10

Additional ecological informationNo ecological problems are to be expected when the product is handled and used with due care

and attention.

Components

Hydrochloric Acid





the product itself.






14.2 Proper shipping name HYDROCHLORIC ACID

14.3 Class 8




user

yes



Not relevant




14.3 Class 8




user

no




14.3 Class 8



SAFETY DATA SHEET





Page 9 of 10


user

yes

EmS F-A S-B


Not relevant



EU regulations

Occupational restrictions Take note of Dir 94/33/EC on the protection of young people at

work.


Storage class 8B







H335 May cause respiratory irritation.

Full text of R-phrases referred to under sections 2 and 3

R34 Causes burns.

R37 Irritating to respiratory system.

Training advice


Labelling

Hazard pictograms

Signal wordWarning

Hazard statementsH290 May be corrosive to metals.



laws.

SAFETY DATA SHEET





Page 10 of 10




SAFETY DATA SHEET




Page 1 of 17




Product name Sodium hydroxide pellets for analysis (max. 0.02% K) EMSURE®

ACS,Reag. Ph Eur,ISO






CAS-No. 1310-73-2








India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6


number


SAFETY DATA SHEET




Ph Eur,ISO


Page 2 of 17







2.2 Label elements


Hazard pictograms

Signal word

Danger

Hazard statements




Prevention


Response





SAFETY DATA SHEET




Ph Eur,ISO


Page 3 of 17


Hazard pictograms

Signal word

Danger

Hazard statements








CAS-No. 1310-73-2

2.3 Other hazards

None known.


3.1 Substance

Formula NaOH HNaO (Hill)

EC-No. 215-185-5





sodium hydroxide (<= 100 % )


1310-73-2 *)

SAFETY DATA SHEET




Ph Eur,ISO


Page 4 of 17







3.2 Mixture

Not applicable



General advice






contact lenses.




Risk of blindness!

Irritation and corrosion, Cough, Shortness of breath, collapse, death



SAFETY DATA SHEET




Ph Eur,ISO


Page 5 of 17





environment.




Not combustible.






Further information







expert.





SAFETY DATA SHEET




Ph Eur,ISO


Page 6 of 17




of dusts.







Hygiene measures





No aluminium, tin, or zinc containers.


Storage conditions







SAFETY DATA SHEET




Ph Eur,ISO


Page 7 of 17

sodium hydroxide (1310-73-2)

IN OEL Ceiling Limit Value: 2 mg/m³





See section 7.1.





Eye/face protection


Hand protection

full contact:




splash contact:









SAFETY DATA SHEET




Ph Eur,ISO


Page 8 of 17






protective clothing




substances








Form solid

Colour white

Odour odourless


pH ca. > 14

at 100 g/l

20 °C

SAFETY DATA SHEET




Ph Eur,ISO


Page 9 of 17

Melting point/range 319 - 322 °C

Boiling point/boiling range 1,390 °C

at 1,013 hPa







Not applicable


Density 2.13 g/cm3

at 20 °C


Water solubility 1,090 g/l

at 20 °C


octanol/water




SAFETY DATA SHEET




Ph Eur,ISO


Page 10 of 17




9.2 Other data




10.1 Reactivity

See section 10.3


hygroscopic



Acetone, Chlorine, Ethylene oxide, Fluorine, Hydrogen halides, Hydrazine hydrate,

hydroxylamine, Acid anhydrides, Acrolein, Acid chlorides, Acids, sulphuric acid, Chloroform,

Water, hydrogen peroxide, anhydrides, EPICHLOROHYDRIN, phosphides, halogen-halogen

compounds, trichloroethene, ALLYL ALCOHOL

can decompose violently in contact with:

Organic Substances, hydrogen sulphide


powdered aluminium, Ammonium salts, persulfates, Sodium borohydride, phosphorus, Oxides of

phosphorus, Halogenated hydrocarbon, Light metals, Metals

Risk of explosion/exothermic reaction with:

SAFETY DATA SHEET




Ph Eur,ISO


Page 11 of 17

Bromine, Calcium, in powder form, furfuryl alcohol, Nitromethane, Peroxides, organic nitro

compounds, Nitriles, Acrylic monomers, SILVER NITRATE

Chloroform, with, Acetone

Nitrobenzene, with, Methanol

Nitrobenzene, with, salts

magnesium, Zinc, and, Tin, (in the presence of atmospheric oxygen and/or moisture)


Moisture.


Aluminium, brass, Metals, metal alloys, Zinc, Tin





Acute oral toxicity




Symptoms: burns of mucous membranes, Cough, Shortness of breath, Possible damages:,

damage of respiratory tract



SAFETY DATA SHEET




Ph Eur,ISO


Page 12 of 17

Skin irritation

Rabbit


(External MSDS)


Eye irritation

Rabbit


(ECHA)


Risk of blindness!

Sensitisation

Patch test: human

Result: negative

(ECHA)




Result: negative

(Lit.)

Ames test

Result: negative

(IUCLID)

Carcinogenicity




SAFETY DATA SHEET




Ph Eur,ISO


Page 13 of 17

Teratogenicity






Aspiration hazard



Systemic effects:

collapse, death




12.1 Toxicity

Toxicity to fish


(External MSDS)


EC50 Ceriodaphnia (water flea): 40.4 mg/l; 48 h

(ECHA)


EC50 Photobacterium phosphoreum: 22 mg/l; 15 min

(External MSDS)


Biodegradability


substances.


SAFETY DATA SHEET




Ph Eur,ISO


Page 14 of 17








Harmful effect due to pH shift.

Forms corrosive mixtures with water even if diluted.

Neutralisation possible in waste water treatment plants.


SAFETY DATA SHEET




Ph Eur,ISO


Page 15 of 17





the product itself.







14.3 Class 8




user

yes



Not relevant




14.3 Class 8



SAFETY DATA SHEET




Ph Eur,ISO


Page 16 of 17


user

no




14.3 Class 8




user

yes

EmS F-A S-B


Not relevant




Storage class 8B







Training advice

SAFETY DATA SHEET




Ph Eur,ISO


Page 17 of 17


Labelling

Hazard pictograms

Signal word

Danger

Hazard statements




Prevention


Response









Date of issue: 27.06.2014 Version: 1.0

Company: EMD Millipore Corporation | 290 Concord Road, Billerica, MA 01821, United States of America | General Inquiries: +1-978-715-4321 | Monday to Friday, 9:00 AM to 4:00 PM Eastern Time (GMT-5)

Responsible Department:

Emergency telephone number:

800-424-9300 CHEMTREC (USA) +1-703-527-3887 CHEMTREC (International) 24 Hours/day; 7 Days/week

Catalogue No.: 420311

Product name: Kanamycin Sulfate, Streptomyces kanamyceticus

REACH Registration Number:

A registration number is not available for this substance as the substance or its use are exempted from registration according to Article 2 REACH Regulation (EC) No 1907/2006, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

This item is not a hazardous substance and does not contain hazardous ingredients, substances with European Community workplace exposure limits or substances of very high concern (SVHC) above their respective disclosure limits. Hence a safety data sheet is not required according to Regulation (EC) No. 1907/2006 (REACH) and also not available in this case. The information has been generated by EDP and bears no signature.

p. 1

1 3 0

He a lt h

Fire

Re a c t iv it y


3

1

0

Material Safety Data SheetPhenylmethylsulfonyl fluoride MSDS


Product Name: Phenylmethylsulfonyl fluoride

Catalog Codes: SLP2494

CAS#: 329-98-6

RTECS: XT8040000

TSCA: TSCA 8(b) inventory: Phenylmethylsulfonyl fluoride

CI#: Not available.

Synonym: PMSF; Phenyl Methane Sulfonyl Fluoride

Chemical Name: alpha-Toluene Sulfonyl Fluoride

Chemical Formula: C7H7FO2S









Composition:


Phenylmethylsulfonyl fluoride 329-98-6 100

Toxicological Data on Ingredients: Phenylmethylsulfonyl fluoride LD50: Not available. LC50: Not available.


Potential Acute Health Effects:Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation.Corrosive to eyes and skin. The amount of tissue damage depends on length of contact. Eye contact can result in cornealdamage or blindness. Skin contact can produce inflammation and blistering. Inhalation of dust will produce irritation to gastro-intestinal or respiratory tract, characterized by burning, sneezing and coughing. Severe over-exposure can produce lungdamage, choking, unconsciousness or death.

Potential Chronic Health Effects:Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation.CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. Repeated exposure of the eyes to a low level of dust can produce eye irritation.Repeated skin exposure can produce local skin destruction, or dermatitis. Repeated inhalation of dust can produce varyingdegree of respiratory irritation or lung damage.



p. 2

Eye Contact: Check for and remove any contact lenses. Do not use an eye ointment. Seek medical attention.

Skin Contact:If the chemical got onto the clothed portion of the body, remove the contaminated clothes as quickly as possible, protectingyour own hands and body. Place the victim under a deluge shower. If the chemical got on the victim's exposed skin, suchas the hands : Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be particularlycareful to clean folds, crevices, creases and groin. If irritation persists, seek medical attention. Wash contaminated clothingbefore reusing.


Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.

Serious Inhalation:Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Ifbreathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It maybe hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious orcorrosive. Seek immediate medical attention.

Ingestion:Do not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, performmouth-to-mouth resuscitation. Seek immediate medical attention.



Flammability of the Product: May be combustible at high temperature.

Auto-Ignition Temperature: Not available.

Flash Points: Not available.

Flammable Limits: Not available.

Products of Combustion: These products are carbon oxides (CO, CO2), halogenated compounds.

Fire Hazards in Presence of Various Substances: Not available.


Fire Fighting Media and Instructions:SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet.


Special Remarks on Explosion Hazards: Not available.


Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container.

Large Spill:Corrosive solid. Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray toreduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition sources. Call forassistance on disposal.


p. 3

Precautions:Keep container dry. Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporatethe residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Never add water to thisproduct Wear suitable protective clothing If ingested, seek medical advice immediately and show the container or the label.May corrode glass. Store in an appropriate container.

Storage:May corrode glass. Store in an appropriate container. Keep container dry. Keep in a cool place. Ground all equipmentcontaining material. Corrosive materials should be stored in a separate safety storage cabinet or room.



Personal Protection:Splash goggles. Synthetic apron. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.




Physical state and appearance: Solid.

Odor: Not available.

Taste: Not available.


Color: Not available.

pH (1% soln/water): Not available.

Boiling Point: Decomposes.

Melting Point: 92°C (197.6°F)


Specific Gravity: Not available.







Dispersion Properties: Not available.

Solubility: Not available.

p. 4




Conditions of Instability: Not available.

Incompatibility with various substances: Not available.

Corrosivity: Corrosive in presence of glass.

Special Remarks on Reactivity: Not available.


Polymerization: No.


Routes of Entry: Ingestion.

Toxicity to Animals:LD50: Not available. LC50: Not available.

Chronic Effects on Humans: Not available.

Other Toxic Effects on Humans:Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of inhalation.


Special Remarks on Chronic Effects on Humans: Not available.

Special Remarks on other Toxic Effects on Humans: Not available.





Toxicity of the Products of Biodegradation: The products of degradation are more toxic.



Waste Disposal:


DOT Classification: CLASS 8: Corrosive solid.

Identification: : Corrosive solid, n.o.s. (Toluene sulfonyl fluoride) : UN1759 PG: III

Special Provisions for Transport: Not available.

p. 5


Federal and State Regulations: TSCA 8(b) inventory: Phenylmethylsulfonyl fluoride



WHMIS (Canada): CLASS E: Corrosive solid.

DSCL (EEC):This product is not classified according to the EU regulations.

HMIS (U.S.A.):

Health Hazard: 3

Fire Hazard: 1

Reactivity: 0

Personal Protection:


Health: 3

Flammability: 1

Reactivity: 0

Specific hazard:

Protective Equipment:Gloves. Synthetic apron. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriaterespirator when ventilation is inadequate. Splash goggles.




Created: 10/10/2005 11:22 AM

Last Updated: 05/21/2013 12:00 PM

The information above is believed to be accurate and represents the best information currently available to us. However, wemake no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assumeno liability resulting from its use. Users should make their own investigations to determine the suitability of the information fortheir particular purposes. In no event shall ScienceLab.com be liable for any claims, losses, or damages of any third party or forlost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if ScienceLab.comhas been advised of the possibility of such damages.

p. 1

1 2 0

He a lt h

Fire

Re a c t iv it y


2

1

0

E

Material Safety Data SheetImidazole MSDS


Product Name: Imidazole

Catalog Codes: SLI1588

CAS#: 288-32-4

RTECS: NI3325000

TSCA: TSCA 8(b) inventory: Imidazole

CI#: Not available.

Synonym:

Chemical Formula: C3H4N2









Composition:


Imidazole 288-32-4 100

Toxicological Data on Ingredients: Imidazole: ORAL (LD50): Acute: 220 mg/kg [Rat]. 880 mg/kg [Mouse].


Potential Acute Health Effects:Very hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Inflammation of the eyeis characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,occasionally, blistering.

Potential Chronic Health Effects:Very hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. CARCINOGENICEFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available. Repeated or prolonged inhalation of dust may lead to chronic respiratoryirritation.


Eye Contact:


p. 2

Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelidsopen. Cold water may be used. Do not use an eye ointment. Seek medical attention.

Skin Contact:After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin with runningwater and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. Cold water may be used.Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated clothing beforereusing.

Serious Skin Contact:Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medicalattention.

Inhalation: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.


Ingestion:Do not induce vomiting. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication thatthe toxic material was ingested; the absence of such signs, however, is not conclusive. Loosen tight clothing such as a collar,tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention.





Flash Points: CLOSED CUP: 145°C (293°F).


Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).

Fire Hazards in Presence of Various Substances: Not available.









Precautions:

p. 3

Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under afume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. In case of insufficient ventilation,wear suitable respiratory equipment If ingested, seek medical advice immediately and show the container or the label. Avoidcontact with skin and eyes

Storage:Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly closed. Keep in acool, well-ventilated place. Combustible materials should be stored away from extreme heat and away from strong oxidizingagents.













Boiling Point: 256°C (492.8°F)

Melting Point: 90°C (194°F)









Dispersion Properties: See solubility in water.

Solubility: Easily soluble in cold water.

p. 4




Conditions of Instability: Not available.

Incompatibility with various substances: Not available.

Corrosivity: Non-corrosive in presence of glass.

Special Remarks on Reactivity: Not available.


Polymerization: No.


Routes of Entry: Eye contact. Inhalation. Ingestion.

Toxicity to Animals: Acute oral toxicity (LD50): 220 mg/kg [Rat].

Chronic Effects on Humans: Not available.

Other Toxic Effects on Humans: Very hazardous in case of skin contact (irritant), of ingestion, of inhalation.



Special Remarks on other Toxic Effects on Humans: Not available.





Toxicity of the Products of Biodegradation: The products of degradation are more toxic.



Waste Disposal:






p. 5

Federal and State Regulations: TSCA 8(b) inventory: Imidazole



WHMIS (Canada):CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC). CLASS D-2B: Material causing other toxic effects(TOXIC).

DSCL (EEC):R22- Harmful if swallowed. R38- Irritating to skin. R41- Risk of serious damage to eyes.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 1

Reactivity: 0



Health: 2

Flammability: 1

Reactivity: 0

Specific hazard:

Protective Equipment:Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respiratorwhen ventilation is inadequate. Splash goggles.




Created: 10/10/2005 08:20 PM

Last Updated: 05/21/2013 12:00 PM


SAFETY DATA SHEET




Page 1 of 11




Product name Sodium acetate anhydrous for analysis EMSURE® ACS,Reag. Ph Eur






CAS-No. 127-09-3








India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6


number





SAFETY DATA SHEET





Page 2 of 11

2.2 Label elements



2.3 Other hazards

None known.


3.1 Substance

Formula CH₃COONa C₂H₃NaO₂ (Hill)

EC-No. 204-823-8



1907/2006

3.2 Mixture

Not applicable





shower.




irritant effects, Stomach/intestinal disorders


SAFETY DATA SHEET





Page 3 of 11









Combustible.

Vapours are heavier than air and may spread along floors.

Forms explosive mixtures with air on intense heating.





Further information












SAFETY DATA SHEET





Page 4 of 11



of dusts.







Hygiene measures



Storage conditions












See section 7.1.

SAFETY DATA SHEET





Page 5 of 11





Eye/face protection

Safety glasses

Hand protection

full contact:




splash contact:





















SAFETY DATA SHEET





Page 6 of 11



Form powder

Colour colourless

Odour odourless


pH 7.5 - 9.2

at 30 g/l

20 °C


(decomposition)

Boiling point/boiling range > 400 °C

(decomposition)

Flash point > 250 °C

Method: c.c.






Not applicable


SAFETY DATA SHEET





Page 7 of 11

Density 1.52 g/cm3

at 20 °C



at 20 °C


octanol/water

log Pow: -4.22

Bioaccumulation is not expected.






9.2 Other data

Ignition temperature 607 °C


10.1 Reactivity


A range from approx. 15 Kelvin below the flash point is to be rated as critical.



assumed.


hygroscopic



SAFETY DATA SHEET





Page 8 of 11

nitrates


Fluorine


Strong heating.







Acute oral toxicity


(RTECS)

Symptoms: Stomach/intestinal disorders


LC50 Rat: > 30 mg/l; 1 h ; dust/mist

(RTECS)

Symptoms: mucosal irritations



(RTECS)

Skin irritation

slight irritation

Eye irritation

slight irritation

SAFETY DATA SHEET





Page 9 of 11

Sensitisation




Ames test

Result: negative

(IUCLID)

Carcinogenicity




Teratogenicity

Did not show teratogenic effects in animal experiments. (IUCLID)





Aspiration hazard




appropriately.



12.1 Toxicity

Toxicity to fish

LC50 Lepomis macrochirus (Bluegill sunfish): 5,000 mg/l; 24 h

(Lit.)


EC50 Daphnia magna (Water flea): > 1,000 mg/l; 48 h

(IUCLID)

SAFETY DATA SHEET





Page 10 of 11


EC50 Pseudomonas putida: 7,200 mg/l; 18 h

(IUCLID)


Biodegradability

99 %; 28 d

OECD Test Guideline 301A




log Pow: -4.22












the product itself.






regulations.


SAFETY DATA SHEET





Page 11 of 11

Not relevant



regulations.



regulations.


Not relevant








Training advice






Palabora Copper (Pty) Limited

MSDS – Nickel Sulphate Date printed: 21 November 2014 Rev: 2.2 (Last revision date: 26 August 2013) Effective:13 March 2008 Any printed document is an uncontrolled document Page 1 of 13

SUPPLIER DETAILS

Supplier Name:

Address:

Person Responsible

for Updating MSDS:

Palabora Copper (Pty)

Limited

PO Box 65

1 Copper Road

Phalaborwa

1390

South Africa

Manager:

Environment & SHEQ

MS

Emergency Telephone

Number:

E-Mail Address:

Telephone Number:

Fax Number:

URL / WebPages:

+27 (0)15 780 2666

[email protected]

+27 (0)15 780 2281

+27 (0)15 780 2100

http://www.palabora.com/

1. PRODUCT IDENTIFICATION

Chemical Names and Synonyms: Nickel (II) Sulphate Hexahydrate, NiSO4.6H2O

UN Number: 3077

CAS Number: 10101-97-0 NIOSH Number: /

2. COMPOSITION

Nickel (II) Sulphate hexahydrate - 95% CAS Number: 10101-97-0 Molar Mass: 262.86 Molecular Formula: NiSO4.6H2O EC-Index Number: 028-009-00-5 EC-Number: 232-104-9

3. HAZARDOUS IDENTIFICATION

HAZARD CLASSIFICATION & LABELING: Human Health and Environment

ENDPOINT

GHS

CLASSIFICATION M-Factor

Hazard Class & Category

Code

Hazard Statement Code

Dermal Irritation/Skin Corrosion (GHS)

Skin Irrit. 2 H315 M = 1

Dermal Sensitization Skin Sens. 1 H317

Mutagenicity Muta. 2 H341

Acute Oral Toxicity Acute Tox. 4 H302

Acute Inhalation Toxicity Acute Tox. 4 H332

Chronic Toxicity/STOT-RE (inhalation)

STOT RE 1 H372

Reproductive Toxicity Repr. 1B H360D

Carcinogenicity (inhalation) Carc. 1A H350i

Respiratory Sensitization Resp. Sens. 1 H334

Acute Aquatic Environment Aquatic Acute 1 H400

Chronic Aquatic Environment Aquatic Chronic 1 H410

Material Safety Data Sheet Nickel Sulphate

mailto:[email protected]




Inhalation - Fresh air. Seek medical attention

Skin Contact - Remove contaminated clothing including shoes. Wash affected area with plenty of soap and water for at least 20 minutes.

Eye Contact - Rinse out with plenty of water with the eyelid held wide open. Seek medical attention.

Ingestion - Large quantities of water should be drunk. Seek medical attention.

Wounds - Cleanse thoroughly to remove any nickel sulphate particles.

5. FIRE FIGHTING MEASURES

Special Risks - Non-combustible. Development of hazardous combustion gases or vapours possible in the event of fire. The following may be present in the event of fire. Sulphur Oxides Special Protective Equipment for Fire Fighting - Do not stay in dangerous zone without suitable chemical protection clothing and self-contained breathing apparatus. Other Information - Contain escaping vapours with water. Prevent fire-fighting water from entering surface water or groundwater Suitable Extinguishing Media - Adapt to materials stored in the immediate vicinity.


Person-related precautionary measures: Avoid substance contact. Avoid generation of dusts. Do not inhale dusts.

Environment protection measures: Do not allow to enter aquatic system.

Procedures for cleaning/absorption: Pick up dry - Collect spills by sweeping or vacuuming with the vacuum exhaust passing through a high efficiency particulate arresting filter if exhaust is discharged into the work place. Avoid generation of dusts. Dispose of spills in accordance with local regulations. Clean up affected area.


Keep in the container supplied and keep container closed when not in use. Wear appropriate protective clothing, including waterproof gloves and nationally approved respirators. Follow local regulations regarding the storage of this material.



8. EXPOSURE CONTROLS / PERSONAL PROTECTION

The following source of information on Occupational Exposure Limits from Member States is the OSHA (European Agency for Safety and Health at work) website: http://osha.europa.eu/en/topics/ds/oel/index.stm/members.stm The following current national limit values for Nickel and its compounds (November 2010)

Area

Country

Current OELs (mg Ni / m3)

Soluble Metallic Nickel

oxide and

carbonate

Insoluble Nickel Carbonyl (liquid)

as Ni(CO)4

Europe Finland 0.1 1 0.1 0.1 0.007 (0.021 STEL) (both as Ni(CO)4)

Norway 0.05 0.05 - 0.05 0.007 (as Ni(CO)4)

UK 0.1 (MEL#) 0.5 (MEL

#) - 0.5 0.24 (STEL, as Ni)

France 0.1 1 (VME)*

1 1 0.12 (as Ni)

Germany No legally binding OEL currently in place

Belgium 0.1 1 - 0.2** 0.12 (as Ni)

Denmark 0.01 0.05 - 0.05 0.007 (as Ni(CO)4)

Italy 0. 1 1 - 1 0.12 (as Ni)

Non-

Europe

USA (OSHA) 1 1 - 1 0.007 (as Ni(CO)4)

USA - ACGIH (TLV) Non- enforceable standard

0.1#

1.5# - 0.2**

# 0.12 (as Ni) and 0.35 as Ni(CO)4

Canada - most jurisdictions

0.1 1.5 - 0.2**# 0.35 (as Ni(CO)4)

Canada - Ontario 0.1 1 - 0.2**#

0.35 (as Ni(CO)4)

Canada - BC 0.05 0.05 - 0.05 0.007 (as Ni(CO)4)

Canada - Qc, NT, NU, YT

0.1 1 - 1 0.35 (as Ni(CO)4)

Japan 0.1 - 0.1 0.1 0.007 (as Ni(CO)4)

Australia 0.1 1 - 1$ 0.12 (as Ni)

South Africa 0.1 0.5 - 0.5** 0.24 (STEL, as Ni)

*VME = Valeur Moyenne d'Exposition. The value of 1 mg/rn

3 applies to nickel carbonate, dihydroxide, subsulfide,

monoxide, sulphide trioxide and for other chemical forms not otherwise specified, such as "insoluble nickel compounds" and nickel sulfide roasting fume and dust. ** For nickel subsulfide the value is 0.1 mg Ni/m

3 as inhalable.

# Inhalable

$ Nickel sulphides roasting fumes only

MEL Maximum Exposure Limit STEL Short term exposure level OEL Occupational exposure limit

http://osha.europa.eu/en/topics/ds/oel/index.stm/members.stm



TWA Time-weighted average exposure TLV Threshold Limit Value

Personal Protective Equipment: Respiratory protection - Required when dust is generated Eye Protection - Required Hand Protection - Required

Industrial Hygiene: Protective clothing should be selected specifically for the working place, depending on the concentration and quantity of the hazardous substances handled. Avoid repeated skin and eye contact. Wear goggles or face shield. Wear suitable protective clothing and waterproof gloves. Wash skin thoroughly after handling and before eating, drinking or smoking. Launder clothing and gloves as needed. Application of skin-protective barrier cream is recommended.


Form: Crystals Colour: Green Odour: Odourless Formula: NiSO4.6H2O pH value @ 100g/l H2O, 20 deg C 4.3 - 4.7 Melting temperature 53 deg C (loss of water of crystallisation on heating) Boiling temperature not applicable Ignition temperature not applicable Flash point not applicable Explosion limit Non-explosive Relative vapour density not applicable Relative density @ 20 deg C 2.07 g/cm

3

Bulk Density ± 1000 kg/m3 Solubility in water @ 20 deg C 625 g/l water @ 100 deg C 3407 g/l Thermal decomposition > 700 deg C


Conditions to be avoided: Strong Heating Substances to be avoided: Strong Acids Hazardous decomposition products: In the event of fire - toxic vapours (Sulphur Oxides) Further Information: Releasing water of crystallization - when heated.




Toxicity endpoints Description of effects

Absorption ORAL = 30% from food during fasting; 5% from absorption of nickel from food, soil, dust and from water consumed with food [In vivo rat, human study and modeling of human data] (Ishimatsu et al., 1995; Sunderman et al., 1989; Nielsen et al., 1999; Diamond et al.,1998; EURA, 2008-2009) DERMAL = 2% [In vivo human skin stripping and in vitro human stratum corneum] (Hostynek et al., 2001; Tanojo et al., 2001; EURA, 2008-2009) INHALATION = 100% (aerodynamic diameter below 5 µm = respirable fraction), negligible (aerodynamic diameters >5 µm = non-respirable fraction) [Animal studies and read across from nickel chloride rat in vivo intratracheal instillation studies] (Medinsky et al., 1987; Benson et al., 1995; Carvalho and Ziemer, 1982; English et al., 1981; Clary, 1975; EURA, 2008-2009)

Acute toxicity ORAL: LD50= 361.9 mg NiSO4·6H2O/kg bw. Classified as Category 4. [OECD Guideline 425] (EPSL, 2009a; FDRL, 1983) DERMAL: No studies have been found on acute toxicity by the dermal route but dermal absorption is low so toxicity is not expected. INHALATION: LC50= 2.48 mg NiSO4·6H2O/L. Classified as Category 4 [OECD Guideline 403 study] (EPSL, 2009b)

Skin

corrosion/irritation

Nickel sulphate is classified as Category 2 for skin irritaton with a 20% concentration limit. [Human patch testing] (Frosch and Kligman, 1976; Seidenari et al., 1996)

Serious eye

damage/irritation

Nickel sulphate is not an eye irritant. [OECD Guideline 405 study] (SLI, 1999)

Respiratory or skin

sensitisation

DERMAL: Nickel sulphate is a dermal sensitizer classified as Category 1. [Guinea Pig Maximization Test sudies] (Rohold et al., 1991; FDRL, 1986; Lammintausta et al., 1985; Nielsen et al., 1992) RESPIRATORY: Nickel sulphate is a respiratory sensitizer classified as Category 1. [Weight of evidence from human case reports] (Block and Yeung, 1982; Malo et al., 1982; Malo et al., 1985; McConnell et al., 1973; Novey et al., 1983)

Germ cell

Mutagenicity

Nickel sulphate is mutagenic and is classified Category 2. [In vivo mutagenicity testing and in vivo testing weight of evidence] (Larramendy et al., 1981; Oller and Erexson, 2007)

Carcinogenicity ORAL: Nickel sulphate is not carcinogenic by the oral route of exposure. [OECD Guideline 451 and EPA OPPTS 870.4200 study] (Heim et al., 2007) DERMAL: Not relevant since negligible amount of absorption by dermal exposure. INHALATION: Nickel sulphate in currently classified as Category 1A for inhalation exposure. [Human epidemiological studies and 2-year rat inhalation OECD Guideline 453] (Doll et al., 1990; Grimsrud et al., 2002; Antilla et al., 1998; Roberts et al., 1989; Andersen et al., 1996; Pang et al., 1996; NTP, 1996)

Reproductive toxicity Nickel sulphate is a Category 1B reproductive toxicant. [OECD Guideline 416- 2 generation study] (SLI, 2000)

STOT-single

exposure

Available data do not indicate potential for single target organ toxicity. (References are included in other endpoint summaries.)

STOT-repeated dose

toxicity

ORAL: Lack of toxicity demonstrated in available studies. (References are included in other endpoint summaries.) DERMAL: Lack of toxicity from dermal exposure since dermal absorption is negligible. INHALATION: Classified as Category 1 for inhalation exposure due to lung effects. NOAEC = 0.027 mg Ni/m³ [Data from 2-year rat inhalation OECD Guideline 453 study] (NTP, 1996)

Aspiration hazard Not applicable.




Endpoints Description of effects

Toxicity Ecotoxicity Reference Values (ERVs) for nickel substances:

Acute = 120 µg Ni/L (pH 6), 68 µg Ni/L (pH 8)

Chronic = 2.4 µg Ni/L

Short-term toxicity to aquatic invertebrates:

Invertebrates 48h LC50 (immobilization) (freshwater): Range from 0.013 mg Ni/L [Ceriodaphnia dubia] (Schubauer-Berigan et al., 1993) to 4970 mg Ni/L [Daphnia magna] (Chapman et al., 1980) (immobilization).

Invertebrates 48h LC50 mortality (marine): Range from 0.23 mg/L [Haliotis refescens] (Hunt et al., 2002) to 415 mg/L (Penaeus duorarum] (Bentley et al., 1975).

Short-term toxicity to fish:

Fish 96 hour (freshwater): Range from 0.23 mg Ni/L [Pimephales promelas] (Hoang et al., 2004) to 320 mg Ni/L [Brachydanio rerio] (Janssen Pharmaceutica, 1993) (mortality).

Fish 96h LC50 mortality values (marine): Range from 26.6 mg Ni/L [Atherinops affinis] (Hunt et al., 2002) to 350 mg Ni/L [Fundulus heteroclitus] (Eisler and Hennekey, 1977).

Long-term toxicity to aquatic invertebrates:

Invertebrates population growth rate (15 species) (freshwater): Range of 1.4 μg/L [Lymnaea stagnalis] (growth) to 1379 µg/L [Brachionus calyciflorus] (Stubblefield and Van Genderen, 2007).

Invertebrates (9 species) (marine): Range from 22.5 µg Ni/L [Neanthes arenaceodentata reproduction] (Parametrix 2007b) to 335 µg Ni/L [Strongylocentrotus purpuratus development] (Parametrix 2007c).

Long-term toxicity to fish:

Fish (3 species) (freshwater): Range of 40 µg Ni/L [Brachydanio rerio for hatchability] to 1548 µg Ni/L [Oncorhynchus mykiss for growth] (Deleebeeck et al., 2007).

Fish EC10 (2 species) (marine): Range from 3599 µg Ni/L [Atherinops affinis growth] (Hunt et al., 2002) to 20760 µg Ni/L [Cyprinodon variegatus growth] (Golder Associates, 2007).

Toxicity to aquatic algae and cyanobacteria:

Algae growth rate (9 values) (freshwater): Range of 12.3 µg Ni/L [Scenedesmus accumulates] (Deleebeeck et al., 2006) to 51.8 µg Ni/L [Coelastrum microporum] (Deleebeeck et al., 2006) (growth rate)

Algae growth (4 species) (marine): Range from 97 µg Ni/L [Macrocystis pyrifera] (Golder, 2007) to 17891 µg Ni/L [Dunaliella tertiolectaI] (Parametrix 2007a).

Toxicity to aquatic plants other than algae:

Higher aquatic plants growth inhibition (freshwater): Range of 8.2 µg Ni/L [Lemna gibba] (Klain & Knuteson, 2003) and 80 µg Ni/L [Lemna minor] (Antunes, 2007)

Toxicity to microorganisms:

Inhibition of Oxygen Consumption EC50: 33 mg/L [Test for by Activated Sludge- ISO 8192] (Cokgor et al.,2007)

Toxicity to other aquatic organisms:

Amphibians (3 species) (freshwater): Range of 84.5 µg Ni/L to 13,147 µg Ni/L [Xenopus laevis malformation] (Hopfer et al., 1991).

Sediment toxicity:

Pending outcome of sediment testing program (conclusion i of EU Existing Substances Risk Assessment).



Toxicity to soil macro-organisms:

Macroinvertebrates (acute): Range from 52 mg Ni/kg dw [Lumbicis terrestris mortality] (Furst et al., 1993) to 2,500 mg Ni/kg dw [Caenorhabditis elegans mortality] (Boyd and Williams, 2003).

Invertebrates (6 species) (chronic): Range from 36 mg Ni/kg [Folsomia candidate reproduction] to 1140 mg Ni/kg [Eisenia fetida reproduction] (Ghent University, 2005).

Toxicity to terrestrial plants:

Plants EC50 (4 d) values (acute): Range from ≥54.5 mg/kg soil d.w. to ≤1928.2 mg/kg [Hordeum vulgare root elongation] (Thakali et al., 2006).

Plants (11 species) (chronic): Range from 10 mg Ni/kg [Spinacea oleracea total yield] (Willaert & Verloo, 1988) to 1127 mg Ni/kg [Hordeum vulgare root yield] (Rothamsted Research, 2005).

Toxicity to soil micro-organisms:

Microbial processes (12 processes) (chronic): Range from 28 mg Ni/kg [nitrification] (Smolders, 2000) to 2542 mg Ni/kg [respiration] (Doelman & Haanstra, 1984).

Enzyme activity in soil (chronic): Range from 7.9 mg Ni/kg [dehydrogenase] (Welp, 1999) to 7084 mg Ni/kg [arylsulfatase activity] (Haanstra and Deolman, 1991).

Microbial species growth (13 species) (chronic): Range from 13 mg Ni/kg [Aspergillus clavatus] to 530 mg Ni/kg for [Trichoderma viride] (Babich & Stotzky, 1982).

Persistence and

degradability

Not applicable to inorganic substances. Information about the extent of nickel partitioning from the water column and transformation to less toxic or non-toxic nickel species is currently being evaluated in the context of the CLP criteria. This evaluation will be completed and available by 1 December 2012.

Bioaccumulative

potential

Aquatic bioaccumulation

Freshwater aqueous: Range from 0.8 [Oncorhynchus mykiss, muscle w.w., 180 d flow-through] (Calamari et al., 1982) to 5613 [Anacystis nidulans, whole body d.w., 48h static] (Azeez and Banerjee, 1991)

Freshwater sediment: 6150 [Cerastoderma edule, whole body w.w., field study] (Bryan and Hummerstone, 1977)

Saltwater aqueous: Range from 3 (C. margaritacea, whole body w.w., field study] (Walting, 1983) to 26500 (Cerastoderma edule whole body d.w., 26 d semi-static] (Waegeneers and Smolders, 2003)

McGeer et al. (2003) aggregated whole fish tissue data published by Lind et al. (1978) and Blaylock and Frank (1979). A BCF of 270 was calculated from this linear relationship. Where C. edule was a relevant prey item for marine food chains, the value of 1631 (Boyden, 1975) was relevant.

Terrestrial bioaccumulation (BSAF)

Range from 0.013 [lettuce, edible fraction] (DiSalvatore et al., 2009) to 1.86 [Allolobophora caligonosa, whole body d.w. (Plaggen soil)] (Ma, 1982)

All BAFs were pooled and log normally distributed, resulting in a BAF geometric mean from the cumulative frequency distribution of 0.30 (EURA, 2008-2009)



Mobility in soil Kp- Soil: log Kp soil 2.86 [Aqua regia digestion- ISO 11466, 46 European soils](De Groot et al., 1998).

Results of PBT and

vPvB assessment

The PBT and vPvB criteria of Annex XIII to the Regulation does not apply to inorganic substances, such as nickel and inorganic nickel compounds.

Other adverse effects Not applicable.


Product: A distinction must be made between "wastes for recycling" and "wastes for disposal". Please contact the competent body (authority or waste disposal company) where you will obtain information on recycling or disposal.

Packaging: Disposal to be in compliance with official regulations. Handle contaminated packaging in the same way as the substance itself. If not officially specified differently, non-contaminated packaging may be treated like household or recycled.


Land transport - Transport according to SABS code of practice (0230, 0231,0232) Sea Transport - Ship in a closed container. UN Proper Shipping Name - ENVIRONMENTALLY HAZARDOUS SUBSTANCE SOLID N.O.S. (Nickel Sulphate) Transport Hazard Class: 9 Packaging Group: III The transport regulations are cited according to International Regulations, and may depend on Country-to-Country and volume to be transported.




Labeling: Hazard pictograms:

Signal word: danger Hazard statements:

LABELLING HAZARDOUS STATEMENT CODE DESCRIPTION

Hazard Statement

Code

H302

H315

H317

H332

H334

H341

H350i

H360D

H372

H410

H302 = Harmful if swallowed

H315 = Causes skin irritation

H317 = May cause an allergic skin reaction

H332 =Harmful if inhaled

H334 = May cause allergy or asthma symptoms or breathing difficulties if inhaled

H341 = Suspected of causing genetic defects

H350i = May cause cancer via inhalation

H360D = May damage the unborn child

H372 =Causes damage to lungs through prolonged or repeated exposure via inhalation

H400 = Very toxic to aquatic life

H410 =Very toxic to aquatic life with long lasting effects

EC No - 232-104-9


References: Toxicity Summary Nickel Sulphate

References: Ecotoxicity Summary Ni and Ni compounds

Refer to Annexure A of this MSDS – NOTE: Please don’t print the list of references – save paper

DISCLAIMER

All information is given in good faith but without guarantee in respect of accuracy, and no responsibility is accepted for errors or omissions or the consequences thereof. It is the user's obligation to determine the conditions of safe use of the material, all risks of use of the product are therefore assumed by the user and we expressly disclaim all warranties of every kind and nature, including warranties of merchantability and fitness for a particular purpose in respect to the use or suitability of the product.


Page 10 of 13

Annexure A: List of References

References: Toxicity Summary Nickel Sulphate

Andersen A, Engeland A, Berge SR, Norseth T. (1996). Exposure to nickel compounds and smoking in relation to incidence of lung and nasal cancer among nickel refinery workers. Occup Environ Med, 53:708-13.

Anttila A, Pukkala E, Aitio A, Rantanen T, Karjalainen S. (1998). Update of cancer incidence among workers at a copper/nickel smelter and nickel. Int Arch Occup Environ Health, 71:245-50.

Benson JM, Chang IY, Cheng YS, Hahn FF, Kennedy CH, Barr EB, Maples KR, Snipes MB (1995). Particle clearance and histopathology in lungs of F344/N rats and B6C3F1 mice inhaling nickel oxide or nickel sulfate. Fundam Appl

Toxicol, 28:232-244.

Block, G. T. and M. Yeung (1982). Asthma induced by nickel. JAMA, 247(11):1600-2. Carvalho SMM and Ziemer PL. (1982). Distribution and clearance of

63Ni administered as

63NiCl2 in the rat: Intratracheal

study. Arch Environ Contam Toxicol, 11:245-248.

Clary JJ. (1975). Nickel chloride-induced metabolic changes in the rat and guinea pig. Toxicol Appl Pharmacol.; 31:55-65.

Diamond GL, Goodrum PE, Felter SP and Ruoff WL. (1998). Gastrointestinal absorption of metals. Drug Chem Toxicol, 21:223-251.

Doll et al. (International Committee on Nickel Carcinogenesis in Man (ICNCM)). (1990). Report of the International Committee on Nickel Carcinogenesis in Man. Scand J Work Environ Health, 16:1-84.

EPSL (2009a). Acute Oral Toxicity Up and Down Procedure in Rats. Testing laboratory: Eurofins Product Safety Laboratories (EPSL); Dayton, New Jersey, USA. Owner company: Nickel REACH Consortia Members. Study number: 28434. Report date: 2009-12-01.

EPSL (2009b). Acute Inhalation Toxicity Study in Rats - Defined LC50. Testing laboratory: Eurofins Product Safety Laboratories (EPSL); Dayton, New Jersey, USA. Owner company: Nickel REACH Consortia Members. Study number: 27562. Report date: 2009-09-29.

EURA (2008-2009). European Union Risk Assessment Report for Nickel Sulphate. Danish Environmental Protection Agency. Risk Assessment for Nickel Sulphate (CAS No. 7786-81-4)(EINECS No. 232-104-9) Prepared in Relation to Council Regulation (EEC) 793-93. http://www.mst.dk/English/Chemicals/Substances_and_materials/Nickel/ English JC, Parker RD, Sharma RP and Oberg SG. (1981). Toxicokinetics of nickel in rats after intratracheal administration of a soluble and insoluble form. Am Ind Hyg Assoc J, 42:486-492.

FDRL (Food & Drug Research Laboratories, Inc.) (1983). Acute Oral LD50 Study in Rats (OECD). Test Article 83-0506 (Nickel Sulfate). Testing laboratory: Food & Drug Research Laboratories, Inc. (FDRL). Report no.: FDRL Study No. 7702A. Owner company: Study conducted for NiPERA, Inc.

FDRL (Food & Drug Research Laboratories, Inc.) (1986). Dermal Contact Sensitization Study of Nickel Sulfate, Nickel Oxide, CT-243-850, and CT-243-85F. Guinea Pig Maximization Test. Testing laboratory: Food & Drug Research Laboratories, Inc. (FDRL). Report no.: 8932. Owner company: NiPERA, Inc. Report date: 1986-04-07.

Frosch PJ, Kligman AM (1976): The chamber scarification test for irritancy. Contact Dermatitis, 2:314-324.

Grimsrud TK, Berge SR, Haldorsen T, Andersen A. (2002). Exposure to different forms of nickel and risk of lung cancer. Am J Epidemiol, 156:1123-1132.

Heim KE, Bates HK, Rush RE, and Oller AR (2007). Oral carcinogenicity study with nickel sulfate hexahydrate in Fischer 344 rats. Toxicology and Applied Pharmacology. 224:126–137. Hostynek, J.J.; Dreher, F.; Nakada, T.; Schwindt, D.; Anigbogu, A.; Maibach, H.I. (2001) Human Stratum Corneum

Adsorption of Nickel Salts: Investigation of Depth Profiles by Tape Stripping in vivo. Acta Derm Venereol S212: 11-18. Ishimatsu S, Kawamoto T, Matsuno K, Kodama Y. (1995). Distribution of various nickel compounds in rat organs after oral administration. Biol Trace Elements Res, 49 (1):43–52.

Lammintausta K, Kalimo K, and Jansen CT. (1985). Experimental nickel sensitization in the guinea pig: comparison of

http://www.mst.dk/English/Chemicals/Substances_and_materials/Nickel/


Page 11 of 13

different protocols. Contact Dermatitis, 12:258-262.

Larramendy ML, Popescu NC, and DiPaolo JA (1981). Induction by inorganic metal salts of sister chromatid exchange and aberrations in human and Syrian hamster cell strains. Environmental Mutagenesis, 2:597-606.

Malo JL, Cartier A, Doepner M, Nieboer E, Evans S, and Dolovich J. (1982). Occupational asthmatic caused by nickel sulfate. J Allergy Clin Immunology, 69:55-59.

Malo JL, Cartier A, Gagnon G, Evans S, and Dolovich J. (1985). Isolated late asthmatic reaction due to nickel sulphate without antibodies to nickel. Clinical Allergy, 15:95-99.

McConnell LH, Fink JN, Schlueter DP and Schmidt MG, Jr. (1973). Asthma caused by nickel sensitivity. Ann Intern Med, 78(6):888-90.

Medinsky MA, Benson JKM, Hobbs CH (1987). Lung clearance and disposition of 63

Ni in F344/N rats after intratracheal

instillation of nickel sulphate solutions. Environ Res, 43:168-178.

NTP (National Toxicology Program). (1996a). Technical Report on the toxicology and carcinogenesis studies of nickel sulfate hexahydrate (CAS NO. 10101-97-0) in F344/N rats and B6C3F1 mice (inhalation studies). National Institute of Health, Springfield, VA. Washington DC. pp. 376. Testing laboratory: NTP (National Toxicology Program). NTP Technical Report No. 454. Owner company: National Institute of Health, Springfield, VA. Washington DC. Study number: NIH Publication No. 96-3370.

Nielsen, G. D., A. E. Rohold, and K. E. Andersen. (1992). Nickel contact sensitivity in the guinea pig. Acta Derm. Venereol. 72(1):45-48.

Nielsen GD, Søderberg U, Jørgensen PJ, Templeton DM, Rasmussen SN, Andersen KE, Grandjean P (1999). Absorption and retention of nickel from drinking water in relation to food intake and nickel sensitivity. Toxicol Appl Pharmacol, 154:67-75.

Novey, H. S., M. Habib and I. D. Wells (1983). "Asthma and IgE antibodies induced by chromium and nickel salts." J Allergy Clin Immunol, 72(4):407-12.

Oller A and Erexson G (2007). Lack of micronuclei formation in bone marrow of rats after repeated oral exposure to nickel sulfate hexahydrate. Mutation research, 626(1-2):102-110.

Pang D, Burges DC, Sorahan T. (1996). Mortality study of nickel platers with special reference to cancers of the stomach and lung, 1945-93. Occup Environ Med 53, 714-7.

Rohold AE, Nielsen GD, and Andersen KE (1991). Nickel sulphate-induced contact dermatitis in the guinea pig maximization test: A dose-response study. Contact Dermatitis, 24(1):35-39.

SLI (1999). A Primary Eye Irritation Study in Rabbits with Nickel Sulphate Hexahydrate. Testing laboratory: Springborn Laboratories, Inc. Report no.: SLI Study No. 3472.2. Owner company: Study conducted for NiPERA, Inc. Report date: 1999-12-23.

SLI (2000). An oral (gavage) two-generation reproduction toxicity study in Sprague-Dawley rats with nickel sulfate hexahydrate. Testing laboratory: Springborn Laboratories, Inc. Spencerville, Ohio, USA. Report no.: SLI Study No.

Seidenari, S., Belletti, B., Mantovani, L., and Pepe, P. (1996). Nickel sulfate 5-20% aq. Does not evoke irritation on the skin of non-nickel-sensitive subjects. Contact Dermatitis, 35:260-261.

Sorahan T. (2004). Mortality of Workers at a Plant Manufacturing Nickel Alloys, 1958-2000. Occupational Medicine, 54:28-34.

Sunderman FW, Jr, Hopfer SM, Sweeny KR, Marcus AH, Most BM, Creason J (1989). Nickel absorption and kinetics in human volunteers. Proc Soc Exp Biol Med, 191:5-11.

Tanojo H, Hostynek JJ, Mountford HS, and Maibach HI. (2001). In vitro permeation of nickel salts through human stratum corneum. Acta Derm Venereol, Suppl 212:19-23.


Page 12 of 13

References: Ecotoxicity Summary Ni and Ni compounds Antunes P. (Stantec Consulting Ltd) (2007). Testing the toxicity of Ni to Lemna minor in natural waters and standard test media. Testing laboratory: Stantec Consulting Ltd., Guelph, Ontario. Report no.: 162704389. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Azeez PA and Banerjee DK. (1991). Nickel uptake and toxicity in cyanobacteria. Toxicological and Environmental Chemistry; 30:43-50. Babich H and Stotzky G. (1982). Toxicity of nickel to microorganisms in soil: influence of some physiochemical characteristics. Environmental Pollution; (Series A) 29:303-315. Bentley RE, Heitmuller T, Sleight III BH, and Parrish PR. (1975). Acute toxicity of nickel to bluegill (Lepomis macrochirus), rainbow trout (Salmo gairdneri), and pink shrimp (Penaeus duorarum). U. S. EPA, Criteria Branch (WH-585). Washington, D. C. Order No. WA-6-99-1414-B. Owner company: US EPA. Blaylock BG and Frank ML. (1979). A comparison of the toxicity of nickel to the developing eggs and larvae of carp (Cyprinus carpio). Bull. Environ. Contam. Toxicol.; 21(4/5):604-611. Boyd WA and Williams PJ (2003). Availability of metals to the nematode Caenophabditis elegans: Toxicity based on total concentrations in soil and extracted fractions. Env Toxicol and Chem, 22(5):1100-1106. Boyden CR (1975). Distribution of some trace metals in Poole Harbor, Dorset. Marine Pollution Bulletin, 6(12):180-187. Bryan GW and Hummerstone LG (1977). Indicators of heavy metal contamination in the looe estuary (cornwall) with particular regard to silver and lead. J Mar Bio Ass UK, 57:75-92. Calamari D, Gaggino GF, and Pacchetti G (1982). Toxicokinetics of low levels of Cd, Cr, Ni and their mixture in long-term treatment of Oncorhynchus mykiss. Chemosphere, 11(1):59-70. Chapman GA, Ota S, and Recht F (1980). Effects of water hardness on the toxicity of metals to Daphnia magna. US EPA, Corvallis, OR. 17p. Owner company: US EPA. Cokgor EU, Ozdemir S, Karahan O, Insel G, and Orhon D. (2007). Critical appraisal of respirometric methods for metal inhibition on activated sludge. Journal of Hazardous Materials, B139:332–339. De Groot AC, Peijnenburg WJGM, van den Hoop MAGT, Ritsema R, and van Veen RPM. (1998). Heavy metals in Dutch field soils: an experimental and theoretical study on equilibrium partitioning. Testing laboratory: Laboratory of Ecotoxicology, National Institute of Public Health and the Environment. Report no.: 607220001. Owner company: Laboratory of Ecotoxicology, National Institute of Public Health and the Environment. Deleebeeck NME, De Schamphelaere KAC, Muyssen BTA, De Laender F, and Janssen CR. (Ghent University) (2006). Ni toxicity to soft vs. hard water organisms: a comparison of sensitivity and bioavailability. Testing laboratory: Ghent University (UGent). Laboratory of Environmental Toxicology and Aquatic Ecology. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Deleebeeck NME, Muyssen BTA, De Laender F, Janssen CR, and De Schamphelaere KAC. (2007). Comparison of nickel toxicity to Cladocerans in soft versus hard surface waters. Aquatic Toxicology; 84:223-235. Testing laboratory: Laboratory of Environmental Toxicology and Aquatic Ecology, Gent University, Jozef Plateaustraat 22, Gent, Belgium. DiSalvatore M, Carratu G, and Carafa AM. (2009). Assessment of heavy metals transfer from a moderately polluted soil into the edible parts of vegetables. Journal of Food, Agriculture, and Environment; 7(2):683-688. Doelman P and Haanstra L. (1984). Short-term and long-term effects of cadmium, chromium, copper, nickel, lead and zinc on soil microbial respiration in relation to abiotic soil factors. Plant and Soil. 79:317-327. ECHA (European Chemicals Agency) (2011). Guidance on the Application of the CLP Criteria. ECHA Reference: ECHA-11-G-06-EN. Date: 04/2011. EURA (European Union Risk Assessment) (2008-2009). Danish Environmental Protection Agency. Background document in support of individual risk assessment reports of nickel compounds. Danish Environmental Protection Agency. Prepared in Relation to Council Regulation (EEC) 793-93. http://www.mst.dk/English/Chemicals/Substances_and_materials/Nickel/ Eisler R and Hennekey RJ. (1977). Acute toxicities of Cd

+2, Cr

+6, Hg

2+, Ni

2+ and Zn

2+ to estuarine macrofauna. Arch.

Environ. Contam Toxicol, 6:315-323. Ghent University/Euras (2005). NiPERA Research Project - Bioavailability and ageing of nickel in soils: Invertebrate toxicity testing. Testing laboratory: Ghent University (UGent) - Laboratory of Environmental Toxicology and Aquatic Ecology. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Report date: 2005-04-26. Golder Associates Ltd. (2007). Laboratory report on: Toxicity of nickel to giant kelp (Macrocysts pyrifera) and sheepshead minnow (Cyprinodon vareigatas). Testing laboratory: Golder Associated Ltd. Report no.: 06-1424-008. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Report date: 2007-02-15. Haanstra L and Doelman P (1991). An ecological dose-response model approach to short- and long-term effects of heavy metals on arylsulphatase activity in soil. Biology and Fertility of Soils, 11:18-23. Hoang, TC, Tomasso JR, and Klaine SJ. (2004). Influence of water quality and age on nickel toxicity to fathead minnows (Pimephales promelas). Environ. Toxicol. Chem.; 23(1):86-92. Hopfer SM, Plowman MC, Sweeney KR, Bantle JA, and Sunderman Jr. FW. (1991). Teratogenicity of Ni+2 in Xenopus laevis, assayed by the FETAX procedure. Biological Trace Element Research, 29:203-216.


Page 13 of 13

Hunt JW, Anderson BS, Phillips BM, Tjeerdema RS, Puckett HM, Stephenson M, Tucker DW, and Watson D. (2002). Acute and chronic toxicity of nickel to marine organisms: Implications for water quality criteria. Environmental Toxicology and Chemistry; 21(11):2423 - 2430. Janssen Pharmaceutica (1993). The acute toxicity of nickel chloride in the zebra fish (Brachydanio rerio). Testing laboratory: Study conducted by Janssen Pharmaceutica N. V., Beerse, Belgium. Report no.: AFBr/0015. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Report date: 1993-01-19. Klaine SJ and Knuteson S. (Clemson Institute of Environmental Toxicology, Clemson University) (2003). Toxicity of nickel to duckweeds. Clemson Institute of Environmental Toxicology, Clemson University, Pendleton, South Carolina. Testing laboratory: Clemson Institute of Environmental Toxicology, Clemson University. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Report date: 2003-12-31. Lind D, Alto K, and Chatterton S. (1978b). Regional Copper-Nickel Study: Aquatic toxicology study. Minnesota Environmental Quality Board. pp. 1-53. Ma W (1982). The influence of soil properties and worm-related factors on the concentration of heavy metals in earthworms. Pedobiologia, 24:109-119. McGeer JC, Brix KV, Skeaff JM, DeForest DK, Brigham SI, Adams WJ, and Green AS. (2003). The inverse relationship between bioconcentration factor and exposure concentration for metals: implications for hazard assessment of metals in the aquatic environment. Environ. Toxicol. Chem.; 22(5):1017-1037. Parametrix, Inc. (2007a). Toxicity of nickel in natural waters to the marine algae (Dunaliella tertiolecta). Testing laboratory: Parametrix Environmental Research Laboratory, 33972 Texas Street SW, Albany, OR 97321. Report no.: 3831-425. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Report date: 2007-05-14. Parametrix, Inc. (2007b). Toxicity of nickel to Neanthes arenaceodentata. Testing laboratory: Parametrix Environmental Research Laboratory, 33972 Texas Street SW, Albany, OR 97321. Report no.: 3831-457. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Report date: 2007-05-16. Parametrix, Inc. (2007c). Toxicity of nickel to the sand dollar, Dendraster excentricus, and the purple sea urchin, Strongylocentrotus purpuratus. Testing laboratory: Northwestern Aquatic Sciences, 3814 Yaquina Bay Rd., Newport, OR 97365. Report no.: 760-8. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Report date: 2007-03-07. Rothamsted Research (2005). NiPERA Research Project - Development of a predictive model of bioavailability and toxicity of nickel in soils: Plant toxicity. Testing laboratory: Rothamsted Research. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Report date: 2005-01-01. Schubauer-Berigan MK, Dierkes JR, Monson PD, and Ankley GT. (1993). pH-Dependent toxicity of Cd, Cu, Ni, Pb and Zn to Ceriodaphnia dubia, Pimephales Promelas, Hyalella azteca and Lumbriculus variegates. Environmental Toxicology and Chemistry, 12:1261-1266. Smolders E. (2000). The effect of NiSO4.6H2O, elemental Ni and green NiO on nitrogen transformation in soil. Final Report. Reported in conjunction with the Nickel Producers Environmental Research Association (NiPERA), Inc. 22p. Testing laboratory: University of Leuven. Report date: 2000-01-01. Stubblefield W and Van Genderen E (Parametrix, Inc) (2007). Validation of nickel biotic ligand model predictions for selected non-standard organisms. Testing laboratory: Parametrix, Inc. Owner company: Nickel Producers Environmental Research Association (NiPERA), Inc. Thakali S, Allen HE, Di Toro DM, Ponizovsky AA, Rooney GP, Zhao FJ, and McGrath SP (2006). A terrestrial biotic ligand model. 1. development and application to cu and ni toxicities to barley root elongation in soils. Environ Sci Technol, 40:7085-7093. Waegeneers N and Smolders E. (2003). Secondary poisoning of nickel to marine birds. EU Risk Assessment. Testing laboratory: Laboratory for soil and water management, KasteelPark Arenberg 20, B-3001 Heverlee-Belgium. Owner company: NiPERA, Inc. Walting HR (1983). Accumulation of seven metals by Crassostrea gigas, Crassostrea margaritacea, Perna perna, and Choromytilus meridionalis. Bull. Environ Contam Toxicol, 30:317-322. Welp G. (1999). Inhibitory effects of the total and water-soluble concentrations of nine different metals on the dehydrogenase activity of a loess soil. Biology and Fertility of Soils; 30:132-139. Willaert G and Verloo M. (1988). Biological effects of nickel species and their determination in plant and soil. Plant and Soil; 107:285-292.

p. 1

1 2 0

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E

Material Safety Data SheetDL-Dithiothreitol MSDS


Product Name: DL-Dithiothreitol

Catalog Codes: SLD3577

CAS#: 27565-41-9

RTECS: XO8576500 and EK1610000

TSCA: TSCA 8(b) inventory: No products were found.

CI#: Not available.

Synonym: DL-Dithiothreitol, Electrophoresis Grade;Cleland's Reagent; DL-DTT; 2,3-butanediol, 1,4-dimercapto-, DL-threo-; DL-threo-1,4-Dimercapto-2,3-butanediol; rac-Dithiothreitol

Chemical Name: Threitol, 1,4-dithio-, DL-

Chemical Formula: C4-H10-O2-S2









Composition:


{DL-}Dithiothreitol 27565-41-9 100

Toxicological Data on Ingredients: DL-Dithiothreitol LD50: Not available. LC50: Not available.


Potential Acute Health Effects: Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation.

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast. TERATOGENICEFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to central nervoussystem (CNS). Repeated or prolonged exposure to the substance can produce target organs damage.


Eye Contact:


p. 2

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15minutes. Get medical attention.

Skin Contact:In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminatedclothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.


Inhalation:If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention.


Ingestion:Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconsciousperson. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar,tie, belt or waistband.





Flash Points: CLOSED CUP: >110°C (230°F).


Products of Combustion: These products are carbon oxides (CO, CO2), sulfur oxides (SO2, SO3...).

Fire Hazards in Presence of Various Substances:Slightly flammable to flammable in presence of heat. Non-flammable in presence of shocks.

Explosion Hazards in Presence of Various Substances:Risks of explosion of the product in presence of mechanical impact: Not available. Slightly explosive in presence of openflames and sparks.


Special Remarks on Fire Hazards:When heated to decomposition it emits toxic fumes of Sulfur oxides, and Hydrogen Sulfide gas. As with most organic solids,fire is possible at elevated temperatures






p. 3

Precautions:Keep locked up.. Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate theresidue under a fume hood. Ground all equipment containing material. Do not breathe dust. Wear suitable protective clothing.In case of insufficient ventilation, wear suitable respiratory equipment. If you feel unwell, seek medical attention and showthe label when possible. Avoid contact with skin and eyes. Keep away from incompatibles such as oxidizing agents, reducingagents, alkalis.

Storage:Keep container tightly closed. Keep container in a cool, well-ventilated area. Refrigerate. Do not store above 6°C (42.8°F).










Molecular Weight: Not available.



Boiling Point: Not available.

Melting Point: 42°C (107.6°F) - 44 C









Dispersion Properties: Not available.

Solubility: Easily soluble in diethyl ether, acetone, ethanol

p. 4




Conditions of Instability: Excess heat, incompatible materials, dust generation

Incompatibility with various substances: Reactive with oxidizing agents, reducing agents, alkalis.

Corrosivity: Not available.

Special Remarks on Reactivity: Also incompatible with Alkali metals


Polymerization: Will not occur.


Routes of Entry: Inhalation. Ingestion.

Toxicity to Animals:LD50: Not available. LC50: Not available.

Chronic Effects on Humans:MUTAGENIC EFFECTS: Mutagenic for bacteria and/or yeast. May cause damage to the following organs: central nervoussystem (CNS).

Other Toxic Effects on Humans: Hazardous in case of skin contact (irritant), of ingestion, of inhalation (lung irritant).

Special Remarks on Toxicity to Animals:Lethal Dose/Conc 50% Kill: LD50 [Mouse] - Route: Intraperitoneal; Dose: 169 mg/kg LD50 [Mouse] - Route: Subcutaneous;Dose: 333 mg/kg LD50 [Mouse] - Route: Intravenous; Dose: 94 mg/kg


Special Remarks on other Toxic Effects on Humans:Acute Potential Health Effects: Skin: Causes skin irritation. Eyes: Causes eye irritation. Inhalation: Causes respiratory tractand mucouso membrane irritation. Ingestion: Can cause gastrointestinal tract irritation with nausea, and vomiting. May alsoaffect behavior/central nervous and cause CNS depression, convulsions, and headache. The toxicological properties of thissubstance have not been fully investigated.





Toxicity of the Products of Biodegradation: The product itself and its products of degradation are not toxic.



Waste Disposal:Waste must be disposed of in accordance with federal, state and local environmental control regulations.

p. 5






Federal and State Regulations: No products were found.

Other Regulations: EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.


WHMIS (Canada): Not controlled under WHMIS (Canada).

DSCL (EEC):R36/37/38- Irritating to eyes, respiratory system and skin. S24/25- Avoid contact with skin and eyes. S36/37/39- Wear suitableprotective clothing, gloves and eye/face protection.

HMIS (U.S.A.):

Health Hazard: 2

Fire Hazard: 1

Reactivity: 0



Health: 2

Flammability: 1

Reactivity: 0

Specific hazard:

Protective Equipment:Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Splash goggles.




Created: 10/09/2005 05:15 PM

Last Updated: 05/21/2013 12:00 PM


SAFETY DATA SHEET




Page 1 of 21




Product name Methanol EMPLURA®






CAS-No. 67-56-1








India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6

1.4 Emergency telephone Please contact the regional company representation in your country.

SAFETY DATA SHEET





Page 2 of 21

number




Flammable liquid, Category 2, H225



Acute toxicity, Category 3, Dermal, H311

Specific target organ toxicity - single exposure, Category 1, Eyes, H370


2.2 Label elements


Hazard pictograms

Signal word

Danger

Hazard statements

H225 Highly flammable liquid and vapour.

H301 + H311 + H331 Toxic if swallowed, in contact with skin or if inhaled.

H370 Causes damage to organs (Eyes).


Prevention

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No

smoking.

P240 Ground/bond container and receiving equipment.

P280 Wear protective gloves/ protective clothing.

SAFETY DATA SHEET





Page 3 of 21

Response



breathing.


Storage

P403 + P233 Store in a well-ventilated place. Keep container tightly closed.


Hazard pictograms

Signal word

Danger

Hazard statements




P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.


P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.


CAS-No. 67-56-1

2.3 Other hazards

None known.


3.1 Substance

Formula CH₃OH CH₄O (Hill)

EC-No. 200-659-6


SAFETY DATA SHEET





Page 4 of 21




Methanol (<= 100 % )


67-56-1 *)










3.2 Mixture

Not applicable



General advice


After inhalation: fresh air. Immediately call in physician. If breathing stops: immediately apply

artificial respiration, if necessary also oxygen.




SAFETY DATA SHEET





Page 5 of 21

After swallowing: fresh air. Make victim drink ethanol (e.g. 1 drinking glass of a 40% alcoholic

beverage). Call a doctor immediately (mention methanol ingestion). Only in exceptional cases, if

no medical care is available within one hour, induce vomiting (only in fully conscious persons)

and make victim drink ethanol again (approx. 0.3 ml of a 40% alcoholic beverage/kg body

weight/hour).


irritant effects, Drowsiness, Dizziness, narcosis, agitation, spasms, inebriation, Nausea,

Vomiting, Headache, blindness, Impairment of vision, Coma

Drying-out effect resulting in rough and chapped skin.






Foam, Carbon dioxide (CO2), Dry powder, Water




Combustible.


Forms explosive mixtures with air at ambient temperatures.

Pay attention to flashback.






SAFETY DATA SHEET





Page 6 of 21

Further information

Remove container from danger zone and cool with water. Suppress (knock down)

gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating

surface water or the ground water system.



Advice for non-emergency personnel: Do not breathe vapours, aerosols. Avoid substance

contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the

danger area, observe emergency procedures, consult an expert.




Do not let product enter drains. Risk of explosion.



sections 7 and 10). Take up carefully with liquid-absorbent material (e.g. Chemizorb®). Dispose

of properly. Clean up affected area.






Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.


Advice on protection against fire and explosion

Keep away from open flames, hot surfaces and sources of ignition. Take precautionary

measures against static discharge.

SAFETY DATA SHEET





Page 7 of 21

Hygiene measures




Storage conditions

Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and

sources of ignition. Keep locked up or in an area accessible only to qualified or authorised

persons.






Methanol (67-56-1)

IN OEL Skin designation: Can be absorbed through the skin.

Short Term Exposure

Limit (STEL):

250 ppm

310 mg/m³

Time Weighted Average

(TWA):

200 ppm

260 mg/m³





See section 7.1.

SAFETY DATA SHEET





Page 8 of 21





Eye/face protection

Safety glasses

Hand protection

full contact:

Glove material: butyl-rubber



splash contact:

Glove material: Viton (R)




89/686/EEC and the related standard EN374, for example KCL 898 Butoject® (full contact), KCL

890 Vitoject® (splash contact).








Flame retardant antistatic protective clothing.


required when vapours/aerosols are generated.

Recommended Filter type: Filter AX (EN 371)




SAFETY DATA SHEET





Page 9 of 21



Risk of explosion.



Form liquid

Colour colourless

Odour characteristic

pungent

Odour Threshold 10 - 20000 ppm


Melting point -98 °C

Boiling point/boiling range 64.5 °C

at 1,013 hPa

Flash point 9.7 °C

Method: Tested according to Directive 92/69/EEC.

Evaporation rate 6.3

Reference substance: Diethylether

1.9

Reference substance: n-butyl acetate

SAFETY DATA SHEET





Page 10 of 21



Upper explosion limit 44 %(V)


at 20 °C

Relative vapour density 1.11

Density 0.792 g/cm3

at 20 °C


Water solubility completely miscible


octanol/water

log Pow: -0.77

(experimental)



Decomposition temperature Distillable in an undecomposed state at normal pressure.

Viscosity, dynamic 0.597 mPa.s

at 20 °C



9.2 Other data

SAFETY DATA SHEET





Page 11 of 21


at1,013 hPa

Method: DIN 51794

Minimum ignition energy 0.14 mJ

Conductivity < 1 µS/cm


10.1 Reactivity

Vapours may form explosive mixture with air.





Oxidizing agents, perchloric acid, perchlorates, salts of oxyhalogenic acids, chromium(VI) oxide,

halogen oxides, nitrogen oxides, nonmetallic oxides, chromosulfuric acid, chlorates, hydrides, zinc

diethyl, halogens, powdered magnesium, hydrogen peroxide, Nitric acid, sulphuric acid,

permanganic acid, sodium hypochlorite


acid halides, Acid anhydrides, Reducing agents, acids, Bromine, Chlorine, Chloroform,

magnesium, tetrachloromethane, CYANURIC CHLORIDE


Fluorine, Oxides of phosphorus, Raney-nickel


Alkaline earth metals, Alkali metals


Warming.


SAFETY DATA SHEET





Page 12 of 21

various plastics, magnesium, zinc alloys





Acute oral toxicity

LDLO human: 143 mg/kg

(RTECS)

Acute toxicity estimate: 100.1 mg/kg

Expert judgement



LC50 Rat: 131.25 mg/l; 4 h ; vapour

(ECHA)

Symptoms: Irritation symptoms in the respiratory tract.


LD50 Rabbit: ca. 17,100 mg/kg

(External MSDS)

Acute toxicity estimate : 300.1 mg/kg

Expert judgement

Skin irritation

Rabbit


(ECHA)


SAFETY DATA SHEET





Page 13 of 21

Eye irritation

Rabbit


(ECHA)

Irritations of mucous membranes

Sensitisation


Result: negative




Micronucleus test

Mouse

male and female

Intraperitoneal injection

Bone marrow

Result: negative



Ames test


Result: negative


In vitro mammalian cell gene mutation test

Result: negative


Carcinogenicity


SAFETY DATA SHEET





Page 14 of 21



Teratogenicity


CMR effects

Carcinogenicity:

Did not show carcinogenic effects in animal experiments.

Mutagenicity:

Based on available data the classification criteria are not met.

Teratogenicity:





Causes damage to organs.

Target Organs: Eyes



Repeated dose toxicity

Rat

male and female

Inhalation

vapour

28 d

daily

NOAEL: 6.66 mg/l


Subacute toxicity

Rat

male and female

Inhalation

SAFETY DATA SHEET





Page 15 of 21

365 d

daily

NOAEL: 0.13 mg/l

LOAEL: 1.3 mg/l


Aspiration hazard



Systemic effects:

acidosis, drop in blood pressure, agitation, spasms, inebriation, Dizziness, Drowsiness,

Headache, Impairment of vision, blindness, narcosis, Coma

Symptoms may be delayed.

Damage to:

Liver, Kidney, Cardiac, Irreversible damage of the optical nerve.




12.1 Toxicity

Toxicity to fish

flow-through test LC50 Lepomis macrochirus (Bluegill sunfish): 15,400 mg/l; 96 h

US-EPA


EC5 E.sulcatum: > 10,000 mg/l; 72 h

(Lit.)

EC50 Daphnia magna (Water flea): > 10,000 mg/l; 48 h

(IUCLID)

Toxicity to algae

static test EC50 Pseudokirchneriella subcapitata (green algae): ca. 22,000 mg/l; 96 h


SAFETY DATA SHEET





Page 16 of 21


EC5 Pseudomonas fluorescens: 6,600 mg/l; 16 h

(IUCLID)

static test IC50 activated sludge: > 1,000 mg/l; 3 h

Analytical monitoring: yes



NOEC Oryzias latipes (Orange-red killifish): 7,900 mg/l; 200 h

(External MSDS)


Biodegradability

99 %; 30 d



Biochemical Oxygen Demand (BOD)

600 - 1,120 mg/g (5 d)

(IUCLID)

Chemical Oxygen Demand (COD)

1,420 mg/g

(IUCLID)

Theoretical oxygen demand (ThOD)

1,500 mg/g

(Lit.)

Ratio BOD/ThBOD

BOD5 76 %

Closed Bottle test


SAFETY DATA SHEET





Page 17 of 21


log Pow: -0.77

(experimental)








Surface tension

22.6 mN/m

at 20 °C

Stability in water

2.2 yr

reaction with hydroxyl radicals (IUCLID)


SAFETY DATA SHEET





Page 18 of 21





the product itself.






14.2 Proper shipping name METHANOL

14.3 Class 3 (6.1)




user

yes

Tunnel restriction code D/E


Not relevant




14.3 Class 3 (6.1)



SAFETY DATA SHEET





Page 19 of 21


user

no




14.3 Class 3 (6.1)




user

yes

EmS F-E S-D


Not relevant




Storage class 3






H301 Toxic if swallowed.

H311 Toxic in contact with skin.

H331 Toxic if inhaled.

H370 Causes damage to organs.

SAFETY DATA SHEET





Page 20 of 21

Training advice


Labelling

Hazard pictograms

Signal word

Danger

Hazard statements





Prevention

P210 Keep away from heat/sparks/open flames/hot surfaces. No smoking.



Response



breathing.


Storage



SAFETY DATA SHEET





Page 21 of 21




SAFETY DATA SHEET




Page 1 of 19




Product name Acetic acid (glacial) 100% anhydrous for analysis EMSURE®







CAS-No. 64-19-7








India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6


number


SAFETY DATA SHEET






Page 2 of 19








2.2 Label elements


Hazard pictograms

Signal word

Danger

Hazard statements

H226 Flammable liquid and vapour.




Prevention

P210 Keep away from heat.


Response




SAFETY DATA SHEET






Page 3 of 19



Hazard pictograms

Signal word

Danger

Hazard statements








Contains: acetic acid

CAS-No. 64-19-7

2.3 Other hazards

None known.


3.1 Substance

Formula CH₃COOH C₂H₄O₂ (Hill)

EC-No. 200-580-7


SAFETY DATA SHEET






Page 4 of 19




acetic acid (<= 100 % )


64-19-7 *)








3.2 Mixture

Not applicable



General advice






contact lenses.




SAFETY DATA SHEET






Page 5 of 19

Irritation and corrosion, bronchitis, Shortness of breath, gastric spasms, Nausea, Vomiting,

Circulatory collapse, shock


Risk of blindness!






Water, Carbon dioxide (CO2), Foam, Dry powder




Combustible.


Forms explosive mixtures with air at elevated temperatures.



Acetic acid vapours





Further information


water from contaminating surface water or the ground water system. Remove container from

danger zone and cool with water.

SAFETY DATA SHEET






Page 6 of 19













Take up with liquid-absorbent and neutralising material (e.g. Chemizorb® H⁺, Merck Art. No.

101595). Dispose of properly. Clean up affected area.










Hygiene measures



SAFETY DATA SHEET






Page 7 of 19


Storage conditions

Keep away from heat and sources of ignition. Keep container tightly closed in a dry and well-

ventilated place.






acetic acid (64-19-7)

IN OEL Short Term Exposure

Limit (STEL):

15 ppm

37 mg/m³

Time Weighted Average

(TWA):

10 ppm

25 mg/m³





See section 7.1.





SAFETY DATA SHEET






Page 8 of 19

Eye/face protection


Hand protection

full contact:




splash contact:

Glove material: natural latex





706 Lapren® (splash contact).











Recommended Filter type: filter E-(P2)




SAFETY DATA SHEET






Page 9 of 19



Risk of explosion.



Form liquid

Colour colourless

Odour stinging

Odour Threshold 0.2 - 100.1 ppm

pH 2.5

at 50 g/l

20 °C


Boiling point/boiling range 116 - 118 °C

at 1,013 hPa

Flash point 39 °C

Method: c.c.


Flammability (solid, gas) Not applicable

Lower explosion limit 4 %(V)


SAFETY DATA SHEET






Page 10 of 19

Vapour pressure 15.4 hPa

at 20 °C


Density 1.05 g/cm3

at 20 °C


Water solubility 602.9 g/l

at 25 °C


octanol/water

log Pow: -0.17 (25 °C)

(experimental)

(ECHA) Bioaccumulation is not expected.




at 20 °C



9.2 Other data


Viscosity, kinematic 1.17 mm2/s

at 20 °C

SAFETY DATA SHEET






Page 11 of 19



10.1 Reactivity

Vapour/air-mixtures are explosive at intense warming.





peroxi compounds, perchloric acid, fuming sulfuric acid, phosphorus halides, hydrogen peroxide,

chromium(VI) oxide, potassium permanganate, Peroxides, Strong oxidizing agents


Metals, Iron, Zinc, magnesium, Mild steel

Possible formation of:

Hydrogen


strong alkalis, anhydrides, Aldehydes, alkali hydroxides, nonmetallic halides, ethanolamine,

Acetaldehyde, Alcohols, halogen-halogen compounds, chlorosulfonic acid, chromosulfuric acid,

Potassium hydroxide, Nitric acid


Temperatures < 17 °C.

Heating.


various metals



SAFETY DATA SHEET






Page 12 of 19



Acute oral toxicity


(RTECS)


of the oesophagus and the stomach., Nausea, Vomiting, Risk of aspiration upon vomiting.,

Pulmonary failure possible after aspiration of vomit.


LCLO Rat: 39.95 mg/l; 4 h

(RTECS)

Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of

respiratory tract, Pneumonia, bronchitis, Inhalation may lead to the formation of oedemas in the

respiratory tract., Symptoms may be delayed.



Skin irritation

Rabbit


(IUCLID)


Eye irritation

Rabbit


(IUCLID)

SAFETY DATA SHEET






Page 13 of 19


Risk of blindness!


Sensitisation




Ames test


Result: negative


Mutagenicity (mammal cell test): chromosome aberration.

Result: negative


Carcinogenicity




Teratogenicity

Did not show teratogenic effects in animal experiments. (IUCLID)





Aspiration hazard



Systemic effects:

Shortness of breath, gastric spasms, shock, Circulatory collapse, acidosis

SAFETY DATA SHEET






Page 14 of 19

Possible damages:

Damage to:

Kidney




12.1 Toxicity

Toxicity to fish

semi-static test LC50 Oncorhynchus mykiss (rainbow trout): > 300.8 mg/l; 96 h



EC5 E.sulcatum: 78 mg/l; 72 h

neutral (maximum permissible toxic concentration) (Lit.)

EC50 Daphnia magna (Water flea): 47 mg/l; 24 h

(Lit.)

Toxicity to algae

IC5 Scenedesmus quadricauda (Green algae): 4,000 mg/l; 16 h

(maximum permissible toxic concentration) (Lit.)


EC5 Pseudomonas putida: 2,850 mg/l; 16 h

neutral (maximum permissible toxic concentration) (Lit.)

microtox test EC50 Photobacterium phosphoreum: 11 mg/l; 15 min

(IUCLID)


Biodegradability

99 %; 30 d


(HSDB)


SAFETY DATA SHEET






Page 15 of 19

95 %; 5 d

OECD Test Guideline 302B

Readily eliminated from water

Biochemical Oxygen Demand (BOD)

880 mg/g (5 d)

(Lit.)

Ratio BOD/ThBOD

BOD5 76 %

(IUCLID)



log Pow: -0.17 (25 °C)

(experimental)

(ECHA) Bioaccumulation is not expected.








Biological effects:

Harmful effect due to pH shift. Caustic even in diluted form.


SAFETY DATA SHEET






Page 16 of 19





the product itself.






14.2 Proper shipping name ACETIC ACID, GLACIAL

14.3 Class 8 (3)




user

yes



Not relevant




14.3 Class 8 (3)



SAFETY DATA SHEET






Page 17 of 19


user

no




14.3 Class 8 (3)




user

yes

EmS F-E S-C


Not relevant




Storage class 3








SAFETY DATA SHEET






Page 18 of 19

Training advice


Labelling

Hazard pictograms

Signal word

Danger

Hazard statements





Prevention

P210 Keep away from heat.


Response





Contains: acetic acid



SAFETY DATA SHEET






Page 19 of 19



SAFETY DATA SHEETCreation Date 21-Sep-2009 Revision Date 18-Jan-2018 Revision Number 4

1. IdentificationProduct Name Trifluoroacetic acid

Cat No. : A116-05AMP; A116-1AMP; A116-10X1AMP; A116-2AMP; A116-50

CAS-No 76-05-1Synonyms TFA; Trifluoroethanoic acid; Perfluoroacetic acid

Recommended Use Laboratory chemicals.Uses advised against Not for food, drug, pesticide or biocidal product use

Details of the supplier of the safety data sheet

Emergency Telephone Number CHEMTRECÒ, Inside the USA: 800-424-9300CHEMTRECÒ, Outside the USA: 001-703-527-3887

2. Hazard(s) identificationClassification This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Label Elements

Signal WordDanger

Hazard StatementsMay be corrosive to metalsHarmful if inhaledCauses severe skin burns and eye damageMay cause respiratory irritationMay cause drowsiness or dizzinessMay cause damage to organs through prolonged or repeated exposure

Company Fisher ScientificOne Reagent LaneFair Lawn, NJ 07410Tel: (201) 796-7100

Acute Inhalation Toxicity - Vapors Category 4Skin Corrosion/irritation Category 1 ASerious Eye Damage/Eye Irritation Category 1Specific target organ toxicity (single exposure) Category 3Target Organs - Respiratory system, Central nervous system (CNS).Specific target organ toxicity - (repeated exposure) Category 2Target Organs - Kidney, Liver.

Corrosive to metals Category 1

______________________________________________________________________________________________

Page 1 / 7

______________________________________________________________________________________________Trifluoroacetic acid Revision Date 18-Jan-2018

Precautionary StatementsPreventionUse only outdoors or in a well-ventilated areaDo not breathe dust/fume/gas/mist/vapors/sprayWash face, hands and any exposed skin thoroughly after handlingWear protective gloves/protective clothing/eye protection/face protectionResponseImmediately call a POISON CENTER or doctor/physicianInhalationIF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathingSkinIF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/showerWash contaminated clothing before reuseEyesIF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsingIngestionIF SWALLOWED: Rinse mouth. DO NOT induce vomitingStorageStore locked upStore in a well-ventilated place. Keep container tightly closedDisposalDispose of contents/container to an approved waste disposal plantHazards not otherwise classified (HNOC) Harmful to aquatic life with long lasting effects

3. Composition/Information on Ingredients

Component CAS-No Weight %Trifluoroacetic acid 76-05-1 >95

4. First-aid measures

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.Immediate medical attention is required.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Immediate medicalattention is required.

Inhalation Move to fresh air. Do not use mouth-to-mouth method if victim ingested or inhaled thesubstance; give artificial respiration with the aid of a pocket mask equipped with a one-wayvalve or other proper respiratory medical device. Immediate medical attention is required. Ifnot breathing, give artificial respiration.

Ingestion Do not induce vomiting. Call a physician or Poison Control Center immediately.

Most important symptoms andeffects

Causes burns by all exposure routes. Product is a corrosive material. Use of gastriclavage or emesis is contraindicated. Possible perforation of stomach or esophagus should

______________________________________________________________________________________________

Page 2 / 7


be investigated: Ingestion causes severe swelling, severe damage to the delicate tissueand danger of perforation

Notes to Physician Treat symptomatically

5. Fire-fighting measuresSuitable Extinguishing Media CO 2, dry chemical, dry sand, alcohol-resistant foam.

Unsuitable Extinguishing Media No information available

Flash Point No information availableMethod - No information available

Autoignition Temperature No information availableExplosion Limits

Upper No data availableLower No data availableSensitivity to Mechanical Impact No information availableSensitivity to Static Discharge No information available

Specific Hazards Arising from the ChemicalCorrosive Material. Causes severe burns by all exposure routes.

Hazardous Combustion ProductsCarbon monoxide (CO) Carbon dioxide (CO2) Hydrogen fluorideProtective Equipment and Precautions for FirefightersAs in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and fullprotective gear. Thermal decomposition can lead to release of irritating gases and vapors.

NFPA

6. Accidental release measuresPersonal Precautions Use personal protective equipment. Ensure adequate ventilation. Evacuate personnel to

safe areas. Keep people away from and upwind of spill/leak.Environmental Precautions Should not be released into the environment. See Section 12 for additional ecological

information. Do not flush into surface water or sanitary sewer system.

Methods for Containment and CleanUp

Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

7. Handling and storageHandling Use only under a chemical fume hood. Wear personal protective equipment. Do not get in

eyes, on skin, or on clothing. Do not breathe vapors/dust. Do not ingest.

Storage Keep containers tightly closed in a dry, cool and well-ventilated place. Corrosives area. Donot store in metal containers.

8. Exposure controls / personal protectionExposure Guidelines This product does not contain any hazardous materials with occupational exposure

limitsestablished by the region specific regulatory bodies.

Health3

Flammability0

Instability0

Physical hazardsN/A

Engineering Measures Use only under a chemical fume hood. Ensure that eyewash stations and safety showersare close to the workstation location.

______________________________________________________________________________________________

Page 3 / 7


9. Physical and chemical propertiesPhysical State LiquidAppearance Clear, ColorlessOdor pungentOdor Threshold No information availablepH 0.45 100 g/L aq.solMelting Point/Range -15 °C / 5 °FBoiling Point/Range 72 °C / 161.6 °F @ 760 mmHgFlash Point No information availableEvaporation Rate No information availableFlammability (solid,gas) Not applicableFlammability or explosive limits

Upper No data availableLower No data available

Vapor Pressure 107 mbar @ 25 °CVapor Density 3.9Specific Gravity 1.535Solubility Miscible with waterPartition coefficient; n-octanol/water No data availableAutoignition Temperature No information availableDecomposition Temperature No information availableViscosity 0.813 cP at 25 °CMolecular Formula C2 H F3 O2Molecular Weight 114.02

10. Stability and reactivity

Reactive Hazard None known, based on information available

Stability Hygroscopic.

Conditions to Avoid Incompatible products. Exposure to moist air or water. Exposure to light. Excess heat.

Incompatible Materials Strong oxidizing agents, Reducing agents, Acids, Strong bases, Metals, Amines

Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2), Hydrogen fluoride

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions None under normal processing.

11. Toxicological informationAcute Toxicity

Product Information

Personal Protective Equipment

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described byOSHA's eye and face protection regulations in 29 CFR 1910.133 or European StandardEN166.

Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.

Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European StandardEN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator ifexposure limits are exceeded or if irritation or other symptoms are experienced.

Hygiene Measures

______________________________________________________________________________________________

Page 4 / 7



Component InformationComponent LD50 Oral LD50 Dermal LC50 Inhalation

Trifluoroacetic acid 200-400 mg/kg (rat) Not listed 10 mg/L/2h (rat)Toxicologically SynergisticProducts

No information available

Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation Causes severe burns by all exposure routes

Sensitization No information available

Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS-No IARC NTP ACGIH OSHA MexicoTrifluoroacetic acid 76-05-1 Not listed Not listed Not listed Not listed Not listed

Mutagenic Effects Not mutagenic in AMES Test

Reproductive Effects No information available.

Developmental Effects No information available.

Teratogenicity No information available.

STOT - single exposure Respiratory system Central nervous system (CNS)STOT - repeated exposure Kidney Liver

Aspiration hazard No information available

Symptoms / effects,both acute anddelayed

Product is a corrosive material. Use of gastric lavage or emesis is contraindicated.Possible perforation of stomach or esophagus should be investigated: Ingestion causessevere swelling, severe damage to the delicate tissue and danger of perforation

Endocrine Disruptor Information No information available

Other Adverse Effects The toxicological properties have not been fully investigated.

12. Ecological informationEcotoxicity Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Do not empty into drains. Theproduct contains following substances which are hazardous for the environment.

Component Freshwater Algae Freshwater Fish Microtox Water FleaTrifluoroacetic acid Not listed Zebrafish: LC50: >1000

mg/L/96hNot listed daphnia: EC50: 55 mg/L/24h

Persistence and Degradability Persistence is unlikely based on information available.

Bioaccumulation/ Accumulation No information available.

Mobility Will likely be mobile in the environment due to its volatility.

Component log PowTrifluoroacetic acid -2.1

13. Disposal considerationsWaste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a

hazardous waste. Chemical waste generators must also consult local, regional, andnational hazardous waste regulations to ensure complete and accurate classification.

______________________________________________________________________________________________

Page 5 / 7

14. Transport information


DOT UN-No UN2699Proper Shipping Name TRIFLUOROACETIC ACIDHazard Class 8Packing Group I

TDG UN-No UN2699Proper Shipping Name TRIFLUOROACETIC ACIDHazard Class 8Packing Group I

IATA UN-No UN2699Proper Shipping Name TRIFLUOROACETIC ACIDHazard Class 8Packing Group I

IMDG/IMO UN-No UN2699Proper Shipping Name TRIFLUOROACETIC ACIDHazard Class 8Packing Group I

15. Regulatory information

All of the components in the product are on the following Inventory lists:

International Inventories

Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS IECSC KECLTrifluoroacetic acid X X - 200-929-3 - X X X X KE-3423

3X

Legend:X - ListedE - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA.F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA.N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designatedpolymer made with any free-radical initiator regardless of the amount used.P - Indicates a commenced PMN substanceR - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA.S - Indicates a substance that is identified in a proposed or final Significant New Use RuleT - Indicates a substance that is the subject of a Section 4 test rule under TSCA.XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data BaseProduction and Site Reports (40 CFR 710(B).Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater.Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactantsthat comprises one of the eligibility criteria for the exemption rule.

U.S. Federal Regulations

TSCA 12(b) Not applicable

SARA 313 Not applicable

SARA 311/312 Hazard Categories See section 2 for more information

CWA (Clean Water Act) Not applicable

Clean Air Act Not applicable

OSHA Occupational Safety and Health AdministrationNot applicable

______________________________________________________________________________________________

Page 6 / 7


CERCLA Not applicable

California Proposition 65 This product does not contain any Proposition 65 chemicals

U.S. State Right-to-KnowRegulations

Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island

Trifluoroacetic acid - X - - -

U.S. Department of Transportation

Reportable Quantity (RQ): NDOT Marine Pollutant NDOT Severe Marine Pollutant N

U.S. Department of Homeland SecurityThis product does not contain any DHS chemicals.

Other International Regulations

Mexico - Grade No information available

16. Other informationPrepared By Regulatory Affairs

Thermo Fisher ScientificEmail: [email protected]

Creation Date 21-Sep-2009Revision Date 18-Jan-2018Print Date 18-Jan-2018Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard

replacing the current legislation under 29 CFR 1910.1200 to align with the GloballyHarmonized System of Classification and Labeling of Chemicals (GHS).

DisclaimerThe information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at thedate of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,transportation, disposal and release and is not to be considered a warranty or quality specification. The informationrelates only to the specific material designated and may not be valid for such material used in combination with any othermaterials or in any process, unless specified in the text

End of SDS

______________________________________________________________________________________________

Page 7 / 7

SAFETY DATA SHEET




Page 1 of 17




Product name Acetonitrile for DNA synthesis (≤ 30 ppm H₂O)






CAS-No. 75-05-8








India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6


number





SAFETY DATA SHEET





Page 2 of 17




Acute toxicity, Category 4, Dermal, H312

Eye irritation, Category 2, H319


2.2 Label elements


Hazard pictograms

Signal word

Danger

Hazard statements


H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled

H319 Causes serious eye irritation.


Prevention



Response




Storage



Hazard pictograms

SAFETY DATA SHEET





Page 3 of 17

Signal word

Danger

CAS-No. 75-05-8

2.3 Other hazards

None known.


3.1 Substance

Formula CH₃CN C₂H₃N (Hill)

EC-No. 200-835-2



Chemical Name (Concentration)


Acetonitrile (<= 100 % )


75-05-8 *)










3.2 Mixture

Not applicable



SAFETY DATA SHEET





Page 4 of 17

After inhalation: fresh air. If breathing stops: mouth-to-mouth breathing or artificial respiration.

Oxygen if necessary. Immediately call in physician.





physician.


irritant effects, Nausea, Vomiting, Convulsions, Shortness of breath, Unconsciousness,

respiratory arrest, cardiac arrest

May cause headache and dizziness.

The following applies to cyanogen compounds/ nitriles in general: utmost caution! Release of

hydrocyanic acid is possible - blockade of cellular respiration. Cardiovascular disorders,

dyspnoea, unconsciousness.










Combustible.






nitrogen oxides, Hydrogen cyanide (hydrocyanic acid)


SAFETY DATA SHEET





Page 5 of 17




Further information

Remove container from danger zone and cool with water. Suppress (knock down)

gases/vapours/mists with a water spray jet. Prevent fire extinguishing water from contaminating

surface water or the ground water system.




contact. Keep away from heat and sources of ignition. Ensure adequate ventilation. Evacuate the





Do not empty into drains. Risk of explosion.




Take up with liquid-absorbent material (e.g. Chemizorb® ). Dispose of properly. Clean up

affected area.








SAFETY DATA SHEET





Page 6 of 17




Hygiene measures




Storage conditions

Keep away from heat and sources of ignition. Keep container tightly closed in a dry and well-

ventilated place.











See section 7.1.





Eye/face protection

Safety glasses

SAFETY DATA SHEET





Page 7 of 17

Hand protection

full contact:




splash contact:

Glove material: polychloroprene





720 Camapren® (splash contact).











Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic compounds






Risk of explosion.



SAFETY DATA SHEET





Page 8 of 17

Form liquid

Colour colourless

Odour ether-like

Odour Threshold 39.8 ppm


Melting point -45.7 °C

Boiling point/boiling range 81.6 °C

at 1,013 hPa

Flash point 2 °C

Method: c.c.




Upper explosion limit 17 %(V)


at 20 °C


Density 0.786 g/cm3

at 20 °C



soluble

SAFETY DATA SHEET





Page 9 of 17


octanol/water

log Pow: -0.34

(IUCLID) Bioaccumulation is not expected.




at 25 °C



9.2 Other data



10.1 Reactivity



heat-sensitive

Distillable in an undecomposed state at normal pressure.



Strong bases, strong reducing agents


nitrates, perchlorates, perchloric acid

conc. sulfuric acid, with, Heat


Oxidizing agents, Nitric acid

nitrogen dioxide, with, Catalyst

SAFETY DATA SHEET





Page 10 of 17


Acids


Warming.


rubber, various plastics





Acute oral toxicity

LD50 Mouse: 617 mg/kg







Skin irritation

Rabbit



Eye irritation

Rabbit

Result: Eye irritation


Causes serious eye irritation.

SAFETY DATA SHEET





Page 11 of 17

Sensitisation

Buehler Test Guinea pig

Result: negative





Mouse

male and female

i.p.

Result: negative



Ames test


Result: negative

(External MSDS)


Mouse lymphoma test

Result: negative


Carcinogenicity




Teratogenicity


SAFETY DATA SHEET





Page 12 of 17

CMR effects

Carcinogenicity:


Mutagenicity:


Teratogenicity:





The substance or mixture is not classified as specific target organ toxicant, single exposure.


The substance or mixture is not classified as specific target organ toxicant, repeated exposure.

Aspiration hazard



After absorption:

Systemic effects:

Shortness of breath, Headache, Dizziness, Nausea, Convulsions, Unconsciousness, respiratory

arrest, cardiac arrest

Symptoms may be delayed.

The following applies to cyanogen compounds/ nitriles in general: utmost caution! Release of

hydrocyanic acid is possible - blockade of cellular respiration. Cardiovascular disorders,

dyspnoea, unconsciousness.




12.1 Toxicity

Toxicity to fish

semi-static test LC50 Oryzias latipes (Orange-red killifish): > 100 mg/l; 96 h


SAFETY DATA SHEET





Page 13 of 17


semi-static test EC50 Daphnia magna (Water flea): > 1,000 mg/l; 48 h


semi-static test NOEC Daphnia magna (Water flea): 960 mg/l; 21 d


Toxicity to algae

static test EC50 Pseudokirchneriella subcapitata (green algae): > 1,000 mg/l; 72 h


static test NOEC Pseudokirchneriella subcapitata (green algae): > 1,000 mg/l; 72 h


IC5 Scenedesmus quadricauda (Green algae): 7,300 mg/l; 8 d

(IUCLID) (maximum permissible toxic concentration)


EC5 Pseudomonas putida: 680 mg/l; 16 h

(IUCLID) (maximum permissible toxic concentration)


Biodegradability

70 %; 21 d





log Pow: -0.34


Bioaccumulation

Bioconcentration factor (BCF): 0.3

Lepomis macrochirus (Bluegill sunfish)

Does not significantly accumulate in organisms.

Information taken from reference works and the literature.


SAFETY DATA SHEET





Page 14 of 17

Distribution among environmental compartments

Adsorption/Soil

log Koc: 1.21

Mobile in soils (Lit.)





Stability in water

DT50

> 9,999 d

at pH: 7

(calculated) Hydrolyses slowly.


Biological effects:

Hazard for drinking water supplies.


SAFETY DATA SHEET





Page 15 of 17





the product itself.






14.2 Proper shipping name ACETONITRILE

14.3 Class 3




user

yes



Not relevant




14.3 Class 3




user

no


SAFETY DATA SHEET





Page 16 of 17



14.3 Class 3




user

yes

EmS F-E S-D


Not relevant




Storage class 3







H312 Harmful in contact with skin.



Training advice


SAFETY DATA SHEET





Page 17 of 17

Labelling

Hazard pictograms

Signal word

Danger

Hazard statements


H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled



Prevention



Response




Storage






Safety Data Sheet

Issue Date: October 2013 Page 1 of 8Product: Labtech Absolute Alcohol

Absolute Alcohol

Section 1: Identification of the material and supplier

Product name: Absolute Alcohol (Ethanol)Other names: Ethyl Alcohol, Undenatured Ethanol, Absolute Alcohol, EthanolProduct Codes/Trade Names: EL, EL95, EL100, AA100HG

Recommended use: Histology, Cytology, General laboratory solvent, ReagentApplicable in: AustraliaSupplier: Labtech Service & SuppliesAddress: PO Box 453, Windsor NSW 2756Telephone: 02 8064 2333Email address: [email protected] site: www.labtech.com.auFacsimile: 02 8064 7813Emergency phone number: 000 Fire Brigade and Police (available in Australia only)

1800 774 557 Transpacific Emergency Response (available in Australiaonly)

Poisons Information Centre: 13 11 26 (available in Australia only)

This Safety Data Sheet (SDS) is issued by the Supplier in accordance with National Standards and Guidelines from SafeWork Australia (SWA – formerly ASCC/NOHSC). The information in it must not be altered, deleted or added to. The Supplierwill not accept any responsibility for any changes made to its SDS by any other person or organization. The Supplier willissue a new SDS when there is a change in product specifications and/or Standards, Codes, Guidelines, or Regulations.

Section 2: Hazard identification

Statement of hazardous nature: Classified as Hazardous according to the Approved Criteria For ClassifyingHazardous Substances [NOHSC:1008] 3rd Edition.Ethanol is classified as Dangerous Goods according to the Australian Code for the Transport of DangerousGoods by Road and Rail.

Risk Phrases Safety PhrasesR11 - Highly flammable.R20/22 - Harmful by inhalation and if swallowed.R36/38 - Irritating to eyes and skin.R66 - Repeated exposure may cause skin drynessand cracking.

S7/9 - Keep container tightly closed and in a wellventilated place.S16 - Keep away from sources of ignition - Nosmoking.S23 - Do not breathe vapour.S24/25 - Avoid contact with skin and eyes.S29 - Do not empty into drains.S33 - Take precautionary measures against staticdischarges.S36/37/39 - Wear suitable protective clothing/glovesand eye/face protection.S45 - In case of accident or if you feel unwell seekmedical advice immediately (show the labelwhenever possible).

Safety Data Sheet


Section 3: Composition / Information on ingredients

Chemical Name: Synonyms Proportion: CAS Number:

Ethyl AlcoholWater

Ethanol_

70 - 100%0 - 35% by wt

64-17-57732-18-5

Section 4: First aid measures

If there are signs of drunkenness (intoxication or inebriation) then serious health effects may follow(depending on the amount swallowed or inhaled).Immediate medical attention should be sought and the affected person transferred and accompanied to thecare of a doctor or hospital. Treat unconsciousness by placing the person in the coma position. Applyartificial respiration if breathing stops.

Swallowed: See above. If a minor amount has been accidentally swallowed, then, if conscious,dilute stomach contents by giving large amounts of water. Do not allow further workuntil fitness for duties is established.Do not attempt to induce vomiting or give anything by mouth to an unconscious person.Seek medical attention.

Eyes: Flush eye with water for a minimum of 15 minutes. Seek medical attention promptly ifirritation persists or any loss of vision occurs.

Skin: Immediately remove contaminated clothing. Wash skin with water. Laundercontaminated clothing before re-use.

Inhaled: Remove promptly to fresh air. If there are signs of drunkenness (intoxication orinebriation) or respiratory irritation, dizziness, nausea or headache occurs, seekimmediate medical attention.Treat unconsciousness by placing the person in the coma position. Apply artificialrespiration if breathing stops.

First Aid Facilities: Safety showers, eye wash stations and First Aid kits.

Advice to Doctor: Treat symptomatically and as for a narcotic substance.

Section 5: Fire fighting measures

Flammability: Highly flammable liquid. May form flammable mixtures with air. Burnswith a colourless flame. The vapour is heavier than air and may travelalong the ground; distant ignition and flash back are possible.Run off to sewers and drains may cause explosions. Isolate for at least800 metres in all directions if tanks or tankers are involved. The use ofcompressed air for filling, discharging, mixing or handling is prohibiteddue to the vapour hazard.All vessels must be earthed to avoid generation of static charges whenagitating or transferring solvents. Avoid all ignition sources. Intrinsicallysafe equipment is necessary in areas where this chemical is being used.

Suitable extinguishing media: Alcohol resistant foam is the preferred fire fighting medium but, if it is notavailable, fine water spray can be used. Water fog, fine water spray, drychemical or carbon dioxide may also be used.

Hazards from combustionproducts:

Burning can produce carbon monoxide and/or carbon dioxide.

Special protective precautionsand equipment for fire fighters:

Highly flammable liquid. Contain spill. Full fire kit and breathingapparatus is required.

Safety Data Sheet


Use water to cool exposed containers. Heating can cause expansion ordecomposition leading to violent rupture of containers. If safe to do so,remove containers from path of fire.Spills and leaks may be washed away with copious volumes of water,fog or spray. Prevent run-off from entering drains and watercourses.

HAZCHEM Code: ●2YE

Section 6: Accidental release measures

Emergency Procedure: In the event of a spill eliminate all sources of ignition and take measuresto prevent static discharge. No smoking. Use water spray to dispersevapour.Clear area of all personnel not directly involved in the clean up.All personnel involved in the containment and disposal procedures towear protective equipment as described in Section 8 to prevent skin andeye contamination and inhalation of vapours.Ventilate area well and ensure the atmosphere is safe before personnelreturn to the work area.

Containment Procedure: Stop and contain the spill for salvage or absorb in inert absorbentmaterial (e.g. soil, sand, vermiculite) for disposal by an approvedmethod. Prevent run-off into drains and waterways.If contamination of sewers or waterways has occurred, advise the localemergency services.

Clean Up Procedure: Wash the cleaned-up area with copious volumes of water to remove anytrace amounts of product. Spills can be converted to non-flammablemixtures by dilution with water.Non-returnable containers should be de-gassed prior to disposal.Dispose of all waste containers and used drums in accordance with localauthority guidelines.

Section 7: Handling and storage

Handling: Use in well ventilated areas away from all ignition sources. Intrinsicallysafe equipment only must be used in areas where this chemical is beingused.The use of compressed air for filling, discharging, mixing or handling isprohibited due to the vapour hazard. Containers must be earthed toavoid generation of static charges when agitating or transferring product.

Storage: Store in tightly closed containers in cool, dry, isolated and well-ventilatedareas away from heat, sources of ignition and incompatibles (see below).Store away from oxidizing agents. Keep containers closed at all times -check regularly for leaks.Do not eat, drink or smoke in areas of use or storage. Observe StateRegulations concerning the storage and handling of Dangerous Goods.Store with all precautions required for handling flammable liquids.The requirement of Australian Standard AS 1940 should be observed inaddition to AS 1020, AS 1076, AS 2380 and AS 3000.Empty containers retain residue (liquid and/or vapour) and aredangerous. Do not pressure cut, weld, braze, solder, drill, grind orexpose such containers to heat, flame, sparks, static electricity, or othersources of ignition.

Safety Data Sheet


Incompatibilities: Not to be stored with explosives (Class 1), flammable gases in bulk(Class 2.1), poisonous gases (Class 2.3), spontaneously combustiblesubstances (Class 4.2), oxidizing agents (Class 5.1), organic peroxides(Class 5.2), radioactive substances (Class 7).Exemptions may apply.

Section 8: Exposure controls / Personal protection

Exposure Standards: National Occupational Exposure Standard (NES), Safe WorkAustralia (formerly ASCC/NOHSC).

Ethanol:TWA - 1000 ppm (1880 mg/m3)

Notes: All occupational exposures to atmospheric contaminants should be keptto as low a level as is workable (practicable) and in all cases to below theNational Standard.These exposure standards are guides to be used in the control ofoccupational health hazards. These exposure standards should not beused as fine dividing lines between safe and dangerous concentrationsof chemicals. They are not a measure of relative toxicity.TWA (Time Weighted Average): the time-weighted average airborneconcentration over an eight-hour working day, for a five-day workingweek over an entire working life. According to current knowledge thisconcentration should neither impair the health of, nor cause unduediscomfort to, nearly all workers.

Biological Limit Values: No biological limit allocated.

ENGINEERING CONTROLS

Ventilation: Local exhaust ventilation and/or mechanical (general) exhaust isrecommended where vapours are likely to be generated. All suchequipment must be intrinsically safe.

Special Consideration forRepair &/or Maintenance ofContaminated Equipment:

Empty containers retain residue (liquid and/or vapour) and aredangerous. Do not pressure cut, weld, braze, solder, drill, grind orexpose such containers to heat, flame, sparks, static electricity, or othersources of ignition.Vapour is heavier than air - prevent concentration in hollows or sumps.Do not enter confined spaces where vapour may have collected. Keepcontainers closed when not in use.

PERSONAL PROTECTION

Personal Hygiene Protective clothing (gloves, coveralls, boots, etc.) should be worn toprevent skin contact. Always wash hands before smoking, eating,drinking or using the toilet.Wash contaminated clothing and other protective equipment beforestoring or re-using.

Skin Protection: Avoid skin contact by the use of approved chemical resistant gloves andaprons - PVC or Neoprene (AS 2161).

Eye Protection: Avoid eye contact by wearing chemical goggles with side-shields or face-shield (AS/NZS 1336) whenever exposed to vapour or mist or if there isa risk of splashing liquid in the eyes.Safety showers with eye-wash should be provided in all areas whereproduct is handled.

Safety Data Sheet


Respiratory Protection: None should be needed if engineering, storage and handling controls areadequate to ensure that atmospheric contamination is kept below theNational Standard.Where vapour concentrations are likely to approach or exceed theNational Standard, an approved organic vapour respirator (AS/NZS 1715and 1716) must be worn.In high vapour concentrations, or in suspected oxygen-deficientatmospheres such as empty vessels or confined spaces, use air-supplied hood.

Thermal Protection: None should be needed under normal circumstances.

Smoking & Other Dusts Smoking must be prohibited in all areas where this product is used. Seesafety information on flammability above.

Section 9: Physical and chemical properties

Appearance: Clear colourless liquid

Odour: Ethanol odour detectable at 80 - 100 ppm.

pH, at stated concentration: Not available

Vapour Pressure: 44 mm Hg @ 20°C

Vapour Density: 1.59 (air = 1)

Boiling Point/range (°C): 78°C (Ethanol)

Freezing/Melting Point (°C): -117°C

Solubility: Complete

Specific Gravity (H2O = 1): Approximately 0.8

FLAMMABLE MATERIALS

Flash Point: 13°C (Ethanol)

Flash Point Method: Abel closed cup

Flammable (Explosive)Limit - Upper:

19%

Flammable (Explosive)Limit - Lower:

3.5%

Autoignition Temperature: 392°C

ADDITIONAL PROPERTIES

Evaporation Rate: 253 (n-Butyl Acetate = 100)

Molecular Weight: Not available

Volatile OrganicCompounds Content(VOC):(as specified by the GreenBuilding Council of Australia)

100%

% Volatiles: 100%

Safety Data Sheet


Swallowed: Accidental swallowing is unlikely in the industrial setting. Swallowing ethanol cancause drunkenness or harmful central nervous system effects. The deliberateingestion of ethanol is a known occupational risk.As little as 50 - 100 ml intake in a shift in a 70kg worker may cause inebriation to thepoint where safety is impaired. Effects of a small intake may include excitation,euphoria, headache, dizziness, drowsiness, blurred vision, and fatigue.Drinking a large amount may lead to severe acute intoxication, tremors, convulsions,loss of consciousness, coma, respiratory arrest and death. Aspiration into lungs maycause pneumonitis.

Eyes: Vapours may irritate the eyes. Liquid and mists may severely irritate or damage theeyes.

Skin: Contact with skin may result in slight irritation and redness.

Inhaled: Vapour is moderately irritating to mucous membranes and respiratory tract. Inhalationof the vapour may result in drunkenness (see effects of swallowing above) orheadache, nausea, incoordination, narcosis (sleepiness) and vomiting.Early signs or symptoms may occur at airborne levels of 1000 to 5000 ppm.

Section 10: Stability and reactivity

Chemical Stability: Stable

Incompatible Materials: Will react with strong oxidizing agents.

Conditions to avoid: Heat, sparks, flame and build-up of static electricity.

Hazardous DecompositionProducts:

Burning can produce carbon monoxide and/or carbon dioxide.

Hazardous Reactions: Hazardous polymerisation will not occur.

Section 11: Toxicological information

Toxicological Data:LD50/oral/rat: 7060 mg/kg (literature data)LC50/inhalation/rat: 38 mg/l/10 h (literature data)

Health effects information is based on reported effects in use from overseas and Australian reports.

Effects: Acute

Effects: ChronicLong term exposure by swallowing or repeated inhalation may cause degenerative changes in the liver,kidneys, gastrointestinal tract and heart muscle.Prolonged or repeated contact and heavy skin contamination may cause skin drying and cracking and/ordermatitis with redness, itching, and swelling. This may lead to secondary infection.Ongoing or repeated exposures at high concentrations may cause central nervous system symptoms similarto "Acute: Swallowed" above. Deliberate inhalation of the vapour is a known occupational risk.

Safety Data Sheet


Additional NotesNasal and eye irritation may occur at concentrations below the exposure standard. Exposure to ethanol in thework setting adds to any intake from alcoholic drinks and any health effects caused by the total intake ofalcohol.In work areas where exposures in excess of the occupational exposure limits occur, then the following mayapply:- Persons with pre-existing liver impairment, skin and respiratory disorders may be at an increased risk.- Ethanol may cause adverse reproductive effects.- Absorption of some drugs may be affected causing adverse health effects.- Ingestion by pregnant women may cause serious effects in their newborn babies called "foetal alcoholsyndrome".The National Occupational Health & Safety Commission in Australia (NOHSC) does not classify ethanol as acarcinogen.IARC has evaluated ethanol as a carcinogen on the basis of effects of drinking alcoholic beverages, but thereis no known carcinogenic risk from occupational exposures.There is extensive toxicological and epidemiological information on the health effects of ingesting alcoholicdrinks containing ethanol.Inhalation at levels at or exceeding the Occupational Exposure limits or any deliberate ingestion is known tolead to health effects which may be evident in themselves or lead to impaired functioning and consequentsafety risks in the industrial setting.A blood alcohol level in excess of 0.05g/100ml is regarded as likely to impair functioning for tasks such asoperating machinery.

Section 12: Ecological information

Eco-toxicity: Toxicity to fish (acute): LC50/Golden ide/: >1000 mg/l/48 hToxicity to daphnia: EC50/Daphnia magna/: >1000 mg/l/24 h

Persistence andDegradability:

Degree of elimination: 94%Evaluation: biodegradable

Mobility: No data available

Section 13: Disposal considerations

Suitable for incineration by approved agent under controlled conditions if permitted by local authorities,otherwise disposal must be in accordance with local waste authority requirements.Product must be contained and not disposed to sewerage systems, drains or waterways. Advise flammablenature. Empty containers must be decontaminated by rinsing with water.

Section 14: Transport information

Proper Shipping Name: ETHANOLUN number: 1170DG Class: 3Subsidiary Risk 1: None AllocatedPackaging Group: IIHAZCHEM code: ●2YEMarine Pollutant: NoSpecial Precautions forUser:

Refer to incompatibilities in Section 7 and stability and reactivity information inSection 10.

ADDITIONAL TRANSPORT REQUIREMENTS: Nil

Safety Data Sheet


Section 15: Regulatory information

Poisons Schedule: Not Scheduled

Other: Nil

Section 16: Other information

Additional Information

Australian Standards References:AS 1020 The Control of Undesirable Static Electricity.AS 1076 Code of Practice for selection, installation and maintenance of electrical

apparatus and associated equipment for use in explosive atmospheres (otherthan mining applications) – Parts 1 to 13

AS/NZS 1336 Recommended Practices for Occupational Eye ProtectionAS/NZS 1715 Selection, Use and Maintenance of Respiratory Protective DevicesAS/NZS 1716 Respiratory Protective DevicesAS 1940 The Storage and Handling of Flammable and Combustible LiquidsAS 2161 Industrial Safety Gloves and Mittens (excluding electrical and medical gloves)AS 2380 Electrical equipment for explosive atmospheres – Explosion Protection

Techniques (Parts 1 to 9)AS 3000 Electrical installations (known as the Australian/New Zealand Wiring Rules).

Other References:NOHSC:2011 (2003) National Code of Practice for the Preparation of Material Safety Data Sheets 2nd

Edition, April 2003, National Occupational Health and Safety Commission.NOHSC; 2012 (1994) National Code of Practice for the Labelling of Workplace Substances, March 1994,

Australian Government Publishing Service, Canberra.NES National Occupational Exposure Standards for Workplace Atmospheric

Contaminants (NES), Safe Work Australia (formerly ASCC/NOHSC) 1995 asamended.

ADG Code Australian Dangerous Goods Code 7th Edition.

Authorisation

Authorised by: Quality & Technical ManagerDate of Issue: October 2013Review/Expiry Date: Sept 2018

Whilst the information contained in this document is based on data which, to the best of our knowledge, was accurate and reliable at the timeof preparation, no responsibility can be accepted by us for errors and omissions. The provision of this information should not be construed asa recommendation to use any of our products in violation of any patent rights or in breach of any statute or regulation. Users are advised tomake their own determination as to the suitability of this information in relation to their particular purposes and specific circumstances. Sincethe information contained in this document may be applied under conditions beyond our control, no responsibility can be accepted by us forany loss or damage caused by any person acting or refraining from action as a result of this information.

END OF SDS

SAFETY DATA SHEET

Document Type EGHS - EuropeGHS

Revision date 27-Jun-2016 Version 3

Section 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THECOMPANY/UNDERTAKING

1.1. Product identifier

Product name Enterokinase, light chainProduct No P8070

1.2. Relevant identified uses of the substance or mixture and uses advised against Recommended use This product is for research and development onlyUses advised against No information available

1.3. Details of the supplier of the safety data sheet Supplier Address New England BioLabs

240 County RoadIpswich, MA 01938USA

Company Phone Number 978-927-5054800-632-5227 (toll free)

Telefax 978-921-1350For further information, please contact

E-mail address [email protected]. Emergency telephone number

Emergency telephone 978-927-5054800-632-5227 (toll free)9:00am - 5:00pm Monday-Friday EST

Emergency telephone - §45 - (EC)1272/2008Europe 112

_____________________________________________________________________________________________

Specification No No information available

Product name Enterokinase, lightchain

Page 1 / 9 Product No P8070

_____________________________________________________________________________________________

Section 4: FIRST AID MEASURES

4.1. Description of first aid measures

General adviceImmediate medical attention is required. In case of accident or unwellness, seek medical advice immediately (show directions foruse or safety data sheet if possible). Remove from exposure, lie down. Do not breathe dust/fume/gas/mist/vapors/spray.

Eye contactRinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids. Consult a physician.

Skin contactWash skin with soap and water.

InhalationRemove to fresh air.

IngestionClean mouth with water and drink afterwards plenty of water.

4.2. Most important symptoms and effects, both acute and delayed No information available

4.3. Indication of any immediate medical attention and special treatment needed

Note to physiciansTreat symptomatically.

Section 2: HAZARDS IDENTIFICATION

2.1. Classification of the substance or mixture Regulation (EC) No 1272/2008This mixture is classified as not hazardous according to regulation (EC) 1272/2008 [GHS]

2.2. Label elements Product identifierThis mixture is classified as not hazardous according to regulation (EC) 1272/2008 [GHS]Signal wordNone

EUH210 - Safety data sheet available on request

2.3. Other hazards

Section 3: COMPOSITION/INFORMATION ON INGREDIENTS

3.1 Substances

Not applicable

3.2 Mixtures

Full text of H- and EUH-phrases: see section 16

_____________________________________________________________________________________________




_____________________________________________________________________________________________

Section 5: FIRE FIGHTING MEASURES

5.1. Extinguishing media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.

Unsuitable extinguishing mediaCAUTION: Use of water spray when fighting fire may be inefficient.

5.2. Special hazards arising from the substance or mixture No information available

5.3. Advice for firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and fullprotective gear.

Section 6: ACCIDENTAL RELEASE MEASURES

6.1. Personal precautions, protective equipment and emergency procedures

Personal precautionsEnsure adequate ventilation, especially in confined areas.

For emergency respondersUse personal protection recommended in Section 8.

6.2. Environmental precautions See Section 12 for additional Ecological Information.

6.3. Methods and material for containment and cleaning up

Methods for containmentPrevent further leakage or spillage if safe to do so.

Methods for cleaning upSoak up with inert absorbent material. Pick up and transfer to properly labeled containers. This material and its container must bedisposed of as hazardous waste.

Section 7: HANDLING AND STORAGE

7.1. Precautions for safe handling Handle in accordance with good industrial hygiene and safety practice.

7.2. Conditions for safe storage, including any incompatibilities

Storage temperatureRefer to www.neb.com for specific information.

Storage ConditionsKeep/store only in original container.

Incompatible materialsNone known based on information supplied.

7.3. Specific end use(s)

Risk management methods [RMM]The information required is contained in this Safety Data Sheet.

_____________________________________________________________________________________________




_____________________________________________________________________________________________

Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1. Control parameters

Exposure Limits This product, as supplied, does not contain any hazardous materials with occupationalexposure limits established by the region specific regulatory bodies

Derived No Effect Level (DNEL) No information available

Predicted No Effect Concentration(PNEC)


8.2. Exposure controls

Engineering controlsShowers. Eyewash stations.

Individual protection measures, such as personal protective equipmentEye/face protectionWear safety glasses with side shields (or goggles).

Skin and body protectionWear suitable protective clothing and gloves.

Respiratory protectionUse in well ventilated areas.

General hygiene considerationsHandle in accordance with good industrial hygiene and safety practice.

Environmental exposure controlsSee Section 12: ECOLOGICAL INFORMATION.

Section 9: PHYSICAL AND CHEMICAL PROPERTIES

Information on basic physical and chemical properties

Physical state LiquidAppearance ColorlessOdor MildOdor threshold No information available

Property Remarks • Method pH Refer to www.neb.com for specific informationMelting point / freezing point No information availableBoiling point / boiling range No information availableFlash point No information availableEvaporation rate No information availableFlammability (solid, gas) No information availableFlammability Limit in Air No information available

Upper flammability limitLower flammability limit

Vapor pressure No information availableVapor density No information availableRelative density No information availableSpecific gravity No information availableWater solubility No information availableSolubility in other solvents No information availablePartition coefficient No information availableAutoignition temperature No information available

_____________________________________________________________________________________________




_____________________________________________________________________________________________

Other information

Section 10: STABILITY AND REACTIVITY

10.1. Reactivity

10.2. Chemical stability Stable under normal conditions.

10.3. Possibility of hazardous reactions Can react briskly with oxidizers - danger of explosion.

10.4. Conditions to avoid Incompatible materials. Ignition sources. Heat.

10.5. Incompatible materials Strong oxidizing agents.

10.6. Hazardous decomposition products Thermal decomposition can lead to release of irritating and toxic gases and vapors. Carbon monoxide. Carbon dioxide (CO2).

Section 11: TOXICOLOGICAL INFORMATION

11.1. Information on toxicological effects

Acute toxicity

Product informationProduct does not present an acute toxicity hazard based on known or supplied information.

InhalationAvoid breathing vapors or mistsMay cause irritation of respiratory tract

Eye contactRednessMay cause slight irritation

Skin contactProlonged contact may cause redness and irritationRepeated exposure may cause skin dryness or cracking

IngestionMay cause drowsiness or dizzinessIngestion may cause gastrointestinal irritation, nausea, vomiting and diarrheaSymptoms include burning sensation, coughing, wheezing, shortness of breath, headache, nausea, and vomiting

Unknown acute toxicity 51.5 % of the mixture consists of ingredient(s) of unknown toxicity

Decomposition temperature No information availableKinematic viscosity No information availableDynamic viscosity No information availableExplosive properties No information availableOxidizing properties No information available

Softening point No information availableMolecular weight No information availableVOC content (%) No information availableDensity No information availableBulk density No information available

No data available.

_____________________________________________________________________________________________




_____________________________________________________________________________________________

The following values are calculated based on chapter 3.1 of the GHS documentATEmix (oral) 22,892.00 mg/kgATEmix (dermal) 19,531.00 mg/kgATEmix (inhalation-vapor) 860.00 mg/l

Skin corrosion/irritation MildSerious eye damage/eye irritation MildSensitization Not applicableGerm cell mutagenicity Not applicable

Carcinogenicity No information available

Reproductive toxicity No information availableDevelopmental toxicity No information availableTeratogenicity No information availableSTOT - single exposure No information availableSTOT - repeated exposure No information availableNeurological effects No information availableTarget organ effects Eyes, Kidneys, Respiratory system, Skin.Other adverse effects No information availableSymptoms No information availableAspiration hazard No information available

Section 12: ECOLOGICAL INFORMATION

12.1. Toxicity

0.3 % of the mixture consists of component(s) of unknown hazards to the aquatic environment

12.2. Persistence and degradability No information available

12.3. Bioaccumulative potential No information available

12.4. Mobility in soil No information available

12.5. Results of PBT and vPvB assessment No information available

12.6. Other adverse effects

Other adverse effectsNo information available

Endocrine disruptor informationNo information available

OzoneNo information available

_____________________________________________________________________________________________




_____________________________________________________________________________________________

Section 13: DISPOSAL CONSIDERATIONS

13.1. Waste treatment methods

Relevant InformationKeep out of drains, sewers, ditches and waterways.

Waste from Residues/Unused ProductsDisposal should be in accordance with applicable regional, national and local laws and regulations. Send to a licensed recycler,reclaimer or incinerator.

Contaminated packagingEmpty containers must be tripled rinsed prior to disposal.

Section 14: TRANSPORT INFORMATION

IMDG 14.1 UN/ID No Not regulated14.2 Proper shipping name Not regulated14.3 Hazard class Not regulated14.4 Packing group Not regulated14.5 Marine pollutant Not applicable14.6 Special Provisions None14.7 Transport in bulk according toAnnex II of MARPOL 73/78 and theIBC Code


RID 14.1 UN/ID No Not regulated14.2 Proper shipping name Not regulated14.3 Hazard class Not regulated14.4 Packing group Not regulated14.5 Environmental hazard Not applicable14.6 Special Provisions None

ADR 14.1 UN/ID No Not regulated14.2 Proper shipping name Not regulated14.3 Hazard class Not regulated14.4 Packing group Not regulated14.5 Environmental hazard Not applicable14.6 Special Provisions None

ICAO (air) 14.1 UN/ID No Not regulated14.2 Proper shipping name Not regulated14.3 Hazard class Not regulated14.4 Packing group Not regulated14.5 Environmental hazard Not applicable14.6 Special Provisions None

IATA 14.1 UN/ID No Not regulated14.2 Proper shipping name Not regulated14.3 Hazard class Not regulated14.4 Packing group Not regulated14.5 Environmental hazard Not applicable14.6 Special Provisions None

_____________________________________________________________________________________________




_____________________________________________________________________________________________

Section 15: REGULATORY INFORMATION

15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture

National Regulations

Occupational Illnesses (R-463-3, France)

European Union

Take note of Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents atwork

International Inventories All of the components in the product are on the following Inventory lists TSCA (United States):, Canada (DSL/NDSL),Europe (EINECS/ELINCS), Australia (AICS), South Korea (KECL):, China (IECSC), Philippines (PICCS).

TSCA CompliesEINECS CompliesELINCS -DSL CompliesNDSL CompliesPICCS CompliesENCS -IECSC CompliesAICS CompliesKECL Complies

Legend TSCA - United States Toxic Substances Control Act Section 8(b) Inventory EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List PICCS - Philippines Inventory of Chemicals and Chemical Substances ENCS - Japan Existing and New Chemical Substances IECSC - China Inventory of Existing Chemical Substances AICS - Australian Inventory of Chemical Substances KECL - Korean Existing and Evaluated Chemical Substances

15.2. Chemical safety assessment No information available

Section 16: OTHER INFORMATION


Prepared by EH&S Manager978-927-5054

Prepared by New England BioLabsIssue date No data availableRevision note SDS is valid 3 years from revision date. Contact [email protected] for latest revision.

This safety data sheet complies with the requirements of: Regulation (EC) No. 1907/2006

DisclaimerIMPORTANT: The information in this SDS is provided in good faith based on our knowledge as of the issue date (orsubsequent revision date, if any), and is to be used only as a guide. This SDS does not constitute a guarantee (expressor implied) of any kind and we make no warranties or merchantability or fitness for a particular purpose. This informationrelates only to the designated product as shipped and may not be valid if the product is used in combination with any

_____________________________________________________________________________________________




_____________________________________________________________________________________________

other materials or is not used in accordance with our instructions. It is the responsibility of the buyer/user to ensure thatits activities comply with all applicable governmental requirements. Since conditions of use of the product are not underthe control of New England Biolabs, it is the duty of the buyer/user to determine the necessary conditions for the safe useof the product. New England Biolabs will not be liable for any damages resulting from handling or contact with theproduct.

End of Safety Data Sheet

_____________________________________________________________________________________________







Page 1 of 9




Product name Tris(hydroxymethyl)aminomethane GR for analysis buffer substance

ACS,Reag. Ph Eur






CAS-No. 77-86-1








India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6


number





2.2 Label elements



2.3 Other hazards

None known.


3.1 Substance

Formula H₂NC(CH₂OH)₃ C₄H₁₁NO₃ (Hill)

EC-No. 201-064-4


SAFETY DATA SHEET



Product name Tris(hydroxymethyl)aminomethane GR for analysis buffer substance ACS,Reag.

Ph Eur


Page 2 of 9


1907/2006.

3.2 Mixture

Not applicable





shower.




Nausea, Vomiting, Convulsions, Diarrhoea

The following applies to aliphatic amines in general: irritations after contact with eyes and skin.

Mucosal irritations, coughing, and dyspnoea after inhalation.





Suitable extinguishing mediaWater, Foam, Carbon dioxide (CO2), Dry powder



Combustible.



nitrogen oxides









SAFETY DATA SHEET




Ph Eur


Page 3 of 9








of dusts.



















See section 7.1.






Hand protection

full contact:

SAFETY DATA SHEET




Ph Eur


Page 4 of 9




splash contact:






















Form solid

Colour white

Odour odourless


pH 10.2 - 10.6

at 6 g/l

20 °C

Melting point 168 - 172 °C

Boiling point/boiling range 219 - 220 °C

at 13.3 hPa




SAFETY DATA SHEET




Ph Eur


Page 5 of 9



Vapour pressure 0.000267 Pa

at 20 °C


Density 1.353 g/cm³

at 23 °C



at 20 °C


octanol/water

log Pow: -2.31 (20 °C)








9.2 Other data

Bulk density ca.840 kg/m³


10.1 Reactivity



assumed.





Oxidizing agents, Bases

Caution! In contact with nitrites, nitrates, nitrous acid possible liberation of nitosamines!




SAFETY DATA SHEET




Ph Eur


Page 6 of 9






Acute oral toxicityLD50 Rat: > 5,000 mg/kg



Acute dermal toxicityLD50 Rat: > 5,000 mg/kg

















After swallowing of large amounts:

Diarrhoea, Nausea, Vomiting, Convulsions

The following applies to aliphatic amines in general: irritations after contact with eyes and skin.

Mucosal irritations, coughing, and dyspnoea after inhalation., This substance should be handled

with particular care.

Under given conditions, contact with nitrites or nitric acid can lead to the formation of

nitrosamines, which have shown themselves to be carcinogenic in animal experiments.


SAFETY DATA SHEET




Ph Eur


Page 7 of 9



12.1 Toxicity

Toxicity to fishLC50 Leuciscus idus (Golden orfe): 460 mg/l; 96 h


Toxicity to daphnia and other aquatic invertebratesEC50 Daphnia magna (Water flea): > 980 mg/l; 48 h


Toxicity to algaeErC50 Pseudokirchneriella subcapitata (green algae): 397 mg/l; 72 h


Toxicity to bacteriaEC50 activated sludge: > 1,000 mg/l; 3 h



Biodegradability89 %; 28 d




Partition coefficient: n-octanol/waterlog Pow: -2.31 (20 °C)








Additional ecological informationDischarge into the environment must be avoided.

SAFETY DATA SHEET




Ph Eur


Page 8 of 9


Waste treatment methodsWaste material must be disposed of in accordance with the Directive on waste 2008/98/EC as

well as other national and local regulations. Leave chemicals in original containers. No mixing

with other waste. Handle uncleaned containers like the product itself.






regulations.


Not relevant



regulations.



regulations.


Not relevant








Training advice



Not a hazardous substance or mixture.

EC-No. 201-064-4


SAFETY DATA SHEET




Ph Eur


Page 9 of 9



SAFETY DATA SHEET




Page 1 of 18




Product name Triton® X-100 suitable for the biopharmaceutical production

EMPROVE® bio Ph Eur






CAS-No. 9036-19-5


Identified uses Pharmaceutical production, Reagent for analysis






India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6


number


SAFETY DATA SHEET



Product name Triton® X-100 suitable for the biopharmaceutical production EMPROVE® bio

Ph Eur


Page 2 of 18










2.2 Label elements


Hazard pictograms

Signal word

Danger

Hazard statements






Prevention



Response

SAFETY DATA SHEET




Ph Eur


Page 3 of 18






Hazard pictograms

Signal word

Danger

Hazard statements







Contains: Octylphenol polyethoxyethanol

CAS-No. 9036-19-5

2.3 Other hazards

None known.


3.1 Substance

Formula C₈H₁₇C₆H₄(OCH₂CH₂)nOH C₁₄H₂₁(C₂H₄O)nOH (Hill)

SAFETY DATA SHEET




Ph Eur


Page 4 of 18




Octylphenol polyethoxyethanol (>= 50 % - <= 100 % )

9036-19-5 *)






M-Factor: 10





3.2 Mixture

Not applicable





shower.


contact lenses.

After swallowing: caution if victim vomits. Risk of aspiration! Keep airways free. Pulmonary

failure possible after aspiration of vomit. Call a physician immediately.


Dermatitis, Vomiting


SAFETY DATA SHEET




Ph Eur


Page 5 of 18


Irritation and corrosion











Combustible.








Further information





SAFETY DATA SHEET




Ph Eur


Page 6 of 18


contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency

procedures, consult an expert.







sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ). Dispose of

properly. Clean up affected area.







Hygiene measures




Storage conditions

Tightly closed.



SAFETY DATA SHEET




Ph Eur


Page 7 of 18









See section 7.1.





Eye/face protection


Hand protection

full contact:




splash contact:






898 Butoject® (splash contact).

SAFETY DATA SHEET




Ph Eur


Page 8 of 18








protective clothing



Recommended Filter type: Filter A-(P2)








Form liquid

Colour colourless

Odour weak


pH 5.0 - 8.0

at 10 g/l

20 °C

SAFETY DATA SHEET




Ph Eur


Page 9 of 18

Solidification point 6 °C

Boiling point/boiling range > 200 °C

at 1,013 hPa

Flash point 251 °C

at 1,013 hPa

Method: ASTM D 93





Vapour pressure < 0.01 hPa

at 20 °C


Density 1.07 g/cm3

at 20 °C



soluble


octanol/water

log Pow: 2.7 (20 °C)

(calculated)

(External MSDS) Bioaccumulation is not expected.

SAFETY DATA SHEET




Ph Eur


Page 10 of 18






9.2 Other data

Cloud point 63 - 69 °C


10.1 Reactivity




In case of decomposition in closed containers and tubes risk of bursting due to buildup of

overpressure.



Strong oxidizing agents, Strong acids


Strong heating.



SAFETY DATA SHEET




Ph Eur


Page 11 of 18





Acute oral toxicity

LD50 Rat: 1,900 - 5,000 mg/kg

(External MSDS)

Symptoms: Vomiting, Irritations of mucous membranes in the mouth, pharynx, oesophagus and

gastrointestinal tract., Risk of aspiration upon vomiting., Aspiration may cause pulmonary

oedema and pneumonitis.





(External MSDS)

Skin irritation

Rabbit

Result: irritating


The value is given in analogy to the following substances: 4-(1,1,3,3-tetramethylbutyl)phenol


Drying-out effect resulting in rough and chapped skin. Dermatitis

Eye irritation



SAFETY DATA SHEET




Ph Eur


Page 12 of 18

Sensitisation

Sensitisation test: human

Result: negative

(External MSDS)



Carcinogenicity




Teratogenicity






Aspiration hazard



After absorption:





12.1 Toxicity

SAFETY DATA SHEET




Ph Eur


Page 13 of 18

Toxicity to fish

semi-static test LC50 Leuciscus idus (Golden orfe): 0.26 mg/l; 96 h





static test EC50 Daphnia magna (Water flea): 0.011 mg/l; 48 h

(ECOTOX Database) The value is given in analogy to the following substances: 4-(1,1,3,3-

tetramethylbutyl)phenol

Toxicity to algae

static test EC50 Pseudokirchneriella subcapitata (green algae): 1.9 mg/l; 96 h

(ECHA) The value is given in analogy to the following substances: 4-(1,1,3,3-

tetramethylbutyl)phenol


flow-through test Danio rerio (zebra fish): 0.012 mg/l





semi-static test NOEC Daphnia magna (Water flea): 0.03 mg/l; 21 d





Biodegradability

22 %; 28 d; aerobic

OECD Test Guideline 301C



SAFETY DATA SHEET




Ph Eur


Page 14 of 18


log Pow: 2.7 (20 °C)

(calculated)

(External MSDS) Bioaccumulation is not expected.







Causes endocrine disruption.


SAFETY DATA SHEET




Ph Eur


Page 15 of 18





the product itself.






14.2 Proper shipping name ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID,

N.O.S. (OCTYLPHENOXYPOLYETHOXYETHANOL)

14.3 Class 9




user

yes




Not relevant


SAFETY DATA SHEET




Ph Eur


Page 16 of 18




14.3 Class 9




user

no






14.3 Class 9




user

yes

EmS F-A S-F



Not relevant






SAFETY DATA SHEET




Ph Eur


Page 17 of 18









Training advice


Labelling

Hazard pictograms

Signal word

Danger

Hazard statements






Prevention



SAFETY DATA SHEET




Ph Eur


Page 18 of 18

Response





Contains: Octylphenol polyethoxyethanol





SAFETY DATA SHEET




Page 1 of 13




Product name Tween® 20 (Polysorbate) EMPROVE® ESSENTIAL Ph Eur,JPE,NF






CAS-No. 9005-64-5


Identified uses Pharmaceutical production, Chemical for synthesis, Cosmetic raw

material, Biocidal product






India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6


number


SAFETY DATA SHEET





Page 2 of 13




2.2 Label elements



2.3 Other hazards

None known.


3.1 Substance

Formula C₅₈H₁₁₄O₂₆ (Hill)

Molar mass 1,228 g/mol


1907/2006.

3.2 Mixture

Not applicable





shower.

SAFETY DATA SHEET





Page 3 of 13














Combustible.







Further information




Advice for non-emergency personnel: Do not breathe vapours, aerosols. Evacuate the danger

area, observe emergency procedures, consult an expert.

SAFETY DATA SHEET





Page 4 of 13















Hygiene measures



Storage conditions

Tightly closed.






SAFETY DATA SHEET





Page 5 of 13






See section 7.1.





Eye/face protection

Safety glasses

Hand protection

full contact:




splash contact:





89/686/EEC and the related standard EN374, for example KCL 730 Camatril® -Velours (full

contact), KCL 741 Dermatril® L (splash contact).



SAFETY DATA SHEET





Page 6 of 13






Not required; except in case of aerosol formation.





Form liquid

Colour yellow

Odour odourless


pH 6 - 8

at 50 g/l

20 °C

Melting point No information available.


Flash point 275 °C

at ca.1,013 hPa

Method: DIN 51758

SAFETY DATA SHEET





Page 7 of 13






at 20 °C


Density 1.1 g/cm3

at 25 °C


Water solubility < 0.2 mg/l

at 20 °C



octanol/water




Viscosity, dynamic ca.400 mPa.s

at 25 °C



9.2 Other data

SAFETY DATA SHEET





Page 8 of 13

none


10.1 Reactivity









Strong heating.







Acute oral toxicity


(External MSDS)


LC50 Rat: > 5.1 mg/l; 4 h ; dust/mist


Limit Test (highest concentration to be prepared)

SAFETY DATA SHEET





Page 9 of 13



Skin irritation

Rabbit



Eye irritation


Sensitisation

Maximisation Test Guinea pig





Ames test

Escherichia coli/Salmonella typhimurium

Result: negative



Human lymphocytes

Result: negative



Mouse lymphoma test

Result: negative


Carcinogenicity




SAFETY DATA SHEET





Page 10 of 13

Teratogenicity

Application Route: Oral

Rat

Number of exposures: daily


No indication of teratogenic properties.





Aspiration hazard




appropriately.



12.1 Toxicity

Toxicity to fish

static test LL50 Danio rerio (zebra fish): > 100 mg/l; 96 h



EC50 Daphnia (water flea): > 10 mg/l; 48 h

(above the solubility limit in the test medium) (Lit.)

Toxicity to algae

static test EL50 Pseudokirchneriella subcapitata (green algae): 58.84 mg/l; 72 h


static test EL10 Pseudokirchneriella subcapitata (green algae): 19.05 mg/l; 72 h


SAFETY DATA SHEET





Page 11 of 13


microtox test EC50 Bacteria: 146 - 774 mg/l; 5 min

(Lit.)


semi-static test NOELR Daphnia magna (Water flea): 10 mg/l; 21 d



Biodegradability

> 60 %; 28 d; aerobic

OECD Test Guideline 301F











SAFETY DATA SHEET





Page 12 of 13





the product itself.






regulations.


Not relevant



regulations.



regulations.


Not relevant





SAFETY DATA SHEET





Page 13 of 13




Training advice






SAFETY DATA SHEET




Page 1 of 16




Product name L-Cysteine hydrochloride monohydrate suitable for use as excipient

EMPROVE® exp Ph Eur,USP






CAS-No. 7048-04-6


Identified uses Pharmaceutical production, Cosmetic raw material






India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6

SAFETY DATA SHEET






Page 2 of 16


number







2.2 Label elements


Hazard pictograms

Signal word

Warning

Hazard statements



Response




Hazard pictograms

SAFETY DATA SHEET






Page 3 of 16

Signal word

Warning

CAS-No. 7048-04-6

2.3 Other hazards

None known.


3.1 Substance

Formula C₃H₈ClNO₂S * H₂O C₃H₈ClNO₂S * H₂O (Hill)

EC-No. 200-157-7





L-cysteine hydrochloride monohydrate (>= 80 % - <= 100 % )

7048-04-6 *)






3.2 Mixture

Not applicable




SAFETY DATA SHEET






Page 4 of 16


shower.



physician.


irritant effects










Combustible.



Hydrogen chloride gas, Sulphur oxides, nitrogen oxides





Further information



SAFETY DATA SHEET






Page 5 of 16





expert.








of dusts.







Hygiene measures



Storage conditions




SAFETY DATA SHEET






Page 6 of 16









See section 7.1.





Eye/face protection

Safety glasses

Hand protection

full contact:




splash contact:







SAFETY DATA SHEET






Page 7 of 16








protective clothing




substances








Form solid

Colour white

Odour stinging


SAFETY DATA SHEET






Page 8 of 16

pH 0.8 - 1.2

at 100 g/l

20 °C


at 1,013 hPa


Boiling point/boiling range Method: OECD Test Guideline 103

(decomposition)




Flammability (solids)




at 20 °C



Density 1.54 g/cm3



SAFETY DATA SHEET






Page 9 of 16


at 23 °C



octanol/water

log Pow: -2.2 (23 °C)








9.2 Other data



ca.269.7 µm


10.1 Reactivity



assumed.



SAFETY DATA SHEET






Page 10 of 16



Oxidizing agents









Acute oral toxicity

LD50 Rat: > 2,000 mg/kg





LD50 Rat: > 2,000 mg/kg


Skin irritation

In vitro study



Eye irritation

In vitro study

Result: non-corrosive


SAFETY DATA SHEET






Page 11 of 16

In vitro study

Result: positive


Causes serious eye irritation.

Sensitisation

Local lymph node assay (LLNA) Mouse

Result: negative




Chromosome aberration test

Mouse

male

Intraperitoneal injection

Bone marrow

Result: negative

(Lit.) The value is given in analogy to the following substances: L-cysteine hydrochloride


Ames test


Result: positive


Carcinogenicity




Teratogenicity




SAFETY DATA SHEET






Page 12 of 16



Aspiration hazard






12.1 Toxicity

Toxicity to fish

static test LC50 Danio rerio (zebra fish): > 100 mg/l; 96 h




semi-static test EC50 Daphnia magna (Water flea): > 100 mg/l; 48 h



Toxicity to algae

static test EC50 Desmodesmus subspicatus (green algae): 40.1 mg/l; 72 h



static test EC10 Desmodesmus subspicatus (green algae): 7.5 mg/l; 72 h




static test EC50 activated sludge: 360 mg/l; 3 h



SAFETY DATA SHEET






Page 13 of 16

Biodegradability

95.5 %; 9 d; aerobic





log Pow: -2.2 (23 °C)










SAFETY DATA SHEET






Page 14 of 16







the product itself.




regulations.


Not relevant



regulations.



regulations.


Not relevant





SAFETY DATA SHEET






Page 15 of 16






Training advice


Labelling

Hazard pictograms

Signal word

Warning

Hazard statements



Response




SAFETY DATA SHEET






Page 16 of 16




Aldrich - 516732 Page 1 of 8





1.1 Product identifiers Product name : 2-Mercaptoethanol

Product Number : 516732 Brand : Aldrich REACH No. : A registration number is not available for this substance as the substance


CAS-No. : 60-24-2









Classification according to Regulation (EC) No 1272/2008 Acute toxicity, Oral (Category 3), H301 Acute toxicity, Inhalation (Category 3), H331 Acute toxicity, Dermal (Category 2), H310 Skin irritation (Category 2), H315 Serious eye damage (Category 1), H318 Skin sensitisation (Category 1), H317 Specific target organ toxicity - repeated exposure, Oral (Category 2), Liver, Heart, H373 Acute aquatic toxicity (Category 1), H400 Chronic aquatic toxicity (Category 1), H410


2.2 Label elements


Signal word Danger


Hazard statement(s) H301 + H331 Toxic if swallowed or if inhaled H310 Fatal in contact with skin. H315 Causes skin irritation. H317 May cause an allergic skin reaction. H318 Causes serious eye damage. H373 May cause damage to organs (Liver, Heart) through prolonged or

repeated exposure if swallowed. H410 Very toxic to aquatic life with long lasting effects. Precautionary statement(s) P261 Avoid breathing vapours. P273 Avoid release to the environment. P280 Wear protective gloves/ eye protection/ face protection. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER/doctor. P302 + P350 IF ON SKIN: Gently wash with plenty of soap and water. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. Supplemental Hazard Statements

none

2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. Stench. Stench., Rapidly absorbed through skin.


3.1 Substances Synonyms : beta mercaptoethanol

2-Hydroxyethylmercaptan 2ME Thioethylene glycol β-Mercaptoethanol BME

Formula : C2H6OS

Molecular weight : 78.13 g/mol CAS-No. : 60-24-2 EC-No. : 200-464-6 Hazardous ingredients according to Regulation (EC) No 1272/2008


2-Mercaptoethanol

CAS-No. EC-No.

60-24-2 200-464-6

Acute Tox. 3; Acute Tox. 2; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1; STOT RE 2; Aquatic Acute 1; Aquatic Chronic 1; H301, H331, H310, H315, H318, H317, H373, H400, H410

M-Factor - Aquatic Acute: 1

<= 100 %







In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.






5.2 Special hazards arising from the substance or mixture Carbon oxides, Sulphur oxides


5.4 Further information Use water spray to cool unopened containers.


6.1 Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. For personal protection see section 8.

6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13). Keep in suitable, closed containers for disposal.



7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.


Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials





Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.


Eye/face protection Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Full contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) Splash contact Material: Nature latex/chloroprene Minimum layer thickness: 0.6 mm Break through time: 30 min Material tested:Lapren® (KCL 706 / Aldrich Z677558, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use (US) or type ABEK (EN 14387) respirator cartridges as a backup to enginee protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).


Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.



a) Appearance Form: liquid Colour: colourlessyellow

b) Odour Stench.


d) pH 4.5 - 6 at 500 g/l at 20 °C


< -49.99 °C


157 °C - lit.

g) Flash point 74 °C - closed cup




Upper explosion limit: 18 %(V) Lower explosion limit: 2.3 %(V)

k) Vapour pressure 0.76 mbar at 20 °C 4.67 mbar at 40 °C

l) Vapour density 2.70 - (Air = 1.0)

m) Relative density 1.114 g/cm3 at 25 °C

n) Water solubility soluble


log Pow: -0.326log Pow: -0.056 at 25 °C


No data available


No data available




9.2 Other safety information

Relative vapour density 2.70 - (Air = 1.0)






10.4 Conditions to avoid Heat, flames and sparks.

10.5 Incompatible materials Metals, Oxidizing agents

10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Carbon oxides, Sulphur oxides Other decomposition products - No data available In the event of fire: see section 5



Acute toxicity LD50 Oral - Rat - 98 - 162 mg/kg(2-Mercaptoethanol) (OECD Test Guideline 401) LC50 Inhalation - Rat - 4 h - 2 mg/l(2-Mercaptoethanol) LC50 Inhalation - Rat - 4 h - 625 ppm(2-Mercaptoethanol) LD50 Dermal - Rabbit - 112 mg/kg(2-Mercaptoethanol)

Skin corrosion/irritation Skin - Rabbit(2-Mercaptoethanol) Result: Irritating to skin. (Draize Test)

Serious eye damage/eye irritation Eyes - Rabbit(2-Mercaptoethanol) Result: Risk of serious damage to eyes.

Respiratory or skin sensitisation Maximisation Test - Guinea pig(2-Mercaptoethanol) May cause sensitisation by skin contact. (OECD Test Guideline 406)


Carcinogenicity


Reproductive toxicity No data available(2-Mercaptoethanol)

Specific target organ toxicity - single exposure No data available(2-Mercaptoethanol)

Specific target organ toxicity - repeated exposure Ingestion - May cause damage to organs through prolonged or repeated exposure. - Liver, Heart

Aspiration hazard No data available(2-Mercaptoethanol)

Additional Information RTECS: KL5600000 burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea, Vomiting, Weakness, Unconsciousness, Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema(2-Mercaptoethanol) To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(2-Mercaptoethanol)



12.1 Toxicity Toxicity to fish LC50 - Leuciscus idus (Golden orfe) - 46 - 100 mg/l - 96.0 h(2-

Mercaptoethanol) Toxicity to daphnia and other aquatic invertebrates

EC50 - Daphnia (water flea) - 0.89 mg/l - 48 h(2-Mercaptoethanol) (OECD Test Guideline 202)

Toxicity to algae EC50 - Desmodesmus subspicatus (green algae) - 12 mg/l - 72 h(2-

Mercaptoethanol) Toxicity to bacteria LC50 - Bacteria - 125 mg/l - 17 h(2-Mercaptoethanol)

12.2 Persistence and degradability Biodegradability Result: < 30.0 % - Not readily biodegradable. Result: 6 % - Not readily biodegradable. aerobic - Exposure time 28 d(2-Mercaptoethanol)

Result: < 10 % - Not readily biodegradable. Biochemical Oxygen Demand (BOD)

105 mg/g(2-Mercaptoethanol)


1.894 mg/g(2-Mercaptoethanol)

12.3 Bioaccumulative potential Does not accumulate in organisms.

12.4 Mobility in soil No data available(2-Mercaptoethanol)


12.6 Other adverse effects Very toxic to aquatic life with long lasting effects.



Product This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company.



14.1 UN number ADR/RID: 2966 IMDG: 2966 IATA: 2966

14.2 UN proper shipping name ADR/RID: THIOGLYCOL IMDG: THIOGLYCOL IATA: Thioglycol

14.3 Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1

14.4 Packaging group ADR/RID: II IMDG: II IATA: II









H301 Toxic if swallowed. H301 + H331 Toxic if swallowed or if inhaled H310 Fatal in contact with skin. H315 Causes skin irritation. H317 May cause an allergic skin reaction. H318 Causes serious eye damage. H331 Toxic if inhaled. H373 May cause damage to organs through prolonged or repeated exposure if swallowed. H400 Very toxic to aquatic life. H410 Very toxic to aquatic life with long lasting effects.


Version: 1.2 Revision Date: 03-13-2018

SDS_US - SDS000001587 1/10

SAFETY DATA SHEET According to US Regulation 29 CFR 1910.1200 (HazCom 2012)

1. Identification

Product identifier: L-Arginine

Other means of identification

Product No.: 2066, 4932

Recommended restrictions

Recommended use: For Laboratory, Research or Manufacturing Use. Restrictions on use: Not determined.


Manufacturer

Company Name: Avantor Performance Materials, LLC. Address: 3477 Corporate Parkway

Center Valley, PA 18034

Telephone: Customer Service: 855-282-6867

Fax: 610-573-2610 Contact Person: Environmental Health & Safety E-mail: [email protected]

Emergency telephone number: CHEMTREC: 1-800-424-9300 within US and Canada

2. Hazard(s) identification

Hazard Classification

Health Hazards

Serious Eye Damage/Eye Irritation Category 2A

Unknown toxicity - Health

Acute toxicity, dermal 100 %

Acute toxicity, inhalation, vapor 100 %

Acute toxicity, inhalation, dust or mist

100 %

Hazard Symbol: No symbol

Signal Word: Warning

Hazard Statement: Causes eye irritation.

Label Elements


SDS_US - SDS000001587 2/10

Precautionary Statements

Prevention: Wash hands thoroughly after handling.

Response: IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention.

Hazard(s) not otherwise classified (HNOC):

None.

3. Composition/information on ingredients

Substances

Chemical Identity CAS number Content in percent (%)*

L-Arginine 74-79-3 100% * All concentrations are percent by weight unless ingredient is a gas. Gas concentrations are in percent by volume.


General information: Get medical advice/attention if you feel unwell. Show this safety data sheet

to the doctor in attendance. Ingestion: Rinse mouth. Call a POISON CENTER/doctor if you feel unwell.

Inhalation: Move to fresh air. Get medical attention if symptoms persist.

Skin Contact: Wash skin thoroughly with soap and water. Get medical attention if

symptoms occur. Eye contact: Immediately flush with plenty of water for at least 15 minutes. If easy to do,

remove contact lenses. Get medical attention. Most important symptoms/effects, acute and delayed

Symptoms: Irritating to eyes, respiratory system and skin.

Hazards: None known.

Indication of immediate medical attention and special treatment needed

Treatment: Treat symptomatically.

5. Fire-fighting measures

General Fire Hazards: No unusual fire or explosion hazards noted.

Suitable (and unsuitable) extinguishing media

Suitable extinguishing media:

Extinguish with foam, carbon dioxide, dry powder or water fog.


SDS_US - SDS000001587 3/10

Unsuitable extinguishing media:

None known.

Specific hazards arising from

the chemical: During fire, gases hazardous to health may be formed.

Special protective equipment and precautions for firefighters

Special fire fighting procedures:

Move containers from fire area if you can do so without risk. Use water spray to keep fire-exposed containers cool. Cool containers exposed to flames with water until well after the fire is out.

Special protective equipment for fire-fighters:

Firefighters must use standard protective equipment including flame retardant coat, helmet with face shield, gloves, rubber boots, and in enclosed spaces, SCBA.

6. Accidental release measures

Personal precautions,

protective equipment and emergency procedures:

Keep unauthorized personnel away. Ventilate closed spaces before entering them. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Avoid inhalation of dust. See Section 8 of the SDS for Personal Protective Equipment.

Methods and material for

containment and cleaning up:

Sweep up and place in a clearly labeled container for chemical waste. Clean surface thoroughly to remove residual contamination.

Notification Procedures: Prevent entry into waterways, sewer, basements or confined areas. Stop

the flow of material, if this is without risk. Inform authorities if large amounts are involved.

Environmental Precautions: Do not contaminate water sources or sewer. Prevent further leakage or

spillage if safe to do so.

7. Handling and storage

Precautions for safe handling: Avoid contact with eyes, skin, and clothing. Avoid inhalation of dust. Wash

hands thoroughly after handling. See Section 8 of the SDS for Personal Protective Equipment.

Conditions for safe storage,

including any incompatibilities:

Keep container tightly closed in a cool, well-ventilated place.

8. Exposure controls/personal protection

Control Parameters

Occupational Exposure Limits None of the components have assigned exposure limits.

Appropriate Engineering

Controls No data available.


SDS_US - SDS000001587 4/10

Individual protection measures, such as personal protective equipment

General information: Good general ventilation (typically 10 air changes per hour) should be used. Ventilation rates should be matched to conditions. If applicable, use process enclosures, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits. If exposure limits have not been established, maintain airborne levels to an acceptable level.

Eye/face protection: Wear safety glasses with side shields (or goggles).

Skin Protection

Hand Protection: Chemical resistant gloves

Other: Wear suitable protective clothing.

Respiratory Protection: In case of inadequate ventilation use suitable respirator.

Hygiene measures: Provide eyewash station and safety shower. Always observe good personal hygiene measures, such as washing after handling the material and before eating, drinking, and/or smoking. Routinely wash work clothing to remove contaminants. Discard contaminated footwear that cannot be cleaned.

9. Physical and chemical properties

Appearance

Physical state: Solid

Form: Crystals or powder.

Color: Colorless

Odor: Odorless

Odor threshold: No data available.

pH: No data available.

Melting point/freezing point: 223 - 224 °C

Initial boiling point and boiling range: No data available.

Flash Point: No data available.

Evaporation rate: No data available.

Flammability (solid, gas): No data available.

Upper/lower limit on flammability or explosive limits

Flammability limit - upper (%): No data available.

Flammability limit - lower (%): No data available.

Explosive limit - upper (%): No data available.

Explosive limit - lower (%): No data available.

Vapor pressure: No data available.

Vapor density: No data available.

Density: 1.46 g/cm3 (20 °C)

Relative density: 1.46 (20 °C)

Solubility(ies)

Solubility in water: 182 g/l (25 °C)

Solubility (other): ethanol: Slightly Soluble ethyl ether: Insoluble

Partition coefficient (n-octanol/water): -4.20

Auto-ignition temperature: 380 °C

Decomposition temperature: No data available.

Viscosity: No data available.


SDS_US - SDS000001587 5/10

Other information

Molecular weight: 174.2 g/mol (C6H14N4O2)


Reactivity: No dangerous reaction known under conditions of normal use.

Chemical Stability: Material is stable under normal conditions.

Possibility of hazardous

reactions: Hazardous polymerization does not occur.

Conditions to avoid: Contact with incompatible materials.

Incompatible Materials: Strong oxidizing agents.

Hazardous Decomposition

Products: Thermal decomposition may produce oxides of carbon and nitrogen.

11. Toxicological information

Information on likely routes of exposure

Inhalation: Dust may irritate respiratory system.

Skin Contact: May cause irritation.

Eye contact: Causes eye irritation.

Ingestion: May cause irritation of the gastrointestinal tract.

Information on toxicological effects

Acute toxicity (list all possible routes of exposure)

Oral Product: LD 50 (Rat): 3,792 mg/kg

Dermal

Product: No data available.

Inhalation Product: No data available.

Repeated dose toxicity Product: No data available.

Skin Corrosion/Irritation Product: May cause skin irritation.

Serious Eye Damage/Eye Irritation

Product: Causes eye irritation.

Respiratory or Skin Sensitization Product: Not a skin sensitizer.

Carcinogenicity


SDS_US - SDS000001587 6/10

Product: This substance has no evidence of carcinogenic properties.

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: No carcinogenic components identified

US. National Toxicology Program (NTP) Report on Carcinogens: No carcinogenic components identified

US. OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050): No carcinogenic components identified

Germ Cell Mutagenicity

In vitro Product: No mutagenic components identified

In vivo

Product: No mutagenic components identified

Reproductive toxicity Product: No components toxic to reproduction

Specific Target Organ Toxicity - Single Exposure

Product: Respiratory tract irritation.

Specific Target Organ Toxicity - Repeated Exposure Product: None known.

Aspiration Hazard

Product: Not classified

Other effects: None known.

12. Ecological information

Ecotoxicity:

Acute hazards to the aquatic environment:

Fish Product: No data available.

Specified substance(s):

L-Arginine NOAEL (Danio rerio, 96 h): 1.8 g/l LC 50 (Danio rerio, 96 h): 2.8 g/l

Aquatic Invertebrates


Specified substance(s): L-Arginine EC 50 (Daphnia magna, 24 h): 1.8 g/l

NOAEL (Daphnia magna, 24 h): 1 g/l

Chronic hazards to the aquatic environment:


SDS_US - SDS000001587 7/10


Aquatic Invertebrates Product: No data available.

Toxicity to Aquatic Plants Product: No data available.

Persistence and Degradability

Biodegradation Product: There are no data on the degradability of this product.

BOD/COD Ratio


Bioaccumulative potential Bioconcentration Factor (BCF)

Product: No data available on bioaccumulation. Partition Coefficient n-octanol / water (log Kow)

Product: Log Kow: -4.20 Mobility in soil: The product is water soluble and may spread in water systems.

Other adverse effects: The product components are not classified as environmentally hazardous.

However, this does not exclude the possibility that large or frequent spills can have a harmful or damaging effect on the environment.

13. Disposal considerations

Disposal instructions: Discharge, treatment, or disposal may be subject to national, state, or local

laws. Contaminated Packaging: Since emptied containers retain product residue, follow label warnings even

after container is emptied.


DOT

Not regulated.

IMDG Not regulated.

IATA

Not regulated.


US Federal Regulations

TSCA Section 12(b) Export Notification (40 CFR 707, Subpt. D) None present or none present in regulated quantities.


SDS_US - SDS000001587 8/10

US. OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050) None present or none present in regulated quantities.

CERCLA Hazardous Substance List (40 CFR 302.4): None present or none present in regulated quantities.

Superfund Amendments and Reauthorization Act of 1986 (SARA)

Hazard categories

Serious eye damage or eye irritation

SARA 302 Extremely Hazardous Substance None present or none present in regulated quantities.

SARA 304 Emergency Release Notification

None present or none present in regulated quantities.

SARA 311/312 Hazardous Chemical Chemical Identity Threshold Planning Quantity L-Arginine 10000 lbs.

SARA 313 (TRI Reporting) None present or none present in regulated quantities.

Clean Air Act (CAA) Section 112(r) Accidental Release Prevention (40 CFR 68.130):

None present or none present in regulated quantities. None present or none present in regulated quantities.

Chemical Identity Reportable quantity Clean Water Act Section 311 Hazardous Substances (40 CFR 117.3):

None present or none present in regulated quantities. None present or none present in regulated quantities.

US State Regulations

US. California Proposition 65

No ingredient regulated by CA Prop 65 present.

US. New Jersey Worker and Community Right-to-Know Act No ingredient regulated by NJ Right-to-Know Law present.

US. Massachusetts RTK - Substance List

No ingredient regulated by MA Right-to-Know Law present.

US. Pennsylvania RTK - Hazardous Substances No ingredient regulated by PA Right-to-Know Law present.

US. Rhode Island RTK

No ingredient regulated by RI Right-to-Know Law present. International regulations

Montreal protocol

not applicable

Stockholm convention

not applicable


SDS_US - SDS000001587 9/10

Rotterdam convention

not applicable

Kyoto protocol not applicable

Inventory Status:

Australia AICS: On or in compliance with the inventory Canada DSL Inventory List: On or in compliance with the inventory EINECS, ELINCS or NLP: On or in compliance with the inventory Japan (ENCS) List: On or in compliance with the inventory Korea Existing Chemicals Inv. (KECI): On or in compliance with the inventory Philippines PICCS: On or in compliance with the inventory US TSCA Inventory: On or in compliance with the inventory New Zealand Inventory of Chemicals: On or in compliance with the inventory Japan ISHL Listing: On or in compliance with the inventory China Inv. Existing Chemical Substances: On or in compliance with the inventory Mexico INSQ: On or in compliance with the inventory Taiwan Chemical Substance Inventory: On or in compliance with the inventory

16.Other information, including date of preparation or last revision

Issue Date: 03-13-2018

Revision Information: Not relevant.

Version #: 1.2

Source of information: Sources of information used in preparing this SDS included one or more of the following: results from in house or supplier toxicology studies, information from the Toxicology Data Network (TOXNET), European Chemical Agency (ECHA) substance dossiers, IARC Monographs, US National Toxicology Program data, the Agency for Toxic Substances and Disease Registry, other manufacturer’s SDSs and other sources, as appropriate.

Further Information: No data available.


SDS_US - SDS000001587 10/10

Disclaimer: The information provided in this Safety Data Sheet (SDS) was prepared based on data believed to be accurate as of the date of this SDS. TO THE GREATEST EXTENT PERMITTED BY LAW, AVANTOR PERFORMANCE MATERIALS (“AVANTOR”) EXPRESSLY DISCLAIMS ANY AND ALL REPRESENTATIONS AND WARRANTIES REGARDING THE INFORMATION CONTAINED HEREIN INCLUDING, WITHOUT LIMITATION, AS TO ACCURACY, COMPLETENESS, FITNESS FOR PURPOSE OR USE, MERCHANTABILITY, NON-INFRINGEMENT, PERFORMANCE, SAFETY, SUITABILITY AND STABILITY. This SDS is intended as a guide to the appropriate use, handling, storage and disposal of the product to which it relates by properly trained personnel, and is not intended to be comprehensive. Users of Avantor’s products are advised to perform their own tests and to exercise their own judgment to determine the safety, suitability and appropriate use, handling, storage and disposal of each product and product combination for their own purposes and uses. TO THE GREATEST EXTENT PERMITTED BY LAW, AVANTOR DISCLAIMS LIABILITY FOR, AND BY USING AVANTOR’S PRODUCTS PURCHASER AGREES THAT UNDER NO CIRCUMSTANCES SHALL AVANTOR BE LIABLE FOR, SPECIAL, INDIRECT, INCIDENTAL , PUNITIVE OR CONSEQUENTIAL DAMAGES OF ANY TYPE OR KIND, INCLUDING WITHOUT LIMITATION, FOR LOSS OF PROFITS, REPUTATIONAL DAMAGE, PRODUCT RECALL OR BUSINESS INTERRUPTION.

SAFETY DATA SHEET




Page 1 of 24



Catalogue No. D45399

Product code 4015

Product name Imidazole, ULTROL® Grade

REACH Registration Number 01-2119485825-24-XXXX

CAS-No. 288-32-4


Identified uses Reagent for development and research

In compliance with the conditions described in the annex to this safety

data sheet.


Company Merck KGaA * 64271 Darmstadt * Germany * Phone:+49 6151 72-0

Responsible Department LS-QHC * e-mail: [email protected]


number






Skin corrosion, Category 1C, H314

Reproductive toxicity, Category 1B, H360D


SAFETY DATA SHEET





Page 2 of 24

2.2 Label elements


Hazard pictograms

Signal word

Danger

Hazard statements

H360D May damage the unborn child.




Prevention



Response







Hazard pictograms

Signal word

Danger

Hazard statements





SAFETY DATA SHEET





Page 3 of 24






Contains: Imidazole

Index-No. 613-319-00-0

2.3 Other hazards

None known.


3.1 Substance

Formula C₃H₄N₂ (Hill)

Index-No. 613-319-00-0

EC-No. 206-019-2

Molar mass 68,08 g/mol


Chemical Name (Concentration)


Imidazole (<= 100 % )


288-32-4 01-2119485825-24-

XXXX


Skin corrosion, Category 1C, H314

Reproductive toxicity, Category 1B, H360D


3.2 Mixture

Not applicable



SAFETY DATA SHEET





Page 4 of 24

General advice





After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.


perforation). Do not attempt to neutralise. Call a physician immediately.


Irritation and corrosion, Cough, Shortness of breath

Risk of blindness!










Combustible.




nitrous gases, nitrogen oxides





SAFETY DATA SHEET





Page 5 of 24

Further information





Advice for non-emergency personnel: Avoid substance contact. Avoid inhalation of dusts. Ensure


expert.















Hygiene measures




Storage conditions

Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only

to qualified or authorised persons.

SAFETY DATA SHEET





Page 6 of 24



See exposure scenario in the Annex to this MSDS.



Derived No Effect Level (DNEL)

Worker DNEL, longterm Systemic effects inhalation 10,6 mg/m³

Worker DNEL, longterm Systemic effects dermal 1,5 mg/kg Body weight

Predicted No Effect Concentration (PNEC)

PNEC Fresh water 0,13 mg/l

PNEC Marine water 0,013 mg/l

PNEC Aquatic intermittent release 1,3 mg/l

PNEC Fresh water sediment 0,336 mg/kg

PNEC Marine sediment 0,0336 mg/kg

PNEC Soil 0,0425 mg/kg

PNEC Sewage treatment plant 10 mg/l





See section 7.1.





SAFETY DATA SHEET





Page 7 of 24

Eye/face protection


Hand protection

full contact:


Glove thickness: 0,11 mm


splash contact:


Glove thickness: 0,11 mm












protective clothing



Recommended Filter type: Filter P 3 (acc. to DIN 3181) for solid and liquid particles of toxic

and very toxic substances








SAFETY DATA SHEET





Page 8 of 24

Form solid

Colour light yellow

Odour amine-like


pH 10,5

at 67 g/l

20 °C



Boiling point/boiling range 268 °C

at 1.013 hPa

(ECHA)

Flash point 145 °C

Method: DIN 51758



Flammability (solids)



Vapour pressure 0,003 hPa

at 20 °C



SAFETY DATA SHEET





Page 9 of 24

Density 1,233 g/cm3

at 20 °C




at 20 °C


octanol/water

log Pow: -0,02


Bioaccumulation is not expected. (Lit.)



Viscosity, dynamic 2,696 mPa.s

at 100 °C



9.2 Other data


Method: DIN 51794

Bulk density 500 - 600 kg/m3


ca.1 mm


10.1 Reactivity



SAFETY DATA SHEET





Page 10 of 24



assumed.





Strong oxidizing agents, Acid chlorides, Acid anhydrides, acids


Strong heating.







Acute oral toxicity

LD50 Rat: 970 mg/kg




absorption


Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of

respiratory tract, Lung oedema



SAFETY DATA SHEET





Page 11 of 24

Skin irritation

Rabbit

Result: Corrosive


Burns after prolonged exposure.

Eye irritation

Rabbit

Result: Causes serious eye damage.



Risk of blindness!

Sensitisation





Mouse

male and female

Oral

Bone marrow

Result: negative



unscheduled DNA synthesis assay

rat hepatocytes

Result: negative


Ames test


Result: negative



Chinese hamster lung cells

Result: negative


SAFETY DATA SHEET





Page 12 of 24

Carcinogenicity




Teratogenicity


CMR effects

Teratogenicity:

May damage the unborn child.





Aspiration hazard



After absorption:





12.1 Toxicity

Toxicity to fish

LC50 Leuciscus idus (Golden orfe): ca. 280 mg/l; 48 h

DIN 37 412 T 15

(External MSDS)


static test EC50 Daphnia magna (Water flea): 341,5 mg/l; 48 h


Toxicity to algae

static test ErC50 Desmodesmus subspicatus (green algae): 133 mg/l; 72 h

DIN 38412

SAFETY DATA SHEET





Page 13 of 24


Respiration inhibition EC50 activated sludge: > 1.000 mg/l; 30 min



Biodegradability

90 - 100 %; 18 d; aerobic





log Pow: -0,02


Bioaccumulation is not expected. (Lit.)








When discharged properly, no impairments in the function of adapted biological wastewater

treatment plants are to be expected.

Depending on the concentration, phosphorus and/or nitrogen compounds may contribute to the

eutrophication of drinking- water supplies.


SAFETY DATA SHEET





Page 14 of 24








14.2 Proper shipping name CORROSIVE SOLID, BASIC, ORGANIC, N.O.S.

(IMIDAZOLE)

14.3 Class 8




user

yes



Not relevant




(IMIDAZOLE)

14.3 Class 8




user

no


SAFETY DATA SHEET





Page 15 of 24



(IMIDAZOLE)

14.3 Class 8




user

yes

EmS F-A S-B


Not relevant



EU regulations

Major Accident Hazard

Legislation

SEVESO III

Not applicable

Occupational restrictions Take note of Dir 94/33/EC on the protection of young people at

work. Observe work restrictions regarding maternity protection in

accordance to Dir 92/85/EEC or stricter national regulations where

applicable.

Regulation (EC) No 1005/2009 on substances that

deplete the ozone layer

not regulated

Regulation (EC) No 850/2004 of the European

Parliament and of the Council of 29 April 2004 on

persistent organic pollutants and amending

Directive 79/117/EEC

not regulated

Substances of very high concern (SVHC) This product does not contain substances

of very high concern according to

Regulation (EC) No 1907/2006 (REACH),

Article 57 above the respective regulatory

concentration limit of ≥ 0.1 % (w/w).

SAFETY DATA SHEET





Page 16 of 24


Storage class 6.1C








Training advice


Labelling

Hazard pictograms

Signal word

Danger

Hazard statements





Prevention



Response


SAFETY DATA SHEET





Page 17 of 24




Further information


Contains: Imidazole



Regional representation

This information is given on the authorised Safety Data Sheet for your country.



SAFETY DATA SHEET – Annex





Page 18 of 24

EXPOSURE SCENARIO 1 (Industrial use)

1. Industrial use Reagent for development and research)

Sectors of end-use

SU 3 Industrial uses: Uses of substances as such or in preparations at industrial sites

SU9 Manufacture of fine chemicals

SU 10 Formulation [mixing] of preparations and/ or re-packaging (excluding alloys)

Chemical product category

PC21 Laboratory chemicals

Process categories

PROC1 Use in closed process, no likelihood of exposure

PROC2 Use in closed, continuous process with occasional controlled exposure

PROC3 Use in closed batch process (synthesis or formulation)

PROC4 Use in batch and other process (synthesis) where opportunity for exposure arises

PROC5 Mixing or blending in batch processes for formulation of preparations and articles

(multistage and/ or significant contact)

PROC8a Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large

containers at non-dedicated facilities

PROC8b Transfer of substance or preparation (charging/ discharging) from/ to vessels/ large

containers at dedicated facilities

PROC9 Transfer of substance or preparation into small containers (dedicated filling line, including

weighing)

PROC10 Roller application or brushing

PROC15 Use as laboratory reagent

Environmental Release Categories

ERC1 Manufacture of substances

ERC2 Formulation of preparations

ERC6a Industrial use resulting in manufacture of another substance (use of intermediates)

ERC6b Industrial use of reactive processing aids

2. Contributing scenarios: Operational conditions and risk management measures

2.1 Contributing scenario controlling worker exposure for: PROC1, PROC2, PROC3, PROC4, PROC5, PROC8a,

PROC8b, PROC9, PROC15






Page 19 of 24

Product characteristics

Concentration of the Substance in

Mixture/Article

Covers the percentage of the substance in the product up to

100 %.

Physical Form (at time of use) Solid, low dustiness

Frequency and duration of use

Frequency of use 8 hours/day

Frequency of use 5 days/week

Other operational conditions affecting workers exposure

Outdoor / Indoor Indoor without local exhaust ventilation (LEV)

Organisational measures to prevent /limit releases, dispersion and exposure

Covers daily exposures up to 8 hours.

Conditions and measures related to personal protection, hygiene and health evaluation

Wear chemically resistant gloves (tested to EN374) in combination with ‘basic’ employee training. Use

suitable eye protection. Wear suitable coveralls to prevent exposure to the skin.

Additional good practice advice beyond the REACH Chemical Safety Assessment

Additional good practice advice Avoid contact with the skin and the eyes. Do not inhale

substance/mixture.

2.2 Contributing scenario controlling worker exposure for: PROC10



Mixture/Article


10 %.














Page 20 of 24






substance/mixture.

3. Exposure estimation and reference to its source

Environment

A chemical safety assessment was performed according REACH Article 14(3), Annex I, sections 3

(Environmental Hazard Assessment) and 4 (PBT/vPvB Assessment). As no hazard was identified, an exposure

assessment and risk characterisation is not necessary (REACH Annex I section 5.0).






Page 21 of 24

Workers

CS Use descriptor Exposure duration, route, effect RCR Exposure Assessment Method

2.1 PROC1 longterm, dermal, systemic 0,02 ECETOC TRA, modified

longterm, inhalative, systemic < 0,01 ECETOC TRA, modified

longterm, combined, systemic 0,02


longterm, inhalative, systemic < 0,01 ECETOC TRA, modified



longterm, inhalative, systemic 0,01 ECETOC TRA, modified








2.1 PROC8a longterm, dermal, systemic 0,91 ECETOC TRA, modified



2.1 PROC8b longterm, dermal, systemic 0,46 ECETOC TRA, modified












The default parameters and -efficiencies of the applied exposure assessment model were used for

the calculation (unless stated differently).

For (other) local effects risk management measures are based on qualitative risk characterisation.






Page 22 of 24

4. Guidance to Downstream User to evaluate whether he works inside the boundaries set by the Exposure

Scenario

Please refer to the following documents: ECHA Guidance on information requirements and chemical

safety assessment Chapter R.12: Use descriptor system; ECHA Guidance for downstream users;

ECHA Guidance on information requirements and chemical safety assessment Part D: Exposure

Scenario Building, Part E: Risk Characterisation and Part G: Extending the SDS; VCI/Cefic REACH

Practical Guides on Exposure Assessment and Communications in the Supply Chain; CEFIC

Guidance Specific Environmental Release Categories (SPERCs).

For scaling of worker exposure assessments performed with ECETOC TRA, please consult the Merck

tool ScIDeEx® at www.merckmillipore.com/scideex.






Page 23 of 24

EXPOSURE SCENARIO 2 (Professional use)

1. Professional use Reagent for development and research)

Sectors of end-use

SU 22 Professional uses: Public domain (administration, education, entertainment, services,

craftsmen)

Chemical product category

PC21 Laboratory chemicals

Process categories

PROC15 Use as laboratory reagent

Environmental Release Categories

ERC2 Formulation of preparations

ERC6a Industrial use resulting in manufacture of another substance (use of intermediates)

ERC6b Industrial use of reactive processing aids

2. Contributing scenarios: Operational conditions and risk management measures

2.1 Contributing scenario controlling worker exposure for: PROC15



Mixture/Article


100 %.
















Page 24 of 24




substance/mixture.

3. Exposure estimation and reference to its source

Environment

A chemical safety assessment was performed according REACH Article 14(3), Annex I, sections 3

(Environmental Hazard Assessment) and 4 (PBT/vPvB Assessment). As no hazard was identified, an exposure

assessment and risk characterisation is not necessary (REACH Annex I section 5.0).

Workers

CS Use descriptor Exposure duration, route, effect RCR Exposure Assessment Method




The default parameters and -efficiencies of the applied exposure assessment model were used for

the calculation (unless stated differently).

For (other) local effects risk management measures are based on qualitative risk characterisation.

4. Guidance to Downstream User to evaluate whether he works inside the boundaries set by the Exposure

Scenario

Please refer to the following documents: ECHA Guidance on information requirements and chemical

safety assessment Chapter R.12: Use descriptor system; ECHA Guidance for downstream users;

ECHA Guidance on information requirements and chemical safety assessment Part D: Exposure

Scenario Building, Part E: Risk Characterisation and Part G: Extending the SDS; VCI/Cefic REACH

Practical Guides on Exposure Assessment and Communications in the Supply Chain; CEFIC

Guidance Specific Environmental Release Categories (SPERCs).

For scaling of worker exposure assessments performed with ECETOC TRA, please consult the Merck

tool ScIDeEx® at www.merckmillipore.com/scideex.

Citraconic Anhydride

2,5-Furandione, 3-methyl-

Liquid.

CHEMTREC: 800.424.9300Outside US: 703.527.3887

SAFETY DATA SHEET

GHS product identifier


Product type

Emergency telephone number (with hours of operation)

Section 1. Identification:

:

:

Chemical name : citraconic anhydride

Supplier's details : Thermo Fisher Scientific Pierce BiotechnologyP.O. Box 117Rockford, IL 61105United States815.968.0747 or800.874.37237 AM - 5 PM Central Time (GMT -06:00)


Relevant identified uses of the substance or mixture and uses advised against

Not applicable.

Product code

SDS #

CAS #

Chemical formula

:

:

:

:

:

0020907 0020907B 1871270 1900417 NCI2090

2139

C5-H4-O3

616-02-4

Section 2. Hazards identification

ACUTE TOXICITY (dermal) - Category 3SKIN CORROSION/IRRITATION - Category 1BSERIOUS EYE DAMAGE/ EYE IRRITATION - Category 2ARESPIRATORY SENSITIZATION - Category 1SKIN SENSITIZATION - Category 1SPECIFIC TARGET ORGAN TOXICITY (SINGLE EXPOSURE) (Respiratory tract irritation) - Category 3

Classification of the substance or mixture

:

Signal word : Danger

Hazard statements : Toxic in contact with skin.Causes severe skin burns and eye damage.May cause allergy or asthma symptoms or breathing difficulties if inhaled.May cause an allergic skin reaction.May cause respiratory irritation.

Hazard pictograms :


Prevention : Wear protective gloves. Wear eye or face protection. Wear protective clothing. In case of inadequate ventilation wear respiratory protection. Use only outdoors or in a well-ventilated area. Avoid breathing vapor. Wash hands thoroughly after handling.Contaminated work clothing should not be allowed out of the workplace.

GHS label elements

OSHA/HCS status : This material is considered hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200).

Date of issue/Date of revision : 6/25/2014. Date of previous issue : No previous validation. Version : 1 1/11


Section 2. Hazards identificationResponse : IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for

breathing. Immediately call a POISON CENTER or physician. If experiencing respiratory symptoms: Call a POISON CENTER or physician. IF SWALLOWED:Immediately call a POISON CENTER or physician. Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower. Wash contaminated clothing before reuse. Immediately call a POISON CENTER or physician. IF ON SKIN: Wash with plenty of soap and water. Call a POISON CENTER or physician if you feel unwell. If skin irritation or rash occurs: Get medical attention. IF IN EYES: Rinse cautiously with water for several minutes.Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or physician. If eye irritation persists: Get medical attention.

Storage : Store locked up.

Disposal : Dispose of contents and container in accordance with all local, regional, national and international regulations.

Hazards not otherwise classified

: None known.

Section 3. Composition/information on ingredients

citraconic anhydride 98 - 100 616-02-4

Ingredient name CAS number%

There are no additional ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in this section.

Chemical name : citraconic anhydride


: 2,5-Furandione, 3-methyl-

CAS number : 616-02-4

Substance/mixture

CAS number/other identifiers

:

Occupational exposure limits, if available, are listed in Section 8.

Substance

Any concentration shown as a range is to protect confidentiality or is due to batch variation.

Get medical attention immediately. Call a poison center or physician. Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes. Chemical burns must be treated promptly by a physician.

Get medical attention immediately. Call a poison center or physician. Wash with plenty of soap and water. Remove contaminated clothing and shoes. Wash contaminated clothing thoroughly with water before removing it, or wear gloves. Continue to rinse for at least 10 minutes. Chemical burns must be treated promptly by a physician. In the event of any complaints or symptoms, avoid further exposure. Wash clothing before reuse.Clean shoes thoroughly before reuse.

Get medical attention immediately. Call a poison center or physician. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If it is suspected that fumes are still present, the rescuer should wear an appropriate mask or self-contained breathing apparatus. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway.Loosen tight clothing such as a collar, tie, belt or waistband. In the event of any complaints or symptoms, avoid further exposure.

Section 4. First aid measures

Eye contact

Skin contact

Inhalation

:

:

:

Description of necessary first aid measures



Section 4. First aid measuresGet medical attention immediately. Call a poison center or physician. Wash out mouth with water. Remove dentures if any. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs, the head should be kept low so that vomit does not enter the lungs. Chemical burns must be treated promptly by a physician.Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway.Loosen tight clothing such as a collar, tie, belt or waistband.

Ingestion :

Protection of first-aiders : No action shall be taken involving any personal risk or without suitable training. If it is suspected that fumes are still present, the rescuer should wear an appropriate mask or self-contained breathing apparatus. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. Wash contaminated clothing thoroughly with water before removing it, or wear gloves.

Notes to physician : Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled.

Specific treatments : No specific treatment.

Most important symptoms/effects, acute and delayed

Inhalation : May cause respiratory irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled.

May cause burns to mouth, throat and stomach.:Ingestion

Skin contact : Causes severe burns. Toxic in contact with skin. May cause an allergic skin reaction.

Causes serious eye damage.:Eye contact

Over-exposure signs/symptoms

Skin contact

Ingestion

Inhalation Adverse symptoms may include the following:respiratory tract irritationcoughingwheezing and breathing difficultiesasthma

Adverse symptoms may include the following:stomach pains

Adverse symptoms may include the following:pain or irritationrednessblistering may occur

:

:

:

Eye contact : Adverse symptoms may include the following:painwateringredness

Potential acute health effects

See toxicological information (Section 11)

Indication of immediate medical attention and special treatment needed, if necessary

Section 5. Fire-fighting measures

Specific hazards arising from the chemical

In a fire or if heated, a pressure increase will occur and the container may burst.

Use an extinguishing agent suitable for the surrounding fire.

Extinguishing media

:

None known.


:


:



Section 5. Fire-fighting measures

Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training.

Hazardous thermal decomposition products

Decomposition products may include the following materials:carbon dioxidecarbon monoxide

Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode.

Special protective equipment for fire-fighters

:

:

Special protective actions for fire-fighters

:

Section 6. Accidental release measures

Environmental precautions

Personal precautions, protective equipment and emergency procedures

Stop leak if without risk. Move containers from spill area. Approach release from upwind.Prevent entry into sewers, water courses, basements or confined areas. Wash spillages into an effluent treatment plant or proceed as follows. Contain and collect spillage with non-combustible, absorbent material e.g. sand, earth, vermiculite or diatomaceous earth and place in container for disposal according to local regulations (see Section 13).Dispose of via a licensed waste disposal contractor. Contaminated absorbent material may pose the same hazard as the spilled product. Note: see Section 1 for emergency contact information and Section 13 for waste disposal.

:

: No action shall be taken involving any personal risk or without suitable training.Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilled material. Do not breathe vapor or mist.Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate.Put on appropriate personal protective equipment.

Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air).

Large spill :

Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor.

Small spill :

Methods and materials for containment and cleaning up

For non-emergency personnel

For emergency responders : If specialised clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel".

Section 7. Handling and storage

Advice on general occupational hygiene

Conditions for safe storage,including any incompatibilities

Eating, drinking and smoking should be prohibited in areas where this material is handled,stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures.

Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Store locked up. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination.

:

:

Protective measures Put on appropriate personal protective equipment (see Section 8). Persons with a history of skin sensitization problems or asthma, allergies or chronic or recurrent respiratory disease should not be employed in any process in which this product is used. Do not get in eyes or on skin or clothing. Do not breathe vapor or mist. Do not ingest. Use only with adequate ventilation. Wear appropriate respirator when ventilation is inadequate.Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Empty containers retain product residue and can be hazardous. Do not reuse container.

:

Precautions for safe handling



None.

Section 8. Exposure controls/personal protection

Hand protection

Use a properly fitted, air-purifying or air-fed respirator complying with an approved standard if a risk assessment indicates this is necessary. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator.

Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. Considering the parameters specified by the glove manufacturer, check during use that the gloves are still retaining their protective properties. It should be noted that the time to breakthrough for any glove material may be different for different glove manufacturers. In the case of mixtures, consisting of several substances, the protection time of the gloves cannot be accurately estimated.

Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists,gases or dusts. If contact is possible, the following protection should be worn, unless the assessment indicates a higher degree of protection: chemical splash goggles and/or face shield. If inhalation hazards exist, a full-face respirator may be required instead.

Eye/face protection

Respiratory protection :

:

:

Body protection Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.

:


: Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. In some cases,fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels.

Appropriate engineering controls

: Use only with adequate ventilation. If user operations generate dust, fumes, gas, vapor or mist, use process enclosures, local exhaust ventilation or other engineering controls to keep worker exposure to airborne contaminants below any recommended or statutory limits.

Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Contaminated work clothing should not be allowed out of the workplace. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location.

Hygiene measures :

Control parameters


Occupational exposure limits

Skin protection

Other skin protection : Appropriate footwear and any additional skin protection measures should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.

Section 9. Physical and chemical properties

Physical state

Melting point

Liquid. [Clear sparkling liquid.]

7 to 8°C (44.6 to 46.4°F)

Not available.Odor

pH

Colorless. Yellow. [Light]Color

Flash point Closed cup: 100.85°C (213.5°F)

Not available.

Not available.Odor threshold

:

:

:

:

:

:

:

Appearance

Boiling point : 213 to 214°C (415.4 to 417.2°F)

Burning rate Not applicable.:

Burning time : Not applicable.



Section 9. Physical and chemical properties

Vapor pressure

Relative density

Vapor density

Solubility

1.245

4 [Air = 1]

0.13 kPa (1 mm Hg) [room temperature]

Partially soluble in the following materials: methanol, diethyl ether and acetone.

Evaporation rate Not available.

Auto-ignition temperature Not available.

Not available.

Viscosity Not available.


:

:

:

:

:

:

:

:

Flammability (solid, gas) : Not available.

Lower and upper explosive (flammable) limits

: Not available.

SADT Not available.:

Decomposition temperature : Not available.

Solubility in water : Not available.

Section 10. Stability and reactivity

Hazardous decomposition products

Conditions to avoid No specific data.

Under normal conditions of storage and use, hazardous decomposition products should not be produced.

The product is stable.Chemical stability

No specific data.

:

:

:

Incompatible materials :

Possibility of hazardous reactions

: Under normal conditions of storage and use, hazardous reactions will not occur.

Reactivity : No specific test data related to reactivity available for this product or its ingredients.

Section 11. Toxicological information

Acute toxicity

citraconic anhydride LD50 Dermal Rabbit 218 mg/kg -LD50 Oral Rat 2600 mg/kg -

Product/ingredient name Result Species Dose Exposure

Carcinogenicity

Not available.

Mutagenicity

Not available.


Irritation/Corrosion

Not available.

Sensitization

Not available.


Classification

citraconic anhydride None. - -

Product/ingredient name NTPIARCOSHA



Section 11. Toxicological information

Not available.

Conclusion/Summary : Exposure can cause coughing, chest pains and difficulty in breathing. Exposure can cause stomach pains, vomiting and diarrhea.

Teratogenicity

Not available.

Not available.

Information on the likely routes of exposure

Inhalation : May cause respiratory irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled.

May cause burns to mouth, throat and stomach.:Ingestion

Skin contact : Causes severe burns. Toxic in contact with skin. May cause an allergic skin reaction.

Causes serious eye damage.:Eye contact

Symptoms related to the physical, chemical and toxicological characteristics

Skin contact

Ingestion

Inhalation Adverse symptoms may include the following:respiratory tract irritationcoughingwheezing and breathing difficultiesasthma

Adverse symptoms may include the following:stomach pains

Adverse symptoms may include the following:pain or irritationrednessblistering may occur

:

:

:

Eye contact : Adverse symptoms may include the following:painwateringredness

Potential chronic health effects

Delayed and immediate effects and also chronic effects from short and long term exposure

Specific target organ toxicity (single exposure)

Specific target organ toxicity (repeated exposure)

citraconic anhydride Category 3 Not applicable. Respiratory tract irritation

Name Category

Not available.

Aspiration hazard

Not available.

Route of exposure

Target organs

: Routes of entry anticipated: Oral, Dermal, Inhalation.

Potential acute health effects

Potential immediate effects

: Not available.

Short term exposure

Potential delayed effects : Not available.

Potential immediate effects

: Not available.

Long term exposure

Potential delayed effects : Not available.



Section 11. Toxicological informationOnce sensitized, a severe allergic reaction may occur when subsequently exposed to very low levels.

General :

No known significant effects or critical hazards.Carcinogenicity :

No known significant effects or critical hazards.Mutagenicity :

No known significant effects or critical hazards.Teratogenicity :

Developmental effects : No known significant effects or critical hazards.

Fertility effects : No known significant effects or critical hazards.

Numerical measures of toxicity

Not available.

Acute toxicity estimates

Section 12. Ecological information

Bioaccumulative potential

Other adverse effects : No known significant effects or critical hazards.

Not available.

Toxicity

Not available.

Persistence and degradability

Soil/water partition coefficient (KOC)

: Not available.

Mobility in soil

Not available.

Section 13. Disposal considerationsThe generation of waste should be avoided or minimized wherever possible. Disposal of this product, solutions and any by-products should at all times comply with the requirements of environmental protection and waste disposal legislation and any regional local authority requirements. Dispose of surplus and non-recyclable products via a licensed waste disposal contractor. Waste should not be disposed of untreated to the sewer unless fully compliant with the requirements of all authorities with jurisdiction.Waste packaging should be recycled. Incineration or landfill should only be considered when recycling is not feasible. This material and its container must be disposed of in a safe way. Care should be taken when handling emptied containers that have not been cleaned or rinsed out. Empty containers or liners may retain some product residues.Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers.

:Disposal methods

Section 14. Transport information

Toxic, liquids, organic, n.o.s.(citraconic anhydride)

Toxic liquid, organic, n.o.s. (citraconic anhydride)

UN2810UN2810

DOT Classification IATA

UN number

UN proper shipping name



Section 14. Transport information6.1

III

6.1

III

Packaging instructionPassenger aircraftQuantity limitation: 60 L

Cargo aircraftQuantity limitation: 220 L

-

Transport hazard class(es)

Packing group

Additional information

Environmental hazards

Special precautions for user

Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

No. No.

Transport within user’s premises: always transport in closed containers that are upright and secure. Ensure that persons transporting the product know what to do in the event of an accident or spillage.

: Not available.

:

Section 15. Regulatory informationU.S. Federal regulations

This material is not listed.Massachusetts

:

:

Clean Air Act Section 112(b) Hazardous Air Pollutants (HAPs)

: Not listed

Clean Air Act Section 602 Class I Substances

: Not listed

Clean Air Act Section 602 Class II Substances

: Not listed

DEA List I Chemicals (Precursor Chemicals)

: Not listed

DEA List II Chemicals (Essential Chemicals)

: Not listed

State regulations

TSCA 8(a) CDR Exempt/Partial exemption: Not determined

United States inventory (TSCA 8b): This material is listed or exempted.

SARA 302/304

SARA 304 RQ : Not applicable.

No products were found.

Composition/information on ingredients

SARA 311/312

Classification : Immediate (acute) health hazard

citraconic anhydride 98 - 100 No. No. No. Yes. No.

Name % Fire hazard

Sudden release of pressure

Reactive Immediate (acute)health hazard

Delayed (chronic)health hazard

Composition/information on ingredients



Section 15. Regulatory informationNew York : This material is not listed.

New Jersey : This material is not listed.

Pennsylvania : This material is not listed.

Canada inventory : This material is listed or exempted.

Australia inventory (AICS): Not determined.China inventory (IECSC): Not determined.Japan inventory: This material is listed or exempted.Korea inventory: Not determined.Malaysia Inventory (EHS Register): Not determined.New Zealand Inventory of Chemicals (NZIoC): Not determined.Philippines inventory (PICCS): This material is listed or exempted.Taiwan inventory (CSNN): Not determined.

International regulations

International lists :

Chemical Weapons Convention List Schedule I Chemicals

: Not listed

Chemical Weapons Convention List Schedule II Chemicals

: Not listed

Chemical Weapons Convention List Schedule III Chemicals

: Not listed

Section 16. Other information

6/25/2014.

History

Date of printing

Date of issue/Date of revision

:

: 6/25/2014.

Hazardous Material Information System (U.S.A.)

2

1

0

0

1

2

National Fire Protection Association (U.S.A.)

Health

Special

Instability/Reactivity

Flammability

Health

Flammability

Caution: HMIS® ratings are based on a 0-4 rating scale, with 0 representing minimal hazards or risks, and 4 representing significant hazards or risks Although HMIS® ratings are not required on SDSs under 29 CFR 1910.1200, the preparer may choose to provide them. HMIS® ratings are to be used with a fully implemented HMIS® program. HMIS® is a registered mark of the National Paint & Coatings Association (NPCA). HMIS® materials may be purchased exclusively from J. J. Keller (800) 327-6868.

The customer is responsible for determining the PPE code for this material.

Reprinted with permission from NFPA 704-2001, Identification of the Hazards of Materials for Emergency Response Copyright ©1997, National Fire Protection Association, Quincy, MA 02269. This reprinted material is not the complete and official position of the National Fire Protection Association, on the referenced subject which is represented only by the standard in its entirety.

Copyright ©2001, National Fire Protection Association, Quincy, MA 02269. This warning system is intended to be interpreted and applied only by properly trained individuals to identify fire, health and reactivity hazards of chemicals. The user is referred to certain limited number of chemicals with recommended classifications in NFPA 49 and NFPA 325, which would be used as a guideline only. Whether the chemicals are classified by NFPA or not,anyone using the 704 systems to classify chemicals does so at their own risk.

Physical hazards

Chronic Health Hazard



Section 16. Other information

Version

To the best of our knowledge, the information contained herein is accurate. However, neither the above-named supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the information contained herein.Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist.

Notice to reader

Date of previous issue

:

:

Indicates information that has changed from previously issued version.

References : Not available.

Key to abbreviations : ATE = Acute Toxicity EstimateBCF = Bioconcentration FactorGHS = Globally Harmonized System of Classification and Labelling of ChemicalsIATA = International Air Transport AssociationIBC = Intermediate Bulk ContainerIMDG = International Maritime Dangerous GoodsLogPow = logarithm of the octanol/water partition coefficientMARPOL 73/78 = International Convention for the Prevention of Pollution From Ships,1973 as modified by the Protocol of 1978. ("Marpol" = marine pollution)UN = United Nations

No previous validation.

1

SDS SpecialistPrepared by :


Sigma - T3568 Page 1 of 7





1.1 Product identifiers Product name : TrypZean®, bovine

Product Number : T3568 Brand : Sigma Index-No. : 647-010-00-7 REACH No. : A registration number is not available for this substance as the substance


CAS-No. : 9002-07-7









Classification according to Regulation (EC) No 1272/2008 Eye irritation (Category 2), H319 Specific target organ toxicity - single exposure (Category 3), H335 Skin irritation (Category 2), H315 Respiratory sensitisation (Category 1), H334


2.2 Label elements


Signal word Danger Hazard statement(s) H315 Causes skin irritation. H319 Causes serious eye irritation. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled.


H335 May cause respiratory irritation. Precautionary statement(s) P261 Avoid breathing dust. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove

contact lenses, if present and easy to do. Continue rinsing. P342 + P311 If experiencing respiratory symptoms: Call a POISON CENTER/doctor. Supplemental Hazard Statements

none

2.3 Other hazards - none


3.1 Substances Synonyms : Trypsinbovine

CAS-No. : 9002-07-7 EC-No. : 232-650-8 Index-No. : 647-010-00-7 Hazardous ingredients according to Regulation (EC) No 1272/2008


Trypsin

CAS-No. EC-No. Index-No.

9002-07-7 232-650-8 647-010-00-7

Skin Irrit. 2; Eye Irrit. 2; Resp. Sens. 1; STOT SE 3; H315, H319, H334, H335

<= 100 %







In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.













6.2 Environmental precautions Do not let product enter drains.




7.1 Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Recommended storage temperature -20 °C

Keep in a dry place. Storage class (TRGS 510): Combustible Solids







Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.


Full contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) Splash contact Material: Nitrile rubber Minimum layer thickness: 0.11 mm Break through time: 480 min Material tested:Dermatril® (KCL 740 / Aldrich Z677272, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industria situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle r (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure Do not let product enter drains.



a) Appearance Form: powder, lyophilized





No data available


No data available





No data available






No data available

p) Auto-ignition No data available


temperature


No data available









10.4 Conditions to avoid No data available


10.6 Hazardous decomposition products Hazardous decomposition products formed under fire conditions. - Nature of decomposition products not known. Other decomposition products - No data available In the event of fire: see section 5



Acute toxicity LD50 Oral - Rat - > 5,000 mg/kg(Trypsin)

Skin corrosion/irritation No data available(Trypsin)

Serious eye damage/eye irritation No data available(Trypsin)

Respiratory or skin sensitisation No data available(Trypsin)

Germ cell mutagenicity No data available(Trypsin)

Carcinogenicity



No data available(Trypsin)

Specific target organ toxicity - single exposure No data available(Trypsin)



Aspiration hazard No data available(Trypsin)

Additional Information RTECS: YN5075000 To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(Trypsin) Liver - Irregularities - Based on Human Evidence(Trypsin)





12.4 Mobility in soil No data available(Trypsin)

12.5 Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted



















H315 Causes skin irritation. H319 Causes serious eye irritation. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H335 May cause respiratory irritation.


SAFETY DATA SHEET




Page 1 of 18




Product name 1-Propanol for analysis EMSURE® ACS,Reag. Ph Eur






CAS-No. 71-23-8








India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6


number


SAFETY DATA SHEET





Page 2 of 18






Specific target organ toxicity - single exposure, Category 3, Central nervous system, H336


2.2 Label elements


Hazard pictograms

Signal word

Danger

Hazard statements



H336 May cause drowsiness or dizziness.


Prevention




Response




SAFETY DATA SHEET





Page 3 of 18

Storage



Hazard pictograms

Signal word

Danger

Hazard statements







CAS-No. 71-23-8

2.3 Other hazards

None known.


3.1 Substance

Formula CH₃CH₂CH₂OH C₃H₈O (Hill)

EC-No. 200-746-9


SAFETY DATA SHEET





Page 4 of 18




1-Propanol (<= 100 % )


71-23-8 *) Flammable liquid, Category 2, H225







3.2 Mixture

Not applicable





shower.


contact lenses.

After swallowing: caution if victim vomits. Risk of aspiration! Keep airways free. Call a physician

immediately. Subsequently administer: activated charcoal (20 - 40 g in 10% slurry).


Irritation and corrosion, Cough, respiratory paralysis, Shortness of breath, Drowsiness,

Unconsciousness, narcosis, inebriation, Vertigo, somnolence, Headache, Coma



SAFETY DATA SHEET





Page 5 of 18

Laxative: Sodium sulfate (1 tablespoon/1/4 l water).




Foam, Carbon dioxide (CO2), Dry powder




Combustible.








Further information

Remove container from danger zone and cool with water. Prevent fire extinguishing water from

contaminating surface water or the ground water system.









SAFETY DATA SHEET





Page 6 of 18
















Hygiene measures



Storage conditions

Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and

sources of ignition.




SAFETY DATA SHEET





Page 7 of 18








See section 7.1.





Eye/face protection


Hand protection

full contact:




splash contact:

Glove material: polychloroprene




89/686/EEC and the related standard EN374, for example KCL 730 Camatril® -Velours (full

contact), KCL 720 Camapren® (splash contact).



SAFETY DATA SHEET





Page 8 of 18









Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic compounds






Risk of explosion.



Form liquid

Colour colourless

Odour alcohol-like


pH 7

at 200 g/l

20 °C

Melting point -127 °C

SAFETY DATA SHEET





Page 9 of 18

Boiling point/boiling range 96.5 - 98 °C

at 1,013 hPa

Method: DIN 53171

Flash point 15 °C

Method: c.c.






at 20 °C


Density 0.80 g/cm3

at 20 °C

Method: DIN 51757



miscible in all proportions


octanol/water

log Pow: 0.25

(experimental)



SAFETY DATA SHEET





Page 10 of 18



at 20 °C



9.2 Other data


Method: DIN 51794


10.1 Reactivity






Alkaline earth metals, alcoholates

Alkali metals, Release of:, Hydrogen




Warming.


rubber, various plastics

SAFETY DATA SHEET





Page 11 of 18





Acute oral toxicity

Symptoms: Risk of aspiration upon vomiting., Aspiration may cause pulmonary oedema and

pneumonitis.





Skin irritation

Rabbit



Eye irritation

Rabbit




Sensitisation


Result: negative

(IUCLID)

Patch test: human

Result: negative

(IUCLID)


SAFETY DATA SHEET





Page 12 of 18


Ames test


Result: negative


(IUCLID)


Result: negative



Result: negative


Carcinogenicity




Teratogenicity



May cause drowsiness or dizziness.

Target Organs: Central nervous system



Aspiration hazard



Systemic effects:

Headache, Vertigo, inebriation, Unconsciousness, narcosis


respiratory paralysis, Coma

SAFETY DATA SHEET





Page 13 of 18




12.1 Toxicity

Toxicity to fish

LC50 Pimephales promelas (fathead minnow): 4,630 mg/l; 96 h

(IUCLID)

flow-through test LC50 Pimephales promelas (fathead minnow): 4,555 mg/l; 96 h




static test EC50 Daphnia magna (Water flea): 3,644 mg/l; 48 h

DIN 38412

Toxicity to algae

static test EC50 Pseudokirchneriella subcapitata (green algae): 9,170 mg/l; 48 h

(ECHA)


static test IC50 activated sludge: > 1,000 mg/l; 3 h



semi-static test NOEC Daphnia magna (Water flea): > 100 mg/l; 21 d



Biodegradability

75 %; 20 d; aerobic

(IUCLID)



2,230 mg/g

(IUCLID)

SAFETY DATA SHEET





Page 14 of 18

Theoretical oxygen demand (ThOD)

2,400 mg/g

(Lit.)

Ratio BOD/COD

73 %

(IUCLID)



log Pow: 0.25

(experimental)









SAFETY DATA SHEET





Page 15 of 18





the product itself.






14.2 Proper shipping name N-PROPANOL

14.3 Class 3




user

yes



Not relevant




14.3 Class 3



SAFETY DATA SHEET





Page 16 of 18


user

no




14.3 Class 3




user

yes

EmS F-E S-D


Not relevant




Storage class 3








Training advice

SAFETY DATA SHEET





Page 17 of 18


Labelling

Hazard pictograms

Signal word

Danger

Hazard statements





Prevention




Response




Storage




SAFETY DATA SHEET





Page 18 of 18






Page 1 of 8




Product name Sodium sulfate anhydrous EMPROVE® ESSENTIAL Ph

Eur,BP,USP,E 514






CAS-No. 7757-82-6








India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6

1.4 Notrufnummer Please contact the regional company representation in your country.




2.2 Label elements



2.3 Other hazards

None known.


3.1 Substance

Formula Na₂SO₄ Na₂O₄S (Hill)

EC-No. 231-820-9


SAFETY DATA SHEET



Product name Sodium sulfate anhydrous EMPROVE® ESSENTIAL Ph Eur,BP,USP,E 514


Page 2 of 8


1907/2006

3.2 Mixture

Not applicable





shower.




Nausea, Vomiting, cardiovascular disorders






environment.



Not combustible.



Sulphur oxides










SAFETY DATA SHEET





Page 3 of 8







of dusts.



















See section 7.1.






Hand protection

full contact:




SAFETY DATA SHEET





Page 4 of 8

splash contact:






















Form solid

Colour white

Odour odourless


pH 5.2 - 8.0

at 50 g/l

20 °C








SAFETY DATA SHEET





Page 5 of 8

Vapour pressure Not applicable


Density 2.70 g/cm³

at 20 °C



at 20 °C


octanol/water

Not applicable

Auto-ignition temperature > 400 °C

Method: NF T 20-036

does not ignite





9.2 Other data


Bulk density ca.1,400 - 1,600 kg/m³


10.1 Reactivity

See section 10.3





smelt, with, Aluminium







SAFETY DATA SHEET





Page 6 of 8



Acute oral toxicityLD50 Rat: > 2,000 mg/kg


(ECHA)

Symptoms: Possible damages:, Nausea, Vomiting







Result: slight irritation




Genotoxicity in vitroAmes test

Result: negative

(IUCLID)








Systemic effects:


cardiovascular disorders

Symptoms in:

Gastrointestinal tract



SAFETY DATA SHEET





Page 7 of 8


12.1 Toxicity

Toxicity to fishLC50 Gambusia affinis (Mosquito fish): 120 mg/l; 96 h

(IUCLID)

Toxicity to daphnia and other aquatic invertebratesEC50 Daphnia magna (Water flea): 2,564 mg/l; 48 h

(IUCLID)

Toxicity to bacteriaEC10 Pseudomonas putida: > 1,000 mg/l; 16 h

(IUCLID)





Not applicable






Additional ecological informationDischarge into the environment must be avoided.




the product itself.






regulations.


Not relevant



regulations.


SAFETY DATA SHEET





Page 8 of 8


regulations.


Not relevant








Training advice




laws.




SAFETY DATA SHEET




Page 1 of 11




Product name di-Sodium hydrogen phosphate anhydrous EMPROVE® ESSENTIAL

Ph Eur,BP,USP,JPE,E 339






CAS-No. 7558-79-4








India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6


number





SAFETY DATA SHEET



Product name di-Sodium hydrogen phosphate anhydrous EMPROVE® ESSENTIAL Ph

Eur,BP,USP,JPE,E 339


Page 2 of 11

2.2 Label elements



2.3 Other hazards

None known.


3.1 Substance

Formula Na₂HPO₄ HNa₂O₄P (Hill)

EC-No. 231-448-7



1907/2006.

3.2 Mixture

Not applicable





shower.

After eye contact: rinse out with plenty of water with the eyelid held wide open. Call in

ophthalmologist if necessary.



SAFETY DATA SHEET






Page 3 of 11

irritant effects







environment.




Not combustible.



Oxides of phosphorus




Further information











SAFETY DATA SHEET






Page 4 of 11




of dusts.







Hygiene measures



Storage conditions












See section 7.1.

SAFETY DATA SHEET






Page 5 of 11





Eye/face protection

Safety glasses

Hand protection

full contact:




splash contact:





















SAFETY DATA SHEET






Page 6 of 11



Form solid

Colour white

Odour odourless


pH 8.7 - 9.3

at 10 g/l

20 °C


(decomposition)










SAFETY DATA SHEET






Page 7 of 11



at 20 °C


octanol/water





Explosive properties Not applicable


9.2 Other data




10.1 Reactivity

See section 10.3


hygroscopic



Strong acids, antipyrine, acetates



SAFETY DATA SHEET






Page 8 of 11







Acute oral toxicity

LD50 Rat: > 2,000 mg/kg






Skin irritation

Rabbit



After long-term exposure to the chemical: slight irritation

Eye irritation

After long-term exposure to the chemical: slight irritation

Sensitisation




Ames test


Result: negative


Carcinogenicity


SAFETY DATA SHEET






Page 9 of 11



Teratogenicity






Aspiration hazard






12.1 Toxicity

Toxicity to fish


(Lit.)


EC50 Daphnia magna (Water flea): 1,089 mg/l; 48 h

(Lit.)












SAFETY DATA SHEET






Page 10 of 11





the product itself.






regulations.


Not relevant



regulations.



regulations.


Not relevant





SAFETY DATA SHEET






Page 11 of 11




Training advice






SAFETY DATA SHEET




Page 1 of 12




Product name Glycine cryst. suitable for use as excipient EMPROVE® exp

Ph.Eur.,BP,JP,USP






CAS-No. 56-40-6


Identified uses Food and pharmaceutical industry






India * Tel: 0091 22 6210 9000



Tel : +91-2267863131-6


number





SAFETY DATA SHEET



Product name Glycine cryst. suitable for use as excipient EMPROVE® exp Ph.Eur.,BP,JP,USP


Page 2 of 12

2.2 Label elements



2.3 Other hazards

None known.


3.1 Substance

Formula H₂NCH₂COOH C₂H₅NO₂ (Hill)

EC-No. 200-272-2



1907/2006.

3.2 Mixture

Not applicable





shower.





SAFETY DATA SHEET





Page 3 of 12










Combustible.



nitrous gases, nitrogen oxides




Further information












SAFETY DATA SHEET





Page 4 of 12



of dusts.







Hygiene measures



Storage conditions












See section 7.1.

SAFETY DATA SHEET





Page 5 of 12





Eye/face protection

Safety glasses

Hand protection

full contact:




splash contact:





















SAFETY DATA SHEET





Page 6 of 12



Form solid

Colour white

Odour odourless


pH 5.9 - 6.4

at 50 g/l

20 °C


(decomposition)





Test N.1: Test method for readily combustible solids



Vapour pressure 0.0000171 Pa

at 25 °C


SAFETY DATA SHEET





Page 7 of 12

Density 1.161 g/cm3

at 20 °C



at 25 °C

soluble


octanol/water

log Pow: -3.21

(calculated)


Auto-ignition temperature not auto-flammable


Viscosity, dynamic Not applicable



9.2 Other data

Bulk density 920 kg/m3

Particle size < 0.1 mm



10.1 Reactivity



assumed.



SAFETY DATA SHEET





Page 8 of 12



Strong oxidizing agents, Bases









Acute oral toxicity


(External MSDS)





Skin irritation


Eye irritation


Sensitisation

Sensitisation test: Mouse

Result: negative



SAFETY DATA SHEET





Page 9 of 12


reverse mutation assay


Result: negative



Mouse lymphoma test

Result: negative


Ames test


Result: negative


(National Toxicology Program)

Carcinogenicity




Teratogenicity






Aspiration hazard



This is a non-essential amino acid that occurs in many forms in natural protein.

Therapeutically used substance.

No toxic effects are to be expected when the product is handled appropriately.



SAFETY DATA SHEET





Page 10 of 12

12.1 Toxicity

Toxicity to fish

static test LC50 Oryzias latipes (Orange-red killifish): > 1,000 mg/l; 96 h



semi-static test EC50 Daphnia magna (Water flea): > 220 mg/l; 48 h



Toxicity to algae

static test EC50 Pseudokirchneriella subcapitata (green algae): > 1,000 mg/l; 72 h



static test NOEC activated sludge: >= 100 mg/l; 14 d

(ECHA)


Biodegradability

76 - 82 %; 14 d; aerobic

OECD Test Guideline 301C




log Pow: -3.21

(calculated)








SAFETY DATA SHEET





Page 11 of 12





the product itself.






regulations.


Not relevant



regulations.



regulations.


Not relevant






SAFETY DATA SHEET





Page 12 of 12



Training advice







SDS_US - SDSMIX000331 1/11

SAFETY DATA SHEET According to US Regulation 29 CFR 1910.1200 (HazCom 2012)

1. Identification

Product identifier: Phosphoric Acid


Synonyms: Ortho-Phosphoric Acid, White Phosphoric Acid Product No.: 0240, 6908, 2798, 2797, 5854, 2796, 5804, 2788, 0259, 5372,

0274, 0269, 0268, 0265, 0264, 0262, 0260, 0255, 0251, 6168

Recommended restrictions

Recommended use: For Laboratory, Research or Manufacturing Use. Restrictions on use: Not determined.


Manufacturer

Company Name: Avantor Performance Materials, LLC. Address: 3477 Corporate Parkway

Center Valley, PA 18034

Telephone: Customer Service: 855-282-6867

Fax: 610-573-2610 Contact Person: Environmental Health & Safety E-mail: [email protected]

Emergency telephone number: CHEMTREC: 1-800-424-9300 within US and Canada

2. Hazard(s) identification

Hazard Classification

Physical Hazards

Corrosive to metals Category 1

Health Hazards

Acute toxicity (Oral) Category 4

Acute toxicity (Dermal) Category 5

Skin Corrosion/Irritation Category 1A

Serious Eye Damage/Eye Irritation Category 1


Category 31.

Target Organs

1. Respiratory tract irritation.

Unknown toxicity - Health

Acute toxicity, oral 0 %

Acute toxicity, dermal 0 %

Acute toxicity, inhalation, vapor 84 %



Acute toxicity, inhalation, dust or mist

84 %

Hazard Symbol:

Signal Word: Danger

Hazard Statement: May be corrosive to metals. Harmful if swallowed. Causes severe skin burns and eye damage. May cause respiratory irritation.

Precautionary Statements

Prevention: Keep only in original packaging. Do not breathe dust/fume/mist/vapors. Do

not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling.

Response: Absorb spillage to prevent material damage. IF SWALLOWED: Rinse

mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower]. Wash contaminated clothing before reuse. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER or doctor/physician.

Storage: Store locked up. Store in a well-ventilated place. Keep container tightly

closed. Store in a corrosion-resistant container with a resistant inner liner.

Disposal: Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Hazard(s) not otherwise classified (HNOC):

None.

3. Composition/information on ingredients

Mixtures

Chemical Identity CAS number Content in percent (%)*

Phosphoric acid 7664-38-2 80 - 90% * All concentrations are percent by weight unless ingredient is a gas. Gas concentrations are in percent by volume.


Label Elements



General information: Get medical advice/attention if you feel unwell. Show this safety data sheet

to the doctor in attendance. Ingestion: Do NOT induce vomiting. Call a physician or poison control center

immediately. If vomiting occurs, keep head low so that stomach content doesn't get into the lungs.

Inhalation: Move to fresh air. Call a physician or poison control center immediately.

Apply artificial respiration if victim is not breathing If breathing is difficult, give oxygen.

Skin Contact: Immediately flush with plenty of water for at least 15 minutes while

removing contaminated clothing and shoes. Call a physician or poison control center immediately. Wash contaminated clothing before reuse. Destroy or thoroughly clean contaminated shoes.

Eye contact: Immediately flush with plenty of water for at least 15 minutes. If easy to do,

remove contact lenses. Call a physician or poison control center immediately. In case of irritation from airborne exposure, move to fresh air. Get medical attention immediately.

Most important symptoms/effects, acute and delayed

Symptoms: Causes severe skin and eye burns. Causes digestive tract burns.

Hazards: None known.

Indication of immediate medical attention and special treatment needed

Treatment: Treat symptomatically. Symptoms may be delayed.

5. Fire-fighting measures

General Fire Hazards: Product is highly acidic. Wear protective gear if spilled during fire fighting.

Suitable (and unsuitable) extinguishing media

Suitable extinguishing media:

The product is non-combustible. Use fire-extinguishing media appropriate for surrounding materials.

Unsuitable extinguishing media:

None known.

Specific hazards arising from

the chemical: Not combustible, but if involved in a fire decomposes to produce toxic gases.

Special protective equipment and precautions for firefighters

Special fire fighting procedures:

Move containers from fire area if you can do so without risk. Use water spray to keep fire-exposed containers cool. Cool containers exposed to flames with water until well after the fire is out.

Special protective equipment for fire-fighters:

Firefighters must use standard protective equipment including flame retardant coat, helmet with face shield, gloves, rubber boots, and in enclosed spaces, SCBA. Product is highly acidic. Wear protective gear if spilled during fire fighting.

6. Accidental release measures



Personal precautions,

protective equipment and emergency procedures:

See Section 8 of the SDS for Personal Protective Equipment. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Keep unauthorized personnel away. Keep upwind. Ventilate closed spaces before entering them.

Methods and material for

containment and cleaning up:

Neutralize with lime or soda ash. Absorb spill with vermiculite or other inert material, then place in a container for chemical waste. Clean surface thoroughly to remove residual contamination. Dike far ahead of larger spill for later recovery and disposal.

Notification Procedures: Inform authorities if large amounts are involved.

Environmental Precautions: Do not contaminate water sources or sewer. Prevent further leakage or

spillage if safe to do so.

7. Handling and storage

Precautions for safe handling: Do not get in eyes, on skin, on clothing. Do not taste or swallow. Wash

thoroughly after handling. Do not eat, drink or smoke when using the product. Use caution when adding this material to water. Add material slowly when mixing with water. Do not add water to the material; instead, add the material to the water.

Conditions for safe storage,

including any incompatibilities:

Do not store in metal containers. Keep container tightly closed. Store in a well-ventilated place.

8. Exposure controls/personal protection

Control Parameters

Occupational Exposure Limits

Chemical Identity Type Exposure Limit Values Source

Phosphoric acid TWA 1 mg/m3 US. ACGIH Threshold Limit Values (2011)

STEL 3 mg/m3 US. ACGIH Threshold Limit Values (2011)

REL 1 mg/m3 US. NIOSH: Pocket Guide to Chemical Hazards (2010)

STEL 3 mg/m3 US. NIOSH: Pocket Guide to Chemical Hazards (2010)

PEL 1 mg/m3 US. OSHA Table Z-1 Limits for Air Contaminants (29 CFR 1910.1000) (02 2006)

TWA 1 mg/m3 US. OSHA Table Z-1-A (29 CFR 1910.1000) (1989)

STEL 3 mg/m3 US. OSHA Table Z-1-A (29 CFR 1910.1000) (1989)

TWA 1 mg/m3 US. Tennessee. OELs. Occupational Exposure Limits, Table Z1A (06 2008)

STEL 3 mg/m3 US. Tennessee. OELs. Occupational Exposure Limits, Table Z1A (06 2008)

ST ESL 10 µg/m3 US. Texas. Effects Screening Levels (Texas Commission on Environmental Quality) (12 2010)

AN ESL 1 µg/m3 US. Texas. Effects Screening Levels (Texas Commission on Environmental Quality) (12 2010)

TWA PEL 1 mg/m3 US. California Code of Regulations, Title 8, Section 5155. Airborne Contaminants (08 2010)

STEL 3 mg/m3 US. California Code of Regulations, Title 8, Section 5155. Airborne Contaminants (08 2010)



Appropriate Engineering Controls

No data available.

Individual protection measures, such as personal protective equipment

General information: Good general ventilation (typically 10 air changes per hour) should be used.

Ventilation rates should be matched to conditions. If applicable, use process enclosures, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits. If exposure limits have not been established, maintain airborne levels to an acceptable level. An eye wash and safety shower must be available in the immediate work area.

Eye/face protection: Wear safety glasses with side shields (or goggles) and a face shield.

Skin Protection

Hand Protection: Chemical resistant gloves

Other: Wear suitable protective clothing and gloves.

Respiratory Protection: In case of inadequate ventilation use suitable respirator. Respirator type: Chemical respirator with acid gas cartridge.

Hygiene measures: Provide eyewash station and safety shower. Observe good industrial

hygiene practices. Wash hands before breaks and immediately after handling the product. Wash contaminated clothing before reuse. Avoid contact with eyes. Avoid contact with skin.

9. Physical and chemical properties

Appearance

Physical state: Liquid

Form: Liquid

Color: Colorless

Odor: Odorless

Odor threshold: No data available.

pH: 1.5 (3.27 g/l, 20 °C)

Melting point/freezing point: 21.1 °C

Initial boiling point and boiling range: 158 °C

Flash Point: not applicable

Evaporation rate: No data available.

Flammability (solid, gas): No data available.

Upper/lower limit on flammability or explosive limits

Flammability limit - upper (%): No data available.

Flammability limit - lower (%): No data available.

Explosive limit - upper (%): No data available.

Explosive limit - lower (%): No data available.

Vapor pressure: 0.3 kPa

Vapor density: No data available.

Density: 1.69 g/ml (20 °C)

Relative density: 1.69 (20 °C)

Solubility(ies)

Solubility in water: Miscible with water.

Solubility (other): No data available.



Partition coefficient (n-octanol/water): No data available.

Auto-ignition temperature: No data available.

Decomposition temperature: No data available.

Viscosity: No data available.


Reactivity: No dangerous reaction known under conditions of normal use.

Chemical Stability: Material is stable under normal conditions.

Possibility of hazardous

reactions: Hazardous polymerization does not occur.

Conditions to avoid: Avoid contact with oxidizing agents. Avoid contact with strong reducing

agents. Contact with alkalis. Incompatible Materials: Strong reducing agents. Alkalies. Strong oxidizing agents. Metals.

Hazardous Decomposition

Products: oxides of phosphorus

11. Toxicological information

Information on likely routes of exposure

Inhalation: Severely irritating to respiratory system.

Skin Contact: Causes severe skin burns.

Eye contact: Causes serious eye damage.

Ingestion: Harmful if swallowed.


Acute toxicity (list all possible routes of exposure)

Oral Product: ATEmix (Rat): 1,700 mg/kg

Dermal

Product: ATEmix (Rabbit) 3,044.44 mg/kg

Inhalation Product: Not classified for acute toxicity based on available data.

Repeated dose toxicity Product: No data available.

Skin Corrosion/Irritation Product: Causes severe skin burns.

Serious Eye Damage/Eye Irritation

Product: Causes serious eye damage.



Respiratory or Skin Sensitization Product: Not a skin sensitizer.

Carcinogenicity

Product: This substance has no evidence of carcinogenic properties.

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: No carcinogenic components identified

US. National Toxicology Program (NTP) Report on Carcinogens: No carcinogenic components identified

US. OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050): No carcinogenic components identified

Germ Cell Mutagenicity

In vitro Product: No mutagenic components identified

In vivo

Product: No mutagenic components identified

Reproductive toxicity Product: No components toxic to reproduction


Product: None known.

Specific Target Organ Toxicity - Repeated Exposure Product: None known.

Target Organs Specific Target Organ Toxicity - Single Exposure: Respiratory tract irritation.

Aspiration Hazard

Product: Not classified

Other effects: Not known.

12. Ecological information

Ecotoxicity:

Acute hazards to the aquatic environment:




Chronic hazards to the aquatic environment:






Toxicity to Aquatic Plants Product: No data available.

Persistence and Degradability

Biodegradation

Product: Expected to be readily biodegradable.

BOD/COD Ratio Product: No data available.

Bioaccumulative potential

Bioconcentration Factor (BCF) Product: No data available on bioaccumulation.

Partition Coefficient n-octanol / water (log Kow)

Product: No data available. Mobility in soil: The product is water soluble and may spread in water systems.

Other adverse effects: The product may affect the acidity (pH-factor) in water with risk of harmful

effects to aquatic organisms.

13. Disposal considerations

Disposal instructions: Discharge, treatment, or disposal may be subject to national, state, or local

laws. Contaminated Packaging: Since emptied containers retain product residue, follow label warnings even

after container is emptied.


DOT

UN Number: UN 1805 UN Proper Shipping Name: Phosphoric acid solution Transport Hazard Class(es)

Class: 8 Label(s): 8

Packing Group: III Marine Pollutant: No Special precautions for user: Not determined.

IMDG

UN Number: UN 1805 UN Proper Shipping Name: PHOSPHORIC ACID SOLUTION Transport Hazard Class(es)

Class: 8 Label(s): 8 EmS No.: F-A, S-B

Packing Group: III Marine Pollutant: No



Special precautions for user: Not determined.

IATA UN Number: UN 1805 Proper Shipping Name: Phosphoric acid, solution Transport Hazard Class(es):

Class: 8 Label(s): 8

Packing Group: III Marine Pollutant: No Special precautions for user: Not determined.


US Federal Regulations

TSCA Section 12(b) Export Notification (40 CFR 707, Subpt. D) None present or none present in regulated quantities.

US. OSHA Specifically Regulated Substances (29 CFR 1910.1001-1050)


CERCLA Hazardous Substance List (40 CFR 302.4):

Chemical Identity Reportable quantity Phosphoric acid 5000 lbs.

Superfund Amendments and Reauthorization Act of 1986 (SARA)

Hazard categories

Corrosive to metals Acute toxicity Skin Corrosion/Irritation Serious Eye Damage/Eye Irritation Specific Target Organ Toxicity - Single Exposure

SARA 302 Extremely Hazardous Substance


SARA 304 Emergency Release Notification Chemical Identity Reportable quantity Phosphoric acid 5000 lbs.

SARA 311/312 Hazardous Chemical Chemical Identity Threshold Planning Quantity Phosphoric acid 10000 lbs.

SARA 313 (TRI Reporting) None present or none present in regulated quantities.

Clean Air Act (CAA) Section 112(r) Accidental Release Prevention (40 CFR 68.130):

None present or none present in regulated quantities. Clean Water Act Section 311 Hazardous Substances (40 CFR 117.3):

Chemical Identity Reportable quantity Phosphoric acid Reportable quantity: 5000 lbs.

US State Regulations



US. California Proposition 65 No ingredient regulated by CA Prop 65 present.

US. New Jersey Worker and Community Right-to-Know Act

Chemical Identity Phosphoric acid

US. Massachusetts RTK - Substance List


US. Pennsylvania RTK - Hazardous Substances


US. Rhode Island RTK


International regulations

Montreal protocol

not applicable

Stockholm convention

not applicable

Rotterdam convention

not applicable

Kyoto protocol not applicable

Inventory Status:

Australia AICS: On or in compliance with the inventory Canada DSL Inventory List: On or in compliance with the inventory EINECS, ELINCS or NLP: On or in compliance with the inventory Japan (ENCS) List: On or in compliance with the inventory Korea Existing Chemicals Inv. (KECI): On or in compliance with the inventory Philippines PICCS: On or in compliance with the inventory US TSCA Inventory: On or in compliance with the inventory New Zealand Inventory of Chemicals: On or in compliance with the inventory China Inv. Existing Chemical Substances: On or in compliance with the inventory Mexico INSQ: On or in compliance with the inventory Taiwan Chemical Substance Inventory: On or in compliance with the inventory

16.Other information, including date of preparation or last revision



0

1

3

NFPA Hazard ID

Flammability

Health

Reactivity

Special hazard.

Hazard rating: 0 - Minimal; 1 - Slight; 2 - Moderate; 3 - Serious; 4 - Severe; RNP - Rating not possible

Issue Date: 12-01-2017

Revision Information: Not relevant.

Version #: 1.3

Further Information: No data available.

Disclaimer: The information provided in this Safety Data Sheet (SDS) was prepared based on data believed to be accurate as of the date of this SDS. TO THE GREATEST EXTENT PERMITTED BY LAW, AVANTOR PERFORMANCE MATERIALS (“AVANTOR”) EXPRESSLY DISCLAIMS ANY AND ALL REPRESENTATIONS AND WARRANTIES REGARDING THE INFORMATION CONTAINED HEREIN INCLUDING, WITHOUT LIMITATION, AS TO ACCURACY, COMPLETENESS, FITNESS FOR PURPOSE OR USE, MERCHANTABILITY, NON-INFRINGEMENT, PERFORMANCE, SAFETY, SUITABILITY AND STABILITY. This SDS is intended as a guide to the appropriate use, handling, storage and disposal of the product to which it relates by properly trained personnel, and is not intended to be comprehensive. Users of Avantor’s products are advised to perform their own tests and to exercise their own judgment to determine the safety, suitability and appropriate use, handling, storage and disposal of each product and product combination for their own purposes and uses. TO THE GREATEST EXTENT PERMITTED BY LAW, AVANTOR DISCLAIMS LIABILITY FOR, AND BY USING AVANTOR’S PRODUCTS PURCHASER AGREES THAT UNDER NO CIRCUMSTANCES SHALL AVANTOR BE LIABLE FOR, SPECIAL, INDIRECT, INCIDENTAL , PUNITIVE OR CONSEQUENTIAL DAMAGES OF ANY TYPE OR KIND, INCLUDING WITHOUT LIMITATION, FOR LOSS OF PROFITS, REPUTATIONAL DAMAGE, PRODUCT RECALL OR BUSINESS INTERRUPTION.

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