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Combines cells,
engineering, biology,
and medicine
Repairs or replaces part
of or whole tissues
It will likely revolutionize
the world
Provides temporary support
Purposes:1. Allows cells to attach
and then transfer2. Allows for the vital
cell nutrients to diffuse
3. Make use of some mechanical and biological influences
Important both in vitro and ex vitro
Needs to be biodegradable and flexible especially for a heart
Picture used specifically for heart repair
Autologous cells are obtained and placed into the bioreactor
Scaffold is then covered with the new cells
The scaffold is then transplanted into the body
Ratner, a UW professor of bioengineering
Ratner built a new and different scaffold that will be injected the heart.
The scaffold supports and regulates the muscle growth.
In the future, the procedure would be done before scar tissue forms.
Many more heart scaffold and tissue patches are being developed.
Others can involve different types of cells along with the cardiac muscles and are much more expensive.
He found that it took 4 weeks for the scaffold to degrade.
Heart cells in a culture dish do not have a blood supply.
Therefore getting blood to those cells immediately is essential.
Size of scaffold implanted – 1/3 of a mm wide by 4 mm long
Resources 1. "Scaffolding for Heart Stem Cells after a Heart Attack." The Daily
Heart Beat — Reliable Information and Commentary by a Doctor/Heart Attack Survivor. Web. 7Nov. 2011. <http://heartcurrents.com/scaffolding-heart-stem-cells-heart-attack/>.
2. Tissue Engineering and Wound Healing: An Overview: History of Tissue Engineering. Health Management Publications, Inc., 2007. Web. 2011.
3. Davis, Ph.D., Kevin. "Advances in Cardiac Tissue Engineering and Cardiac Tissue Replacement Modalitie." Tissue Engineering. By Scott Seidman. 2002. Web. 8 Nov. 2011.
<http://sa.rochester.edu/jur/issues/fall2003/krebs.pdf>.
2. "Heart Transplants: Statistics." American Heart Association. Web. 18 Feb. 2011. <http://www.americanheart.org/presenter.jhtml?identifier=4588>.
5. "NIH Definition of Tissue Engineering/Regenerative Medicine." Tissue-Engineering. Web. 8 Nov. 2011. <http://www.tissue-engineering.net/index.php?seite=whatiste>