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Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

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Missed Opportunities to Diagnose COPD Daryl Freeman on behalf of the Study Collaborators
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Page 1: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Missed Opportunities to Diagnose COPD

Daryl Freemanon behalf of the Study Collaborators

Page 2: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

CollaboratorsResearch in Real Life, Cambridge

David Price

Julie von Ziegenweidt

Laurence Mascarenhas

Annie Burden

Alison Chisholm

Independent experts

David Halpin: Royal Devon and Exeter Foundation Trust, Exeter, UK

Eric Batemen: University of Cape Town, Cape Town, South Africa

Daryl Freeman: Mundesley Medical Practice, Norfolk, UK

Dermot Ryan: Woodbrook Medical Centre, Loughborough, UK

Rupert Jones: PeninsulaCollege of Medicine and Dentistry, University of Plymouth, UK

Respiratory Programme, Department of Health, UK

Robert Winter

Sue Hill

Kevin Holton

Anne Moger

Matthew Kearney

Page 3: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Diagnostic iceberg

• Among smokers with no prior history of obstructive lung disease, 18.7% have COPD1

• Amongst patients currently treated with asthma therapy and no diagnosis of COPD, 24.5% have COPD2

Tinkelman DG, Price DB, Nordyke RJ, Halbert RJ. Misdiagnosis of COPD and Asthma in Primary Care Patients 40 Years of Age and Over. J Asthma. 2006;43:75-80.

Page 4: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Population studies consistently demonstrate underdiagnosis of COPD is high

1. Soriano et al. Lancet 2009

Estimates of COPD underdiagnosis are substantially higher than those forhigh blood pressure, hypercholesterolemia and other similar disorders1

Cáceres,

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)

100

80

60

40

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Underdiagnosis (%

)

DiagnosedUndiagnosed

% underdiagnosis

Page 5: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Dr Daryl Freeman

• Conflict of interests– DF has received honaria for speaking from

• AZ, BI, Napp, Novartis,Meda,Chiesi,Teva, Almirall

– DF has received educational support/grants/attendance at conferences from

• Napp, Teva, AZ, Pfizer

Page 6: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Daryl Freeman

Page 7: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Missed Opportunities

• Missed opportunities to identify patients in Primary Care

• Co- morbidities: should we screen for COPD in our CDM clinics?

• Questionnaires vs Opportunistic screening

How can we identify more patients with a COPD Diagnosis?

Page 8: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

MISSED OPPORTUNITIES

Page 9: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

COPD: mis- and under-diagnosed disease• UK Department of Health’s National COPD

Outcomes Strategy1, states that around:– 835,000 are currently diagnosed with COPD in England – 2,200,000 undiagnosed COPD

• Screening study in patients >40 years2

undiagnosed spirometrically-defined COPD in:– 1/5 of smokers – 1/4 of “asthma” patients

1. Department of Health. 2011. http://www.dh.gov.uk/publications 2. Tinkelman DG, Price DB, Nordyke RJ, Halbert RJ. J Asthma 2006;43(1):75–80

Page 10: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

COPD in the UK: National Strategy• The Outcomes Strategy was published by the UK

Department of Health in July 2011.1

– Provides a framework for achieving improvements in COPD outcomes in England.

– Notes that too many people are being diagnosed too late in the disease to the detriment of the NHS and patients.

1. Department of Health 2011. http://www.dh.gov.uk/publications

Page 11: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Study rationale

• Early diagnosis and intervention in the management of symptomatic COPD may reduce:1

– Impact on patients • Exacerbation reduction• Lung function decline

– Rate of disease progression– Economic burden on health systems.

1. Price D, Freeman D, Cleland J, Kaplan A, Cerasoli F. Prim Care Resp J. 2011;20(1):15-22.

Page 12: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Aim

• To use large primary care clinical databases to:– Characterise the current COPD population– Ascertain the stage at presentation – Evaluate the consultation pattern prior to

diagnosis– Identify flags to aid in earlier diagnosis

Page 13: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Methods

• Retrospective observational study• Routine practice data (1990 - 2009) • Pooled from the databases

– General Practice Research Database (GPRD) www.gprd.com

– Optimum Patient Care Research Database (OPCRD) www.optimumpatientcare.org

Page 14: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Inclusion criteria

• Aged ≥40 years• Received a COPD diagnosis between 1990–

2009 (i.e. a Read Code for COPD)

• Minimum 3 year continuous practice data:– ≥2 years pre diagnosis– ≥1 year post diagnosis

• On current COPD therapy:– ≥2 COPD prescriptions in the year after COPD

diagnosis

Page 15: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Patient inclusion Flow Chart

Exclusion Criteria: 1) Age ≤40

1,220

2) Inadequate data12,458

3) ≤1 COPD prescription in the year after COPD diagnosis

13,655

Exclusion Criteria:1) Diagnosed prior 1990

2) <12 months of outcome data after diagnosis

9,452

FIRST COPD diagnosis after 1990 66,232

Meet inclusion criteria38,859

OPCRD 10,876GPRD 27,983

.

COPD Diagnosed patients 75,984

All Patients1,122,787

OPCRD 307,410GPRD 815,377

Page 16: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Study population = 38,859

Gender (male) 52.6%

Smoking status(data from 73%)

Non-smoker 8.9%

Current Smoker 45.7%

Ex-smoker 45.4%

Page 17: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Severity of COPD at time of diagnosis (available in 38%)

24% of all patients had FEV1/FVC ≥0.7:

– All had clinical diagnosis but not spirometrically confirmed

– Of these 54% have FEV1 % predicted 50–80%

FEV1 /FVC Ratio ≥ 0.7

Mild (FEV1 ≥ 80%)

Moderate (50% ≤ FEV1<

80%)

Severe (30% ≤ FEV1< 50%)

Very Severe (FEV1 ≤ 30%)

0

5

10

15

20

25

30

35

40

45

Pe

rce

nta

ge

of

pa

tie

nts

Page 18: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Severity at diagnosis over 20yrs

13 January 2011 COPD strategy database analysis 19

COPD CDM payment started

Page 19: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Age

40-49 50–59 60–69 70–79 80–89 90–99 ≥1000

5

10

15

20

25

30

35

4.9%

18.2%

32.6% 31.8%

11.6%

0.9% 0

Age distribution

Age category (years)

Pe

rce

nta

ge

of

pa

tie

nts

Median age 68 years (IQR 60-75 years)

Page 20: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Age of diagnosis over 20yrs

• Age of diagnosis is not changing in any severity category

Page 21: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Lower respiratory consultations in 2 years prior to COPD diagnosis

On average patients visited their general practitioner:

• For lower respiratory (LR) symptoms 2.8 times

• 56% had ≥2 consultations for LR symptoms

• 21% had at least 5 consultations

In our practice patients who have a smoking history and present with LRTI symptoms are referred for spirometry

when stable

Page 22: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Lower respiratory symptom consultations over time

•Mean number of LR symptom consultations / patient / year increased over 20 yrs before diagnosis:– 20 yrs: 0.01– 10 yrs: 0.25– 5 yrs: 0.53– 1 yr: 1.85

-20 -19 -18 -17 -16 -15 -14 -13 -12 -11 -10 -9 -8 -7 -6 -5 -4 -3 -2 -10

0.2

0.4

0.6

0.8

1

1.2

1.4

1.6

1.8

2

Years prior to receiving a COPD diagnosis

Me

an

nu

mb

er

of

LR

co

ns

ult

ati

on

s /

pt

/ y

ea

r

Page 23: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Exacerbation frequency in 2 yrs before diagnosis and LR consultations over 10yrs

-10 -9 -8 -7 -6 -5 -4 -3 -2 -10

10

20

30

40

50

60

70

80

0–1 exacerbations in the 2 years prior to COPD diagnosis

≥2 exacerbations in the 2 years prior to COPD diagnosis

Years prior to COPD diagnosis

Pe

rce

nt

of

pa

tie

nts

wit

h ≥

2 a

nn

ua

l L

RT

I c

on

slu-

tati

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s

Page 24: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Persistent exacerbation phenotype in COPD

For patients with multiple exacerbations in the year before diagnosis : • Odds ratio of ≥2 exacerbations in the:

• Further analyses planned to investigate whether treatment reduces the exacerbation frequency in such people

OR (95% CI)

First year after diagnosis 4.34 (4.13, 4.57)*

Second year after diagnosis 3.54 (3.36, 3.73)**

* Adjusted for age, gender, place of diagnosis & year of diagnosis ** Adjusted for age, gender & year of diagnosis

Page 25: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Chest X-rays over time

-20-19-18-17-16-15-14-13-12-11-10 -9 -8 -7 -6 -5 -4 -3 -2 -10

0.05

0.1

0.15

0.2

0.25

0.3

Years prior to COPD diagnosis

Me

an

nu

mb

er

of

Ch

es

t X

-ra

ys

/ p

a-

tie

nt

/ y

ea

r• Over the 20 years preceding their COPD diagnosis, Chest X-rays increase steadily• In 2 yrs before diagnosis:

o 22% had a Chest X-ray, 7% >1 chest X-rays

Page 26: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Primary vs secondary care diagnosis • The majority of patients are diagnosed in primary care:

99% (n=38,480) versus 1% (n=379)

• Multiple “COPD exacerbations” in the 2 yrs before diagnosis occurred in:– 41% diagnosed in secondary care – 35% diagnosed in primary care (p=0.007)

• Diagnosis in secondary care is usually late and represents delayed diagnosis

Page 27: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

So has there been progress over 20 years?

• Early diagnosis is slowly improving.• In a large dataset we have shown in 2yrs before

diagnosis, there are opportunities to diagnose COPD– 56% consulted multiple times for LR symptoms– 26% consulted multiple times for LRTIs:– 22% of patients had a chest X-ray– Consultations increase in frequency prior to diagnosis– Diagnosis in secondary care is usually late

Page 28: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

CO- MORBIDITIES: SHOULD WE SCREEN FOR COPD IN OUR CDM CLINICS?

Page 29: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Co-morbidities of COPD

COPD

Page 30: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Co-morbidities of COPD

COPD

UNRELATED

OsteoarthritisCirrhosis

Page 31: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Co-morbidities of COPD

COPD

UNRELATED

OsteoarthritisCirrhosis

SHARED RISK

Lung CancerCardiovascular

Page 32: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Co-morbidities of COPD

COPD

UNRELATED

OsteoarthritisCirrhosis

THERAPY

OsteoporosisDiabetes

SHARED RISK

Lung CancerCardiovascular

Page 33: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Co-morbidities of COPD

COPD

UNRELATED

OsteoarthritisCirrhosis

SYSTEMICCONSEQUENCES

CardiovascularMuscle Dysfunction

Metabolic Syndrome

THERAPY

OsteoporosisDiabetes

SHARED RISK

Lung CancerCardiovascular

Page 34: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Accelerated ageing may underlieboth COPD and co-morbidities

Cigarette smoke and other pollutants may accelerate lung aging

ROS = reactive oxygen species Ito et al. Chest 2009

Senescence ROS

mitochondria

InflammationStructural change

Increased risk of cancerCell death

Normal aged lung (senile lung) Accelerated aged lung (COPD lung)

Environmental ROS (Tobacco, kitchen smoke)

DNA damage Kinase activation (MAPK, PI3K

NFkB activation Oxidation/nitration of proteins,

Reduction of anti-aging molecules (sirtuin, HDAC etc.),

Telomere shortening, Defect of proteasome etc…

Page 35: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

COPD is associated with a high prevalence of co-morbidities

Patie

nts

with

CO

PD re

porti

ng c

ondi

tion

(%)

Hypertension Hyper-cholesterolemia

Depression Cataracts Osteoporosis

Data from telephone survey carried out among 1,003 US patients with COPD in 2006

5357

54

49

44

2731 32

39

12

60

50

40

30

20

10

0

Barr et al. Am J Med 2009

Page 36: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Cardiovascular mortality in COPD

For every 10 % decrease in FEV1 in mild to moderate

COPD:

•Cardiovascular mortality increases by 28%

•Non-fatal coronary events increase by 20%

Anthonisen et al, AJRCCM 2002

Page 37: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Co-morbidities of COPD

COPD

UNRELATED

OsteoarthritisCirrhosis

SYSTEMICCONSEQUENCES

CardiovascularMuscle Dysfunction

Metabolic Syndrome

THERAPY

OsteoporosisDiabetes

SHARED RISK

Lung CancerCardiovascular

Page 38: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Diabetes

• Diabetes is highly prevalent among patients with COPD – Proportion of patients:

• 13–22%1 • 25–26%2

• Patients with COPD have a 2-fold greater risk of diabetes than individuals without COPD3

1. Sin et al. Circulation 2003; 2. Barr et al. Am J Med 2009; 3. Feary et al. Thorax 2010; 4. Mellbin et al. Eur J Cardiovasc Prev Rehabil 2010

Page 39: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Anxiety and Depression

• Both major comorbidities in COPD1–4

– Associated with poor prognosis4,5

• Estimates vary on prevalence of depression (8–80%) and anxiety (6–64%) in COPD2,6

– Lack of methodological consensus

• Abnormal (≥10 points) Hospital Anxiety and Depression Scale (HADS) scores in COPD patients (n=701) entering pulmonary rehabilitation:7

– Anxiety: 32%– Depression: 27%

1. Hanania et al. Am J Respi Crit Care Med 2011; 2. Kunik et al. Chest 2005; 3. Maurer et al. Chest 2008; 4. Ng et al. Arch Intern Med 2007; 5. Eiser et al. Thorax 2010;

6. Yohannes et al. Int J Geriatr Psychiatry 2010; 7. Janssen et al. Chron Respir Dis 2010

Page 40: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Active comorbidities at the time of diagnosis of COPD

A collaborative observational study carried out by the UK Department of Health and Research in Real Life collaborative

and independent respiratory experts

Page 41: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

CollaboratorsDavid Price: Centre of Academic Primary Care, University of Aberdeen, UK; Research in Real Life, Cambridge, UK

David Halpin: Royal Devon and Exeter Foundation Trust, Exeter, UK

Robert Winter: Respiratory Programme, Department of Health, UK; East of England Strategic Health Authority, UK

Sue Hill: Respiratory Programme, Department of Health, UK

Eric Batemen: University of Cape Town, Cape Town, South Africa

Daryl Freeman: Mundwsley Medical Centre, Norfolk, UK

Dermot Ryan: Woodbrook Medical Centre, Loughborough,and University of Edinburgh, UK

Matthew Kearney: Respiratory Programme, Department of Health, UK;

Kevin Holton: Respiratory Programme, Department of Health, UK

Anne Moger: Respiratory Programme, Department of Health, UK

Julie von Ziegenweidt: Research in Real Life, Cambridge, UK

Laurence Mascarenhas: Research in Real Life, Cambridge, UK

Annie Burden: Research in Real Life, Cambridge, UK

Alison Chisholm: Research in Real Life, Cambridge, UK

Rupert Jones: Peninsula Medical School, University of Plymouth, UK

Page 42: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

COPD in the UK: National Strategy• An Outcomes Strategy for Chronic Obstructive Pulmonary Disease

(COPD) and Asthma in England was published by the Department of Health in July 2011.1

• The Strategy:1

– Provides a framework for achieving a significant improvement in outcomes for the estimated three million people in England who live with COPD.

– Highlights that COPD is often associated with other conditions, e.g.:• ~40% of people with COPD also have heart disease• Significant numbers have depression and/or anxiety disorder

– Calls for:• Assessment and effective interventions using a holistic care approach where

comorbidities predate the COPD• A holistic approach to monitoring other conditions that may present after the COPD

diagnosis 1. Department of Health. An Outcomes Strategy for Chronic Obstructive Pulmonary Disease (COPD) and Asthma in England. 18 July 2011. Available online at: http://www.dh.gov.uk/publications

Page 43: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Study objective• The research team’s objective was to evaluate the presence of active

comorbidities at the time of patients’ COPD diagnosis. Namely, comorbid:– Asthma– Ischaemic heart disease (IHD)

• Heart Failure, or• Angina, or • Myocardial Infarction

– Gastro-oesophageal reflux disease (GERD) – Diabetes mellitus (DM) – Osteoporosis– Sinusitis– Allergic Rhinitis– Depression and anxiety– Chronic pain

Dermot Ryan
should this be depression/anxiety?
Page 44: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Study rationale

• Comorbidities can potentiate the morbidity of COPD, and vice versa.

• Patients with COPD often die as a result of a comorbidities.

• Understanding the prevalence of comorbidities will help quantify the extent of disease burden of patients living with COPD.

Page 45: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Study design and data• Retrospective observational study using routine

practice data (between 1990 and 2009) pooled from: – General Practice (GPRD)

• Well-validated Primary care database• Anonymised, longitudinal data • Routine clinical data

– Optimum Patient Care Research Databases (OPCRD)• Anonymised data extracted from practices during records-based clinical reviews,

contains: Routine clinical data Patient reported data

• Has been approved by Trent Multi Centre Research Ethics Committee for clinical research use

Page 46: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Inclusion criteria

• Included in the dataset were all patients who were:– Aged ≥40 years– Received a COPD diagnosis between 1990–2009 (i.e. a Read

Code for COPD)

• Minimum 3 year continuous practice data:– ≥2 years pre diagnosis– 1 year post diagnosis

• On current COPD therapy:– ≥2 COPD prescriptions in the year after COPD diagnosis

Page 47: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Data extraction CONSORT

Exclusion Criteria: 1) Age ≤40 OPCRD (n = 660) GPRD (n = 560)

2) Patients without 2 years’ data prior to and 1 year’s data after diagnosis. OPCRD (n=3,391) GPRD (n = 9,107)

3) ≤1 COPD prescription in the year after COPD diagnosis (any of SABA / LABA / ICS / SAAC / LAAC / LTRA / THEO) OPCRD (n= 3,884) GPRD (n = 9,771)

Valid COPD Patients(n = 38,859)

OPCRD (n = 10,876)GPRD (n = 27,983)

Exclusion Criteria:1) Patients whose COPD was diagnosed prior 1990

2) Patients without ≥12 months of outcome data after their COPD diagnosis OPCRD (n = 4,291) GPRD (n = 5,161) FIRST COPD diagnosis after 1990

OPCRD (n = 18,811)GPRD (n =47,421)

Identify patients with valid inclusion criteria

1)Age >402)At least 2 years’ of data pre diagnosis and 1 year’s data post diagnosis 3)At least 2 prescriptions for COPD therapy after COPD diagnosis.

COPD Diagnosed patients

OPCRD (n = 23,102)GPRD (n =52,582)

All PatientsOPCRD (n = 307,410)GPRD (n = 815,377)

Page 48: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Study population• Active comorbidities at the time of COPD diagnosis were defined

as follows:

Comorbidity Defined as

Asthma

Diagnostic Code ever prior to COPD diagnosisIschaemic Heart Disease

Osteoporosis

Diabetes Mellitus Diagnostic Code ever prior OR drugs ever prior to COPD diagnosis

GERD

Diagnostic Code in 2 years prior to COPD diagnosis OR diagnostic code ever prior plus drugs in the 2 years prior to COPD diagnosis

Allergic Rhinitis

Sinusitis

Depression / Anxiety

Chronic Pain ≥3 analgesic prescriptions in the 2 years prior to COPD diagnosis

Page 49: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Summary characteristic• A total of 38,859 patients were included in the study

PATIENT CHARACTERISTIC

Sex (male) 52.6%

AgeMean 67.5 (10.4) yearsMedian (IQR) 68 (60, 75) years

Severity of COPD at diagnosis*(data available in 37.8% of patients)

FEV1/FVC ≥ 0.7** 24.3%Mild (FEV1 ≥ 80%) 6.6%Moderate (50% ≤ FEV1< 80%) 38.4%Severe (30% ≤ FEV1< 50%) 24.3%Very Severe (FEV1 ≤ 30%) 5.8%

Smoking status(data available for 73.1% of patients)

Non-smoker 8.9%Current Smoker 45.7%Ex-smoker 45.4%

*Based on FEV1 and GOLD criteria; over the period of this study (1999–2009), CAT scores were recorded in only 4.1% of patients**Of the 24.3% of patients with FEV1/FVC ≥0.7: 65% have ratios between 0.7–0.8 and 54% have FEV1 percent predicted of 50–80%, i.e. would be classified as moderate

Page 50: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Prevalenceof comorbidities(I)

COMORBIDITY Percent of patients

GERD 6.5%

Depression and Anxiety 15.8%

Sinusitis 5.7%

Allergic rhinitis 6.6%

Diabetes Mellitus 18.3%

Ischaemic Heart Disease Diagnosis* 14.9%

Osteoporosis 3.4%

Asthma Diagnosis 33.9%

Chronic Pain Diagnosis 39.8%*Heart failure, Angina or Myocardial Infarction; drugs for IHD drugs indistinguishable from drugs for hypertension

Alison Chisholm
These prevalence rates tie in with the defintiions on slide, i.e. asthma is ever before, sinusitis is read code ever and drugs in the last 2 years or read code in the last 2 years, etc.
Dermot Ryan
when: at outset or at end
Page 51: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Prevalence of comorbidities (II)• At the time of their COPD diagnosis:

– ~1/3 of patients been diagnosed with asthma at some point– Nearly 40% of patients had received multiple (≥3) prescriptions

for analgesics in the preceding 2 years– ~15% had been diagnosed with ischaemic heart disease in the

prior 2 years– ~16% had received medication for depression and/or anxiety in

the prior 2 years– ~18% of patients had comorbid diabetes

Page 52: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Active comorbidities over time (II)

• Prevalence of asthma remained steady at approximately 30%• Prevalence of all other active comorbidities increased over the 20 years of the

study (see table).

Year of COPD

diagnosis GERD

Depression and

AnxietySinusitis

Allergic rhinitis

Diabetes Mellitus

Ischaemic Heart

Disease

Osteo-porosis Asthma

Chronic Pain

1990 0.6% 7.4% 0% 4.0% 12.6% 6.5% 0.5% 33.4% 17.2%

1995 5.3% 11.9% 1.1% 7.7% 14.2% 13.2% 0.4% 38.7% 34.5%

2000 6.0% 15.4% 2.4% 6.5% 17.0% 16.7% 3.4% 36.0% 40.8%

2001 6.7% 16.8% 2.4% 6.7% 17.0% 17.8% 2.5% 32.7% 40.6%

2005 7.8% 17.2% 3.7% 5.9% 20.5% 16.0% 5.2% 33.2% 46.4%

2009 7.7% 14.6% 2.8% 7.0% 28.9% 11.5% 8.7% 31.0% 40.8%

p-value* <0.001 <0.001 <0.001 0.019 <0.001 <0.001 <0.001 <0.001 <0.001

*Chi squared

Page 53: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Active comorbidities by COPD severity at diagnosis (II)

FVC Ratio >=0.7 Mild Moderate Severe Very Severe.0

5.0

10.0

15.0

20.0

25.0

30.0

35.0

40.0

45.0

50.0

COPD Patients with Co-morbid Diagnoses by GOLD Severity

Asthma IHD Osteoporosis Diabetes Mellitus GERDRhinitis Sinusitis Depression Chronic Pain

GOLD Severity

Pe

rce

nta

ge

Page 54: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Conclusions• These data confirm that active comorbidities are common at the

time of COPD diagnosis.

• Trends over the study period suggest:– Constant diagnosis of asthma– Increased prevalence of active comorbidities– Association between presence of comorbidities and milder COPD at

time of diagnosis

• The increased prevalence of active comorbidities at the time of COPD diagnosis may indicate:– Increased awareness of comorbidities– Improved diagnosis of COPD in patients treated for comorbidities– Effects of national targets, e.g. UK Quality and Outcomes Framework.

Page 55: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Conclusions• Close monitoring of patients with existing conditions present opportunity

for earlier COPD identification and diagnosis.

• Decision support prompts: – Patients with a positive smoking history and either:

• IHD and/or

• Diabetes – should be evaluated for presence of COPD as part of their

reviews

• Integrated, holistic management of patients with COPD (≥GOLD II) is required to optimise care and minimse the morbidity and mortality of patients with COPD (e.g. reduce myocardial infractions and strokes for those COPD patients with comorbid IHD).

Page 56: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

QUESTIONNAIRES VS OPPORTUNISTIC SCREENING

Page 57: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Screening in primary care.

• Smoker + cough : – 27 % had COPD.– Have to test 4 patients to find one with COPD.

• Smoker + cough + 1 other risk factor: – 35 % had COPD– Must test 3 patients to find one with COPD.

C P van Schayck BMJ. 2002 June 8; 324 (7350): 1370

Page 58: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

So how should we do it?

Soriano J, Price D et al Lancet 2009

Page 59: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Can we target spirometry better in case finding?

Page 60: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Case finding questions– Age group (40-49, 50-59, 60-69, 70+)– Pack-years smoked (0-14, 15-24, 25-49, 50+)– Body mass index– “Does the weather affect your cough?” (Yes/No)– “Do you ever cough up phlegm [sputum] from your chest

when you don’t have a cold?” (Yes/No)– “Do you usually cough up phlegm [sputum] from your chest

first thing in the morning?” (Yes/No: negative association)– “How frequently do you wheeze?” (Ever/Never)– “Do you have or have you had any allergies?” (Yes/No:

negative association)

Page 61: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.
Page 62: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

COPD QuestionnaireQUESTION RESPONSE POINTS

What is your age? 40-49 years50-59 years60-69 years70 + years

048

10

How many cigarettes do you currently smoke each day (if you are an ex-smoker how many did you smoke)? What is the total number of years you have smoked cigarettes?Packs per day = cigarettes per day / 20 per packPacks-year = packs per day x years smoked

0-14 packs-year15-24 packs-year25-49 packs-year50+ packs-year

0237

What is your weight in kg? What is your height in m?BMI = weight / (height x height)

BMI <25.4BMI 25.4–29.7BMI >29.7

510

Does the weather affect your cough? YesNoI do not have a cough

300

Do you ever cough up sputum (phlegm) from your chest when you do not have a cold? YesNo

30

Do you usually cough up sputum (phlegm) from your chest first thing in the morning? YesNo

03

How frequently do you wheeze? NeverOccasionally

04

Do you or have you had any allergies? YesNo

03

Page 63: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Add up the total points based on the patient’s responses.• 17 or more points suggests a moderate to high risk of COPD:

go to COPD Diagnosis Guide .• 16 or fewer points suggest a low risk of COPD:

– consider other diagnoses, including asthma: proceed to the Adult Asthma Questionnaire

– or consider specialist referral.

Interpreting the COPD Questionnaire

- 16 17 18 19 +

Consider other diagnoses (proceed to the Adult

Asthma Questionnaire), or specialist referral

Proceed to COPD Diagnosis Guide

Page 64: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

SUMMARY

• Missed opportunities– In Primary Care

• CXRs rather than spirometry

– Secondary Care• Admissions – diagnosis

not being made effectively

• Opportunities– Use other CDM clinics to

identify patients– Educate staff doing

minor illness clinics– Use questionnaires– Use sophisticated

computer interrogation tools

• E.g OPC, GRASP, iCOPD

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SCN East of England

• IT tools – http://www.respiratoryfutures.org.uk/regions-and-nations/east-of-

england/announcements/summary-of-it-tools-to-support-respiratory-care-published-by-eoe-rscn-and-pcrs-uk/

• Our priorities with CCGs– Identify patients with COPD– Identify patients at risk of exacerbations– Set up respiratory pathways according to the

needs of their populations– Encourage an holistic approach to breathlessness

Page 66: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

The SCN breathlessness algorithm

Page 67: Missed Opportunities to Diagnose COPD D aryl Freeman on behalf of the Study Collaborators.

Questions?


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