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1 TJ Robertson Chief Operating Officer TIME MEDICAL Systems September 15, 2010
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TJ RobertsonChief Operating OfficerTIME MEDICAL Systems
September 15, 2010
TIME MEDICALSYSTEMS
A brief introductionA brief introduction
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TIME MEDICALSYSTEMS
Professor Q.Y. Ma, PhDProfessor Q.Y. Ma, PhD
Founder,Founder,Chairman & CEOChairman & CEO
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Professor Q.Y. Ma, PhDProfessor Q.Y. Ma, PhD
Founder,Founder,Chairman & CEOChairman & CEO
Founded on core technologyFounded on core technologydeveloped in the USA atdeveloped in the USA atColumbia University’sColumbia University’s
Translational Research Lab.Translational Research Lab.and later validated & refinedand later validated & refinedat Harvard Medical Schoolat Harvard Medical Schooland Hong Kong Universityand Hong Kong University
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OurOur USAUSA--basedbased Team of Clinical AdvisorsTeam of Clinical Advisors
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Professor William Bradley, M.D., PhDChairman of RadiologyUCSD Medical CenterUniversity of California, San Diego
Prof. Bradley has authored more than 160articles and 17 books on Radiology & MRI.
He is one of the world’s foremostauthorities in MRI & Radiology - and hasprovided 3 decades of critical leadershipacross clinical, technical, research andpolicy-making initiatives.
Professor Ferenc Jolesz, M.D.Director of the MRI DivisionBrigham & Women’s HospitalHarvard Medical School
Prof. Jolesz has published over 300articles and book chapters on Surgery,Computer Science, Neurology,Neurosurgery, Radiology and MRI.
He is widely recognized for his pioneeringinnovations in Radiology and MRIResearch.
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Our ChinaOur China--based Partnersbased Partners
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Taizhou, Jiangsu May 31, 2010
TIME MEDICAL SYSTEMSproudly hosts Mr. Li Yuan Chao,
Chairman of theOrganization Department of the
Chinese Communist Party& former Secretary General of Jiangsuprovince. He is a strong supporter of
China Medical City
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Our FacilitiesOur Facilities
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R&D FacilityR&D Facility
HongHong KongKong
HK ScienceHK Science ParkPark
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R&D FacilityR&D Facility
HongHong KongKong
HK ScienceHK Science ParkPark
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R&D FacilityR&D Facility
SingaporeSingapore
Int’l Business ParkInt’l Business Park
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R&D FacilityR&D Facility
SingaporeSingapore
Int’l Business ParkInt’l Business Park
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R&D FacilityR&D Facility
ShanghaiShanghai
ZhangjiangZhangjiangHiHi--tech Parktech Park
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R&D FacilityR&D Facility
ShanghaiShanghai
ZhangjiangZhangjiangHiHi--tech Parktech Park
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R&D FacilityR&D Facility
San DiegoSan Diego
UCSD Medical CenterUCSD Medical Center
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R&D FacilityR&D Facility
San DiegoSan Diego
UCSD Medical CenterUCSD Medical Center
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Production FacilityProduction Facility
TaizhouTaizhou
China Medical CityChina Medical City
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Production FacilityProduction Facility
TaizhouTaizhou
China Medical CityChina Medical City
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A brief historyA brief history
MRI Innovations
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MRI Innovations
Higher B0 = higher SNR
The trend of using higherfield strengths to improveSNR is coming to an end,driven mainly by the need forcost-containment andregulatory constraintsplaced on clinical MRI < 4T.
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Magnetic Fields (B0)
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Higher B0 = higher SNR
The trend of using higherfield strengths to improveSNR is coming to an end,driven mainly by the need forcost-containment andregulatory constraintsplaced on clinical MRI < 4T.
In spite of RF Array Coil improvements,copper RF coils are the dominant sourceof noise in the MR image.
HTS materials are now considered thebest solution for improving SNR.
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Radio Frequency (RF) Coils
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In spite of RF Array Coil improvements,copper RF coils are the dominant sourceof noise in the MR image.
HTS materials are now considered thebest solution for improving SNR.
Phantom image comparison:
(a) signal intensity plot and(b) corresponding cropped images
Room temperature copper
Cooled copper
HTS coil
TIME MEDICAL SYSTEMSbrings HTS RF Technology
to the MRI market.
On June 1, 2010 Professor Ma andhis team received Patent approval
for the development of the 1st“INTEGRATED SUPERCONDUCTOR
MR IMAGING SYSTEM”
According to Prof. Ma“This marks the beginning of the
SUPER MRI era!”
TIME MEDICALSYSTEMS High Temperature
Superconductors (HTS)
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TIME MEDICAL SYSTEMSbrings HTS RF Technology
to the MRI market.
On June 1, 2010 Professor Ma andhis team received Patent approval
for the development of the 1st“INTEGRATED SUPERCONDUCTOR
MR IMAGING SYSTEM”
According to Prof. Ma“This marks the beginning of the
SUPER MRI era!”
TIME MEDICAL SYSTEMSbrings HTS RF Technology
to the MRI market.
On June 1, 2010 Professor Ma andhis team received Patent approval
for the development of the 1st“INTEGRATED SUPERCONDUCTOR
MR IMAGING SYSTEM”
According to Prof. Ma“This marks the beginning of the
SUPER MRI era!”
TIME MEDICALSYSTEMS
High TemperatureSuperconductors (HTS)
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TIME MEDICAL SYSTEMSbrings HTS RF Technology
to the MRI market.
On June 1, 2010 Professor Ma andhis team received Patent approval
for the development of the 1st“INTEGRATED SUPERCONDUCTOR
MR IMAGING SYSTEM”
According to Prof. Ma“This marks the beginning of the
SUPER MRI era!”
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The beginning of a new era:The beginning of a new era:
HTS MRI
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HTS MRI
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Hybridthe HTS System
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Hybrid MONA
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Hybrid MONAthe HTS System
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The HTS breakthroughled to the new era of
low-cost, high-performanceMRI scanners.
Hybrid PICA (whole body) and Hybrid MONA(dedicated orthopedic) MRI scanners are the
first MRI scanners to take advantage ofHTS RF Coil Technology.
Operating in conventional or HTS mode,the Hybrid PICA and Hybrid MONA MRI scanners
enable a full range of clinical applications,with competitive IQ and scan time.
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The HTS breakthroughled to the new era of
low-cost, high-performanceMRI scanners.
Hybrid PICA (whole body) and Hybrid MONA(dedicated orthopedic) MRI scanners are the
first MRI scanners to take advantage ofHTS RF Coil Technology.
Operating in conventional or HTS mode,the Hybrid PICA and Hybrid MONA MRI scanners
enable a full range of clinical applications,with competitive IQ and scan time.
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The news of HTS is getting out.And the recognition is coming in.
On June 24, 2010 Professor Ma and histeam accepted the award for
2010 Medical Imaging ProductInnovation of the Year!
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The news of HTS is getting out.And the recognition is coming in.
On June 24, 2010 Professor Ma and histeam accepted the award for
2010 Medical Imaging ProductInnovation of the Year!
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A brief summaryA brief summary
MRI Markets,Opportunities
& Trends
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MRI Markets,Opportunities
& Trends
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2,000 MRI systems sold annually / USD $5 Billion annual market
16% annual growth rate
22,000 MRI systems installed globally
30 MRI units per 1M population (USA/Japan)
1.5 MRI units per 1M population (China)
< 1 MRI unit per 1M population (Developing markets)
Approximate Customer Realized Price in Developed Markets (in USD) $3M - Ultra High-field (3T) $1.5M - High-field (1.5T) $500K - Low-field (0.35T)
Global MRI Market and TM opportunityGlobal MRI Market and TM opportunity
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GlobalMRI forecast in Mio. USD
2,000 MRI systems sold annually / USD $5 Billion annual market
16% annual growth rate
22,000 MRI systems installed globally
30 MRI units per 1M population (USA/Japan)
1.5 MRI units per 1M population (China)
< 1 MRI unit per 1M population (Developing markets)
Approximate Customer Realized Price in Developed Markets (in USD) $3M - Ultra High-field (3T) $1.5M - High-field (1.5T) $500K - Low-field (0.35T)
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Value!
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Value!
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Performance!
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Performance!
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Innovation!
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Innovation!
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Lowest cost of ownershipLowest cost of ownership
Value
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Value
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Fixed costs
Equipment Lease
$ / month
Service Contract
$ / month
Revenue per patient
$ / patient
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Lowest break-even fixed costs in the MR industry!Based on xyz market figures
Breakeven
< x Patient per day
(y days / week)
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Fixed costs
Equipment Lease
USD $8,800 / month
Service Contract
USD $4,100 / month
Revenue per patient
USD $360
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Lowest break-even fixed costs in the MR industry!Based on Hong Kong market figures
Breakeven
< 2 Patient per day
(6 days / week)
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Hardware, Software & Clinical ApplicationsHardware, Software & Clinical Applications
Performance
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Performance
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MONA / PICA Specs: Brains and Muscle
• 0.2T / 0.35T• Vertical Field, Open• 30 cm / 42cm opening• 5,500 kg / 17,000 kg• Auto Shimming
Magnet• SE, GE, FSE, FLAIR, STIR, IR-FSE,
Single Shot , 2D/3D TOF MRA• Single, multi-slice, radial, 3D volume
PulseSequences
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• 25 mT/m / 33 mT/m (Amplitude)• 50 T/m/s / 90T/m/s (Slew Rate)• 0.5 ms / 0.37 ms (Rise Time)
Gradients
• CP: Head, C-Spine, Shoulder, Knee,Extremity, Wrist/Hand, Foot /Ankle –For both MONA & PICA
• CP: Breast, Flex Body (3 sizes) – ForPICA only
• Multi-Array L/S Spine
RF Coils
• FOV: 5cm – 42 cm• TR: 6 ms – 18 sec• TE: 4 ms (minimum)• Slice Thickness: 2D 2mm (min)• Slice Thickness: 3D 0.25m (min)
ImagingParameters
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Easy-to-Operate Graphic User Interface
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Efficient Siting
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Site Planning Support
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A brief look at the proofA brief look at the proof
MRI Images
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MRI Images
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HTS Head Coil
HTS Helmholtz Coil HTS Wrist Coil
Quad C-Spine Array CoilQuad Head Array Coil
Quad Body Array Coil
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HTS Knee Coil
Quad Wrist Array Coil
Quad Ankle Array CoilQuad Knee Array Coil
Quad Shoulder Array Coil
Large FOV Spine Coil
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Patient Comfort + Fast Scan Times =Patient Comfort + Fast Scan Times =
MRI for All…
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MRI for All…
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Hybrid MONA and PICA’s Open-design offerspatient comfort and fast acquisition times.
This ensures that scans are successfullycompleted on the most challenging patients.
Especially important for children, elderly &sedated patients, as well as those sufferingfrom claustrophobia.
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Hybrid MONA and PICA’s Open-design offerspatient comfort and fast acquisition times.
This ensures that scans are successfullycompleted on the most challenging patients.
Especially important for children, elderly &sedated patients, as well as those sufferingfrom claustrophobia.
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Patient Comfort
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Fast Acquisition TimesThe 20 minute BRAIN MRI Scan
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NonNon--obsolescence through HTSobsolescence through HTS
Innovation
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Innovation
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Copper RF coilsremain the dominant source of noise
in MR image.
HTS RF Coilsovercome this problem!
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Copper RF coilsremain the dominant source of noise
in MR image.
HTS RF Coilsovercome this problem!
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Phantom image comparison:
(a) signal intensity plot and(b) corresponding cropped images
Room temperature copper
Cooled copper
HTS coil
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A brief comparisonA brief comparison
HTS Results
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HTS Results
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HTS vs. CopperHTS Coil Technology
0.35T
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Copper Coil
SNR = 57
HTS Coil
SNR = 192
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HTS Coil TechnologyHTS vs. Copper
0.2T
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Copper Coil
SNR = 25
HTS Coil
SNR = 51
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HTS vs. Cu RF Coil at 2THTS Coil Technology
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HTS coil Cu surface coil Cu volume coil
2T Rat Brain in-vivo images using HTS surface coil.
The SNR ratio for is 8:4:1 respectively
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1. LN / out Tubes
2. Vacuum Port
High Resolution InHigh Resolution In--Vivo MR MicroscopyVivo MR Microscopy
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3. DC connector
4. Seal Screws
Rat brain images obtained in vivo with an HTS coil at 2.0T
25 µm resolution
Images courtesy of the NIH Center for In vivo Microscopy at Duke University
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HTS White Paper
The Hybrid MRI systemscan be run
in the traditional,or HTS mode…
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The Hybrid MRI systemscan be run
in the traditional,or HTS mode…
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HTS Poster fromISMRM 2010
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HTS Poster fromISMRM 2010
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HTS:Peer Review
Journal Articles
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HTS:Peer Review
Journal Articles
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Hybrid MONA & Hybrid PICAbring a new dimension to MR Imaging.
HTS Technologymake high performance MRI available to all.
TIME MEDICAL SYSTEMSVision Beyond Imagination.
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863 mm slice thickness
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873 mm slice thickness
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Thank You.
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Thank You.
This information is furnished without warranty, representation, or license of any kind, except that it is accurate to the best of Time Medical’s knowledge or obtained from sources believed to be accurate. TimeMedical does not assume any legal responsibility for use or reliance upon same. Customers are encouraged to conduct their own evaluation. Before using any product, read the product manuals and labels. Forproducts/features under development the information is provided to assist you. Until Time Medical releases this product for general sale, Time Medical reserves the right to alter prices, specifications, features,capabilities, function, manufacturing release dates, and even general availability of the product at any time.
