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JACS ISTHE PLACEFOR BIORESEARCH
JACSEditors are renownedresearchers, like ProfessorAlannaSchepartz
The world’s preeminent journal for all of chemistryand the interfacing areas of science bit.ly/JACSBio
JACSAssociateEditorAlannaSchepartz
MiltonHarris ‘29Ph.D. ProfessorofChemistry
ProfessorofMolecular, Cellular,
andDevelopmentalBiology
Director,YaleChemicalBiology Institute
YaleUniversity
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Mandarin Ducks (Aix galericulata) are frequently featured
in Chinese art and are regarded as a symbol of fidelity.
Fidelity atits finest.Q5™ High-Fidelity
DNA PolymeraseQ5 High-Fidelity DNA Polymerase sets a new
standard for both fidelity and performance. With
the highest fidelity amplification available (>100X
higher than Taq), Q5 DNA Polymerase results
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Polymerase represents the finest in fidelity.
For more information, visit
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Robust amplification even with high GC amplicons
Amplification of two human genomic amplicons of mid to high GC content.All reactions were conducted using 30 cycles of amplification and visualizedby microfluidic LabChip® analysis. All polymerases were cycled according tomanufacturer’s recommendations. For the 78% GC amplicon, GC Buffers orenhancers were used when supplied with the polymerase.
A = Q5™ High-Fidelity DNA Polymerase (NEB)B = Phusion® High-Fidelity DNA Polymerase (NEB)C = KOD DNA Polymerase (EMD)D = PfuUltra™ High-Fidelity DNA Polymerase (Agilent)
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ALSO AVAILABLE: Optimized NEBNext® formulation
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© 2012 Roche Diagnostics.All rights reserved.
Reveal Your qPCR Super Powers!
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Read abstracts, career advice,
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A new way tolook at science
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ARTICLE: QuantumSimulation of FrustratedClassical Magnetism inTriangular Optical Lattices
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ARTICLE: Consciousness:What, How andWhy
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Brought to you by theScience/AAAS Custom
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Webinar sponsored by
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WEBINAR
Participants
Rafael Irizarry, Ph.D.
Johns Hopkins BloombergSchool of Public HealthBaltimore, MD
Don A. Baldwin, Ph.D.
Pathonomics LLCPhiladelphia, PA
Researchers need to be aware of the pitfalls that can lurk in data-intensive studies and that errors or misinterpretations in
data analysis can lead them to overestimate their �ndings. Today the research community has a variety of high throughput
methods available and the results of one method can be readily validated using a different, orthogonal technology, such as
the use of real-time PCR experiments to validate microarray results. With the emergence of sequencing-based studies that
require scientists to identify rare genetic phenomena using relatively new methods, it is increasingly important to complement
these studies with an orthogonal technology such as microarrays.
During the webinar, the panelists will:
� Discuss the importance and relevance of validating data using
orthogonal methods
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results using microarray technology
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Wednesday, December 5, 2012
12 noon ET, 9 a.m. PT, 5 p.m. UK, 6 p.m. CET
Validating ComplexBiologyHow Arrays Can Complement
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981www.sciencemag.org/products SCIENCE VOL 338 16 NOVEMBER 2012
Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are
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Electronically submit your new product description or product literature information! Go to www.sciencemag.org/products/newproducts.dtl for more information.
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OLIGONUCLEOTIDE PROBES
XGen Lockdown Probes are individually synthesized 60ñ120 nu-
cleotide 5í-biotinylated capture oligonucleotides designed to enable
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gions of the genome. xGen Lockdown Probes are ideal for target
enrichment and custom panel development, and capture sets can
be easily expanded. Available at three different scales (mini ñ 2
pmole, standard ñ 20 pmole, and XL ñ 200 pmole), users can design
their initial capture panels using the mini scale and extend them by
progressively supplementing with more probes. Whether used with
custom capture panels, or for supplementing existing panels, xGen
Lockdown Probes provide approximately 5,000-fold enrichment with
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more, the probes can be added to array-derived RNA baits to en-
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Integrated DNA Technologies
For info: 800-328-2661 www.idtdna.com
AUTOMATED CELL COUNTER
The TC20 automated cell counter is the next generation of the TC10
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of live mammalian cells in 30 seconds. The TC20 systemís improved
lens and cell counting algorithm make it compatible with a broader
range of cell sizes and types. This includes cells smaller than 10 �m
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producible cell counts with reduced user-to-user variability, remain
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Bio-Rad
For info: 800-424-6723 www.bio-rad.com
CELL ADHESION ASSAYS
A new suite of cell adhesion assays have been designed to evaluate
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SPE SAMPLE PREPARATION SYSTEM The Microlute solid-phase extraction (SPE) sample preparation sys-
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Porvair Sciences
For info: +44-(0)-1372-824290 www.porvair-sciences.com
MULTI-ION-BEAM TOOL The ORION NanoFab is the � rst multi-ion-beam tool based on Gas Field Ion Source (GFIS) technology. As a major enhancement to the existing helium ion microscope, ORION NanoFab also
utilizes neon ions. The system is therefore capable of providing a complete sub-10 nanometer
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This makes ORION NanoFab the most versatile nanofabrication and imaging platform available.
Carl Zeiss
For info: +49-73-64202-294 www.zeiss.de
Announcing our new partnership with NASA Federal Credit Union
Dear Member:
AAAS is committed to ofering you member benefts that ft your needs and make your membership
more valuable.
With that in mind AAAS is embarking on a new partnership with NASA Federal Credit Union that will
provide you with access to a wide range of fnancial tools and products. Like AAAS, NASA Federal Credit
Union is dedicated to serving the scientifc community. This shared perspective is just one of the many
reasons that we are embarking on this partnership.
As you may know, we have recently ended our banking relationship with Bank of America, but we’re
confdent that our new partnership with NASA FCU will provide you with a superior banking experience.
NASA FCU ofers members better ways to save and smarter ways to borrow with friendly, professional
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Moreover, unlike other fnancial institutions that have public stockholders, NASA FCU is a not-for-proft
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you will enjoy unique benefts like: better loan rates, higher dividends and state-of-the-art products and
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We’ll be sending you more information about this great new beneft over the coming months. In the
meantime, be sure to visit nasafcu.com/AAASpackage to apply for the new AAAS Platinum Advantage
Rewards or Platinum Cash Rewards credit cards. You can also take a sneak peek at the AAAS Check Card
and Checks coming soon.
Sincerely,
Ian King
Director of Marketing and Membership, AAAS
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