Cardiology
Testing
Sandra Keavey, DHSc,
DFAAPA, PAC
Before We Start CPR
Let’s go a few weeks back in time….
Call
911
History
Let’s get the history.
HistoryTell me about
your chest pain.
HistoryAn elephant is
standing on my chest.
HistoryAn elephant is
standing on my chest.
I feel tired and
short of breath.
HistoryAn elephant is
standing on my chest.
I feel tired and
short of breath.
The pain is going
down my arm.
The Story
Chest pain
Don’t expect the Hollywood Heart Attack.
Therefore eliciting the history is YOUR responsibility.
Patients may downplay their symptoms but they were
worried enough to be seen.
Ask about…….
What does it feel like? Had similar pain before?
Where is the pain? If recurrent, same location?
When did it start? Intermittent?
How does it get better or worse? Rest vs activity?
Associated symptoms- weakness, nausea,
diaphoresis, dyspnea, lightheadedness.
Pain….. please Sharp
Dull
Squeezing
Crushing
Pressure
Sore
Irritation
Tingle
Cramp
Ache
“Discomfort”
Different
More Pain..
In describing pain ask about
heaviness, pressure, squeezing,
aching
Discomfort in the chest, back,
neck, shoulders, or arms, wrists,
elbows, between the shoulder
blades
Aching in the jaw, throat, or even
gums or earlobes
Fatigue, shortness of breath, loss of
drive or lack of energy
Pretty good story…even with no cardiac
history or co-morbid conditions.
When you hear chest pain it is angina or a heart attack until you convince yourself it’s not.
History is paramount in creating a list of differential diagnoses that will guide testing and management.
It will allow you to have information to convince a patient to have testing they may not want or that testing they do want is not indicated.
Be sure you document the interview.
What Constitutes a “Good Story”?
When did it start? Minutes or hours
What were you doing? Activity
What happened when you sat down or stopped? Stopped, eased up
Where is the pain? Precordium
Where does it go? Shoulders, neck, back
What symptoms are associated with it? Nausea, weakness, diaphoresis, dyspnea, “not right”
Is this pain similar to what you have had before? Yes
History of CAD, Angina, DM? Yes
A“Bad Story”?
When did it start?
Days or weeks, constantly there.
What were you doing?
It hurts all the time, doesn’t change with activity.
What happened when you sat down or stopped?
Still hurt.
Where is the pain?
All over.
How long does it last?
Seconds or days
Where does it go?
All over.
What symptoms are associated with it? ROS
Pretty good story…even with no cardiac
history or co-morbid conditions.
The presumptive differential of coronary artery disease is included after the patient's medical history is carefully reviewed, a physical exam is performed, and the patient's symptoms are evaluated.
Due to the potential morbidity and mortality associated with CAD/AMI if it is being considered it must be worked up.
Tests used to confirm a diagnose coronary artery disease include:
electrocardiogram stress tests cardiac catheterization imaging tests such as a chest x ray , echocardiography , or
computed tomography (CT) blood tests to measure blood cholesterol, triglycerides, and other
substances- not to be discussed today.
Pretty good story…even with no cardiac
history or co-morbid conditions.
The presumptive differential of coronary artery disease is included after the patient's medical history is carefully reviewed, a physical exam is performed, and the patient's symptoms are evaluated.
Due to the potential morbidity and mortality associated with CAD/AMI if it is being considered it must be worked up.
Tests used to confirm a diagnose coronary artery disease include:
electrocardiogram stress tests cardiac catheterization imaging tests such as a chest x ray , echocardiography , or
computed tomography (CT) blood tests to measure blood cholesterol, triglycerides, and other
substances
And liability
More History…
Dyspnea on exertion frequently precedes other symptoms of cardiac ischemia or heart failure.
Arrhythmia Duration: sudden short episodes (minutes) suggest paroxysmal tachycardia; longer duration (hours to days) with irregularities suggests atrial dysrhythmia.
Lightheadedness or chest pain while sitting elevates the likelihood of pathology
For MI’s chest pain with associated with radiation, worse with exertion, relieved by rest, nausea, diaphoresis, dyspnea, feeling faint or syncope increase the likelihood of pathology
Is this pain similar to when you had your prior heart attack?
Important History…
Do you have a history of heart disease?
Ever had a heart attack?
Are you diabetic?
Have you ever been worked up for chest pain?
Have you had a stress test?
A cardiac catheterization?
How long ago? Results?
Have you ever had stents placed?
Bypass surgery?
Are you on blood thinners? ASA? Clopidigrel (Plavix)
(or equivalent)? Warfarin?
Important History…
Do you have a history of heart disease?
Ever had a heart attack?
Are you diabetic?
Have you ever been worked up for chest pain?
Have you had a stress test?
A cardiac catheterization?
How long ago? Results?
Have you ever had stents placed?
Bypass surgery?
Are you on blood thinners? ASA? Plavix (or
equivalent)? Warfarin?
The more concerned you
are about cardiac ischemia
the more detail you must
request.
You would think they would
tell you this.
And they will, if you ask.
A Heart Story
As experienced by the
staff of Heart Hospital
Cast
NP
Attending
PA
Intern
Resident
Fellow
Chester
Payne
A Heart Story
The patient has a
good chest pain story.
A Heart Story
The patient has a
good chest pain story.
What are your
initial orders?
A Heart Story
Vital signs, ASA, IV,
Monitoring, Labs
A Heart Story
Good management orders.
A Heart Story
How do we
evaluate his
chest pain?
A Heart Story
What is the gold
standard for
evaluation of
cardiac disease?
A Heart Story
Cardiac
catheterization
A Heart Story
A little premature
at this point.
What shall we
start with?
A Heart Story
EKG?
Electrocardiogram (ECG)
Order routinely in new patients when there is a history of…
Hypertension
CAD
Arrhythmia
Diabetes
Endocrine disorders
Over 50 to establish baseline
Electrocardiogram (ECG)
Order acutely when
patient has ….
Chest pain
Elevated BP
Arrhythmia
Dyspneic
Diaphoretic
Syncopal or near…
Weakness or ? of stroke
A Heart Story
EKG shows NSR, no ST
elevation or depression, no T-
wave inversion, normal
intervals, no Q waves.
A Heart Story
What does that mean?
A Heart Story
No acute cardiac
ischemia or arrhythmia
A Heart Story
Okay group, what should
we order to evaluate his
chest pain?
A Heart Story
Stress test
When To Do Stress Testing
If there are symptoms …..because……
Stress tests have a high degree of accuracy, but…
These tests are not risk free
These tests are not inexpensive $$$$$
So when??
If you have chest pain, shortness of breath, an irregular heartbeat or palpitations, or other symptoms of heart disease.
A case can also be made for people with diabetes or other risk factors who are just starting to exercise.
Stress Test Types
Treadmill test
Exercise test
Non-imaging test
Pharmacological
SPECT (imaging)
When to order what type of stress test?
Exercise
Tracers with imaging
Dobutamine stress?
Non-exercise
Pharmacologicalvs
Exercise testing is superior unless patient unable to use a treadmill.
And the patient must be able to reach 85% maximum heart rate.
Caveat
Increased stress is not
resulting in dilatation,
i.e. ischemia occurs.
Ischemia is everywhere……. Blood flow through exercising skeletal muscles can
be 15 to 20 times greater than through resting muscles.
The increased blood flow is the product of local, nervous, and hormonal regulatory mechanisms.
When skeletal muscle is resting, only 20% to 25% of the capillaries are open, whereas during exercise 100% of the capillaries are open.
Think of peripheral vascular disease, intermittent claudication, ischemic bowel.
Amazing!
The average heart (weighs 10 ounces) beats
72 times per minute
>100,000 times a day
38 million times a year
by 70 a staggering 2.5 billion beats.
Approximately 4-5% of the blood output of the heart goes to the coronary arteries
2.4 ounces/heartbeat
1.3 gallons/minute
1,900 gallons/day
700,000 gallons/year
48 million gallons by 70.
A Heart Story
What type of testing
should we do?
Kohli P , and Gulati M Circulation. 2010;122:2570-2580
There’s an app
for that!
Although this chart from a
paper published in 2010 and
focuses on women the
critical analysis is the same.
A Heart Story
Cardiac
catheterization
A Heart Story
Not yet. What test
should we order ?
A Heart Story
Treadmill with
myocardial imaging.
Exercise Stress Test w/ Myocardial
Imaging
So let’s put our patient
on the treadmill and
see how he does.
We will see how he
exercises
Take some before and
after cardiac images
Compare the results
Stage Minutes % Grade MPH Mets
1 3 10 1.7 5
2 6 12 2.5 7
3 9 14 3.4 10
4 12 16 4.2 13
5 15 18 5.0 15
6 18 20 5.5 18
7 21 22 6.0 20
Bruce Protocol
Maximum Heart Rate (MHR) is typically calculated with the formula
220-age or 220-age X85%.
The test is resulted in the time patient is actively walking on the
treadmill in minutes.
MET Significance MET (metabolic equivalent) is a term used to represent the
intensity of exercise.
One MET equals the uptake of 3.5 ml of oxygen per kilogram of
body weight per minute
1 is the basal rate ( while sleeping)
2 walk 2 mph on level surface
4 4 mph on level surface or
what it takes to perform the activities of daily living.
Poor prognosis if <65
Limit immediate post MI
10 As good a prognosis with medical therapy as CABG
13 Excellent prognosis, regardless of other exercise responses
16 Aerobic master athlete
20 Ultra aerobic athlete
MET Activity Level
Light (<3 ) Moderate (3-6) Heavy (>6)
Sleeping (1.0) Walking briskly Jogging @ 6mph (10)
Walking – slowly (2.0) Cleaning—heavy (3.0–3.5) Shoveling (7.0–8)
Sitting (1-1.5)
Working on computer (1.5)
Windows, vacuuming, mopping Carrying heavy loads (7.5)
Standing Mowing lawn-walk power
mower (5.5)
Bicycling fast @14–16 mph (10.0)
Cooking, washing dishes (2.5) Bicycling @ 10–12 mph) (6.0) Basketball game = 8.0
Fishing-sitting (2.0) Badminton—recreational (4.5) Soccer casual (7.0)
Playing most instruments (2.0–2.5) Tennis—doubles (5.0) Tennis—singles (8.0)
Modified Bruce
Protocol
Starts at a lower workload than the
standard test and is typically used
for elderly or sedentary patients.
It is also used prior to discharging a
NSTEMI patient.
The first two stages of the Modified
Bruce Test are performed at a 1.7
mph and 0% grade and 1.7 mph
and 5% grade
The third stage corresponds to the
first stage of the Standard Bruce
Test protocol.
Absolute Contraindications
Acute myocardial infarction within 48 hours
Unstable angina not yet stabilized with medical therapy
Uncontrolled cardiac arrhythmia, which may have significant hemodynamic responses (e.g. ventricular tachycardia)
Severe symptomatic aortic stenosis, aortic dissection, pulmonary embolism, and pericarditis
Multivessel coronary artery diseases that have a high risk of producing an acute myocardial infarction
Decompensated or inadequately controlled congestive heart failure
Uncontrolled hypertension (blood pressure>200/110mm Hg)
Severe pulmonary hypertension
Acute aortic dissection
Acutely ill for any reason
Severe asthma or COPD
Physically unable to safely complete treadmill test
Relative Contraindications
Known left main coronary artery stenosis
Moderate aortic stenosis
Hypertrophic obstructive cardiomyopathy
Other forms of outflow tract obstruction
Significant tachyarrhythmias or bradyarrhythmias
High-degree atrioventricular block
Electrolyte abnormalities
Mental or physical impairment leading to inability to exercise adequately.
Reliability of an Exercise Stress Test?
If a patient is able to achieve the target heart rate, a regular treadmill stress test is capable of diagnosing important disease in approximately 67% or 2/3 of patients with coronary artery disease.
The accuracy is lower (about 50%) when patients have narrowing in a single coronary artery or higher (greater than 80%) when all three major arteries are involved.
Approximately 10% of patients may have a "false-positive" test (when the result is falsely abnormal in a patient without coronary artery disease).
Exercise stress testing has a lower diagnostic value in patients who cannot achieve an adequate heart rate and blood pressure response.
Diagnostic Value of Various Stress
Testing Modalities in Women
Stress Testing Modality Sensitivity Specificity NPV PPV
Exercise ECG 31-71 66-78 78 47
Exercise Echocardiography 80–88 79-86 98 74
Exercise SPECT 78-88 64-91 99 87
Pharmacological
echocardiography
76-90 85-94 68 94
Pharmacological SPECT 80-91 65-75 90 68
•Values are percentages. PPV indicates positive predictive value.
Diagnostic Value of Various Stress
Testing Modalities in Women
Stress Testing Modality Sensitivity Specificity NPV PPV
Exercise ECG 31-71 66-78 78 47
Exercise Echocardiography 80–88 79-86 98 74
Exercise SPECT 78-88 64-91 99 87
Pharmacological
echocardiography
76-90 85-94 68 94
Pharmacological SPECT 80-91 65-75 90 68
•Values are percentages. PPV indicates positive predictive value.
If an exercise SPECT or exercise echo
is negative, you don’t have it.
Hah!
Radionuclide Imaging
Also known as a nuclear, thallium, Cardiololite or dual isotope stress test, depending upon the method used.
During exercise, healthy coronary arteries dilate (develop a more open channel) more than an artery that has a blockage.
This unequal dilation causes more blood to be delivered to heart muscle supplied by the normal artery.
In contrast, narrowed arteries end up supplying reduced flow to its area of distribution.
This reduced flow causes the involved muscle to "starve" during exercise. The "starvation" may produce symptoms (like chest discomfort or inappropriate shortness of breath), and EKG abnormalities.
When a "perfusion tracer" (a nuclear isotope that travels to heart muscle with blood flow) is injected intravenously, it is extracted by the heart muscle in proportion to the flow of blood.
How is a Nuclear Stress Test Done?
The patient is brought to the patient is placed
under a scanning camera.
Two sets of isotope images are obtained.
One at rest, and one following exercise.
The scanning camera rotates around the patient's chest, stopping to take individual pictures.
The patient needs to lay flat and still during the scanning period which takes approximately 11 to 20 minutes, depending upon the type of scanning camera.
Patients with severe claustrophobia should receive a mild tranquilizer before the test to minimize discomfort.
OR----
Inject the tracer
Take a picture (baseline image)
Stress the patient (physically or
chemically)
Inject more tracer
Take 2nd picture (test image)
Compare the images
The pictures or images are fed into a computer,
which reconstructs them as "slices" of a three
dimensional heart.
Areas that fall out side the expected normal
range is presented as a blacked out area.
How Are Nuclear Stress Images Read?
Area of
hypoperfusion
The pictures or images are fed into a computer,
which reconstructs them as "slices" of a three
dimensional heart.
Areas that fall out side the expected normal
range is presented as a blacked out area.
How Are Nuclear Stress Images Read?
Area of
hypoperfusion
The pictures or images are fed into a computer,
which reconstructs them as "slices" of a three
dimensional heart.
Areas that fall out side the expected normal
range is presented as a blacked out area.
How Are Nuclear Stress Images Read?
Area of
hypoperfusion
And here
The pictures or images are fed into a computer,
which reconstructs them as "slices" of a three
dimensional heart.
Areas that fall out side the expected normal
range is presented as a blacked out area.
How Are Nuclear Stress Images Read?
Area of
hypoperfusion
And here
Here
Pharmacological Stress Test
A chemical stress test combines an intravenous medication with an imaging technique (isotope imaging or echocardiography) to evaluate the LV.
Stress causes normal coronary arteries to dilate, while the blood flow in a blocked coronary artery is reduced.
In these cases, the medication serves as a substitute for exercise by dilating the coronary vessels.
Patients frequently feel flushed or fluttery or short of breath with this medication.
This reduced blood flow may decrease the movement of the affected wall (as seen in a stress echo), or have reduced isotope uptake in a nuclear scan.
Stress Test Report DATE OF STUDY: MM/DD/YYYY REFERRING PHYSICIAN: John Doe, MD
REASON FOR EXAMINATION: Chest pain, shortness of breath and cardiomyopathy.
DESCRIPTION OF PROCEDURE:
The patient exercised on Bruce protocol for 8 minutes and 4 seconds, achieving a heart rate of 142, which is 81% of his age-predicted maximum heart rate. Resting heart rate was 80 with resting blood pressure of 134/92. With exercise, the blood pressure increased to 169/94 and the heart rate increased to 142.
Electrocardiogram at rest revealed sinus rhythm with voltage criteria for left
ventricular hypertrophy with repolarization changes. With exercise, no significant electrocardiographic changes were noted. The patient stopped due to fatigue and shortness of breath and did not have exercise-induced chest pain.
IMPRESSION:
1. Average exercise capacity.
2. Somewhat blunted heart rate response secondary to beta-blocker use.
3. Normal blood pressure response.
4. No clinical or electrocardiographic changes consistent with myocardial ischemia noted during this exercise stress test.
5. Sestamibi imaging results will be reported separately
Stress Test Report DATE OF STUDY: MM/DD/YYYY REFERRING PHYSICIAN: John Doe, MD
REASON FOR EXAMINATION: Chest pain, shortness of breath and cardiomyopathy.
DESCRIPTION OF PROCEDURE:
The patient exercised on Bruce protocol for 8 minutes and 4 seconds, achieving a heart rate of 142, which is 81% of his age-predicted maximum heart rate. Resting heart rate was 80 with resting blood pressure of 134/92. With exercise, the blood pressure increased to 169/94 and the heart rate increased to 142.
Electrocardiogram at rest revealed sinus rhythm with voltage criteria for left
ventricular hypertrophy with repolarization changes. With exercise, no significant electrocardiographic changes were noted. The patient stopped due to fatigue and shortness of breath and did not have exercise-induced chest pain.
IMPRESSION:
1. Average exercise capacity.
2. Somewhat blunted heart rate response secondary to beta-blocker use.
3. Normal blood pressure response.
4. No clinical or electrocardiographic changes consistent with myocardial ischemia noted during this exercise stress test.
5. Sestamibi imaging results will be reported separately
This information can be
helpful in evaluating study.
Stress Test Report DATE OF STUDY: MM/DD/YYYY REFERRING PHYSICIAN: John Doe, MD
REASON FOR EXAMINATION: Chest pain, shortness of breath and cardiomyopathy.
DESCRIPTION OF PROCEDURE:
The patient exercised on Bruce protocol for 8 minutes and 4 seconds, achieving a heart rate of 142, which is 81% of his age-predicted maximum heart rate. Resting heart rate was 80 with resting blood pressure of 134/92. With exercise, the blood pressure increased to 169/94 and the heart rate increased to 142.
Electrocardiogram at rest revealed sinus rhythm with voltage criteria for left
ventricular hypertrophy with repolarization changes. With exercise, no significant electrocardiographic changes were noted. The patient stopped due to fatigue and shortness of breath and did not have exercise-induced chest pain.
IMPRESSION:
1. Average exercise capacity.
2. Somewhat blunted heart rate response secondary to beta-blocker use.
3. Normal blood pressure response.
4. No clinical or electrocardiographic changes consistent with myocardial ischemia noted during this exercise stress test.
5. Sestamibi imaging results will be reported separately
How well the patient was
able to complete the test .
Stress Test Report DATE OF STUDY: MM/DD/YYYY REFERRING PHYSICIAN: John Doe, MD
REASON FOR EXAMINATION: Chest pain, shortness of breath and cardiomyopathy.
DESCRIPTION OF PROCEDURE:
The patient exercised on Bruce protocol for 8 minutes and 4 seconds, achieving a heart rate of 142, which is 81% of his age-predicted maximum heart rate. Resting heart rate was 80 with resting blood pressure of 134/92. With exercise, the blood pressure increased to 169/94 and the heart rate increased to 142.
Electrocardiogram at rest revealed sinus rhythm with voltage criteria for left
ventricular hypertrophy with repolarization changes. With exercise, no significant electrocardiographic changes were noted. The patient stopped due to fatigue and shortness of breath and did not have exercise-induced chest pain.
IMPRESSION:
1. Average exercise capacity.
2. Somewhat blunted heart rate response secondary to beta-blocker use.
3. Normal blood pressure response.
4. No clinical or electrocardiographic changes consistent with myocardial ischemia noted during this exercise stress test.
5. Sestamibi imaging results will be reported separately
Baseline EKG. Good information to have.
Stress Test Report DATE OF STUDY: MM/DD/YYYY REFERRING PHYSICIAN: John Doe, MD
REASON FOR EXAMINATION: Chest pain, shortness of breath and cardiomyopathy.
DESCRIPTION OF PROCEDURE:
The patient exercised on Bruce protocol for 8 minutes and 4 seconds, achieving a heart rate of 142, which is 81% of his age-predicted maximum heart rate. Resting heart rate was 80 with resting blood pressure of 134/92. With exercise, the blood pressure increased to 169/94 and the heart rate increased to 142.
Electrocardiogram at rest revealed sinus rhythm with voltage criteria for left ventricular
hypertrophy with repolarization changes. With exercise, no significant electrocardiographic changes were noted. The patient stopped due to fatigue and shortness of breath and did not have exercise-induced chest pain.
IMPRESSION:
1. Average exercise capacity.
2. Somewhat blunted heart rate response secondary to beta-blocker use.
3. Normal blood pressure response.
4. No clinical or electrocardiographic changes consistent with myocardial ischemia noted during this exercise stress test.
5. Sestamibi imaging results will be reported separately
Did the patient stop
prematurely?
Stress Test Report DATE OF STUDY: MM/DD/YYYY REFERRING PHYSICIAN: John Doe, MD
REASON FOR EXAMINATION: Chest pain, shortness of breath and cardiomyopathy.
DESCRIPTION OF PROCEDURE:
The patient exercised on Bruce protocol for 8 minutes and 4 seconds, achieving a heart rate of 142, which is 81% of his age-predicted maximum heart rate. Resting heart rate was 80 with resting blood pressure of 134/92. With exercise, the blood pressure increased to 169/94 and the heart rate increased to 142.
Electrocardiogram at rest revealed sinus rhythm with voltage criteria for left
ventricular hypertrophy with repolarization changes. With exercise, no significant electrocardiographic changes were noted. The patient stopped due to fatigue and shortness of breath and did not have exercise-induced chest pain.
IMPRESSION:
1. Average exercise capacity.
2. Somewhat blunted heart rate response secondary to beta-blocker use.
3. Normal blood pressure response.
4. No clinical or electrocardiographic changes consistent with myocardial ischemia noted during this exercise stress test.
5. Sestamibi imaging results will be reported separately
This is certainly an
encouraging report
but the real answer is
in the images.
. Normal Nuclear Imaging Results
MYOCARDIAL PERFUSION IMAGING:
1. The overall quality of the scan was good.
2. There was no diagnostic abnormality on rest and stress myocardial perfusion imaging.
3. The left ventricular cavity appeared normal in size.
4. Gated SPECT images revealed no wall motion abnormalities.
5. Overall left ventricular systolic function was normal with calculated left ventricular ejection fraction of 60% at rest.
This is a good
result.
. Normal Nuclear Imaging Results
MYOCARDIAL PERFUSION IMAGING:
1. The overall quality of the scan was good.
2. There was no diagnostic abnormality on rest and stress myocardial perfusion imaging.
3. The left ventricular cavity appeared normal in size.
4. Gated SPECT images revealed no wall motion abnormalities.
5. Overall left ventricular systolic function was normal with calculated left ventricular ejection fraction of 60% at rest.
This is a good
result.
Supported by good
LV function.
. Abnormal Nuclear Imaging Results
MYOCARDIAL PERFUSION IMAGING:
1. The overall quality of the scan was good.
2. There was a fixed perfusion defect in the apex and a reversible perfusion defect in the anterior left on stress myocardial perfusion imaging.
3. The left ventricular cavity appeared normal in size.
4. Gated SPECT images revealed mild septal hypokinesis and mild-moderate apical hypokinesis. Overall left ventricular systolic function was low with calculated ejection fraction of 40% at rest.
Fixed perfusion
defect means old.
. Abnormal Nuclear Imaging Results
MYOCARDIAL PERFUSION IMAGING:
1. The overall quality of the scan was good.
2. There was a fixed perfusion defect in the apex and a reversible perfusion defect in the anterior left on stress myocardial perfusion imaging.
3. The left ventricular cavity appeared normal in size.
4. Gated SPECT images revealed mild septal hypokinesis and mild-moderate apical hypokinesis. Overall left ventricular systolic function was low with calculated ejection fraction of 40% at rest.
Reversible means a lesion that is
likely causing the symptoms.
. Abnormal Nuclear Imaging Results
MYOCARDIAL PERFUSION IMAGING:
1. The overall quality of the scan was good.
2. There was a fixed perfusion defect in the apex and a reversible perfusion defect in the anterior left on stress myocardial perfusion imaging.
3. The left ventricular cavity appeared normal in size.
4. Gated SPECT images revealed mild septal hypokinesis and mild-moderate apical hypokinesis. Overall left ventricular systolic function was low with calculated ejection fraction of 40% at rest.
Hypokinesis is loss of
contractility. If permanent it is
from an old infarct.
. Abnormal Nuclear Imaging Results
MYOCARDIAL PERFUSION IMAGING:
1. The overall quality of the scan was good.
2. There was a fixed perfusion defect in the apex and a reversible perfusion defect in the anterior left on stress myocardial perfusion imaging.
3. The left ventricular cavity appeared normal in size.
4. Gated SPECT images revealed mild septal hypokinesis and mild-moderate apical hypokinesis. Overall left ventricular systolic function was low with calculated ejection fraction of 40% at rest.
Hypokinesis can be a result of
stunned myocardium in an
acute event and be reversible.
MUGA Scans
Using this scan the gamma camera acquires a series of pictures of the heart in synchrony with the patients ECG signals. The pictures record the heart's motion and determine if all of its segments are contracting properly. MUGA scanning may take 2 to 3 hours to obtain all the needed views and can be done both before and after you exercise.
Multigated acquisition (MUGA) scans are used routinely before and after receiving a heart transplant to assess how well the heart is working.
MUGA is also used to monitor the ejection fraction in people receiving chemotherapy, especially those receiving doxorubicin (Adriamycin).
However a MUGA does not provide information about the heart valves or the thickness of the ventricle.
A Heart Story
Cardiology Fellow, please
present the case for Dr. Z.
A Heart Story
48 yom with known CAD, DM uncontrolled presents with
substernal chest pain that is non-radiating. EKG, labs WNL but
myocardial perfusion scan shows perfusion defects.
A Heart Story
Excellent summary. So Dr. Z what do you want to do?
A Heart Story
Cardiac
catheterization.
Cardiac Catheterization
Cardiac catheterization or coronary angiography are invasive, diagnostic procedures that are performed to obtain information about the heart or its blood vessels.
These procedures involve directing a catheter or catheters into the right and/or heart chambers and into the origin of the coronary arteries.
During cardiac catheterization the pressure and blood flow in the cardiac chambers are measured.
Blood in these different chambers can also be collected to look for shunts or abnormal connections between chambers.
During coronary angiography contrast material is directly injected into the coronary arteries and the subsequent image recorded on x ray.
Cardiac Catheterization Indications
Cardiac catheterization is performed:
To determine whether the coronary arteries are
obstructed or narrowed.
To determine the severity of the coronary stenosis,
the number of coronary arteries involved and their
location.
To evaluate the severity of valve dysfunction.
Determine the need for cardiac surgery.
To evaluate congenital cardiac abnormalities.
Cardiac Cath Lab
Fluoroscopy is used to
visualize the vessels when
the dye is injected.
These images are saved
for review following the
procedure.
If blockages are found
angioplasty can be done
immediately.
Coronary Angiography
Angioplasty
Depending on the
severity of the lesions,
their locations the
decision is made
whether or not to try
angioplasty with
balloon or stent
placement or
schedule the patient
for bypass graft
surgery.
CABG
Coronary Artery Bypass Grafting
Whose coronary artery disease cannot be
adequately treated by cardiac medications
Cannot be treated with angioplasty
Who suffer from intractable or unstable angina
Other individuals who may
benefit from CABG after a
heart attack include those who
are suffering from cardiogenic
shock or who remain unstable
after PTCA.
While bypass surgery can limit
damage in people with an
acute heart attack, it does not
cure the underlying coronary
artery disease.
Many still require medications
after CABG. Lifestyle
modification and cardiac
rehabilitation is recommended.
Bypass surgery is performed in people
•With an evolving heart attack when pain and ECG findings are unstable
•Who failed angioplasty (They still have persisting pain or continue to be unstable after angioplasty)
•Who are undergoing repair of mechanical complications such as a tear in the wall dividing the ventricles (ventricular septal defect) or heart valve insufficiency ("leaky" heart valves)
CABG
Coronary Artery
Bypass Grafting
•These individuals usually have
•significant obstruction of the
three main coronary arteries
significant obstruction of the
left main artery
•depressed pumping action or
blockage of the left anterior
descending artery
Alternative Techniques
In off-pump coronary artery bypass or OPCAB,
bypass grafting is performed without the use of
the heart-lung machine. Surgery is performed
while the heart is still beating, although the heart
rate is slowed and the heart partially held in place
using surgical instruments.
Another alternative is the use of smaller incisions
that avoids splitting the breastbone. This is
referred to as Minimally Invasive Direct Coronary
Artery Bypass or MIDCAB.
If you didn’t enter
it in the chart it
didn’t happen.
If it can’t be read,
it didn’t happen
And the rest of the story …..
Get off me!!
I fainted because I
just won the lottery!!
Arrhythmias
Arrhythmias can be difficult to evaluate when they are episodic.
Mr. Dude the palpitations you describe
have not been seen on telemetry.
Arrhythmias
Arrhythmias can be difficult to
evaluate when they are episodic
Mr. Dude the palpitations you describe
have not been seen on telemetry.
What can we do? I can’t
stay in the hospital forever.
Arrhythmias
Arrhythmias can be difficult to
evaluate when they are episodic
Mr. Dude the palpitations you describe
have not been seen on telemetry.
What can we do? I can’t
stay in the hospital forever.
Let’s order an
event monitor.
Holter Monitor
A continuous tape recording of a patient's EKG.
Since it can be worn during the patient's regular daily activities, it helps the physician correlate symptoms of dizziness, palpitations (a sensation of fast or irregular heart rhythm) or black outs.
It is much more likely to detect an abnormal heart rhythm when compared to the EKG which lasts less than a minute.
It can also help evaluate the patient's EKG during episodes of chest pain, during which time there may be telltale changes to suggest ischemia
Commonly worn for 24 hours there are versions that can be worn 3-4 weeks (called event monitors).
Holter
Monitor
Implantable Cardiac Monitors
In cases where the patient is profoundly (such as syncope)but infrequently symptomatic an implantable monitor can be inserted under the skin.
Called loop recorders
Ms. Smithers
have you even
been told you
have a heart
murmur?
EchocardiogramMs. Smithers
have you even
been told you
have a heart
murmur?
No.
I will order an
echocardiogram.
Echocardiography
What is an Echocardiogram: An echocardiogram is a test in which ultrasound is used to examine the heart.
In addition to providing single-dimension images, known as M-mode echo that allows accurate measurement of the heart chambers, the echocardiogram also offers far more sophisticated and advanced imaging.
This is known as two- dimensional (2-D) Echo and is capable of displaying a cross-sectional "slice" of the beating heart, including the chambers, valves and the major blood vessels that exit from the left and right ventricle
Echocardiogram Evaluates-
Heart size
Heart function or ejection fraction
Presence of cardiac malformations
Presence of ventricular aneurysms
Presence of scars
Valve morphology
Presence of masses in the heart or
on the valves
Presence of pericardial fluid
Left Ventricular FunctionHyperdynamic Normal Mild LV
dysfunction
Moderate LV
dysfunction
EF (%) >65 55-65 45-54 30-44
Chest wall
LR
Echocardiography
Color-Flow Echocardiogram: This is the part of the Doppler
echocardiogram where we can determine the direction
of blood flow according to the color on the screen
.
Blood going away from the transducer looks blue, while
blood coming towards the echocardiogram transducer
looks red.
In addition, there may be a mosaic of colors if there is
turbulent flow as may be seen across a narrow blood
vessel or heart valve.
This is also helpful in detecting a leaky valve or a hole in
the heart.
This is a very sensitive instrument that may pick up a very
mild degree of leakage in normal heart valves.
This is what we call physiologic regurgitation (leakage).
Virtually all normal human beings have physiologic
regurgitation in one or more heart valves. The quality of the
study is somewhat
operator dependent.
Transesophageal Echocardiogram
A TEE is extremely useful in detecting blood clots, masses and tumors that are
located inside the heart.
It can also gauge the severity of certain valve problems and help detect
infection of heart valves, certain congenital heart diseases (like a hole
between the upper chambers of the heart, known as an ASD or atrial septal
defect) and a tear (dissection) of the aorta (major artery of the body).
TEE is also very useful in evaluating for clots inside the left atrium.
Resources
Articles on Chest Pain History
jama.jamanetwork.com/article.aspx?articleid=201900
www.ncbi.nlm.nih.gov/pmc/articles/PMC481842/
American College of Cardiology
www.cardiosource.org/acc
American Heart Association
www.heart.org
Up to Date
www.uptodate.com
Questions?