Prepared by:Dr. Mohammad Shaikhani.

MBChB-CABM-FRCP.

Pancreatic cancer:• Deaths from pancreatic ductal adenocarcinoma or pancreatic

cancer, fourth among cancer-related• Pancreat ic cancer is more common in elderly persons than in

younger person• < 20% present with localized, potentially curable tumors.• The overall 5-year survival rate among patients with pancreatic

cancer is <5%.• The causes of pancreatic cancer remain unknown.• Several environmental factors implicated, but evidence of a

causative role exists only for tobacco use. • Smokers have a 2.5-3.6% increase in the risk& increases with

greater tobacco use& longer exposure

Pancreatic cancer:• Possible roles of:• Moderate intake of alcohol, coffee, aspirin,diabetes or chronic

pancreatitis, chronic cirrhosis, a high-fat, high-cholesterol diet, previous cholecystectomy,blood type A, B, or AB as compared with blood type O.

• 5 -10% have a family history, in some, as part of a well-defined cancer-predisposing syndrome

• The risk is 57 times as high in families with four or more affected members as in families with no affected members.