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7/28/2019 Microfludics-An Emerging Technology for SMEs
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Microfludics: An Emerging
Technology For SMEs
Dr Kevin Yallup
Technical Director
TFI Ltd
www.tfi-ltd.co.uk
http://www.tfi-ltd.co.uk/http://www.tfi-ltd.co.uk/http://www.tfi-ltd.co.uk/http://www.tfi-ltd.co.uk/7/28/2019 Microfludics-An Emerging Technology for SMEs
2/22
TFI
TFI (Technology For Industry) is a consultancy
focused on the commercialisation of EmergingTechnologies Help researchers to commercialise ideas
Help regional governments to stimulate technologytransfer activity
Help industrial companies understand and take upnew technologies
Microfluidics is one of most exciting emergingtechnologies
TFI has worked with developers and users ofmicrofluidics for more than 4 years
Currently working with UK Fluence application centrefor microfluidics
7/28/2019 Microfludics-An Emerging Technology for SMEs
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Agenda
What is microfluidics?
What can it do?
Who is using it? Where are the opportunities for SMEs?
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What is microfluidics?
the manipulation, processing and
measurement of fluids on a micro(100s m) scale. Laminar flow (no turbulence)
Can incorporate small particles
Leveraging modern manufacturingmethods to create microscopic channels, mixers,
reactors, analytical tools etc.
Integrate complete systems onto a singlechip
Will microfluidic chips have the impact
on fluidics of silicon chips on
electronics?
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Microfluidics compared to some
important objects
Nanofluidics Microfluidics
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Pump, valves,
manifold,
functionalchips, reagents
Nature Uses Microfluidics!
http://www.naspe-patients.org/patients/heart_disorders/images/normalheart1.jpghttp://www.naspe-patients.org/patients/heart_disorders/images/normalheart1.jpghttp://www.naspe-patients.org/patients/heart_disorders/images/normalheart1.jpghttp://www.naspe-patients.org/patients/heart_disorders/images/normalheart1.jpghttp://www.naspe-patients.org/patients/heart_disorders/images/normalheart1.jpghttp://www.people.virginia.edu/~rjh9u/gif/circsys.gifhttp://www.naspe-patients.org/patients/heart_disorders/images/normalheart1.jpg7/28/2019 Microfludics-An Emerging Technology for SMEs
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What can microfluidics do?
Laminar flow, diffusion controlled regime
Mixing of fluids Highly controlled reactions
Transport of fluids Channels
Pumping and valves
Precise temperature control
Micro dispensing
In channel electrodes Sensors, heaters
Optical waveguides and ports
But Microfluidics is bad at Separation
Filtration, sorting solid phase
Batch processing
SOLIDS
Diffusion Mixing
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Why use microfluidics?
Miniaturisation
Integration of systems on a single chip
Low cost, disposable devices
Micro dispensing
Better control of physical parametersof flow
Smaller volumes being processed
Scale up can avoid changes in
process conditions
Labonachip
Manufacturin
g
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Lab-on-a-Chip
?
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Lab on a Chip
Microfluidic Chip Instrument
+
Courtesy of Syrris Ltd
Fluid processing
Electrodes
Waveguides for optical sensors
Functional surfaces
Pumps, fluid reservoirs, sample inlet
Electronic instruments
Lasers
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Applications of Microfluidics
Medical diagnostics
Genomics and Proteomics
Cell Processing
Pharmaceuticals
Ink jet printing Chemicals
Fuel Cells
ICT
New applications emerging all the time
L
abonachip
Manufacturing
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Some Examples of Lab on a Chip
Products
Fluidigm proteincrystallisation
Istat blood
analyser
Pelikan blood
glucose
Syrris Africa system
Sophion Cell Patch Clamp
http://www.thinxxs.de/references/files/pel.htm7/28/2019 Microfludics-An Emerging Technology for SMEs
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Some Examples of Microfludic
Systems for Manufacturing
CYTOSPilot
Nitroglycerine plant
Developed: IMM, Germany
Operated: Xian Chemical
Industrial Group (HAC)
Inkjet
printheads:
HP, Epson,
Cannon,
Lexmark
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Case Study: Fluence Application
Centre
UK Fluence Application Centre for polymer
microfluidics
Other materials also possibe (glass, metal, silicon
etc.) through UK and European network of partners
Funded by UK Technology Strategy Board
Managed by Epigem Ltd, Redcar, UK
Objective:
A service within the UK MNT Network focused on
supporting the development of products enabled by
integrated microfluidic devices and hybrid polymer
solutions
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Making a lab on a Chip Device
FluidPorts
Laminate
on Lid
channels,nozzles,
wells,
membranes,
arrays
TopSpot HSG-IMIT,
Germany
Introduction
http://localhost/var/www/apps/tom/Local%20Settings/Temporary%20Internet%20Files/OLKBB/Epigem%20Company%20Overview.PPT7/28/2019 Microfludics-An Emerging Technology for SMEs
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3D Integrated Microfluidics Optical Waveguides
Micro / Nano Structured Surfaces Fine Line Microcircuitry - electrodes
Mounting holes
Fluid flow path
Ferrule
2 chips
bonded
together
Additional
chip
assembled
via
ferrules
Parallel flow paths
Underlayer
0-1.5m
Feature Width >200nm Feature Height50nm to 2mm
Substrate:
Rigid or flexible
Overlayer
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Fluence: evolving development
infrastructure
Access to IP portfolio and skilled personnel
Technologies Coating, UV embossing / imprinting /
micromoulding
Printing Lithography, screen, ink jet, gravure,bead, slot etc
Electroplating
Laminating, bonding
Batch (sheet or board) or reel to reel on film
Clean room facilities, design, fabrication andapplication testing capabilities Shaping
Electrode and optoelectronics integration Surface coating
Macro to micro world interconnection, sealing andbonding
Batch and roll-roll processing capability
http://localhost/var/www/apps/tom/Local%20Settings/Temporary%20Internet%20Files/OLKBB/Epigem%20Company%20Overview.PPT7/28/2019 Microfludics-An Emerging Technology for SMEs
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Support for Product Development
TOOLKIT CONCEPT TESTING
DEVICES
MANUFACTURED
COMPONENTS
Idea andcore producttechnology
(From customer)
Proof ofConceptservice
Pre-productio
nprototype(Functional
versionof evolvingproduct)
Productionprototype
(Provesmanufacturabili
ty and widerintegration)
Productfor launch(Manufacture)
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Example customer specification for
microfluidic function integration
Functions integrated to meet OEM customer
needs
Heating
Valve control
Hybrid bonding - quartz to polymer
Electrical interconnection for sensor readout
Microfluidic circuit for fluid distribution
Plug and play demountable leak free fluid
interconnect to disposable sensor
Macro to micro world interconnection hierarchy
integrating milli and microfluidics
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Opportunities for SMEs in
Microfluidics
Manufacturing
equipment (device
sheet, roll-roll)
Materials
Device
Manufacturing
Functional
Coatings
Sensors
and
Detectors
Instrument
-ation andelectronics
Product and
systemdevelopment
End
Users
Research and Development
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Summary
Microfluidics is a technology that is rapidly
expanding into a wide range of applications ICT
Laboratory instrumentation
Medical and healthcare
Chemical manufacturing
Wide range of manufacturing technologies,leading edge technology not needed
Product design is still a challenge
There are a lot of opportunities throughoutthe supply chain for SMEs
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Applications of Nanotechnology and Advanced
Materials for SMEs14:30-15:45 C / E (P) Dr. Kevin Yallup -Technical Director, Technology For IndustryLtd, UK Charlie T. Chow - Managing Director, Nano-fabric Co., Ltd Dr. Jiyun FENG - Technical Project Manager,Nano and Advanced Materials Institute Limited Dr. Krassimir Velikov - Unilever Food &Health Research Institute