List of Publications | Dr Marie-Paule Kieny 1 | P a g e

List of Publications Dr Marie-Paule Kieny Assistant Director-General Health Systems and Innovation World Health Organization

As of 15 March 2017

2017

Sutter RW, Okayasu H, Kieny MP. Next generation inactivated poliovirus vaccine: The future has arrived. Clin Infect Dis. 2017 Feb 14. doi: 10.1093/cid/cix116. [Epub ahead of print] PubMed PMID: 28200099. Zhang W, Hirve S, Kieny MP. Seasonal vaccines - Critical path to pandemic influenza response. Vaccine. 2017 Feb 7;35(6):851-852. doi: 10.1016/j.vaccine.2016.12.056. PubMed PMID: 28087149; PubMed Central PMCID: PMC5287218. Henao-Restrepo AM, Camacho A, Longini IM, Watson CH, Edmunds WJ, Egger M, Carroll MW, Dean NE, Diatta I, Doumbia M, Draguez B, Duraffour S, Enwere G, Grais R, Gunther S, Gsell PS, Hossmann S, Watle SV, Kondé MK, Kéïta S, Kone S, Kuisma E, Levine MM, Mandal S, Mauget T, Norheim G, Riveros X, Soumah A, Trelle S, Vicari AS, Røttingen JA, Kieny MP. Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!). Lancet. 2017 Feb 4;389(10068):505-518. doi: 10.1016/S0140-6736(16)32621-6. PubMed PMID: 28017403. Hill S, Kieny MP. Towards access 2030. Lancet. 2017 Jan 28;389(10067):341-343. doi: 10.1016/S0140-6736(16)31904-3. PubMed PMID: 27832875.

2016

Bertram MY, Lauer JA, De Joncheere K, Edejer T, Hutubessy R, Kieny MP, Hill SR. Cost-effectiveness thresholds: pros and cons. Bull World Health Organ. 2016 Dec 1;94(12):925-930. PubMed PMID: 27994285; PubMed Central PMCID: PMC5153921. Hombach J, Friede M, Moorphy V, Costello A, Kieny MP. Developing a vaccine against Zika. BMJ. 2016 Nov 10;355:i5923. doi: 10.1136/bmj.i5923. PubMed PMID: 27834272; PubMed Central PMCID: PMC5104272. Kieny MP, Rägo L. Regulatory policy for research and development of vaccines for public health emergencies. Expert Rev Vaccines. 2016 Sep;15(9):1075-7. doi: 10.1080/14760584.2016.1188695. PubMed PMID: 27181597. Kieny MP, Rottingen JA, Farrar J; WHO R&D Blueprint team.; R&D Blueprint Scientific Advisory Group.. The need for global R&D coordination for infectious diseases with epidemic potential. Lancet. 2016 Jul 30;388(10043):460-1. doi: 10.1016/S0140-6736(16)31152-7. PubMed PMID: 27507751.

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Modjarrad K, Moorthy VS, Ben Embarek P, Van Kerkhove M, Kim J, Kieny MP. A roadmap for MERS-CoV research and product development: report from a World Health Organization consultation. Nat Med. 2016 Jul 7;22(7):701-5. doi: 10.1038/nm.4131. PubMed PMID: 27387881. Chalkidou K, Glassman A, Marten R, Vega J, Teerawattananon Y, Tritasavit N, Gyansa-Lutterodt M, Seiter A, Kieny MP, Hofman K, Culyer AJ. Priority-setting for achieving universal health coverage. Bull World Health Organ. 2016 Jun 1;94(6):462-7. doi: 10.2471/BLT.15.155721. PubMed PMID: 27274598; PubMed Central PMCID: PMC4890204. Kieny MP, Moorthy V, Bagozzi D. Public health: Use open data to curb Zika virus. Nature. 2016 May 26;533(7604):469. doi: 10.1038/533469b. PubMed PMID: 27225109. Haug CJ, Kieny MP, Murgue B. The Zika Challenge. N Engl J Med. 2016 May 12;374(19):1801-3. doi: 10.1056/NEJMp1603734. PubMed PMID: 27028782. Agnandji ST, Huttner A, Zinser ME, Njuguna P, Dahlke C, Fernandes JF, Yerly S, Dayer JA, Kraehling V, Kasonta R, Adegnika AA, Altfeld M, Auderset F, Bache EB, Biedenkopf N, Borregaard S, Brosnahan JS, Burrow R, Combescure C, Desmeules J, Eickmann M, Fehling SK, Finckh A, Goncalves AR, Grobusch MP, Hooper J, Jambrecina A, Kabwende AL, Kaya G, Kimani D, Lell B, Lemaître B, Lohse AW, Massinga-Loembe M, Matthey A, Mordmüller B, Nolting A, Ogwang C, Ramharter M, Schmidt-Chanasit J, Schmiedel S, Silvera P, Stahl FR, Staines HM, Strecker T, Stubbe HC, Tsofa B, Zaki S, Fast P, Moorthy V, Kaiser L, Krishna S, Becker S, Kieny MP, Bejon P, Kremsner PG, Addo MM, Siegrist CA. Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe. N Engl J Med. 2016 Apr 28;374(17):1647-60. doi: 10.1056/NEJMoa1502924. PubMed PMID: 25830326. Kieny MP, Longini IM, Henao-Restrepo AM, Watson CH, Egger M, Edmunds WJ. Changes in the primary outcome in Ebola vaccine trial--Authors' reply. Lancet. 2016 Apr 9;387(10027):1509-10. doi: 10.1016/S0140-6736(16)00686-3. PubMed PMID: 27115974. Moorthy VS, Roth C, Olliaro P, Dye C, Kieny MP. Best practices for sharing information through data platforms: establishing the principles. Bull World Health Organ. 2016 Apr 1;94(4):234-234A. doi: 10.2471/BLT.16.172882. PubMed PMID: 27034512; PubMed Central PMCID: PMC4794314. Henao-Restrepo AM, Preziosi MP, Wood D, Moorthy V, Kieny MP; WHO Ebola Research, Development Team.. On a path to accelerate access to Ebola vaccines: The WHO's research and development efforts during the 2014-2016 Ebola epidemic in West Africa. Curr Opin Virol. 2016 Apr;17:138-44. doi: 10.1016/j.coviro.2016.03.008. Review. PubMed PMID: 27180074. Kieny MP, Viergever RF, Adam T, Boerma T, Røttingen JA. Global platform to inform investments for health R&D. Lancet. 2016 Mar 19;387(10024):1157. doi: 10.1016/S0140-6736(16)00705-4. PubMed PMID: 27025327. Dye C, Bartolomeos K, Moorthy V, Kieny MP. Data sharing in public health emergencies: a call to researchers. Bull World Health Organ. 2016 Mar 1;94(3):158. doi: 10.2471/BLT.16.170860. PubMed PMID: 26966322; PubMed Central PMCID: PMC4773943. De Santis O, Audran R, Pothin E, Warpelin-Decrausaz L, Vallotton L, Wuerzner G, Cochet C, Estoppey D, Steiner-Monard V, Lonchampt S, Thierry AC, Mayor C, Bailer RT, Mbaya OT, Zhou Y, Ploquin A, Sullivan NJ, Graham BS, Roman F, De Ryck I, Ballou WR, Kieny MP, Moorthy V, Spertini F, Genton B. Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a

List of Publications | Dr Marie-Paule Kieny 3 | P a g e

randomised, double-blind, placebo-controlled, dose-finding, phase 1/2a study. Lancet Infect Dis. 2016 Mar;16(3):311-20. doi: 10.1016/S1473-3099(15)00486-7. PubMed PMID: 26725450. Rudenko L, Isakova-Sivak I, Naykhin A, Kiseleva I, Stukova M, Erofeeva M, Korenkov D, Matyushenko V, Sparrow E, Kieny MP. H7N9 live attenuated influenza vaccine in healthy adults: a randomised, double-blind, placebo-controlled, phase 1 trial. Lancet Infect Dis. 2016 Mar;16(3):303-10. doi: 10.1016/S1473-3099(15)00378-3. PubMed PMID: 26673391. Modjarrad K, Moorthy VS, Millett P, Gsell PS, Roth C, Kieny MP. Developing Global Norms for Sharing Data and Results during Public Health Emergencies. PLoS Med. 2016 Jan 5;13(1):e1001935. doi: 10.1371/journal.pmed.1001935. Review. PubMed PMID: 26731342; PubMed Central PMCID: PMC4701443. Tapia MD, Sow SO, Lyke KE, Haidara FC, Diallo F, Doumbia M, Traore A, Coulibaly F, Kodio M, Onwuchekwa U, Sztein MB, Wahid R, Campbell JD, Kieny MP, Moorthy V, Imoukhuede EB, Rampling T, Roman F, De Ryck I, Bellamy AR, Dally L, Mbaya OT, Ploquin A, Zhou Y, Stanley DA, Bailer R, Koup RA, Roederer M, Ledgerwood J, Hill AV, Ballou WR, Sullivan N, Graham B, Levine MM. Use of ChAd3-EBO-Z Ebola virus vaccine in Malian and US adults, and boosting of Malian adults with MVA-BN-Filo: a phase 1, single-blind, randomised trial, a phase 1b, open-label and double-blind, dose-escalation trial, and a nested, randomised, double-blind, placebo-controlled trial. Lancet Infect Dis. 2016 Jan;16(1):31-42. doi: 10.1016/S1473-3099(15)00362-X. PubMed PMID: 26546548; PubMed Central PMCID: PMC4700389.

2015

Tiffay K, Jodar L, Kieny MP, Socquet M, LaForce FM. The Evolution of the Meningitis Vaccine Project. Clin Infect Dis. 2015 Nov 15;61 Suppl 5:S396-403. doi: 10.1093/cid/civ594. Review. PubMed PMID: 26553666; PubMed Central PMCID: PMC4639496. Huttner A, Dayer JA, Yerly S, Combescure C, Auderset F, Desmeules J, Eickmann M, Finckh A, Goncalves AR, Hooper JW, Kaya G, Krähling V, Kwilas S, Lemaître B, Matthey A, Silvera P, Becker S, Fast PE, Moorthy V, Kieny MP, Kaiser L, Siegrist CA; VSV-Ebola Consortium.. The effect of dose on the safety and immunogenicity of the VSV Ebola candidate vaccine: a randomised double-blind, placebo-controlled phase 1/2 trial. Lancet Infect Dis. 2015 Oct;15(10):1156-66. doi: 10.1016/S1473-3099(15)00154-1. PubMed PMID: 26248510. Bishai D, Ghaffar A, Kelley E, Kieny MP. Honouring the value of people in public health: a different kind of p-value. Bull World Health Organ. 2015 Sep 1;93(9):661-2. doi: 10.2471/BLT.14.149369. PubMed PMID: 26478631; PubMed Central PMCID: PMC4581643. Henao-Restrepo AM, Longini IM, Egger M, Dean NE, Edmunds WJ, Camacho A, Carroll MW, Doumbia M, Draguez B, Duraffour S, Enwere G, Grais R, Gunther S, Hossmann S, Kondé MK, Kone S, Kuisma E, Levine MM, Mandal S, Norheim G, Riveros X, Soumah A, Trelle S, Vicari AS, Watson CH, Kéïta S, Kieny MP, Røttingen JA. Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial. Lancet. 2015 Aug 29;386(9996):857-66. doi: 10.1016/S0140-6736(15)61117-5. PubMed PMID: 26248676. Magrini N, Robertson J, Forte G, Cappello B, Moja LP, de Joncheere K, Kieny MP. Tough decisions on essential medicines in 2015. Bull World Health Organ. 2015 Apr 1;93(4):283-4. doi: 10.2471/BLT.15.154385. PubMed PMID: 26229193; PubMed Central PMCID: PMC4431566.

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Schenkelberg T, Kieny MP, Bianco AE, Koff WC. Building the Human Vaccines Project: strategic management recommendations and summary report of the 15-16 July 2014 business workshop. Expert Rev Vaccines. 2015 May;14(5):629-36. doi: 10.1586/14760584.2015.1013466. Epub 2015 Feb 11. PubMed PMID: 25673514. Agnandji ST et al. Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe - Preliminary Report. N Engl J Med. 2015 Apr 1. [Epub ahead of print] PubMed PMID: 25830326. Moorthy VS, Karam G, Vannice KS, Kieny MP. Rationale for WHO's new position calling for prompt reporting and public disclosure of interventional clinical trial results. PLoS Med. 2015 Apr 14;12(4):e1001819. doi: 10.1371/journal.pmed.1001819. eCollection 2015 Apr. PubMed PMID: 25874642; PubMed Central PMCID: PMC4396122. Adam T, Røttingen JA, Kieny MP. Informing the establishment of the WHO Global Observatory on Health Research and Development: a call for papers. Health Res Policy Syst. 2015 Feb 2;13(1):9. doi: 10.1186/1478-4505-13-9. PubMed PMID: 25645000; PubMed Central PMCID: PMC4328039. Kieny MP, Dovlo D. Beyond Ebola: a new agenda for resilient health systems. Lancet. 2015 Jan 10;385(9963):91-2. doi: 10.1016/S0140-6736(14)62479-X. PubMed PMID: 25706456.

2014

Kanapathipillai R, Henao Restrepo AM, Fast P, Wood D, Dye C, Kieny MP, Moorthy V. Ebola vaccine--an urgent international priority. N Engl J Med. 2014 Dec 11;371(24):2249-51. doi: 10.1056/NEJMp1412166. Epub 2014 Oct 7. PubMed PMID: 25289888. Ghaffar A, Tran N, Røttingen JA, Kieny MP. Health policy and systems research: building momentum and community. Bull World Health Organ. 2014 Dec 1;92(12):851. doi: 10.2471/BLT.14.149393. PubMed PMID: 25552766; PubMed Central PMCID: PMC4264400. Kieny MP, Evans DB, Schmets G, Kadandale S. Health-system resilience: reflections on the Ebola crisis in western Africa. Bull World Health Organ. 2014 Dec 1;92(12):850. doi: 10.2471/BLT.14.149278. PubMed PMID: 25552765; PubMed Central PMCID: PMC4264399. Briand S, Bertherat E, Cox P, Formenty P, Kieny MP, Myhre JK, Roth C, Shindo N, Dye C. The international Ebola emergency. N Engl J Med. 2014 Sep 25;371(13):1180-3. doi: 10.1056/NEJMp1409858. Epub 2014 Aug 20. PubMed PMID: 25140855. Krech R, Kieny MP. The 2014 Ebola outbreak: ethical use of unregistered interventions. Bull World Health Organ. 2014 Sep 1;92(9):622. doi: 10.2471/BLT.14.145789. PubMed PMID: 25378748; PubMed Central PMCID: PMC4208580. Boerma T, Eozenou P, Evans D, Evans T, Kieny MP, Wagstaff A. Monitoring progress towards universal health coverage at country and global levels. PLoS Med. 2014 Sep 22;11(9):e1001731. doi: 10.1371/journal.pmed.1001731. eCollection 2014 Sep. PubMed PMID: 25243899; PubMed Central PMCID: PMC4171369. Evans DB, Boerma T, Kieny MP. Monitoring progress towards universal health coverage: recent developments. East Mediterr Health J. 2014 Aug 19;20(8):475-6. PubMed PMID: 25150353.

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2013

Sales M, Kieny MP, Krech R, Etienne C. Human resources for universal health coverage: from evidence to policy and action. Bull World Health Organ. 2013 Nov 1;91(11):798-798A. doi: 10.2471/BLT.13.131110. PubMed PMID: 24347697; PubMed Central PMCID: PMC3853969. Kieny MP, Evans DB. Universal health coverage. East Mediterr Health J. 2013 Apr;19(4):305-6. PubMed PMID: 23882953. Partridge J, Kieny MP. Global production capacity of seasonal influenza vaccine in 2011. Vaccine. 2013 Jan 21;31(5):728-31. doi: 10.1016/j.vaccine.2012.10.111. Epub 2012 Nov 10. PubMed PMID: 23149268.

2012

Mihigo R, Torrealba CV, Coninx K, Nshimirimana D, Kieny MP, Carrasco P, Hedman L, Widdowson MA. 2009 Pandemic influenza A virus subtype H1N1 vaccination in Africa--successes and challenges. J Infect Dis. 2012 Dec 15;206 Suppl 1:S22-8. doi: 10.1093/infdis/jis535. PubMed PMID: 23169967. Ghaffar A, Tran N, Kieny MP, Etienne C. Putting health policy and systems research on the map. Bull World Health Organ. 2012 Nov 1;90(11):797-797A. doi: 10.2471/BLT.12.113118. PubMed PMID: 23226888; PubMed Central PMCID: PMC3506411. Khatib AM, Ali M, von Seidlein L, Kim DR, Hashim R, Reyburn R, Ley B, Thriemer K, Enwere G, Hutubessy R, Aguado MT, Kieny MP, Lopez AL, Wierzba TF, Ali SM, Saleh AA, Mukhopadhyay AK, Clemens J, Jiddawi MS, Deen J. Effectiveness of an oral cholera vaccine in Zanzibar: findings from a mass vaccination campaign and observational cohort study. Lancet Infect Dis. 2012 Nov;12(11):837-44. doi: 10.1016/S1473-3099(12)70196-2. Epub 2012 Sep 4. PubMed PMID: 22954655. Kraushaar D, Kieny MP, Lazarus JV, Bermejo R 3rd, Abimbola S, Prashanth N, Flores W, Ssengooba F, Maceira D. Health Systems Global, the new international society for health systems research. Health Policy Plan. 2012 Oct;27(7):535-40. doi: 10.1093/heapol/czs079. PubMed PMID: 23045410. Tam JS, Barbeschi M, Shapovalova N, Briand S, Memish ZA, Kieny MP. Research agenda for mass gatherings: a call to action. Lancet Infect Dis. 2012 Mar;12(3):231-9. doi: 10.1016/S1473-3099(11)70353-X. Epub 2012 Jan 16. Review. PubMed PMID: 22252148. Hashim R, Khatib AM, Enwere G, Park JK, Reyburn R, Ali M, Chang NY, Kim DR, Ley B, Thriemer K, Lopez AL, Clemens JD, Deen JL, Shin S, Schaetti C, Hutubessy R, Aguado MT, Kieny MP, Sack D, Obaro S, Shaame AJ, Ali SM, Saleh AA, von Seidlein L, Jiddawi MS. Safety of the recombinant cholera toxin B subunit, killed whole-cell (rBS-WC) oral cholera vaccine in pregnancy. PLoS Negl Trop Dis. 2012;6(7):e1743. doi: 10.1371/journal.pntd.0001743. Epub 2012 Jul 24. PubMed PMID: 22848772; PubMed Central PMCID: PMC3404114.

2011

Stittelaar KJ, Veldhuis Kroeze EJ, Rudenko L, Dhere R, Thirapakpoomanunt S, Kieny MP, Osterhaus AD. Efficacy of live attenuated vaccines against 2009 pandemic H1N1 influenza in ferrets. Vaccine.

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2011 Nov 15;29(49):9265-70. doi: 10.1016/j.vaccine.2011.09.049. Epub 2011 Sep 22. PubMed PMID: 21945964. Girard MP, Osmanov S, Assossou OM, Kieny MP. Human immunodeficiency virus (HIV) immunopathogenesis and vaccine development: a review. Vaccine. 2011 Aug 26;29(37):6191-218. doi: 10.1016/j.vaccine.2011.06.085. Epub 2011 Jun 28. Review. PubMed PMID: 21718747. Friede M, Palkonyay L, Alfonso C, Pervikov Y, Torelli G, Wood D, Kieny MP. WHO initiative to increase global and equitable access to influenza vaccine in the event of a pandemic: supporting developing country production capacity through technology transfer. Vaccine. 2011 Jul 1;29 Suppl 1:A2-7. doi: 10.1016/j.vaccine.2011.02.079. Review. PubMed PMID: 21684422. Pourbohloul B, Kieny MP. Complex systems analysis: towards holistic approaches to health systems planning and policy. Bull World Health Organ. 2011 Apr 1;89(4):242. doi: 10.2471/BLT.11.087544. PubMed PMID: 21479083; PubMed Central PMCID: PMC3066532.

2010

Girard MP, Katz J, Pervikov Y, Palkonyay L, Kieny MP. Report of the 6th meeting on the evaluation of pandemic influenza vaccines in clinical trials World Health Organization, Geneva, Switzerland, 17-18 February 2010. Vaccine. 2010 Oct 4;28(42):6811-20. doi: 10.1016/j.vaccine.2010.07.034. Epub 2010 Jul 25. PubMed PMID: 20659520.

2009

Girard MP, Tam JS, Assossou OM, Kieny MP. The 2009 A (H1N1) influenza virus pandemic: A review. Vaccine. 2010 Jul 12;28(31):4895-902. doi: 10.1016/j.vaccine.2010.05.031. Epub 2010 May 27. Review. PubMed PMID: 20553769. Partridge J, Kieny MP; World Health Organization H1N1 influenza vaccine Task Force. Global production of seasonal and pandemic (H1N1) influenza vaccines in 2009-2010 and comparison with previous estimates and global action plan targets. Vaccine. 2010 Jul 5;28(30):4709-12. doi: 10.1016/j.vaccine.2010.04.083. Epub 2010 May 18. PubMed PMID: 20488262. Stephenson I, Hayden F, Osterhaus A, Howard W, Pervikov Y, Palkonyay L, Kieny MP. Report of the fourth meeting on 'Influenza vaccines that induce broad spectrum and long-lasting immune responses', World Health Organization and Wellcome Trust, London, United Kingdom, 9-10 November 2009. Vaccine. 2010 May 21;28(23):3875-82. doi: 10.1016/j.vaccine.2010.03.074. Epub 2010 Apr 14. PubMed PMID: 20398616. Moorthy VS, Kieny MP. Reducing empiricism in malaria vaccine design. Lancet Infect Dis. 2010 Mar;10(3):204-11. doi: 10.1016/S1473-3099(09)70329-9. Review. PubMed PMID: 20185099. Müller T, Dietzschold B, Ertl H, Fooks AR, Freuling C, Fehlner-Gardiner C, Kliemt J, Meslin FX, Franka R, Rupprecht CE, Tordo N, Wanderler AI, Kieny MP. Development of a mouse monoclonal antibody cocktail for post-exposure rabies prophylaxis in humans. PLoS Negl Trop Dis. 2009 Nov 3;3(11):e542. doi: 10.1371/journal.pntd.0000542. Erratum in: PLoS Negl Trop Dis. 2009;3(11): doi: 10.1371/annotation/df98339d-6bdb-40ed-af83-cc38b249264a. Franka, Richard [added]. PubMed PMID: 19888334; PubMed Central PMCID: PMC2765635.

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Kieny MP. WHO supports fair access to influenza A (H1N1) vaccine. Bull World Health Organ. 2009 Sep;87(9):653-4. PubMed PMID: 19784443; PubMed Central PMCID: PMC2739921. Hayden FG, Howard WA, Palkonyay L, Kieny MP. Report of the 5th meeting on the evaluation of pandemic influenza prototype vaccines in clinical trials: World Health Organization, Geneva, Switzerland, 12-13 February 2009. Vaccine. 2009 Jun 24;27(31):4079-89. doi: 10.1016/j.vaccine.2009.04.059. Epub 2009 May 9. PubMed PMID: 19406184. Gryseels B, Zumla A, Troye-Blomberg M, Kieny MP, Quaglio G, Holtel A, Laang H, Romaris M, De Magistris MT, Nuez AN, Olesen OF, Ghalouci R, Lönnroth A. European Union conference on poverty-related diseases research. Lancet Infect Dis. 2009 Jun;9(6):334-7. doi: 10.1016/S1473-3099(09)70129-X. PubMed PMID: 19467472. Moorthy V, Smith PG, Kieny MP. A vaccine against malaria: a substantial step forward. Lancet. 2009 Apr 25;373(9673):1411-2. doi: 10.1016/S0140-6736(09)60802-3. PubMed PMID: 19394521.

2008

Reed ZH, Kieny MP, Engers H, Friede M, Chang S, Longacre S, Malhotra P, Pan W, Long C. Comparison of immunogenicity of five MSP1-based malaria vaccine candidate antigens in rabbits. Vaccine. 2009 Mar 4;27(10):1651-60. doi: 10.1016/j.vaccine.2008.10.093. Epub 2008 Nov 25. PubMed PMID: 19038302. Friede M, Serdobova I, Palkonyay L, Kieny MP. Technology transfer hub for pandemic influenza vaccine. Vaccine. 2009 Jan 29;27(5):631-2. doi: 10.1016/j.vaccine.2008.10.080. Epub 2008 Nov 18. PubMed PMID: 19022316. Noazin S, Modabber F, Khamesipour A, Smith PG, Moulton LH, Nasseri K, Sharifi I, Khalil EA, Bernal ID, Antunes CM, Kieny MP, Tanner M. First generation leishmaniasis vaccines: a review of field efficacy trials. Vaccine. 2008 Dec 9;26(52):6759-67. doi: 10.1016/j.vaccine.2008.09.085. Epub 2008 Oct 23. Review. PubMed PMID: 18950671. Launois P, Tacchini-Cottier F, Kieny MP. Cutaneous leishmaniasis: progress towards a vaccine. Expert Rev Vaccines. 2008 Oct;7(8):1277-87. doi: 10.1586/14760584.7.8.1277. Review. PubMed PMID: 18844599. Girard M, Palkonyay L, Kieny MP. Report of the 4th meeting on the "Evaluation of pandemic influenza prototype vaccines in clinical trials." World Health Organization, Geneva, Switzerland, 14-15 February 2008. Vaccine. 2008 Sep 15;26(39):4975-7. doi: 10.1016/j.vaccine.2008.04.050. Epub 2008 May 9. PubMed PMID: 18514979. Kieny MP, Fukuda K. The pandemic influenza vaccine challenge. Vaccine. 2008 Sep 12;26 Suppl 4:D3-4. PubMed PMID: 19230152. Trotter CL, McVernon J, Ramsay ME, Whitney CG, Mulholland EK, Goldblatt D, Hombach J, Kieny MP; SAGE subgroup. Optimising the use of conjugate vaccines to prevent disease caused by Haemophilus influenzae type b, Neisseria meningitidis and Streptococcus pneumoniae. Vaccine. 2008 Aug 18;26(35):4434-45. doi: 10.1016/j.vaccine.2008.05.073. Epub 2008 Jun 17. Review. PubMed PMID: 18617296.

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Serdobova I, Kieny MP, Freeman I. Venture Capital and Not for Profit Interaction in Medical Innovation: Establishing an Equitable Solution? Business Development and Licensing Journal 2008;(6).

2007

Girard MP, Osterhaus A, Pervikov Y, Palkonyay L, Kieny MP. Report of the third meeting on "influenza vaccines that induce broad spectrum and long-lasting immune responses", World Health Organization, Geneva, Switzerland, 3-4 December 2007. Vaccine. 2008 May 12;26(20):2443-50. doi: 10.1016/j.vaccine.2008.03.006. Epub 2008 Mar 28. PubMed PMID: 18420316. Chaignat CL, Monti V, Soepardi J, Petersen G, Sorensen E, Narain J, Kieny MP. Cholera in disasters: do vaccines prompt new hopes? Expert Rev Vaccines. 2008 May;7(4):431-5. doi: 10.1586/14760584.7.4.431. PubMed PMID: 18444890. Hu J, Chen Z, Gu J, Wan M, Shen Q, Kieny MP, He J, Li Z, Zhang Q, Reed ZH, Zhu Y, Li W, Cao Y, Qu L, Cao Z, Wang Q, Liu H, Pan X, Huang X, Zhang D, Xue X, Pan W. Safety and immunogenicity of a malaria vaccine, Plasmodium falciparum AMA-1/MSP-1 chimeric protein formulated in montanide ISA 720 in healthy adults. PLoS One. 2008 Apr 9;3(4):e1952. doi: 10.1371/journal.pone.0001952. PubMed PMID: 18398475; PubMed Central PMCID: PMC2276862. Thumann C, Schvoerer E, Abraham JD, Bohbot A, Stoll-Keller F, Aubertin AM, Kieny MP. Hepatitis C virus structural proteins do not prevent human dendritic cell maturation. Gastroenterol Clin Biol. 2008 Jan;32(1 Pt. 1):59-68. doi: 10.1016/j.gcb.2007.12.006. Epub 2008 Mar 4. PubMed PMID: 18341978. Paul S, Geist M, Dott K, Snary D, Taylor-Papadimitriou J, Acres B, Silvestre N, Kieny MP, Balloul JM. Specific tumor cell targeting by a recombinant MVA expressing a functional single chain antibody on the surface of intracellular mature virus (IMV) particles. Viral Immunol. 2007 Dec;20(4):664-71. PubMed PMID: 18158739. Kieny MP, LaForce FM. The promise of conjugate vaccines for Africa. Vaccine. 2007 Sep 3;25 Suppl 1:A108-10. Epub 2007 May 21. Review. PubMed PMID: 17548136. Tarantola D, Macklin R, Reed ZH, Kieny MP, Osmanov S, Stobie M, Hankins C. Ethical considerations related to the provision of care and treatment in vaccine trials. Vaccine. 2007 Jun 21;25(26):4863-74. Epub 2007 Mar 30. PubMed PMID: 17466418. Nelson CB, Birmingham M, Costa A, Daviaud J, Perea W, Kieny MP, Tarantola D. Preparedness for infectious threats: public-private partnership to develop an affordable vaccine for an emergent threat: the trivalent Neisseria meningitidis ACW135 polysaccharide vaccine. Am J Public Health. 2007 Apr;97 Suppl 1:S15-22. Epub 2007 Apr 5. PubMed PMID: 17413077; PubMed Central PMCID: PMC1854992. Steele AD, Kieny MP. Satellite Symposium on Challenges to Enteric Vaccines. Journal of Health Population and Nutrition 2007;25(1):118-121.

2006

Girard MP, Reed ZH, Friede M, Kieny MP. A review of human vaccine research and development: malaria. Vaccine. 2007 Feb 19;25(9):1567-80. Epub 2006 Oct 5. Review. PubMed PMID: 17045367.

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Fukuda K, Kieny MP. Different approaches to influenza vaccination. N Engl J Med. 2006 Dec 14;355(24):2586-7. PubMed PMID: 17167142. Kieny MP, Costa A, Hombach J, Carrasco P, Pervikov Y, Salisbury D, Greco M, Gust I, LaForce M, Franco-Paredes C, Santos JI, D'Hondt E, Rimmelzwaan G, Karron R, Fukuda K. A global pandemic influenza vaccine action plan. Vaccine. 2006 Sep 29;24(40-41):6367-70. PubMed PMID: 17240560. Serdobova I, Kieny MP. Assembling a global vaccine development pipeline for infectious diseases in the developing world. Am J Public Health. 2006 Sep;96(9):1554-9. Epub 2006 Jul 27. PubMed PMID: 16873743; PubMed Central PMCID: PMC1551949. Codran A, Royer C, Jaeck D, Bastien-Valle M, Baumert TF, Kieny MP, Pereira CA, Martin JP. Entry of hepatitis C virus pseudotypes into primary human hepatocytes by clathrin-dependent endocytosis. J Gen Virol. 2006 Sep;87(Pt 9):2583-93. PubMed PMID: 16894197. Stephenson I, Gust I, Pervikov Y, Kieny MP. Development of vaccines against influenza H5. Lancet Infect Dis. 2006 Aug;6(8):458-60. PubMed PMID: 16870521. Stöhr K, Kieny MP, Wood D. Influenza pandemic vaccines: how to ensure a low-cost, low-dose option. Nat Rev Microbiol. 2006 Aug;4(8):565-6. PubMed PMID: 16888876. Milstien JB, Kaddar M, Kieny MP. The impact of globalization on vaccine development and availability. Health Aff (Millwood). 2006 Jul-Aug;25(4):1061-9. PubMed PMID: 16835187.

2005

Hampson AW, Osterhaus AD, Pervikov Y, Kieny MP. Report of the second meeting on the development of influenza vaccines that induce broad-spectrum and long-lasting immune responses, World Health Organization, Geneva, Switzerland, 6-7 December 2005. Vaccine. 2006 Jun 5;24(23):4897-4900. PubMed PMID: 16823947. Girard MP, Preziosi MP, Aguado MT, Kieny MP. A review of vaccine research and development: meningococcal disease. Vaccine. 2006 May 29;24(22):4692-700. Epub 2006 Mar 31. Review. PubMed PMID: 16621189. Girard MP, Osmanov SK, Kieny MP. A review of vaccine research and development: the human immunodeficiency virus (HIV). Vaccine. 2006 May 8;24(19):4062-81. Epub 2006 Feb 28. Review. PubMed PMID: 16530298. Girard MP, Steele D, Chaignat CL, Kieny MP. A review of vaccine research and development: human enteric infections. Vaccine. 2006 Apr 5;24(15):2732-50. Epub 2005 Oct 21. Review. PubMed PMID: 16483695. Reed ZH, Friede M, Kieny MP. Malaria vaccine development: progress and challenges. Curr Mol Med. 2006 Mar;6(2):231-45. Review. PubMed PMID: 16515513. Stephenson I, Gust I, Kieny MP, Pervikov Y. Development and evaluation of influenza pandemic vaccines. Lancet Infect Dis. 2006 Feb;6(2):71-2. PubMed PMID: 16439326.

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Kieny MP, Girard MP. Human vaccine research and development: an overview. Vaccine. 2005 Dec 30;23(50):5705-7. Epub 2005 Aug 10. Review. PubMed PMID: 16182415. Girard MP, Cherian T, Pervikov Y, Kieny MP. A review of vaccine research and development: human acute respiratory infections. Vaccine. 2005 Dec 30;23(50):5708-24. Epub 2005 Aug 3. Review. PubMed PMID: 16154667. Girard MP, Fruth U, Kieny MP. A review of vaccine research and development: tuberculosis. Vaccine. 2005 Dec 30;23(50):5725-31. Epub 2005 Aug 8. Review. PubMed PMID: 16153751. Khalil EA, Ayed NB, Musa AM, Ibrahim ME, Mukhtar MM, Zijlstra EE, Elhassan IM, Smith PG, Kieny PM, Ghalib HW, Zicker F, Modabber F, Elhassan AM. Dichotomy of protective cellular immune responses to human visceral leishmaniasis. Clin Exp Immunol. 2005 May;140(2):349-53. PubMed PMID: 15807861; PubMed Central PMCID: PMC1809358. [Note that PubMed displays this record as Kieny PM and not Kieny MP] Kieny MP. Financiamentos Internacional para a Pesquisa e Desenvolvimento de Vacinas e Imunizaçao. In "Vacinas, Soros e Imunizaçoes no Brasil" (eds. PM Buss, JG Temporal, JR Carvalheiro) Editora Fiocruz, Rio de Janeiro 2005;:413-420. Kieny MP, Balloul JM, Bizouarne N. Antitumoral composition based on immunogenic polypeptide with modified cell location. Patent: US7332478, 7 Mar 2005.

2004

Hombach J, Barrett AD, Cardosa MJ, Deubel V, Guzman M, Kurane I, Roehrig JT, Sabchareon A, Kieny MP. Review on flavivirus vaccine development. Proceedings of a meeting jointly organised by the World Health Organization and the Thai Ministry of Public Health, 26-27 April 2004, Bangkok, Thailand. Vaccine. 2005 Apr 15;23(21):2689-95. PubMed PMID: 15841565. Siavoshian S, Abraham JD, Thumann C, Kieny MP, Schuster C. Hepatitis C virus core, NS3, NS5A, NS5B proteins induce apoptosis in mature dendritic cells. J Med Virol. 2005 Mar;75(3):402-11. PubMed PMID: 15648076. Aguado T, Bertherat E, Djingarey M, Kandolo D, Kieny MP, Kondé K, LaForce FM, Nelson CB, Perea W, Préziosi MP. Meningococcal meningitis. Nat Rev Microbiol. 2005 Jan;3(1):10-1. PubMed PMID: 15635779. Kieny MP, Excler JL, Girard M. Research and development of new vaccines against infectious diseases. Am J Public Health. 2004 Nov;94(11):1931-5. Review. PubMed PMID: 15514230; PubMed Central PMCID: PMC1448562. Abraham JD, Himoudi N, Kien F, Berland JL, Codran A, Bartosch B, Baumert T, Paranhos-Baccala G, Schuster C, Inchauspé G, Kieny MP. Comparative immunogenicity analysis of modified vaccinia Ankara vectors expressing native or modified forms of hepatitis C virus E1 and E2 glycoproteins. Vaccine. 2004 Sep 28;22(29-30):3917-28. PubMed PMID: 15364440.

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2003

Pink JR, Kieny MP. 4th meeting on Novel Adjuvants Currently in/close to Human Clinical Testing World Health Organization -- organisation Mondiale de la Santé Fondation Mérieux, Annecy, France, 23-25, June 2003. Vaccine. 2004 Jun 2;22(17-18):2097-102. PubMed PMID: 15212010. Siavoshian S, Abraham JD, Kieny MP, Schuster C. HCV core, NS3, NS5A and NS5B proteins modulate cell proliferation independently from p53 expression in hepatocarcinoma cell lines. Arch Virol. 2004 Feb;149(2):323-36. Epub 2003 Sep 22. PubMed PMID: 14745598. Li J, Li W, Liang S, Cai D, Kieny MP, Jacob L, Linnenbach A, Abramczuk JW, Bender H, Sproesser K, Swoboda R, Somasundaram R, Guerry D, Herlyn D. Recombinant CD63/ME491/neuroglandular/ NKI/C-3 antigen inhibits growth of established tumors in transgenic mice. J Immunol. 2003 Sep 15;171(6):2922-9. PubMed PMID: 12960315. Kieny MP. Malaria vaccines: state of advancement. Med Trop 2003;63:245-246.

2002

Engers H, Kieny MP, Malhotra P, Pink JR. Third meeting on Novel Adjuvants Currently in or Close to Clinical Testing World Health Organization--Organisation Mondiale de la Santé, Fondation Mérieux, Annecy, France, 7-9 January 2002. Vaccine. 2003 Sep 8;21(25-26):3503-24. PubMed PMID: 14518430. Duclos P, Delo A, Aguado T, Bilous J, Birmingham M, Kieny MP, Milstien J, Wood D, Tarantola D. Immunization safety priority project at the World Health Organization. Semin Pediatr Infect Dis. 2003 Jul;14(3):233-9. PubMed PMID: 12913836. Imbert I, Dimitrova M, Kien F, Kieny MP, Schuster C. Hepatitis C virus IRES efficiency is unaffected by the genomic RNA 3'NTR even in the presence of viral structural or non-structural proteins. J Gen Virol. 2003 Jun;84(Pt 6):1549-57. PubMed PMID: 12771425. Dimitrova M, Imbert I, Kieny MP, Schuster C. Protein-protein interactions between hepatitis C virus nonstructural proteins. J Virol. 2003 May;77(9):5401-14. PubMed PMID: 12692242; PubMed Central PMCID: PMC153952. Kien F, Abraham JD, Schuster C, Kieny MP. Analysis of the subcellular localization of hepatitis C virus E2 glycoprotein in live cells using EGFP fusion proteins. J Gen Virol. 2003 Mar;84(Pt 3):561-6. PubMed PMID: 12604806. Kieny MP. [Malaria vaccines: state of advancement]. Med Trop (Mars). 2003;63(3):245-6. French. PubMed PMID: 14579460. Himoudi N, Abraham JD, Fournillier A, Lone YC, Joubert A, Op De Beeck A, Freida D, Lemonnier F, Kieny MP, Inchauspé G. Comparative vaccine studies in HLA-A2.1-transgenic mice reveal a clustered organization of epitopes presented in hepatitis C virus natural infection. J Virol. 2002 Dec;76(24):12735-46. PubMed PMID: 12438599; PubMed Central PMCID: PMC136695. Schuster C, Isel C, Imbert I, Ehresmann C, Marquet R, Kieny MP. Secondary structure of the 3' terminus of hepatitis C virus minus-strand RNA. J Virol. 2002 Aug;76(16):8058-68. PubMed PMID: 12134011; PubMed Central PMCID: PMC155128.

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Paul S, Regulier E, Rooke R, Stoeckel F, Geist M, Homann H, Balloul JM, Villeval D, Poitevin Y, Kieny MP, Acres RB. Tumor gene therapy by MVA-mediated expression of T-cell-stimulating antibodies. Cancer Gene Ther. 2002 May;9(5):470-7. PubMed PMID: 11961670. Zaloudik J, Li W, Jacob L, Kieny MP, Somasundaram R, Acres B, Song H, Zhang T, Li J, Herlyn D. Inhibition of tumor growth by recombinant vaccinia virus expressing GA733/CO17-1A/EpCAM/KSA/KS1-4 antigen in mice. Cancer Gene Ther. 2002 Apr;9(4):382-9. PubMed PMID: 11960289. Papandréou MJ, Barbouche R, Guieu R, Kieny MP, Fenouillet E. The alpha-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step. Mol Pharmacol. 2002 Jan;61(1):186-93. PubMed PMID: 11752220.

2001

Price VL, Kieny MP. Vaccines for parasitic diseases. Curr Drug Targets Infect Disord. 2001 Nov;1(3):315-24. Review. PubMed PMID: 12455404. BenAmmar-Ceccoli S, Humblot S, Crouzier R, Acres B, Kieny MP, Herlyn D, Pasquali JL, Martin T. Recombinant vaccinia viruses expressing immunoglobulin variable regions efficiently and selectively protect mice against tumoral B-cell growth. Cancer Gene Ther. 2001 Oct;8(10):815-26. PubMed PMID: 11687905. Khatissian E, Monceaux V, Cumont MC, Kieny MP, Aubertin AM, Hurtrel B. Persistence of pathogenic challenge virus in macaques protected by simian immunodeficiency virus SIVmacDeltanef. J Virol. 2001 Feb;75(3):1507-15. PubMed PMID: 11152522; PubMed Central PMCID: PMC114055. Perrin P, Jacob Y, Tordo N, Kieny MP. New recombinant vaccines against lyssaviruses. In "Rabies control in Asia" (ed. J Libbley Eurotext) Paris 2001;:156-170.

2000

Scholl SM, Balloul JM, Le Goc G, Bizouarne N, Schatz C, Kieny MP, von Mensdorff-Pouilly S, Vincent-Salomon A, Deneux L, Tartour E, Fridman W, Pouillart P, Acres B. Recombinant vaccinia virus encoding human MUC1 and IL2 as immunotherapy in patients with breast cancer. J Immunother. 2000 Sep-Oct;23(5):570-80. PubMed PMID: 11001550. Barbouche R, Decroly E, Kieny MP, Fenouillet E. An anti-human immunodeficiency virus multiple antigen peptide encompassing the cleavage region of the env precursor interferes with membrane fusion at a post-CD4 binding step. Virology. 2000 Jul 20;273(1):169-77. PubMed PMID: 10891419. Paul S, Snary D, Hoebeke J, Allen D, Balloul JM, Bizouarne N, Dott K, Geist M, Hilgers J, Kieny MP, Burchell J, Taylor-Papadimitriou J, Acres RB. Targeted macrophage cytotoxicity using a nonreplicative live vector expressing a tumor-specific single-chain variable region fragment. Hum Gene Ther. 2000 Jul 1;11(10):1417-28. PubMed PMID: 10910139. Paul S, Bizouarne N, Dott K, Ruet L, Dufour P, Acres RB, Kieny MP. Redirected cellular cytotoxicity by infection of effector cells with a recombinant vaccinia virus encoding a tumor-specific monoclonal antibody. Cancer Gene Ther. 2000 Apr;7(4):615-23. PubMed PMID: 10811480.

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Acres B, Apostolopoulos V, Balloul JM, Wreschner D, Xing PX, Ali-Hadji D, Bizouarne N, Kieny MP, McKenzie IF. MUC1-specific immune responses in human MUC1 transgenic mice immunized with various human MUC1 vaccines. Cancer Immunol Immunother. 2000 Jan;48(10):588-94. PubMed PMID: 10630311. Lafont BA, Rivière Y, Gloeckler L, Beyer C, Hurtrel B, Paule Kieny M, Kirn A, Aubertin AM. Implication of the C-terminal domain of nef protein in the reversion to pathogenicity of attenuated SIVmacBK28-41 in macaques. Virology. 2000 Jan 20;266(2):286-98. PubMed PMID: 10639315. Balloul JM, Bizouarne N, Kieny MP. Pharmaceutical composition for treating papillomavirus tumors and infection. Patent: US7118754, 18 Feb 2000.

1999

Czerkinsky C, Anjuere F, McGhee JR, George-Chandy A, Holmgren J, Kieny MP, Fujiyashi K, Mestecky JF, Pierrefite-Carle V, Rask C, Sun JB. Mucosal immunity and tolerance: relevance to vaccine development. Immunol Rev. 1999 Aug;170:197-222. Review. PubMed PMID: 10566152. Paul S, Bizouarne N, Paul A, Price MR, Hansson GC, Kieny MP, Acres RB. Lack of evidence for an immunosuppressive role for MUC1. Cancer Immunol Immunother. 1999 Apr;48(1):22-8. PubMed PMID: 10235485.

1998

Slos P, Dutot P, Reymund J, Kleinpeter P, Prozzi D, Kieny MP, Delcour J, Mercenier A, Hols P. Production of cholera toxin B subunit in Lactobacillus. FEMS Microbiol Lett. 1998 Dec 1;169(1):29-36. PubMed PMID: 9851032. Barbouche R, Fenouillet E, Papandréou MJ, Kiény MP, Sabatier JM. Properties of HIV envelope expressed in the presence of SPC3, an Env-derived peptide drug under phase II clinical trials. J Pept Res. 1998 Oct;52(4):283-8. PubMed PMID: 9832306. [Note that PubMed displays this record as Kiény MP and not Kieny MP] Chambon P, Kieny MP, Lathe R, Hareuveni M. Pharmaceutical composition for the treatment or prevention of a malignant tumor. Patent: US6328956, 17 Aug 1998. Kieny MP, Balloul JM, Bizouarne N. Antitumoral composition based on immunogenic polypeptide with modified cell location. Patent: US6884786, 17 Jul 1998.

1997

Coëffier E, Excler JL, Kieny MP, Meignier B, Moste C, Tartaglia J, Pialoux G, Salmon-Céron D, Leclerc C. Restricted specificity of anti-V3 antibodies induced in humans by HIV candidate vaccines. AIDS Res Hum Retroviruses. 1997 Nov 20;13(17):1471-85. PubMed PMID: 9390746. Dunn CS, Hurtrel B, Beyer C, Gloeckler L, Ledger TN, Moog C, Kieny MP, Mehtali M, Schmitt D, Gut JP, Kirn A, Aubertin AM. Protection of SIVmac-infected macaque monkeys against superinfection by a

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simian immunodeficiency virus expressing envelope glycoproteins of HIV type 1. AIDS Res Hum Retroviruses. 1997 Jul 20;13(11):913-22. PubMed PMID: 9223407. Malvoisin E, Kiény MP, Wild F. Self-association of truncated forms of HIV-1 gp120. Virus Res. 1997 Jun;49(2):163-72. PubMed PMID: 9213391. [Note that PubMed displays this record as Kiény MP and not Kieny MP] Rose KA, Stapleton G, Dott K, Kieny MP, Best R, Schwarz M, Russell DW, Björkhem I, Seckl J, Lathe R. Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone. Proc Natl Acad Sci U S A. 1997 May 13;94(10):4925-30. PubMed PMID: 9144166; PubMed Central PMCID: PMC24607. Kieny MP. Etude des virus isolés chez sept volontaires infectés par le VIH-1 malgré un protocole de vaccination expérimentale. Transcriptase 1997;(61):30-31. Acres RB, Scholl S, Pouillart P, Bizouane N, Balloul JM, Kieny MP, et al. A phase 1 clinical trial with a recombinant vaccinia virus expressing MUC1 and IL2. Immunol Lett 1997;56(1):38. Bizouarne N, Acres B, Balloul JM, Kieny MP. Breast cancer immunotherapy: Preclinical study of a recombinant vaccinia virus vector expressing MUC1 and IL2. Immunol Lett 1997;56(1):339. Cuillerot JM, Michou AI, Kieny MP, Oberling F, Ferrand P, Bohbot A, et al. Adenovirus mediated gene transfer in dendritic cells. Immunol Lett 1997;56(1):162. Lathe R, Kieny MP, Meneguzzi G. Expression of a tumor-specific antigen by a recombinant vector virus and use thereof in preventive or curative treatment of the corresponding tumor. Patent: US6007806, 12 Dec 1997.

1996

Perraut R, Chouteau P, Moog C, Bonnemains B, Kieny MP. Immunogenicity of HIV-1LAI gp160 and env peptides in squirrel monkey Saimiri sciureus using alumine and experimental adjuvants. Clin Exp Immunol. 1996 Dec;106(3):434-41. PubMed PMID: 8973609; PubMed Central PMCID: PMC2200625. Fleury B, Janvier G, Pialoux G, Buseyne F, Robertson MN, Tartaglia J, Paoletti E, Kieny MP, Excler JL, Rivière Y. Memory cytotoxic T lymphocyte responses in human immunodeficiency virus type 1 (HIV-1)-negative volunteers immunized with a recombinant canarypox expressing gp 160 of HIV-1 and boosted with a recombinant gp160. J Infect Dis. 1996 Oct;174(4):734-8. PubMed PMID: 8843210. Dunn CS, Beyer C, Kieny MP, Gloeckler L, Schmitt D, Gut JP, Kirn A, Aubertin AM. High viral load and CD4 lymphopenia in rhesus and cynomolgus macaques infected by a chimeric primate lentivirus constructed using the env, rev, tat, and vpu genes from HIV-1 Lai. Virology. 1996 Sep 15;223(2):351-61. PubMed PMID: 8806570. McCutchan FE, Artenstein AW, Sanders-Buell E, Salminen MO, Carr JK, Mascola JR, Yu XF, Nelson KE, Khamboonruang C, Schmitt D, Kieny MP, McNeil JG, Burke DS. Diversity of the envelope glycoprotein among human immunodeficiency virus type 1 isolates of clade E from Asia and Africa. J Virol. 1996 Jun;70(6):3331-8. PubMed PMID: 8648662; PubMed Central PMCID: PMC190203.

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Kaplan C, Morel-Kopp MC, Kieny MP, Kolbe H, Salmon P, Sicard D, Pialoux G, Meignier B, Excler JL, Plotkin S. Antiplatelet antibodies during the course of HIV-preventive vaccine trial. AIDS. 1996 Apr;10(4):447-9. PubMed PMID: 8728055. Herlyn D, Somasundaram R, Zaloudik J, Li W, Jacob L, Harris D, Kieny MP, Ricciardi R, Gonczol E, Sears H, et al. Cloned antigens and antiidiotypes. Hybridoma. 1995 Apr;14(2):159-66. PubMed PMID: 7590774. Bizouarne N, Balloul JM, Schatz C, Acres B, Kieny MP. Immunotherapy of breast cancer using a recombinant vaccinia virus expressing the human MUC1 and IL2 genes. In "Breast cancer. Advances in biology and therapeutics" (eds. F Calvo, M Crépin, H. Magdalenat) 1996;:303-322.

1995

Salmon-Céron D, Excler JL, Sicard D, Blanche P, Finkielstzjen L, Gluckman JC, Autran B, Matthews TJ, Meignier B, Kieny MP, et al. Safety and immunogenicity of a recombinant HIV type 1 glycoprotein 160 boosted by a V3 synthetic peptide in HIV-negative volunteers. AIDS Res Hum Retroviruses. 1995 Dec;11(12):1479-86. PubMed PMID: 8679292. Girard M, Meignier B, Barré-Sinoussi F, Kieny MP, Matthews T, Muchmore E, Nara PL, Wei Q, Rimsky L, Weinhold K, et al. Vaccine-induced protection of chimpanzees against infection by a heterologous human immunodeficiency virus type 1. J Virol. 1995 Oct;69(10):6239-48. PubMed PMID: 7666524; PubMed Central PMCID: PMC189521. Boudet F, Keller H, Kieny MP, Thèze J. Single peptide and anti-idiotype based immunizations can broaden the antibody response against the variable V3 domain of HIV-1 in mice. Mol Immunol. 1995 May;32(7):449-57. PubMed PMID: 7783749. Herlyn D, Somasundaram R, Zaloudik J, Li W, Jacob L, Harris D, Kieny MP, Ricciardi R, Gonczol E, Sears H, et al. Cloned antigens and antiidiotypes. Hybridoma. 1995 Apr;14(2):159-66. PubMed PMID: 7590774. Abimiku AG, Franchini G, Tartaglia J, Aldrich K, Myagkikh M, Markham PD, Chong P, Klein M, Kieny MP, Paoletti E, et al. HIV-1 recombinant poxvirus vaccine induces cross-protection against HIV-2 challenge in rhesus macaques. Nat Med. 1995 Apr;1(4):321-9. PubMed PMID: 7585061. Pialoux G, Excler JL, Rivière Y, Gonzalez-Canali G, Feuillie V, Coulaud P, Gluckman JC, Matthews TJ, Meignier B, Kieny MP, et al. A prime-boost approach to HIV preventive vaccine using a recombinant canarypox virus expressing glycoprotein 160 (MN) followed by a recombinant glycoprotein 160 (MN/LAI). The AGIS Group, and l'Agence Nationale de Recherche sur le SIDA. AIDS Res Hum Retroviruses. 1995 Mar;11(3):373-81. Erratum in: AIDS Res Hum Retroviruses 1995 Jul;11(7):875. PubMed PMID: 7598771. Vogt G, le Grand R, Vaslin B, Boussin F, Auboyer MH, Rivière Y, Putkonen P, Sonigo P, Kieny MP, Girard M, et al. Heterologous HIV-2 challenge of rhesus monkeys immunized with recombinant vaccinia viruses and purified recombinant HIV-2 proteins. Vaccine. 1995 Feb;13(2):202-8. PubMed PMID: 7625117. Dunn CS, Kieny MP, Beyer C, Gloeckler L, Schmitt D, Gut JP, et al. High viral loads and CD4 lymphopaenia resulting from infection of rhesus monkeys with a chimaeric primate lentivirus. In

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"Dixième Colloque des Cent Gardes" (eds. M Girard, L Valette) Fondation Marcel Mérieux Publications 1995;:207-210. Kieny MP. Immunogenic compositions comprising soluble, non-cleavable, chimeric HIV-1 gp160-variants. Patent: US6284248, 7 Jun 1995. Kieny MP, Rautmann G, Lecocq JP, Wain Hobson S, Girard M, Montagnier L, et al. Non-cleavable GP160 glycoproteins of HIV. Patent: US5672689, 17 May 1995. Kieny MP, Rautmann G, Lecocq JP, Wain Hobson S, Girard M, Montagnier L, et al. Viral vector coding for a glycoprotein of the virus responsible for AIDS. Patent: US5795577, 7 Jun 1995.

1994

Moulard M, Achstetter T, Kieny MP, Montagnier L, Bahraoui E. Kex2p: a model for cellular endoprotease processing human immunodeficiency virus type 1 envelope glycoprotein precursor. Eur J Biochem. 1994 Oct 15;225(2):565-72. PubMed PMID: 7957171. Slos P, Speck D, Accart N, Kolbe HV, Schubnel D, Bouchon B, Bischoff R, Kieny MP. Recombinant cholera toxin B subunit in Escherichia coli: high-level secretion, purification, and characterization. Protein Expr Purif. 1994 Oct;5(5):518-26. PubMed PMID: 7827509. Robert-Guroff M, Louie A, Myagkikh M, Michaels F, Kieny MP, White-Scharf ME, Potts B, Grogg D, Reitz MS Jr. Alteration of V3 loop context within the envelope of human immunodeficiency virus type 1 enhances neutralization. J Virol. 1994 Jun;68(6):3459-66. PubMed PMID: 7514675; PubMed Central PMCID: PMC236848. Herlyn D, Harris D, Zaloudik J, Sperlagh M, Maruyama H, Jacob L, Kieny MP, Scheck S, Somasundaram R, Hart E, et al. Immunomodulatory activity of monoclonal anti-idiotypic antibody to anti-colorectal carcinoma antibody CO17-1A in animals and patients. J Immunother Emphasis Tumor Immunol. 1994 May;15(4):303-11. PubMed PMID: 8061902. Robertson MN, Buseyne F, Kieny MP, Rivière Y. Strain specificity of cell-mediated cytotoxic responses specific for the human immunodeficiency virus type 1 (HIV-1) envelope protein in seropositive donors: HIV-1Lai is more commonly recognized than HIV-1MN. J Infect Dis. 1994 Feb;169(2):274-80. PubMed PMID: 7906289. Herlyn D, Somasundaram R, Zaloudik J, Jacob L, Harris D, Kieny MP, Sears H, Mastrangelo M. Anti-idiotype and recombinant antigen in immunotherapy of colorectal cancer. Cell Biophys. 1994;24-25:143-53. Review. PubMed PMID: 7736518. Acres B, Dott K, Stefani L, Kieny MP. Directed cytokine expression in tumour cells in vivo using recombinant vaccinia virus. Ther Immunol. 1994 Jan;1(1):17-23. PubMed PMID: 7584475. Balloul JM, Acres RB, Geist M, Dott K, Stefani L, Schmitt D, Drillien R, Spehner D, McKenzie I, Xing PX, et al. Recombinant MUC 1 vaccinia virus: a potential vector for immunotherapy of breast cancer. Cell Mol Biol (Noisy-le-grand). 1994;40 Suppl 1:49-59. PubMed PMID: 7950862. Pastoret PP, Brochier B, Boulanger D, Chappuis G, Kieny MP. Rabies recombinant vaccines: development and field application. In "Modern Vaccinology" (ed. E Kurstak) Plenum Medical, New York 1994;:303-318.

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Balayan M, Bhamarapravati N, Burke D, Chandler DK, Desrosiers R, Schild G, et al. Feasibility of developing live attenuated HIV vaccines - Conclusions and Recommendations. AIDS Res Hum Retroviruses 1994;(10):221-222. Lathe R, Kieny MP, Drillien R, Lecocq JP. Vaccine against rabies and process for preparation thereof. Patent: US6024953, 21 Apr 1994.

1993

Murphy E, Korber B, Georges-Courbot MC, You B, Pinter A, Cook D, Kieny MP, Georges A, Mathiot C, Barré-Sinoussi F, et al. Diversity of V3 region sequences of human immunodeficiency viruses type 1 from the central African Republic. AIDS Res Hum Retroviruses. 1993 Oct;9(10):997-1006. PubMed PMID: 8280481. Gotch F, McAdam SN, Allsopp CE, Gallimore A, Elvin J, Kieny MP, Hill AV, McMichael AJ, Whittle HC. Cytotoxic T cells in HIV2 seropositive Gambians. Identification of a virus-specific MHC-restricted peptide epitope. J Immunol. 1993 Sep 15;151(6):3361-9. PubMed PMID: 7690804. Taupin JL, Acres B, Dott K, Schmitt D, Kieny MP, Gualde N, Moreau JF. Immunogenicity of HILDA/LIF either in a soluble or in a membrane anchored form expressed in vivo by recombinant vaccinia viruses. Scand J Immunol. 1993 Sep;38(3):293-301. PubMed PMID: 8356405. Laurent-Crawford AG, Krust B, Rivière Y, Desgranges C, Muller S, Kieny MP, Dauguet C, Hovanessian AG. Membrane expression of HIV envelope glycoproteins triggers apoptosis in CD4 cells. AIDS Res Hum Retroviruses. 1993 Aug;9(8):761-73. PubMed PMID: 8105835. Acres RB, Hareuveni M, Balloul JM, Kieny MP. Vaccinia virus MUC1 immunization of mice: immune response and protection against the growth of murine tumors bearing the MUC1 antigen. J Immunother Emphasis Tumor Immunol. 1993 Aug;14(2):136-43. PubMed PMID: 8280702. Fenouillet E, Jones I, Powell B, Schmitt D, Kieny MP, Gluckman JC. Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain. J Virol. 1993 Jan;67(1):150-60. PubMed PMID: 8093218; PubMed Central PMCID: PMC237347. Kieny MP, Aubertin AM, Benavente A, Schmitt D, Dott K, Beyer C, et al. Protection of monkeys against SIV infection with live attenuated viruses. In "Huitième Colloque des Cent Gardes" (eds. M Girard, L. Valette) Fondation Marcel Mérieux Publications 1993;:211-218. Kieny MP. Vaccin anti-VIH : passage à la vitesse supérieure. Transcriptase 1993;(17):4-5.

1992

Mehtali M, Munschy M, Ali-Hadji D, Kieny MP. A novel transgenic mouse model for the in vivo evaluation of anti-human immunodeficiency virus type 1 drugs. AIDS Res Hum Retroviruses. 1992 Dec;8(12):1959-65. PubMed PMID: 1493046. Lamhamedi-Cherradi S, Culmann-Penciolelli B, Guy B, Kiény MP, Dreyfus F, Saimot AG, Sereni D, Sicard D, Lévy JP, Gomard E. Qualitative and quantitative analysis of human cytotoxic T-lymphocyte

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responses to HIV-1 proteins. AIDS. 1992 Nov;6(11):1249-58. PubMed PMID: 1472331. [Note that PubMed displays this record as Kiény MP and not Kieny MP] Kieny MP. [AIDS: vaccination against HIV]. Pathol Biol (Paris). 1992 Nov;39(9):876. French. PubMed PMID: 1538917. Fultz PN, Nara P, Barre-Sinoussi F, Chaput A, Greenberg ML, Muchmore E, Kieny MP, Girard M. Vaccine protection of chimpanzees against challenge with HIV-1-infected peripheral blood mononuclear cells. Science. 1992 Jun 19;256(5064):1687-90. PubMed PMID: 1609280. Benichou S, Legrand R, Nakagawa N, Faure T, Traincard F, Vogt G, Dormont D, Tiollais P, Kieny MP, Madaule P. Identification of a neutralizing domain in the external envelope glycoprotein of simian immunodeficiency virus. AIDS Res Hum Retroviruses. 1992 Jun;8(6):1165-70. PubMed PMID: 1380263. Girard M, Kieny MP, Barré-Sinoussi F, Nara P, Muchmore E, Fultz P. [Experimental vaccination against HIV-1 protects the chimpanzee against challenge with injections of infected lymphocytes]. Bull Acad Natl Med. 1992 Jun;176(6):921-34; discussion 935. French. PubMed PMID: 1464038. Venet A, Bourgault I, Aubertin AM, Kiény MP, Levy JP. Cytotoxic T lymphocyte response against multiple simian immunodeficiency virusA (SIV) proteins in SIV-infected macaques. J Immunol. 1992 May 1;148(9):2899-908. PubMed PMID: 1349322. [Note that PubMed displays this record as Kiény MP and not Kieny MP] Michel F, Hoffenbach A, Froussard P, Langlade-Demoyen P, Kaczorek M, Kieny MP, Plata F. HIV-1 env, nef, and gag-specific T-cell immunity in mice: conserved epitopes in nef p27 and gag p25 proteins. AIDS Res Hum Retroviruses. 1992 Apr;8(4):469-78. PubMed PMID: 1376136. Wiktor TJ, MacFarlan RI, Reagan KJ, Dietzschold B, Curtis PJ, Wunner WH, Kieny MP, Lathe R, Lecocq JP, Mackett M, et al. Protection from rabies by a vaccinia virus recombinant containing the rabies virus glycoprotein gene. 1984. Biotechnology. 1992;24:508-12. PubMed PMID: 1422063. Hadida F, Parrot A, Kieny MP, Sadat-Sowti B, Mayaud C, Debre P, Autran B. Carboxyl-terminal and central regions of human immunodeficiency virus-1 NEF recognized by cytotoxic T lymphocytes from lymphoid organs. An in vitro limiting dilution analysis. J Clin Invest. 1992 Jan;89(1):53-60. PubMed PMID: 1370302; PubMed Central PMCID: PMC442818. Guy B, Acres RB, Rivière Y, Kieny MP. The HIV Nef protein: facts and hypotheses. Res Virol. 1992 Jan-Feb;143(1):34-7. Review. PubMed PMID: 1565852. Rupprecht CE, Kieny MP. Development of vaccinia-rabies glycoprotein recombinant virus vaccine. In "Rabies" (eds. JB. Campbell, KM Charlton) Kluwer Academic Publishers 1992;:224-264. Kieny MP. Novel antigen presentation systems: a review. In "Sixième Colloque des Cent Gardes" (eds. M Girard, L. Valette) Fondation Marcel Mérieux Publications 1992;:101-103. Voss G, Nick S, Kirchhoff F, Jentsch KD, Stahl-Hennig C, Kieny MP, et al. Detection of gag-specific cytotoxic T lymphocytes in HIV-2ben-infected macaques. Cytotoxic T cells in HIV and other retroviral infections (eds. P Racz, NL Letvin, JC Gluckman) Karger, Basel 1992;:103-113.

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Sondermeyer P, Balloul JM, Pierce R, Grzych JM, Kieny MP, Loison G, et al. Protein recognized by antibodies raised against native P28 of schistosoma mansoni. Patent: US5597570, 21 Oct 1992. Kieny MP. Expression cassettes encoding soluble, non-cleavable, chimeric HIV-1 GP160 variants, their methods of construction, and methods for the production of GP160 variants. Patent: US6261799, 31 Dec 1992.

1991

Winter N, Lagranderie M, Rauzier J, Timm J, Leclerc C, Guy B, Kieny MP, Gheorghiu M, Gicquel B. Expression of heterologous genes in Mycobacterium bovis BCG: induction of a cellular response against HIV-1 Nef protein. Gene. 1991 Dec 20;109(1):47-54. PubMed PMID: 1756981. Brochier B, Kieny MP, Costy F, Coppens P, Bauduin B, Lecocq JP, Languet B, Chappuis G, Desmettre P, Afiademanyo K, et al. Large-scale eradication of rabies using recombinant vaccinia-rabies vaccine. Nature. 1991 Dec 19-26;354(6354):520-2. PubMed PMID: 1758494. Van Bressem MF, De Meurichy J, Chappuis G, Spehner D, Kieny MP, Pastoret PP. Attempt to vaccinate orally harbour seals against phocid distemper. Vet Rec. 1991 Oct 19;129(16):362. PubMed PMID: 1759340. Neurath AR, Jiang S, Strick N, Kolbe H, Kieny MP, Muchmore E, Girard M. Antibody responses of chimpanzees immunized with synthetic peptides corresponding to full-length V3 hypervariable loops of HIV-1 envelope glycoproteins. AIDS Res Hum Retroviruses. 1991 Oct;7(10):813-23. PubMed PMID: 1720628. Neurath AR, Strick N, Kolbe H, Kieny MP, Girard M, Jiang S. Confronting the hypervariability of an immunodominant epitope eliciting virus neutralizing antibodies from the envelope glycoprotein of the human immunodeficiency virus type 1 (HIV-1)--II. Synthetic peptides linked to HIV-1 carrier proteins gag and nef. Mol Immunol. 1991 Sep;28(9):965-73. PubMed PMID: 1717841. Hareuveni M, Wreschner DH, Kieny MP, Dott K, Gautier C, Tomasetto C, Keydar I, Chambon P, Lathe R. Vaccinia recombinants expressing secreted and transmembrane forms of breast cancer-associated epithelial tumour antigen (ETA). Vaccine. 1991 Sep;9(9):618-26. PubMed PMID: 1950095. Dezutter-Dambuyant C, Schmitt DA, Dusserre N, Hanau D, Kolbe HV, Kieny MP, Cazenave JP, Schmitt D, Pasquali JL, Olivier R, et al. Interaction of human epidermal Langerhans cells with HIV-1 viral envelope proteins (gp 120 and gp 160s) involves a receptor-mediated endocytosis independent of the CD4 T4A epitope. J Dermatol. 1991 Jul;18(7):377-92. PubMed PMID: 1724250. Culmann B, Gomard E, Kiény MP, Guy B, Dreyfus F, Saimot AG, Sereni D, Sicard D, Lévy JP. Six epitopes reacting with human cytotoxic CD8+ T cells in the central region of the HIV-1 NEF protein. J Immunol. 1991 Mar 1;146(5):1560-5. PubMed PMID: 1704397. [Note that PubMed displays this record as Kiény MP and not Kieny MP] Guy B, Geist M, Dott K, Spehner D, Kieny MP, Lecocq JP. A specific inhibitor of cysteine proteases impairs a Vif-dependent modification of human immunodeficiency virus type 1 Env protein. J Virol. 1991 Mar;65(3):1325-31. PubMed PMID: 1995946; PubMed Central PMCID: PMC239908. Dezutter-Dambuyant C, Schmitt DA, Dusserre N, Hanau D, Kolbe HV, Kieny MP, Gazzolo L, Macé K, Pasquali JL, Olivier R. Trypsin-resistant gp120 receptors are upregulated on short-term cultured

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human epidermal Langerhans cells. Res Virol. 1991 Mar-Jun;142(2-3):129-38. PubMed PMID: 1896637. Meneguzzi G, Cerni C, Kieny MP, Lathe R. Immunization against human papillomavirus type 16 tumor cells with recombinant vaccinia viruses expressing E6 and E7. Virology. 1991 Mar;181(1):62-9. PubMed PMID: 1847269. Girard M, Kieny MP, Pinter A, Barre-Sinoussi F, Nara P, Kolbe H, Kusumi K, Chaput A, Reinhart T, Muchmore E, et al. Immunization of chimpanzees confers protection against challenge with human immunodeficiency virus. Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):542-6. PubMed PMID: 1988952; PubMed Central PMCID: PMC50847. Nakagawa N, Nakagawa T, Acres B, Yasukawa K, Kieny MP. In vivo delivery of interleukin-6 using vaccinia virus: effects on T lymphocytes in nude mice. Eur Cytokine Netw. 1991 Jan-Feb;2(1):11-6. PubMed PMID: 1873489. Kieny MP. Vaccination against rabies. In "Vaccine and Immunology" (ed. SJ CRYZ, Jr.) Pergamon Press 1991;(19):246-255. Kieny MP. Approaches to vaccination against primate immunodeficiency viruses infection. In "Cinquième Colloque des Cent Gardes" (eds. M Girard, L Valette) Fondation Marcel Mérieux Publications 1991;:171-175. Mehtali M, Acres B, Kieny MP. Transgenic mice expressing HIV genes for in vivo evaluation of anti-HIV drugs. In "Viral Quantitation in HIV Infection" (ed. JM Andrieu) John Libbey Eurotext, Paris 1991;:97-111. Kieny MP. SIDA : La vaccination contre le virus. Path Biol 1991;39:876.

1990

Hareuveni M, Gautier C, Kieny MP, Wreschner D, Chambon P, Lathe R. Vaccination against tumor cells expressing breast cancer epithelial tumor antigen. Proc Natl Acad Sci U S A. 1990 Dec;87(23):9498-502. PubMed PMID: 2251291; PubMed Central PMCID: PMC55194. Skern T, Bischoff R, Jallat S, Dott K, Ali-Hadji D, Clesse D, Kieny MP, Courtney M. Sulphation of hirudin in BHK cells. FEBS Lett. 1990 Nov 26;275(1-2):36-8. PubMed PMID: 2261997. Laurent AG, Hovanessian AG, Rivière Y, Krust B, Regnault A, Montagnier L, Findeli A, Kieny MP, Guy B. Production of a non-functional nef protein in human immunodeficiency virus type 1-infected CEM cells. J Gen Virol. 1990 Oct;71 ( Pt 10):2273-81. PubMed PMID: 1977871. Nixon DF, Huet S, Rothbard J, Kieny MP, Delchambre M, Thiriart C, Rizza CR, Gotch FM, McMichael AJ. An HIV-1 and HIV-2 cross-reactive cytotoxic T-cell epitope. AIDS. 1990 Sep;4(9):841-5. PubMed PMID: 1701304. Pasquali JL, Kieny MP, Kolbe H, Christmann D, Knapp AM. Immunogenicity and epitope mapping of a recombinant soluble gp160 of the human immunodeficiency virus type 1 envelope glycoprotein. AIDS Res Hum Retroviruses. 1990 Sep;6(9):1107-13. PubMed PMID: 1702300.

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Trottein F, Kieny MP, Verwaerde C, Torpier G, Pierce RJ, Balloul JM, Schmitt D, Lecocq JP, Capron A. Molecular cloning and tissue distribution of a 26-kilodalton Schistosoma mansoni glutathione S-transferase. Mol Biochem Parasitol. 1990 Jun;41(1):35-44. PubMed PMID: 2385266. Meneguzzi G, Kieny MP, Lecocq JP, Chambon P, Cuzin F, Lathe R. Vaccinia recombinants expressing early bovine papilloma virus (BPV1) proteins: retardation of BPV1 tumour development. Vaccine. 1990 Jun;8(3):199-204. PubMed PMID: 2163573. Desmettre P, Languet B, Chappuis G, Brochier B, Thomas I, Lecocq JP, Kieny MP, Blancou J, Aubert M, Artois M, et al. Use of vaccinia rabies recombinant for oral vaccination of wildlife. Vet Microbiol. 1990 Jun;23(1-4):227-36. Review. PubMed PMID: 2205969. Guy B, Rivière Y, Dott K, Regnault A, Kieny MP. Mutational analysis of the HIV nef protein. Virology. 1990 Jun;176(2):413-25. PubMed PMID: 2111956. Schmitt D, Dezutter-Dambuyant C, Hanau D, Kolbe HV, Kieny MP, Cazenave JP, Thivolet J. In vitro binding and internalization of HIV envelope glycoproteins by human epidermal Langerhans cells does not require the CD4-gp120-binding site. Res Virol. 1990 Mar-Apr;141(2):209-15. PubMed PMID: 1693220. Kieny MP, Gautier C, Tomasetto C, Kuhn I, Hareuveni M, Clertant P, Lathe R. Vaccination against polyoma virus (PyV) tumors using vaccinia-PyV recombinants: a major tumor-specific transplantation antigen (TSTA) epitope resides within the C-terminal segment of middle-T protein. Int J Cancer. 1990 Jan 15;45(1):185-9. PubMed PMID: 1688831. McChesney M, Tanneau F, Regnault A, Sansonetti P, Montagnier L, Kieny MP, Rivière Y. Detection of primary cytotoxic T lymphocytes specific for the envelope glycoprotein of HIV-1 by deletion of the env amino-terminal signal sequence. Eur J Immunol. 1990 Jan;20(1):215-20. PubMed PMID: 2106442. Guy B, Acres B, Kieny MP, Lecocq JP. DNA binding factors that bind to the negative regulatory element of the human immunodeficiency virus-1: regulation by nef. J Acquir Immune Defic Syndr. 1990;3(8):797-809. PubMed PMID: 2195154. Kieny MP. Structure and regulation of the human AIDS virus. J Acquir Immune Defic Syndr. 1990;3(4):395-402. PubMed PMID: 2179526. Thomas I, Brochier B, Languet B, Blancou J, Peharpre D, Kieny MP, Desmettre P, Chappuis G, Pastoret PP. Primary multiplication site of the vaccinia-rabies glycoprotein recombinant virus administered to foxes by the oral route. J Gen Virol. 1990 Jan;71 ( Pt 1):37-42. PubMed PMID: 2406370. Girard M, Fultz P, Kieny MP, Yagello M, Deslandres A, Muchmore E, et al. Immune responses of chimpanzees to live recombinant, inactivated, subunit and synthetic prototype HIV vaccines. In "4ème Colloque des Cent Gardes" (eds. M Girard, L Valette) Fondation Marcel Mérieux Publications 1990;:265-269. Lecocq JP, Kieny MP, Capron A, Pastoret PP. Recent progress in genetically engineered vaccines against viruses and parasites. In "Biotec 3, Therapeutics, Diagnostics, Cell Cultures, and Product Isolation" (eds. CP Hollenbergm, H Sahm) Gustav Fischer Verlag, Stuttgart, New York 1990;3:21-26.

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Lecocq JP, Courtney M, Degryse E, Jallat S, Kieny MP, Meulien P, et al. New Engineered Proteins for Use in Therapy and Vaccine Design. In "Protein Design and the Development of New Therapeutics and Vaccines" (eds. Hook, Poste) Plenum Publishing Corporation, New York 1990;:283-295. Kieny MP. Structure et Pathogénèse du Virus de l'Immunodéficience Humaine. Le Nouveau Biologiste 1990.

1989

Culmann B, Gomard E, Kiény MP, Guy B, Dreyfus F, Saimot AG, Sereni D, Lévy JP. An antigenic peptide of the HIV-1 NEF protein recognized by cytotoxic T lymphocytes of seropositive individuals in association with different HLA-B molecules. Eur J Immunol. 1989 Dec;19(12):2383-6. PubMed PMID: 2481593. [Note that PubMed displays this record as Kiény MP and not Kieny MP] Meneguzzi G, Lathe R, Kieny MP, Vogt N. The E2 trans-activating protein of bovine papillomavirus type 1 (BPV1) is serine-phosphorylated in vivo. Oncogene. 1989 Nov;4(11):1285-90. PubMed PMID: 2554235. Brochier B, Blancou J, Thomas I, Languet B, Artois M, Kieny MP, Lecocq JP, Costy F, Desmettre P, Chappuis G, et al. Use of recombinant vaccinia-rabies glycoprotein virus for oral vaccination of wildlife against rabies: innocuity to several non-target bait consuming species. J Wildl Dis. 1989 Oct;25(4):540-7. PubMed PMID: 2681844. Kolbe HV, Jaeger F, Lepage P, Roitsch C, Lacaud G, Kieny MP, Sabatie J, Brown SW, Lecocq JP, Girard M. Isolation of recombinant partial gag gene product p18 (HIV-1Bru) from Escherichia coli. J Chromatogr. 1989 Aug 4;476:99-112. PubMed PMID: 2674178. Brochier BM, Blancou J, Aubert MF, Kieny MP, Desmettre P, Pastoret PP. Interaction between rabies infection and oral administration of vaccinia-rabies recombinant virus to foxes (Vulpes vulpes). J Gen Virol. 1989 Jun;70 ( Pt 6):1601-4. PubMed PMID: 2732723. Riviere Y, Tanneau-Salvadori F, Regnault A, Lopez O, Sansonetti P, Guy B, Kieny MP, Fournel JJ, Montagnier L. Human immunodeficiency virus-specific cytotoxic responses of seropositive individuals: distinct types of effector cells mediate killing of targets expressing gag and env proteins. J Virol. 1989 May;63(5):2270-7. PubMed PMID: 2522999; PubMed Central PMCID: PMC250645. Rautmann G, Kieny MP, Brandely R, Dott K, Girard M, Montagnier L, Lecocq JP. HIV-1 core proteins expressed from recombinant vaccinia viruses. AIDS Res Hum Retroviruses. 1989 Apr;5(2):147-57. PubMed PMID: 2713165. Van Eendenburg JP, Yagello M, Girard M, Kieny MP, Lecocq JP, Muchmore E, Fultz PN, Riviere Y, Montagnier L, Gluckman JC. Cell-mediated immune proliferative responses to HIV-1 of chimpanzees vaccinated with different vaccinia recombinant viruses. AIDS Res Hum Retroviruses. 1989 Feb;5(1):41-50. PubMed PMID: 2470398. Blancou J, Artois M, Brochier B, Thomas I, Pastoret PP, Desmettre P, Languet B, Kiény MP. [Safety and efficacy of an antirabies vaccine consisting of recombinant vaccinia-rabies virus administered orally to the fox, dog and cat]. Ann Rech Vet. 1989;20(2):195-204. French. PubMed PMID: 2751231. [Note that PubMed displays this record as Kiény MP and not Kieny MP]

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Schmitt D, Dezutter-Dambuyant C, Hanau D, Schmitt DA, Kolbe HV, Kieny MP, Cazenave JP, Thivolet J. [HIV envelope proteins are bound by human epidermal Langerhans cells by a binding site which differs from the site on the CD4 molecule, and are internalized by receptor endocytosis]. C R Acad Sci III. 1989;308(10):269-75. French. PubMed PMID: 2543485. Rivière Y, Tanneau-Salvadori F, Regnault A, Lopez O, Sansonetti P, Guy B, Kieny MP, Fournel JJ, Montagnier L. Multiple cytotoxic effector cells are induced by infection with the human immunodeficiency virus. Res Immunol. 1989 Jan;140(1):110-5; discussion 121. Review. PubMed PMID: 2657908. Ameisen JC, Guy B, Chamaret S, Loche M, Mouton Y, Neyrinck JL, et al. Antibodies to the nef protein and to nef peptides in HIV 1 infected seronegative individuals. AIDS Res Hum Retroviruses 1989;5:279-292. Chenciner N, Michel F, Dedaglio G, Langlade-Demoyen P, Hoffenbach A, Leroux A, et al. Multiple subsets of HIV-specific cytotoxic T lymphocytes in humans and in mice. Eur J Immunol 1989;19:1537-1544. Meneguzzi G, Kieny MP, Cerni C, Cuzin F, Lathe R. Antitumoral vaccination using vaccinia recombinants expressing papillomavirus early proteins. In "Papillomaviruses, UCLA Symposia on Molecular and Cellular Biology, New Series (eds. P Howley & T Broker) Alan R. Liss, Inc., New York 1989;124:1-8. Kieny MP, Lecocq JP, Lathe R, Girard M, Riviere Y, Montagnier L, et al. Tailoring the HIV envelope glycoprotein to improve immunogenicity. In "Vaccines 89" (eds. Lerner, Ginsberg, Chanock, Brown) Cold Spring Harbor Laboratory 1989;:177-183. Guy B, Kieny MP, Riviere Y, Girard M, Montagnier L, Lecocq JP, et al. Does HIV nef belong to the G protein family? Int J Sports Med 1989;165:285-288. Kieny MP. Structure et pathogénèse du virus de l'immunodéficience humaine. Ve Conférence Internationale sur le SIDA, Montréal. Association canadienne de Microbiologie Clinique et des Maladies Contagieuses, Bulletin de Nouvelles 1989;4:4-5. Tomasetto C, Gautier C, Hareuvent M, Wreschner DH, Kieny MP, Rio MC, et al. Towards a breast cancer vaccine? In "Breast Cancer: Progress in Biology, Clinical Management and Prevention", Proceedings of the International Association for Breast Cancer Research Conference, Tel-Aviv, Israel (eds. MA Rich, JC Hager, I Keydar) Kluwer Academic Publishers 1989;:216-222. Girard M, Kieny M P, Glickman JC, BarreSinoussi F, Montagnier L, Fultz P, et al. Candidate vaccines for HIV. In "Vaccines for Sexually Transmitted Diseases", Proceedings of the conference "Vaccines for Sexually Transmitted Diseases", Oxford (eds. A Meheus, RE Spier) Butterworths London 1989;:227-237.

1988

Guizani I, Kieny MP, Lathe R, Clertant P. Characterization of polyoma virus early proteins expressed from vaccinia virus recombinants. Gene. 1988 Dec 15;73(1):163-73. PubMed PMID: 2977356.

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Michel F, Hoffenbach A, Langlade-Demoyen P, Guy B, Girard M, Lecocq JP, Wain-Hobson S, Kieny MP, Plata F. HIV-specific T lymphocyte immunity in mice immunized with a recombinant vaccinia virus. Eur J Immunol. 1988 Dec;18(12):1917-24. PubMed PMID: 2905993. Salmon P, Olivier R, Riviere Y, Brisson E, Gluckman JC, Kieny MP, Montagnier L, Klatzmann D. Loss of CD4 membrane expression and CD4 mRNA during acute human immunodeficiency virus replication. J Exp Med. 1988 Dec 1;168(6):1953-69. PubMed PMID: 3264318; PubMed Central PMCID: PMC2189155. Pastoret PP, Brochier B, Languet B, Thomas I, Paquot A, Bauduin B, Kieny MP, Lecocq JP, De Bruyn J, Costy F, et al. First field trial of fox vaccination against rabies using a vaccinia-rabies recombinant virus. Vet Rec. 1988 Nov 5;123(19):481-3. PubMed PMID: 3201693. Kieny MP, Blancou J, Lathe R, Pastoret PP, Soulebot JP, Desmettre P, Lecocq JP. Development of animal recombinant DNA vaccine and its efficacy in foxes. Rev Infect Dis. 1988 Nov-Dec;10 Suppl 4:S799-802. PubMed PMID: 3206090. Brochier BM, Languet B, Blancou J, Kieny MP, Lecocq JP, Costy F, Desmettre P, Pastoret PP. Use of recombinant vaccinia-rabies virus for oral vaccination of fox cubs (Vulpes vulpes, L) against rabies. Vet Microbiol. 1988 Oct;18(2):103-8. PubMed PMID: 3218072. Kieny MP, Lathe R, Rivière Y, Dott K, Schmitt D, Girard M, Montagnier L, Lecocq J. Improved antigenicity of the HIV env protein by cleavage site removal. Protein Eng. 1988 Sep;2(3):219-25. PubMed PMID: 3237686. Clertant P, Kieny MP, Lecocq JP, Guizani I, Chambon P, Cuzin F, Lathe R. Recombinant polyoma--vaccinia viruses: T antigen expression vectors and anti-tumor immunization agents. Biochimie. 1988 Aug;70(8):1075-87. PubMed PMID: 2852508. Khalife J, Guy B, Capron M, Kieny MP, Ameisen JC, Montagnier L, Lecocq JP, Capron A. Isotypic restriction of the antibody response to human immunodeficiency virus. AIDS Res Hum Retroviruses. 1988 Feb;4(1):3-9. PubMed PMID: 3163253. Pastoret PP, Blancou J, Brochier B, Thomas I, Paquot A, Debruyn J, Costy F, Wolff F, Kieny MP, Languet B, et al. [Experience with antirabies vaccination of foxes using the oral route coordinated among several European countries and perspectives on the use of recombinant vaccinia-rabies virus]. Parassitologia. 1988 Jan-Apr;30(1):149-54. French. PubMed PMID: 3268767. Kieny MP, Lathe R. Vaccinia recombinants expressing foreign antigens: antiviral and antitumor immunity. In "Progress in Vaccinology" (PV2), (ed. GP Talwar) Springer Verlag Publishers New York 1988;(40):423-428. Guy B, Kieny MP, Riviere Y, Girard M, Montagnier L, Lecocq JP, et al. Functional analogies with cellular oncogene products imply a role for HIV F (3'orf) in cell regulation. In "Vaccines 88", New Chemical and Genetic Approaches to Vaccination (eds. Ginsberg, Brown, Lerner, Chanock ) Cold Spring Harbor Laboratory 1988;:311-316. Lecocq JP, Drillien R, Kieny MP. Virus de la vaccine recombinants : des vaccins de nouvelle génération. In Agriculture "Vaccination to control rabies in foxes" EUR 11439, Office for Official Publications of the European Communities, Luxembourg 1988;:105-111.

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Pastoret PP, Brochier B, Thomas I, Paquot A, Costy F, Kieny MP, et al. Premier essai du virus recombinant vaccine rage sur le terrain. In Agriculture "Vaccination to control rabies in foxes" EUR 11439 EN-FR, Office for Official Publications of the European Communities, Luxembourg 1988;:124-128. Blancou J, Pastoret PP, Brochier B, Kieny MP, Desmettre P, Artois M, et al. Vaccination des renards contre la rage avec le virus recombinant vaccine rage. In Agriculture, Office for Official Publications of the European Communities, EUR 11439 1988;:112-117. Brochier B, Languet B, Blanchou J, Thomas I, Kieny MP, Lecocq JP, et al. Innocuité du virus recombinant vaccine rage chez quelques espèces non cibles. In Agriculture, Office for Official Publications of the European Communities, EUR 11439 1988;:118-123. Ruprecht CE, Kieny MP. Development of a vaccinia-rabies glycoprotein recombinant virus vaccine. In "RABIES" (eds. JB Campbell, KM Charlton) Kluwer Academic Publishers, Boston 1988;(15):335-364. Wiktor TJ, Kieny MP, Lathe R. New generation of rabies vaccine. Vaccinia Rabies glycoprotein recombinant virus. In "Applied Virology Research" (eds. E Kurstak, RG Marusyk, FA Murphy, MHV. Van Regenmortel), Plenum Publishing Corporation, New York 1988;1:69-90. Michel F, Hoffenbach A, Langlade-Demoyen P, Guy B, Girard M, Lecocq JP, et al. A mouse model for vaccination against HIV. In "Technological Advances in Vaccine Development" UCLA Symposia on Molecular and Cellular Biology, New Series (ed. L. Lasky) Alan R. Liss, Inc. 1988;84:88-19. Kieny MP, Blancou J, Lathe R, Pastoret PP, Soulebot JP, Desmettre P, et al. Development of Animal Recombinant DNA Vaccine and Its Efficacy in Foxes. Clinical Infectious Diseases 1988;10(4):S799-S802.

1987

Guy B, Kieny MP, Riviere Y, Le Peuch C, Dott K, Girard M, Montagnier L, Lecocq JP. HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product. Nature. 1987 Nov 19-25;330(6145):266-9. PubMed PMID: 3118220. Lathe R, Kieny MP, Gerlinger P, Clertant P, Guizani I, Cuzin F, Chambon P. Tumour prevention and rejection with recombinant vaccinia. Nature. 1987 Apr 30-May 6;326(6116):878-80. PubMed PMID: 3033512. Kieny MP, Desmettre P, Soulebot JP, Lathe R. Rabies vaccine: traditional and novel approaches. Prog Vet Microbiol Immunol. 1987;3:73-111. Review. PubMed PMID: 3078836. Kieny MP, Rautemnn G, Girard M, Wain Hobson S, Montagnier L, Lecocq JP, et al. AIDS virus env expressed from vaccinia recombinants: protein processing and structural variants. In "Colloque des Cent Gardes" Retroviruses of Human AIDS and Related Animal Diseases 29-30 octobre 1986, Marnes La Coquette, France (eds. M Girard, G de Thé, L Valette), Publications Fondation Marcel Mérieux 1987;:146-148. Kieny MP, Rautmann G, Lecocq JP, Wain Hobson S, Montagnier L, Girard M, et al. Vaccinia-AIDS Recombinant Virus: Evidence for Shedding of gp120 (env) from the Cell Surface. In "Vaccines 87, Modern Approaches to New Vaccines" (eds. Chanock, Lerner, Brown, Ginsberg) Cold Spring Harbor, New York 1987;:242-249.

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Lathe R, Kieny MP, Gerlinger P, Guizani I, Clertant P, Cuzin F, et al. Polyoma Tumor Antigens Expressed from Vaccinia Virus : A Model for Tumor Immunity. In "Vaccines 87, Modern Approaches to New Vaccines" (eds. Chanock, Lerner, Brown, Ginsberg) Cold Spring Harbor, New York 1987;:425-430.

1986

Blancou J, Kieny MP, Lathe R, Lecocq JP, Pastoret PP, Soulebot JP, Desmettre P. Oral vaccination of the fox against rabies using a live recombinant vaccinia virus. Nature. 1986 Jul 24-30;322(6077):373-5. PubMed PMID: 3736663. Kieny MP, Rautmann G, Schmitt D, Dott K, Wain Hobson S, Girard M, et al. AIDS virus env protein expressed from a recombinant vaccinia virus. Biotechnology 1986;4:790-795. Kieny MP. Genetic engineering of viral vaccines. Swiss Biotech 1986;4:14-15. Guizani I, Clertant P, Kieny MP, Lathe R. Caractérisation des protéines précoces du virus du polyome exprimées par une construction virale hétérologue. In "5ème Ecole Franco Africaine de Biologie Moléculaire", Jerba, Tunisie (ed. Fakher Ben Hamida) 1986;:316-319. Lecocq JP, Kieny MP. Un nouveau vaccin antirabique développé par génie génétique. In "La Rage et la Brucellose dans le Bassin Méditerranéen et la Péninsule Arabe" (1986), Compte Rendu du Colloque organisé à Montpellier les 4-6 novembre 1985, Collection Fondation Marcel Mérieux 1986;:127-130. Kieny MP, et al. Acquired immunodeficiency syndrome virus env protein expressed from a recombinant vaccinia virus. Bio-technology, New York 1986;4(9):790-795.

1985

Lecocq JP, Kieny MP. La biologie moléculaire du virus rabique. Ann Med Vet 1985;129:249-261. Kieny MP, Lathe R, Lemoine Y, Drillien R, Wiktor T, Koprowski H, et al. Rage et génie génétique : développement de nouveaux vaccins. Ann Inst Pasteur/Virol 1985;136(E):391-403. Lecocq JP, Kieny MP, Curtis P, Lathe R. Genetically engineered rabies subunit vaccines. Dtsch Med Wochenschr 1985;:325-329. Lathe R, Kieny MP, Lecocq JP, Drillien R, Wiktor T, Koprowski J, et al. Immunization against rabies using a vaccinia-rabies recombinant virus expressing the surface glycoprotein. In "Modern Approaches to Vaccines: Molecular and Chemical Basis of Resistance to Parasitic, Bacterial and Viral Diseases" (eds. Lerner, Chanock, Brown) Cold Spring Harbor, New York 1985;:157-162. Wiktor T, MacFarlan RI, Kieny MP. Biologic activity of a vaccinia recombinant virus expressing the rabies virus glycoprotein. In "Improvements in Rabies Post Exposure Treatment" (eds. I Vodopija, KG Nicholson, S Smerkel, U Bijok) Zagreb Institute of Public Health, Zagreb 1985;:189-194. Kieny MP, Lathe R, Drillien R, Lemoine Y, Wiktor T, Lecocq JP, et al. Rabies protection via genetic engineering: expression of the surface glycoprotein in vaccinia virus and other vectors. In

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"Improvements in Rabies Post Exposure Treatment" (eds. I Vodopija, KH Nicholson, S Smerkel, U Bijok) Zagreb Institute of Public Health, Zagreb 1985;:195-199. Kieny MP. Vaccination contre la rage grâce à un virus de la vaccine recombinant exprimant la glycoprotéine rabique. In "La Rage 100 ans après la Découverte de Louis Pasteur", Réunion Commune avec la Société de Biopathologie Comparée et la Fondation Marcel Mérieux, Val de Grâce, Collection Fondation Marcel Mérieux 1985;1985:91-97.

1984

Kieny MP, Lathe R, Drillien R, Spehner D, Skory S, Schmitt D, Wiktor T, Koprowski H, Lecocq JP. Expression of rabies virus glycoprotein from a recombinant vaccinia virus. Nature. 1984 Nov 8-14;312(5990):163-6. PubMed PMID: 6548799. Wiktor TJ, Macfarlan RI, Reagan KJ, Dietzschold B, Curtis PJ, Wunner WH, Kieny MP, Lathe R, Lecocq JP, Mackett M, et al. Protection from rabies by a vaccinia virus recombinant containing the rabies virus glycoprotein gene. Proc Natl Acad Sci U S A. 1984 Nov;81(22):7194-8. PubMed PMID: 6095272; PubMed Central PMCID: PMC392104. Lathe R, Kieny MP, Skory S, Lecocq JP. Linker tailing: unphosphorylated linker oligonucleotides for joining DNA termini. DNA. 1984;3(2):173-82. PubMed PMID: 6327214. Lathe RF, Kieny MP, Schmitt D, Curtis P, Lecocq JP. M13 bacteriophage vectors for the expression of foreign proteins in Escherichia coli: the rabies glycoprotein. J Mol Appl Genet. 1984;2(4):331-42. PubMed PMID: 6330261. Lecocq JP, Kieny MP, Lemoine Y, Drillien R, Wiktor T, Koprowski H, et al. New rabies vaccines: recombinant DNA approaches. In "World's Debt to Pasteur", The Wistar Symposium series (eds. H Koprowski, SA Plotkin), Alan R Liss, Inc., New York 1984;3:259-272. Lathe R, Skory S, Kieny MP. Inserting new restriction sites by linker tailing. Focus 1984;(6):1-6. Lecocq JP, Sondermeyer P, Speck D, Courtney M, Tessier LH, Kieny MP, et al. Applications récentes du génie génétique : analyse de quelques paramètres et systèmes d'expression autres que E.coli. In "Génétique des Microorganismes Industriels", 9e Colloque de la Société Française de Microbiologie, Paris 1984;:125-140.

1983

Kieny MP, Lathe R, Lecocq JP. New versatile cloning and sequencing vectors based on bacteriophage M13. Gene. 1983 Dec;26(1):91-9. PubMed PMID: 6323254.