May 16 th - 18 th , 2019 Università degli Studi di Milano Milan, Italy www.translationalimmunology.it International Conference of translational medicine on pathogenesis and therapy of immunomediated diseases 5 th Innate immunity, inflammation and experimental models of human diseases PRELIMINARY SCIENTIFIC PROGRAM Viale G. Matteotti, 7 • 50121 Florence • Italy Ph. +39 055 50351 • www.oic.it • [email protected]OIC Srl is a MedTech Trusted Partner ORGANIZING SECRETARIAT CONFERENCE VENUE Università degli Studi di Milano Aula Magna Via Festa del Perdono, 7 • Milan SIICA SECRETARIAT Rita Repizzi Tel. +39 333 4398196 • [email protected]www.siica.org Follow us on FACEBOOK
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May 16th - 18th, 2019Università degli Studi di MilanoMilan, Italy
www.translationalimmunology.it
International Conference of translational medicineon pathogenesis and therapyof immunomediated diseases
5th
Innate immunity, inflammation and experimental models of human diseases
May 16th - 18th, 2019Università degli Studi di MilanoMilan, Italy
5 Innate immunity, inflammation and experimental models of human diseases
International Conference of translational medicineon pathogenesis and therapy of immunomediated diseases
th
3
th
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STEERING COMMITTEE Francesco Annunziato
Massimo LocatiDomenico Mavilio
SCIENTIFIC COMMITTEEFrancesco Annunziato
Flavia BazzoniEnnio Carbone
Marco CassatellaRaffaele De PalmaFrancesca Di RosaArmando Gabrielli
Francesca GranucciMassimo Locati
Enrico LugliDomenico Mavilio
Luis MontanerWilliam Nauseef
Luigi NotarangeloIsabella QuintiAngela Santoni
Antonio SicaAnna Villa
May 16th - 18th, 2019Università degli Studi di MilanoMilan, Italy
5 Innate immunity, inflammation and experimental models of human diseases
International Conference of translational medicineon pathogenesis and therapy of immunomediated diseases
th
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THURSDAY, 16th MAY 2019THURSDAY, 16th MAY 2019
15.00-15.30 OPENING CEREMONY - Welcome and opening remarks Massimo Locati, University of Milan and Humanitas Research Hospital, Milan, Italy Domenico Mavilio, University of Milan and Humanitas Research Hospital, Milan, Italy Angela Santoni, La Sapienza University, Rome, Italy
15.30-17.20 SESSION 1 - AUTOINFLAMMATION AND BEYOND Supported by Society of Leukocyte Biology & Journal of Leukocyte Biology Chairs: Ivona Aksientevich, National Institutes of Health, Bethesda, USA
William Nauseef, University of Iowa, Iowa City, USA
15.30-15.50 Updates on pathophysiology of autoinflammatory diseases Ivona Aksientevich, National Institutes of Health, Bethesda, USA
15.50-16.00 Phenotypical and functional characterization of innate immunity cells in
Adenosine deaminase 2 deficiency (DADA-2) Ferdinando Oriolo, National Institutes of Health, Bethesda, USA - University of Milan and Humanitas Research Hospital, Milan, Italy
16.00-16.20 New advance in the treatment of autoinflammatory diseases Marco Gattorno, Istituto Giannina Gaslini, Genoa, Italy
16.20-16.30 Cytokine secretion by blood leukocytes provides biotherapeutic options for patients suspected of chronic auto inflammatory syndromes
Martin Pelletier, CHU de Québec-Université Laval Research Center, Canada
16.30-16.50 Immunedysregulation and platelets: a new scenario in Wiskott Aldrich Anna Villa, CNR and San Raffaele Institute, Milan, Italy 16.50-17.00 Regulation of Treg plasticity by the environment and its relevance in human
autoimmune disease Margarita Dominguez Villar, New Haven, USA - Imperial College, London, United Kingdom
17.00-17.20 Discussion panel
17.20-17.50 Coffee break
May 16th - 18th, 2019Università degli Studi di MilanoMilan, Italy
5 Innate immunity, inflammation and experimental models of human diseases
International Conference of translational medicineon pathogenesis and therapy of immunomediated diseases
th
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THURSDAY, 16th MAY 2019
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17.50-19.10 SESSION 2 - NEW INSIGHTS IN HAEMATOPOIETIC STEM CELL TRANSPLANT Chairs: Marco A. Cassatella, University of Verona, Verona, Italy
Luca Castagna, Humanitas Research Hospital, Milan, Italy
17.50-18.10 TBD
18.10-18.30 CAR T cells and beyond - Clinics Franco Locatelli, Ospedale Bambin Gesù, Rome, Italy
18.30-18.50 HCMV and viral infection in HSCT (old and new approaches) Didier Blaise, Centre de Recherche en Cancèrologie de Marseille, Marseille, France
18.50-19.10 Discussion panel
19.15-20.00 OPENING KEYNOTE LECTURE Chair: Anna Villa, CNR and San Raffaele Institute, Milan, Italy
(Re)discovering primary immune deficiencies Luigi Notarangelo, National Institutes of Health, Bethesda, USA
20.00 Welcome cocktail for all delegates
May 16th - 18th, 2019Università degli Studi di MilanoMilan, Italy
5 Innate immunity, inflammation and experimental models of human diseases
International Conference of translational medicineon pathogenesis and therapy of immunomediated diseases
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FRIDAY, 17th MAY 2019
08.30-09.15 KEYNOTE LECTURE Chair: Luigi Notarangelo, National Institutes of Health, Bethesda, USA Toward a genetic theory of childhood infectious diseases
Jean-Laurent Casanova, Rockfeller University, New York, USA
09.20-11.10 SESSION 3 - IMMUNODEFICIENCIES Chairs: Luigi Notarangelo, National Institutes of Health, Bethesda, USA
Anna Villa, CNR and San Raffaele Institute, Milan, Italy
09.20-09.40 Title TBD Dan Kastner, National Institutes of Health, Bethesda, USA
09.40-09.50 Selected abstract
09.50-10.10 Human type I interferonopathies: insights into pathogenesis and therapy Yanick J. Crow, University of Edinburgh, Edinburgh, United Kingdom
10.10-10.20 Selected abstract
10.20-10.40 Anticytokine autoantibodies: what are they doing and what should we do about it? Steve Holland, National Institutes of Health, Bethesda, USA
10.40-10.50 Selected abstract
10.50-11.10 Discussion panel
11.10-11.30 Coffee break
11.30-13.00 SATELLITE SYMPOSIUM Sponsored by Becton Dickinson
Immunological therapies and monitoring: treatments and readout have never been more linked
13.00-13.30 Break
13.30-14.30 POSTER VIEW
May 16th - 18th, 2019Università degli Studi di MilanoMilan, Italy
5 Innate immunity, inflammation and experimental models of human diseases
International Conference of translational medicineon pathogenesis and therapy of immunomediated diseases
th
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FRIDAY, 17th MAY 2019
May 16th - 18th, 2019Università degli Studi di MilanoMilan, Italy
5 Innate immunity, inflammation and experimental models of human diseases
International Conference of translational medicineon pathogenesis and therapy of immunomediated diseases
th
7
14.30-16.20 SESSION 4 - AUTOIMMUNITY Chairs: Francesco Annunziato, University of Florence, Florence, Italy
14.30-14.50 Functional autoantibodiesin systemic sclerosis pathogenesis Armando Gabrielli, University of Ancona, Ancona, Italy
14.50-15.00 Selected abstract
15.00-15.20 Manipulating regulatory T cell pathways to restore immune tolerance Talal Chatila, Harward University, Boston, USA
15.20-15.30 Selected abstract
15.30-15.50 Functional adaptation of Foxp3+ regulatory T cells in inflammatory diseases Ciriaco A. Piccirillo, Montreal Diabetes Research Center, Montreal, Quebec, Canada
15.50-16.00 Selected abstract
16.00-16.20 Discussion panel
16.20-16.50 Coffee break
17.00-17.45 KEYNOTE LECTURE Chair: Angela Santoni, La Sapienza University, Rome, Italy Revisiting interleukin-2: biology and therapeutic advances
Abul Abbas, University of California, San Francisco, USA
20.00 Social dinner and award ceremony for the best abstracts
May 16th - 18th, 2019Università degli Studi di MilanoMilan, Italy
5 Innate immunity, inflammation and experimental models of human diseases
International Conference of translational medicineon pathogenesis and therapy of immunomediated diseases
th
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SATURDAY, 18th MAY 2019SATURDAY, 18th MAY 2019
08.30-09.15 KEYNOTE LECTURE Chair: Domenico Mavilio, University of Milan and Humanitas Research
Hospital, Milan, Italy Natural killer cells in host defense against viral infection Lewis Lanier, University of California, San Francisco, USA
09.20-11.10 SESSION 5 - IMMUNITY TO INFECTIONS Chairs: Emanuela Marcenaro, University of Genoa, Genoa, Italy
Luis Montaner, Wistar Institute, Philadelphia, USA
09.20-09.40 Vaccination, an achievement of civilization Rino Rappuoli, GlaxoSmithKline Vaccines, Siena, Italy
09.40-09.50 Selected abstract
09.50-10.10 Novel immune-based approaches to cure HIV infection Guido Silvestri, Emory University, Atlanta, USA
10.10-10.20 Selected abstract
10.20-10.40 A gut feeling: fatal attraction between HIV and Integrin alfa 4 beta 7 Paolo Lusso, National Institutes of Health, Bethesda, USA
10.40-10.50 Selected abstract
10.50-11.10 Discussion panel
11.10-11.30 Coffee break
11.30-13.00 SATELLITE SYMPOSIUM TBD
13.00-13.30 Break
13.30-14.30 POSTER VIEW
14.30-15.15 KEYNOTE LECTURE Chair: Guido Poli, San Raffaele Institute, Milan, Italy
Innate immunity, inflammation and cancer: double edged swords Alberto Mantovani, Unimed and Humanitas Research Hospital, Milan, Italy
May 16th - 18th, 2019Università degli Studi di MilanoMilan, Italy
5 Innate immunity, inflammation and experimental models of human diseases
International Conference of translational medicineon pathogenesis and therapy of immunomediated diseases
Antonio Sica, University of Piemonte Orientale and Humanitas Research Hospital, Milan, Italy
15.20-15.40 Deciphering the immune landscape of human cancer microenviroment : Massimiliano Pagani, University of Milan and Istituto Nazionale Genetica
Molecolare, Milan, Italy
15.40-15.50 Selected abstract
15.50-16.10 New treatment strategies in the treatment of NSCLC Marina Garassino, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
16.10-16.20 Selected abstract
16.20-16.40 TBD 16.40-17.00 Discussion panel
17.00-17.30 Coffee break
17.30-18.00 MEMORIAL AND TRIBUTE TO THE MASTERS Chairs: Domenico Mavilio, University of Milan and Humanitas Research
Hospital, Milan, Italy Angela Santoni, La Sapienza University, Rome, Italy
17.30-17.40 Vito Pistoia: An outstanding scientist,a wonderful person and an unforgettable friend Lorenzo Moretta, Ospedale Bambin Gesù, Rome, Italy
17.40-17.50 Luigi Varesio: A friend who perceived the role of tumor microphysiology in antitumor immunity Antonio Sica, University of Piemonte Orientale and Humanitas Research Hospital, Milan, Italy
17.50-18.00 Alessandro Moretta: A wonderful journey in the land of NK cells with an unforgettable friend Franco Locatelli, Ospedale Bambin Gesù, Rome, Italy
May 16th - 18th, 2019Università degli Studi di MilanoMilan, Italy
5 Innate immunity, inflammation and experimental models of human diseases
International Conference of translational medicineon pathogenesis and therapy of immunomediated diseases
Innate lymphoid cells: from discovery to cancer treatments Eric Vivier, University of Marseille, Marseille, France
18.45-19.00 FAREWELL Massimo Locati, University of Milan and Humanitas Research Hospital, Milan, Italy Domenico Mavilio, University of Milan and Humanitas Research Hospital,
Milan, Italy Angela Santoni, La Sapienza University, Rome, Italy
