M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 1 of 16
Study & Evaluation Scheme
of
Master of Pharmacy
(Pharmacology) [Applicable w.e.f. Academic Session 2011-12 till revised]
TEERTHANKER MAHAVEER UNIVERSITY N.H.-24, Delhi Road, Moradabad, Uttar Pradesh-244001
Website: www.tmu.ac.in
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 2 of 16
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DDeellhhii RRooaadd,, BBaaggaarrppuurr,, MMoorraaddaabbaadd ((UU..PP))
Study & Evaluation Scheme
of
MASTER OF PHARMACY SUMMARY
Programme : M. Pharm. (Pharmacology)
Duration : Two years full time
Medium : English
Minimum Required Attendance : 75 percent
Credits
Maximum credits : 95
Minimum credits required for the degree : 90
Assessment : Internal External Total
30 70 100
Internal Evaluation (Theory Papers) :
Class
Test
I
Class
Test
II
Class
Test
III
Continuous
Evaluation
Seminar Total
10 10 10 5 5 30
Duration of Examination :
Theory Practical
External Internal External Internal
3 hrs. 1.5 hrs. 4 hrs. 4 hrs.
To qualify the course a student is required to secure a minimum of 40% marks in aggregate in the end
semester examination and teachers continuous evaluation (i.e. both internal and external). A candidate who
secures less than of 40% of marks in a course shall be deemed to have failed in that course. The student
should have overall 50% marks in a semester to clear the semester. In case a student has more than 40% in
each course but less than 50% overall in a semester he/she shall re-appear in one or two course(s) to improve the percentage. There will be three Class Tests in a semester and an average of the marks obtained in best two
tests will be computed (cumulatively) for the final result.
The class tests would comprise of five questions. Student shall have to answer three questions out of which
one question will be compulsory. Each question would be of five marks.
Question Paper Structure:
1. The question paper shall consist of eight questions. Out of which first question shall be of short
answer type (not exceeding 50 words) and will be compulsory. Question No. 1 shall contain 8 parts
representing all units of the syllabus and students shall have to answer any five (weightage 4 marks
each).
2. Out of the remaining seven questions, a student shall be required to attempt any five questions.
There will be minimum one and maximum two questions from each unit of the syllabus. The
weightage of Question No. 2 to 8 shall be 10 marks each.
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 3 of 16
Study & Evaluation Scheme
Programme: M.Pharm. Semester I
S.N.
Course
Code
Subject Periods
C
Evaluation Scheme
L T P Internal External Total
1 MPA101 Modern Analytical
Techniques (MAT)
4 2 - 5 30 70 100
2 MPL101 Pharmaceutical Biostatistics
and Computer Applications
4 2 - 5 30 70 100
3 MPL102 Pharmacology – I
(Fundamentals of
Pharmacology)
4 2 - 5 30 70 100
4 MPA151 Modern Analytical
Techniques (MAT) Lab
- - 8 4 30 70 100
5 MPL152 Pharmacology (Fundamentals
of Pharmacology) Lab
- - 8 4 30 70 100
Total 12 6 16 23 150 350 500
Semester II
S.N.
Course
Code
Subject Periods Credits Evaluation Scheme
L T P Internal External Total
1 MPL201 Recent Advances in
Pharmacology
4 2 - 5 30 70 100
2 MPL202 Pharmacological Screening and
Toxicology
4 2 - 5 30 70 100
3 MPL203 Clinical Pharmacology 4 2 - 5 30 70 100
4 MPL251 Research Project Synopsis - 2 - 1 50 50 100
5 MPL252 Pharmacological Screening and
Toxicology Lab
- - 8 4 30 70 100
6 MPL253 Clinical Pharmacology Lab - - 8 4 30 70 100
Total 12 8 16 24 200 400 600
Semester III
S.N.
Course
Code
Subject Periods Credits Evaluation Scheme
L T P Internal External Total
1 MPL351 Research Project Phase -I - - 48 24 50 50 100
Total - 48 24 50 50 100
Semester IV
S.N.
Course
Code
Subject Periods Credits Evaluation Scheme
L T P Internal External Total
1 MPL451 Research Project Phase -II
(Thesis compilation and
Viva-Voce)
- - 48 24 50 50 100
Total - 48 24 50 50 100
Research Project shall be carried out in different stages. It will commence with submission and approval of
synopsis in second semester. The experimental work shall be carried out in two phases i.e. in III & IV
semesters.
Note: L – Lecture T- Tutorial P- Practical C- Credits
1L = 1Hr 1T= 1 Hr 1P=1 Hr 1C =1Hr of Theory paper
= 2Hrs of Practical
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 4 of 16
M. Pharm. Semester I
MODERN ANALYTICAL TECHNIQUES (MAT)
Course Code: MPA101 L-4, T-2, P-0, C-5 Objective: The basic objective of this course is to get familiar with Principle, theory & instrumentation of sophisticated pharmaceutical analysis instruments and the interpretation of their spectra.
Unit - 1
Principle, Theory & Instrumentation of UV-Visible spectroscopy. Its utility in structural qualitative and
quantitative analysis of drug molecules, woodward fischer rules and use of shiff’s reagents for
elucidation of structure. (8 Hours)
Unit – 2
Infrared spectroscopy, I.R radiation and its interaction with organic molecules, vibrational mode of
bonds, instrumentation and application, effect of hydrogen bonding and conjugation on absorption bands,
interpretation of IR Spectra, FTIR and ATR. (8 Hours)
Unit – 3
Nuclear magnetic resonance spectroscopy: chemical shift concept, isotopic nuclei, reference standards
and solvents. 1H NMR spectra, coupling constants, interpretation of spectra, decoupling-double
resonance and shift reagent methods.
Principles of FT-NMR with reference to 13C NMR, free induction decay. Spin-spin and spin-lattice
relaxation phenomenon. Nuclear overhauser enhanced 13C NMR spectra, their interpretation and
application. (8 Hours)
Unit – 4
Mass spectrometry: Basic principles and brief outline of instrumentation. Ion formation, molecular ion,
metastable ion, fragmentation process in relation to molecular structure and functional groups. Relative
abundance of isotopes, chemical ionization, GC-MS and LC/MS. Interpretation of spectra of simple
molecules. (8 Hours)
Unit – 5
Chromatographic techniques: Principles of separation and application of Column, Paper, Thin layer and
Gas chromatography, HPLC, HPTLC, Electrophoresis. Instrumentation of HPLC, Reverse phase
columns.
Pharmaceutical evaluation of drug in biological fluids- bioassays. Radioimmunoassay.
(8 Hours)
Recommended Books
1. Willard, H.H., Merrit, L.L., Dean, J.A., Settle, P.A., Instrumental Methods of Analysis, Van
Nostrand. 2. Skoog, D.A., Heller, F.J., Nieman, T.A., Principles of Instrumental Analysis, WB Saunders.
3. Haswell, S.J., ed. Atomic Absorption Spectroscopy, Elsevier.
4. Ardrey, R.E., Pharmaceutical Mass Spectra, Pharmaceutical Press, London.
5. Sethi, P.D., Quantitative Analysis of Pharmaceutical Formulations, CBS Publishers, New Delhi. 6. Kalsi, P.S., Spectroscopy of Organic Compounds, New Age Publishers, New Delhi.
7. Gross J.H., Mass Spectrometry, Springer Berlin, Heidelberg.
8. Haffmann D. H., Advances in Chromatography, Marcel Dekker.
9. Robert D. Braun, Introduction to Instrumental Analysis, McGraw-Hill.
10. Wilfried, M.A. Niessen- Liquid Chromatography-Mass Spectrometry, Marcel Dekker.
*Latest editions of all the suggested books are recommended. .
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 5 of 16
Semester I
PHARMACEUTICAL BIOSTATICS AND COMPUTER APPLICATIONS
Course Code: MPL101 L-4, T-2, P-0, C-5
Objective: The basic objective of this course is to get familiar with pharmaceutical biostatics and computer applications.
Unit - 1
Methods of collection of data, classifications and graphical representation of data. Binomial and
normal probability distribution. Polygon, histogram, measure of central tendency. Significance of
statistical methods, probability, degree of freedom, measures of variation - Standard deviation,
Standard error. (8 Hours)
Unit - 2
Sampling, sample size and power. Statistical inference and hypothesis. Tests for statistical
significance: student t-test, Chi-square test, confidence level, Null hypothesis. (8 Hours)
Unit - 3
Linear regression and correlation. Analysis of Variance (one way and two way). Factorial designs
(including fraction factorial design). Theory of probability, Permutation and Combination, Ratios, Percentage and Proportion. Two way ANOVA and Multiple comparison procedures. (8 Hours)
Unit - 4
Non-parametric tests, Experimental design in clinical trials, Statistical quality control, Validation, Optimization techniques and Screening design. Correlation and regression, least square method,
significance of coefficient of correlation, nonlinear regression. (8 Hours)
Unit - 5
Bioassays-calculations of doses response relationships, LD50, ED50.
Applications of software for statistical calculation viz. SPSS, foxtron. (8 Hours)
Book Recommended
1. Bolton, Pharmaceuticals Statistics- Practical & Clinical Applications, Marcel & Dekker, New
York.
2. Fisher, R.A., Statistical Methods for Research Works, Oliver & Boyd, Edinburgh.
3. 3. Chow, Statistical Design and Analysis of Stability Studies, Marcel Dekker, New York.
4. 4. Buncher, Statistics in the Pharmaceutical Industry, Marcel Dekker, New York.
5. 5. Finney, D.J., Statistical Methods in Biological Assays, Hafner, New York.
6. 6. Montgomery, D.C., Introduction to Statistical Quality Control, Willy.
7. 7. Lipschutz, Introduction to Probability and Statistics, McGraw-Hill.
8. 8. Li wan Po, Statistics for Pharmacist, Wiley-Blackwell.
* Latest editions of all the suggested books are recommended.
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 6 of 16
Semester I
PHARMACOLOGY – I (FUNDAMENTALS OF PHARMACOLOGY)
Course Code: MPL102 L-4, T-2, P-0, C-5
Objective: The basic objective of this course is to get familiar with Basic pharmacology.
Unit-1
Basic Principles of Pharmacology: Mechanisms of drug action, General aspects of receptor
pharmacology, Drug metabolism, Pharmacogenetics. (8 Hours)
Unit-2
Pharmacology of Autonomic & Somatic Nervous System: Autonomic & somatic nervous
systems, Muscarinic receptor agonists & antagonists, Anticholinesterases, Agents acting at
neuromuscular junction & autonomic ganglia,
Sympathomimetic drugs & adrenergic antagonists (8 Hours)
Unit-3
Pharmacology of Central Nervous System:Neurotransmission in CNS, Drugs used in the
treatment of:Anxiety & Psychosis, Depression & Mania, Epilepsy, CNS degenerative disorders, Parkinson’s disease (8 Hours)
Unit-4
Drugs affecting renal and cardiovascular function: Diuretics, Renin & Angiotensin System, Drugs used in the treatment of:Myocardial Ischemia Hypertension Congestive Heart Failure (CHF)
Hyperlipidemia
(8 Hours)
Unit-5 Drug addiction & drug abuse (8 Hours)
Books Recommended
1. Goodman & Gillman, The Pharmacological Basis of Therapeutics, Macmillan, ninth edition,
1995
2. Rang Dale & Ritter, Pharmacology, Churchill Livingstone, third edition, 1995.
3. Mutschler E., Deprendent H., Drug Actions: Basis Principles and Therapeutic Aspects: CRC
press 1995.
4. Katzung, Basis & Clinical Pharmacology, McGraw Hill Professional.
5. Craig C.R. & Stitzel R.E., Modern Pharmcology, Little, Brown.
6. Laurence D.R. & Benett P.N., Clinical Pharmcology, Churchill Livingstone.
7. Barar F.S.K., Essentials of Pharmcotherapeutics, S. Chand & Company Limited.
8. James Crosland, Lewis’s Pharmacology, Williams and Wilkins.
* Latest editions of all the suggested books are recommended.
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 7 of 16
Semester I
MODERN ANALYTICAL TECHNIQUES (MAT) LAB
Course Code: MPA151 L-0, T-0, P-8, C-4
Objective: The basic objective of this course is to get familiar with different analytical instruments.
Based on the Course Code: MPA101
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 8 of 16
SEMESTER I
PHARMACOLOGY – I
(FUNDAMENTALS OF PHARMACOLOGY) LAB
Course Code: MPL152 L-0, T-0, P-8, C-4
Objective: The basic objective of this course is to get familiar with pharmacology practicals.
Based on the Course Code: MPL102
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 9 of 16
Semester II
RECENT ADVANCES IN PHARMACOLOGY
Course Code: MPL201 L-4, T-2, P-0, C-5 Objective: The basic objective of this course is to get familiar with advanced pharmacology.
Unit-I
Autacoids:
Histamine, Serotonin, Bradykinin & their antagonists
Eicosanoids & PAF
Anti-inflammatory, analgesic & antipyretic agents
Anti-asthmatic agents (8 Hours)
Unit-II
Drugs affecting gastro intestinal function:
Agents for control of acidity and antiulcer drugs
Emetics & anti emetics. (8 Hours)
Unit-III
Principles of Chemotherapy:
Chemotherapeutic agents:
a. Fluroquinolones
b. Cephalosporin and other newer agents
c. Antifungal & antiviral drugs
d. Chemotherapy of Neoplastic diseases (8 Hours)
Unit-IV
Gene therapy:
a. General concept of gene therapy
b. Gene therapy for hereditary diseases, cancer & HIV
c. Antisense therapy (8 Hours)
Unit-V
Immunopharmacology: a. Immunosuppressive agents, Immunomodulators
b. Current concepts in pharmacotherapy of HIV
c. In vitro and in vivo tests for immunological investigation (8 Hours)
Books Recommended
1. Goodman & Gillman, The Pharmacological Basis of Therapeutics, MacMillan, 1995
2. Rang Dale & Ritter, Pharmacology, Churchill Livingstone, 1995.
3. Mutschler E., Deprendent H., Drug Actions: Basis Principles and Therapeutic Aspects: CRC press 1995.
4. Katzung, Basis & Clinical Pharmacology, McGraw Hill Professional.
5. Craig C.R. & Stitzel R.E., Modern Pharmacology, Little Brown.
6. Laurence D.R. & Benett P.N., Clinical Pharmacology, Churchill Livingstone.
7. Barar F.S.K., Essentials of Pharmcotherapeutics, S. Chand & Company Limited.
8. James Crossland, Lewis’s Pharmacology, Williams and Wilkins.
* Latest editions of all the suggested books are recommended
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 10 of 16
Semester - II
PHARMACOLOGICAL SCREENING & TOXICOLOGY
Course Code: MPL202 L-4, T-2, P-0, C-5
Objective: The basic objective of this course is to get familiar with pharmacological screening and
toxicology.
Unit-I
Drug discovery process: Principles, techniques & strategies used in new drug discovery
Principles of toxicity evaluations
High throughput screening
Regulations for laboratory animal care and ethical requirements (8 Hours)
Unit-II Pharmacological screening of new drugs belonging to following categories: Antipsychotic agents,
anti-anxiety agents, nootropic drugs, antidepressant drugs, anti-parkinsonian drugs, antiepileptic.
(8 Hours)
Unit-III
Pharmacological screening of new drugs belonging to following categories: Analgesics & anti-
inflammatory agents, antiulcer, antihypertensives, antiarrhythmic agents, antiatherosclerotic drugs,
antidiabetic, antifertility agents (8 Hours)
Unit-IV
Principles of toxicology:
Abnormal action of drugs; tolerance, addiction, habituation, idiosyncracy, allergy, hypersensitivity,
antagonism, synergism, potentiating, tachyphylaxis, teratogenicity & Mutagenicity. (8 Hours)
Unit-V
Heavy Metals Poisoning. (8 Hours)
Books Recommended
1. Turner R.I., Screening Methods in Pharmacology, Academic Press, 1965.
2. Laurance & Bacharch, Pharmacometrics, VOL. I & II, Academic Press.
3. Seth U.K., Dadkar Kamathy, Eperimental Topics in Pharmacology, Academic Press Inc.
4. Floyd R. Domer, Animal Experimental in Pharmacological Analysis. Thomas.
5. Ian Kitchen, In vitro Experiments in Pharmacology, Blackwell Scientific Publications, 1984.
6. Ghosh M.N., Fundamental of Experimental Pharmacology, Scientific Book Agency, 1984.
* Latest editions of all the suggested books are recommended.
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 11 of 16
Semester – II
CLINICAL PHARMACOLOGY
Course Code: MPL203 L-4, T-2, P-0, C-5
Objective: The basic objective of this course is to get familiar with clinical pharmacology.
Unit-I
Principles of Clinical Pharmacokinetics:
a. Dose -response in human
b. Influence of renal and hepatic disease on pharmacokinetics
c. Therapeutic drug monitoring (TDM)
d. Population pharmacokinetics; Racial, gender & ethnic differences in drugs response
(8 Hours)
Unit-II Clinical evaluation of drug: Evaluation of drug in human, terminologies, organization, types of clinical
research and phases of clinical evaluation of drug (8 Hours)
Unit-III
Adverse Drug Reactions (ADR) & Pharmacovigilance (8 Hours)
Unit-IV
Pharmacotherapy and management of the following disorders: a. Hepatic disorders: cirrhosis, hepatitis.
b. Renal diseases: Acute and chronic renal failure, renal dialysis and transplantation, drug doses
in renal impairment.
c. Respiratory diseases: asthma, chronic obstructive pulmonary edema, pulmonary embolism.
(8 Hours)
Unit-V
Pharmacotherapy and management of the following disorders: a. Endocrine disorders: diabetes, obesity.
Infectious diseases: tuberculosis, leprosy, urinary & gastrointestinal tract infections, fungal
and viral infection. General guidelines for rational use of antibiotics, resistance to antibiotics.
(8 Hours)
Books Recommended
1. Grahame – smith D.G. and Aronson J.K., Oxford Text Book of Clinical Pharmacology and Drug
Therapy, Oxford University.
2. Katzung, Basic and Clinical Pharmacology, McGraw Hill Professional, 1995 edition
3. Drug actions: Basic Principles and Therapeutic Aspects: Ernest Muscular Harmat Desendor Press,
1995
* Latest editions of all the suggested books are recommended
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 12 of 16
Semester –II
RESEARCH PROJECT SYNOPSIS
(SYNOPSIS SUBMISSION & EVALUATION) Course Code: MPL251 L- 0, T-2, P-0, C-1
Objective: The basic objective of this course is to get familiar with the method, instrumentation and the
technology of the topic that is selected for the dissertation.
Curriculum Details:
1. The course will comprise of preparation of synopsis for the proposed research work to be done
during third and fourth semester courses.
2. The allotted supervisor will provide guidelines and determine the topic of the research work
based on thorough literature reviews.
3. The final presentation will be evaluated by the supervisor(s) concerned for 25 marks .
4. A committee of senior faculty of the institute including supervisor(s), will finally evaluates the
quality of the proposed work and its relevance in the pharmaceutical field (out of 75 marks).
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 13 of 16
Semester - II
PHARMACOLOGICAL SCREENING & TOXICOLOGY LAB
Course Code: MPL252 L-0, T-0, P-8, C-4
Objective: The basic objective of this course is to get familiar with pharmacological screening and
toxicology practicals.
Based on the Course Code MPL202
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 14 of 16
Semester - II
CLINICAL PHARMACOLOGY LAB
Course Code: MPL253 L-0, T-0, P-8, C-4
Objective: The basic objective of this course is to get familiar with clinical pharmacology practicals.
Based on the Course Code MPL203
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 15 of 16
Semester III
RESEARCH PROJECT (PHASE-I)
(TO BE CONTINUED IN SEMESTER-IV) Course Code: MPL351 L- 0, T-0, P-48, C-24
Objective: The basic objective of this course is to represent the findings of the project that has been
done in the dissertation.
Guidelines:
1. The course will comprise of the confirmation of the proposed research work based on the initial
experimentation to confirm the feasibility of the work.
2. The allotted supervisor(s) will provide guidelines with exploration of the line of action with
recent trends of research in the related field and confirm global acceptability with regards to
industry and academic problems.
3. The continuous literature survey and modification of experimental pathway will be taken in to
practice with regular monitoring.
4. The candidate’s performance will be evaluated by the supervisor(s) and the internal committee of
at least three senior faculties in addition to the allotted supervisor(s). There will be atleast two
seminars to be presented before the committee in this semester consisting of the progress of the
research work.
5. Each seminar will be of 50 marks.
M. Pharm. (Pharmacology) Syllabus Applicable w.e.f. Academic Session 2011-12 (22022012) Page 16 of 16
Semester IV
RESEARCH PROJECT (PHASE –II)
(THESIS COMPILATION & VIVA-VOCE) Course Code: MPL451 L-0, T-0, P-48, C-24
Objective: The basic objective of this course is to present the findings of the project that has been
carried out in different phases.
Guidelines:
1. The progress of research work will be continuously evaluated by the supervisor(s) concerned.
2. There will be at least two presentations in this semester and each will be evaluated out of 25
marks by the internal committee of at least three senior faculties besides the allotted
supervisor(s).
3. The external examiner appointed by the university will finally evaluate the thesis by way of
viva- voce and presentation by the candidate out of the remaining 50 marks.