Lombardi Comprehensive
Cancer Center
Cancer Informatics Summit
2/21/2013
Subha Madhavan, Ph.D. Director, Innovation Center for Biomedical Informatics
Georgetown University Medical Center
Director, Clinical Research Informatics
Lombardi Comprehensive Cancer Center
Vincent T. Lombardi
• Famous professional
football coach
• Fell ill at Washington
Redskins’ practice on
Georgetown
University field
• Treated for cancer at
Georgetown
• Cancer Center
named in his honor
“Winning isn’t everything, it’s
the only thing.”
Lombardi – At a glance
• Established in 1970
• In 1974, Georgetown Lombardi became the 16th
NCI-designated Comprehensive Cancer Center
• Over $100M in research funding ever year
– $35M CCSG + peer-reviewed funding base
• 94 full members; 186 cancer-connected faculty
members
• 4 Research programs & 9 Shared resources
• 220 ongoing trials
Key Accomplishments
• Development of human papillomavirus (HPV) vaccine to prevent cervical cancer – R. Schlegel
• Discovery of GADD-4 DNA repair gene – A. Fornace
• Nuclear hormone receptor networks in breast cancer – R. Clarke
• Monoclonal antibody therapy – L. Weiner
General Organizational Structure
Director (Weiner)
Clinical Care (Marshall)
Clinical Research (Giaccone)
Population Sciences
(Mandelblatt)
Basic Research (Wellstein)
Minority Health (Campbell)
Shared Resources
(Byers)
Administration (VanderHoek)
Deputy Director (Atkins)
Another view of the cancer center
AD Minority
Health
AD Shared
Resources
AD
Administration
Network
Representative
AD
Population
AD Clinical
AD
Basic/Transl
Deputy Dir
Director EAC IAC
BC ET
MO CPC
Sh
are
d R
eso
urc
es
Trial Oversight
Ad
min
istr
atio
n
Research Education
Community
Advisory Council
Informatics @ Georgetown
Innovation Center for Biomedical Informatics (ICBI) http://icbi.georgetown.edu/
• Faculty – 5
• Senior staff members – 5
• Research associates – 5
• Support staff – 2
• Consultants – 5
• Students/Trainees - 2
Expertise in bioinformatics, clinical informatics, biomathematics,
biostatistics, clinical genomics, molecular biology, high-throughput
molecular assays, enterprise class software development, data
management, data security, & project management
Informatics Org Chart
CTSA PI CCSG SR Director
Dean of Research
ICBI Director
Highthroughput
omics
Technology
Development
Health IT ChemiInformatics Data Coordination & Biocuration
Clinical Research
Informatics
Director, Operations Financial Analyst
Office Manager
Communications/
Scientific writing
Cancer Center Director
FTEs supporting Cancer Center – 8
Total FTEs - 22
Informatics Funding
$3.5M Total Annual Funding in 2012
Lombardi Information Architecture
(current & future)
Integrated Data Environment:
G-DOC Links to Many of Data Silos
G-DOC
Pathway Studio
•Systems biology
•Literature
Ingenuity Analysis
•Pathways, GO, Variants
RedCap
Clinical Research
EHR’s
JMol/Marvin
• Molecule Visualization
Cytoscape
•Visualization networks
JBrowse
•Genome Visualization
Disease Classification
Tools
https://gdoc.georgetown.edu
Over 330 registered
users from six countries
~250 unique hits/month
Making Patients Part of Healthcare Through
Technology Innovations
Amazon S3
Bucket
Genomic Data
De-identified Clinical data
Amazon EC2
Compute
Instances
Amazon
Glacier Vault
MongoDB EC2
Instances
Genome Data
Oracle RDS
Instance
Clinical Data
G-DOC Web
Portal
User PC
Next Generation Sequencing
Big Data Analytics on the Cloud
Clinical Research
Biospecimen Basic/Traslational
Clinical Education • Informatics
education
• Partnerships
• Joint grants
• Joint appointments
• Contracted services
• Shared resources
• Medical internships
• Shared IP
• Joint publications
Informatics for
Discovery, Clinical Research, Clinical Care
• ‘omics’ data analysis
• EHR/PHR integration
• Biomarker discovery
• Disease
classification
• Genotype-Phenotype
correlation
• Biospecimen
management and
analysis
• Technology/method
development
Website : https://icbi.georgetown.edu Email : [email protected]
Challenges & Opportunities
Major Challenges:
Diverse set of policies and regulations across
participating institutions
Lack of resources (human and IT)
Multiple clinical & research information silo’es
Significant Opportunities/Strengths:
Technology development
Community engagement
Test bed for innovation
‘omics’ methods & integration
Collaborations with CTSA