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Webinar: Making Trials Work Harder 2 December 2015 at 12:00 Click the link to play the recording
Webinar: Making Trials Work Harder
2 December 2015 at 12:00
Click the link to play the recording
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Meeting Information:
Chaired by Jo Rick and Peter Bower
Presentation followed by a discussion session
Technical Issues:
If you are experiencing technical issues during this session, please contact the host (“HTMR-CTSU”) by sending a chat message
Please note this webinar will be recorded
Webinar: Making Trials Work Harder
2 December 2015 at 12:00
How do we make the gains outweigh the
pain?
*
*
Part 1:
*What are embedded methodology trials & why do we need them?
*‘Here’s one we made earlier …’ Examples from York CTU and the Healthlines studies
Questions?
Part 2:
*What have we learnt about doing embedded methodology trials? – our experiences, findings from the SWANS study
*What support and resources are out there?
Questions and discussion
*
*Testing RCT methodology
*One aspect of an RCT manipulated to test the impact of on
trial performance
*Examples include:
*Randomising participants to different methods of recruitment
*Randomising trial participants to different processes such as ways
of participating, format of reminders, use of incentives
*
Aims:
*Usually to improve trial recruitment and/or retention
*Other aims include:
*Widening participation
*Accessing hard to reach groups
* Improving informed quality of consent
*
Actual recruitment Target recruitment
*
*Trial recruitment can be
challenging
*Trials can fail to meet
recruitment targets for all
kinds of reasons
*Very little evidence about
effective recruitment
strategies in general…
*… 45 recruitment trials
identified
*
*Retention can be equally
challenging…
*…and suffers from the
same lack of evidence
about effective methods
as recruitment –
currently 38 retention
trials
*
*Healthlines - two linked trials of telehealth in depression
(Healthlines Depression) or cardiovascular risk (Healthlines CVD).
*The standard PIS optimised (see handout)
* Improved readability
* Improved navigation
*Participants randomised to receive either the standard or the
optimised PIS
*
*Depression: 6.3 % (optimised) randomised, 4.0 % (standard)
*4% recruitment = 15,000 invitations to recruit 600 6% recruitment = 10,000 invitations to recruit 600
*CVD: – no effect
*
*
Moving from
*‘Cottage industry’
*Individual studies
*One off interventions
Moving to
*Beyond individual studies
*Standardised interventions
*Repeated tests across
multiple trials
*
To get involved in the discussion:
• Either, if you have an audio connection
• Activate the Participants panel by
clicking here
• Alert the chair by clicking the
‘raise hand’ icon
• If you are selected, the chair will
unmute your microphone and
invite you to ask your question.
• Or, if you do not have an audio
connection
• Please type a brief text in the
Chat panel
• Select ‘Host & Presenter’ from the
‘Send to’ drop-down menu
• If your discussion/question is
selected, the chair will read it out
on your behalf.
*
*Embedded trial methodology:
* It is feasible (10 trials complete or in progress for
START)
*A number of barriers to implementing embedded
trial methodology
*SWANS is a Hub funded exploration of the
barriers and facilitators to the wider adoption
of embedded trials as a way of promoting
evidence based trials
Trial development
*
*Barriers & facilitators to embedded trials
Ideas to test
Peer review & ethics
* Ideas to
test
“What is it worth testing?”
“Where should efforts be
concentrated?”
“We need co-ordination?”
*
*
*
*TrialForge IQuaD initiative
*Retention intervention
*Promising results from one study
*No/low cost
*
*Potential motivators
*Skill development
*Publications
*Lead authorship
*Any others…?
*
To get involved in the discussion:
• Either, if you have an audio connection
• Activate the Participants panel by
clicking here
• Alert the chair by clicking the
‘raise hand’ icon
• If you are selected, the chair will
unmute your microphone and
invite you to ask your question.
• Or, if you do not have an audio
connection
• Please type a brief text in the
Chat panel
• Select ‘Host & Presenter’ from the
‘Send to’ drop-down menu
• If your discussion/question is
selected, the chair will read it out
on your behalf.
*
*Thinking about a trial you work on, what would be your
concerns about running an embedded methodology trial?
*What resources or types of support would help?
*why that type of support?;
*how should it be delivered?;
*by whom?/At what stage?
*
*http://www.qub.ac.uk/sites/TheNorthernIrelandNetworkfor
TrialsMethodologyResearch/SWATSWARInformation/Repositor
ies/SWATStore/www.trialforge.org
*www.trialforge.org
*
To get involved in the discussion:
• Either, if you have an audio connection
• Activate the Participants panel by
clicking here
• Alert the chair by clicking the
‘raise hand’ icon
• If you are selected, the chair will
unmute your microphone and
invite you to ask your question.
• Or, if you do not have an audio
connection
• Please type a brief text in the
Chat panel
• Select ‘Host & Presenter’ from the
‘Send to’ drop-down menu
• If your discussion/question is
selected, the chair will read it out
on your behalf.
*
*Thinking about a trial you work on, what would be your
concerns about running an embedded methodology trial?
*What resources or types of support would help?
*why that type of support?;
*how should it be delivered?;
*by whom?/At what stage?
