CURRICULUM VITAE 1 | Page MICHAEL LA FRANO, PHD, RD Assistant Professor Food Science and Nutrition Department California Polytechnic State University, San Luis Obispo Work Address California Polytechnic State University Building 11, Room 225 1 Grand Ave San Luis Obispo, CA 93407 office phone: (805) 756-6233 fax phone: (530) 752-5295 e-mail: [email protected]Academic Training: Ph.D., Nutritional Biology Thesis: Metabolism of Biologically Active Retinoids and Provitamin A Carotenoids in Humans and Animal Models University of California, Davis, 11/2012. (Mentor: Burri B.J.) B.S., Nutrition & Dietetics Registered Dietitian License Loma Linda University, Loma Linda, CA. 06/2007. (Advisors: Connell B. and Kosch C.) Work Experience: Sep 2016 – Present: Assistant Professor, Food Science and Nutrition Department, California Polytechnic State University, San Luis Obispo. Jun 2013 – Sep 2016: Postdoctoral researcher and Pilot & Feasibility Project Scientist, NIH West Coast Metabolomics Center, Lipid Mediators Core, Department of Nutrition, University of California, Davis: Management of NIH Pilot & Feasibility Projects involving targeted metabolomics to investigate disease, as well as method development for the West Coast Metabolomics Center. (Mentor: Newman, J.W.) May 2013 – Oct 2013: Consultant, HarvestPlus c/o International Food Policy Research Initiative, Washington, D.C.: Review of the bioavailability of provitamin A carotenoids, iron, and zinc in conventionally-bred biofortified staple foods. Feb 2012 – June 2013: GS-6 Biological Science Technician, USDA, Agricultural Research Service, Western Human Nutrition Research Center. Davis, CA: Investigation of retinoid and provitamin A carotenoid metabolism.
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MICHAEL LA FRANO, PHD, RD Assistant Professor Food Science and Nutrition Department California Polytechnic State University, San Luis Obispo Work Address California Polytechnic State University Building 11, Room 225 1 Grand Ave San Luis Obispo, CA 93407 office phone: (805) 756-6233 fax phone: (530) 752-5295 e-mail: [email protected] Academic Training: Ph.D., Nutritional Biology Thesis: Metabolism of Biologically Active Retinoids and Provitamin A Carotenoids in Humans
and Animal Models University of California, Davis, 11/2012. (Mentor: Burri B.J.) B.S., Nutrition & Dietetics Registered Dietitian License Loma Linda University, Loma Linda, CA. 06/2007. (Advisors: Connell B. and Kosch C.) Work Experience: Sep 2016 – Present: Assistant Professor, Food Science and Nutrition Department, California
Polytechnic State University, San Luis Obispo. Jun 2013 – Sep 2016: Postdoctoral researcher and Pilot & Feasibility Project Scientist, NIH
West Coast Metabolomics Center, Lipid Mediators Core, Department of Nutrition, University of California, Davis: Management of NIH Pilot & Feasibility Projects involving targeted metabolomics to investigate disease, as well as method development for the West Coast Metabolomics Center. (Mentor: Newman, J.W.)
May 2013 – Oct 2013: Consultant, HarvestPlus c/o International Food Policy Research Initiative, Washington, D.C.: Review of the bioavailability of provitamin A carotenoids, iron, and zinc in conventionally-bred biofortified staple foods.
Feb 2012 – June 2013: GS-6 Biological Science Technician, USDA, Agricultural Research Service, Western Human Nutrition Research Center. Davis, CA: Investigation of retinoid and provitamin A carotenoid metabolism.
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May 2011 – Sep 2011: Graduate Student Researcher, Department of Nutrition, University of California, Davis: Investigation of retinoid and provitamin A carotenoid metabolism.
Jul 2009 – Sep 2009; Feb 2010 – May 2010: GS-5 Biological Science Technician, USDA, Agricultural Research Service, Western Human Nutrition Research Center. Davis, CA: Investigation of retinoid and provitamin A carotenoid metabolism. (Mentor: Burri, B.J.)
Sep 2008 – Jun 2010: Graduate Student Teaching Assistant, Department of Nutrition, University of California, Davis: Clinical Nutrition Series (NUT 116A & B), Principles of Quantity Food Production (FSM 120), Quantity Food Production Laboratory (FSM 120L)
Internships: Sep 2005 – Jun 2007: Dietetic intern, Loma Linda University Medical Center, Loma Linda, CA:
Clinical and public health application of Nutrition & Dietetics at the Loma Linda University Medical Center, Diabetes Treatment Center, and Kidney Center.
Jul 2005 – Aug 2006: Dietetic intern, Valley Unified School District, Moreno Valley, CA: Administrative application of Nutrition & Dietetics for the evaluation and conduction of the school lunch program.
Summary of Research Experience: • Specializations:
metabolomics, aminomics, and lipidomics) and polyphenols HPLC/DAD – quantitative analysis of fat-soluble vitamins (including
retinoids) and cis- and trans-carotenoids. HPLC/ECD – quantitative analysis of carotenoids and fat-soluble vitamins
(including retinoids) Ultracentrifugation – separation of plasma lipoprotein layers Solid phase & phospholipid removal 96-well extraction plates – elution of
plasma, media, and tissue oxylipins, monoacylglycerols and acylethanolamides (including endocannabinoids), and sphingoid bases (including ceramides) and bile acids
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Liquid:liquid extraction – polar and non-polar metabolomics assay compounds, fat-soluble vitamins, and carotenoid separation from biological tissues, urine, feces, blood, plasma, breast milk, plants, and food
In vitro digestion models – bioaccessibility of carotenoids in foods • Instrumental techniques:
HPLC: DAD, ECD UPLC: DAD, MS/MS GC: MS 96-well plate protein precipitation, solid phase, and phospholipid removal
extraction • Metabolic Network Mapping utilizing Cytoscape and Cmap • Multivariate data analysis using R, JMP, imDEV, DeviumWeb, and Metaboanalyst in the
context of targeted and untargeted metabolomics
Funding and Grant Support: 1. Title: Metabolism of the provitamin A carotenoid β-cryptoxanthin in the Mongolian gerbil:
Absorption, tissue distribution, and dose-response assessment. (PI: B.J. Burri, USDA-ARS-WHNRC)
Dates: 9/2008 – 9/2012 (completed) Goal: The purpose of the study was to gain insight into the whole body metabolism of β-
cryptoxanthin in the gerbil. The objectives were to test 14 tissues and blood, urine, and feces of Mongolian gerbils fed 3 different concentrations of β-cryptoxanthin, to identify locations of interest, and the effect of dosage on the distribution of β-cryptoxanthin.
Role: Study manager - Conducted feeding study of gerbils, collected biological tissues and blood, designed the analysis protocol, analyzed retinoid/carotenoid in tissue and feed. Conducted statistical analysis, interpreted results, and wrote manuscript. One article was published with me as first author.
Funding: USDA Intramural project: 5360-51530-018-23T; Henry A. Jastro Research Scholarship
2. Title: Bioavailability and bioconversion of beta-carotene-biofortified cassava in American
women (PI: B.J. Burri, USDA-ARS-WHNRC; Co-PI: M.R. La Frano, USDA-ARS-WHNRC) Dates: 11/2010 – 02/2015 (completed) Goal: Estimate the effectiveness of biofortified cassava for increasing provitamin A
carotenoid and vitamin A concentrations in healthy adult women; and to determine whether increased fat in the diet improved these concentrations.
Role: Co-PI and study manager - Coordinated professors, technicians, nurses, recruiters, and kitchen workers to conduct the study. Developed a method for the separation of the triacylglycerol-rich lipoprotein particles and optimized an HPLC-based electrochemical detection for identifying retinoids and carotenoids. Conducted statistical analysis, interpreted results, and wrote manuscript. In a follow-up study, I served as Co-PI as we assessed the vitamin A bioconversion efficiency of biofortified
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cassava gari and red palm oil. Three articles have been published with me as first author on one. An additional manuscript is under review with me as corresponding author.
Funding: HarvestPlus grant #8227; USDA Intramural project: 5360-51530-018-23T; National Center for Research Sources grant #2UL1RR024146
3. Title: Utilization of calibration and internal standards for the quantitation of nutrients in
foods and metabolites in the body (PI: M.R. La Frano, Dept. of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo)
Dates: 6/2017 – 6/2018 (completed) Goal: Develop methods for both targeted metabolomics analysis to investigate the role of
lipid mediators in nutrition and disease, and conduct nutrient analysis of carotenoids, polyphenols, and fat soluble vitamins in order to assess the nutritional quality and sensory characteristics of or processing effects on food
Role: As PI my role is to develop extraction and UPLC-MS/MS methods to analyze nutrients and metabolites. I will prepare standards and conduct method validation using HHS FDA procedures.
Funding: Agricultural Research Institute grant 4. Title: Effect of probiotic and high fructose supplementation in pediatric NAFLD and early
weaning pigs (PI: R. Manjarin, Dept. of Animal Science, California Polytechnic State University, San Luis Obispo)
Dates: 6/2017 – present Goal: Compare the impact of prolonged high-fructose intake vs. high fructose
supplemented with probiotics vs. control on NAFLD in neonates, and to identify the mechanisms involved in the pathogenesis of the disease.
Role: As a collaborator, my role is to assist in the study design and method development. I will be conducting primary metabolomics, aminomics, and lipidomics analysis in liver tissue and plasma. Consequently, I will conduct the data processing, statistical analysis, interpretation of results, and manuscript writing.
Funding: BiOWiSH Technologies, Agricultural Research Institute grant
5. Title: Strawberries and Health: Is the way to the heart through the gut? (PI: K. Pilolla, Dept. of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo; Co-PI: M.R. La Frano, Dept. of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo)
Dates: 6/2017 – present Goal: Identify changes in complex lipids associated with heart disease and xenobiotics
associated with guy health from consumption of strawberries. Role: As Co-PI, my role is to assist in study design and conduction, conduct the data
processing, statistical analysis, interpretation of results, and manuscript writing after the analysis of bile acids and polyphenols in plasma. Measure polyphenol content and bioavailability.
Funding: California Strawberry Commission, Agricultural Research Institute grant
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6. Title: Utilization of metabolomics analyses to investigate biomarkers of gestational
diabetes mellitus (PI: M.R. La Frano, Dept. of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo)
Dates: 6/2017 – present Goal: Identify gestational diabetes biomarkers in plasma collected during first trimester
and third trimester of pregnant women prior to diagnosis of gestational diabetes. Role: As PI my role is to analyze the primary metabolomics, aminomics, and lipidomics
profile in plasma. In addition, I will direct data processing, statistical analysis, interpretation of results, and manuscript writing.
Funding: Agricultural Research Institute grant (NIH R01 matching)
7. Title: Novel strategies to improve efficiency of dietary protein utilization in lactation (PI: R. Manjarin, Dept. of Animal Science, California Polytechnic State University, San Luis Obispo)
Dates: 6/2018 – present Goal: Compare the impact of prolonged high-fructose intake vs. high fructose
supplemented with probiotics vs. control on NAFLD in neonates, and to identify the mechanisms involved in the pathogenesis of the disease.
Role: As a collaborator, my role is to assist in the study design and method development. I will be conducting primary metabolomics, aminomics, and lipidomics analysis. Consequently, I will conduct the data processing, statistical analysis, interpretation of results, and manuscript writing.
Funding: BiOWiSH Technologies, Agricultural Research Institute grant
8. Title: Effectiveness of Pre-pregnancy Lifestyle Intervention for Preventing Recurrent Gestational Diabetes via improvements in Metabolic Markers of Health (PI: M.R. La Frano, Dept. of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo)
Dates: 6/2018 – present Goal: Assess the impact of a pre-conception lifestyle intervention, including diet, exercise,
and behavior modification, on gestational diabetes recurrence. Role: As PI my role is to analyze a metabolomics, aminomics, and lipidomics profile. In
addition, I will direct data processing, statistical analysis, interpretation of results, and manuscript writing.
Funding: Agricultural Research Institute grant (NIH R01 matching)
9. Title: Assessment of neurodegeneration in a pig model of non-alcoholic fatty liver disease (PI: M. Maj, Dept. of Biological Sciences, California Polytechnic State University, San Luis Obispo; Co-PI: M.R. La Frano, Dept. of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo)
Dates: 6/2018 – present Goal: Assess the impact of high-fructose and high fat intake on NAFLD in pig neonates on
brain structure and metabolism.
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Role: As Co-PI my role is to analyze the primary metabolomics, aminomics, and lipidomics profile. In addition, I will direct data processing, statistical analysis, interpretation of results, and manuscript writing.
Funding: Research, Scholarly, and Creative Activities (RSCA) Grant
10. Title: Maternal Hypoxemia and Oxidative Stress in the Fetus, Newborn, and Adult (PI: Sean Wilson, Dept. of Medicine, Loma Linda University)
Dates: 11/2018 – present Goal: Investigate the influence of LTH on plasma biomarkers in metabolomic and proteomic samples from fetal, newborn and adult sheep.
Role: As collaborator my role is to statistically analyze the metabolomics data. In addition, I will assist in the interpretation of results and manuscript writing.
Funding: NIH R03 grant
11. Title: Randomized trial evaluating oral consumption of bisphenol A on insulin sensitivity (PI: Todd Hagobian, Dept. of Kinesiology and Public Health, California Polytechnic State University, San Luis Obispo; Co-PI: M.R. La Frano, Dept. of Food Science and Nutrition, California Polytechnic State University, San Luis Obispo)
Dates: 1/2019 – present Goal: Assess the impact of bisphenol A intake on parameters of insulin sensitivity.
Role: My role as Co-I is to perform LC-MS analysis of urinary bisphenols and plasma labeled glucose. In addition, I will assist in the interpretation of results and manuscript writing.
Funding: American Diabetes Association grant Professional Service: Editor: Frontiers Nutr Ad hoc manuscript reviewer: Metabolomics, J Proteome Res, Nutr Rev, Mol Biotechnol, J
Agric Food Chem, Am J Physio, Eur J Clin Nutr, J Nutr, Curr Dev Nutr, Diabetes
Teaching Experience: 1. Teaching Assistant – Clinical Nutrition (NUT116A), 2008 Fall Quarter: Instructor of record –
Dr. Francene M. Steinberg, Dept. of Nutrition, University of California, Davis. 2. Teaching Assistant – Clinical Nutrition (NUT116B), 2009 Winter Quarter: Instructor of
record – Dr. Andrew J. Clifford, Dept. of Nutrition, University of California, Davis. 3. Teaching Assistant – Quantity Food Production (FSM 120L), 2009 Spring Quarter: Instructor
of record – Nancy Hudson, Dept. of Nutrition, University of California, Davis. 4. Teaching Assistant – Quantity Food Production (FSM 120L), 2009 Fall Quarter: Instructor of
record – Nancy Hudson, Dept. of Nutrition, University of California, Davis.
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5. Teaching Assistant – Principles of Quantity Food Production (FSM 120), 2010 Winter Quarter: Instructor of record – Nancy Hudson, Dept. of Nutrition, University of California, Davis.
6. Teaching Assistant – Quantity Food Production (FSM 120L), 2010 Spring Quarter: Instructor of record – Nancy Hudson, Dept. of Nutrition, University of California, Davis.
7. Instructor of record – Nutrient Metabolism II (FSN 329) lecture, 2016 Fall Quarter, California Polytechnic State University, San Luis Obispo
8. Instructor of record – Human Nutrition (FSN 210), 2016 Fall Quarter, California Polytechnic State University, San Luis Obispo
9. Instructor of record – Nutrient Metabolism II (FSN 329) lecture, 2017 Winter Quarter, California Polytechnic State University, San Luis Obispo
10. Instructor of record – Human Nutrition (FSN 210), 2017 Winter Quarter, California Polytechnic State University, San Luis Obispo
11. Instructor of record – Metabolic and Molecular Aspects of Vitamins (FSN 529), 2017 Winter Quarter, California Polytechnic State University, San Luis Obispo
12. Instructor of record – Nutrient Metabolism II (FSN 329) lecture, 2017 Spring Quarter, California Polytechnic State University, San Luis Obispo
13. Instructor of record – Human Nutrition (FSN 210), 2017 Spring Quarter, California Polytechnic State University, San Luis Obispo
14. Instructor of record – Human Nutrition (FSN 210), 2017 Fall Quarter, California Polytechnic State University, San Luis Obispo
15. Instructor of record – Nutrient Metabolism II (FSN 329) lecture, 2017 Fall Quarter, California Polytechnic State University, San Luis Obispo
16. Instructor of record – Nutrient Metabolism II (FSN 329) lecture, 2018 Winter Quarter, California Polytechnic State University, San Luis Obispo
17. Instructor of record – Nutrient Metabolism II (FSN 329) laboratory, 2018 Winter Quarter, California Polytechnic State University, San Luis Obispo
18. Instructor of record – Nutrient Metabolism II (FSN 329) lecture, 2018 Spring Quarter, California Polytechnic State University, San Luis Obispo
19. Instructor of record – Nutrient Metabolism I (FSN 328), 2018 Fall Quarter, California Polytechnic State University, San Luis Obispo
20. Instructor of record – Nutrient Metabolism II (FSN 329) lecture, 2018 Fall Quarter, California Polytechnic State University, San Luis Obispo
21. Instructor of record – Nutrient Metabolism II (FSN 329) laboratory, 2018 Fall Quarter, California Polytechnic State University, San Luis Obispo
22. Instructor of record – Nutrient Metabolism II (FSN 329) lecture, 2019 Winter Quarter, California Polytechnic State University, San Luis Obispo
23. Instructor of record – Senior Project (FSN 461) lecture, 2019 Winter Quarter, California Polytechnic State University, San Luis Obispo
24. Instructor of record – Nutrient Metabolism II (FSN 329) lecture, 2019 Spring Quarter, California Polytechnic State University, San Luis Obispo
25. Instructor of record – Metabolic and Molecular Aspects of Vitamins (FSN 529), 2019 Spring Quarter, California Polytechnic State University, San Luis Obispo
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26. Instructor of record – Nutrient Metabolism II (FSN 329) lecture, 2019 Fall Quarter, California Polytechnic State University, San Luis Obispo
27. Instructor of record – Senior Project (FSN 461) lecture, 2019 Fall Quarter, California Polytechnic State University, San Luis Obispo
28. Instructor of record – Nutrient Metabolism II (FSN 329) lecture, 2020 Winter Quarter, California Polytechnic State University, San Luis Obispo
29. Instructor of record – Micronutrient Metabolism (FSN 332) lecture, 2020 Winter Quarter, California Polytechnic State University, San Luis Obispo 30. Instructor of record – Senior Project (FSN 461) lecture, 2020 Winter Quarter, California
Polytechnic State University, San Luis Obispo Speaking Engagements or Session Chair/Leader: 1. Session leader – University of California, Davis West Coast Metabolomics Center
International Summer Sessions in Metabolomics: Procedures for targeted analytics. September 2014.
2. Invited speaker – University of California, Davis West Coast Metabolomics Center Seminar: DDT to diabetes, adipose/cancer interactions, and insulin resistance: Broad applications of Targeted Mediator Analysis in Year 1 P&F Projects. January 2015.
3. Invited speaker – Loma Linda University Perinatal Biology Seminar: Metabolomic Applications in Health and Disease: Studies of Weight Gain/Loss, Insulin Resistance, and Premature Birth. August 2015.
4. Session leader – University of California, Davis West Coast Metabolomics Center International Summer Sessions in Metabolomics: WHNRC targeted analytics. August 2015.
5. Session Co-chair – Obesity and the Metabolic Syndrome symposium at the Experimental Biology Conference in Chicago, IL. as part of the American Society for Nutrition's (ASN) Energy and Macronutrient Metabolism research interest section (RIS). April 2017.
6. Invited speaker – Loma Linda University School of Public Health Seminar: Food and Function: Utilization of comprehensive profiling of food components and metabolite response to intervention and disease to gain health insight. June 2018.
7. Invited speaker – California Polytechnic State University, San Luis Obispo Research Lightning Talks: Metabolomics Targets for Plant, Animal, and Human Health Assessment. October 2018.
8. Invited speaker –Center for Health Research Happy Hour symposium. French Hospital Medical Center, San Luis Obispo, CA. First Trimester Metabolites Predict Gestational Diabetes Mellitus Diagnosis: Findings from the Healthy Beginnings Trial. May 2019
9. Invited speaker – California Polytechnic State University, San Luis Obispo Research Lightning Talks: Investigating Organisms and the Environment with Biochemical Analysis. October 2019.
10. Invited speaker – California Polytechnic State University, San Luis Obispo Research Lightning Talks: Investigating Organisms and the Environment with Biochemical Analysis. October 2020.
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Mentorship: Visiting scientists
December 2013 – May 2014: Jingjing Zhu – Visiting scholar, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences. Project: Methods for processing and analysis of lipid mediators in tissue.
January 2015 – June 2015: Kondwani Katundu – Visiting scholar, College of Medicine, Division of Physiology, Malawi. Project: Alterations in oxylipins in a large mammal model of insulin resistance.
High School students Jun 2012 – Aug 2012: Micah Tong – Young Scholars Program, UC Davis. Bullard High School.
Fresno, CA. Project: Evaluation of retinoid and carotenoid tissue extraction methods. Jun 2013 – Jun 2013: Reva Peer – Young Scholars Program, UC Davis. Oakmont High School.
Roseville, CA. Project: Evaluation of cyanide removal strategies in cassava. Jun 2013 – Aug 2013: Jade Tso – Project SEED, American Chemical Society. Franklin High
School. Elk Grove, CA. Project: Evaluation of methods for estimating beta-carotene concentrations in biofortified cassava.
Undergraduate students June 2010 – June 2011: Katherine Condreva – Nutrition Major, UC Davis. Project: Analysis of
biologically active retinoids in North American farm-raised freshwater fish. July – October 2011: Delphine La Porte – Nutrition Major. La Salle Beauvais University, France.
Project: Bioavailability and bioconversion of beta-carotene-biofortified cassava in American women.
May – September 2012: Chloe Dupertuis – Nutrition Major. La Salle Beauvais University, France. Project: Metabolism of the provitamin A carotenoid β-cryptoxanthin in the Mongolian gerbil: Absorption, tissue distribution, and dose-response assessment.
October 2015 – June 2016: Jennifer Coyle – Nutrition major. University College Dublin, Ireland. Project: Profiling postprandial plasma bile acid response to a challenge meal.
January 2017 – December 2017: Kelsey Degreef – Applied Nutrition major. California Polytechnic State University, San Luis Obispo. Project: Systematic review of metabolomics research related to gestational diabetes.
June 2017 – June 2018: Dana Bakke– Applied Nutrition major. California Polytechnic State University, San Luis Obispo. Project: Lipid signaling during fasting of Northern Elephant Seals, a mammal model of fasting-induced insulin resistance.
June 2017 – June 2018: Rodrigo Rosario– Applied Nutrition major. California Polytechnic State University, San Luis Obispo. Project: Lipid mediator response to vitamin A status in Philippine women.
November 2017 – June 2019: Sienna Biddle– Biology major. California Polytechnic State University, San Luis Obispo. Project: Impact of strawberry consumption on cardiometabolic indicators of health.
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January – June 2018: Lorenzo Rosales– Applied Nutrition major. California Polytechnic State University, San Luis Obispo. Project: Pre-analytical sample handling effects on metabolomics compound stability.
January – December 2018: Kalina Gardiner– Applied Nutrition major. California Polytechnic State University, San Luis Obispo. Project: Investigation of biomarkers for gestational diabetes prediction.
March 2018 – June 2018: Mia Abram– Applied Nutrition major. California Polytechnic State University, San Luis Obispo. Project: Strawberry consumption effects on the gut microbiome.
April 2018 – June 2019: Baylee Wilhelmson– Applied Nutrition major. California Polytechnic State University, San Luis Obispo. Project: Characterization of the Iberian Pig as an animal model of NAFLD.
April 2018 – December 2018: Rochelle Stewart– Applied Nutrition major. California Polytechnic State University, San Luis Obispo. Project: LC-MS metabolomics method development.
September 2018 – June 2019: Manuel Ramos– Applied Nutrition major. California Polytechnic State University, San Luis Obispo. Project: Metabolomics analysis for the assessment of NAFLD.
September 2018 – June 2018: Catherine Miyuki Johnson– Applied Nutrition major. California Polytechnic State University, San Luis Obispo. Project: Lipidomics analysis for the assessment of NAFLD.
Graduate students January 2019 – present: Rodrigo Rosario-Masters in Nutrition. California Polytechnic State University, San Luis Obispo. Project: Lifestyle intervention assessment for reduction of GDM recurrence. September 2019 – present: Catherine Johnson-Masters in Nutrition. California Polytechnic State University, San Luis Obispo. Project: Investigation of GDM biomarkers. September 2019 – present: Kayla Dillard-Masters in Nutrition. California Polytechnic State University, San Luis Obispo. Project: Effect of the consumption of different oils and sugars on NAFLD development.
Senior Theses: January – April 2017: Christina Marie Sharkey - Food Science and Nutrition Department.
Project: Utilization of omics analyses to investigate predictors of gestational diabetes mellitus.
April – June 2017: Andrew Kung – Food Science and Nutrition Department Project: Association between vitamin B12 deficiency and gestational diabetes mellitus: a review of literature
April – June 2017: Vivian Nguyen – Food Science and Nutrition Department Project: The effects of vitamin D on gestational diabetes mellitus
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September – December 2017: Rodrigo Rosario – Food Science and Nutrition Department Project: High vitamin A status is associated with elevated oxidative stress markers in lactating women
September – December 2017: Lorenzo Rosales – Food Science and Nutrition Department Project: Utilization of metabolomics to investigate biomarkers of autism
December – June 2018: Harlee Clarke – Food Science and Nutrition Department Project: Metabolic indicators associated with gestational diabetes and weight loss
December – June 2018: McKenna Wheeler – Food Science and Nutrition Department Project: Gestational diabetes and the difference between a high carbohydrate vs. a low carbohydrate diet
April – June 2018: Claire Mogelvang – Food Science and Nutrition Department Project: The effect of probiotic administration on patients with anxiety and/or depression: a review of the literature
April – June 2018: Sara Nygaard – Food Science and Nutrition Department Project: The effects of vitamin D supplementation on the prevention of preeclampsia in pregnant women: a review of clinical trials
September – December 2018: Rochelle Stewart – Food Science and Nutrition Department Project: The effect of vitamin A supplementation in premature newborns with pulmonary dysfunction
January – March 2019: Gabrielle Mohamed - Food Science and Nutrition Department. Project: Renoprotective Properties of Plant Based Protein on Chronic Kidney Disease Progression
January – March 2019: Manuel Ramos - Food Science and Nutrition Department. Project: The Effects of a High-Fructose, High-Coconut Oil Diet on Hepatic Damage and Development of Nonalcoholic Fatty Liver Disease in Iberian Pigs
January – March 2019: Baylee Wilhemson - Food Science and Nutrition Department. Project: The effects of a high-fructose and high-fat diet on lipoprotein metabolism and lipoprotein concentrations in iberian pigs.
January – March 2019: Catherine Johnson - Food Science and Nutrition Department. Project: Acylcarnitines and Nonalcoholic Fatty Liver Disease in Iberian Piglets.
April – June 2019: Kianne Aumiller – Food Science and Nutrition Department. Project: The effects of aerobic exercise on liver enzymes in patients with Nonalcoholic fatty liver disease
April – June 2019: Anna Lamb – Food Science and Nutrition Department. Project: First Trimester Metabolites Predict Gestational Diabetes Mellitus.
April – June 2019: Cooper Ray – Food Science and Nutrition Department. Project: First trimester metabolites predict gestational diabetes Mellitus
April – June 2019: Mikenna Corry – Food Science and Nutrition Department. Project: Glycine and Serotonin Levels Predict Gestational Diabetes Mellitus
Professional Affiliations: 2005 – 2014 Academy of Nutrition & Dietetics – Member 2011 - Present American Society of Nutrition – Member 2015 – Present Metabolomics Society - Member 2017 – Present Metabolomics Society of North America - Member
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Academic Affiliations: 2013 – 2016: UC Davis, Dept. of Nutrition 2016 – Present: California Polytechnic State University, San Luis Obispo
Awards: 2005 – 2007 Dean’s List, Loma Linda University, 6 quarters 2006 Kathleen Keen Zolber Scholarship Award, Loma Linda University 2006 Quindara Oliver Dodge Memorial Scholarship, American Dietetic Association
Foundation 2007 Rising Star Award, Loma Linda University 2007 Frances E. Fischer Memorial Scholarship, American Dietetic Association
Foundation 2007 IDDA Achievement Award, California Dietetic Association 2009 Henry A. Jastro Shields Research Award, UC Davis 2013 Carotenoids Gordon Research Seminar Travel Award 2015 American Society of Nutrition CARIG Travel Award 2017 Distinguished Alumnus Award, Loma Linda University References: John W. Newman, PhD Research Chemist, Obesity and Metabolism Research Unit U.S.D.A. Western Human Nutrition Research Center Associate Adjunct Professor, Dept. of Nutrition UC Davis Director, Central Services and Lipid Mediator Advanced Services, NIH-WCMC 430 West Health Sciences Dr., Davis, CA 95616 (530) 752-1009 [email protected]
Oliver Fiehn, PhD Director, West Coast Metabolomics Center Professor, Dept. of Molecular and Cellular Biology UC Davis Genome Center, room 1313 451 Health Sciences Dr., Davis, CA 95616 (530) 754-8258 [email protected] Suzanne Phelan, PhD Scientific Director, Center for Health Research Professor, Dept. of Kinesiology & Public Health California Polytechnic State University
1 Grand Avenue, San Luis Obispo, CA 93407 (805) 756-2087 [email protected] Betty J. Burri, PhD Retired Research Chemist, Immunity and Disease Prevention Research Unit U.S.D.A. Western Human Nutrition Research Center Retired Adjunct Professor, Dept. of Nutrition UC Davis 430 West Health Sciences Dr., Davis, CA 95616 (415) 860-0979 [email protected] Johannes Fahrmann, PhD Instructor, Clinical Cancer Prevention Red and Charline McCombs Institute for the Early Detection and Treatment of Cancer University of Texas, M.D. Anderson 1155 Pressler St., Houston, TX 77030 (713) 792-8239 [email protected] Publications:
1. La Frano M.R., Woodhouse L.R., Burnett D.J., Burri B.J. (2013). Biofortified cassava increases beta-carotene and vitamin A concentrations in the triacylglycerol-rich plasma layer of American women. Brit J Nutr. 110:310-320.
2. Katz J.M, La Frano M.R., Winter C.K., Burri B.J. (2013). Modeling potential beta-carotene intake and cyanide exposure from consumption of biofortified cassava. J Nutr Sci. 2:6, 1-8.
3. La Frano M.R., Zhu C., Burri B.J. (2014). Assessment of tissue distribution and concentration of beta-cryptoxanthin in response to varying amounts of dietary beta-cryptoxanthin in the Mongolian gerbil. Brit J Nutr. 11:968-978.
4. La Frano M.R., de Moura F.F., Boy E., Lonnerdal B., Burri B.J. (2014). Bioavailability of iron, zinc, and provitamin A carotenoids in biofortified staple crops. Nutr Rev. 72:289-307.
5. Engle-Stone R., Haskell M.J., La Frano M.R., Ndjebayi A.O., Nankap M., Brown K.H. (2014). Comparison of breast milk vitamin A concentration measured in fresh milk by a rapid field assay (the iCheckTM FLUORO) with standard measurement of stored milk by HPLC. Eur J Clin Nutr. 68:938-40.
6. La Frano M.R., Burri B.J. (2014). Analysis of retinol, 3,4-didehdroretinol, and 3-hydroxyretinol in fish liver, muscle, and feed of North American farm-raised freshwater fish. Aquac Nutr. 20:722-730.
7. La Merrill M., Karey E., Moshier E., Lindtner C., La Frano M.R., Newman J.W., Buettner C. (2014). Perinatal exposure to the pesticide DDT impairs energy expenditure and metabolism in adult female mice. PLoS One. 9:e103337.
8. Cediel G., Olivares M., Brito A., Lopez de Romana D., Cori H., La Frano M.R. (2015). Interpretations of serum retinol data from Latin America and the Caribbean: A systematic review. Food Nutr Bull. 36:S98-108.
9. Zhu C., Gertz E., La Frano M.R., Burnett D.J., Burri B.J. (2015). Effects of red palm oil-supplemented and biofortified gari on the carotenoid and retinyl palmitate concentrations of triacylglycerol-rich plasma of women. Nutr Res. 35:965-74.
10. Burri B.J., La Frano M.R., Zhu C. (2016). Beta-cryptoxanthin absorption, metabolism, and function. Nutr Rev. 74:69-82.
11. Green A.J., Graham J.L., Gonzalez E.A., La Frano M.R., He G., Petropoulou S.E., Park J., Denison M., Newman J.W., Havel P.J., La Merrill M.A. (2017). Perinatal triphenyl phosphate exposure accelerates Type 2 Diabetes onset and causes adipose accumulation in UCD-Type 2 Diabetes Mellitus Rats. J Reprod Toxicol. 68:119-29.
12. La Frano M.R., Fahrmann J., Grapov D., Fiehn O., Pedersen T.L., Newman J.W., Underwood M.A., Steinhorn R.H., Wedgwood S. (2017). Wedgwood S. Metabolic pertubations of postnatal growth restriction and hyperoxia-induced neonatal pulmonary hypertension in a rat model of bronchopulmonary dysplasia. Metabolomics. 13:32.
13. Olmstead K., La Frano M.R., Fahrmann J., Grapov D., Viscarra J.A., Newman J.W., Fiehn O., Crocker D.P., Filipp F.V., Ortiz R.M. (2017). Insulin induces a shift in lipid and primary carbon metabolites in a model of fasting-induced insulin resistance. Metabolomics. 13:60.
14. La Frano M.R., Thilsted S., Cai Y., Burri B.J. (2017). Vitamin A2 (3,4 –didehydroretinol) in small indigenous fish species as a source for addressing vitamin A deficiency. Int J Food Sci Nutr. 4:1-9.
15. La Frano M.R., Hernandez-Carretero A., Weber N., Borkowski K., Pedersen T.L., Osborn O., Newman J.W. (2017). Diet induced-obesity and weight loss alter bile acid concentrations and bile acid-sensitive gene expression in insulin target tissues of C57BL/6 J mice. Nutr Res. 46:11-21.
16. Tian J., Zhu J., Yi Y., Li C., Zhang Y., Zhao Y., Pan C., Xiang S., Li X., Li G., Newman J.W., Feng X., Liu J., Han J., Wang L., Gao Y, La Frano M.R., Liang A. (2017). Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation. Sci Rep. 7:8938.
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17. Hernandez-Carretero A., Weber N., La Frano M.R, Sears D.D., Newman J.W., Osborn O. (2018). Obesity induced changes in lipid mediators persist after weight loss. Int J Obes. 42:728-736.
18. La Frano M.R., Fahrmann J., Grapov D., Pedersen T.L., Newman J.W., Fiehn O., Underwood M.A., Mestan K., Steinhorn R.H., Wedgwood S. (2018) Umbilical cord blood metabolomics reveal distinct signatures of dyslipidemia prior to bronchopulmonary dysplasia and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 315: L870–L881.
19. La Frano M.R., Carmichael S., Ma C., Hardley M., Chen T., Rosales L., Borkowski K., Fiehn O., Shaw G.M., Stevenson D.K., Pedersen T.L., Newman J.W. (2018). Impact of clinical pre-analytical sample handling and biobank sample retrieval practices on the reliability of serum metabolomics analysis. Metabolomics 14:151.
20. Rood K., Lopez V., La Frano M.R., Fiehn O., Zhang L., Blood A.B., Wilson S. (2019). Gestational hypoxia and programming of lung metabolism. Frontiers Physiol. 10:1453.
21. Pascual R.W., Phelan S., La Frano M.R., Pilolla K.P., Griffiths Z., Foster G.D. (2019). Diet Quality and Micronutrient Intake among Long-term Weight Loss Maintainers. Nutrients. 11:3046.
22. Hernandez G., Smith V., Melnyk M., Burd M.A., Sprayberry K., Edwards M.S., Peterson D., Bennet D.C., Fanter R.K., Colombus D.A., Steibel, J.P., Glanz H, Immoos C., Rice M.S., Santiago-Rodriguez T.M., Blank J., VanderKelen J., Kitts C., Piccolo B.D., La Frano M.R., Burrin D., Maj M., Manjarin R. (2020). Dysregulation of FXR-FGF19 Signaling is Associated with Choline Deficiency, Dysbiosis and Colonic Hyperplasia and Inflammation in Juvenile Pigs with NASH. Am J Physiol Gastrointest Liver Physiol (In press).
23. Hagobian T.A., Brunner-Gaydos H., Schaffner A., Kitts C., Hubbard R., Malin S., La Frano M.R., Bennion K., Phelan S. Rationale and design of a randomized controlled trial examining oral administration of bisphenol A on hepatic glucose production and muscle insulin sensitivity in adults. Contemporary Clinical Trials Communications (In press).
Submitted Manuscripts:
1. Kukharenko A., Brito A., Moskaleva N., Markin P., La Frano M.R., Bochkareva N., Korobkova Y.N., Kozhevnikova M.V., Larcova E.V., Appolonova S.A. Plasma acylcarnitine profile determined by UPLC-MS/MS and its relation with cardiometabolic risk factors in adults. Submitted to Nutr Metab Cardiovasc Diseases.
2. Markin P.A., Brito A., Moskaleva N., La Frano M.R., Lartsova E.V., Yevgeny V.S., Lerner Y.V., Mikhajlov V.Y., Potoldykova N.V., Enikeev D.V., Appolonova S.A. Plasma metabolomic profile in prostatic intraepithelial neoplasia and prostate cancer and associations with the prostate-specific antigen and the Gleason score. Submitted to Metabolomics.
3. La Frano M.R., Brito A., Johnson C., Wilhelmson B., Gannon B., Fanter R., Pedersen T.L., Tanumihardjo S.A., Newman J.W. Hepatic metabolomic analysis of vitamin A deficiency in a Mongolian Gerbil model. Submitted to Mol Nutr Food Res.
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4. La Frano M.R., Amin S, Fanter R. Participation of undergraduate students in a controlled feeding study with metabolomics analysis to enhance learning of metabolism. Submitted to J Chem Educ.
Manuscripts in Preparation:
1. Muzhingi T., Zhu C., Degreef, K., Boy E., Lear M., Burri B.J., La Frano M.R. Effects of common African processing, cooking, and storage methods on β-carotene and cyanide retention in biofortified cassava (manihot esculenta). In preparation for PLoS One.
2. Tso J., La Frano M.R., Zhu C., Gertz E., Lear M., Burri B.J. Simple low cost methods compared to HPLC for estimating beta-carotene concentrations in biofortified cassava. In preparation for Food Chem.
3. Bakke D., La Frano M.R., Pilolla, K.P., Katundu K., Viscarra J.A., Crocker D.P., Ortiz R.M., Newman J.W. Lipid mediator response to fasting and insulin infusion in a large mammal model of fasting- induced insulin resistance. In preparation for Prostaglandins Other Lipid Mediat.
4. Hung S., Olmstead K., La Frano M.R., Newman J.W., Ojcius D. Filipp F.V. Oxylipin epoxide-mediated inflammatory response to Fusobacterium nucleatum infection in gingival epithelial cells. In preparation for Prostaglandins Other Lipid Mediat.
5. Vaziri A., Friebert A., Shipley W. , Kitagawa M. , Sanchez Porush S. , Dandekar E. , Paulson P. , Chen J., Maxwell R., La Frano M.R. Systematic Review of metabolomics studies investigating metabolic alterations associated with vitamin Status. In preparation for Frontiers in Nutr.
6. Degreef K., Sharkey C., Phelan S., La Frano M.R. Systematic Review of Metabolomics research on weight loss and gestational diabetes, both pre- and post-diagnosis, as well as long-term parent and child outcomes. In preparation for Diabetes.
7. Levine M.Z., So B., Mullin A.C., Watts K.R., Dillar K., La Frano M.R., Oza J.P. A novel 24-hour workflow from E. coli cells to cell-free protein synthesis. In preparation for Scientific Reports.
8. McMichael L., Johnson C., Fanter R., Alarcon N., Quintana-Diaz A., Jelalian E., Wing R., Phelan S., La Frano, M.R. Assessment of Biomarkers for Prediction of Gestational Diabetes Occurrence. In preparation for Metabolomics.
9. McNairn M., Heath H., Pantaleon M., Amin S., Pilolla K., Fanter R., La Frano, M.R. Investigation of a novel method of food intake biomarker assessment. In preparation for Frontiers Nutr.
10. Rosario R., Fanter R., Engle-Stone R., Haskell M.J., Agrawal K., Newman J.W., La Frano M.R. Metabolomics assessment of vitamin A status in Western Samar, Philippines. In preparation for Int J Vitam Nutr Res.
11. Zeltser N., Mayer I, Trahan M., Fanter R., Glanz H., Strand C., Burrin D., La Frano M.R., Manjarin R., Maj M. Diet-induced NASH is associated with neuronal loss, choline
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depletion and bile acid accumulation in frontal cortex of juvenile Iberian pigs. In preparation for FASEB
Other Publications:
1. La Frano M.R. Nov, (2012). Metabolism of Biologically Acitive Retinoids and Provitamin A carotenoids in Humans and Animal Models. University of California, Davis, 2012. 205p, PhD Thesis: #3555351.
2. Turner T., Burri B.J., La Frano M.R. (2012). Beta-cryptoxanthin: A vitamin A-forming carotenoid. In: Yamaguchi M., editor. Carotenoids: Properties, Effects, and Diseases (331–354). Hauppauge, NY: Nova Science Publishers, Inc.
Presentations/Abstracts:
1. La Frano M.R., Patil K. Neidlinger T.R., Burri B.J. Determining retinol and 3-hydroxy-retinol concentrations in fish liver and fish liver oils. California Dietetics Association Annual Meeting, April 2009, Riverside, CA.
2. La Frano M.R., Patil K. Neidlinger T.R., Burri B.J. Determining retinol and 3-hydroxy-retinol concentrations in fish liver and fish liver oils. Institute of Food Technologists (IFT) Conference, April 2009, Anaheim, CA.
3. La Frano M.R., Patil K., Neidlinger T.R., Burri B.J. Determining retinol and 3-hydroxy-retinol concentrations in fish liver and fish liver oils. Experimental Biology Conference, April 2010, Anaheim, CA.
4. La Frano M.R., Woodhouse L.R., LaPorte D., Burri B.J. Vitamin A equivalence of carotenoids from high-carotenoid cassava in healthy well-nourished women. Experimental Biology Conference, April 2012, San Diego, CA.
5. La Frano M.R., LaPorte D., Burri B.J. Bioavailable carotenoid and cyanogen content of biofortified cassava after food preparation. Experimental Biology Conference, April 2012, San Diego, CA.
6. La Frano M.R., Woodhouse L.R., Burnett D.J., Burri B.J. Biofortified cassava increases beta-carotene and vitamin A concentrations in the triacylglycerol-rich plasma layer of adults. University of California, Davis Graduate Group in Nutritional Biology Symposium, May 2012, Davis, CA.
7. La Frano M.R., Katz J.M., Woodhouse L.R., Burnett D.J., Winter C.K., Burri B.J. Biofortified cassava increases beta-carotene and vitamin A concentrations in the triacylglycerol-rich plasma layer of adults. Carotenoids Gordon Research Conference, Jan. 2013, Ventura, CA.
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8. La Frano M.R., Zhu C., Burri B.J. Impact of traditional processing methods on beta-carotene retention in biofortified cassava (Manihot esculenta), Experimental Biology Conference, April 2013, Boston, MA. Poster competition.
9. Burri B.J., La Frano M.R., Zhu C. Tissue concentrations of β-cryptoxanthin in Mongolian gerbils increase in parallel with its dietary concentration. American Chemical Society. Western Regional Meeting. Oct. 2013, San Francisco, CA.
10. La Frano M.R., Zhu C., Burri B.J. Effects of processing, cooking, and storage on β-carotene retention and bioaccessibility in biofortified cassava (Manihot esculenta). Experimental Biology Conference, April 2014, Boston, MA.
11. Burri B.J., La Frano M.R., Turner T., Qui X. Zhu C., Gertz E., Cai Y. Beta-cryptoxanthin absorption and metabolism. International Carotenoid Society Meeting, June 2014, Park City, UT.
12. Zhu C., La Frano, M.R., Cai Y., Burri B.J. Impact of traditional African processing and cooking methods on cyanide concentrations in biofortified cassava (Manihot esculenta). American Chemical Society Meeting, June 2014, San Francisco, CA.
13. Tso J., La Frano M.R., Zhu C., Gertz E., Burri B.J. Simple Low Cost Methods Compared to LC for Estimating Beta-carotene concentrations in biofortified cassava. American Chemical Society Meeting, June 2014, San Francisco, CA.
14. Burri B.J., Zhu C., Katz J., Tso J., La Frano M.R. Assessing the potential of biofortified cassava for improving indices of vitamin A status: Update on human studies. The Micronutrient Forum Global Conference – Bridging Discovery and Delivery, June 2014, Addis Ababa, Ethiopia.
15. La Frano M.R., Zhu C., Burri B.J. Effects of Processing, Cooking, and Storage on β-carotene Retention and Bioaccessibility in Biofortified Cassava (Manihot esculenta). The Micronutrient Forum Global Conference – Bridging Discovery and Delivery, June 2014, Addis Ababa, Ethiopia.
16. Hernandez-Carretero A., Weber N. Fahrmann J., La Frano M.R., Newman J. Fiehn O., Osborn O. Metabolomic and Transcriptomic changes associated with obesity and weight loss. California Diabetes Association Meeting. Feb. 2015. Los Angeles, CA.
17. La Frano M.R., Gannon B., Tanumihardjo S.A., Newman J.W. Targeted metabolomic profiling of lipid mediators influenced by vitamin A status in a rodent model. Experimental Biology Conference, April 2015, Boston, MA. Poster competition.
18. Hernandez-Carretero A., Weber N., Fahrmann J., La Frano M.R., Newman J.W., Fiehn O. Osborn O. Metabolite Changes Associated with Obesity and Weight Loss. LIPID MAPS Annual Meeting, May 2015, La Jolla, CA.
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19. Olmstead K., La Frano M.R., Fahrmann J., Grapov D., Gardner A., Kind T., Fiehn O., Newman J.W., Filipp F.V., Ortiz R.M. (2015) Metabolic shift in response to fasting and insulin infusion. International Conference of the Metabolomics Society. June 2015, San Francisco, CA.
20. Lengyel E., Mukherjee A., Fahrmann J., La Frano M.R., Grapov D., Fiehn O., Newman J.W. A systematic analysis of bidirectional metabolomics changes upon interaction of cancer cells with adipocytes. International Conference of the Metabolomics Society. June 2015, San Francisco, CA.
21. Wedgwood S., Fahrmann J., La Frano M.R., Newman J.W., Fiehn O., Mestan KK. Metabolomics of Neonatal Pulmonary Hypertension. International Conference of the Metabolomics Society. June 2015, San Francisco, CA.
22. Osborn O., Hernandez-Carretero A., Fahrmann J., La Frano M.R., Newman J.W., Fiehn O. Metabolite Changes Associated with Obesity and Weight Loss. International Conference of the Metabolomics Society, June 2015, San Francisco, CA.
23. La Frano M.R., Hernandez-Carretero A., Fahrmann J., Newman J.W., Fiehn O., Osborn O. Targeted metabolomic profiling of bile acids in metabolically active tissues reveals reversible and irreversible effects of obesity and weight loss. International Conference of the Metabolomics Society. June 2015, San Francisco, CA.
24. Rust B., La Frano M.R., Newman J.W., Agrawal K.A., Horn W., Welch L., Marco M., Martin R., Keim N.L. Bile Acid Responses in Methane and Non-Methane Producers to Standard Breakfast Meals. Experimental Biology Conference, April 2016, San Diego, CA.
25. La Frano M.R., Fahrmann J., Newman J.W., Fiehn O., Mestan KK., Wedgwood S. Metabolic Pertubations of Postnatal Growth Restriction and Hyperoxia-induced Neonatal Pulmonary Hypertension in a Rat Model of Bronchopulmonary Dysplasia. Lipid Mediators in Health and Disease Conference. May 2016, San Diego, CA.
26. La Frano M.R., Fahrmann J., Newman J.W., Fiehn O., Mestan KK., Wedgwood S. Metabolic Pertubations of Postnatal Growth Restriction and Hyperoxia-induced Neonatal Pulmonary Hypertension in a Rat Model of Bronchopulmonary Dysplasia. LIPID MAPS meeting. May 2016, San Diego, CA.
27. Elbadawi-Sidhu M., Ott S., La Frano, M.R., Newman J.W., Miller L. Hacszku A., Fiehn O., Zeki A. Metabolomic and Lipidomic Analyses Reveal that Inhalation of Statins Affects Pulmonary and Systemic Metabolism in the Rhesus Macaque Non-Human Primate Model. 7th Annual UC Davis Lung Research Symposium. June 2016, Davis, CA.
28. La Frano M.R., Fahrmann J., Grapov D., Newman J.W., Fiehn O., Mestan KK., Steinhorn R.H., Wedgwood S. Metabolic Pertubations of Postnatal Growth Restriction and
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Hyperoxia-induced Neonatal Pulmonary Hypertension in a Rat Model of Bronchopulmonary Dysplasia. 7th Annual UC Davis Lung Research Symposium. June 2016, Davis, CA.
29. Bakke D., Katundu K., Viscarra J.A., Crocker D.P., Ortiz R.M., Newman J.W., La Frano M.R. Lipid Mediator Response to Fasting and Insulin Infusion in a Large Mammal Model of Fasting- Induced Insulin Resistance. Cal Poly Summer Undergraduate Research Program Symposium. August 2017, San Luis Obispo, CA.
30. Rosario R., Engle-Stone R., Haskell M.J., Agrawal K., Newman J.W., La Frano M.R. Utilization of Targeted Metabolomics to Investigate the Impact of Vitamin A Supplementation of Women in Western Samar, Philippines. Cal Poly Summer Undergraduate Research Program Symposium. August 2017, San Luis Obispo, CA.
31. Bakke D., Pilolla, K.P., Katundu K., Viscarra J.A., Crocker D.P., Ortiz R.M., Newman J.W., La Frano M.R. Lipid Mediator Response to Fasting and Insulin Infusion in a Large Mammal Model of Fasting- Induced Insulin Resistance. CSU Student Research Competition. March 2018, San Luis Obispo, CA.
32. Bakke D., Katundu K., Viscarra J.A., Crocker D.P., Ortiz R.M., Newman J.W., Pilolla K.P., La Frano M.R. Lipid Mediator Response to Fasting and Insulin Infusion in a Large Mammal Model of Fasting- Induced Insulin Resistance. CAFES Spring Student Research Symposium 2018. May 2018.
33. Lopez V., La Frano M.R., Bosviel R., Newman J.W., Thorpe R., Fiehn O., Zhang L., Wilson S.M. High Altitude Hypoxia Impacts Omega-3 Fatty Acid Metabolites in Plasma of Fetal and Newborn Sheep. Experimental Biology Conference, April 2018, San Diego, CA.
34. Wilhelmson B., Gardiner K., Stewart R., Fanter R., Gannon B., Tanumihardjo S.A., Newman J.W., La Frano M.R. Metabolomics Investigation of Vitamin A Deficiency in a Rodent Model. Cal Poly Summer Undergraduate Research Program Symposium. August 2018, San Luis Obispo, CA.
35. Gardiner K., Stewart R., Wilhelmson B., Fanter R., La Frano M.R. Development of Mass Spectrometry-based Metabolomics and Aminomics Methods for Mammals and Yeast. Cal Poly Summer Undergraduate Research Program Symposium. August 2018, San Luis Obispo, CA.
36. Lopez V., La Frano, M.R., Bosviel R., Hillman T.C., Newman J.W., Thorpe R., Fiehn O., Zhang L., Wilson S.M. Long Term Hypoxia Reduces Levels of Oxylipins in Pulmonary
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Arteries and Venous Plasma of Fetal Sheep. Experimental Biology Conference. April 2019. Orlando, FL.
37. Kafeero I., Alvarez R., Lopez V., Bosviel R., La Frano, M.R., Newman J.W., Fiehn O., Zhang L., Wilson S. Long Term Hypoxia Reduces Antioxidant Levels and Causes a Glycolytic Shift in Neonatal Sheep Pulmonary arteries. Experimental Biology Conference. April 2019. Orlando, FL.
38. Johnson C., Wilhelmson B., Gannon B., Fanter R., Pedersen T.L., Tanumihardjo S., Newman J.W., La Frano, M.R. Metabolomics Investigation of Vitamin A Deficiency in a Rodent Model. CAFES Spring Student Research Symposium 2019. May 2019.
39. Lamb A., Ramos M., Ray C., Corry M., Fanter R., Alarcon N., Quintana-Diaz A., Phelan S., La Frano, M.R. First Trimester Metabolites Predict Gestational Diabetes Mellitus Diagnosis: A Case:Control Study. CAFES Spring Student Research Symposium 2019. May 2019.
40. Wilhelmson B., Gallo W., Hernandez G., Smith V., Rice P., Columbus D., Sprayberry K., VanderKelen J., Peterson D., Fanter R., Kitts C., Burrin D., Maj M., Manjarin R., La Frano M.R. Metabolomic characterization of a novel large animal model of non-alcoholic fatty liver disease. CAFES Spring Student Research Symposium 2019. May 2019.
41. Melynk M., Noland T., Smith V., Hernandez G., VanderKelen J., Kitts C., Glanz H., La Frano M.R., Manjarin R., Maj M. Western Diet-Induced Dysbiosis is Associated with Intestinal Hyperplasia in Juvenile Iberian Pigs. CSM Spring Student Research Conference 2019. May 2019.
42. Coffin M., Zeltser N., Nawar I., Hernandez G., Smith V., La Frano M.R., Manjarin R., Maj M. Assessment of Neurodegeneration in a Pig Model of Non-Alcoholic Fatty Liver Disease. CSM Spring Student Research Conference 2019. May 2019.
43. La Frano M.R., Amin S, Fanter R. Utilization of metabolomics to teach undergraduate students nutritional metabolism. Nutrition 2019 Conference, June 2019, Baltimore, MD.
44. Johnson C., Wilhelmson B., Gannon B., Fanter R., Pedersen T.L., Tanumihardjo S., Newman J.W., La Frano, M.R. Metabolomics Investigation of Vitamin A Deficiency in a Rodent Model. Nutrition 2019 Conference, June 2019, Baltimore, MD.
45. Ramos M., Lamb A., Fanter R., Alarcon N., Quintana-Diaz A., Phelan S., La Frano, M.R. First Trimester Metabolites Predict Gestational Diabetes Mellitus Diagnosis: A Case:Control Study. Nutrition 2019 Conference, June 2019, Baltimore, MD.
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46. Smith V., Hernandez G., Rice P., Columbus D., Sprayberry K., VanderKelen J., Peterson D., Fanter R., Kitts C., La Frano M., Burrin D., Maj M., Manjarin R. Western Diet-Induced Dysbiosis is Associated with Intestinal Hyperplasia and Dysregulation of FXR-FGF9 Gene Expression in Juvenile Iberian Pigs. Nutrition 2019 Conference, June 2019, Baltimore, MD.
47. Hernandez G., Smith V., Temple M., Columbus D., Sprayberry K., Peterson D., Fanter R., Kitts C., La Frano M.R., Burrin D., Manjarin R., Maj M.. A Diet-Induced Pediatric Model of Non-Alcoholic Fatty Liver Disease Using Neonatal Iberian pigs. Nutrition 2019 Conference, June 2019, Baltimore, MD.
48. La Frano M.R., Hernandez G., Smith V., Rice P., Columbus D., Sprayberry K., VanderKelen J., Peterson D., Fanter R., Kitts C., Burrin D., Maj M., Manjarin R. Metabolomic characterization of a novel large animal model of non-alcoholic fatty liver disease. Nutrition 2019 Conference, June 2019, Baltimore, MD.
49. Clifton S., Mace S., Zeltser N., Onat H., Trahan M., Nawar I., Mayer I, Hernandez G., Smith V., La Frano M.R., Manjarin R., Maj M. NAFLD is Associated with Memory Impairment and Changes in Metabolomic Profile in Brain Cortex of the Juvenile Iberian Pigs. Cal Poly Summer Undergraduate Research Program Symposium. August 2019, San Luis Obispo, CA.
50. McMichael L., McNairn M., Rosario R., Fanter R., Alarcon N., Quintana-Diaz A., Jelalian E., Wing R., Phelan S., La Frano, M.R. Assessment of Biomarkers for Prediction of Gestational Diabetes Occurrence. Cal Poly Summer Undergraduate Research Program Symposium. August 2019, San Luis Obispo, CA.
51. McNairn M., Pantaleon M., Amin S., Sagaral J., Le A., Pilolla K., Fanter R., La Frano, M.R. Investigation of Food Intake Biomarkers for Validating Dietary Questionnaires. Cal Poly Summer Undergraduate Research Program Symposium. August 2019, San Luis Obispo, CA.
52. McMichael L., Johnson C., Fanter R., Brito A., Alarcon N., Quintana-Diaz A., Schaffner A., Jelalian E., Wing R., Phelan S., La Frano, M.R. Identification of Potential Biomarkers for Early Prediction of Gestational Diabetes. Nutrition 2020 Conference, May 2020, Seattle, WA.
53. Dillard K., Coffin M., Hernandez G., Smith V., Johnson C., Immoos C., Blank J., Glanz H., Fanter R., Burrin D., La Frano M.R., Maj M., Manjarin R. Differential Effects of Fatty Acid Saturation and Chain Length on NASH in Juvenile Iberian Pigs. Nutrition 2020 Conference, May 2020, Seattle, WA.
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54. Johnson C., Harbottle B., Hernandez G., Smith V., Coffin M., Noland T., Dillard K., Glanz H., Fanter R., Burrin D., La Frano M.R., Maj M., Manjarin R. Comparison of High Fructose Corn Syrup versus Sucrose Consumption on Non-alcoholic Fatty Liver Disease in Juvenile Iberian Pigs. Nutrition 2020 Conference, May 2020, Seattle, WA.
55. Rosario R., Engle-Stone R., Haskell M.J., Brito A., Agrawal K., Fanter R., Newman J.W., La Frano M.R. Reduced Plasma Lipid Mediators are Directly Associated with Low Vitamin A Status in Women from Western Samar, Philippines. Nutrition 2020 Conference, May 2020, Seattle, WA.
56. McNairn M., Dillard K., Heath H., Pantaleon M., Fanter R., Brito A., Pilolla K., Amin S., La Frano, M.R. Investigation of an Alternative Collection Method for Food Intake Biomarkers Discriminates a High Fat-High Protein Meat-Based Diet from a High Carbohydrate Vegan Diet. Nutrition 2020 Conference, May 2020, Seattle, WA.
Patents (provisional)
Inhibition of prostaglandin D2 to prevent weight regain, submitted April 24, 207, EFS ID 2900060, Application Number 6248930
