MICRO- REACTIONTECHNOLOGYengineered by one-A

www.one-A.at

FIELDS OF APPLICATION - REFERENCES

Companies active in chemical research, development and production who want to move directly from research to production.

Companies active in the following sectors: - Pharmaceuticals

- Fine chemicals (e.g. crop protection, food & beverage, cosmetics)

- Specialty polymers (e.g. conductive, synthetic polymers, OLEDs)

- Fat chemicals

- And many more

THE ECONOMICALLYBETTER ALTERNATIVEYou think this one-A technology is expensive? You are mistaken.

It allows moving from research to production within the shortest

delays. The micro-structure reactor of one-A is equally suited for

R&D and production purposes, grows in line with your demands,

and thereby saves costs.

As required, the move from product and process development to

production is made either by “numbering up” or by “scale up”. By

selecting the optimal reactor and plant configuration on the basis

of the tests made, you will minimize error sources, reduce the risk,

and save time. These are but three reasons for the cost savings as

compared to conventional technologies.

Significantly less waste is generated during production thereby

increasing the production yield and enhancing product quality.

Discontinuous production in large batches is a thing of the past!

Demand-oriented production in these compact, space-efficient

micro-reactors allows optimizing and/or reducing stocks. At

the same time, the waste volume is reduced while the output is

increased and the quality is enhanced.

Fig. 5: Configuration of one, two and several micro-reactors

THE PATENTED one-A MICRO-REACTOR – ALL BENEFITS AT A GLANCE

Extremely fast mixing

Efficient heat transfer

Short and precisely adjustable retention times

High operational safety due to minimum hold-up

Safe control of hazardous reactions

Avoidance of by-products

Robust design for reactions generating high pressures

Low consumption of feed stock (up to -30%) and reduced waste

Excellent heat management

Homogeneous mixing of the reactants

Variable regarding capacity adjustment

Multiple reactions in one reactor feasible

Easy cleaning and product change-over within the shortest delays

Extreme longevity due to use of top quality materials

Combines tried and tested serial components with almost

unlimited flexibility

PLANT VALIDATIONUPON CUSTOMER REQUEST

Validation and qualification according to GMP and cGMP guidelines

Certification of small components according to GLP

Certification of overall plant units according to GAMP including CE marking

FDA compliance for use in pharmaceutical and food processes

Suited for use in explosion-hazardous areas due to high conductivity of the materials used

Dimensioning for use in high-pressure areas

Dimensioning for use in low-temperature and high-temperature areas

and many more

Fig. 4: Calculation models for designing the micro-reactor

Fig. 1: Fluid speeds and streamlines in the patented micro-reactor

THE NEWLY PATENTEDMICRO-REACTORBY one-A

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Are you working in the pharmaceuticals, fine chemicals or specialty polymer/engineering

polymer industry? Are you interested in curbing the reaction times of chemical synthesis

reactions also under high pressure and elevated temperatures?

The newly patented micro-reactor of one-A is an example for a micro-reaction technology that has

come of age. Every micro-reactor is adapted to the specific requirements of the respective reaction, can

be modularized and, as a consequence, works much more efficiently than other comparable reactors.

The technology developed by one-A allows for high throughput in a continuous operation mode. Micro-

reactors designed by one-A are in most cases not made from glass but from premium metals or alloys,

e.g. high-alloy stainless steels, Hastelloy alloys, tantalum or gold/platinum. This allows for faster heat

transfer and lower temperature gradients as compared to glass reactors. The targeted vortexing/whirling

and mixing is generated by a brand-new, patented reduction of the tube cross-section

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Henry-Reaction/ Nitro-Aldol

CondensationO2 Oxidation Ozonolysis Epoxidation

Suzuki-Miyaura-Coupling

AcidicEsterification Nitration

Micro-Reaction Technology

TOGETHER WE ARE STRONGIn the framework of the joint pro-

cess development any problems and

limitations that may exist are already

identified in advance and can thus be

solved. This iterative procedure guaran-

tees a successful implementation of your

process.

one-A, YOUR PARTNER FOR RESEARCH, DEVELOPMENTAND PRODUCTIONYou think that your requirements are so special, that this technology is not suited for you?

Upon request, one-A will supply single-source solutions developed in close cooperation with your team. The overall package

includes the following components: the micro-reactor, peripherals (piping, pumps), instrumentation as well as the control system,

automation and software. The reactor can be integrated into the process either by one-A or by yourself. If the reactor is intended

to operate as a stand-alone unit, one-A will be pleased to supply the corresponding single-source solution.

Fig. 2: Modular design with several heating and cooling zones for maximum flexibility

Fig. 3: Process development – micro-reaction technology

Basic dimensioningFeasibility check

Customer – one-A

Revision ofprocess parameters

Customer – one-A

Process verificationProcess optimization

Customer – one-A

Supply oftest reactor

one-A

INSTALLATION AND COMMISSIONING OF

PRODUCTION FACILITY

NO YES

Data collectionProcess coordination

Customer – one-A

Preparation ofproposal

one-A

Discussion ofproposal

Customer – one-A

Dimensioning ofproduction facility

Customer – one-A

Numbering upScale up

one-A

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one-A engineering Austria GmbH

Seestraße 11 | A-4844 Regau | AustriaT +43 (0)7672 - 24 522 - 0 | F +43 (0)7672 - 24 522 - 10 E: office@one-A.at | www.one-A.at