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MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was...

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ECoG and cVEMP in definite Meniere's Disease Sasan Dabiri , MD, Assistant Professor Nasrin Yazdani , MD, Associate Professor Payam Abolhasani , MD, Assistant Behrouz Amirzargar , MD, Assistant Nima Rezazadeh , PhD, Audiology Otorhinolaryngology Research Center Otorhinolaryngology - Head & Neck Surgery Department Amir Alam hospital Tehran University of Medical Sciences Tehran, Iran
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Page 1: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

ECoG and cVEMP in definite Meniere's Disease

Sasan Dabiri, MD, Assistant Professor

Nasrin Yazdani, MD, Associate Professor

Payam Abolhasani, MD, Assistant

Behrouz Amirzargar, MD, Assistant

Nima Rezazadeh, PhD, Audiology

Otorhinolaryngology Research Center

Otorhinolaryngology - Head & Neck Surgery Department

Amir Alam hospital

Tehran University of Medical Sciences

Tehran, Iran

Page 2: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

• Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner ear etiology. Baloh RW. Arch Neurol 2001; 58(7):1151-6

• AAO-HNS published a criteria in 1995 for diagnosis of Meniere's disease. Otolaryngol Head Neck Surg 1995; 113(3):181-5

Am J Otol 1993; 14(4):318-25

Background Introduction

Methods

Results

Discussion

ConclusionProsper Meniere (1792-1862)

Painted Portrait in 1833

Page 3: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Background Introduction

Methods

Results

Discussion

Conclusion

• Electrocochleography (ECoG) which is a measurement of the electrical potentials generated by cochlea and auditory nerve, has very long developmental history and applied after about 50 years for first time in patients with Meniere’s disease. Coats AC. Arch Otolaryngol 1981; 104(4):199-208

• Because of some normal results, it is not a diagnostic modality by itself. Oh KH, et al. Arch Otolaryngol 2014; 134(8):771-5

Page 4: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Background Introduction

Methods

Results

Discussion

Conclusion

• Vestibular evoked myogenic potential (VEMP) which originally was applied in clinical settings in 1992, is a response in muscles to sound or electric stimulation. Colebatch JG, Halmagyi GM. Neurology 1992; 42(8):1635-6

• Saccular involvement as a second frequent site after cochlea in Meniere’s disease leads to common use of this test. Adams ME, et al. Otolaryngol Clin N Am 2010; 43(5):995-1009

• Nevertheless, VEMP cannot be an effective diagnostic test. Egami N, et al. J Vestib Res 2013; 23(4-5):249-57

Page 5: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Purpose of Study Introduction

Methods

Results

Discussion

Conclusion

Presence of a few studies about both

these tests in the same patients with

Meniere’s disease

Lack of evidence with main purpose of

evaluation of diagnostic correlation of

these two tests

Page 6: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner
Page 7: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Patient enrollment• Study Design:

• Prospective observational study

• Population: • Patients with Meniere’s Disease in ENT clinic at tertiary hospital

• Inclusion Criteria: • definite Meniere’s disease (AAO-HNS criteria)

• Exclusion Criteria: • Other otologic disorders or surgery or intervention• Neurologic disorder• Musculoskeletal disorder

Introduction

Methods

Results

Discussion

Conclusion

Page 8: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

• Electrocochleography

Extratympanic electrode with click stimulus sound

• Elevated or abnormal: • SP to AP amplitude ratio greater than 0.4

• not-elevated: • Ratio equal or less than 0.4• Patients without any wave due to significant SNHL

Test SetupIntroduction

Methods

Results

Discussion

Conclusion

Page 9: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Test Setup• Cervical Vestibular Evoked Myogenic Potential Test

Tone burst stimulation sound (500 Hz and 95 DB)

• Negative or abnormal: • No wave• Increased stimulation threshold• Decreased amplitude• Abnormal morphology

Introduction

Methods

Results

Discussion

Conclusion

Page 10: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Statistical MethodsIntroduction

Methods

Results

Discussion

Conclusion

Descriptive

Mean ± SD

Median

Frequency

Analytic

Difference

Chi square

Fisher exact

Analytic

Correlation

Pearson

Spearman rho

Page 11: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner
Page 12: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Descriptive Findings62 patients, Mean age: 44 ± 13 years

• Duration of disease: Mean: 47 months , Median: 30 months

Introduction

Methods

Results

Discussion

Conclusion

male42%female

58%

Gender

Left Ear, 27

Both Ears,

6

Right Ear, 29

Site of Lesion

Page 13: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Analytic FindingsIntroduction

Methods

Results

Discussion

Conclusion

Test Battery ResultscVEMP (%)

Normal Abnormal

ECoG (%)Normal 6 18

Abnormal 23 53

No statistically significant difference between two tests (p-value:1.00)

Page 14: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Test Battery ResultscVEMP (%)

Normal Abnormal

ECoG (%)Normal 6 18

Abnormal 23 53

Analytic FindingsIntroduction

Methods

Results

Discussion

ConclusionOverall Abnormal: 71%Overall Abnormal: 76%

Page 15: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Analytic FindingsIntroduction

Methods

Results

Discussion

Conclusion

Clinically Ear involved

(n)

Abnormal ECoG results(%)

Abnormal cVEMP results(%)

Right Left Both None Right Left Both None

Right side (29) 62 0 17 21 28 7 31 34

Left side (27) 7 63 4 26 0 44 26 30

Both side (6) 17 0 50 33 17 0 83 0

No statistically significant difference between subgroups of two tests

Page 16: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Analytic FindingsIntroduction

Methods

Results

Discussion

Conclusion

Clinically Ear involved

(n)*

Ipsilateral Abnormal

ECoG(%)

Ipsilateral Abnormal

cVEMP(%)

Ipsilateral Abnormal ECoG

and cVEMP(%)

Ipsilateral Abnormal ECoG

or cVEMP(%)

Right side (35) 77 66 46 97

Left side (33) 64 73 48 88

* Patients with unilateral each side or bilateral involvement were included for each side.

Page 17: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Analytic Findings

Correlation

• ECoG & cVEMP test: not significant (p-value: 0.82)

• ECoG & gender: not significant (p-value: 0.31)• ECoG & age: not significant (p-value: 0.83)• ECoG & duration: not significant (p-value: 0.80)

• cVEMP test & gender: not significant (p-value: 0.86)• cVEMP test & age: not significant (p-value: 0.30)• cVEMP test & duration: not significant (p-value: 0.82)

Introduction

Methods

Results

Discussion

Conclusion

Page 18: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner
Page 19: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

• ECoG and cVEMP test are two audiovestibular tests proposed as complement for diagnosis of Meniere’s disease. Semaan MT, Megerian CA. Otolaryngol Clin N Am 2011; 44(2):383-403

• Probability of abnormal findings in any of both tests (when both considered as one test) in definite Meniere’s disease is noticeable (Right side: 97% , Left side: 88%)

• Lack of correlation between the results of two tests may enhance the mentioned diagnostic application.

Main OutcomesIntroduction

Methods

Results

Discussion

Conclusion

Page 20: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

• Murphy et al. Otolaryngol Head Neck Surg 2007; 137(2 suppl):P144

Objective: Superiority of ECoG to VEMP in Meniere’s disease

Literature ReviewIntroduction

Methods

Results

Discussion

Conclusion

Parameters for comparison Murphy et al. Current study

Number of participants (n) 117 62Abnormal ECoG and cVEMP (%) 27 53Abnormal ECoG with Normal cVEMP (%) 73 23Abnormal cVEMP with Normal ECoG (%) 0 18Normal ECoG and cVEMP (%) ? (0) 6

Page 21: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Literature Review• Murphy et al. Otolaryngol Head Neck Surg 2007; 137(2 suppl):P144

Objective: Superiority of ECoG to VEMP in Meniere’s disease

• Comparative Analysis and Interpretation:• Differing study population

• Only definite Ménière’s disease• Phase of disease• Different pathophysiologic states in Meniere’s disease

• Difference in test setup• Various stimulus types• Multiple ways for performing tests• Diversity in defining abnormality

Introduction

Methods

Results

Discussion

Conclusion

Page 22: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Literature Review• Wu et al. Lin Chuang Er Bi Yan Hou Ke Za Zhi 2006; 20(10):433-5

Objective: Vestibular test battery & ECoG in Meniere’s disease

Introduction

Methods

Results

Discussion

Conclusion

Parameters for comparison Wu et al. Current study

Number of participants (n) ? 62Abnormal overall ECoG (%) 76.9 75.8Abnormal overall VEMP (%) 58.0 71.0Canal paresis with caloric test (%) 50.0 ---Correlation between any of tests and duration of Meniere’s disease Not significant Not significant

Page 23: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Literature Review• Wu et al. Lin Chuang Er Bi Yan Hou Ke Za Zhi 2006; 20(10):433-5

Objective: Vestibular test battery & ECoG in Meniere’s disease

• Comparative Analysis and Interpretation:• Differing study population

• Only definite Ménière’s disease• Age effect on cVEMP results (false positive in patients older than 60 yrs)

however, specific analysis in the study rejected age effect• Difference in VEMP test setup

• Various stimulus types• Multiple ways for performing tests• Diversity in defining abnormality

Introduction

Methods

Results

Discussion

Conclusion

Page 24: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Limitations of Study• Selection bias

• Participants included were from a tertiary center; so, they may have different severity and extension of disease compared to overall patients with Meniere’s disease in the community

This point may affect the results This result may have limited generalizability (external validity)

Introduction

Methods

Results

Discussion

Conclusion

Page 25: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Limitations of Study• Selection bias

• Participants included were from a tertiary center; so, they may have different severity and extension of disease compared to overall patients with Meniere’s disease in the community

• This point may affect the results• This result may have limited generalizability (external validity)

Larger study in various centers could clarifying this haze deduction

Introduction

Methods

Results

Discussion

Conclusion

Page 26: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Further Research• Their results could be helpful to predict progression to

definite disease or contralateral involvement.

• In addition, they may have the potency to include in the diagnostic criteria of Meniere’s disease with further research on various vestibulocochlear tests.

• Test results may be assessed for use in follow up especially after interventions like intratympanic injection or endolymphatic sac surgery.

Introduction

Methods

Results

Discussion

Conclusion

Page 27: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

Despite of some beneficial helps for diagnosing Meniere’s disease, neither ECoG nor cVEMP cannot be used lonelyas a diagnostic modality.

Combination of both tests for diagnosis may be helpful: High positive findings when applying both as one test

No significant correlation between tests

Introduction

Methods

Results

Discussion

Conclusion

Page 28: MD, Assistant Professor MD, Associate Professor MD ... Congress - Italy.pdf · Meniere was described a series of similar patients in 1861 and changed mentality from cerebral to inner

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