March 19, 2007

Center for Faculty Development and DiversityOffice for Postdoctoral Careers

Postdoctoral Research Fellow LuncheonBarbara E. Bierer, M.D.

Senior Vice President, Research, BWH

Director, Office for Postdoctoral Careers (OPC)

Director, Center for Faculty Development & Diversity

Caroline Rotondi

Administrative Director

Office for Postdoctoral Careers (OPC)

Center for Faculty Development & Diversity

Center for Faculty Development and DiversityOffice for Postdoctoral Careers

OPC Homepage – Recent Updates:

http://bwhbri.partners.org/bwh-opc/home.asp

Resource Center for Career & Professional Development information:

- Knowledge- Best Practices- Ideas- Advice- Helpful Links- Resources

Email your content suggestions to BWHPostdocCareers@partners.org

Center for Faculty Development and DiversityOffice for Postdoctoral Careers

Email your content suggestions to BWHPostdocCareers@partners.org

Postdoc Life @ BWH:

Center for Faculty Development and DiversityOffice for Postdoctoral Careers

Email your content suggestions to BWHPostdocCareers@partners.org

Orientation:

Center for Faculty Development and DiversityOffice for Postdoctoral Careers

Email your content suggestions to BWHPostdocCareers@partners.org

International Center:

Center for Faculty Development and DiversityOffice for Postdoctoral Careers

Email your content suggestions to BWHPostdocCareers@partners.org

Lab Management:

Center for Faculty Development and DiversityOffice for Postdoctoral Careers

Email your content suggestions to BWHPostdocCareers@partners.org

Science & Resources:

Center for Faculty Development and DiversityOffice for Postdoctoral Careers

Upcoming Events:

Registration NOT required

Center for Faculty Development and DiversityOffice for Postdoctoral Careers

4/23 Promotions on the Research TrackJaya Kumar, Program Director, HMS Office for Faculty Affairs

5/24 Mentoring and Individual Development PlansOrfeu Buxton, Instructor, Division of Sleep Medicine, BWH*4:30pm – 6:00pm

BWH Postdoctoral Research Fellow

LuncheonsCarrie Hall Conference Room

12:30pm – 2:00pm*

See BWH Event Calendar for details and registration

Center for Faculty Development and DiversityOffice for Postdoctoral Careers

4/5 Effective PresentationsThomas Lee, M.D., Network President, Partners Healthcare System

4/27 Grant Writing WorkshopVarious Faculty

4/30 Effective NegotiationsLinda Wilcox, HMS Ombudsperson

5/9 How to Get Your Paper PublishedCaren Solomon, M.D., Associate Professor of Medicine, BWH

6/11 Writers WorkshopJaylyn Olivo and Paul Guttry, BWH Editorial Service

Career & Professional Development Events

See BWH Event Calendar for details and registration

Imaging Program Seminar Series

Wednesday, April 4, 20074:00 - 5:30pm

Bornstein Amphitheater

Nathan McDannold, Ph.D.Assistant Professor of Radiology

MRI-guided Focused Ultrasound: A Noninvasive Method for Thermal Ablation and Targeted Drug Delivery

Ron Kikinis, M.D.Director, Surgical Planning Laboratory

Professor of RadiologyComputerized Image Analysis

Please register by sending an email to BWHBRI@partners.org

A networking reception will follow in Cabot Atrium. CME Credits are available for this seminar.

Brigham Research Community Monthly Forum

April 9, 200712:00-2:00PM

Carrie Hall Conference Room

Animal Space DiscussionMore to follow…

Please register at: http://www.brighamandwomens.org/view/EventDetails.aspx?eventID=36809

Center for Faculty Development and DiversityOffice for Postdoctoral Careers

HMS “ RED BOOK” INVITATIONAL RESEARCH FELLOWSHIP & GRANT OPPORTUNITIES

CALL FOR NOMINATIONS !!!

DUE APRIL 9, 2007

Postdoctoral and Faculty Fellowships/Grants available to HMS include:

Burroughs Wellcome Awards, Culpeper Scholarships, Medical Foundation Smith Family New Investigator Awards, Pew Scholars Program, Searle Scholars Program …and many more!!!

If you think you are an appropriate candidate for any of the awards listed on the website, please contact your division or department head.

Please direct all inquiries to: Office of Academic and Clinical Programs

Stacy A. McGrath, 617/432-3667, stacy_mcgrath@hms.harvard.edu orErin Cromack, 617/432-3633, erin_cromack@hms.harvard.edu

http://medapps.med.harvard.edu/fellowships

Center for Faculty Development and DiversityOffice for Postdoctoral Careers

BWH Event Calendar: http://www.brighamandwomens.org Health Information

Classes and Programs

List Events

Center for Faculty Development and DiversityOffice for Postdoctoral Careers

Professional Pathways Program

“What is Technology Transfer and isit a Potential Career Path for You?”

Brian N. Hicks, Director, Nicole D. Chiravuri, Ph.D., Licensing Associate,

BWH Corporate Sponsored Research & Licensing

The BWH Corporate Sponsored Research and Licensing (CSRL) business unit of Research Ventures and Licensing, presents:

-a summary of academic Technology Transfer and potential career paths

-skills and abilities required for scientists professionally interested in Tech Transfer

-day to day aspects of working in the Tech Transfer field.

• Research Ventures and Licensing •

Brian N. Hicks, Director

Nicole D. Chiravuri, Ph.D., Licensing Associate

Corporate Sponsored Research and Licensing

Brigham and Women’s Hospital

Presentation to: Office for Postdoctoral Careers

March 19, 2007

Agenda

• Technology Transfer Overview

• Licensing Associate Profile

• Discussion

PHS HealthCare Business: Research Profile

• Largest academic biomedical facility in the world

• ~1,900 Principal Investigators (MDs, PhDs, MDs/PhDs)*

* >5,000 total scientists involved in medical research

Principal Investigators as of March ‘06• MGH 975

• BWH 762

• McLean 132

• Spaulding 15

• Total 1,884

PHS Research Enterprise: NIH Research Funding

• Since 1994, PHS Hospitals are the largest (MGH) and second largest (BWH) non-university recipients of NIH research funding

• 2005* ranking among independent hospitals – FIRST - MGH

• $287 million• 694 awards

– SECOND - BWH• $253 million• 566 awards

* Most current available data from NIH

Technology Transfer Overview

•What is it? •How does it get transferred?•Who owns the technology?•Who gets the money?•What about funding for research?

What is Technology Transfer?

•Transfer of technological innovation from one party to another for purpose of developing and commercializing useful products

– From academia to industry: benefits and challenges for both — and for the investigator/inventor

What Technology is Transferred?

•Intellectual Property

– Inventions (usually patentable) • New, useful, not obvious

• Determined by patent lawyers, patent office, courts

– Copyrightable works - (mainly software)– Trademarks; trade secrets

•Tangible Research Property - (unpatentable biological materials)

•Intangible Research Property – (research results, know-how)

More On Patents

•Legal right to exclude others

•To preserve patentability: disclose to technology transfer office before public disclosure (oral presentations, publication) because foreign patent protection may be jeopardized (US: one-year grace period; ROW: must be first to file).

•Loss of foreign patent rights can greatly impact the financial value of an invention

Who Owns the Technology and Why?

• Intellectual Property, TRP: the hospitalsUnless: unrelated, no hospital resources, or made under approved consulting arrangement (and no hospital resources)

•Why?- Federal law: Bayh-Dole Act of 1980 permitting

universities/hospitals to elect ownership of inventions made under federal funding

- Obligated to have a written policy with its employees requiring disclosure and assignment of inventions and in return must share with the inventor(s) a portion of any revenue received from licensing the invention. 

- Institutional policy: Intellectual Property Policy

How is Technology Transferred?

•Informally

•Formally- agreements– Licenses, material transfer agreements,

confidentiality agreements, research agreements– Negotiated by technology transfer offices– Signed by authorized institutional representative-

investigators not authorized

PHS Technology Portfolio

FY03 FY04 FY05 FY06

Invention disclosures received

132 146 164 277

US patent filings 145 151 153 172

• PHS currently has ~900 technologies available for licensing, and our portfolio is grows annually

Research Ventures and Licensing (RVL)

65

131

172182 179

76 8091

108 104

4 7 4 8 11

0

20

40

60

80

100

120

140

160

180

200

FY02 FY03 FY04 FY05 FY06

Nu

mb

er

of

Ag

ree

me

nts

Fiscal Year

Sponsored Research Agreements

Licenses and Options

Annual Licenses & Options / Sponsored Research Agreements / Start-Ups

Start-Ups

PHS Technology Portfolio

Selected PHS Licensed Products

Embrel Hs CRP diagnostic

Licensed to

Pepcid Complete

FY06 Licensing Income: $328M

FY06 Royalty Income: $69M

Who Gets The Money?*

Inventor(s) (25%):Divided equally among all co-inventors

Inventor’s Lab

(25%)

BWH

(25%)

Inventor’s Department

(25%)

*After deducting unreimbursed patent/legal/marketing expenses

What About Funding For Research?

•Industry sponsored research– Part of license package, or separate– Academic rights (publication, collaboration, no

secrecy of research results) preserved– Intellectual property rights narrowly defined– Commingling with government funds OK

– FY06 PHS Corporate Sponsored Research Expenditures: >$75MM

Technology Transfer as a Career Path

•What is this profession all about?•Where do these professionals work?•What skills do I need?•What do technology transfer professionals do? •What are some resources?•Where do I start?

Where is the Technology Transfer Office?(and what do they do?)

There are technology transfer offices at universities, medical schools, hospitals, government agencies and in industry. Most offices provide technology transfer, research support, licensing and start-up activities.

Not all technology transfer offices are called the same name or do all the same things!

•Intellectual Property Office•Licensing Office•Some are part of a university’s Research Foundation•OTL, TLO, TVO, OTTL, TCO, OTD•Corporate Sponsored Research and Licensing (CSRL)

CSRL is part of Research Ventures and Licensing (RVL)

RVL Mission: To support innovative research and the broad translation of Partners HealthCare science to the patient bedside

Technology Transfer at Partners HealthCare

CSRL

Bus.Dev.

CIV

CSCR

• CSRL (Corporate Sponsored Research and Licensing)

– Provides technology transfer, research support, and licensing and start-up activities across MGH,

BWH, and other Partners institutions

• BD (Business Development)

– Markets intellectual property and establishes system-wide strategic alliances with the life sciences

industries to leverage Partners’ science base

• CIV (Center for Innovative Ventures)

– Promotes a culture of entrepreneurship by educating PHS faculty and supporting the creation and

financing of start-up ventures that result from inventions in PHS laboratories

• CSCR (Corporate Sponsored Clinical Research)

– Negotiates agreements and budgets for industry-sponsored clinical research across PHS

Research Ventures and Licensing (RVL)

Research Ventures and Licensing (RVL) Overview

What is a Technology Transfer Professional?

Someone who assists in the transfer of technological innovation(s) from one party to another for purposes of developing and commercializing useful products.

Different titles depending upon the office:

•Case Manager•Licensing Manager/Associate•Business Development Manager•Intellectual Property Manager/Associate•Industry Agreement Specialist/Associate

Who are Technology Transfer Professionals?

We come from a variety of backgrounds (some in combination):

•Science - Ph.D., M.S., B.S.•Business – M.B.A., Marketing•Law – J.D., patent agent

Technology Transfer as a Career Path

A Variety of Skills are Needed from:

•Science•Law•Business

•Such as: People SkillsNegotiating skills Decision-making skillsMulti-tasking skills Delegation skillsWriting skills Communication SkillsManagement Skills Evaluation Skills

Technology Transfer as a Career Path

A Mix of Daily Activities related to:

•Science•Law •Business

• Such as:Negotiating License Term Sheets and License AgreementsReviewing Invention Disclosures and Filing PatentsDrafting and Negotiating Agreements (Research, Material Transfer, Confidentiality, Consulting, Interinstitutional, Other)Managing Investigator Portfolios and Existing Licenses Evaluating Potential Start Up OpportunitiesInterface with OGC, Research Administration, VPs

PHS CSRL Agreements in FY 2006

MTA (675)

Consulting(696)

CDA(302)

License/Options(179)

SRAs (104)

Gifts/Other Agreements (72) IIA (36)

FY2006 Executed Agreements

(Total =1794)

Learn More about Technology Transfer

Association of University Technology Managers (AUTM)http://www.autm.net/index.cfm• Bayh-Dole Act• Public Benefits of Tech Transfer• Licensing Surveys• Issues in Technology Transfer• Look for a Job

Massachusetts Association of Technology Transfer Offices (MATTO)http://www.masstechtransfer.org/index.php• Local Events• Local Members• Look for a Job

The Job Hunt

•No experience in technology transfer? •Translate your Ph.D., post-doc, lab life into work

experience by highlighting your skills•Do an internship (usually unpaid)•Go on informational interviews•Go to local events and meetings•Create a network

CSRL: A Day in the Tech Transfer Life . . .

Y4

YEAR 1

Y0

YEAR 2 YEAR 3

CM Do Good

Dr. Inventor

• Invention Disclosure

Form

• Review• Assignment• POA• Declaration

Contact LicCo• Technical Summary• CDAs

Negotiate License Option

Manage LicCo Relationship

Review

PATENTFILING PROSECUTION ISSUANCE

Identify LicCo

• Start-up?• VC?

Additional Information

In case you’re interested:

RVL Website http://www.partners.org/rvl

BWH CSRL Website http://csrl.bwh.harvard.edu

Intellectual Property Policy for Partners-Affiliated Hospitals and Institutions http://intranet.partners.org/OGC/IPPolicy/IP_Index.html

Questions?

Thank you