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Metabolic - Imperial College Londonshm/Papers/metabduce.pdf ·

Date post: 23-Aug-2019
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Metabolic

diagrams

(KEGG)

-1

-0.8

-0.6

-0.4

-0.2

0

0.2

0.4

0.6

8 32 56 80 104

NMR spectrometer

NMR spectra

Concentrations of

Metabolites

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Isocitrate

NMND Citrulline

Ornithine

Acryloyl−CoA

Arginine

L−Lysine

UreaFormaldehyde

Methylamine

Lactate

L−AS

TaurineSuccinate

Citrate

Hippurate

Beta−Alanine

Creatine

Creatinine

2.6.1.39 ; 4.2.1.36; ...

1.1.1.42; 4.2.1.3; ...

1.3.99.1; 1.3.5.1

2.3.3.1; 4.2.1.2; ...

4.2.1.3; 5.3.3.7

4.4.1.12; 2.6.1.55; ...

1.2.1.31; 1.5.1.7; ...

4.1.1.20; 5.1.1.7;...

2.3.3.1; 2.6.1.14; ...

1.13.11.16; 1.14.13.4; ...1.5.1.13; 2.1.1.1; ... 1.5.1.13 ;2.1.1.7;...

1.1.99.8; 1.2.1.46; ...

4.3.2.1 6.3.4.5

3.5.3.1

3.5.2.10

2.1.3.1; 1.3.99.3;...

4.3.1.6

4.1.2.32

2.1.1.2;2.1.4.1;...

2.8.3.1; 4.2.1.54

1.4.99.3;2.1.1.21;...

L−2−aminoadipate

2−oxo−glutarate

Sarcosine 3.5.3.3

3.5.1.59;3.5.2.14;...

1.5.99.1

4.2.1.3

TMAO

2.3.1.61; 3.1.2.3; ...trans−aconitate

Fumarate

NMNA

Formate

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of inhibited enzyms ABDUCTION INDUCTION

of inhibition rules

inhibits(h,E):− class(E,ec1), cofact(E,...),..

down(m1).up(m2)...

down(X):− reaction(X,E,Y), inhibited(E,Y,X),...

inhibits(h,e8).inhibits(h,e9)...

inhibited(e1,m2,m1).not inhibited(e3,...)...

reaction(m1,e1,m2).reaction(m3,e2,m4)...

observables abducibles

NMR

KEGG BRENDA

examples

BACKGROUND KNOWLEDGE

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50

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60

65

70

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60

65

70

75

80

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Pred

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No. of training examples

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