litdoc29090027_20140116215642 (1)

VERSAflux System

Operating Instructions

Original instructions

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Table of Contents51 Introduction ..........................................................................................................61.1 Important user information .............................................................................................................91.2 Associated documentation ..............................................................................................................

102 Safety instructions ...............................................................................................112.1 Safety precautions ...............................................................................................................................202.2 Labels .........................................................................................................................................................232.3 Emergency procedures ......................................................................................................................272.4 Recycling information .........................................................................................................................282.5 Declaration of Hazardous Substances (DoHS) ........................................................................

313 System description ..............................................................................................323.1 Overview ...................................................................................................................................................333.2 VERSAflux systems layout ................................................................................................................343.2.1 Illustrations of VERSAflux 120 system ..................................................................................383.2.2 Illustrations of VERSAflux 400 system ..................................................................................423.3 Standard equipment ...........................................................................................................................433.3.1 Skid and electric cabinet .............................................................................................................453.3.2 Automation .......................................................................................................................................463.3.3 Connections and drains ..............................................................................................................483.3.4 Feed pump and feed line ............................................................................................................513.3.5 Retentate line ...................................................................................................................................553.3.6 Permeate line ...................................................................................................................................573.4 Optional equipment .............................................................................................................................583.4.1 Dummy filters ..................................................................................................................................593.4.2 Hose kit ...............................................................................................................................................603.5 Hollow fiber (HF) configuration .......................................................................................................613.5.1 VERSAflux 120 HF configuration .............................................................................................623.5.2 VERSAflux 400 HF configuration .............................................................................................633.5.3 HF cartridges ....................................................................................................................................653.6 Meters and sensors .............................................................................................................................663.7 Flow charts ..............................................................................................................................................673.7.1 External connections ....................................................................................................................693.7.2 Flow diagrams ................................................................................................................................723.8 Control system .......................................................................................................................................

944 Installation ............................................................................................................954.1 Site requirements ..................................................................................................................................974.2 Transport ..................................................................................................................................................994.3 Unpack VERSAflux ................................................................................................................................

1014.4 Setup ...........................................................................................................................................................1024.4.1 Assembly ............................................................................................................................................1044.4.2 Process component connections ............................................................................................1064.4.3 Power supply ...................................................................................................................................

VERSAflux System Operating Instructions 29-0900-27 AA 3

Table of Contents

1095 Run preparations .................................................................................................1115.1 Sample handling ...................................................................................................................................1145.2 Starting VERSAflux ...............................................................................................................................1155.3 Filter installation ....................................................................................................................................1165.4 Priming the rotary lobe pump .........................................................................................................

1176 Operation ..............................................................................................................1196.1 Perform the run .....................................................................................................................................1216.2 PID control and feedback tuning ...................................................................................................1226.2.1 Introduction ......................................................................................................................................1246.2.2 Using PID-control ...........................................................................................................................1256.2.3 More information ...........................................................................................................................1276.3 Procedures after use ...........................................................................................................................

1287 Maintenance .........................................................................................................1297.1 User maintenance schedule ...........................................................................................................1307.2 Cleaning ....................................................................................................................................................1327.3 Storage ......................................................................................................................................................1347.4 Disassembly and assembly .............................................................................................................

1388 Troubleshooting ...................................................................................................

1429 Reference information ........................................................................................1439.1 Specifications .........................................................................................................................................1479.2 Process wetted materials .................................................................................................................1489.3 Chemical resistance ............................................................................................................................1509.4 More information ..................................................................................................................................

151Index .......................................................................................................................

4 VERSAflux System Operating Instructions 29-0900-27 AA

Table of Contents

1 Introduction

Purpose of this documentThe Operating Instructions provide you with the instructions needed to install, operateand maintain VERSAflux in a safe way.

Scope of this documentThis manual is valid for all variants of standard VERSAflux systems. The system configu-ration for your system is described in the General Specification and on the system label.Detailed information regarding Hollow Fiber Cartridge is not covered.

About this chapterThis chapter contains important user information, description of safety notices, regulatoryinformation, a general description of VERSAflux and its intended use, and a list of asso-ciated documentation.

In this chapterThis chapter contains the following sections:

See pageSection

61.1 Important user information

91.2 Associated documentation


1 Introduction

1.1 Important user information

Read this before operatingVERSAflux

All users must read the entire Operating Instructions before installing, operating ormaintaining VERSAflux.

Always keep the Operating Instructions at hand when operating VERSAflux.

Do not operate VERSAflux in any other way than described in the user documentation.If you do, you may be exposed to hazards that can lead to personal injury and you maycause damage to the equipment.

Intended use of VERSAfluxVERSAflux systems are intended for pilot to production scale biological separations.

The systems are configured to operate hollow fiber cartridges suited for microfiltrationapplications such as cell clarification/harvesting, or hollow fibers for ultrafiltration appli-cations, such as protein concentration and diafiltration in downstream unit operations.

VERSAflux is not suitable for operation in a potentially explosive atmosphere or for han-dling flammable liquids.

VERSAflux shall not be used in any clinical procedures, or for diagnostic purposes.

WARNINGDo not operate VERSAflux in any other way than described in theOperating Instructions.


1 Introduction1.1 Important user information

PrerequisitesIn order to operate VERSAflux safely, and according to the intended purpose, the followingprerequisites must be met:

You should be acquainted with the use of bioprocessing equipment and with thehandling of biological materials.

The system must be installed according to the instructions in Chapter 4 Installation,on page 94.

Safety noticesThis user documentation contains WARNINGS, CAUTIONS and NOTICES concerning thesafe use of the product. See definitions below.

Warnings

WARNINGWARNING indicates a hazardous situation which, if not avoided,could result in death or serious injury. It is important not to proceeduntil all stated conditions are met and clearly understood.

Cautions

CAUTION

CAUTION indicates a hazardous situation which, if not avoided,could result in minor or moderate injury. It is important not to pro-ceed until all stated conditions are met and clearly understood.

Notices

NOTICE

NOTICE indicates instructions that must be followed to avoiddamage to the product or other equipment.



Notes and tipsA note is used to indicate information that is important for trouble-free andoptimal use of the product.

Note:

A tip contains useful information that can improve or optimize your procedures.Tip:

Typographical conventionsSoftware items are identified in the text by bold italic text. A colon separates menu levels,thus File:Open refers to the Open command in the File menu.

Hardware items are identified in the text by bold text (for example, Power).



1.2 Associated documentation

System-specific documentationIn addition to the Operating Instructions, the documentation package supplied withVERSAflux also includes detailed specifications and traceability documents.

The most important documents in the documentation package with regard to technicalaspects of VERSAflux are:

Purpose/ContentsAbbreviationDocument

Schematic overview of the entire processflow, all components and instrumentsand the control system.

P&IDPiping and Instrumenta-tion Diagram

Technical data for the system.GSGeneral Specification

Physical layout. Provides all dimensionaldata.

ADAssembly Drawing

List of spare parts available from GEHealthcare.

SPLSpare Part List

Major components specificationEQLEquipment List


1 Introduction1.2 Associated documentation

2 Safety instructions

About this chapterThis chapter describes safety precautions and emergency shutdown procedures forVERSAflux. The labels on the system and information regarding recycling are also de-scribed.

Important

WARNINGBefore installing, operating or maintaining VERSAflux, all usersmust read and understand the entire contents of this chapterto become aware of the hazards involved.

Failure to do this may cause human injury or death, or damage tothe equipment.


See pageSection

112.1 Safety precautions

202.2 Labels

232.3 Emergency procedures

272.4 Recycling information

282.5 Declaration of Hazardous Substances (DoHS)


2 Safety instructions

2.1 Safety precautions

IntroductionThe safety precautions in this section are grouped in the following categories:

General precautions, on page 11

Flammable liquids and explosive environment, on page 12

Personal protection, on page 13

Installing and moving, on page 14

Power supply, on page 16

System operation, on page 16

Maintenance, on page 18

Some of the safety precautions in this chapter may concern components orsituations described in other VERSAflux product documents.

Note:

General precautions

WARNINGPerform a risk assessment for any risks due to the process or pro-cess environment. Evaluate the effects the use of VERSAflux andthe operational processes may have on the classification of thehazardous area. The process might cause the area to increase orthe zone classification to change. Implement the risk reductionmeasures needed, including use of personal protection equipment.

WARNINGMake sure that all installation, maintenance, operation and inspec-tion is carried out by qualified personnel who are adequatelytrained, understand and adhere to local regulations and the oper-ating instructions, and have a thorough knowledge of VERSAfluxand the entire process.


2 Safety instructions2.1 Safety precautions

WARNINGVERSAflux is designed for fixed installation. No main power supplycable plug is provided. Connect the system directly to the electricalcabinet or use other type of fixed installation.

WARNINGDo not operate VERSAflux in any other way than described in theOperating Instructions.

WARNINGProtective earth. VERSAflux must always be connected toprotective earth when energized.

WARNINGDo not use VERSAflux if it is not working properly, or if it has sufferedany damage, for example:

damage to the power cord or its plug

damage caused by dropping the equipment

damage caused by splashing liquid onto it

Flammable liquids and explosiveenvironment

WARNING: EXPLOSION HAZARDFlammable liquids.VERSAflux isnotapproved to handle flammablefluids.



Personal protection

WARNINGWhen using hazardous chemical and biological agents, take allsuitable protective measures, such as wearing protective glassesand gloves resistant to the substances used. Follow local and/ornational regulations for safe operation and maintenance ofVERSAflux.

WARNINGPersonal Protective Equipment (PPE).Whenever packing, unpack-ing, transporting or moving VERSAflux, wear:

Protective footwear, preferably with steel lining.

Working gloves, protecting against sharp edges.

Protective glasses.

WARNINGOnly personnel authorized by GE Healthcare may open the cabinetdoors. There is high voltage inside the cabinet that can causehuman injury or death.

CAUTION

Do not touch the system while pumping fluid through the systemthat has a temperature above the normal working temperature.Do not touch the system until you are sure that this can be donewithout risk and when all components in the system have reachedthe normal working temperature range.

CAUTION

Avoid spillage and overflow. Make sure that the waste tubing isinserted in an appropriate waste container and secured in place.



CAUTION

Use ear protection whenever working close to the system in oper-ation.

Installing and moving

WARNINGVERSAflux must be installed and prepared by GE Healthcare per-sonnel or third party authorized by GE Healthcare.

WARNINGMove transport crates. Make sure that the forklift has capacity tosafely lift the crate weight. Make sure that the crate is properlybalanced so that it will not accidentally tip when moved.

WARNINGHeavy object.Because of the significant weight of VERSAflux, greatcare must be taken not to cause squeezing or crushing injuriesduring movement. At least two, but preferably three or more, per-sons are recommended when moving the unit.

WARNINGAccess to power switch and power cord. The power switch mustalways be easy to access. The power cord must always be easy todisconnect.



CAUTION

To prevent bacterial growth, VERSAflux may be partly filled withdenatured Ethanol (18% C2H5OH (Ethanol), 2% C3H7OH (Isopropanol)and 80% H2O (water)) or 0.1 M NaOH (Sodium Hydroxide) at delivery.The mixture is hazardous to humans if consumed. Flush out thedenatured Ethanol or Sodium Hydroxide before assembling, testingor integrating VERSAflux into the intended process context.

CAUTION

The wheels of VERSAflux should be locked during normal use. Thewheels should be unlocked only when moving the unit.

CAUTION

Make sure that all tubing, hoses and cables are placed so that therisk for tripping accidents is minimized.

CAUTION

VERSAflux is designed for indoor use only.

CAUTION

Do not use VERSAflux in a dusty atmosphere or close to sprayingwater.

CAUTION

Make sure that correct air pressure is always maintained. Too highor too low air pressure may be hazardous and may cause erroneousresults and leakage.



Power supply

WARNINGVERSAflux must always be connected to a grounded power outlet.

WARNINGNational Codes and standards (NEC, VDE, BSI, IEC, UL etc.) and localcodes outline provisions for safely installing electrical equipment.Installation must comply with specifications regarding wire types,conductor sizes, plug, branch circuit protection and disconnectdevices. Failure to do so may result in personal injury and/orequipment damage.

WARNINGAll electrical installations must be performed by authorizedpersonnel only.

System operation

WARNINGSafe distance. Always maintain a safe distance fromVERSAflux during drainage or other activities that may involvesplashing.

WARNINGBefore operation, all process connections and the piping systemmust be tested for leakage at maximum pressure for continuedprotection against injury risks due to fluid jets, burst pipes or poten-tially explosive atmosphere.



WARNINGNever exceed the operating limits stated in this document and onthe system label. Operation of VERSAflux outside these limits maydamage equipment and bodily harm or death may occur.

WARNINGEmergency stop. Pressing the EMERGENCY STOP will not shut offmains power to the cabinet.

WARNINGPower failure. During a power failure, or if the EMERGENCY STOPbutton is pressed, VERSAflux may remain pressurized. Opening aline or vessel at this point could result in the release of potentiallyhazardous process or cleaning fluid, and cause bodily harm.

When recovering from a power failure or emergency shutdown,make sure all lines and vessels are depressurized before opening.

WARNINGAlarm signals. All alarm signals must be set within the limitsspecified in the system documentation. Pressure and temperaturecontrol must be activated while the system is in use to prevent thepiping system to leak or break.

NOTICE

Only use chemicals that have been proven not to be harmful tothe wetted parts of the unit.

NOTICE

Make sure that large particles are prevented from entering theVERSAflux system during operation, otherwise the filters may be-come clogged and the feed pump may malfunction.



NOTICE

Do not start the rotary lobe pump before it is primed.

Maintenance

WARNINGThe electric cabinet doors may only be opened when VERSAflux istaken out of operation and subject to LOCK OUT / TAG OUT.

WARNINGOnly personnel authorized by GE Healthcare may perform service,installation, and maintenance of components inside the VERSAfluxcabinet.

WARNINGLOCKOUT / TAGOUT! Before any maintenance or decommission-ing work is performed on VERSAflux, make sure that:

it is empty and depressurized.

it is disconnected from process feed, electrical power andpneumatic supply.

it is prevented from accidentally becoming re-energized duringmaintenance.

it is clearly tagged as taken out of operation.

all process wetted areas are clean and decontaminated.



WARNINGFor continued protection against injury risks due to fluid jets, burstpipes or potentially explosive atmosphere, the piping system mustbe tested for leakage at maximum pressure:

After assembly or maintenance

Before operation or CIP

CAUTION

Do not climb on any parts of VERSAflux except where clearly al-lowed. Follow local regulations and make sure that equipment isproperly secured when inspecting VERSAflux at high level.

NOTICE

Although system filter type reconfiguration can be performed bya properly skilled user, GE Healthcare recommends that a GEHealthcare service engineer is assigned for this work.

Contact your GE Healthcare representative for more informationon changing filter configurations if required.



2.2 Labels

IntroductionThis section describes the various labels on VERSAflux and their meaning.

System label illustrationThe illustration below shows an example of a system label.

Actual data is specific for each individual system and may vary from systemto system.

Note:


2 Safety instructions2.2 Labels

System label description

DescriptionLabel text

This symbol indicates that the product contains hazardousmaterials in excess of the limits established by the Chinesestandard SJ/T11363-2006 Requirements for ConcentrationLimits for Certain Hazardous Substances in Electronics.

System serial number.Serial number

Manufacturing year.Year of manufacture

Max. system pressure at temperature.Max. systempressure/temperature

Pneumatic supply pressure requirement.Pneumatic supply

Overall protection class, ingress protection according toIEC 60529. This cover all components of the system exceptthe electric cabinet.

Overall protection class

Supply voltage system.Supply voltage system

Supply voltage pump.Supply voltage pump

Supply voltage frequency.Frequency

Max. current consumption system.Max. currentconsumption system

Max. current consumption pump.Max. currentconsumption pump

Protection class.Protection class



Safety labelsThe table below describes the various safety labels that may be found on VERSAflux.

DescriptionSymbol/text

WARNING! Read the user documentation before usingthe system. Do not open any covers or replace partsunless specifically stated in the user documentation.

WARNING! High Voltage. Always make sure that thesystem is disconnected from electric power beforeopening the cabinet doors or disconnecting any electricdevice.

EMERGENCY STOP label, yellow with black text.(emergency stop button is red).

Refer to Section 2.3 Emergency procedures, on page 23for further information regarding the emergency stop.

WARNING! High voltage inside cabinet! Authorizedpersonnel only! For continued protection against fire,only replace fuses with the same type and rating.For continued protection

against fire replace only withsame type and rating of fuse

High voltage inside cabinet!Authorised personnel only!

WARNING!

CAUTION! Hot surface. Risk of burning injuries.

CAUTION! Use ear protection whenever working closeto the system in operation.

CAUTION! Do not use water jets directly on the system.

CAUTION! Pressure control valve shall be set to 5.5 7 bar g for instrument air supply.

CAUTION!Pressure control valve

shall be set to 5.5 7 bar g

for instrument airsupply



2.3 Emergency procedures

IntroductionThis section describes how to perform an emergency shutdown of VERSAflux, and theresult in the event of power failure.

Precautions

WARNINGEmergency stop. Pressing the EMERGENCY STOP will not shut offmains power to the cabinet.

WARNINGPower failure. During a power failure, or if the EMERGENCY STOPbutton is pressed, VERSAflux may remain pressurized. Opening aline or vessel at this point could result in the release of potentiallyhazardous process or cleaning fluid, and cause bodily harm.

When recovering from a power failure or emergency shutdown,make sure all lines and vessels are depressurized before opening.


2 Safety instructions2.3 Emergency procedures

Emergencystopbuttonandmainpower switch

VERSAflux 120 - front

A

VERSAflux 120 - rear

AB



VERSAflux 400

A

B

FunctionPart

EMERGENCY STOP buttonA

MAIN SWITCH, powerB

Emergency shutdown

ResultActionStep

Press the EMERGENCY STOPbutton (A).

1 Pumps stop immediately.

The built-in computer (HMI) and PLCremain powered.

Red indicator lamp is lit.

Buzzer is activated.

No data is lost.

If required, also switch off themains power supply using theMAIN SWITCH, power (B), dis-connect the power cord orswitch off the fixed power sup-ply circuit breaker.

2 The entire system, including the HMIand PLC, becomes powerless.

Data and run status may be lost.



Power failureThe system power is lost if the MAIN SWITCH on the cabinet is turned off or the mainscable is disconnected or the power supply is lost.

Pump stops if the electrical power to the system is lost. All valves will immediately revertto default positions. Any data that has not been saved at that time may be lost.

Restart after emergencyshutdown or power failure

Follow the instruction below to restart VERSAflux after emergency shut down or powerfailure.

ActionStep

Make sure that the condition that caused the power failure or emergencystop is corrected.

1

2

Reset the EMERGENCY STOP button by twisting it clock-wise.

Press the Start button on the HMI.3

NOTICE

If the system does not restart as expected, contact your local GEHealthcare representative for assistance.



2.4 Recycling information

IntroductionThis section contains information about the decommissioning of VERSAflux.

DecontaminationVERSAflux shall be decontaminated before decommissioning and all local regulationsshall be followed with regard to scrapping of the equipment.

Disposal, general instructionsWhen taking VERSAflux out of service, the different materials must be separated andrecycled according to national and local environmental regulations.

Recycling of hazardoussubstances

VERSAflux contains hazardous substances.

Disposal of electricalcomponents

Waste electrical and electronic equipment must not be disposed as unsorted municipalwaste and must be collected separately. Please contact an authorized representativeof the manufacturer for information concerning the decommissioning of equipment.


2 Safety instructions2.4 Recycling information

2.5 Declaration of Hazardous Substances (DoHS)

IntroductionThe following product pollution control information is provided according to SJ/T11364-2006 Marking for Control of Pollution caused by Electronic Information Products.

SJ/T11364-2006

Symbols used in pollution controllabel

MeaningLabel

This symbol indicates the product contains hazardous materials in ex-cess of the limits established by the Chinese standard SJ/T11363-2006Requirements for Concentration Limits for Certain Hazardous Sub-stances in Electronic Information Products. The number in the symbolis the Environment-friendly Use Period (EFUP), which indicates the periodduring which the toxic or hazardous substances or elements containedin electronic information products will not leak or mutate under normaloperating conditions so that the use of such electronic informationproducts will not result in any severe environmental pollution, anybodily injury or damage to any assets. The unit of the period is Year.

In order to maintain the declared EFUP, the product shall be operatednormally according to the instructions and environmental conditionsas defined in the product manual, and periodic maintenance schedulesspecified in Product Maintenance Procedures shall be followed strictly.

Consumables or certain parts may have their own label with an EFUPvalue less than the product. Periodic replacement of those consumablesor parts to maintain the declared EFUP shall be done in accordancewith the Product Maintenance Procedures.

This product must not be disposed of as unsorted municipal waste,and must be collected separately and handled properly after decom-missioning.


2 Safety instructions2.5 Declaration of Hazardous Substances (DoHS)

MeaningLabel

SJ/T11363-2006

List of hazardous substancesandtheir concentrations

Indication for each major part if substance exceeds limit

MeaningValue

Indicates that this toxic or hazardous substance contained in all of thehomogeneous materials for this part is below the limit requirement inSJ/T11363-2006.

O

SJ/T11363-2006

Indicates that this toxic or hazardous substance contained in at leastone of the homogeneous materials used for this part is above the limitrequirement in SJ/T11363-2006.

X

Data listed in the table represents best information available at thetime of publication

SJ/T11363-2006



List of hazardous substances

Hazardous substance

Componentname

PBDE

PBB

Cr6+

Cd

Hg

Pb

00000XVERSAflux



3 System description

About this chapterThis chapter provides an overview of the technical properties of VERSAflux.


See pageSection

323.1 Overview

333.2 VERSAflux systems layout

423.3 Standard equipment

573.4 Optional equipment

603.5 Hollow fiber (HF) configuration

653.6 Meters and sensors

663.7 Flow charts

723.8 Control system


3 System description

3.1 Overview

GeneralThese Operating Instructions cover the VERSAflux 120 and 400 systems.

VERSAflux is a series of cross flow filtration (CFF) systems that utilize WinCC Advanced(TIA Portal) V11 software for semi automation, with data logging capabilities over theentire cross flow process.

VERSAflux systems are intended for pilot to production scale biological separations.

The systems are configured to operate hollow fiber cartridges suited for microfiltrationapplications such as cell clarification/harvesting, or hollow fibers for ultrafiltration appli-cations, such as protein concentration and diafiltration in downstream unit operations.

Material complianceAll plastic and polymer materials that come in contact with buffers and samples arecompliant with FDA CFR 21 part 177, or USP Class VI.

Used materials are traceable back to their production batches.

You can find information about the design and materials used in your system in theSystem-specific documentation, on page 9.


3 System description3.1 Overview

3.2 VERSAflux systems layout

In this sectionThis section contains the following subsections:

See pageSection

343.2.1 Illustrations of VERSAflux 120 system



3 System description3.2 VERSAflux systems layout


VERSAflux 120: Front view

1 2

3

46

7

8

5

FunctionPart

EMERGENCY STOP buttons1

Human machine interface (HMI)2

Indicator lamps3

Electrical connectors4

Cartridge drain outlet connection5

Feed inlet connection6

Permeate outlet connection7

Retentate outlet connection8


3 System description3.2 VERSAflux systems layout3.2.1 Illustrations of VERSAflux 120 system

VERSAflux 120: Rear view

1011

12

13

14

15

9

FunctionPart

Retentate drain connection9

Swivelling caster with brake (4 pcs)10

Adjustable floor supports11

Electric cabinet12

System label13

MAIN SWITCH, power14

Connectors on top15




VERSAflux 120: Externalconnectors

Electrical connectors

1 2 3 4 5 6 12

8 9 10 117

FunctionConnector

Weight Signal Input1

Compressed air to PCV-3412

PT-1133

TT-1614

FIT-142 Signal5

FIT-142 Power6

Emergency stop HS37

PT-1118

PT-1129

FIT-141 Signal10



FunctionConnector

FIT-141 Power11

USB connector12

Top connectors

1 2 3

FunctionConnector

Compressed air inlet1

Main power supply2

Power supply for P-2013





VERSAflux 400: Front view

1

2

3

4

6

5

7

FunctionPart

EMERGENCY STOP buttons1

Human machine interface (HMI)2

Indicator lamps3

MAIN SWITCH, power4

Feed inlet connection5

Permeate outlet connection6

Retentate outlet connection7



VERSAflux 400: Rear view

9

10

11

8

12

FunctionPart

Adjustable floor support (2 pcs)8

Swivelling caster with brake (4 pcs)9

System label10

Connectors on top11

Retentate drain connection12




VERSAflux 400: Externalconnectors

Side panel connectors

1 2 3 4 5 6

13

7

8 9 10 11 12

FunctionConnector

Power Converter to Motor1

Load cell Signal Input2

Compressed air to PCV-3413

PT-1134

TT-1615

FIT-142 Signal6

FIT-142 Power7

Emergency stop HS38

PT-1119

PT-11210



FunctionConnector

FIT-141 Signal11

FIT-141 Power12

USB connector13

Top connectors

1 2 3

FunctionConnector

Compressed air inlet1

Main power supply2

Power supply for P-2013




3.3 Standard equipment

About this sectionThis chapter provides an overview of the technical properties of VERSAflux.


See pageSection

433.3.1 Skid and electric cabinet

453.3.2 Automation

463.3.3 Connections and drains

483.3.4 Feed pump and feed line

513.3.5 Retentate line

553.3.6 Permeate line


3 System description3.3 Standard equipment


Skid

The rigid stainless steel structure supports and protects all process components andthe electric cabinet. The structure is designed for handling in a production environmentand is easy to move and keep clean.

The structure occupies a small box-shaped space that makes it easy to fit into any loca-tion in the production facility.




Electric cabinet

The electric cabinet contains all electrical and pneumatic equipment. When the door isclosed, the entire cabinet is ingress protected according to IP54.


3 System description3.3 Standard equipment3.3.1 Skid and electric cabinet

3.3.2 Automation

Control system

The VERSAflux System is automated by means of the WinCC Advanced (TIA Portal) V11Ccontrol platform. Once the required control mode is selected and parameters entered,a user can safely operate the system.

HMI

The HMI is built in to the cabinet and has high IP protection from the environment.

The HMI automatically starts when the system power is turned on, no specific startingprocedure is required for the HMI.

For HMI specifications, refer to the product documentation package.

User interfaceThe display and input devices are ergonomically designed for use in a clean productionenvironment.

CommunicationsAll communication with controlled components mounted outside the cabinet uses theHART industry standard communication protocol and hardware.



3.3.2 Automation


DescriptionA standard VERSAflux system is provided with the following process connections:

Feed inlet

Filter inlet, outlet and drain connections

Retentate outlet

Permeate outlet

Pump outlet located before filters and meters.


3 System description3.3 Standard equipment3.3.3 Connections and drains

Illustration

VERSAflux 120 VERSAflux 400

B1

P1

P2

P3

P4

P5

FunctionLabel on systemPart

Feed inlet to systemFEEDB1

Retentate outletRETENTATEP1

Permeate outletPERMEATEP2

Feed drain pointFEED DRAINP3

Cartridge drain pointCARTRIDGE DRAINP4

Retentate drain pointRETENTATE DRAINP5





DescriptionThe main purposes of the feed line is to transfer product (or feed) from the recirculationtank, to the filter, FILTER and to raise the pressure of the feed so that correct transmembrane pressure (TMP), filter pressure and feed flow is achieved. This is done by thefeed pump, P-201.

To protect the system against over pressure, one pressure sensor, PT-111 is installedafter the pump. If the system pressure rises over pre-set value, an alarm will be triggeredin HMI and the pump will stop, to make sure that the system is not subject to over pres-sure. The feed line for VERSAflux 120 has a temperature sensor, TT-161 (optional), installedbefore the pressure sensor.

The feed line can be drained through the HV-301 valve.

The internal diameter of the feed line is selected to keep the flow velocity of the productwithin a favorable range with regard to the flow range for each system.


3 System description3.3 Standard equipment3.3.4 Feed pump and feed line

Feed: VERSAflux 120

B1

P-201

HV-301

TT-161

PT-111

F

P3

ME1


Feed inletFEEDB1

Spare port on feed lineME1ME1

Feed pumpP-201P-201

Feed drain valveHV-301HV-301

Feed drainFEED DRAINP3

Temperature sensorTT-161TT-161

Pressure sensorPT-111PT-111

Hollow fiberFILTERF




Feed: VERSAflux 400

B1

P-201

HV-301PT-111

F

P3

ME1


Feed inletFEEDB1

Spare port on feed lineME1ME1

Feed pumpP-201P-201

Feed drain valveHV-301HV-301

Feed drainFEED DRAINP3


Hollow fiberFILTERF


3 System description3.3 Standard equipment3.3.4 Feed pump and feed line


DescriptionParticles / molecules too large to pass through the filter pores are retained by the filteras retentate.

Retentate is led out from the filter (FILTER) through the retentate connection and thenguided to the retentate outlet.

A sensor for pressure, PT-112 is located on the retentate outlet line. For VERSAflux 400System, a sensor for temperature, TT-161 (optional), is located on the retentate line.

TMP is controlled by the pressure control valve PCV-341 (optional) regulated by controlsoftware, or is controlled by the manual diaphragm valve PCV-331 in alternative option.

The entire retentate line can be shut off by closing the retentate valve HV-302 (optional)combined with PCV-341 (optional), or by closing PCV-331 in alternative option.

The retentate line is drained through the drain valve HV-306.

All retentate drain valves on VERSAflux 120 and 400 use uniformed tag, HV-303.




Retentate: VERSAflux 120

PCV-341 HV-302FIT-141PT-112F

P1P5HV-303

PCV-331

FIT-141PT-112F

P1P5HV-303



Retentate drainRETENTATE DRAINP5

Hollow fiberFILTERF


Retentate drain valveHV-303HV-303


3 System description3.3 Standard equipment3.3.5 Retentate line


Flow sensorFIT-141FIT-141

Manual diaphragm valvePCV-331PCV-331

Pressure control valvePCV-341PCV-341

Manual butterfly valveHV-302HV-302

Retentate: VERSAflux 400

PCV-341 HV-302FIT-141PT-112F

P1P5 TT-161HV-303

PCV-331FIT-141PT-112F

P1P5 TT-161HV-303






Retentate drainRETENTATE DRAINP5

Hollow fiberFILTERF


Retentate drain valveHV-303HV-303

Flow sensorFIT-141FIT-141

Temperature sensorTT-161TT-161

Manual diaphragm valvePCV-331PCV-331

Pressure control valvePCV-341PCV-341

Manual butterfly valveHV-302HV-302


3 System description3.3 Standard equipment3.3.5 Retentate line

3.3.6 Permeate line

DescriptionParticles / molecules small enough to pass through the filter pores are collected aspermeate.

Permeate is led out from the filter through the permeate connection (FILTER) and guidedto the permeate outlet through valve HV-304.

Sensors for pressure, PT-113 (optional), and flow, FIT-142 (optional) are located on thepermeate outlet line. The temperature sensor, TT-161, for VERSAflux 120 is located onthe Feed line.

Permeate: VERSAflux 120

FIT-142 PT-113 FP2 HV-304



3.3.6 Permeate line

Permeate: VERSAflux 400

FIT-142 PT-113 FP2 HV-304


Hollow fiberFILTERF


Permeate flow meterFIT-142FIT-142

Manual diaphragm valveHV-304HV-304

Permeate outletPERMEATEP2


3 System description3.3 Standard equipment3.3.6 Permeate line

3.4 Optional equipment

About optionsThe VERSAflux suite of filtration systems comes in a basic setup, as described in previoussections.

Additionally, a selection of options are available to extend the functionality of the instru-ment.


See pageSection

583.4.1 Dummy filters

593.4.2 Hose kit


3 System description3.4 Optional equipment

3.4.1 Dummy filters

DescriptionDummy filters allow the system to operate with liquid but without filtering capability.These can be either purpose made dummies or decommissioned filters.

Usage can be for tests and set-up where running the system is required but actual filtra-tion is not.

Contact your local GE Healthcare representative for more information regarding dummyfilters.

Illustration: Dummy filters


3 System description3.4 Optional equipment3.4.1 Dummy filters

3.4.2 Hose kit

DescriptionTo connect the feed tank to a corresponding VERSAflux 120 or 400 system, a set of hosesis required. Hose kits are available as an option from GE Healthcare. The hoses are madeof reinforced PT-cured silicone and are designed to meet the tank and system specifica-tions.

Illustration: Hose kit

Basic hose kitThe basic kit contain the following hoses:

Cartridge permeate port to permeate line;

Cartridge drain port to cartridge drain line.

Optional hose kitsOptionally, depending on the tank and VERSAflux system configuration, the followinghoses can be included if requested:

Feed from transfer pump to tank

Feed from tank to system

Retentate from system to tank

Permeate recycle from system to tank


3 System description3.4 Optional equipment

3.4.2 Hose kit

3.5 Hollow fiber (HF) configuration

OverviewWhen the VERSAflux systems are operated with hollow fiber cartridges, required compo-nents of the piping system must be installed.

The retentate line must be in the upper position.


See pageSection

613.5.1 VERSAflux 120 HF configuration


633.5.3 HF cartridges


3 System description3.5 Hollow fiber (HF) configuration


Illustration: Hollow fiber sizes 75,55 and 35

21

4

2 2

4 43 3

75 55 35

An optional spool piece kit is needed to mount size 55 and 35 hollow fibers to the system,see feed line extension pipes in the next table.

Description of HF components

FunctionPart

Retentate line1

Hollow fiber cartridges2

Feed line extension pipe3

HF cartridge drain hose4





Illustration: Hollow fiber sizes 85,65 and 45

21

4

2 2

4 43 3

85 65 45

An optional spool piece kit is needed to mount sizes 65 and 45 hollow fibers to the system,see feed line extension pipes in the Description of HF components, on page 61.

Description of HF components

FunctionPart

Retentate line1

Hollow fiber cartridges2

Feed line extension pipe3

HF cartridge drain hose4


3 System description3.5 Hollow fiber (HF) configuration3.5.2 VERSAflux 400 HF configuration

3.5.3 HF cartridges

Illustration: HF cartridge

Description of HF cartridgesHollow fiber (HF) cartridges contain numerous very thin hollow fibers glued together atthe ends.

Each fiber is open at the ends and the feed flows inside the fibers and out the other end.The size of the pores determines the filtering characteristics of the cartridge, that is, thecut-off size for particles that either will be retained or filtered out with the permeate.

The permeate flows outside the fibers and is collected through one of the side connectors.

Available types of HF cartridgesVERSAflux is designed to adopt hollow fiber cartridges of different sizes. These cartridgesare described in the Ambio hollow fiber filter user guide, GE Healthcare article no.18-1165-30, and in theHollow fiber selection guide , GE Healthcare article no. 18-1165-29.



3.5.3 HF cartridges

HF cartridge draining

VERSAflux 120 VERSAflux 400

Hollow fibre cartridges are provided with two connections to the permeate compartment,one at each end.

When mounted vertically, which is the case for all VERSAflux systems, the bottom con-nection serves as a drain for the permeate. This allows for more complete recovery ofthe permeate.


3 System description3.5 Hollow fiber (HF) configuration3.5.3 HF cartridges

3.6 Meters and sensors

Pressure sensorsThree pressure sensors are provided. The pressure sensor, PT-111, provides pressuredata for the feed pump outlet and filter feed inlet pressure, PT-112, measures retentatepressure and PT-113 (optional) measures permeate pressure.

The pressure drop (delta P) is calculated by the control software by subtracting the re-tentate pressure from the feed pressure.

The transmembrane pressure (TMP) is calculated by the control software by subtractingthe permeate pressure from the average of the feed and retentate pressure.

The pump outlet pressure sensors also provide overpressure protection for the feedpump and system.

Flow sensorsTwo flow sensors are provided. A magnetic flow meter for the retentate, and a magneticflow meter for the permeate flow.

FIT-141 (optional) measures the retentate flow and FIT-142 (optional) measures thepermeate flow.

The feed flow is calculated by adding the permeate flow to the retentate flow.

TemperatureOn VERSAflux 120 system, temperature is measured in the feed line by sensor TT-161(optional).

On VERSAflux 400 system, temperature is measured in the retentate line by sensorTT-161 (optional) .


3 System description3.6 Meters and sensors

3.7 Flow charts


See pageSection

673.7.1 External connections

693.7.2 Flow diagrams


3 System description3.7 Flow charts


IntroductionThis section describes the external connections between VERSAflux 120 and 400 andthe optional tank.

Connection diagram

P1

P2

P5

P4

P3

B1 ME1

Legend

DescriptionColorSymbol

OutletsBlue

InletsOrange

Interface pointsGreen




Battery limits"Battery limits" represent all interface points between the VERSAflux and the customerprocess plant.

System battery limits require hose connections not provided by GE Healthcare.

Normally, the user provides hoses for these connections. Refer to Section9.1 Specifications,on page 143 for details of hose and connection types and sizes.

DescriptionLocationTag

Feed inletSystemB1

Retentate outletSystemP1

Permeate outletSystemP2

Feed drainSystemP3

Cartridge drainSystemP4

Retentate drainSystemP5


3 System description3.7 Flow charts3.7.1 External connections

3.7.2 Flow diagrams

VERSAflux 120: Flow diagram

F

ME1

P

P

P F

PT-112

PT-113

FIT-142 H

V-30

4

HV-

302

HV-

301

PT-111

P-20

1

P3

P2

FILT

ER

B1

P1

HV-303

FILT

ER

P5

T TT-161

HV-304.4

HV-305.4

HV-304.1

HV-305.1 P4

HV-304.3

HV-305.3

HV-

305

HV-

306

FIT-141

PCV-

341

PCV-

331



3.7.2 Flow diagrams

VERSAflux 400: Flow diagram

F T

ME1

P

P

P F

PT-112

PT-113

FIT-142

HV-

304

HV-

302

HV-

301

PT-111

P-20

1

P3

P2

FILT

ER

B1

P1

HV-303

P5

TT-161

FILT

ER

HV-304.4

HV-305.4

HV-

304.

1 H

V-30

5.1

P4

HV-304.3

HV-305.3

HV-

305

HV-

306

FIT-141

FILT

ER

FILT

ER

HV-

306.

1 H

V-30

7.1

HV-306.4

HV-307.4

HV-

307

HV-

308

HV-306.3

HV-307.3 PC

V-34

1

PCV-

331


3 System description3.7 Flow charts3.7.2 Flow diagrams

Component description

DescriptionTag

FeedB1

RetentateP1

PermeateP2

Feed drainP3

Cartridge drainP4

Retentate drainP5

System pumpP-201

Feed pump outlet pressure meterPT-111

Retentate pressure meterPT-112

Permeate pressure meter (optional)PT-113

Temperature meter, VERSAflux 120 on Feed, VERSAflux 400 onRetentate (optional)

TT-161

Retentate flow meter (optional)FIT-141

Permeate flow meter (optional)FIT-142

Manual butterfly valve HV-302 used together with PCV-341, onRetentate (alternative option PCV-331)

HV-302

Pneumatic pressure control valve PCV-341 together with HV-302,on Retentate (alternative option PCV-331)

PCV-341

Manual pressure control valve, on Retentate (alternative optionPCV-341 together with HV-302)

PCV-331

Not included in the systemTANK



3.7.2 Flow diagrams

3.8 Control system

IntroductionVERSAflux is operated and monitored using the HMI (Human machine interface) that isdisplayed on the screen. The screens and the structure of the HMI are described below.All set range and data in this chapter are for VERSAflux 400 system.

Cabinet indicators

1 2 3

FunctionColorLabelPart

Power onGreenPower1

Pump onYellowRun2

AlarmingRedAlarm3


3 System description3.8 Control system

Structure of the HMI

Welcome screen

ActionStep

Start the VERSAflux1

Result: The welcome screen appears.

Wait until the system is ready, as shown by the System Starting countdownand appearance of the Logon button.

2



ActionStep

Click on the Logon button.3

Result:

Enter the correct information for User and Password, then press OK.4

Result:

Confirm that USB memory stick is installed on the cabinet, then click YES.5

Result: The system moves on to the Home screen.



Home screenThe Home screen provides an overview and is the main control screen for systemoperation.

Displays ...Area/IndicatorPart

Important parameters that always display onscreen

Head display area1

Flow SchemePiping & Flow diagram2

Instrument Reading

Instrument live data trendLive trend3

Alarm informationInstance Alarm andAcknowledge area

4

Instance AlarmAcknowledge and Resetarea

5

Warning and System events

Acknowledge and reset

Pump Control mode selectionControl mode area6

PCV Control parameters

Start and stop for the pumpOn and Off buttons7

Switch between different screensFoot display area8



Head display areaThe Head display area shows up on all screens. It only displays the selected importantparameters.

Deci-mal

RangeDescriptionName

10.0~100.0%Pump actual speed set pointPump Set

20.00~6.00 barPT-111 actual valueFeed Pressure

20.00~4.00 barTrans-membrane pressureTMP

20.00~4.00 barDelta P = Feed pressure - Permeatepressure

Delta P

0-Accumulated retentate flow volume, thisvalue can only be reset manually.

Acc. VOL1:Retentate

0-Accumulated permeate flow volume, thisvalue can only be reset manually.

Acc. VOL2:Permeate

--Batch running time. It starts from pumprunning, can be paused by alarm signals,and reset manually.

Acc. Time

--Time reading from the system HMI.System time

--Display logged on user name.User



Piping and Flow Diagram areaThe flow scheme area displays as Piping& FlowDiagram (PFD), as shown in the followingexample:

All instruments with corresponding settings can be found in this area, as shown in thefollowing table (Range data for VERSAflux 400 system):

UnitDecimalRangeInstallationName

Bar in default20.00~6.00DefaultPT-111

Bar in default20.00~6.00DefaultPT-112

Bar in default20.00~4.00OptionalPT-113

Degree Celsius10.0~150.0OptionalTT-161

l/min10.0~600.0OptionalFIT-141

l/min10.0~95.0OptionalFIT-142

%010~100OptionalPCV-341

%10.0~100.0DefaultP-201

kg10.0~1200.0OptionalWIT-176

If an optional instrument is not selected, it will disappear from the PFD areatogether with its corresponding settings and related processes.

Note:



Related processesOptional instrument

PT-113 PT-113 reading

PT-113 alarm setting

TMP value

TMP control

TMP alarm setting

TT-161 TT-161 reading

TT-161 alarm setting

FIT-141 FIT-141 reading

FIT-141 alarm setting

Constant retentate flow control

Constant retentate flow control alarm setting

Acc. VOL1

FIT-142 FIT-142 reading

FIT-142 alarm setting

Acc. VOL2

PCV-341 PCV-341 setting

Delta P control

Delta P control alarm setting

WIT-176 WIT-176 reading

WIT-176 alarm setting



Live trend display area

The Live Trend area displays instance values for the following:

Displayed live trend of ...Name

Retentate flow meter (FIT-141) readingFIT-141

Feed pressure meter readingPT-111

Pressure difference between Feed and RetentateDelta P

Temperature readingTT-161

Instance Alarm and Acknowledge area

The InstanceAlarm&Acknowledgearea indicates instance alarm, warnings and systemevents. The alarm background will become yellow when acknowledged.



Acknowledge and Reset area

The Acknowledge & Reset area comprises the buttons that are used to acknowledgeand reset information, as shown in the following table.

FunctionButton

Reset retentate accumulated flowReset Acc. VOL 1

Reset permeate accumulated flowReset Acc. VOL 2

Reset accumulated batch timeReset Acc. Time

Restore system after alarm has disappearedReset Fault

Alarms acknowledged by operator, after which the alarm dis-appears from the window

Alarm Ack.

Control mode area

The Control mode area displays the different control modes that can be selected.

Clicking the icon allows selection of the control mode to be used.

The parameter table below allows the user to choose the proper control parameters,control modes and settings:



Control group 1:

Deci-mal

Set RangeDescriptionPumpControlGroup

10.0~100.0%Manual pump speed control set point.Pump Set

20.00~4.00 barDelta P control set point,

Delta P = P_feed P_retentate.

Delta P Set

10.0~400.0l/min

Retentate flow control set point,

Constant flow control.

Flow Set

Control group 2:

Deci-mal

RangeDescriptionPCV ControlGroup

110.0~100.0%Manual PCV valve opening control setpoint.

PCV Set

20.00~4.00 BarTMP control set point,

TMP = (P_feed + P_retentate)/2 P_per-meate.

TMP Set

Start and Stop Buttons

The Start and Stop Buttons area allows the user to start and stop the pump.

FunctionName

Start pump if the system is OK.On button (green)

Stop pumpOff button (red)



Foot display area

The Foot Display area shows up on all screens. It displays the different screen selectionpossibilities for the system.

FunctionDescriptionName

Switch to Home page.Page ButtonHome

Switch to instrument alarm/warning settingspage.

Page ButtonSetting1

Switch to miscellaneous settings including PID,dry run protection, etc.

Page ButtonSetting2

Switch to history trend page.Page ButtonTrend

Switch to alarm log page.Page ButtonAlarmLog

Switch to user administration page.Page ButtonUserAdmin

Switch between English and Chinese.Function ButtonLanguage

Log off the current user.Function ButtonLog Off

Exit current runtime with admin authority.Function ButtonExit



Setting1 screenThe Setting1 screen includes theAlarmandWarning settings range and enable/disablefunctions for the installed in-line instruments.

Click the Setting1 button in the Foot display area to go to the Setting1 screen.

RemarkDescriptionArea / IndicatorPosi-tion

Red: DisabledCorresponding alarmwill be disabled

Alarm disable switches1

Green: Enabled

Need Admin account tomodify; data will be re-tained during poweroff.

User settings for eachinstrumentAlarm/Warning

Alarm parameter set-tings

2

The detailed information for instrument Alarm/Warning settings are shown in the followingtable:



UnitDecimalRangeTag

bar20.00~6.00PT-111 HA

bar20.00~6.00PT-111 LA

bar20.00~6.00PT-111 HW

bar20.00~6.00PT-111 LW

bar20.00~6.00PT-112 HA

bar20.00~6.00PT-112 LA

bar20.00~6.00PT-112 HW

bar20.00~6.00PT-112 LW

bar20.00~4.00PT-113 HA

bar20.00~4.00PT-113 LA

bar20.00~4.00PT-113 HW

bar20.00~4.00PT-113 LW

Degree Celsius10.0~150.0TT-161 HA

Degree Celsius10.0~150.0TT-161 LA

Degree Celsius10.0~150.0TT-161 HW

Degree Celsius10.0~150.0TT-161 LW

l/min10.0~600.0FIT-141 HA

l/min10.0~600.0FIT-141 LA

l/min10.0~600.0FIT-141 HW

l/min10.0~600.0FIT-141 LW

l/min10.0~95.0FIT-142 HA

l/min10.0~95.0FIT-142 LA

l/min10.0~95.0FIT-142 HW

l/min10.0~95.0FIT-142 LW

kg10.0~1200.0WIT-176 1 HA

kg10.0~1200.0WIT-176 LA

kg10.0~1200.0WIT-176 HW

kg10.0~1200.0WIT-176 LW

1 WIT-176 is the load cell signal from a tank. It is valid only when the system is connected to a specific tank and the EnableTank button is enabled on the Setting2 page.



Setting2 screenThe Setting2 screen includes theAlarm andWarning settings range, the enable/disablefunctions and the PID settings for the different control modes together with the Miscfunction settings (such as unit switch from bar to PSI, tank load cell enable/disablefunction, Buzzer enable/disable function, Compress air alarm enable/disable function,and the Abnormal flow alarm enable/disable function).

Click the Setting2 button in the Foot display area to go to the Setting2 screen.

RemarkDescriptionArea/Indicator

Posi-tion

Red: DisabledCorresponding alarm will be disabled fordifferent control modes:

Alarmdisableswitches

1

Green: Enabled

Delta P

TMP Alarm

Retentate Flow Control (RFC Alarm )

Need Admin ac-count to modify;data will be keptduring poweroff.

User settings for corresponding Alarm/Warning for different control modes:

Delta P

TMP

Retentate Flow Control (RFC)

Alarmparametersettings

2



RemarkDescriptionArea/Indicator

Posi-tion

Detailed PIDtuning refers toSection 6.2 PIDcontrol andfeedback tuning,on page 121.

PID parameter settings for different con-trol modes:

Delta P

TMP

Retentate Flow Control (RFC)

PIDParametersettings

3

Red: DisabledDifferent kinds of functions enable/dis-able switches:

Misc.switches

4

Green: Enabled

Unit switch: bar-PSI

Enable Tank

Buzzer enable/disable

Compress air alarm enable/disable(Pneumatic)

Abnormal flow alarm enable/disable(Flow Abnormal)

Once the Enable Tank button has been enabled, a Tank will appear on thePFD on the Home page. Otherwise the Tank is hidden.

Note:



Detailed information for instrument Alarm/Warning settings is shown in the followingtable:

UnitDecimalRangeTag

bar in default10.0~4.0Delta P HA

bar in default10.0~4.0Delta P LA

bar in default10.0~4.0Delta P HW

bar in default10.0~4.0Delta P LW

bar in default10.0~4.0TMP HA

bar in default10.0~4.0TMP LA

bar in default10.0~4.0TMP HW

bar in default10.0~4.0TMP LW

l/min10.0~400.0RFC HA

l/min10.0~400.0RFC LA

l/min10.0~400.0RFC HW

l/min10.0~400.0RFC LW



Trend screenAll the installed instruments historical data trend can be found on the Trend page.

Click the Trend button in the Foot display area to go to the Trend screen.

In the trend diagram area, the Y axis to the left shows the measurement for flowrateand temperature (FIT-141, FIT-142, TT-161), and the Y axis to the right shows the mea-surement for pressure (PT-111, PT-112, PT-113, TMP, Delta P).

The user can drag the marker over the trend curve to read the process data from thedata table below the trend curve area.



AlarmLog screenThe AlarmLog screen records all the warnings and alarms that ocur.

Click the AlarmLog button in the Foot display area to go to the AlarmLog screen.

All warnings will display with a white background. When an alarm occurs, the backgroundwill turn yellow. It will remain yellow when the user acknowledges the alarm and willturn blue when the fault is corrected and the system is reset.



The UserAdmin screenTheUserAdmin screen provides tools to edit specific user and administrator informationas shown in detail below.

Click the UserAdmin button in the Foot display area to go to the UserAdmin screen:

Important information for all users:

OP (operator)Admin (adminnistrator)

Change own password

Modify own logoff time

Create new user account

Add/Remove/Edit all user informa-tion (e.g. change own and otherspassword)

Modify logoff time for all users

Change alarm and warning set-tings

Functions

Change alarm range set-ting

Create new account

Exit the program

NoneRestric-tions

Default Password: 000000Default Password: 123456Remark

Default logout: 60 minutesDefault logout: 5 minutes



Create new user account

ActionStep

Click the User pane.1

Result: the User pane is activated and a keyboard pops up:

Enter the new user name.2

Click the Password pane.3

Result: The Change password window appears:



ActionStep

Enter the new password and confirm it.4

Click the Group pane.5

Result: the Group pane is activated:

Choose the correct acount level for the new user.6

Click the Logoff time pane.7

Result: the Logoff time pane is activated and a keyboard pops up:

Enter the automatic Logoff time for the new user in minutes (default).8



Functional ButtonsThe Language, LogOffand Exitbuttons in the Foot display area are all functional buttons.

LanguageBy clicking the Language button in the Foot display area the user can switch betweenEnglish and Chinese language display.

Log OffBy clicking the Log Off button in the Foot display area, the current user will be loggedoff from the system and the user information in the Head display area will disappear,although the system will keep the current working condition.

When the operation of the system software is resumed, the user will be asked to log onto the system.

ExitOnly the administrator can exit the current filtration software interface and go back tothe Window CE interface by clicking the Exit button.

Data recordingThe system operation data will be recorded on the USB memory stick in *.csv file format.

All the instrument readings will be recorded as Process Data[X].csv, where X stands fora number, starting from 0, 1, 2, etc.

All the warnings and alarms will be recorded as Alarm Log[X].csv, where X stands for anumber, starting from 0, 1, 2, etc.

The *.csv files can be opened and edited by the Microsoft Excel software on anyother computer.



4 Installation

About this chapterThis chapter provides information required to enable users and service personnel tounpack, install, move and transport VERSAflux.

Precautions

WARNINGBefore attempting to perform any of the procedures described inthis chapter, you must read and understand all contents of thecorresponding section(s) in the Section 2.1 Safety precautions, onpage 11 as listed below:

General precautions, on page 11

Personal protection, on page 13

Installing and moving, on page 14

Power supply, on page 16


See pageSection

954.1 Site requirements

974.2 Transport

994.3 Unpack VERSAflux

1014.4 Setup


4 Installation

4.1 Site requirements

Space and floor loadFor space and floor requirement, see external dimensions and weights in Section 9.1Specifications, on page 143.

Make sure that the floor can handle the VERSAflux weight at fully loaded conditions.Please observe that for the weight to be equally distributed over all wheels, the floormust be level and without irregularities.

In order to allow convenient working conditions for the operator, sufficient spaceshould be provided at all sides of the combined VERSAflux system and VERSAfluxtank when installed at the intended production location.

Ambient environmentAvoid:

Direct sunlight.

Strong magnetic or electric fields.

Vibrations.

Corrosive gas.

Dust.

Electrical powerRefer to Section4.4.3 Power supply, on page106andSection9.1 Specifications, onpage143for power, voltage and phase requirements.

Compressed air Dry and particle free air for system supply.

Refer to Section 9.1 Specifications, on page 143 regarding capacity requirements.

Refer to Connect compressed air supply, on page 102 regarding connections to theinstrument.


4 Installation4.1 Site requirements

Media supplyRefer to Section9.1 Specifications, on page143 regarding requirements for media supplyand delivery.

Supply must be arranged so that piping dimensions, piping lengths, valves and heightdifferences do not obstruct processing.

ComputerVERSAflux 120 and 400 has an industrial built-in HMI installed.


4 Installation4.1 Site requirements

4.2 Transport

In the transport crate

WARNINGMove transport crates. Make sure that the forklift has capacity tosafely lift the crate weight. Make sure that the crate is properlybalanced so that it will not accidentally tip when moved.

WARNINGPersonal Protective Equipment (PPE).Whenever packing, unpack-ing, transporting or moving VERSAflux, wear:

Protective footwear, preferably with steel lining.

Working gloves, protecting against sharp edges.

Protective glasses.

Use a pallet jack or fork-lift with a minimum capacity to match the empty weight of thesystem plus the transport crate. Refer to Section9.1 Specifications, on page143 regardingsystem weight.

Make sure that intended openings and apertures are large enough to allowpassage of the crate when lifted from the floor for transport.

Note:


4 Installation4.2 Transport

Unpacked

WARNINGHeavy object.Because of the significant weight of VERSAflux, greatcare must be taken not to cause squeezing or crushing injuriesduring movement. At least two, but preferably three or more, per-sons are recommended when moving the unit.

VERSAflux can be rolled by hand on hard and level surface with wheel brakes released.

If the floor quality does no allow rolling the VERSAflux on its own wheels, it can bemoved with a pallet jack or fork-lift.

For minimum door aperture size, refer to Section 9.1 Specifications, on page 143.


4 Installation4.2 Transport

4.3 Unpack VERSAflux

Tools required Suitable lifting device, forklift or similar. Refer to Section9.1 Specifications, on page143

for dimensions and weight to be handled.

13 mm wrench (or ratchet with 13 mm socket).

Electrical screwdriver no. 2 bit.

Knife.

Lever.

Visual inspectionCheck:

that all equipment is enclosed in the crate according to the packing list.

the equipment for any apparent damage and document carefully if found.

If any equipment is missing or damages are found, contact your GE Healthcare repre-sentative immediately.

Precautions

CAUTION



4 Installation4.3 Unpack VERSAflux

General unpacking instructionsRefer to the unpacking instructions attached to the outside of the crate whenunpacking the crate. In absence of the unpacking instructions, follow thegeneral unpacking instructions below.

Note:

ActionStep

Remove the front, side and back panels by loosening the bolts.1

Remove the accessories and documentation package.2

Use a forklift or similar lifting equipment to move the system out from thecrate.

3


4 Installation4.3 Unpack VERSAflux

4.4 Setup


See pageSection

1024.4.1 Assembly

1044.4.2 Process component connections

1064.4.3 Power supply

Precautions

CAUTION



4 Installation4.4 Setup

4.4.1 Assembly

Lock the wheelsThe VERSAflux system is delivered fully assembled. No further specific assembly proce-dures are required.

After positioning the system at its designated location, lock the wheels (figure).

Connect compressed air supply

Locate your air inlet as in the previous figure, and connect to the compressed air supply.

For air supply requirements, refer to Compressed air, on page 95.


4 Installation4.4 Setup4.4.1 Assembly

Control system

VERSAflux 120 and 400 are delivered with the WinCC Advanced (TIA Portal) V11 systemcontrol software.

WinCC Advanced (TIA Portal) V11 is pre-installed and configured on the built-in HMI withno additional specifications required.

For more information see Section 3.3.2 Automation, on page 45.

Filter setupIf the system is configured for the intended filter type, there is no need for further config-uration upon arrival at the process site or inbetween processing runs.

If the system needs to be reconfigured for different size of HF cartridges, refer to Sec-tion 7.4 Disassembly and assembly, on page 134.

Feed pump and CFF filterprotection

To protect the system from feed containing particles that may clogg the CFF-filter ordamage the pump, use upstream normal flow filtering as described in Section5.1 Samplehandling, on page 111.



4.4.1 Assembly


IntroductionThis section provides guidelines for the connection of process components to VERSAflux.

Recommended hoses andconnections

Use hoses delivered with the tank to connect the tank and the system to each other.

Use customer supplied hoses to connect the combined tank and system assembly batterylimits to the plant interface points.

Refer to Section9.1 Specifications, on page143 for information regarding connection typeand size.

General guidelines forconnections

Use piping or tubing that has an internal diameter sufficient for the flow rate specified.The inner diameter of the tubing and its connections should be greater than or equalto the corresponding diameter of the system.

Inlet and outlet containers shall be located and arranged so that back pressure andsuction height remains within system specification limits, refer to Section9.1 Specifi-cations, on page 143 or the Section 1.2 Associated documentation, on page 9 (GS).

Keep the tubing lengths as short as possible to minimize hold-up volume in the sys-tem.

Route the tubing to minimize the risk of tripping when operating the instrument andconnected device.

If the hoses should be violently pulled, for example caused by an accidental tripping,they should be checked for damage, leakage and mechanical rigidity before contin-uing operation.


4 Installation4.4 Setup4.4.2 Process component connections

The chemical properties of the tubing used shall meet or exceed the propertiesspecified in Section 9.3 Chemical resistance, on page 148.




4.4.3 Power supply

Power requirementsThe power supply requirements are specified in Section 9.1 Specifications, on page 143.

InstallationConnect the system power cord to either:

A fixed power supply by means of a permanent connection which can be detached

only by the use of a tool.

An EN 60309-2 compliant connector.

Grounding and protective earth The protective earth wire must be connected to system ground.

Ground impedance must conform to the requirements of national and local industrialsafety regulations and/or electrical codes.

If the leak current exceeds 10 mA, a high leakage current earth connection must beprovided and confirmed before connecting power supply. Refer to the product doc-umentation package for information regarding the leak current for your system.

The integrity of all ground connections must be periodically checked.

Circuit breakerA circuit breaker must be present in the fixed power supply.

Breaking the power supply to the VERSAflux system by using this breaker must beequivalent to disconnecting the power cord for a non-fixed connected instrument.

Power supply cableThe mains power supply cable is shielded LFLEX of

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