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Contents

Now Available and Forthcoming ..........................3

New and Bestselling Textbooks ............................6

Imaging in Medical Diagnosis and Therapy Series ....................................................10

New and Bestselling References ........................16

Biomedical Optics ..............................................20

Image Processing and Informatics ......................22

Also of Interest ....................................................25

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Now Available and Forthcoming

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New!

EmergingImagingTechnologies inMedicineEdited by

Mark A. AnastasioWashington University, St. Louis,Missouri, USA

Patrick La RiviereUniversity of Chicago, Illinois, USA

This book offers a comprehensive survey of emergingmedical imaging technologies that show great prom-ise for routine clinical use. Each chapter provides adetailed discussion of the physics/technology andaddresses improvements in terms of dose, sensitivity,and specificity, which are limitations of current imag-ing approaches. The book reflects the major advancesin computer hardware, nanofabrication, and lasertechnology that have led to developments in phase-contrast imaging, photoacoustic imaging, and opticalimaging.

• Provides an overview of the most importantemerging medical imaging technologies, modal-ities, and clinical applications

• Covers tomosynthesis, breast CT, spectral CT, x-ray phase-contrast imaging, photoacoustic imag-ing, diffuse optical tomography, and acousticimaging

• Presents an overview of the modality, a summa-ry of clinical potential, and a detailed discussionof the physics and technology

• Emphasizes a clear understanding of the funda-mentals, with a focus on hardware develop-ments

• Discusses multimodality imaging, includingPET/MRI, diffuse optical tomography/MRI, andphotoacoustic tomography/diffuse opticaltomography

• Explores three-dimensional microscopy, such asphotoacoustic microscopy, optical coherencetomography, and Fourier transform infraredspectroscopy

Selected Contents:

Advancements in Absorption-Based X-Ray Imaging.X-Ray Phase-Contrast Imaging. PhotoacousticImaging and Tomography. Diffuse Optical Imaging.Advances in Acoustical Imaging. MultimodalityImaging. Recent Advancements in Three-Dimensional Microscopy.

Catalog no. K13780, December 2012, 361 pp.ISBN: 978-1-4398-8041-8, $169.95 / £108.00Also available as an eBook

Webb’s Physicsof MedicalImagingSecond EditionEdited by

M A FlowerInstitute of CancerResearch/Royal Marsden NHSFoundation Trust, UK

“Possibly the most comprehensive book on the sub-ject currently on the market.”

—Sandro Olivo, University College London

Gathering recent developments into one volume, thiscomprehensive second edition presents the basicphysics, modern technology, and up-to-date exam-ples of clinical application across all the modalities ofmedical imaging. It now covers state-of-the-art detec-tor technology and computer processing used inmedical imaging. Along with many new examplesand figures, this edition includes new chapters onmedical image processing and multimodality imag-ing.

• Presents the essential physics of medical imaging

• Covers each imaging modality in detail, elimi-nating the need to consult specialized texts

• Provides many examples of clinical applicationsof medical imaging

• Includes contributions from leading researchersand clinical scientists

• Contains more than 400 high-quality figures,with some in color

Selected Contents:

In the Beginning: The Origins of Medical Imaging.Diagnostic Radiology with X-Rays. X-RayTransmission Computed Tomography. ClinicalApplications of X-Ray Computed Tomography inRadiotherapy Planning. Radioisotope Imaging.Diagnostic Ultrasound. Spatially Localised MagneticResonance. Physical Aspects of Infrared Imaging.Imaging of Tissue Electrical Impedance. OpticalImaging. Mathematics of Image Formation andImage Processing. Medical Image Processing.Perception and Interpretation of Images. ComputerRequirements of Imaging Systems. MultimodalityImaging. Epilogue. Index.

Catalog no. IP743, June 2012, 864 pp.ISBN: 978-0-7503-0573-0, $89.95 / £49.99Also available as an eBook



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New!

Monte CarloTechniques inRadiationTherapyEdited by

Joao SecoMassachusetts General Hospital,Boston, USA

Frank VerhaegenMaastro Clinic, Maastricht, Netherlands

This book explores the use of Monte Carlo methodsfor modeling various features of internal and externalradiation sources. It addresses applications of theMonte Carlo particle transport simulation techniquein radiation therapy, mainly focusing on externalbeam radiotherapy and brachytherapy. Along withpresenting mathematical and technical aspects of themethods, the book discusses the modeling of medicallinacs and other irradiation devices; issues specific toelectron, photon, and proton ion beams andbrachytherapy; and the optimization of treatmentplanning, radiation dosimetry, and quality assurance.

• Provides a broad practical guide to the rapidlygrowing field of Monte Carlo simulations used inmedical physics in radiotherapy

• Includes the mathematical and technical back-ground required for understanding Monte Carlosimulations and variance reduction techniques

• Covers real medical applications of Monte Carlomethods in proton/light ion therapeutics, beammodels, quality assurance, radiation dosimetry,and patient dose calculation

• Incorporates examples to help illustrate keypoints

Selected Contents:

Monte Carlo Fundamentals: History of MonteCarlo. Basics of Monte Carlo Simulations. VarianceReduction Techniques. Overview of Monte CarloCodes. Application of Monte Carlo Techniques inRadiation Therapy: Applications of Monte Carlo toRadiation Dosimetry. Monte Carlo Modeling ofExternal Photon Beams in Radiotherapy. Monte CarloModeling of External Electron Beams inRadiotherapy. Dynamic Beam Delivery and 4DMonte Carlo. … Index.

Catalog no. K14687, March 2013, 342 pp.ISBN: 978-1-4665-0792-0, $149.95 / £95.00Also available as an eBook

Coming soon!

Handbook ofPhotomedicineEdited by

Michael R. HamblinHarvard Medical School, Boston,Massachusetts, USA

Ying-Ying HuangWellman Center forPhotomedicine, Boston,Massachusetts, USA

This handbook thoroughly covers both therapeuticapplications of light and diseases/conditions causedby light exposure. It also discusses the underlying cel-lular mechanisms and molecular synthesis of photo-sensitizer dyes used in phototherapy. An introductorysection provides the necessary background for new-comers to the field, briefly tracing the history of thefield and summarizing fundamental principles. Eachsubsequent section addresses a major subject of thefield, including UV/PVA phototherapy, photodynamictherapy, laser surgery and medicine, and low-levellaser/light therapy. Along with many examples, thebook offers expert views on the state of the art andchallenges in photomedicine.

• Supplies a complete overview of the state of theart in photomedicine, from basic science totranslational research and clinical treatment

• Examines the diseases and conditions associatedwith UV/PVA phototherapy, photodynamic ther-apy, laser surgery and medicine, and low-levellaser/light therapy

• Takes an interdisciplinary approach by integrat-ing knowledge and techniques from chemistry,physics, engineering, the biological sciences,and clinical medicine

• Addresses photocarcinogenesis, photoder-matoses, photoallergies, and photoaging

• Explores timely topics related sunscreens and cli-mate change-associated UV exposure

Selected Contents:

History and Fundamentals. Diseases Caused by Light.Ultraviolet Phototherapy. Photodynamic Therapy(PDT). Low-Level Light Therapy (LLLT). Surgical LaserTherapy. Other Phototherapy and Future Outlook.

Catalog no. K13978, October 2013, c. 904 pp.ISBN: 978-1-4398-8469-0, $199.95 / £127.00Also available as an eBook



5



Coming soon!

ImageProcessing inRadiationTherapyEdited by

Kristy K. BrockUniversity of Michigan, AnnArbor, USA

Drawing on expert assessments and practical refer-ences, this book provides complete descriptions of thetechniques involved in medical image processing.Chapters cover deformable registration, segmenta-tion, and image reconstruction, along with the inte-gration of these practices into the radiation therapyenvironment.

The book’s four sections provide an overview of imagesegmentation and reconstruction techniques usingimage processing across all modalities as well as appli-cations of these approaches in radiation therapy. Thebook also addresses the applications of registration,segmentation, and image reconstruction for radiationtherapy, including adaptive radiotherapy, monitoringand tracking of treatment delivery, quantifying accu-racy, and visualizing results.

• Offers a complete overview of image registra-tion, segmentation, and reconstruction tech-niques as well as their effectiveness and applica-bility in a radiation therapy context

• Covers the underlying physics and image pro-cessing associated with the techniques

• Includes critical evaluations of parametric andnonparametric image registration techniquesand their applications in radiation therapyprocesses

• Covers image segmentation techniques, fromatlas-based to level set and registration-basedtechniques across modalities

• Discusses adaptive radiotherapy, monitoring andtracking of treatment delivery, quantifying accu-racy, and visualizing results

Selected Contents:

Image Processing in Radiotherapy Applications.Registration. Segmentation. Advanced ImagingTechniques.

Catalog no. K11476, August 2013, c. 312 pp.ISBN: 978-1-4398-3017-8, $129.95 / £82.00Also available as an eBook

New!

PediatricRadiotherapyPlanning andTreatmentArthur J. OlchChildren’s Hospital Los Angeles,California, USA

This practical guide covers every common diagnosisand disease site for infants through to teenagers. Itpresents clinical background information on pediatriccancers and a detailed discussion of treatment plan-ning guidelines and methods. The author provides anoverview of pediatric cancer and addresses specificissues that make treating children a challenge. Thebook also describes clinical trial guidelines andincludes examples, CT scans, MRI images, tables, andfigures.

• Offers a concise and easy-to-use guide for treat-ing pediatric cancers using radiation, with anemphasis on how to create and optimize treat-ment plans and accurate execution

• Provides a much-needed bridge between clinicalmaterial specific to pediatrics and technicalmaterial specific to adults

• Covers both IMRT and 3D conformal methods

• Includes real example cases with anatomicaldrawings and CT/MR images as well as figuresthat show target and organs-at-risk volumes,beam arrangements, and dosimetry

• Describes the use of advanced technologies,including proton beam therapy, cyberknife, andimage-guided radiotherapy

• Discusses special considerations for pediatriccare, immobilization devices, and tips for under-taking clinical trials

Selected Contents:

Section I Pediatric Cancers and Challenges forRadiotherapy: Overview of Childhood Cancer:Incidence, Survival, and Late Effects. Challenges ofTreating Children with Radiation Therapy. Section II Guide to Treatment Planning and DoseDelivery: Leukemia. Tumors of the Central NervousSystem. Hodgkin Lymphoma. Neuroblastoma.Wilms’ Tumor. Soft Tissue Tumors. Bone Sarcomas.Retinoblastoma.

Catalog no. 85093, April 2013, c. 376 pp.ISBN: 978-1-4200-8509-9, $149.95 / £95.00Also available as an eBook




New and Bestselling Textbooks

Coming soon!

Clark’s Essential Physics inImaging forRadiographersKen Holmes, Phil Harris,and Marcus ElkingtonAn invaluable tool for students, assistant practitioners,and radiographers, this easy-to-understand, handybook provides an accessible guide to the subject, withdiagrams and photographs to support the text. Thetext opens with chapters giving an overview of imageproduction, basic mathematics, and physics relevantto medical imaging, followed by detailed chapters onthe physics relevant to producing diagnostic imagesusing x-rays. Each chapter has clear learning objec-tives and a series of MCQs to test these learning out-comes.

• Offers a practical guide for the study of physicsin imaging for radiographers

• Presents clear explanations supplemented withmany diagrams and photographs

• Enables readers to understand fundamental defi-nitions of physics and how these are applied toradiography

• Makes a difficult subject easy by offering learn-ing objectives at the beginning of each chapteras well as MCQs and challenging questions totest learning outcomes at the end of each chap-ter

Selected Contents:

Overview of Image Production. Mathematics forMedical Imaging. Physics for Medical Imaging. X-Rays, X-Ray Circuit, and X-Ray Tube. X-RayInteractions. Principles of Radiation Detection andImage Formation. Image Quality. Radiation Dose andExposure Indicators. Image Display and Manipulationin Medical Imaging. Radiation Protection and Safety.Risk–Benefit.

Catalog no. K18088, June 2013, 320 pp.Soft Cover, ISBN: 978-1-4441-4561-8$31.95 / £19.99

Measurementand Detectionof RadiationThird EditionNicholas TsoulfanidisUniversity of Nevada, Reno, USA

Sheldon LandsbergerUniversity of Texas at Austin,USA

“… a very good textbook, providing a solid intro-duction to radiation detection and measurement forupper-level undergraduate and first-year graduatestudents in the field of nuclear science and engineer-ing.”

—Medical Physics, July 2012

“… a good background reference [for] those inter-ested in a refresher course in the physics underlyingdetection. …”—Olivier Gayou, Doody’s Listings and Reviews, August 2011

“This book is an excellent review of nuclear detectionsystems. The updated text is particularly timely withregard to the current zeitgeist for homeland security,nuclear non-proliferation, and nuclear security.”

—Steven Biegalski, University of Texas at Austin

Continuing in the tradition of its bestselling predeces-sors, this third edition illustrates the fundamentals ofnuclear interactions and radiation detection with amultitude of examples and problems. This editionincludes a new chapter on recent applications of radi-ation detection, updated topics, many new refer-ences, and a completely updated bibliography.

Selected Contents:

Introduction to Radiation Measurements. StatisticalErrors of Radiation Counting. Review of Atomic andNuclear Physics. Energy Loss and Penetration ofRadiation through Matter. Gas-Filled Detectors.Scintillation Detectors. Semiconductor Detectors.Relative and Absolute Measurements. Introduction toSpectroscopy. Electronics. Data Analysis Methods.Photon (Gamma-Ray and X-Ray) Spectroscopy.Charged-Particle Spectroscopy. Neutron Detectionand Spectroscopy. Activation Analysis. Health PhysicsFundamentals. Applications of Radiation Detection.Appendices. Index.

Catalog no. 91859, December 2010, 518 pp.ISBN: 978-1-4200-9185-4, $145.95 / £93.00Also available as an eBook



7



Applied Medical ImageProcessingA Basic CourseWolfgang BirkfellnerMedical University of Vienna,Austria

“The topics covered are clearly explained … an idealtext for anyone who is new to medical image pro-cessing. … This text is likely to be of interest to stu-dents starting work in medical image processing andwould be a useful library text for hospital depart-ments offering training in medical imaging.”

—Sarah Cade, Scope, December 2011

“The CD adds substantial value to the text andserves as an excellent guide to practice the informa-tion covered in the text. … Several books on imageprocessing have been published recently, and thisbook takes a backseat to none of them. … Studentswho take a course where this book is used as thecourse text will be fortunate indeed.”

—William Hendee, Medical Physics, December 2010

“[A]n outstanding work that will be of interest to vir-tually all biomedical engineers. The text is easy tofollow, supposing only that the reader has a modestknowledge of linear algebra, basic engineering prin-ciples, and computer programming. … Relevantmedical images used for processing complimentmany of the concepts discussed. … The text andimages refer to several MATLAB®-based program-ming examples that are provided at the end of eachchapter. … The book is enjoyable to read, and stu-dents and professionals will not be bored whendoing so. …”

—Edward J. Ciaccio, BioMedical Engineering OnLine, 2011

Selected Contents:

A Few Basics of Medical Image Sources. ImageRepresentation. Operations in Intensity Space.Segmentation. Filtering and Transformations. SpatialTransforms. Rendering, Visualization, and SurfaceModels. Registration. Volume Reconstruction.Appendix. Glossary. Index.

Catalog no. K11176, September 2010, 403 pp.ISBN: 978-1-4398-2444-3, $76.95 / £48.99Also available as an eBook

Physics forDiagnosticRadiologyThird EditionP.P. DendyAddenbrookes NHS Trust,Cambridge, UK

B. HeatonAberdeen Radiation ProtectionServices, UK

“… written in a clear and concise style, supported byexcellent illustrations. The textbook describes recentstate-of-the-art advances in medical imaging in away radiologists, radiographers and medical physi-cists will find easy to understand. It is international-ly recognised as one of the key textbooks in its field.”

—Keith Faulkner, North East Strategic Health Authority, UK

• Explains the underlying physical principles ofimaging techniques

• Includes new chapters on PET and PACS

• Offers new material on digital receptors, radia-tion doses and risks to patients, and special radi-ographic techniques

• Points out the similarities of concepts across dif-ferent modalities

• Follows the guidelines issued by the EuropeanFederation of Organisations in Medical Physicsfor training in diagnostic radiology

• Contains exercises and multiple choice questionsfor readers to assess their understanding of thebasic principles

• Includes extensive cross-referencing, text refer-ences, and recommendations for further reading

Selected Contents:

Fundamentals of Radiation Physics and Radioactivity.Production of X-Rays. Interaction of X-Rays andGamma Rays with Matter. Radiation Measurement.The Image Receptor. The Radiological Image.Assessment of Image Quality and Optimisation.Tomographic Imaging with X-Rays. SpecialRadiographic Techniques. Diagnostic Imaging withRadioactive Materials. Positron EmissionTomographic Imaging (PET). Radiobiology andGeneric Radiation Risks. Radiation Doses and Risks toPatients. Practical Radiation Protection andLegislation. Diagnostic Ultrasound. MagneticResonance Imaging. Digital Image Storage andHandling. Multiple Choice Questions. Index.

Catalog no. 83155, August 2011, 720 pp.ISBN: 978-1-4200-8315-6, $79.95 / £49.99Also available as an eBook





Introduction to Physics in ModernMedicineSecond EditionSuzanne Amador KaneHaverford College, Pennsylvania,USA

“… textbooks introducing this topic to students fromnon-scientific backgrounds need to present the fun-damental theory in a manner that is easily graspedyet sufficiently in depth to enable the reader toappreciate its application to real problems.Introduction to Physics in Modern Medicinemanages to tread this fine line admirably. … Tomake this second edition up to date, the authordescribes a number of recent advances … the con-tents are thoroughly grounded in well-explainedpractical examples. … [a] well-researched book thatrenders complex subject matter thoroughly under-standable and enjoyable.”

—Contemporary Physics, 2011

Fully updated, this second edition builds on the best-selling original to provide medical and physics stu-dents with an exploration of the physics-related appli-cations found in state-of-the-art medical centers.Requiring very little physics, biology, or chemistry andkeeping mathematics to a minimum, the applications-dedicated chapters adhere to simple and self-con-tained qualitative explanations that make use ofexamples and illustrations. With an enhanced empha-sis on digital imaging and computers in medicine, thisedition gives readers a fundamental understanding ofstate-of-the-art medical physics as well as theadvances, technologies, and practical applications ofdigital imaging. The text includes case studies,worked examples, and exercises. Supporting materialis available on the author’s website.

Selected Contents:

Introduction and Overview. Telescopes for InnerSpace. Lasers in Medicine. Seeing with Sound. X-RayVision. Images from Radioactivity. Radiation Therapyand Radiation Safety in Medicine. MagneticResonance Imaging.

Catalog no. C9438, April 2009, 448 pp.Soft Cover, ISBN: 978-1-58488-943-4$62.95 / £39.99Also available as an eBook

NuclearMedicinePhysicsEdited by

Joao Jose De LimaIBILI Biophysics Institute,Coimbra, Portugal

“The data contained here will no doubt prove vitalto researchers in multiple disciplines (physics,nuclear medicine, oncology) looking for ways toexpand and upgrade patient care, specifically,oncologists charged with diagnosing and treatingvarious forms of cancer will immediately benefitfrom learning how nuclear imaging techniques canenhance the patient experience in the clinical set-ting.”

—The Electric Review, January 2011

Edited by a renowned international expert in the field,this work explores the physics behind the theoreticalfoundation and applications of nuclear medicine. Itcovers important physical aspects of the methods andinstruments involved in modern nuclear medicine,along with related biological topics. The book dis-cusses the production of radioisotopes and radiophar-maceuticals, positron physics and positron applica-tions in medicine and biology, and modern radiationdetectors and measuring methods. It also exploressystems in nuclear medicine, imaging methodologies,dosimetry, and the biological effects of radiation.

• Discusses topics useful in nuclear medicine R&Dand clinical applications

• Covers subjects not frequently discussed innuclear medicine books, such as acceleratorsand positron physics

• Describes the production of radioisotopes andthe biological effects of radiation

• Presents novel physical approaches relating toradiopharmaceuticals and their use

Selected Contents:

Introduction. Radioisotopes andRadiopharmaceuticals Production. Positron Physics:Applications in Medicine and Biology. ModernRadiation Detectors and Measuring Methods.Systems in Nuclear Medicine. ImagingMethodologies. Dosimetry and Biological Effects ofRadiation. Index.

Catalog no. C7958, November 2010, 524 pp.ISBN: 978-1-58488-795-9, $167.95 / £107.00Also available as an eBook



9



Physiology,Biophysics andBiomedicalEngineeringEdited by

Andrew W. WoodSwinburne University ofTechnology, Hawthorn, Victoria,Australia

Showing how biophysics and biomedical engineeringhave advanced modern medicine, this text provides amultidisciplinary understanding of biological phe-nomena and the instrumentation for monitoringthese phenomena. It explores the application ofphysics and engineering methods to medicine andbiology, including the use of nanotechnology in bio-medical engineering.

• Offers a multidisciplinary approach to humanbiological systems

• Highlights the application of physics and engi-neering methods to medicine and biology

• Gives readers a solid basis for understanding thephysiological processes in the human body

• Draws on the classroom material of experiencedlecturers

• Incorporates a range of numerical problems withworked solutions

• Provides MATLAB® code for the advanced math-ematical analysis of physiological and clinicalmonitoring systems

Selected Contents:

INTRODUCTION. MAINLY MOLECULES: MolecularBiophysics. Membrane Biophysics. Excitability andSynapses. Skeletal Muscle Biophysics. HEART ANDCIRCULATION: Cardiac Biophysics. Rheology ofBlood. The Vascular System: Blood Flow Patterns inVarious Parts of the Circulation. CardiovascularSystem Monitoring. LUNGS, KIDNEYS, AND SPECIALMONITORING: Respiratory Biophysics. RenalBiophysics and Dialysis. Cardiopulmonary Perfusionand Advanced Surgical Techniques. THE CENTRALNERVOUS SYSTEM: Organization of the HumanCentral Nervous System. The Biophysics ofSensation—General. Vision. Audition and VestibularSense. Chemical Senses. SYSTEMS AND SIGNALS:Physiological Signal Processing. Bioelectrical Signals:The Electroencephalogram. Magnetic Stimulationand Biomagnetic Signals. Medical Imaging.Microscopy and Biophotonics. SYSTEMS INTEGRA-TION: Physiological Modeling. Biomechanics andBiomaterials. Biosensors and Emerging Technologies.Answers to Questions. Index.

Catalog no. C6513, February 2012, 782 pp.ISBN: 978-1-4200-6513-8, $99.95 / £49.99Also available as an eBook

A PracticalApproach toMedical ImageProcessingElizabeth Berry

Catalog no. C8245December 2007, 304 pp.ISBN: 978-1-58488-824-6$92.95 / £59.99

Fundamentalsof MRIAn InteractiveLearning ApproachElizabeth BerryElizabeth Berry Ltd, Leeds, UK

Andrew J. BulpittUniversity of Leeds, UK

“This interactive book with CD by Berry and Bulpittprovides an easy-to-follow, step-by-step process to effi-ciently assimilate and develop an understanding of thefundamentals of MRI. … The online teaching methodsand exercises are both intuitive and informative. Thiswill be an invaluable learning tool and resource forthose interested in grappling with the complexities ofMRI. I would highly recommend this interactive bookto those wanting an understanding of MRI.”

—Vincent Khoo, Royal Marsden Hospital, London

“The best text I have seen for students who are prepar-ing for an exam on MRI physics and for self-study.”

—Larry Zeng, University of Utah

Catalog no. C9012, December 2008, 320 pp.ISBN: 978-1-58488-901-4, $67.95 / £43.99

BiomolecularAction ofIonizingRadiationShirley LehnertMontreal GeneralHospital/McGill University,Quebec, Canada

Catalog no. IP164October 2007, 560 pp.Soft Cover, ISBN: 978-0-7503-0824-3$97.95 / £62.99Also available as an eBook






Imaging in Medical Diagnosis and Therapy Series

QuantitativeMRI in CancerEdited by

Thomas E. Yankeelov,David R. Pickens, andRonald R. PriceVanderbilt University, Nashville,Tennessee, USA

“… this book fills a void in the literature in this area.… The text is well written and, in particular, is wellorganized … The text has abundant mathematicderivations and numerous figures and diagrams(including many pulse sequence diagrams) … thetext fulfills the goal of providing a one-volumeoverview of quantitative oncologic MR imaging. It isideally suited to physician scientists and medicalphysicists working to advance research in the fieldand improve future clinical MR imaging applica-tions.”

—Michael Orsi, Radiology, July 2012

“… useful as an introductory text for imaging scien-tists and physicians who engage in quantitativecancer imaging methodologies with other modali-ties, such as nuclear medicine. … the greateststrengths of this book are its breadth of subject mat-ter, the uniformly large numbers of citations provid-ed by the chapter authors, and the detailed index.”

—Geoffrey Clarke, Medical Physics, March 2012

• Shows how MRI is used today for the diagnosisand therapy monitoring of cancer

• Discusses qualitative and quantitative aspects ofthe techniques

• Presents a detailed treatment of tissue character-ization using endogenous and exogenous con-trast agents

• Covers image processing in cancer

• Explores emerging trends in MR characteriza-tion, such as radiation therapy planning, molec-ular and cellular imaging, and hyperpolarizedMR

Selected Contents:

Physical Basis of Magnetic Resonance Imaging.Characterizing Tissue Properties with EndogenousContrast Mechanisms. Characterizing TissueProperties with Exogenous Contrast Agents. ImageProcessing in Cancer. Emerging Trends. Index.


New!

ComprehensiveBrachytherapyPhysical and ClinicalAspectsEdited by

Jack Venselaar, Ali S. Meigooni, Dimos Baltas, and Peter J. Hoskin

“This book … addresses the topic of brachytherapyfrom many vantage points (oncological, physical,and biological) and will satisfy readers from theentire radiotherapy community.”

—From the Foreword by Pierre Scalliet

Brachytherapy delivers a highly localized dose to a tar-get region using radionuclides implanted in or verynear to the tumor. This book provides a completeoverview of the field and covers related deliverymodalities, such as electronic brachytherapy. Alongwith exploring new clinical protocols, it discussesmajor advances under development, including imag-ing and robotics, strategies for improved dosimetry,Monte Carlo-based dose calculation, and optimiza-tion. The first part of the text offers a detailed under-standing of the underlying physics, design, and imple-mentation of the techniques. The second part pro-vides a hands-on guide for practitioners.

• Provides essential background information andpractical guidelines for quick reference

• Offers a balanced perspective from expertsacross the globe

• Includes recommendations from major profes-sional organizations

• Integrates the physics and clinical aspects of thepractice

• Presents a complete overview of the design, per-formance, and management of quality assuranceprograms

• Discusses research areas and future develop-ments

Selected Contents:

Introduction. Brachytherapy Dosimetry Methods.Brachytherapy Treatment Planning and Imaging.Uncertainties in Clinical Brachytherapy. ClinicalBrachytherapy. Developments in ClinicalBrachytherapy. Radiation Protection and QualityManagement in Brachytherapy.

Catalog no. K11997, November 2012, 535 pp.ISBN: 978-1-4398-4498-4, $199.95 / £127.00Also available as an eBook



11



Informatics in MedicalImagingEdited by

George C. KagadisUniversity of Patras, Rion, Greece

Steve G. LangerMayo Clinic, Rochester,Minnesota, USA

“… a helpful reference guide for medical physicists,radiologists, and administrative staff seeking addi-tional information on medical imaging informatics.… most chapters are well written and easy to readeven for readers without much prior knowledge inmedical imaging informatics. … well written byexperts in their respective fields and has good cover-age. Readers may also obtain a wealth of informa-tion in medical imaging informatics from referenceslisted at the end of each chapter … .”

—Yu Liu, Medical Physics, March 2012

This book reflects the considerable advances made inrecent years, most notably in radiology. It alsoaddresses other specialties, such as pathology, cardiol-ogy, dermatology, and surgery. The text discussesbasic imaging informatics protocols, PACS, and theelectronic medical record. It also details key instru-mentation and data mining technologies as well aspractical operational issues.

• Provides practical coverage of standards used tosupport the different aspects of information inthe health care enterprise

• Addresses issues concerning pathology, derma-tology, and radiation therapy informatics

• Discusses procurement, operations, teleradiolo-gy, and ethics in the radiology department

• Offers a detailed overview of key technologies,including operating systems, networks, and stor-age and image compression

Selected Contents:

Introduction to Informatics in Healthcare. StandardProtocols in Imaging Informatics. InformationSystems in Health Care Informatics. KeyTechnologies. Operational Issues. Medical Informaticsbeyond the Radiology Department.

Catalog no. K11526, October 2011, 367 pp.ISBN: 978-1-4398-3124-3, $157.95 / £101.00Also available as an eBook

Quality andSafety inRadiotherapyEdited by

Todd Pawlicki, Peter Dunscombe, Arno J. Mundt, andPierre Scalliet

“… it goes well beyond [QA tests] and tackles qual-ity at the highest levels of management and strate-gy. Virtually every aspect of quality and safety inradiotherapy is dissected … it serves as an excellentstarting point and contains many references for fur-ther reading. … an extremely useful first referencefor any manager wishing to review their currentquality management practices. …”

—Keri Owen, Scope, December 2011

“… well written and easy to read. Because of itscomprehensive nature, students as well as seasonedradiation therapy professionals will find this bookuseful. … No one book contains the range of topicscovered in this book. … the authors provide a briefreview of all these topics with enough detail to con-vey the salient points needed to understand the fun-damentals. Each chapter includes a wealth of refer-ences, which readers can use to supplement thematerial in this book. This is an important referenceon critically important topics.”

—Arthur Olch, Doody’s Review Service, June 2011

• Presents a global view of modern quality tech-niques that encourage improved patient careand safety

• Discusses both process- and people-specificapproaches to quality monitoring and improve-ment

• Includes examples that highlight the use ofmodem quality techniques from manufacturingand engineering

• Emphasizes real-world scenarios that offer guide-lines for setting up QA programs and perform-ing QA procedures

Selected Contents:

Introduction to Quality Assurance and QualityManagement. Medical Quality Assurance inRadiotherapy. Quality of Systems and Processes inRadiotherapy. Patient-Specific Quality Assurance inRadiotherapy.






AdaptiveMotionCompensationin RadiotherapyEdited by

Martin J. MurphyVirginia CommonwealthUniversity, Richmond, USA

This book provides a detailed treatment of onlineinterventional techniques for motion compensationradiotherapy. It explains how adaptive motion inter-vention is imaging-intensive and relies on near real-time image acquisition and processing. With a focuson the strategy of online motion compensation, thebook discusses necessary motion detection methodol-ogy, repositioning methodology, and how to interpretand respond to target movement data in real time. Itcovers methods of detection and correction and thenoffers examples. It also explores the distinct problemsin dose planning and delivery posed by each adapta-tion technology.

• Presents the full spectrum of image guidancetechniques for medical interventions in the con-text of critical issues of motion compensation

• Pays special attention to the interplay betweenbeam and target movement

• Explains problems with dose planning and deliv-ery of various methods

• Discusses fault detection and quality assurance

Selected Contents:

Introduction. Real-Time Tumor Localization.Theoretical Aspects of Target Detection and Tracking.Respiratory Gating. The CyberKnife® Image-GuidedFrameless Radiosurgery System. Fundamentals ofTracking with a LINAC MLC. Couch-Based TargetAlignment. Robotic LINAC Tracking Based onCorrelation and Prediction. Treatment Planning forMotion Adaptation in Radiation Therapy. TreatmentPlanning for Motion Management via DMLCTracking. Real-Time Motion Adaptation inTomotherapy® using a Binary MLC. Combination ofa LINAC with 1.5 T MRI for Real-Time Image-GuidedRadiotherapy. The ViewRayTM System. FaultDetection in Image-Based Tracking.


AdaptiveRadiationTherapyEdited by

X. Allen LiMedical College of Wisconsin,Milwaukee, USA

“The breadth of the book is impressive, and theauthors of each chapter provide a wealth of up-to-date references, making it easy for readers who areinterested in exploring certain ART techniques andtechnologies in more detail … The editor and theauthors are to be commended for producing a valu-able work on a very dynamic field that offers achance for meaningful clinical benefits to manypatients receiving radiation therapy for a variety ofcancer types and clinical indications.”

—Moyed Miften, Medical Physics

“The book contains a wealth of useful informationranging from practical workflow issues to directionsof future research. I recommend this book for med-ical physicists and radiation oncologists who areinterested in clinical practice and research utilizingadvanced imaging and radiation therapy technolo-gy.”

—James C.H. Chu, Rush University Medical Center

Selected Contents:

PART I TREATMENT PLANNING: Goals of RadiationTherapy. 3D and 4D Morphological Imaging forRadiation Treatment Planning. Biological Imaging forRadiation Treatment Planning. Biomarkers for EarlyRadiation Response. Inverse Treatment Planning.Biologically Based Models for Treatment Planning. …PART II TREATMENT DELIVERY: IMRT Delivery. CT-Based IGRT Technology. Non-CT-Based IGRT. OfflineCorrection Strategies for Interfraction Variations.Online Correction Strategies for InterfractionVariations. Intrafraction Variations and ManagementTechnologies. Stereotactic Radiation TherapyDelivery. Image-Guided Brachytherapy. QualityAssurance in Adaptive Radiation Therapy. PART IICLINICAL APPLICATIONS: Central Nervous System.Head and Neck. Breast. Lung. Liver. Prostate.Sarcoma.

Catalog no. K10840, January 2011, 427 pp.ISBN: 978-1-4398-1634-9, $157.95 / £101.00Also available as an eBook



13



New!

Proton andCarbon IonTherapyEdited by

C.-M. Charlie MaFox Chase Cancer Center,Philadelphia, Pennsylvania, USA

Tony LomaxPaul Scherrer Institute, VilligenPSI, Switzerland

An up-to-date guide to using proton and carbon iontherapy in modern cancer treatment, this book offersa balanced and critical assessment of state-of-the-arttechnologies, major challenges, and the future out-look of the field. It covers the physics and radiobiolo-gy basics of proton and ion beams, dosimetry meth-ods and radiation measurements, and treatmentdelivery systems. The book also gives practical guid-ance on patient setup, target localization, and treat-ment planning for clinical proton and carbon ion ther-apy, offering detailed reports on the treatment of var-ious cancers.

• Discusses advances in the radiobiology of pro-tons and heavy ions

• Describes the latest particle accelerators and par-ticle therapy delivery techniques

• Covers modern dosimetry, image guidance, andtreatment planning methods for particle therapy

• Presents recent treatment techniques and out-comes of proton and carbon ion therapy

Selected Contents:

Introduction to Proton and Carbon Ion Therapy.Accelerators for Proton and Ion Therapy. BeamDelivery Systems for Particle Therapy. Requirementsfor Particle Therapy Facilities. Radiobiology of Protonand Carbon Ion Therapy. Dosimetry for Proton andCarbon Ion Therapy. Image-Guided Proton andCarbon Ion Therapy. Treatment Planning forScanned Particle Beams. Conformal Proton Therapy.Clinical Experience with Particle Radiotherapy. FutureProspects for Particle Therapy. Index.

Catalog no. K10826, October 2012, 250 pp.ISBN: 978-1-4398-1607-3, $129.95 / £82.00Also available as an eBook

Image-GuidedRadiationTherapyEdited by

J. Daniel BourlandWake Forest School of Medicine,Winston-Salem, North Carolina,USA

“Image-Guided Radiation Therapy contains valu-able information on the history of image-guidedradiation treatment (IGRT), imaging systems, andsecondary technologies. It is extensive in the expla-nation of how such systems are used clinically, andit covers most of the devices offered by manufactur-ers today. It is truly a remarkable compilation offocused and detailed chapters that span the art ofimage-guided radiation therapy.”

—Michael S. Gossman, Medical Physics, June 2012

• Explains the clinical uses and impact of IGRTtechnologies on radiation treatment

• Offers the research and clinical expertise of theinventors of IGRT technologies and early users ofimaging technologies

• Describes conventional gantry, ring gantry, androbotic linac systems as well as imaging tech-nologies that use ultrasound, fan-beam CT,cone-beam CT, x-ray, and PET/CT

• Surveys the technology behind real-time moni-toring/tracking

• Presents clinical applications of head–neck,prostate, lung, brain, and breast cancer treat-ments

• Discusses future R&D

Selected Contents:

Optical and Remote Monitoring IGRT. Ultrasound-Guided Radiation Therapy. In-Room CT System forIGRT. Megavoltage Fan-Beam CT IGRT. KilovoltageCone-Beam CT Guidance of Radiation Therapy.Megavoltage Cone-Beam IGRT. Kilovoltage X-RayIMRT and IGRT. Kilovoltage Radiography for RoboticLinac IGRT. Respiratory-Correlated CT. 4D PET/CT inRadiotherapy. On-Board Digital Tomosynthesis: AnEmerging New Technology for IGRT. ImageRegistration and Segmentation in Radiation Therapy.

Catalog no. K10143, February 2012, 256 pp.ISBN: 978-1-4398-0273-1, $129.95 / £82.00Also available as an eBook





New!

Physics ofThermalTherapyFundamentals andClinical ApplicationsEdited by

Eduardo MorosMoffitt Cancer Center, Tampa,Florida, USA

This book covers the basic principles, practicalaspects, and clinical applications of thermal therapy. Itshows how the use of controlled heat in medicine andbiology involves electromagnetics, acoustics, thermo-dynamics, heat transfer, and imaging sciences. Thebook discusses challenges in the use of thermal ener-gy on living tissues and explores genetic, cellular, andphysiological responses that will help in combatingcancer. It also highlights recent advances, includingthe treatment of solid tumors using image-guidedthermal therapy, microbubbles, nanoparticles, andother cutting-edge techniques.

Selected Contents:

Foundations of Thermal Therapy Physics:Fundamentals of Bioheat Transfer. Thermal DoseModels: Irreversible Alterations in Tissues. PracticalClinical Thermometry. Physics of ElectromagneticEnergy Sources. The Physics of Ultrasound EnergySources. Numerical Modeling for Simulation andTreatment Planning of Thermal Therapy: Ultrasound.Numerical Modeling for Simulation and TreatmentPlanning of Thermal Therapy. Clinical ThermalTherapy Systems: External ElectromagneticMethods and Devices. Interstitial ElectromagneticDevices for Thermal Ablation. Clinical ExternalUltrasonic Treatment Devices. Endocavity andCatheter-Based Ultrasound Devices. Physical Aspectsof Emerging Technology for Thermal Therapy:Evolving Tools for Navigated Image-Guided ThermalCancer Therapy. Temperature Imaging UsingUltrasound. Focused Ultrasound Applications forBrain Cancer. Extracorporeal Ultrasound-GuidedHigh-Intensity Focused Ultrasound Ablation forCancer Patients. Using Hyperthermia to AugmentDrug Delivery. Magnetic Nanoparticles for CancerTherapy. Application of Gold Nanoparticles in LaserThermal Therapy. Thermochemical Ablation.


New!

Physics ofMammographicImagingEdited by

Mia K. MarkeyThe University of Texas at Austin,USA

Covering the fundamentals of image formation, inter-pretation, analysis, and modeling, this volume pres-ents a detailed, state-of-the-art overview of the tech-nical aspects of mammographic imaging and its clini-cal context. It covers the use of mammographic imag-ing in the detection, diagnosis, treatment planning,and monitoring of breast cancer. Expert authors givea balanced summary of core topics such as digitalmammography, contrast-enhanced mammography,stereomammography, breast tomosynthesis, andbreast CT. The book highlights the use of mammo-graphic imaging with complementary breast imagingmodalities, such as ultrasound, MRI, and nuclear med-icine techniques. It also discusses critical issues thatinclude computer-aided diagnosis, perception, andquality assurance.

Selected Contents:

Image Formation: Fundamentals of DigitalMammography. Contrast-Enhanced DigitalMammography. Stereo Mammography. BreastTomosynthesis. Breast CT. Comparison of AdvancedX-Ray Modalities. Image Interpretation: BreastCancer Detection and Diagnosis. Image-GuidedProcedures and Surgical Planning. Displays for BreastImaging. Perception of Mammographic Images.Image Analysis and Modeling: Physical BreastPhantoms. Digital Phantoms for Breast Imaging.Observer Models for Breast Imaging. Current Statusof Computer-Aided Detection of Breast Cancer.Complementary Approaches: Breast Ultrasound.Breast MRI. Nuclear Medicine Imaging of the Breast:History, Clinical Application and Integration, andFuture. Future Directions: Breast Elasticity Imaging.Electrical Impedance Imaging and Spectroscopy ofthe Breast. Optical Imaging of the Breast. Outlookfor Computer-Based Decision Support in BreastCancer Care.




15



New!

CancerNanotechnologyPrinciples andApplications inRadiation OncologyEdited by

Sang Hyun ChoGeorgia Institute of Technology,Atlanta, USA

Sunil KrishnanUniversity of Texas MD Anderson Cancer Center, Houston,USA

Reflecting profound advances in the application ofnanotechnology to radiation oncology, this workdemonstrates how the unique physicochemical prop-erties of nanoparticles lead to novel strategies for can-cer treatment and detection. After an introduction tothe first principles of radiation physics and radiationbiology, the book discusses the fabrication ofnanoparticles, the safety of nanoparticles, and thequantification of nanoparticle accumulation within tis-sues. It then highlights the computational and exper-imental techniques that underlie the use of nanopar-ticles for imaging and treating tumors. The book con-cludes with discussions on regulatory issues related tohuman use and a summary of envisioned clinicaltranslation.

• Offers a complete overview of the intersection ofnanotechnology and radiation oncology

• Presents the full spectrum of developments inexperimental research, preclinical testing, andpotential clinical uses of nanomaterials asenhancers of radiation therapy efficacy

• Describes the basic principles of cancer targetingby nanomaterials

• Covers safety and regulatory issues

• Explores the most promising approaches, includ-ing the use of nanoparticles for radiationresponse modulation and thermal ablation treat-ment of tumors

Selected Contents:

Basic Principles of Radiation Oncology andRadiosensitization. Synthesis, Safety, and Imaging ofNanomaterials for Cancer Applications.Nanomaterials for Radiation Therapy. Nanomaterialsfor Hyperthermia and Thermal Therapy. FutureOutlook.


TargetedMolecularImagingEdited by

Michael J. WelchWashington University, St. Louis,Missouri, USA

William C. EckelmanUniversity of California–SanDiego, La Jolla, USA

“This text successfully fulfills its goal by introducingthe concepts of molecular imaging agent develop-ment and then providing a diverse set of examples oftargeted agents. … The strength of this book is itsemphasis of case studies that are representative ofthe various types of translational studies that can beperformed using molecular imaging.”

—Michael T. Munley, Medical Physics, August 2012

Covering the fundamental concepts of molecularimaging, this book presents state-of-the-art diseasemodels, imaging studies in animals, imaging in initialhuman studies, and the application of molecularimaging in pharmacy and drug discovery. It includesexamples from human studies with imaging of breastcancer, cardiovascular disease, and neurodegenera-tive diseases. The book is a valuable tool for readersinvolved with targeted molecular imaging, medicinalchemistry, pharmacology, radiology, and medicalphysics.

• Discusses various methods of validating a newtargeted probe through

• Includes imaging examples of breast cancer, car-diovascular disease, and neurodegenerative dis-eases

• Describes basic principles, disease models, andapplications in pharmacology and pharmacy

• Presents in vitro studies, small animal studies,and targeted radiopharmaceuticals

Selected Contents:

In Vitro Studies. Small Animal Studies.Radiopharmacology and Radiopharmacy. CaseStudies on Developing Target Nonnuclear Probes.Case Studies on Developing Targeted Radiotracers.

Catalog no. K11953, February 2012, 388 pp.ISBN: 978-1-4398-4195-2, $169.95 / £108.00Also available as an eBook




New and Bestselling References

Proton Therapy PhysicsEdited by

Harald PaganettiMassachusetts General Hospitaland Harvard Medical School,Boston, USA

This practical guide goes beyond current books onproton therapy to provide an in-depth overview of thephysics aspects of this radiation therapy modality,eliminating the need to dig through information scat-tered in the medical physics literature. Along withexploring QA issues and biological considerations, itcollects the latest clinical studies on the use of protonsin treatment planning and radiation monitoring.

• Covers all delivery methods of proton therapy,including beam scanning and passive scattering

• Discusses clinical aspects, such as treatmentplanning and QA

• Explores such research topics as biological treat-ment planning

• Offers insight on the past, present, and future ofproton therapy from a physics perspective

• Includes references for further reading

Selected Contents:

Proton Therapy: History and Rationale. Physics ofProtons Stopping in Matter. Proton Accelerators.Characteristics of Clinical Proton Beams. BeamDelivery Using Passive Scattering. Particle BeamScanning. Dosimetry. Quality Assurance andCommissioning. Monte Carlo Simulations. Physics ofTreatment Planning for Single-Field Uniform Dose.Physics of Treatment Planning Using Scanned Beams.Dose Calculation Algorithms. Precision andUncertainties in Proton Therapy for NonmovingTargets. Precision and Uncertainties in ProtonTherapy for Moving Targets. Treatment-PlanningOptimization. In Vivo Dose Verification. Basic Aspectsof Shielding. Late Effects from Scattered andSecondary Radiation. The Physics of Proton Biology.Fully Exploiting the Benefits of Protons: Using RiskModels for Normal Tissue Complications inTreatment Optimization. Index.


New!

Monte CarloCalculations inNuclearMedicineSecond EditionApplications inDiagnostic ImagingEdited by

Michael Ljungberg, Sven-Erik Strand, andMichael A. KingThis book covers the applications of Monte Carlo cal-culations in nuclear medicine and critically reviewsthem from a diagnostic perspective. New chapters inthis edition cover codes and applications in pre-clini-cal PET and SPECT. The book explains how MonteCarlo methods and software packages can be appliedto evaluate scatter in SPECT and PET imaging, colli-mation, and image deterioration.

• Provides a guide for researchers developingmethods to improve image resolution

• Describes various computer programs and criti-cally reviews their areas of application

• Demonstrates how Monte Carlo techniques canbe used to simulate complex imaging systems

• Includes five new chapters that cover new codesand applications in areas such as pre-clinical PETand SPECT systems

Selected Contents:

Introduction to the Monte Carlo Method. VarianceReduction Techniques. Anthropomorphic Phantoms:Early Developments and Current Advances. TheGamma Camera: Basic Principles. Positron EmissionTomography. The SimSET Program. The SIMINDMonte Carlo Program. GATE: A Toolkit for MonteCarlo Simulations in Tomography and RadiationTherapy. The MCNP Monte Carlo Program. The EGSFamily of Code Systems. ASIM: An Analytic PETSimulator. Monte Carlo in SPECT Scatter Correction.Monte Carlo in Quantitative 3D PET: Scatter. Designof Molecular Imaging Systems Assisted by the MonteCarlo Methods. Introduction to Task-BasedAssessment of Image Quality for InvestigatorsEmploying Monte Carlo Simulation of ImagingSystems. Monte Carlo Method Applied in NuclearMedicine Dosimetry.




17



Essentials ofForensicImagingA Text-AtlasAngela D. LevyGeorgetown University Hospital,Washington, D.C., andUniformed Services University ofthe Health Sciences, Bethesda,Maryland, USA

H. Theodore Harcke, Jr.Armed Forces Institute of Pathology, Washington, D.C.,and Uniformed Services University of the Health Sciences,Bethesda, Maryland, USA

“The work is very well done and makes a significantcontribution to the literature on the topic … . [It]addresses, and is applicable to, the whole range offorensic autopsies. The printing/illustration qualityis outstanding.”

—Joel Lichtenstein, University of Washington

“The book is unusually well illustrated through cor-relation of photographs and radiological images ofthe highest quality. … The book is certain to findextended use in training programs and daily deathinvestigation and documentation.”—William A. Murphy, Jr., University of Texas MD Anderson

Cancer Center

“I believe that the book will be useful for practicingforensic pathologists. The numerous examples cover-ing a wide variety of forensic cases … illustrate thevalue of imaging techniques in medicolegal deathinvestigation.”

—John Butts, University of North Carolina at Chapel Hill

This text-atlas provides readers with a foundation forapplying modern cross-sectional imaging to forensicautopsy. The book integrates more than 300 colorimages with basic forensic pathology in a topical for-mat. Following an introduction to basic concepts andimaging techniques, subsequent chapters are organ-ized by cause of death. The presentation is supportedby full text explanations that review relevant forensicand radiologic principles.

Selected Contents:

Introduction to Forensic Imaging. IntegratingImaging and Autopsy. Postmortem Change andDecomposition. Gunshot Wounds. Blunt Force Injury.Death from Fire and Burns. Blast Injury. Sharp ForceInjury. Death by Drowning and Bodies Found inWater. Suicide. Natural Death. Other Causes ofDeath. Beyond Standard Autopsy.


PracticalRadiologicalAnatomySarah McWilliamsSt Thomas’ Hospital, London, UK

Practical Radiological Anatomy is an illustrated andconcise revision book for radiology trainees who arelearning to interpret all modes of imaging. The essen-tial revision book for doctors training in radiology andpreparing for the first FRCR exam, PracticalRadiological Anatomy is also of great value toadvanced radiology practitioners, nurse practitioners,emergency medicine doctors, and radiographers.

• Organizes each chapter by body system, withcase studies to illustrate the application of anatomy

• Provides indispensable guidelines on how tointerpret images

• Demonstrates the key features of basic anatomywith many clear images and examples of commonly encountered pitfalls

• Matches the current curriculum of the FRCR Part 1 and Part 2A exams

• Includes both conventional imaging and cross-sectional CT and MRI anatomy to aid inthe preparation for the FRCR 2A modules

Selected Contents:

Neuroimaging. Imaging of the Nasopharynx, Face,and Neck. Chest Imaging. Gastrointestinal Imaging I:Oesophagus, Stomach, and Bowel. GastrointestinalImaging II: Liver, Spleen, Pancreas, Adrenals, BiliaryTract, and Aorta. Imaging of the GenitourinarytTract. Imaging of the Spine. Imaging of the UpperLimb. Imaging of the Lower Limb. On-Call Top Tips.

Catalog no. K17220, January 2011, 416 pp.Soft Cover, ISBN: 978-1-85315-800-1$63.95 / £39.99





Biosensors andMolecularTechnologiesfor CancerDiagnosticsEdited by

Keith E. HeroldUniversity of Maryland, CollegePark, USA

Avraham RasoolyNational Cancer Institute, Rockville, and the FDA Centerfor Devices and Radiological Health, Silver Spring,Maryland, USA

Bridging the gap between research and clinical appli-cation, this volume explores the use of biosensors aseffective alternatives to the current standard methodsin cancer diagnosis and detection. It describes themajor aspects involved in detecting and diagnosingcancer as well as the basic elements of biosensors andtheir applications in detection and diagnostics.• Covers many optical-based biosensors, including

surface plasmon resonance, evanescent waveand waveguides, optical imaging, luminescence,and photoacoustic analysis

• Discusses several modes of electrochemicalbiosensors, such as potentiometric and ampero-metric biosensors

• Examines electronic and magnetic technologiesfor cancer analysis, covering field effect transis-tors, magnetic resonance, and electric field-based biosensors

• Explores such novel developments as thermo-metric sensing and optomechanical cantilever-based technologies

• Presents the technology and schematics of thedevices, helping nonengineers understand thebackground of biosensors

Selected Contents:

Optical Technologies for Cancer Detection andDiagnostics: Surface Plasmon Resonance. OpticalTechnologies for Cancer Detection and Diagnostics:Evanescent Wave and Waveguide Biosensors. OpticalTechnologies for Cancer Detection and Diagnostics:Spectrometry for Cancer Analysis. OpticalTechnologies for Cancer Detection and Diagnostics:Optical Imaging for Cancer Analysis. OpticalTechnologies for Cancer Detection and Diagnostics:Fluorescence, Luminescence, Refractive IndexDetection Technologies. Optical Technologies forCancer Detection and Diagnostics: Photoacoustic forCancer Analysis. Electrochemical Biosensors.Electronic and Magnetic Technologies for CancerAnalysis. Thermometric Sensing. Cantilever-BasedTechnology. Index.

Catalog no. K11937, May 2012, 844 pp.ISBN: 978-1-4398-4165-5, $169.95 / £108.00Also available as an eBook

Radio-pharmaceuticalsIntroduction to DrugEvaluation and DoseEstimationLawerence E. WilliamsCity of Hope National MedicalCenter, Duarte, California, USA

“This high-quality hardcover volume is a textbookproviding an exposition … on the development andevaluation of antibody-based and other targetedradionuclide therapies … unique in the targetedradionuclide therapy literature.”

—Medical Physics, May 2012

“The book covers a very important topic and fills agap not covered by others. I believe that it will be avery valuable in our education of Ph.D. students andalso very valuable for researchers in this area. I willrecommend the book to my colleagues.”

—Sven-Erik Strand, University of Lund

“The book is written in a very clear style, and isaccessible not only to physicists, but to any profes-sional involved in radiopharmaceutical developmentand clinical or preclinical experiments. … Through30 years of experience, Prof. Williams shares with usideas, caveats, and hints applicable to the domain.In the acknowledgements, he indicates his will to‘put some chips back in the pot.’ This is exactly howI receive this book: a senior scientist in our field issharing his experience—and I dare say his wisdom—with us. This atypical book is going to be an essen-tial part of my library.”

—Manuel Bardies, INSERM

Selected Contents:

Tumor Targeting and a Problem of Plenty. PreclinicalDevelopment of Radiopharmaceuticals and Planningof Clinical Trials. Selection of Radiopharmaceuticalsfor Clinical Trials. Absorbed Dose Estimation andMeasurement. Determination of Activity In Vivo.Modeling and Temporal Integration. Functions Usedto Determine Absorbed Dose Given ActivityIntegrals. Absorbed Dose Estimates without ClinicalCorrelations. Dose Estimates and Correlations withLaboratory and Clinical Results. Multiple-ModalityTherapy of Tumors. Allometry (Of Mice and Men).Summary of Radiopharmaceuticals and DoseEstimation. Index.




19



Husband &Reznek’sImaging inOncology3rd EditionEdited by

Janet HusbandRoyal Marsden Hospital,Sutton, UK

Rodney H. ReznekSt Bartholomew'sHospital, London, UK

The third edition of this comprehensive, award-win-ning book addresses all aspects of cancer imaging,from diagnosis to long-term follow up. It is organizedinto nine clearly defined sections, with the core of thetext focusing on the application of imaging in alltumors. The book gives an extensively referenced, evi-dence-based analysis of the role of imaging in plan-ning treatment. It covers the imaging of metastaticdiseases as well as cancer imaging.

Experienced professionals also examine the advan-tages and limitations of all relevant imaging modali-ties, including ultrasound, CT, MRI, PET/CT, and othernuclear medicine techniques. The book’s color dia-grams of the staging systems enable readers to easilyunderstand and memorize these often complex sys-tems. In addition, key points and summaries are pro-vided throughout for quick revision.

• Includes a new section on functional imaging

• Contains extensive references and over 2,500images

• Presents material from pioneering clinicalresearchers of CT and MRI in cancer care

Selected Contents:

General Principles. Primary Tumor Evaluation andStaging. Hematology Malignancy. Pediatrics.Metastases. Imaging and Treatment. Effects ofTreatment on Normal Tissue, TheImmunocompromised Host. Functional Imaging.

Catalog no. DU5516, December 2009, 1520 pp.ISBN: 978-0-415-45167-3, $785.00 / £500.00Also available as an eBook

Handbook ofPhysics inMedicine andBiologyEdited by

Robert SplinterUniversity of North Carolina atCharlotte, USA

“The handbook includes hundreds of diagrams,images, and tables, making it a useful tool for bothmedical physicists/engineers and other medical/biol-ogy specialists … includes materials that are rarelycombined together, which strengthens its interdisci-plinary approach.”

—Physics in Medicine and Biology, 55 (2010)

“… an excellent work by a highly competent team.The book chapters follow logically from the proper-ties of the cell membrane through sensors and elec-troreception, biomechanics, and fluid dynamics tothe recording of bioelectrical signals, bioelectricimpedence analysis, x-ray and computed tomogra-phy, magnetic resonance imaging, nuclear medicine,and ultrasonic and thermographic imaging … keepthis book close at hand and do not hesitate to use itfrequently.”

—BioMedical Engineering OnLine, 2010

This handbook presents a quantitative physicaldescription of all aspects of cellular and organ per-formance along with the methods used to measurethese functions. Moreover, it covers the physics nec-essary to understand the theoretical and practicalbasis for the development of diagnostic and thera-peutic tools. It offers readers a foundation in relevantphysical principles and technology critical to under-standing biological functioning for application to bio-medical research and healthcare.

Selected Contents:

Anatomical Physics. Physics of Perception.Biomechanics. Electrical Physics. Diagnostic Physics.Physics of Accessory Medicine. Physics ofBioengineering.

Catalog no. 75241, April 2010, 548 pp.ISBN: 978-1-4200-7524-3, $167.95 / £107.00Also available as an eBook




Biomedical Optics

New!

CoherentRamanScatteringMicroscopyEdited by

Ji-Xin ChengPurdue University, WestLafayette, Indiana, USA

Xiaoliang Sunney XieHarvard University, Cambridge, Massachusetts, USA

Edited by pioneers in the field and with contributionsfrom a distinguished team of experts, this color bookexplains how CRS can be used to obtain a point-by-point chemical map of live cells and tissues. It discuss-es the principles of nonlinear optical spectroscopy andpresents the theories of contrast mechanisms perti-nent to CRS microscopy. The text then providesimportant technical aspects of CRS microscopy,including microscope construction, detectionschemes, and data analyses. It also covers applicationsthat demonstrate how CRS microscopy has become avaluable tool in biomedicine.

Selected Contents:

Theory: Theory of Coherent Raman Scattering.Coherent Raman Scattering under Tightly FocusedConditions. Platforms: Construction of a CoherentRaman Microscope. Stimulated Raman ScatteringMicroscopy. Femtosecond versus Picosecond Pulsesfor Coherent Raman Microscopy. Wide-Field CARSMicroscopy. Vibrational Spectromicroscopy byCoupling Coherent Raman Imaging withSpontaneous Raman Spectral Analysis. CoherentControl in CARS. Fourier Transform CARSMicroscopy. CRS with Alternative Beam Profiles.Vibrational Phase Microscopy. Multiplex CARSMicroscopy. Interferometric Multiplex CARS.Photonic Crystal Fiber-Based Broadband CARSMicroscopy. Multiplex Stimulated Raman ScatteringMicroscopy. Applications: Imaging Myelin Sheath ExVivo and In Vivo by CARS Microscopy. Imaging LipidMetabolism in Caenorhabditis elegans and OtherModel Organisms. Lipid-Droplet Biology andObesity-Related Health Risks. White Matter Injury:Cellular-Level Myelin Damage Quantification in LiveAnimals. CARS Microscopy Study of Liquid Crystals.Live Cell Imaging by Multiplex CARSMicrospectroscopy. Coherent Raman ScatteringImaging of Drug Delivery Systems. …

Catalog no. K13060, October 2012, 610 pp.ISBN: 978-1-4398-6765-5, $149.95 / £95.00

Handbook ofBiomedicalOpticsEdited by

David A. Boas,Constantinos Pitris, andNimmi Ramanujam

“This handbook is a successful attempt to provide asmuch as possible information to a number of physi-cists, R&D engineers, clinicians, and scientists whowould like to apply contemporary concepts andtechniques to solving biomedical diagnostic andtherapeutic challenges. It often covers areas that arenot conventionally addressed, and is generallythought-provoking and brain-stimulating … anexcellent tutorial for students and young investiga-tors … a relevant reference for scientists and also agood teaching tool. … a good balance betweenintroductory knowledge and high-level expertise,without burdening the reader with excessive data.What makes it really unique is its scope. … An addi-tional value is that the book is truly state of the art.”

—Boris Gramatikov, BioMedical Engineering OnLine,February 2012

“… highly recommend it. It provides an in-depthreview and overall treatment covering most areas ofbiomedicine from the ground-level foundations ofoptics to background on photon transport in tissues,theory, and experiments. … a major contribution tothe biomedical optics field and will serve as a greatresource.”

—Journal of Biomedical Optics, December 2011

Taking a broad yet detailed approach, this handbookcovers light-based diagnostic methodologies andlight-mediated therapeutics as well as concepts andcutting-edge optical methods used in research andpractice. Extensively illustrated, the book also discuss-es the advantages and disadvantages of various tech-niques.

Selected Contents:

Background. Spectroscopy and Spectral Imaging.Tomographic Imaging. Microscopic Imaging.Molecular Probe Development. Phototherapy.

Catalog no. 90364, June 2011, 831 pp.ISBN: 978-1-4200-9036-9, $157.95 / £101.00Also available as an eBook



21

Biomedical Optics


Handbook ofPhotonics forBiomedicalScienceEdited by

Valery V. TuchinSaratov State University, Russia

“Many of the chapters are written by leaders in theirfield and thus provide both good foundationaldescriptions as well as up-to-date accounts of thestate of the field. … the book does well throughout:providing a better than skin-deep introduction to asubject, focusing on the core issues within a field andproviding references to enable more detailed investi-gation. … It brings together much of the mostimportant literature into an easily accessible form.… a valuable addition to the collection ofresearchers, engineers and clinicians alike.”

—Peter R.T. Munro, Contemporary Physics, 2011

This handbook analyzes achievements, trends, andperspectives of photonics in its application to bio-medicine. World-renowned experts describeadvanced biophotonics methods and techniquesintensively developed in recent years, enabling read-ers to become familiar with major, state-of-the-artresults in biophotonics science and technology. Thetext covers finite-difference time-domain simulation,photothermal therapy, nanoparticle photonic tech-nologies, and much more.

Selected Contents:

FDTD Simulation of Light Interaction with Cells forDiagnostics and Imaging in Nanobiophotonics.Plasmonic Nanoparticles: Fabrication, OpticalProperties, and Biomedical Applications. Transfectionby Optical Injection. Advances in FluorescenceSpectroscopy and Imaging. Applications of OpticalTomography in Biomedical Research. FluorescenceLifetime Imaging and Metrology for Biomedicine.Raman and CARS Microscopy of Cells and Tissues.Resonance Raman Spectroscopy of Human Skin forthe In Vivo Detection of Carotenoid AntioxidantSubstances. Polarized Light Assessment of ComplexTurbid Media Such as Biological Tissues UsingMueller Matrix Decomposition. …

Catalog no. K10313, May 2010, 868 pp.ISBN: 978-1-4398-0628-9, $167.95 / £107.00Also available as an eBook

Coming soon!

AdvancedBiophotonicsTissue OpticalSectioningEdited by

Ruikang K. WangUniversity of Washington,Seattle, USA

Valery V. TuchinSaratov State University, Russia

This reference provides an overview of optical imag-ing and manipulation technologies in biophotonics,covering both basic and advanced optical imagingtechniques. It reviews the principles and fundamentalsof bioimaging and molecular imaging/manipulationtechniques. It also covers instrumentation, basic algo-rithms, and data processing methods and exploresapplications in biotechnology, biomedical engineer-ing, biophysics, medicine, and pharmacology.

• Presents a range of imaging and manipulationtechniques

• Covers new and emerging techniques as well asestablished technologies

• Discusses data processing and instrumentation

• Describes advanced imaging technologies basedon different approaches for the selection ofimage-carrying photons and optical tissue sec-tioning

Selected Contents:

Spatial and Temporal Frequency Domain Imaging.Polarization Imaging. Unified Monte Carlo Modeling.Confocal Microscopy. Multiphoton Microscopy andSHG. Optical Coherence Tomography: Theory andTechnology Developments. Standards andTraceability for Optical Coherence Tomography.Advances in Doppler OCT. OpticalMicroangiography. Advances in Blood Flow Imaging.Phase-Sensitive Optical Coherence Tomography forNanotechnology. Optical Coherence Tomographyand Fluorescence Spectroscopy: Optical Slicing PlusBiochemical Probing. Multimodal TomographyCombining Optical Coherence Tomography (OCT)with Fluorescence Laminar Optical Tomography(FLOT). Multiscale Multimodal Imaging of Structureand Function. Quantitative Assessment of ClinicalOptical Coherence Tomography Data. PhotoacousticImaging. Array-Based Photoacoustic Microscopy.Optoacoustic Molecular Imaging: Methods andApplications. …

Catalog no. K14253, June 2013, c. 576 pp.ISBN: 978-1-4398-9581-8, $199.95 / £127.00Also available as an eBook




Image Processing and Informatics

PracticalBiomedicalSignal AnalysisUsing MATLAB®

K.J. Blinowska and J. ZygierewiczUniversity of Warsaw, Poland

This book not only covers the current techniques ofbiomedical signal processing, but it also offers hands-on guidance on which methods are appropriate for agiven task and different types of data. The first sever-al chapters of the text describe signal analysis tech-niques—including new and advanced methods—inan easy and accessible way. MATLAB® routines are list-ed when available and freely available software is dis-cussed where appropriate. The final chapter exploresthe application of the methods to a broad range ofbiomedical signals, highlighting problems encoun-tered in practice.

A unified overview of the field, this book explains howto properly use signal processing techniques for bio-medical applications and avoid misinterpretations andpitfalls. It helps readers choose the appropriatemethod as well as design their own methods.

• Provides hands-on guidance for those working in the area of biomedical signal analysis

• Covers tools for stationary and nonstationarysignals, nonlinear methods of signal analysis,and models and measures for multivariate signals

• Compares the advantages and disadvantages ofdifferent methods in the context of applications

• Refers to MATLAB routines and freely availablesoftware found on the Internet

• Applies the methods to a variety of electric,magnetic, and acoustic signals

Selected Contents:

Introductory Concepts. Single Channel (Univariate)Signal. Multiple Channels (Multivariate) Signals.Application to Biomedical Signals. References. Index.


SignalProcessing inMagneticResonanceSpectroscopywith BiomedicalApplicationsDzevad Belkic andKaren BelkicKarolinska Institute, Stockholm, Sweden

“… immensely useful as a practical resource hand-book to dip into from time to time and to find spe-cific advice on issues faced during the course of workin MR techniques for cancer research. … the bestfeature of this book is how it positions the very prac-tical area of digital signal processing in the contex-tual framework of a much more esoteric and funda-mental field—that of quantum mechanics. Thedirect link between quantum-mechanical spectralanalysis and rational response functions and thegeneral role of quantum mechanics in signal pro-cessing is beautifully brought out in Chapter 2. Thischapter alone is worth the price of the book and willespecially appeal to a multi-disciplinary audiencecomprising NMR spectroscopists, atomic and molec-ular physicists, and physicists who work in the foun-dations of quantum mechanics.”

—Kavita Dorai, Contemporary Physics, January 2013

Selected Contents:

Basic Tasks of Signal Processing in Spectroscopy. TheRole of Quantum Mechanics in Signal Processing.Harmonic Transients in Time Signals. Signal-NoiseSeparation via Froissart Doublets. Padé Processing forMagnetic Resonance (MR) Total Shape Spectra fromin vivo Free Induction Decays (FIDs). ExactReconstructions of Spectral Parameters by FPT.Machine Accurate Padé Quantification and ExactSignal-Noise Separation. Magnetic ResonanceSpectroscopy (MRS) and Magnetic ResonanceSpectroscopic Imaging (MRSI) in Neuro-Oncology:Achievements and Challenges. Padé Quantificationof Malignant and Benign Ovarian MRS Data. BreastCancer and Non-Malignant Breast Data:Quantification by FPT. Multiplet Resonances in MRSData from Normal and Cancerous Prostate. GeneralDiscussion. Conclusions and Outlooks.




23



ImageProcessing with MATLAB®

Applications inMedicine and BiologyOmer Demirkaya, Musa Hakan Asyali, and Prasanna K. SahooThis text explains complex, theory-laden topics inimage processing through real-world examples andMATLAB® algorithms. The authors emphasize three-dimensional processing and analysis as well as statisti-cal and stochastic modeling. They cover the areas ofnonlinear diffusion filtering and PDE-based image fil-tering and highlight applications with images frommedicine and biology.

• Provides MATLAB algorithms to help scientistsand researchers quickly identify the most effec-tive solution method for a particular problem athand

• Enables a diverse set of readers to comprehendthe material by striking the right balancebetween theory and practice

• Covers three-dimensional processing and analy-sis along with statistical and stochastic modeling

• Explores nonlinear diffusion filtering and PDE-based image filtering

• Addresses relatively advanced topics, includingMarkov random field-based image segmentation

• Includes images from medicine and biology

• Contains real-world examples and exercises inevery chapter

Selected Contents:

Medical Imaging Systems. Fundamental Tools forImage Processing and Analysis. Probability Theory forStochastic Modeling of Images. Two-DimensionalFourier Transform. Nonlinear Diffusion Filtering.Intensity-Based Image Segmentation. ImageSegmentation by Markov Random Field Modeling.Deformable Models. Image Analysis. Applications.Appendices.


PACS andDigital MedicineEssential Principlesand Modern PracticeYu LiuSt. Luke’s Medical Center,Milwaukee, Wisconsin, USA

Jihong WangUniversity of Texas MD AndersonCancer Center, Houston, USA

“For someone … looking for a concise summary ofPACS, its environs (both departmental and enter-prise), components, and support issues—this bookwould be an excellent choice.”

—Steve G. Langer, Medical Physics, October 2012

“… a thorough and practical reference for radiolo-gists, administrators, engineers, and others whomight create, manage, or use such a system. …”

—SciTech Book News, February 2011

This book presents key principles and practical stepsfor PACS and EHR implementations and maintenance.It shows how PACS are used in radiology, teleradiolo-gy, cardiology, pathology, and radiation oncology.The authors specifically cover PACS system compo-nents, quality control, IT infrastructures, networks,and data storage technologies.

• Explains how PACS are used in radiology, telera-diology, cardiology, pathology, and radiationoncology

• Describes industry standards, such as DICOM,HL7, and IHE, as well as security, privacy, andsafety regulations, including HIPAA

• Discusses the replacement of legacy systems

• Provides case studies of PACS implementation ina clinical healthcare system and an academicinstitution

Selected Contents:

PACS Servers and Workstations. Imaging DisplayDevices in PACS. Networking Technologies. DataStorage. Healthcare Information Integration.Teleradiology. Practical PACS Implementation.Upgrade and Replacing Legacy PACS. EnterprisePACS. Electronic Health Record and Personal HealthRecord Implementation. Quality Control, Security,and Downtime Management. Index.

Catalog no. C8365, November 2010, 367 pp.ISBN: 978-1-4200-8365-1, $145.95 / £93.00Also available as an eBook





CorrectionTechniques inEmissionTomographyEdited by

Mohammad Dawood,Xiaoyi Jiang, and Klaus SchäfersEuropean Institute for MolecularImaging, Münster, Germany

“It is refreshing to have a text on emission molecularimaging relevant to animals and human beings withan emphasis on those factors that detract from res-olution and quantification. This book implicitly dis-tinguishes between molecular imaging of emittersand molecular imaging provided by magnetic reso-nance techniques … In sum, this book shows howresearchers have overcome limitations in emissiontomography noted 40 years ago and have broughtthe methods to the goal of high spatial resolutionand quantification. Most importantly, theseadvances have enabled clinically useful applicationsnot available to other diagnostic methods.”—From the Foreword by Thomas F. Budinger, University of

California, Berkeley

• Provides a thorough treatment of state-of-the-artcorrection techniques

• Covers different imaging modalities, includingnuclear medicine imaging, hybrid systems, andoptical imaging

• Addresses the special problems encountered inhybrid imaging

• Explores the use of correction methods in bio-medical imaging applications

Selected Contents:

BACKGROUND: Biomedical Applications of EmissionTomography. PET Image Reconstruction. CORREC-TIONS TECHNIQUES IN PET AND SPECT: Basics ofPET and SPECT Imaging. Corrections for PhysicalFactors. Corrections for Scanner Related Factors.Image Processing Techniques in EmissionTomography. Motion Correction in EmissionTomography. Combined Correction andReconstruction Methods. RECENT DEVELOPMENTS:Introduction into Hybrid Tomographic Imaging. MR-Based Attenuation Correction for PET/MR. OpticalImaging. Index.

Catalog no. K10659, April 2012, 287 pp.ISBN: 978-1-4398-1298-3, $119.95 / £76.99Also available as an eBook

TheoreticalFoundations of DigitalImaging UsingMATLAB®

Leonid P. YaroslavskyTel Aviv University, Israel

Helping readers master digital imaging, this text pres-ents a unified theoretical basis for understanding anddesigning methods of imaging and image processing.Designed for newcomers to imaging science andengineering, the book treats the theory of digitalimaging as a specific branch of science, covering thesubject in its entirety—from image formation toimage perfecting. The author avoids using heavymathematics and derives all formulas in full detail. Tofacilitate a deeper understanding of the major results,the book includes a number of exercises supported byMATLAB® programs, with the code available on thebook’s CRC Press web page.

• Emphasizes the connection between the originalanalog nature of images and image transforma-tions and their computer implementation

• Supports all mathematical formulations by theirphysical interpretation

• Avoids using heavy mathematics

• Derives all formulas in full detail without skip-ping intermediate steps

• Supports concepts and algorithms with interac-tive MATLAB exercises at the end of each chap-ter

• Provides downloadable MATLAB files for theexercises at www.crcpress.com

Selected Contents:

Introduction. Mathematical Preliminaries. ImageDigitization. Discrete Signal Transformations. DigitalImage Formation and Computational Imaging.Image Resampling and Building Continuous ImageModels. Image Parameter Estimation: Case Study—Localization of Objects in Images. Image Perfecting.Index.

Catalog no. K12836, November 2012, c. 511 pp.ISBN: 978-1-4398-6140-0, $99.95 / £63.99Also available as an eBook



25

Also of Interest


An Introductionto RadiationProtectionSixth EditionAlan Martin, Sam Harbison, Karen Beach, and Peter Cole

“Overall, the sixth edition maintains the high stan-dards of its predecessors and should remain as a keyreference text for those working in radiation protec-tion.”

—Journal of Radiation Protection

The sixth edition of this established text takes readersthrough the general background of the subject, thetechnical principles underlying the control of radiationhazards, radiation detection and measurement, andthe biological effects of radiation. The book alsoaddresses radiation protection issues in the nuclearindustry, the non-nuclear sector, and the medicalfield. Further specialized topics include risk assess-ment, waste management and decommissioning,radiological incidents and emergencies, relevant legis-lation, and organizational issues.

• Incorporates clear diagrams and photographs aswell as summary sections and revision questionsthat are suitable for beginners and moreadvanced radiation practitioners

• Reflects current EU strategies and otherEuropean and international requirements andlegislation, including ICRP103

• Covers more risk and risk assessment, decom-missioning, and recent advances in radiationprotection in medicine

• Includes an image library and sample lectures

Selected Contents:

The Structure of Matter. Radioactivity and Radiation.Radiation Units. Biological Effects of Radiation.Natural and Man-Made Radiation. The System ofRadiological Protection. Radiation Detection andMeasurement. The External Radiation Hazard. TheInternal Radiation Hazard. Practical Health PhysicsTechniques. Radiation Protection in the NuclearIndustry. Radioactive Waste and theDecommissioning of Radioactive Facilities. …

Catalog no. K18600, March 2012, 256 pp.Soft Cover, ISBN: 978-1-4441-4607-3$52.95 / £32.99

Introduction to BioMEMSAlbert FolchUniversity of Washington,Seattle, USA

“The field has been waiting for a true textbook thatprovides a practical, historical, authoritative, andcomprehensive introduction to bioMEMS. It hasfinally arrived, courtesy of Albert Folch, completewith PowerPoint lectures and thoughtful homeworkquestions. I highly recommend it.”

—David J. Beebe, University of Wisconsin–Madison

“A comprehensive, colorful textbook on the impor-tant field of bioMEMS. I will definitely recommend tomy students!”

—Albert van den Berg, University of Twente

“Dr. Folch’s book is a monumental achievementwhich brings an authoritative and comprehensiveaccount to the rapidly growing, multidisciplinaryfield of bioMEMS. Many working scientists and engi-neers as well as students will find this book fascinat-ing.”

—Mehmet Toner, Harvard Medical School

“This book successfully integrates microfabricationand the physics of microfluidics with numerous bio-logical applications. It provides a visual feast ofimages that lead to a comprehensive understandingof many complex concepts. Applications presentedrange from biomolecules to cells, tissues, and organ-isms, and are presented in clear, logical steps. Itserves as an outstanding text for advanced under-graduates and graduate students, as well as anexcellent review for researchers who are new to thefield.”

—Fawwaz Habbal, Harvard University

Selected Contents:

How Do We Make Small Things? Micropatterning ofSubstrates and Cells. Microfluidics. Molecular Biologyon a Chip. Cell-Based Chips for Biotechnology.BioMEMS for Cell Biology. Tissue Microengineering.Implantable Microdevices. Appendix. Index.

Catalog no. K10966, August 2012, 528 pp.ISBN: 978-1-4398-1839-8, $89.95 / £57.99Also available as an eBook




Also of Interest

Basic ClinicalRadiobiologyFourth EditionEdited by

Michael C. JoinerAlbert van der KogelRadboud University MedicalCenter, Nijmegen, Netherlands

This book deals with the biological aspects of radio-therapy. It presents the main ideas and significant sci-entific developments that underlie the radiotherapeu-tic management of cancer. New chapters in this edi-tion cover the mechanisms of cell death, biologicalresponse modifiers, and biological image-guidedradiotherapy. This edition also revises sections on themolecular basis of the radiation response, tumorhypoxia, and the dose-rate effect.

Selected Contents:

Introduction: The Significance of Radiobiology andRadiotherapy for Cancer Treatment. Irradiation-Induced Damage and the DNA Damage Response.Cell Death after Irradiation: How, When and WhyCells Die. Quantitating Cell Kill and Cell Survival.Models of Radiation Response. Dose-ResponseRelationships in Radiotherapy. LET and RBE. TumorGrowth and Response to Radiation. Fractionation:The L-Q Approach. The L-Q Approach in ClinicalPractice. Modified Fractionation. Time Factors inNormal Tissue Response to Radiation. The Dose-RateEffect. Pathogenesis of Normal Tissue Side Effects.The Volume Effect in Radiotherapy. The OxygenEffect and Fractionated Radiotherapy. The TumorMicroenvironment and Cellular Hypoxia Responses.Therapeutic Approaches to Tumor Hypoxia.Combined Radiotherapy and Chemotherapy.Retreatment Tolerance of Normal Tissues. MolecularImage-Guided Radiotherapy with PET. Molecular-Targeted Agents for Enhancing Tumor Response.Biological Response Modifiers in the Clinic: Tumor.Biological Response Modifiers: Normal Tissue.Molecular Targeting and Patient Individualization.Protons and Other Ions in Radiotherapy. SecondCancers after Radiotherapy.

Catalog no. K18393, March 2009ISBN: 978-0-340-92966-7, $68.95 / £42.99Also available as an eBook

Introduction toExperimentalBiophysicsBiological Methods for Physical ScientistsJay NadeauMcGill University, Montreal,Quebec, Canada

“This book is essential reading for any physical sci-entist who is interested in performing biologicalresearch.”

—Contemporary Physics

“… an ambitious text aimed at educating new grad-uate students about the important and most com-mon techniques used in a modern biological physicslaboratory; it could also serve nicely as a referencemanual for advanced graduate students of new orunderused protocols. … an essential part of the bio-physicist’s collection.”

—Jennifer L. Ross, Physics Today, August 2012

“The book provides a comprehensive overview ofdiverse methods in biophysics. It will be a greatresource for every working scientist in the physicalsciences. It would also be a great supporting text toread as part of an introductory course in biophysicalmethods, particularly for graduate students andpostdocs entering the field from other disciplines.”

—Anthony J. Koleske, Yale University

This text is a practical companion for physical scien-tists seeking to move into wet laboratory experimentsand biological research areas. The book’s three mainsections address genes, proteins, and expression sys-tems. This structure allows readers to follow the stepsinvolved in the production of nucleic acids and pro-teins and the different levels of purification requiredfor each type of analysis.

Selected Contents:

Introduction and Background. Molecular Cloning ofDNA and RNA. Expression of Genes in Bacteria,Yeast, and Cultured Mammalian Cells. ProteinExpression Methods. Protein Crystallization.Introduction to Biological Light Microscopy.Quantitative Cell Culture Techniques. SemiconductorNanoparticles (Quantum Dots). Gold Nanoparticles.Surface Functionalization Techniques.Electrophysiology. Spectroscopy Tools andTechniques. Appendix. Glossary. Index.

Catalog no. K11452, September 2011, 672 pp.Soft Cover, ISBN: 978-1-4398-2953-0$93.95 / £59.99Also available as an eBook



CRC PressTaylor & Francis Group

Catalog no. K12085December 2012, 908 pp.ISBN: 978-1-4398-4652-0

$595.00 / £379.00Also available as an eBook

Get the Most Up-to-DateEncyclopaedia on Medical Physics

➢ Contains roughly 3,500 cross-referenced entries relating tomedical physics and associatedtechnologies—split into two volumes

➢ Co-published by the EuropeanMedical Imaging Technology e-Encyclopaedia for LifelongLearning (EMITEL) consortium

➢ Supported by the InternationalOrganization for Medical Physics(IOMP)

➢ Features contributions from over100 specialists

➢ Describes new and existing methods and equipment in medical physics

➢ Includes references, further reading, images, graphs, formulas, and examples

Encyclopaedia of Medical PhysicsTwo-Volume Set

Edited by

Slavik Tabakov, Franco Milano, Sven-Erik Strand, Cornelius Lewis, and Perry Sprawls

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