Lymphatic system

Anatomy mathematics

•Cancer = bad cells = Bad inter cellular junctions

= cells slip away

Slipping away cells = A PROBLEM.Clearing process = Lymphatics

= Veins

Anatomy mathematics

•Lymphatic capillaries = Blind end

•= endothelium

• + overlapping junctions

• + vesicular system

•+ anchoring filaments

•+ Valves

Anatomy mathematics

•Lymph node = Fibrous skeleton(Capsule+

trabiculae)

• + Reticular stroma Reticulocytes+Rfibers

+

Lymphoid tissue

+ Sinuses subcapsular,trabicular and medullary

Direction of lymph flow through a

lymph node

Afferent lymphatic vessel

Subcapsular sinus

Trabecular or perinodular sinus

Medullary sinus

Efferent lymphatic vessel

Thoracic duct

Left subclavian vein

General circulationRoss and Pawlina, p. 419

capsu

lecap

sule

sub

capsu

lar sinu

s

sub

capsu

lar sinu

s

cortexcortex deep cortexdeep cortexmedullamedulla

hilus hilus (w/ artery and vein)(w/ artery and vein)

medullarymedullarysinussinus

medullarymedullarycordcord

Anatomy mathematics

•Lymphoid follicle = germinal center + Outer lymphocytes

capsulecapsule

sub

capsu

lar sinu

s

sub

capsu

lar sinu

s

cortexcortex

reticular cellreticular cell

endothelial cellsendothelial cells(easiest to see lining the inner wall, (easiest to see lining the inner wall, but they line the capsule as well)but they line the capsule as well)

Anatomy mathematics

•Lymphoid follicle = Lymphoid nodule

germinalgerminalcentercenter

lymphoblastslymphoblasts

medullarymedullarycordcord

medullarymedullarysinussinus

macrophagemacrophage

reticular cellreticular cell

lymphocyteslymphocytes

medullarymedullarysinussinus

medullarymedullarycordcord medullarymedullary

sinussinustr

abec

ula

trab

ecul

a

(con

nect

ive

tissu

e)

(con

nect

ive

tissu

e)

high endothelial venuleshigh endothelial venules

red pulpred pulp

centralcentralarteryartery

PALSPALS

Splenic red pulp

•Some anatomy mathematics

•Red pulp = sinusoids + splenic cords

•Splenic cords = billroth columns

Splenic cords and sinuses

Ross and Pawlina, p. 427

Splenic Circulation

Splenic artery Splenic vein

PALS: Periarterial (periarteriolar) lymphatic sheath

capsulecapsule

red pulpred pulp

white pulpwhite pulp

trabeculatrabecula(connective tissue)(connective tissue)

lumen of cryptlumen of crypt

stratified squamous epithelium

stratified squamous epithelium

secondary folliclessecondary folliclesw/ germinal centersw/ germinal centers

cortexcortex

medullamedulla

cortexcortex(immature T lymphocytes)(immature T lymphocytes)

medullamedulla(mature T lymphocytes)(mature T lymphocytes)thymic (Hassal’s)thymic (Hassal’s)

corpusclescorpuscles