Medicinal Chemistry

Dr H. ReddyWMH

Opioids

LA

NDMR

Barb’s

BZD’s

S tructure A ctivity R elationship

Common viva Qns…

• What is organic chemistry?

• Explain the meaning / relevance of SAR?

• Compare various drug groups and explain how their SAR affect their physicochemical properties?

• How would you design a drug?

Symbol

Name

A No.

A Mass

Symbol

Name

A No.

A Mass

Number of PROTONS

Number of PROTONS & NEUTRONS

IONIC bonds

COVALENT bonds

METALLIC bonds

VAN DER WAALS forces

DIPOLE-DIPOLE bond

HYDROGEN bonds

Basic building blocks

ESSENTIAL

Phenylalanine Valine

Threonine Tryptophan Methionine

Leucine Isoleucine

Lysine Histidine

CONDITIONAL

Arginine Cysteine Glycine

Glutamine Proline

Tyrosine

DISPENSABLE

Alanine Aspartic acid Asparagine

Glutamic acid Serine

9 6 5

CATECHOL-Ethylamine

CATECHOL-Ethylamine

αβ

A lpha binds A mine group

Barbiturates

R Imino group

BENZO-DIAZEPINEs

BENZO-DIAZEPINEs

Benzene

Diazepine

NDMR (Bis-Benzyl-isoquinolinium)

NDMR (Bis-Benzyl-ISOQUINOLINIUM)

ESTER

ESTER

Mivacurium

NDMR (amino-steroids)

NDMR (amino-STEROIDs)

3

17

Suggammadex

DMR

Opi-ates / -oids

PHENOL

3

6

Inhalation agents

Local anaesthetics

Questions???