PROGRAM*!

Presentations*

Private*presentations*

8:30'9:00!Reception!9:00'9:10!Director!Speech!9:10'10:40:!!! Session'1:'Cancer'therapies'targeting'and'innovation!Moderators:!Nadège*Gaborit*(AP)!

Romain'Lanotte''Analysis!of!HER4!isoforms:!Toward!a!therapeutic!targeting!with!antibody!in!cancerology!

Sara'Cherradi''Optimization!and!mechanism!of!action!of!a!therapeutic!monoclonal!antibody!against!Claudin'1!

Rana'Melhem''Targeting!Transferrin!Receptor!1!(TFR1)!in!Pancreatic!Cancer!

Leila'El'Kebriti''Autophagy!as!a!determinant!of!drug!resistance!in!cancer!

Déborah'Caucheteur''New!formats!of!human!recombinant!antibody!libraries*

Matthieu'Gassiot''Identification!of!determinants!of!metabolism!and!transport!involved!in!the!sensitivity!of!IKs!in!

prostate!cancer!Eve'Combes''

Markers!of!resistance!to!chemo!and!anti'EGFR!therapy!in!colorectal!cancer!Charline'Ogier'''

A!new!therapeutic!perspective!for!pancreatic!cancer:!targeting!of!EGFR!family's!ligands!expressed!by!tumor!and!microenvironment!!

Emmanuel'Dehayes''Imaging!and!radioimmunotherapy!of!ovarian!cancer!using!radiolabeled!monoclonal!antibodies!

10:40'11:10!Break'–!stand!visit!and!Posters!presentations!10:10'11:20:!Alliance'Biosciences:!Hypoxic!cell!culture!a!growing!trend!in!tissue/cell!!11:20'12:45:!! !!!!!!!!!Session'1:'Signaling'pathways'and'regulation!Moderators:!Benoît*Bordignon*(FC)!

Khalil'Batnini!!Dissection!of!E4F1!function!on!cell!cycle!checkpoints!and!DNA!repair!in!response!to!genotoxic!

stress!Berfin'Seyran''

E4F1'mediated!control!of!pyruvate!dehydrogenase!activity!is!essential!for!normal!skin!homeostasis!

Nabiya'Boubacar'Ali''Caractérisation!d'une!nouvelle!enzyme!de!la!voie!épigénétique!H4K20me1!

Rémi'Logeay''Understanding!the!cooperation!between!Notch!and!the!polarity!determinant!Scribble!during!

neoplasia!

Flash*presentations*

PROGRAM*!

Flash*presentations*

Presentations*

!Nour'Sfeir''

Crosstalk!of!the!transcription!factor!RIP140!with!the!Notch!signaling!pathway!in!colon!cancer!Mona'Houhou''

Characterization!of!a!Cancer!Stem!cells!enriched!subpopulations!and!role!of!EMT!Regulators!in!basal'Breast!Cancer!Cell!Plasticity'

Pascale'Palassin''Role!of!the!transcriptional!coregulator!RIP140!in!hereditary!colorectal!cancer!

Meryem'Brital''Identification!of!novel!proteins!involved!in!tumor!invasion!

Toufic'Kassouf''The!E'cadherin/catenin!complex!and!the!intercellular!adhesion!of!breast!cancer!cells!are!positively!regulated!via!phosphorylation!by!the!Syk!tyrosine!kinase!in!breast!cancer!cells!

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12:45'14:15!Lunch'break!'!stand!visit!and!Posters!presentations!14:15'16:05:!!! Session'2:'Cancer'therapies'targeting'and'innovation!Moderators:!Clément*Barjon*(NB)!

Alexandre'Pichard''Targeted!radiotherapy!of!Non!Hodgkin!B!cell!Lymphoma!using!anti'CD37!and!anti'CD20!

antibodies!radiolabelled!with!177Lutetium:!a!radiobiological!approach!Cécile'Galmiche''

Monoclonal!antibody!screening!by!click!chemistry!Joelle'Azzi''

Identification!of!kinase!inhibitors!as!alternatives!for!the!treatment!of!metastatic!castration'resistant!prostate!cancers!

Amaelle'Otandault'Havivy''Hypoxia!induced!DNA!releasing!in!different!cancer’s!types!

Riad'Ladjohounlou''Assessment!of!targeted!and!non'targeted!effects!during!alpha'RIT!of!small!volume!peritoneal!

carcinomatosis!using!²¹²Pb'labeled!mAbs!

Hanane'mansouri''Combinatorial!strategy!targeting!the!tumor!microenvironment!of!triple'negative!breast!cancer!

with!anti'protease!antibody!Maeva'Chauvin''

AMHR'I/AMHR'II!cell!signaling!and!gynecological!cancers!therapeutics!using!antibodies!Laetitia'They''

Strengthening!the!immunomodulatory!effects!of!anti'tumor!monoclonal!antibody:!Study!of!potentiating!effects!of!combined!therapies!and!analysis!of!the!mechanisms!involved!

Emilie'Renaud''Colon!cancer!resistance!to!Irinotecan'based!therapy:!determining!MAPK!p38!isoforms!

contribution!and!pharmacological!targeting!

Flash*presentations*

PROGRAM*!

Flash*presentations*

Flash*presentations*

Presentations*

!Session'2:'Signaling'pathways'and'regulation'

Moderators:*Romain*Larivé*(PC)!

Emile'Lakis''Roles!of!EMT!transcription!factors!in!controlling!cell!clonal!dynamics!and!invasiveness!during!

emergence!of!tumor!resistance!in!breast!cancer!subtypes.!Amanda'Abi'Khalil''

Phenotypic!plasticity!in!HMECs!Fanny'Izard''

H4'K20!methyltransferases!in!epigenetic!mechanisms!associated!with!cancer!!

15:55'16:05!:!Affymetix'eBioscience':'Détermination!de!biomarqueurs!en!matrices!complexes:!Du!FFPE!à!l’ADN!circulant!/!QuantiGene!Plex!=!Quantification!de!l’expression!génique!en!analyse!multiplex!utilisant!la!technologie!Luminex®!xMAP®'16:05'16:35!Break!'!stand!visit!and!Posters!presentations!16:35'17:35:!! !!!!Session!2:!Signaling'pathways'and'regulation!!!

Tom'Egger''Impact!of!ATR/Chk1!mutations!on!replication!stress!response!in!colorectal!cancer!

Elodie'Forest''Expanding!the!Magi!protein!complex!during!AJ!remodelling!in!the!Drosophila!pupal!eye!

Madi'Cissé''Role!of!MDM2!in!the!metabolism!and!the!tumor!growth!of!Liposarcoma!

Mouna'Triki''Regulation!of!RIP140!expression!by!the!Wnt!signaling!pathway!in!colorectal!and!gastric!cancer!

cells!Mohamed'Hamyeh''

Protein!tyrosine!phosphatase!PTPL1/!PTPN13:!Important!regulator!of!tumor!invasion!in!breast!cancer!

Shefqet'Hadjari''HP1!are!essential!epigenetic!regulators!of!liver!homeostasis!

17:35'18h:!Last!Break!'!stand!visit!and!Posters!presentations!

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