MCMP 407

Receptors and signal transduction in the ANSReceptors and signal transduction in the ANS

Cholinergic Receptors

Nicotinic Muscarinic

Ganglionic Skeletal

Muscle

Neuronal

CNS

MCMP 407

Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: Nicotinic ReceptorsNicotinic Receptors

ACH ACHNa+

MCMP 407

Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: Nicotinic ReceptorsNicotinic Receptors

ACH ACHNa+

NH3

COOH

MCMP 407

Receptors and signal transduction in the ANSReceptors and signal transduction in the ANS

Cholinergic Receptors

Nicotinic Muscarinic

M1 M5M3 M4M2

MCMP 407

Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: Muscarinic receptors are 7 transmembrane domain, G-protein Muscarinic receptors are 7 transmembrane domain, G-protein coupled receptorscoupled receptors

MCMP 407

Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: Muscarinic receptorsMuscarinic receptors(M(M11, M, M33, M, M55))

NH3

COOH

Gq

Phospho -lipase C

(+)

PIP2

IP3 Diacylglycerol

Increase Ca2+ Activate ProteinKinase C

Response

MCMP 407

Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: Muscarinic ReceptorsMuscarinic Receptors

(M2 and M4)NH3

COOH

GI

(-)

ATP cAMP

Reduce cAMP-DependentProtein Kinase Activity

Response

Adenylate Cyclase

X(+)K+

MCMP 407

Receptors and signal transduction in the ANSReceptors and signal transduction in the ANS

Adrenergic Receptors

1A

1 2

1B 1D 2A 2B 2C 1 2 3

MCMP 407

Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: 11-Adrenergic-Adrenergic

ReceptorsReceptors

NH3

COOH

Gq

Phospho-lipase C

(+)

PIP2

IP3 Diacylglycerol

Increase Ca2+ Activate ProteinKinase C

Response

MCMP 407

Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: 22-Adrenergic-Adrenergic

ReceptorsReceptors

GI

(-)

ATP cAMP

Reduce cAMP-DependentProtein Kinase Activity

Response

Adenylate Cyclase

X(+)K+

NH3

COOH

MCMP 407

Receptors and signal transduction in the ANS: Receptors and signal transduction in the ANS: -Adrenergic-AdrenergicReceptorsReceptors

GS

(+)

ATP cAMP

Increase cAMP-DependentProtein Kinase Activity

Response

Adenylate Cyclase

NH3

COOH

MCMP 407

Effector OrganAdrenergicResponse Receptor

CholinergicResponse Receptor

Heart Rate of Contraction Increase 1 Decrease M2

Force of Contraction Increase Decrease M2

Functional Responses Mediated by the ANS

1,

MCMP 407

Functional Responses Mediated by the ANS

Effector OrganAdrenergicResponse Receptor

CholinergicResponse Receptor

Arteries (most) Vasoconstriction 1 ---------- --Veins Vasoconstriction 2 ---------- --Skeletal Muscle Vasodilation 2 ---------- --Endothelium ---------- -- Release EDRF M3

MCMP 407

Functional Responses Mediated by the ANS

Effector OrganAdrenergicResponse Receptor

CholinergicResponse Receptor

LungBronchiolar

smooth muscle

Bronchodilation Bronchoconstriction M32

MCMP 407

Functional Responses Mediated by the ANS

Effector OrganAdrenergicResponse Receptor

CholinergicResponse Receptor

Bladder wall Relaxation 2 Contraction M3

Ureter Contraction 1 Relaxation M3

Sphincter Contraction 1 Relaxation M3

Uterus (pregnant) Relaxation 2 Variable

Penis/vas deferens Ejaculation

Genitourinary, smooth muscle

Contraction M311 M3

Erection

MCMP 407

Functional Responses Mediated by the ANS

Effector OrganAdrenergicResponse Receptor

CholinergicResponse Receptor

Salivary Glands Increase secretion 1 Increase secretionSmooth Muscle:

Relaxation 2 ,2 M3

Sphincters Contraction 1 Relaxation M3

Secretion ---------- -- Increase secretion M3

Gastrointestinal Tract

M3

Walls Contraction

MCMP 407

Functional Responses Mediated by the ANS

Effector OrganAdrenergicResponse Receptor

CholinergicResponse Receptor

Hair follicles,Smooth muscle

Contraction,Piloerection

1 -------------- --

Sweat glandsThermoregulation Increase secretion

Skin

----------------M3

Increase secretion 1Apocrine (stress) ----------------

MCMP 407

Functional Responses Mediated by the ANS

Effector OrganAdrenergicResponse Receptor

CholinergicResponse Receptor

IrisRadial muscle Contraction

Eye

----------------1

-------------Circular muscle M3Contraction--

Ciliary muscle [Relaxation M3Contraction2]

Ciliary epithelium Increase secretionof aqueous humor

----------------2

MCMP 407

Physiology of the eyePhysiology of the eye

LensIris

Radial muscle (1)

Circular muscle (M3)

Canal of Schlemm

Trabecularmeshwork

Ciliary muscle (M3)

Ciliaryepithelium (2)

MCMP 407

Physiology of the eyePhysiology of the eye

MCMP 407

Physiology of the eyePhysiology of the eye

Pupil

Circular muscle

(M3 Receptors)

MCMP 407

Physiology of the eyePhysiology of the eye

Pupil

Contraction of circular

muscle leads to

miosis

MCMP 407

Physiology of the eyePhysiology of the eye

Pupil

Contraction of circular

muscle leads to

miosis

MCMP 407

Physiology of the eyePhysiology of the eye

Pupil

Radial Muscle

( 1 Receptors)

MCMP 407

Physiology of the eyePhysiology of the eye

Pupil

Contraction of radial

muscle leads to

mydriasis

MCMP 407

Functional Responses Mediated by the ANS

Effector OrganAdrenergicResponse Receptor

CholinergicResponse Receptor

Liver Glycogenolysis -------------- --

Fat cells Lipolysis -------------- --

Kidney Increase reninsecretion

1 -------------- --

Pancreas Decrease insulinrelease

Metabolic functions

----------------

1, 3

2

Gluconeogenesis1, 2