4/3/13

1

Mechanics of Cell Division

László Grama 2 April, 2013

The Cell Cycle

Alberts. Molecular Biology of the Cell. 4th Edition

4/3/13

2

Cytoskeletal Machines Perform Both Mitosis and Cytokinesis

Alberts. Molecular Biology of the Cell. 4th Edition

M Phase in Animal Cells Depends on Centrosome Duplication in the

Preceding Interphase

Alberts. Molecular Biology of the Cell. 4th Edition

4/3/13

3

M Phase in Animal Cells Depends on Centrosome Duplication in the Preceding Interphase

Alberts. Molecular Biology of the Cell. 4th Edition

M Phase Is Traditionally Divided into Six Stages A

lber

ts. M

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ular

Bio

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he C

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4th E

ditio

n

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4

Three Classes of Spindle Microtubules

Microtubule Instability Increases Greatly at M Phase

Alberts. Molecular Biology of the Cell. 4th Edition

4/3/13

5

Interactions Between Opposing Motor Proteins and Microtubules of Opposite Polarity Drive Spindle

Assembly

Alberts. Molecular Biology of the Cell. 4th Edition

Kinetochores Attach Chromosomes to the Mitotic Spindle

Alberts. Molecular Biology of the Cell. 4th Edition

4/3/13

6

Microtubules Are Highly Dynamic in the

Metaphase Spindle

Alberts. Molecular Biology of the Cell. 4th Edition

Opposing forces may drive chromosomes to the metaphase plate

Alberts. Molecular Biology of the Cell. 4th Edition

4/3/13

7

Sister Chromatids Separate Suddenly at Anaphase

Alberts. Molecular Biology of the Cell. 4th Edition

Kinetochore Microtubules Disassemble at Both Ends During Anaphase A

Alberts. Molecular Biology of the Cell. 4th Edition

4/3/13

8

Both Pushing and Pulling Forces Contribute to Anaphase B

Alberts. Molecular Biology of the Cell. 4th Edition

Actin and Myosin II in the Contractile Ring Generate the Force for Cytokinesis

Alberts. Molecular Biology of the Cell. 4th Edition