NANOTECHNOLOGY INFOOD SUPPLEMENTS AND COSMETICS

Prof. Margareta Balabanova-Stefanova MD, PhD,Clinic of Dermatology, Medical Faculty in Skopje

University “St’s Cyril and Methodius” - Skopje, R. Macedonia

3-5 November 2011, Skopje, R. Macedonia

Nanotechnology is the creation of functional materials, devices and systems through control of matter on the nanometer length scale, and exploitation of novel phenomena and properties (physical, chemical, biological, mechanical, electrical...) at that length scale. In the area of cosmetics and anti-aging, in particular, as well as in the pharmaceutical arena, nanotechnology has played an important role in delivering active ingredients to the skin, in both patch delivery and timed release application.

Recent Pat Drug Deliv Formul. 2007;1(2):171-82. Nanotechnology: a new paradigm in cosmeceuticals. Kaur IP, Agrawal R. SourceDepartment of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. indupalkaur@yahoo.com

[PubMed - indexed for MEDLINE]

Nanoparticles/nanospheres, nanospheres sounds like futuristic technology.The revolution they triggered is apparent from the fact that cosmetics are no longer visualized as products that cover up or camouflage imperfections in personal appearance. The latest trend in these products is to combine clinically proven ingredients with patented delivery systems and the aesthetics of fine cosmetics. Cosmeceutical products are those poised on the gap between cosmetic products that simply cleanse and beautify and pharmaceuticals that cure and heal. According to The Freedonia Group Inc. Cleveland Ohio, the demand for formulated appearance-enhancing products is projected to increase by more than 12% per year up to 2007 to reach $2.5bn, making cosmeceuticals one of the most dynamic sectors within the cosmetics and personal care markets. Cosmetic industries rank high among the nanotechnology patent holders in U.S.; L'Oreal which devotes about $600 million of its annual $17 billion revenues to research is the industry leader on nanopatents. This report directly addresses the science behind the use of nanotechnology for the development of cosmetics.

Recent Pat Drug Deliv Formul. 2007;1(2):171-82. Nanotechnology: a new paradigm in cosmeceuticals. Kaur IP, Agrawal R. SourceDepartment of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. indupalkaur@yahoo.com

[PubMed - indexed for MEDLINE]

Nanotechnologies are hailed by many as the next industrial revolution.

They promise to change everything from the cars we drive to the clothes we wear, from the medical treatments our doctors can offer to our energy sources and workplace. Although focused on the very small, nanotechnologies offer tremendous potential benefits. From new cancer therapies to pollution-eating compounds, from more durable consumer products to detectors for biohazards like anthrax, from novel foods to more efficient solar cells, nanotechnologies are changing the way people think about the future.

http://www.mknano.com/?gclid=CInNifKDk6wCFQJO3godRh8-oghttp://www.nanotechproject.org/ http://penmedia.org/video/maynard.html The Twinkie Guide to Nanotechnology New Video Uses Snack Food to Help Unlock Mysteries of Nanotech Andrew Maynard WASHINGTON- The Twinkie Guide to Nanotechnology is an entertaining new video featuring scientist Andrew Maynard which mixes the iconic American snack cake with humor to unlock the mysteries of nanotechnology.

Products and Applications of Nanotechnology

Nanotechnology today is growing very rapidly and has infinite applications in almost everything we do.

The medicine we take, food we eat, chemicals we use, car we drive and much much more.

Nanotechnology is the art and science of manipulating matter at the nanoscale (down to 1/100,000 the width of a human hair) to create new and unique materials and products.

Nanotechnology has enormous potential to change society. An estimated global research and development investment of nearly $9 billion per year is anticipated to lead to new medical treatments and tools; more efficient energy production, storage and transmission; better access to clean water; more effective pollution reduction and prevention; and stronger, lighter materials. And these are just a few of the more significant ways in which people are discussing using the technology.

Nanotechnology 101 http://www.nanotechproject.org/

SUPPLEMENTS

Dairy products, cereals, breads and beverages are now fortified with vitamins, minerals such as iron, magnesium or zinc,

probiotics, bioactive peptides,antioxidants, plant sterols and soy. Some of these active ingredients are now being added to foods as nanoparticles or particles a few hundred

nanometres in size.

http://newhope360.com/retailing/should-natural-retailers-stock-functional-foods-immunity

SUPPLEMENTS

•

Omega 3-6-9Hemp ProductsCondition specificAyrveda

ALLNutritional BarsGreen TeaCoenzyme

Q10

Astaxanthin

UbiquinolNattokinaseGreen FormulasCoconut OilAntioxidants

Super FoodsNADHGlucosamineCLAAmino Acids

SAM-eMushroomsGinsengCarnitine, AcetylAlpha Lipoic

ResveratrolMulti -VitaminsFolic AcidCarnitineAlgae Products

Red Yeast RiceMineralsFish OilCalciumAHCC

ProteinMeal ReplacementFiberC VitaminsAcidophilus

ProbioticsJuicesEnzymesBone FormulasAcai

Phase 2HomeopathyE VitaminsBee Products7-Keto

PGXHerbsD VitaminsB Vitamins5-HTP

Supplements containing vitamins or dietary minerals are included as a category of food in the Codex Alimentarius, a collection of internationally recognized standards, codes of practice, guidelines and other recommendations relating to foods, food production and food safety. These texts are drawn up by the Codex Alimentarius Commission, an organization that is sponsored by the Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO).

http://en.wikipedia.org/wiki/Main_Page

A dietary supplement, also known as food supplement or nutritional supplement, is a preparation intended to supplement the diet and provide nutrients, such as vitamins, minerals, fiber, fatty acids, or amino acids, that may be missing or may not be consumed in sufficient quantities in a person's diet.

Some countries define dietary supplements as foods, while in others they are defined as drugs or natural health products.

http://en.wikipedia.org/wiki/Main_Page

http://newhope360.com/produce/super nutrients-food-better-supplements

Shopping for natural products online - It is important to ask yourself a few questions to make sure you are making a good decision and

getting great value:

1. Are products kept in a very clean, climate-controlled facility?

2. Can I see product expiration dates—so I know they won’t expire soon?

3. Is the company solid and reliable—not just outsourcing?

4. Will I find a large selection of top brands, in stock?

5. Will the shipping policy be reasonable and fair?

6. Is ordering and re-ordering fast, easy and, most importantly, SECURE?

7. Can I be sure my personal information is not at risk?

8. Is the company “green,” — environmentally friendly.

Cosmetics, Cosmeceuticals,Bath & Beauty

http://www.bolandcell.co.za/mycells.html

In the area of cosmetics and anti-aging, in particular, as well as in the pharmaceutical arena, nanotechnology has played an important role in delivering active ingredients to the skin, in both patch delivery and timed release application. Nanoparticles/nanospheres, nanospheres sounds like futuristic technology.

http://www.my-cells.net/

Nanotechnology: a new paradigm in cosmeceuticals.Kaur IP, Agrawal R. Recent Pat Drug Deliv Formul. 2007;1(2):171-82.

Source

Department of Pharmaceutics, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India. indupalkaur@yahoo.com

Cosmeceuticals, Nanotechnology, Primers = The New Terms of Skin Care Products

Cosmetic products have come a long way since the first cold cream was created. Galen’s (from second century Greece) cold cream was based on beeswax and water, also containing olive oil and rose petals for softness and scent. Back then there was only one product and no one was the wiser about skin types or ingredients for those specific skin types. Today, with so many advancements in ingredients, technology and delivery methods, it gets a little bit confusing and it’s enough to send us running from the beauty counter.

So here are some terms (with definitions) that you may come across while at the beauty counter:

http://www.kunstkennis.com/cosmeceuticals-nanotechnology-primers-the-new-terms-of-skin-care-products.html

Health and Beauty

Cosmeceuticals, Nanotechnology, Primers = The New Terms of Skin Care Products

Definitions (terms)

CosmeceuticalA term used to describe products that claim to have therapeutic affects. Health Canada and the FDA do not recognize this term as – in order for a product to have a therapeutic affect then it would be classified as a drug and would have to be approved as a drug. For the moment skin care products sold at the counter are classified as cosmetic products. The word came about with the marriage of the words cosmetic and pharmaceutical.

SerumSerums have a more watery consistency. Serums usually denote a product that is concentrated and has a high percentage of ingredients.

PrimerA term use to describe a cosmetic product that is used to prep or prime the skin for the next step. Generally a primer is a silicone based product that is applied to the face prior to foundation. It is said to fill in lines and wrinkles to provide a smooth finish for the foundation.

http://www.kunstkennis.com/cosmeceuticals-nanotechnology-primers-the-new-terms-of-skin-care-products.html

Definitions (terms)

Nanotechnology

A delivery method for ingredients. Ingredients are said to be reduced to a nano size format (usually 1/1000 the diameter of a human hair).

The idea behind nanotechnology is that the smaller the particle the better the product can be absorbed by the skin and get to the lower levels of the skin where it is needed and can provide benefits.

See more terms in our new glossary section. http://BeautyConnexion.com

Article Source: http://EzineArticles.com/?expert=Roula_Panagiotopoulos

http://www.kunstkennis.com/cosmeceuticals-nanotechnology-primers-the-new-terms-of-skin-care-products.html

Cosmetics, Cosmeceuticals, Bath & Beauty

…………………ToothpasteSkin CareFormulas, Beauty

Conditioner

…………………SunscreenShampooFormulas, AcneBubble bath

…………………SunblockMoutwashFacial CareBody Wash

…………………Soaps, LiquidHair ColoringDeodorantBath Salts & Soaks

Beauty BrandsSoaps, BarFormulas, Psoriasis

Cosmetics, Makeup

Aromatherapy

Skin and Transdermal Delivery System

Administration of a drug by diffusion through the skin into plasma, by means of a “patch” on the skin; supplies a fixed amount of the drug per unit time to the skin and bypasses the first-pass metabolic effect; examples include organic nitratesfor angina pectoris, scopolamine for motion sickness, fentanyl for chronic pain, hormone replacement and nicotine patches; supply of transdermal drugs is not yet widespread because of practical problems.

Skin and Transdermal Delivery System

24

Local dermatological treatment with

dermatics /dermaceuticals

Percutaneous absorption / Transdermal Delivery System

Pharmacokinetic phases

1. Liberatio

2. Adsorptio

3. Absorptio

4. Permeatio

5. Resorptio

6. EliminatioPossible pathways of penetration of local terapeutics

through skin barrier

Skin and Transdermal Delivery System

Nanoparticles or ultrafine particles, are particles generally considered to be less than 100nm in size. These particles have been implicated in morbidity and other adverse reactions.

Due to their small size, these particles may translocate from the lung to remote sites such as the heart, liver, brain or other extrapulmonary organs after inhalation exposure. Additionally, it has been suggested that the translocation of these particles may be responsible for adverse effects from ultrafine particles.

Scientists at Procter & Gamble Co. have initiated studies to determine whether nanoparticles translocate to extrapulmonaryorgans after inhalation of particles in rats.

•THE USE OF FLUORESCENTLY LABELED NANOPARTICLES TO DETERMINE THE EFFECT OF PARTICLE SIZE ON TRANSLOCATION FROM THE LUNG. Carter1, J.M., Kennedy1, J.M., Oberdorster2, G., Clark3, E.D. 1The Procter & Gamble Co., Cincinnati, OH; 2University of Rochester, Rochester, NY; 3The Health and Environmental Safety Alliance, Cincinnati, OH. Presented at Society of Toxicology Annual Meeting, Baltimore, MD. March 21-25, (2004).

Briefly, Fisher 344 female rats were exposed via an aspiration model to fluorescently labeled polystyrene ranging in size from 20 nm to 400 nm. Animals were sacrificed 1, 3, 7 and 14 days after exposure to nanoparticles. Lung, heart, brain, spleen, kidney and liver tissues were removed and preserved for histological examination. Blood was also collected for examination of nanoparticles. Tissue was examined via confocal microscopy for presence of fluorescent nanoparticles.

In vitro experiments using EpiAirway tissue constructs were also performed to evaluate membrane/cell/particle interactions.Histological evaluations were performed on these tissues 2, 8, and 24 hours post exposure.

In vivo experiments indicate a correlation between size and the ability of these particles to migrate from the lung after inhalation exposure.

Additionally, (EpiAirway) in vitro data yielded similar findings indicating particle size is a factor in predicting translocation potential of nanosized particles.

Conclusion

1. Critical decisions affecting the development andcommercialization of nanotechnologies.

2. An active public and policy dialogue. It is not an advocate either for, or against, particular nanotechnologies. We seek to ensure that as these technologies are developed, potential human health and environmental risks are anticipated, properly understood, and effectively managed.

http://www.mknano.com/?gclid=CInNifKDk6wCFQJO3godRh8-oghttp://www.nanotechproject.org/

Conclusion

“Ex parvis saepe magnorum momenta

rerum pendent” (Livius): “Small things are often reason for big events”

“Abusus non tollit usum” “Abuse does not mean not to use”

C:\Documents and Settings\a\Desktop\Nano-Care

Deutschland AG Technology_files

Conclusion

Nobody is against THEORY,

except…PRACTICE! (*)

C:\Documents and Settings\a\Desktop\Nano-Care

Deutschland AG Technology_files

THANK YOU!

http://www.mknano.com/?gclid=CInNifKDk6wCFQJO3godRh8-og

Natural/Dermatological Miracle(Engineering)