med.asu.edu.egmed.asu.edu.eg/uploads/med/MD_histology_5.doc · Web viewThe Department of Histology...

Faculty of MedicineFaculty of MedicineAin Shams UniversityAin Shams University

Postgraduate StudiesPostgraduate Studies

Medical Doctorate in Histgologyالخلية و األنسجة علم فى الدكتوراه درجة

Program Code: HI700

Program Guide and Logbook

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Candidate Curriculum vitae

[Name] Please attach your recent photo

[telephone no] [mobile no][mailing address]

[email address][postcode]

Experience[organization] [your present job title][start date][location][responsibilities]

[organization] [previous job title][start and end date][location]

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[responsibilities][organization] [previous job title][start and end date][location][responsibilities]

Education[certificates][start and end date][school or college]

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Training[any other training that will be useful in your job]

Date of Registration

First semester _______________________

Second semester _______________________

Third semester _______________________

Fourth semester _______________________

Fifth semester _______________________

Sixth semester _______________________

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TABLE OF CONTENTS:

PageI – Welcome StatementII - Mission StatementIII – Senior supervisor and affiliated departments and HospitalsIV – Program specifications 1 - Basic Information 2 - Professional Information 3 – Academic standards 4 - Curriculum structure and contents 5 - Program courses: 6. Program admission requirements: 7. Regulation for progression and program completion

8. Appendix: course specification1. Histology2. Tissue culture3. Cytogenetics4. Immunology5. Molecular biology.

V - General informationVI – Your log book 1 - Introduction 2 - Supervisors 3 - Tables for training records 4 – Log book previewVII - Head of department approval for the exam entry

Detachable forms

VIII – Thesis follow upIX - Evaluation forms

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I – Welcome Statement:The Department of Histology welcomes you to Doctorate degree of Science in

Histology. As a department we are committed to medical student education and continuously strive to improve your educational experience.This handbook presents information guide and logbook activity of the Medical Doctorate degree in Histology administered by the Histology department, Faculty of Medicine, Ain Shams University.

II - Mission Statement:The mission of the Faculty of Medicine, Ain Shams University is

• The preparation of a competent graduate, who is able to compete on both national and regional levels, capable of life long learning, training and tutoring, while adhering to the codes of practice of medical health services and ethics.

• The college as well, seeks continuous development of programs and courses. It also enhances expansion of applied scientific research and health programs for community services and environmental development.

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The mission of this degree is to prepare a professionally trained researcher and lifelong tutor capable of following standards of scientific teaching and ethics, with professional managerial and technical skills in his specialty.

III – Senior Supervisor and A ffilated Departments and Hospitals Senior SupervisorProf.---------------------------------------------------------------------------------------------E-mail:

A ffilated Departments and Hospitals Histology Department, Faculty of Medicine, Ain Shams University.

IV – Program Specifications

A- Basic Information

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1. Program title:Doctorate Degree of Science in Histology

2. Program type: Single Double Multiple

3. FacultyFaculty of Medicine, Ain Shams University.

4. DepartmentHistology.

5. Assistant co-ordinator………………………………………………………6. Co-ordinator……………………………………………………….7. Last date of program approval:

30/7/2009

B- Professional Information:1. Program aims:

Preparation of a well qualified lecturer, mastering accurate and up-to-date knowledge in his specialty. Furthermore, the candidate should be monitoring professional level of histological skills following ethical standards.

2. Intended learning outcomes (ILOs):

a. Knowledge and understanding:By the end of the program the candidate will be able to:

a1 – Describe the structure of the cell and different tissues of the body using light and electron microscopes.a2 – Identify the structure of all systems of the body.a3- Recognize basic knowledge of immunohistochemical, cytogenetic, molecular biological, and statistical sciences. a4- Select the proper microtechniques suitable for histological, immunohistochemical, cytogenetic, and tissue culture to identify different tissues of the body.

b. Intellectual capabilities:By the end of the program the candidate will be able to:

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b1- Correlate the structure to the function of different tissues of the body.b2 – Compare/contrast the structure of different tissues of the body; using different microtechniques.b3– Interpret the light and ultrastrcture of different body tissues.b 4- Choose proper techniques to identify different body tissues.

c. Professional and practical skills:By the end of the program the candidate will be able to:

c1- Prepare tissues’ paraffin blocks, ultrathin resin sections and slides propely. c2 Stain different body tissues using different techniques. c3 Identify different tissue structure using light and electron microsopes.

d. General and transferable skills:By the end of the program the candidate will be able to:

d1 – Present a power point presentation. d2 – Prepare a joint discussion paper. d3 – Use e-learning for self study.

3. Academic standards: (Benchmarks)Academic reference standards guided by Georgetown University School of Medicine (SOM).

som.georgetown.edu/prospectivestudents/ 4. Curriculum structure and contents:4a- Program duration: 6 semesters (minimum 3years).5.1- CompulsoryCode number Course title No of hours

Lect. Lab. Exer.HI7001 Histology 150hs 300hs 480hs

5.2- Elective- one is requiredCode number Course title No of hours

Lect. Lab. Exer.E7009 Tissue culture 15 hs 30 hs -E7010 Cytogenetics 15 hs 30 hs -E7011 Immunology 15 hs 30 hs -E7012 Molecular biology 15 hs 30 hs -

6. Program admission requirements:

الدكتوراه): :-7المادة ( درجة على للحصول الطالب لقيد يشترط

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األساسية- 1 المواد إحدى أو التخصص مادة في الماجستير درجة على حاصال يكون أن

لها . معادلة درجة على أو المصرية الجامعات إحدى من بها جهة -2المتصلة موافقة

الدراسة متطلبات على وإستهالك- 9 .العمل التدريب ومصاريف الرسوم تسديد

الملحق ( في المطلوبة المستندات وإستيفاء لمدة- 10 0) 2األجهزة للدراسة التفرغ

. يتم أن ويمكن الثاني الجزء امتحان دخول قبل األقل على دراسية خمسفصول

المعتمدة العلمية المراكز أو المستشفيات احد فى األقل على المدة لنفس التدريب

. المختصة األقسام تحددها التى الشروط أستيفاء بعد الكلية من7. Regulation for progression and program completion

يوليو : ): 8مادة ( أول من األولى العام فى مرتين الدكتوراه لدرجات التسجيل يتم

حتى نوفمبر أول من والثانية أغسطس آخر ديسمبر حتى 0آخر

منهما ): 9مادة ( كل مدة دراسيين فصلين على جامعى عام كل فى الدراسة توزع

. مع . فبراير منصف فى الثانى ويبدا أكتوبر أول فى االول يبدا اسبوعا عشر خمسة

للفصل . التسجيل يتم و اسابيع ستة لمدة مكثف صيفى دراسى فصل الدراسى تنظيم

. المسجلة المقررات حسب الشروط إستيفاء بعد االقل على بدايته من اسبوعين قبل

عن الواحد الفصل فى الدراسى العبء يزيد أن . 6والينبغى ويجوز معتمدة ساعات

او ( بالحذف الدراسى الفصل بداية من اسبوعين خالل المقررات تعديل للطالب

احتسابه ). دون المقرارت احد من اسابيع سته خالل االنسحاب له يجوز كما االضافة

. فيه راسبافصول ( ): 17مادة ( ست شهرا وثالثون ستة الدكتوراه على للحصول الدراسة مدة

للساعات) طبقا بالقسم متكامال تدريبيا برنامجا الطالب خاللهم يجتاز دراسية

متابعة كتيب فى منه المطلوب خاللها الخامسويستوفى بالباب الموضحة المعتمدة

م األنشطة المطلوب أرباع ثالثة إستيفاء قبل اإلمتحان بدخول له يسمح من وال نه

المعتمدة . الساعات

للدكتوراه ): 18مادة ( األول الجزء في الدراسة وجد مدة يجتاز إن واحد دراسي فصل

الجزء في للدراسة لإلنتقال بالكامل فيه النجاح يشترط وال إمتحانا الطالب بعده

الجامعية المستشفيات بإحدى التدريب خاللها ويشترط المراكز الثاني المعتمدةأو

الخارج أو بالداخل سواء بالكلية العليا الدراسات ولجنة القسم يتم من أن على

المعتمدة للساعات طبقا الدراسة . إستكمال

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الرسالة ): 19مادة ( موضوع بتسجيل الدكتوراه لدرجة الدارس القيد يقوم للدرجةمع

لها توال يخصص وال للدرجة التسجيل على عامين مرور قبل الرسالة مناقشة جوز

درجات.

التسجيل ): 20مادة ( قبل الجامعة متطلبات بإستيفاء الدكتوراه لدرجة الدارس يقوم

الكلية الرسالة ومتطلبات الثاني ومناقشة الجزء إمتحان دخول ومتطلبات .قبل

مجموع ( اإلنجليزية اللغة في التويفل شهادة على الحصول هي )550الجامعة درجة

فى بالكلية العليا الدراسات لجنة من معتمدة دورات حضور هى الكلية ومتطلبات

تحددها خاصة إختبارات إجتياز أو الطبي واإلحصاء الطبية والدراسات التخطيط مجال

اللجنة. الدكتوراه ): 21مادة ( لدراسة المعتمدة و الساعات ست منها ساعة تسعون و ست

يضافستون و الماجستير اثناء دراستهم تمت ساعة األقل معتمدة ساعة ثالثون على

متابعة لكتيب ساعة خمسعشرة منها ساعة األنشطة ويخصص وخمسعشرة

األول للجزء األقل على ساعات وست وجد للرسالة . إن

): 22مادة ( بناءا الجامعة لمجلس ويجوز خمسسنوات الدكتوراه لدرجة القيد مدة

مجلس طلب بعد بالكلية العليا الدراسات لجنة موافقة وبعد الكلية مجلس طلب على

بإضافة السماح الطالب على المشرفين جميع من سنوية تقارير إلى وإستنادا القسم

واحد .عام الدكتوراه درجة على للحصول القيد تاريخ من سنوات ثمان أقصى وبحدا ت): 23مادة ( ب لتزم المرتبطة المواد أقسام مع باألشتراك المعنية وضعالقسام

وقصيرة طويلة أسئلة من المختلفة التقييم وسائل تشمل موضوعية إمتحانات

أن على المختلفة المهارات تقيس مقننة إكلينيكية وإختبارات ، اإلختيارات ومتعددة

بالكلية . العليا الدراسات لجنة من وتعتمد ذلك تفاصيل المناهج كراسة تشملللدكتوراه ): 24مادة ( النهائى االمتحان درجات منها 1500مجموع درجة 300درجة

. الف المعدل اليها ويضاف وجد إن األول يوازى صللجزء بما التراكمى . 400لى

إمتحان ): 25مادة ( ويعقد عام كل من ونوفمبر أكتوبر في األول الدور إمتحان يعقد

. عام كل من ومايو أبريل فى الثاني الدورعلى ):26مادة ( الحصول بعد الدكتوراه مواد فى النجاح درجة% 60يكون من

. حدة على كل والشفوي واالكلينيكى والعملي التحريري Assessment Schedule and Weighing of Assessments:

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للنقاط: طبقا الطالب درجات تعادل التالى ملحوظة الوجه على :

4:فأكثر % 90 -1 نقاط

A

أقل% 85من- 2 حتى 3.67: %90من

نقاط

A-

أقل% 80من -3 حتى 3.33:%85من

نقاط

B+

أقل% 75من -4 حتى 3.00:%80من

نقاط

B

أقل% 70من -5 حتى 2.67:%75من

نقاط

B-

أقل% 65من -6 حتى 2.33:%70من

نقاط

C+

أقل% 62من- 7 حتى 2.00:%65من

نقاط

C

أقل% 60من -8 حتى 1.67:%62من

نقاط

C-

من -9 Fصفر:%60أقلالفصلى ( المعدل حساب كل) GPAويتم نقاط ضرب حاصل أساسمجموع على

للمقررات المعتمدة الساعات على مقسوما المعتمدة ساعاته عدد فى مضروبا مقرر

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. حساب يتم كما الدراسى الفصل فى الطالب درسها للطالب ( التى التراكمى المعدلCGPA (كل فى الطالب عليها حصل التى النقاط ضرب حاصل أساسمجموع على

المعتمدة الساعات مجموع على مقسوما المعتمدة ساعاته عدد فى مضروبا مقررالكلية.

من مجموعة أو مادة فى الرسوب حالة أ مقررات الفى الدبلوم أووالماجستير فى. الدكتوراه فقط المجموعة أو المادة فى اإلعادة الذى يتم الفعلى التقدير حساب ويتم

تقدير النجاح عند له فيحسب رسوبة تكرر إذا أما فقط إعادة أول فى عليه يحصلاى% (60 اى 1.67فقط .)C-نقاط

Histology course specificationUniversity: Ain Shams Faculty: Medicine

Course specificationsCourse specificationsProgram on which the course is given: Medical Doctorate Degree in HistologyMajor or minor element of programs: Major Department offering the program: Histology department.Department offering the course: Histology department.Academic Level: MD – 1st till 6th semesterDate of specification approval: …………………………..

A- Basic InformationTitle: Histology course Code: HI7001

Title: Histology course Code: HI7001Credit Hours: 28 Lecture: 2h/week Total: 150hs Practical: 4 hs/week Total: 300hs Activities: 8 hs/week Total: 480hs CoordinatorHistology department

B - Professional Information1- Course Aims:1- Overall aims of the course: The focus of this course is the accurate and up-to-date understanding of the microscopic structure of cells, organs, and systems in the human body and the direct relationship between the morphology (microscopic structure) of such an organ and its function. The systemic histology course is a continuation of the basic course and it will focus on the clinical and physiological aspects of the organs and its microscopic structure as well as the demonstration of the interaction of

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histology with other basic medical sciences such as human anatomy (Gross), physiology, biochemistry, cell biology, and Pathology. The Course will summarize the applications of basic histology and illustrate the morphological features of organs and systems however; this section has a direct connection between the microscopic structure of the organ and clinical notes about it.2- Intended Learning Outcomes (ILOs) from the Course:

a) Knowledge and understanding: By the end of the course the student should be able to:

a1- Identify the microscopic structure of different cells, tissues and organs of the bodya2- Recognize the ultrastructure of different cells, tissues and organs of the bodya3- Correlate between the structure and function of different cells, tissues and organs of the body

b) Intellectual skills: By the end of the course the student should be able to:

b1- Integrate basic histological, anatomical, biochemical and physiological knowledge with clinical datab2- Interpret the structural changes in cells to understand the underlying cause for different diseasesb3- Retrieve, analyze and interpret the collected information in lectures, library and searching for solving problems related to structural dysfunction

c) Professional and practical skills: By the end of the course the student should be able to: c1- Adjust and deal properly with the light microscopec2- Determine the proper magnification for examining the different cells, tissues and organs.c3- Identify and draw the microscopic structure of different cells, tissues and organs provided.

d) General and transferable skills: By the end of the course the student should be able to:

d1- Respect his colleagues and work properly in a team d2- Be aware with human and animal research ethicsd3- Comply with different believes in the community they serve

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3- Course content:

Topic actually taught Lectures (2hrs) PracticalMicrotechniques 3 6Cell and its componentsCell membraneCytoplasmic organellesCytoplasmic inclusionsCytoskeletonNucleus

7 14

EpitheliumConnective tissue

5 10

CartilageBone

5 10

Muscle tissueNervous tissue

5 10

Blood 5 10Vascular tissue & skin 5 10Respiratory system 5 10Digestive system and glands 6 12Endocrine system 4 8Urinary system 4 8Male reproductive system 4 8Female reproductive system 4 8EyeEarReceptors

5 10

CNS 8 16

Teaching and learning methods:- Lectures- Practical sessions for demonstration of slides of different cells, tissues and organs with discussion 3) Student assessment:- MCQ: To assess knowledge and understanding- Practical exam: -To assess the ability to identify the structure of different cells, tissues and organs using light microscope. - to assess the practical skills in preparing different histological sections using different techniques for microscopic examination.

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- Essay Qs: To apply histological knowledge in a comprehensive written way to assess the degree of understanding- Oral Exam: To assess the ability of students to explain the structure of cells, tissues and organs in a comprehensive oral way

Weighting of assessment: o Written exam 800 o Oral exam 150o Practical exam 450o Semesters’ assessment 400o Total 1900 4) List of references: - lecture notes prepared by staff of the department - Essential books - Basic Histology. Text and Atlas 2005. - Functional Histology - Color textbook of Histology. Gartner& Hiatt.

- Core text of neuroanatomy - Bloom and Fawcett Histology. A text book of Histology.

- Ham’s Histology.-Essential Histology.-Molecular Biology in Medicine. Cox T.M. and Sinclair J.-Principles of Medical Genetics. T. B. Geleherter and F.S. Collins.-Basic Molecular Genetics. R.Shalaby.

- Periodicals and web sites:- http://en.wikipedia.org/wiki/Histologywww.najah.edu/nnu_portal/file/faculties/.../ Histology som.georgetown.edu/73239.htmlwww.visual histology .com/

II. Elective Courses (only one is required):

A. Tissue Culture Course specificationsUniversity: Ain Shams Faculty: Medicine

Course specificationProgram on which the course is given: Medical Doctorate Degree in Histology

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http://www.visualhistology.com/

http://www.najah.edu/nnu_portal/file/faculties/.../Histology

http://en.wikipedia.org/wiki/Histology

Major or minor element of programs: Minor Department offering the program: Histology department.Department offering the course: Histology department.Academic Level: MD – 2nd, 3rd or 4th semester Date of specification approval: …………………………..

A- Basic InformationTitle: Tissue Culture Code: E7009Credit Hours: 2 Lecture: 1h/w Total: 15hs Practical: 2h/w Total: 30hsCoordinator

Histology department

B - Professional Information

1- Course Aims:Overall aims of the course: The focus of this course is the basic understanding of live cells and tissues outside the body. Moreover it is helpful in isolating the effect of a single moclecule on one type of cell or tissue.

2- Intended Learning Outcomes (ILOs) from the Course:a- Knowledge and understanding By the end of the course the candidate will be able to:a1 – Describe the proper complex solution suitable for growth of different cells and tissues.a2 – Identify parasites, and viruses that grow only within cells. a3 – State anomalies in the number and morphology of chromosomes in a cultured cell during mitotic division.

b- Intellectual skillsBy the end of the course the candidate will be able to: b1- Apply tissue culture for the study of the metabolism of normal and cancerous cells. b2 – Extend tissue culture study in developing new drugs.

c- Professional skillsBy the end of the course the candidate will be able to:c1- Observe the behavior of living cells under the microscope.

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c2- Reproduce in vitro-experiments which can’t be performed in living animals.c3- Isolate cells.c4- Cultivate cells in a suspension.

d- General and transferable skills By the end of the course the candidate will be able to:d1 - Respect his colleagues and work properly in a team. d2- Be aware with human and animal research ethics.d3- Comply with different believes in the community they serve.

3- Course content:

Topics No. of hoursL T C/P SDL

Cell division (mitosis, meiosis) 2hs 1hs 6hs -Tissue Culture 2hs 2hs 9hs -Immunogenetics 2hs 2hs 9hs -Cloning 2hs 2hs 6hs -

L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed learning

4 - Student Assessment Methods4.1 written exam to assess basic knowledge and understanding.

Weighting of assessmentWritten 100Total 1005 -- List of References5.1- Course Notes (paper and / or electronic)5.2- Essential Books (Text Books)1) Culture of animal cells . A manual of basic techniques(fourth edition, Wiley Press,2000)2) Basic cell culture. Aparctical approach. (IRL Press,2000)3) Epithelial cell culture Apractical approach. (IRL Press, 2000)4) Stem cell transplantation (Wiley-VCH, 2006)

B. Cytogenetics course specification

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University: Ain Shams Faculty: Medicine

Course specificationProgram on which the course is given: Medical Doctorate Degree in HistologyMajor or minor element of programs: Minor Department offering the program: Histology department.Department offering the course: Genetics unit, department of pediatrics. Academic Level: MD at any semester Date of specification approval: …………………………..

A- Basic InformationTitle: Cytogenetics Code: E7010Credit Hours: 2 Lecture: 1h/w Total: 15hs Practical: 2h/w Total: 30hsCoordinator

Genetics unit, department of pediatrics.

B - Professional Information1- Course Aims:Overall aims of the course:

The aim of the course is:This course is designed to give students a basic knowledge of the principles of Genetics. It also gives them an idea about genetic anomalies and who they are incorporated in different genetic disorders and inherited diseases. Students will also learn different diagnostic data in order to provide genetic risk assessment and best genetic advice to individuals and their families in an ethical way.

1- Intended learning outcomes (ILOs):

a- Knowledge and understanding:By the end of this course the student are able to develop an understanding of:a1. Chromosomal disorders and methods used to characterize the underlying chromosomal abnormality.a2. The molecular basis of inherited disease, diagnostic methods which are used to identify the causative mutations in patients or carriers.a3. Treatments and therapy for inherited disease and cancer, including novel therapies such as gene therapy.

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a4. The principles and practice of population screening programs for inborn errors of metabolism, prenatal identification of pregnancies at risk of chromosomal disorders.a5. The ethical issues which are an inherent part of Medical Genetics.

b- Intellectual skills:By the end of this course the student should be able to:b1. Identify children with suspected genetic condition and to direct them to the proper investigation.

c- Professional and practical skillsBy the end of this course the student should be able to:c1. Apply their knowledge base in Medical Genetics in using clues from pedigree, family history and other information to suggest likely inheritance patterns and / or diagnoses.c2. Select the diagnostic or screening methods which will be most appropriate and informative in a given clinical situation whilst taking into account referring them to a geneticist.

d- General and Transferable/key skillsBy the end of this course the student should be able to:d1. Acquire time management skills to accomplish individual designated tasks by a given date;d2. Write scientific report and get oral presentation skills.d3. Critically use of online databases and e-journals;

Course Contents:L: Lecture, C/P: Clinical or Practical and SDL: Self directed learning

TopicNo. of hours

L C/P

SDL

Bas

ic g

enet

ics

Gene structure and gene function 2 4Organization and structure of chromosomes, karyotype, nomenclature and interpretation of abnormal karyotypes and chromosomal aberrations

2 4

Mutations and teratogens 2 4Pedigree construction, Patterns of inheritance: traditional patterns & non-traditional patterns of inheritance.

2 4

Di 1. Molecular Diagnostic Techniques. 2 4

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agno

stic

2. Cytogenetic Diagnostic Techniques.3. Biochemical Diagnostic Techniques.

Man

agem

ent o

f ge

netic

dis

ease

s

1. Dietary therapy: restriction – supplementation 2 42. Drug therapy3. Transplantation therapy: cell - tissue - organ 4. Stem cell therapy5. Surgical intervention6. Gene therapy

Immunogenetics: HLA system 3 6

4- Student Assessment Methods4.1- Short essay to assess knowledge.4.2- MCQs to assess knowledge.Weighing of assessment4.1 written exam 100Total 100

5- List of references:5.1- Course Notes (paper and / or electronic)Lectures (handouts – electronic)

5.2- Essential Books (Text Books)Davidson’s principle and practice of MedicinePrimer of rheumatic diseases

5.3- Recommended Books……………………………………………………………………………………5.4- Periodicals, Web Sites, etchttp://books.google.com/books?id=dMIFiNR0I7YC&pg=PA5&lpg=PP1&ots=ptiuYq7bNq&dq=genetics+in+rheumatology

C. ImmunologyUniversity: Ain Shams University Faculty: of Medicine

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http://books.google.com/books?id=dMIFiNR0I7YC&pg=PA5&lpg=PP1&ots=ptiuYq7bNq&dq=genetics+in+rheumatology



Course specificationsProgram on which the course is given: Doctorate of Science in Histology.Major or minor element of programs: Minor. Department offering the program: Histology department.Department offering the course: Microbiology and Immunology department.Academic Level: Doctorate – at any semester Date of specification approval: …………………………..

A- Basic InformationTitle: microbiology course Code: E7011Credit Hours: 2 hours Lecture: 2hs/week Total: 30hsCoordinatorMicrobiology and Immunology department.

B - Professional Information1- Course Aims:1-To provide candidates with an understanding of the immune system, its protective functions and its role in the patho-physiology of infectious and non- infectious diseases2- To enable the candidates to practice the principles of sterilization and infection control.

2- Intended Learning Outcomes (ILOs) from the Course:a- Knowledge and understandingBy the end of the course the candidate will be able to:a1- Explain the physiology of the immune system, its beneficial role, as well as its detrimental role in hypersensitivity, autoimmunity and transplant rejection.a2- Describe recombinant DNA biotechniques.

b- Intellectual skillsBy the end of the course the candidate will be able to: b1- Interpret immunological and molecular reportsb2- Report and appraise a concise scientific activity according to standard scientific thinking and integrity

c- Professional skillsBy the end of the course the candidate will be able to:c1- Identify culture media and biochemical tests commonly used for bacterial identification and distinguish positive and negative resultsc2- Perform hand wash and control of steam sterilizationc3- Select the proper investigation.

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d- General and transferable skills By the end of the course the candidate will be able to:d1- Work effectively in a group during preparation of seminars. d2- Respects the role of staff and co-staff members regardless of degree or occupation.

3- Course content:

Topics No. of hoursL

Basic immunology: Tissues and cells of immune response, types of immune response, Immunoglobulins, Humoral immune response, complement, Ag-Ab reactions Cell-mediated immunity, Cytokines, immunity to bacterial infection and immunoprophylaxis

15

Hypersensitivity 5Autoimmunity and tumor Immunology 5Immupodeficiency and infections in immunocompromized host 5L: Lecture

4 - Student Assessment Methods4.1written exam to assess knowledge and understanding

Weighing of assessment4.1 written exam 100

5 -- List of References5.1- Course Notes (paper and / or electronic)

5.2- Essential Books (Text Books)Jawetz, Melnick and Adelberg’s Medical Microbiology5.3- Recommended Books

5.4- Periodicals, Web Sites, etchttp://www.phage.org/black09.htmhttp://www.microbe.org/microbes/virus_or_bacterium.asphttp://www.bact.wisc.edu/Bact330/330Lecturetopicshttp://whyfiles.org/012mad_cow/7.htmlhttp://www.microbelibrary.org/http://www.hepnet.com/hepb.htm

23

http://www.tulane.edu/~dmsander/Big_Virology/BVHomePage.htmlhttp://www.mic.ki.se/Diseases/c2.htmlhttp://www.med.sc.edu:85/book/welcome.htmhttp://www.biology.arizona.edu/immunology/microbiology_immunology.html

D. Molecular biology course specification University: Ain Shams University Faculty: of MedicineCourse specificationsProgram on which the course is given: Doctorate of Science in Histology.Major or minor element of programs: Minor Department offering the program: Histology department.Department offering the course: Medical biochemistry and Molecular biology departmentAcademic Level: Doctorate at any semester. Date of specification approval: …………………………..

A- Basic InformationTitle: Molecular biology course Code: E7012Credit Hours: 2 hours Lecture: 2hs/week Total: 30hs

CoordinatorMedical biochemistry and Molecular biology department

B - Professional Information1- Course Aims:By the end of the course the candidate will be able to:a) Gain a thorough understanding of the basic principles of molecular biology. b) Understand the tools of DNA technology. c) Read and interpret scientific papers. d) Design approaches to addressing questions in molecular biology e) Understand the applications of molecular biology in rheumatology.

2- Intended Learning Outcomes (ILOs) from the Course:a- Knowledge and understandingBy the end of the course the candidate will be able to:a1 - Describe the chemistry of nucleotides and nucleic acids.a2 - Point out the processes of replication, transcription and translation.a3 - Describe recombinant DNA biotechniques.a4 - Describe the structure of heme and uric acid metabolism. a5 - Describe the structure of collagen and collagen metabolism.

24

b- Intellectual skillsBy the end of the course the candidate will be able to: b1 - Select the proper investigation for rheumatic diseases.b2 - Read and evaluate scientific literature in the molecular biology sciences.

c- Professional skillsBy the end of the course the candidate will be able to:c1- Recognize basic principle of DNA extractionc2 - Be aware of further techniques using the extracted DNA.c3- Read and evaluate scientific literature in the molecular biology sciences.

d- General and transferable skills By the end of the course the candidate will be able to:d1 - Work effectively in a group during preparation of seminars. d2- Respects the role of staff and co-staff members regardless of degree or occupation.

3- Course content:Topics No. of hours

L T C/P SDLBasic DNA structure 2

DNA replication 2DNA repair 2Transcription and post transcription

2

Protein synthesis (Translation ) 2Post translation processing 2

Techniques PCR (Applications of polymerase chain reaction in rheumatology)

4

Blotting (western, southern and northen)

2

Recombinant technique 2Special topics Apoptosis 3

Angiogenesis 2Tolerance 2

25

Collagen metabolism 32

L: Lecture, T: Tutorial, C/P: Clinical or Practical and SDL: Self directed learning4 - Student Assessment Methods4.1written exam to assess knowledge and understandingWeighing of assessment4.1 written exam 100Total 1005 -- List of References5.1- Course Notes (paper and / or electronic)Electronic lectures5.2- Essential Books (Text Books)Lecture notes on molecular medicine5.3- Recommended Books………………………………………5.4- Periodicals, Web Sites, etchttp://www.web-books.com/MoBio/http://www.coe.uncc.edu/~hhilger/EB_I_F_06/web_links_on_basics_of_molecular_biology.htm

Basicshttp://plato.acadiau.ca/courses/biol/Microbiology/Basics.htm

Cell structurehttp://www.wiley.com/legacy/college/boyer/0470003790/animations/cell_structure/cell_structure.htmhttp://www.cellsalive.com/cells/3dcell.htm

DNAhttp://www.pbs.org/wgbh/nova/genome/dna.html#http://www.johnkyrk.com/DNAanatomy.html good linkhttp://www.pwc.k12.nf.ca/wadey/biotech/dna1.swf

Replicationhttp://www.johnkyrk.com/DNAreplication.htmlhttp://highered.mcgraw-hill.com/sites/0072437316/student_view0/chapter14/animations.html#http://www.wiley.com/college/pratt/0471393878/student/animations/dna_replication/index.html

26

http://www.wiley.com/college/pratt/0471393878/student/animations/dna_replication/index.html

http://www.wiley.com/college/pratt/0471393878/student/animations/dna_replication/index.html

http://highered.mcgraw-hill.com/sites/0072437316/student_view0/chapter14/animations.html


http://www.johnkyrk.com/DNAreplication.html

http://www.pwc.k12.nf.ca/wadey/biotech/dna1.swf

http://www.johnkyrk.com/DNAanatomy.html

http://www.pbs.org/wgbh/nova/genome/dna.html

http://www.cellsalive.com/cells/3dcell.htm

http://www.wiley.com/legacy/college/boyer/0470003790/animations/cell_structure/cell_structure.htm

http://www.wiley.com/legacy/college/boyer/0470003790/animations/cell_structure/cell_structure.htm

http://plato.acadiau.ca/courses/biol/Microbiology/Basics.htm

http://www.coe.uncc.edu/~hhilger/EB_I_F_06/web_links_on_basics_of_molecular_biology.htm

http://www.coe.uncc.edu/~hhilger/EB_I_F_06/web_links_on_basics_of_molecular_biology.htm

http://www.web-books.com/MoBio/

Transcriptionhttp://www.johnkyrk.com/DNAtranscription.html very good link Protein synthesishttp://www.johnkyrk.com/DNAtranslation.html very good linkhttp://www.wisc-online.com/objects/index_tj.asp?objid=AP1302http://highered.mcgraw-hill.com/sites/0072437316/student_view0/chapter15/animations.htmlhttp://learn.genetics.utah.edu/units/basics/transcribe/ http://library.thinkquest.org/20465/g_DNATranscription.htmlhttp://www.brookscole.com/chemistry_d/templates/student_resources/shared_resources/animations/protein_synthesis/protein_synthesis.htmlhttp://www.biostudio.com/demo_freeman_protein_synthesis.htm

Beginner’s guide to molecular biologyhttp://www.rothamsted.ac.uk/notebook/courses/guide/http://publications.nigms.nih.gov/insidethecell/chapter1.htmlhttp://www.cs.washington.edu/homes/tompa/papers/molbio.pdfhttp://en.wikipedia.org/wiki/Central_dogma_of_molecular_biologyhttp://en.wikipedia.org/wiki/Molecular_biology

PCRhttp://www.escience.ws/b572/L3/L3.htmhttp://www.bio.com/protocolstools/protocol.jhtml?id=p1242 http://users.ugent.be/~avierstr/principles/pcr.html http://depts.washington.edu/genetics/courses/genet371b-aut99/PCR_contents.html [animation]http://www.sumanasinc.com/webcontent/anisamples/molecularbiology/pcr.html [animation]

Southern blothttp://www.accessexcellence.org/RC/VL/GG/southBlotg.htmlhttp://highered.mcgraw-hill.com/olcweb/cgi/pluginpop.cgi?it=swf::535::535::/sites/dl/free/0072437316/120078/bio_g.swf::Southern%20Blot

Northern blothttp://www.ambion.com/techlib/basics/northerns/index.html http://homepages.strath.ac.uk/~dfs99109/BB211/RecombDNAtechlect2.html#southerns

Western blothttp://www.bme.gatech.edu/vcl/WesternBlotting/Background/Introduction.htm

27

http://www.bme.gatech.edu/vcl/WesternBlotting/Background/Introduction.htm

http://homepages.strath.ac.uk/~dfs99109/BB211/RecombDNAtechlect2.html#southerns

http://homepages.strath.ac.uk/~dfs99109/BB211/RecombDNAtechlect2.html#southerns

http://www.ambion.com/techlib/basics/northerns/index.html

http://highered.mcgraw-hill.com/olcweb/cgi/pluginpop.cgi?it=swf::535::535::/sites/dl/free/0072437316/120078/bio_g.swf::Southern%20Blot

http://highered.mcgraw-hill.com/olcweb/cgi/pluginpop.cgi?it=swf::535::535::/sites/dl/free/0072437316/120078/bio_g.swf::Southern%20Blot

http://www.accessexcellence.org/RC/VL/GG/southBlotg.html

http://www.sumanasinc.com/webcontent/anisamples/molecularbiology/pcr.html

http://depts.washington.edu/genetics/courses/genet371b-aut99/PCR_contents.html%20%5Banimation%255d

http://users.ugent.be/~avierstr/principles/pcr.html

http://www.bio.com/protocolstools/protocol.jhtml?id=p1242

http://www.escience.ws/b572/L3/L3.htm

http://en.wikipedia.org/wiki/Molecular_biology

http://en.wikipedia.org/wiki/Central_dogma_of_molecular_biology

http://www.cs.washington.edu/homes/tompa/papers/molbio.pdf

http://publications.nigms.nih.gov/insidethecell/chapter1.html

http://www.rothamsted.ac.uk/notebook/courses/guide/

http://www.biostudio.com/demo_freeman_protein_synthesis.htm

http://www.brookscole.com/chemistry_d/templates/student_resources/shared_resources/animations/protein_synthesis/protein_synthesis.html

http://www.brookscole.com/chemistry_d/templates/student_resources/shared_resources/animations/protein_synthesis/protein_synthesis.html

http://library.thinkquest.org/20465/g_DNATranscription.html

http://learn.genetics.utah.edu/units/basics/transcribe/



http://www.wisc-online.com/objects/index_tj.asp?objid=AP1302

http://www.google.com/url?sa=D&q=http%3A%2F%2Fwww.johnkyrk.com%2FDNAtranslation.html

http://www.johnkyrk.com/DNAtranscription.html

http://www.bio.davidson.edu/courses/genomics/method/Westernblot.htmlhttp://www.westernblotting.org/

Animated Techniques:http://www.sumanasinc.com/webcontent/anisamples/molecularbiology/molecularbiology.html

V- General Information

1 – Monitoring Of Training and Submission Of Training ReportsYou must keep proper and updated records in your logbook to reflect the activities encountered in your training. Your logbook must be duly endorsed by an authorized signatory at the end of each semester.You will be continuously assessed by your supervisors, in consultation with head of department. An assessment will be submitted within 2 weeks of completion of each semester.

2 - Miscellaneous Information:

Injury and/or Blood or Body Fluid Exposure: During regular working hours, you should immediately report an exposure incident to any harmful chemical. If exposure occurs after regular working hours or during a weekend or holiday; please call the Toxicology Unit at Ain Shams Hospital. For injury, please report to the Emergency Department. Please also be sure to inform the supervisors of an exposure incident and/or injury.

3 - Action Completion Of Clinical TrainingOnce all training sessions are completed the log book should be signed by the senior supervisor and the head of the department and then should be submitted to post graduate Secretariat.

4- ReferenceThe Training Guide is available at the post graduate Secretariat.

---------------------------------------------------------------

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http://www.sumanasinc.com/webcontent/anisamples/molecularbiology/molecularbiology.html

http://www.sumanasinc.com/webcontent/anisamples/molecularbiology/molecularbiology.html

http://www.westernblotting.org/

http://www.bio.davidson.edu/courses/genomics/method/Westernblot.html

VI – Your log book

1- IntroductionThe aim of this book is to give you a guide to the expectations for each item. It will be a guide for both you and your teachers to what you should be seeing and doing.

It will give you a list of the important topics that you should think about and should be covered in:1. Practical sessions.or2. Tutorialsor3. Self-directed learning (SDL)For each item there is also a list of1. Practical sessions to be seen or attended.2. Practical procedures to be seen and doneRemember

This document is only a guide. It is not an exhaustive list. It is not just a checklist to score points. It is a guide to encourage you to read and learn more. This book is for your benefit. It will form a record of your clinical training and experience.

2 - Supervisors ………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………3–Tables for Training Records

29

Candidates are required to fulfill 75% of the listed activities in order to be eligible for the exam entry. The minimum number required for each activity = 75%. You are free to attend more and record your extra attendance.

Weekly Department Plan

Day /time

Saturday

Sunday

Monday

Tuesday

Wednesday

Thursday

lectures 8-10Group discussion

11.30-1.30

Slide training

11.30-1.30

3-5

Slide prepration

10-11.303-4.30

Prelab. teaching

كل حسب جدوله

Monthly activity: SeminarsSixth monthly activity: researchesYearly activity: conferences.

Conferences attendance(NB. Minimum number required is 6)

No

Dat

e

Plac

e

Annual conference of Histology

Annual conference of

Faculty of Medicine, Ain

Shams University

Supervisor

signature

Seminars attendance(NB. Minimum number required is 12)

No Date Place Topics Supervisor

30

signature

Thesis attendance(NB. Minimum number required is10)

No Date Place Name of the thesis Supervisor signature

Tutorials Attended(NB. Minimum number required is 12/course)

No Date Place Name of the tutorial Supervisor signature

31

Teaching Prelabs (NB. Minimum number required is 10 (present 3 models of a lecture

No Date Place Name Supervisor signature

Interactive learning (present an updated subject or technique)(NB. Minimum number required is 1/semester)

No Date Primary diagnosis Supervisor signature

Practical skills (Agreement Scale)RequirementsCandidates are required to fulfill 75% of the listed activities in order to be eligible for the exam entry. The minimum number required for each activity = 75%. You are free to attend more and record your extra attendance.

32

Item No

Obs

erve

d

Dat

e

assi

sted

Dat

e

Don

e in

depe

nden

tly(A

, B, C

)A

ccor

ding

to e

ach

depa

rtmen

t

Dat

e

Supe

rvis

or si

gnat

ure

Special staining techniques: Silver Stain for eleastic fs Stain for collagen Histochemistry

10101010

Advanced techniques (two are recommended):-ultrathin resin -Ulrathinmicrotome –immunohistochemistry-Immage analyzer

22

a- Poor b- Satisfactory c- Excellent

5 - Log book preview

The candidate logbook will be reviewed and patients seen/ skills performed summarized by diagnosis groups during the semester evaluation and at the end of the course in the table below. The results of this review will be totaled in the summary chart below.

SummarySemester 1st 2nd 3rd 4th 5th 6th TotalActivity No No No No No NoConference attendanceSeminars attendanceThesis attendanceTutorials attendanceTeaching pre-labsInteractive learningPractical skillsSupervisor signature

33

VII - Head Of Department Approval For The Exam Entry__________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________

34

35

VIII – Thesis Follow up

/ التاريخ / لعام السنوى النصف التقريرالطالب / عن

ماجسيتر ( ) لدرجة المقيدبقسم /

المشرفين االساتذة السادة تقرير

و العلمية المادة جمعالمقدمة كتابة

شوطا بدأ قطعمحدودا

على أوشكاإلنتهاء

من إنتهىالجمع

العملى شوطا بدأالجزء قطعمحدودا


من إنتهىالتحليل

النتائج شوطا بدأمناقشة قطعمحدودا


من إنتهىالتحرير

مع النهائية المراجعةالمشرف



تماما إنتهت

السادة رأىالمشرفين

قيد إستمرارالطالب

القيد مد

قيد شطب الطالب

لجنة تشكيل تمالمناقشة

نعم ال

تاريخ التشكيل

/ /

القيد / شطب مدالمشرفين السادة الكلية توقيع وكيل

36

37




















القيد مد

قيد شطب

38

الطالب


نعم ال


/ /


39
















40





القيد مد



نعم ال


/ /


41











42










القيد مد



نعم ال


/ /


43






44















القيد مد



نعم ال


/ /


45

46




















القيد مد



نعم ال


/ /

القيد / شطب مد

47

المشرفين السادة الكلية توقيع وكيل

48

VIII – Evaluation Forms

To be completed at -------------------------------------

Candidate SupervisorLocation

Aim of training ______________________________________________________________________________________________________________________________________________________________________________________________________ Agreed educational objectives and timescale in which objectives should be achieved. ______________________________________________________________________________________________________________________________________________________________________________________________________

Comments by Candidate____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________

Comments by Supervisor ____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________

49

__________________________________________________________________

Date of next meeting Signed by candidateSigned by Supervisor Date

50







51

__________________________________________________________________


52







53

__________________________________________________________________


54







55

__________________________________________________________________


56







57

__________________________________________________________________


58







59

__________________________________________________________________


60

Degree Program Evaluation Form by The CandidateTo be completed at the end of your degree.

Please consider each pair of statements and decide which most clearly reflects your view and tick one box or answer the question.

I. Individual Information1. Are you a graduate of ASU?

yes no to some degree2. Year and semester when studies began:

II. General Questions1. What are the advantages/disadvantages of the general study environment at the University ASU?

2. What were your expectations when you applied to the degree?

3. Do you feel that the degree program prepares you well for your future studies or employment according to the demands and expectations of those institutions?

yes no to some degree

4. Has the time limit of the program (two or three academic years) caused you any difficulties or inconveniences?


III. Structure of Degree Program

61

1. Did you receive enough guidance in planning your study schedule in the beginning of the program?


2. What were the main difficulties in the planning of your study schedule?

3. What is your general opinion on the structure of the degree program?

4. In your opinion, does the degree program offer a good balance of lectures, seminars, conferences, and book exams?


a) General Studies

i) Do you feel that you have received enough guidance on academic writing?


ii) Do you feel that you have acquired sufficient knowledge on research skills (eg. quantitative and qualitative research methods)?


b) Courses i) Have you had some special difficulties in completing some of the courses? Please specify.

ii) Has there been a sufficient variety of courses offered for your optional studies?


iii) Have you received enough guidance for the preparation of your thesis?


IV. Concluding Points1. Did the degree program meet your expectations?


62

2. What aspects of the degree program do you particularly like?

3. What aspects of the degree program do you particularly dislike?

4. What are your suggestions on how to improve the program?

Thank you!

63

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