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Breakout session: Meningococcal Vaccines
Break-out--Hepatitis B.pptx
What are the different serotypes prevalent globally?
Epidemiology in India
• IAPCOI does not recommend meningococcal vaccination to all children. It is recommended only for High risk individuals. What is the rationale of this?
• What is the epidemiology of meningococcal infections in India? A. Endemic B. SporadicC. Occurs only as outbreaksD. Sporadic with outbreaks
What are the various meningococcal vaccines available ?
Meningococcal Vaccines
Purified capsular polysaccharide vaccines
Bivalent vaccine against serogroups A and C
Quadrivalent vaccine for serogroups A,C, Y and W135
Protein-polysaccharide conjugate vaccines.
Three monovalent meningococcal C conjugate vaccines (Not
available in India)
Two quadrivalent conjugate vaccine (ACYW135) (Menactra
& Menveo--Not available in India)
Conjugate vaccines may be a better choice when
available in India
Why is there no vaccine against serogroup B at present?
What are target groups for routine meningococcal vaccination in India ?
IAPCOI- High Risk
• Age -children > 2 yrs (> 3 months if risk e.g. outbreaks/ contacts , children with terminal complement component deficiencies.
• Children with functional/ anatomic asplenia/ hyposplenia (vaccination 2 weeks prior to splenectomy)
• Laboratory personnel
• Travelers to Saudi Arabia for Haj
• Travelers to the African meningitis belt particularly between Dec to June
• Adjunct to chemoprophylaxis in close contacts
• Students going for study abroad
Scenario
• Many cases of Meningococcal meningitis reported from Delhi. How many cases make it an outbreak ?
• Should meningococcal vaccine be given to all the children? What is the role of meningococcal vaccine during outbreaks? Which vaccine can be used?
• What is the role of ‘mass chemoprophylaxis’ during an outbreak situation?
Case 1
• Nine-mo-old Ishan is hospitalized with meningitis and the doctors say it is meningococcal meningitis.
• Should his 4 y sister be administered meningococcal vaccine ?
Case 2
• Arnav is going for higher studies to Imperial University, London, UK. The university form asks if meningococcal vaccine has been administered.
• What vaccine should be given to him and how many doses?
• Can he take it just a day prior to his departure ?
Case 3
• Suhas, 8 years, has recently shifted to US with his parents. He has already received a dose of quadrivalent conjugate meningococcal vaccine one year earlier.
• Should he need to take another dose of the meningococcal vaccine?
• What are the current recommendations of CDC/ACIP on booster dose of conjugate meningococcal vaccines?
ACIP recommended schedule & interval
Case 4
• A concerned parent from Delhi visits your clinic and enquires about meningococcal disease, its seriousness and prevention in v/o death of his adolescent relative during Delhi epidemic in 2006-07
• How will you counsel him?
Case 5
• The parents of a 15 yrs old girl who came to you for HPV vaccination enquires about meningococcal vaccination since she is planning to go to a hostel in NE region, particularly in v/o a recently occurred mini-outbreak in Mizoram. She is also in constant contact with her 5 yrs old splenectomized brother.
• How will you counsel them?