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AGA Abstracts Mo1069 Addressing Low Colorectal Cancer Screening in African Americans: Focus Groups Reveal Insights for Developing an Effective Intervention Folasade P. May, Cynthia B. Whitman, Ksenia Varlyguina, Erica G. Bromley, Bibiana M. Martinez, Brennan M. Spiegel Background: African Americans (AAs) are disproportionately affected by high incidence and mortality from colorectal cancer (CRC). Although low screening rates amongst AAs have prompted efforts to increase uptake, previous interventions were rarely developed in concert with members of the AA community. In this study, we conducted focus groups with AAs to determine patient preferences for the content and mode of dissemination of culturally-tailored CRC screening interventions aimed at increasing screening uptake. Meth- ods: We recruited 45 to 75 year-old AAs from a large urban VA system and through Craigslist online advertisements. We divided participants into 4 focus groups, stratified by gender and CRC screening status. We used a semi-structured interview script employing open-ended elicitation and qualitative analysis software (ATLAS.TI) to code transcript data and group into a priori domains: barriers and facilitators to screening colonoscopy, sources of health and screening information, and preferred modes and content for CRC educational interventions. Results: We enrolled 38 AAs (mean age=54) into the 4 groups: screened AA males (n=7), unscreened AA males (n=6), screened AA females (n=12), and unscreened AA females (n= 13). Commonly reported barriers to colonoscopy included perceived invasiveness of the procedure, colon preparation, and financial concerns. Facilitators included poor diet/health and general desire to prevent CRC. Common sources of general health information included internet/television/radio, and medical providers. Information about colonoscopic CRC screen- ing was obtained most commonly from medical personnel or media sources. Consistent with this finding, media sources were the preferred mode of disseminating CRC screening information. Participants specifically suggested dissemination of information through com- mercials, billboards, influential personalities in the AA community, internet, and radio. AAs suggested future interventions include culturally specific information, including details about increased risk, accessing care, and the dispelling of myths. Participants also indicated their desire to receive information from their providers about all available CRC screening options rather than colonoscopy alone. Conclusions: Our findings inform the content and methods of dissemination of future public health interventions to improve CRC screening among AAs. Future interventions should utilize media outlets, emphasize increased risk among AAs, and address ethnic-specific barriers. The use of qualitative studies in implementation science assures that interventions will be appropriately patient-tailored. As healthcare reform extends health insurance options to patients who previously had limited access to care, it will be important to develop tailored interventions to maximize the uptake of newly accessible preventive services. Mo1070 Colorectal Health Disparities in a Government Healthcare System: a Retrospective Comparative Study Using Data From a A US Veterans Affairs Population Roopa Gandhi, John G. Muriithi, Ernest Wayde, Melinda Wayde, Salma Akram Background: Colorectal health disparities are a growing concern in the US. In 2010, the Patient Protection and Affordable Care Act was passed in the hope of providing access to healthcare for all Americans. The US Department of Veterans Affairs (VA) healthcare provides medical care with little or no financial barrier to veterans based on service connection and eligibility. Objective: The aim of our study was to determine colorectal cancer (CRC) stage at presentation and mortality in the Dayton VA healthcare system compared to a nationally representative sample - the Surveillance, Epidemiology, and End Results (SEER) program. Methods: We identified a cohort of 267 patients with a diagnosis of CRC from 2000-2010 at the Dayton VA Medical Center. The cohort was divided into copay exempt and copay- for- service groups. We compared age at diagnosis, stage of cancer, and one and five-year survival of each group to the national SEER database. Results: Total of 207 (78%) patients had private insurance or status that allowed for copay exemption, and 61 (22%) patients did not qualify for exemption. The average age at CRC diagnosis for all patients was 69 years. There was no statistical difference in number of patients diagnosed at each stage of cancer between the two groups. A Kaplan Meier was conducted to characterize survival among patients who were copay exempt and copay-for-service. The resulting curve showed no significant difference in five year survival between the two groups. In addition, the groups had no significant difference in five-year survival based on stage at diagnosis (Figure 2). Compared to the SEER data, our cohort had an overall lower five year survival when subgrouped by stage. Conclusions: Copay costs were not a predictor of later stage CRC at diagnosis, or a decreased survival. Our data supports that CRC stage at diagnosis has the most impact on overall survival. Figure 1- Cohort Survival Compared to SEER database *p=0.322, **p=0.791,***p=0.765 Figure 2- Five Year Survival Based on Stage at Diagnosis S-548 AGA Abstracts Mo1071 Colorectal Cancer Screening Rates in an Urban Ambulatory Clinic by Internal Medicine Residents Compared to the National Average; Identifying Barriers to Increased Colorectal Cancer Screening Manuel O. Gonzalez, Lilly M. Sadri, Alfred B. Leong, Smruti R. Mohanty, Parag Mehta Objective: Colorectal cancer (CRC) screening has proven to be a very effective tool in helping clinicians in detecting adenomatous polyps or colorectal cancer in its early stages. Despite having established CRC screening guidelines, national CRC screening rates vary between 54-75% of the at risk population depending on the screening rate in each state. An increased emphasis has been placed not only on educating the public but also in ensuring physicians in clinical training are educated on proper screening guidelines. Therefore, we investigated if an increased effort to improve internal medicine resident's education regarding CRC screening guidelines has resulted in improved CRC screening rates in an internal medicine outpatient medical resident clinic. The goal of this study is to compare our center's screening rate that to New York state average CRC screening rate and also to investigate the rate of screening among internal medicine residents based upon the level of training (PGY year I- III). Methods: We conducted a cross sectional study of patients who presented to the outpatient medical clinic of New York Methodist Hospital, Brooklyn, NY, over the span of six weeks. At the time the patient was being seen by their assigned medical residents, the patient filled out a questionnaire that collected demographics, data on the use of screening colonoscopy, fecal occult blood testing (FOBT), flexible sigmoidoscopy (FS), influenza vac- cine, screening mammography and screening Pap smears. The data capture was integrated as part of the medical interview by the resident. This data was collected at the end of the clinic visit and logged by a clinical investigator. Results: Four hundred and eighty three charts were reviewed. The CRC screening rates were as follows: 66% for PGY-1's, 72% for PGY-2's and 77% for PGY-3's; however no statistical difference was noted between the three groups (p < 0.05). The overall CRC screening rate at our institution was 72% which was not statistically different from the New York State average (p < 0.05). However there was a statistically significant increase in CRC screening rates in Hispanics (76%, p = 0.034) and in patients within the age range of 70-79 (82%, p = 0.015). Conclusions: Overall, when compared to NY State, patients that are followed by internal medicine residents at our urban outpatient teaching clinic did not receive higher rates of CRC screening nor did rates of screening vary with level of training (PGY year). There are several strategies that have been described in literature that have been shown to increase CRC screening rates by focusing on improved training of resident physicians, testing their knowledge of current screening guidelines, and introducing computerized prompts to help guide and remind the clinician of appropriate screening practices. Table 1. Study population breakdown. Table 2. Statistical analysis comparing our CRC screening rates to the 2010 New York State screening rates as determined by the CDC.
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Page 1: Mo1071 Colorectal Cancer Screening Rates in an Urban Ambulatory Clinic by Internal Medicine Residents Compared to the National Average; Identifying Barriers to Increased Colorectal

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Addressing Low Colorectal Cancer Screening in African Americans: FocusGroups Reveal Insights for Developing an Effective InterventionFolasade P. May, Cynthia B. Whitman, Ksenia Varlyguina, Erica G. Bromley, Bibiana M.Martinez, Brennan M. Spiegel

Background: African Americans (AAs) are disproportionately affected by high incidenceand mortality from colorectal cancer (CRC). Although low screening rates amongst AAshave prompted efforts to increase uptake, previous interventions were rarely developed inconcert with members of the AA community. In this study, we conducted focus groupswith AAs to determine patient preferences for the content and mode of dissemination ofculturally-tailored CRC screening interventions aimed at increasing screening uptake. Meth-ods: We recruited 45 to 75 year-old AAs from a large urban VA system and through Craigslistonline advertisements. We divided participants into 4 focus groups, stratified by gender andCRC screening status. We used a semi-structured interview script employing open-endedelicitation and qualitative analysis software (ATLAS.TI) to code transcript data and groupinto a priori domains: barriers and facilitators to screening colonoscopy, sources of health andscreening information, and preferred modes and content for CRC educational interventions.Results: We enrolled 38 AAs (mean age=54) into the 4 groups: screened AA males (n=7),unscreened AA males (n=6), screened AA females (n=12), and unscreened AA females (n=13). Commonly reported barriers to colonoscopy included perceived invasiveness of theprocedure, colon preparation, and financial concerns. Facilitators included poor diet/healthand general desire to prevent CRC. Common sources of general health information includedinternet/television/radio, and medical providers. Information about colonoscopic CRC screen-ing was obtained most commonly from medical personnel or media sources. Consistentwith this finding, media sources were the preferred mode of disseminating CRC screeninginformation. Participants specifically suggested dissemination of information through com-mercials, billboards, influential personalities in the AA community, internet, and radio. AAssuggested future interventions include culturally specific information, including details aboutincreased risk, accessing care, and the dispelling of myths. Participants also indicated theirdesire to receive information from their providers about all available CRC screening optionsrather than colonoscopy alone. Conclusions: Our findings inform the content and methodsof dissemination of future public health interventions to improve CRC screening amongAAs. Future interventions should utilize media outlets, emphasize increased risk amongAAs, and address ethnic-specific barriers. The use of qualitative studies in implementationscience assures that interventions will be appropriately patient-tailored. As healthcare reformextends health insurance options to patients who previously had limited access to care, itwill be important to develop tailored interventions to maximize the uptake of newly accessiblepreventive services.

Mo1070

Colorectal Health Disparities in a Government Healthcare System: aRetrospective Comparative Study Using Data From a A US Veterans AffairsPopulationRoopa Gandhi, John G. Muriithi, Ernest Wayde, Melinda Wayde, Salma Akram

Background: Colorectal health disparities are a growing concern in the US. In 2010, thePatient Protection and Affordable Care Act was passed in the hope of providing access tohealthcare for all Americans. The US Department of Veterans Affairs (VA) healthcare providesmedical care with little or no financial barrier to veterans based on service connection andeligibility. Objective: The aim of our study was to determine colorectal cancer (CRC) stageat presentation and mortality in the Dayton VA healthcare system compared to a nationallyrepresentative sample - the Surveillance, Epidemiology, and End Results (SEER) program.Methods: We identified a cohort of 267 patients with a diagnosis of CRC from 2000-2010at the Dayton VA Medical Center. The cohort was divided into copay exempt and copay-for- service groups. We compared age at diagnosis, stage of cancer, and one and five-yearsurvival of each group to the national SEER database. Results: Total of 207 (78%) patientshad private insurance or status that allowed for copay exemption, and 61 (22%) patientsdid not qualify for exemption. The average age at CRC diagnosis for all patients was 69years. There was no statistical difference in number of patients diagnosed at each stage ofcancer between the two groups. A Kaplan Meier was conducted to characterize survivalamong patients who were copay exempt and copay-for-service. The resulting curve showedno significant difference in five year survival between the two groups. In addition, the groupshad no significant difference in five-year survival based on stage at diagnosis (Figure 2).Compared to the SEER data, our cohort had an overall lower five year survival whensubgrouped by stage. Conclusions: Copay costs were not a predictor of later stage CRC atdiagnosis, or a decreased survival. Our data supports that CRC stage at diagnosis has themost impact on overall survival.Figure 1- Cohort Survival Compared to SEER database

*p=0.322, **p=0.791,***p=0.765Figure 2- Five Year Survival Based on Stage at Diagnosis

S-548AGA Abstracts

Mo1071

Colorectal Cancer Screening Rates in an Urban Ambulatory Clinic by InternalMedicine Residents Compared to the National Average; Identifying Barriers toIncreased Colorectal Cancer ScreeningManuel O. Gonzalez, Lilly M. Sadri, Alfred B. Leong, Smruti R. Mohanty, Parag Mehta

Objective: Colorectal cancer (CRC) screening has proven to be a very effective tool in helpingclinicians in detecting adenomatous polyps or colorectal cancer in its early stages. Despitehaving established CRC screening guidelines, national CRC screening rates vary between54-75% of the at risk population depending on the screening rate in each state. An increasedemphasis has been placed not only on educating the public but also in ensuring physiciansin clinical training are educated on proper screening guidelines. Therefore, we investigatedif an increased effort to improve internal medicine resident's education regarding CRCscreening guidelines has resulted in improved CRC screening rates in an internal medicineoutpatient medical resident clinic. The goal of this study is to compare our center's screeningrate that to New York state average CRC screening rate and also to investigate the rate ofscreening among internal medicine residents based upon the level of training (PGY year I-III). Methods: We conducted a cross sectional study of patients who presented to theoutpatient medical clinic of New York Methodist Hospital, Brooklyn, NY, over the span ofsix weeks. At the time the patient was being seen by their assigned medical residents, thepatient filled out a questionnaire that collected demographics, data on the use of screeningcolonoscopy, fecal occult blood testing (FOBT), flexible sigmoidoscopy (FS), influenza vac-cine, screening mammography and screening Pap smears. The data capture was integratedas part of the medical interview by the resident. This data was collected at the end of theclinic visit and logged by a clinical investigator. Results: Four hundred and eighty threecharts were reviewed. The CRC screening rates were as follows: 66% for PGY-1's, 72% forPGY-2's and 77% for PGY-3's; however no statistical difference was noted between the threegroups (p < 0.05). The overall CRC screening rate at our institution was 72% which wasnot statistically different from the New York State average (p < 0.05). However there wasa statistically significant increase in CRC screening rates in Hispanics (76%, p = 0.034) andin patients within the age range of 70-79 (82%, p = 0.015). Conclusions: Overall, whencompared to NY State, patients that are followed by internal medicine residents at our urbanoutpatient teaching clinic did not receive higher rates of CRC screening nor did rates ofscreening vary with level of training (PGY year). There are several strategies that have beendescribed in literature that have been shown to increase CRC screening rates by focusingon improved training of resident physicians, testing their knowledge of current screeningguidelines, and introducing computerized prompts to help guide and remind the clinicianof appropriate screening practices.Table 1. Study population breakdown.

Table 2. Statistical analysis comparing our CRC screening rates to the 2010 New York Statescreening rates as determined by the CDC.

Page 2: Mo1071 Colorectal Cancer Screening Rates in an Urban Ambulatory Clinic by Internal Medicine Residents Compared to the National Average; Identifying Barriers to Increased Colorectal

New York State screening rate was standardized to a base rate of .701 for comparison. Datawas analyzed by binomial statistical analysis. Statistical significance is defined as p lessthan 0.05.

Mo1072

Optimizing the Utilization of Adjuvant Chemotherapy Following SurgicalResection of Colon Cancer: A Comparison of Laparoscopic Versus OpenApproachBrian R. Englum, Paul J. Speicher, Asvin M. Ganapathi, Anthony Castleberry, Julie K.Thacker, Christopher R. Mantyh, John Migaly

Purpose Previous research has demonstrated that laparoscopic approach to colon cancerresection is a safe and potentially beneficial alternative to open surgery. Open colon cancersurgery has higher complication rates than laparoscopic surgery, which may delay chemother-apy for stage-specific tumors. Omission or delay in chemotherapy is known to significantlyimpact overall survival. In this study, we examine the use of appropriate adjuvant chemother-apy following open and laparoscopic surgery for colon cancer in a large national cancerregistry. Methods The National Cancer Data Base (NCDB) captures over 70% of cancer casesin the United States and provides detailed information on patient, tumor, and treatmentcharacteristics. Cases of colon cancer undergoing segmental or hemicolectomy with nodepositive disease in the NCDB from 2010-2011 were included in the analysis. Primaryoutcomes were use of any adjuvant chemotherapy and use of adjuvant chemotherapy within90 days of surgery. To adjust for non-random treatment selection, propensity adjustmentwith inverse probability weighting (IPW) was performed. Patient and tumor characteristicsbefore and after IPW adjustment were compared. Weighted logistic regression after IPWwas used to compare the association of laparoscopic and open surgery with the use ofadjuvant chemotherapy. Results From 2010-2011, 19,531 patients with colon cancer andpositive lymph nodes undergoing surgery were identified in the NCDB, with 12,088 patients(61.9%) undergoing open surgery and 7,443 (38.1%) treated laparoscopically. Patientsundergoing open surgery tended to have more comorbidities, larger tumors, higher clinicalT and N staging, and were more likely to be treated at community cancer programs (asopposed to comprehensive cancer centers or academic research programs); however, thesedifferences were minimized after IPW adjustment (Table). Before IPW, rates of adjuvantchemotherapy use were 62.3% for patients after open surgical resection, compared to 70.6%after laparoscopic surgery (p<0.001). After IPW, odds ratio (OR) for adjuvant chemotherapyuse was 1.27 (95% CI: 1.19-1.36) for laparoscopic versus open surgery, indicating thatpatients undergoing laparoscopic surgery were more likely to receive adjuvant therapy. Foradjuvant chemotherapy within 90 days of surgery, OR was 1.28 (1.20-1.36), again favoringa laparoscopic approach (Figure). Conclusion Patients undergoing laparoscopic surgery forpathologic stage III colon cancer had higher rates of adjuvant chemotherapy use and lowerrates of delay in chemotherapy initiation compared to those treated with open procedures,likely due to reduced complications from laparoscopic surgery. Further research will needto examine long-term outcomes in this population in order to understand the impact ondisease recurrence and long-term survival.Table. Preoperative patient characteristics by surgical approach before and after IPW adjust-ment

S-549 AGA Abstracts

N represents count (%) for each treatment group. Age represents mean +/- standard deviation(SD). All other values represent percentages. Other abbreviations are as follows: IPW -inverseprobability weighting, cm -centimeter, T stage -tumor stage, N stage -nodal stage.

Squares and error bars represent respectively point estimates and 95% confidence intervalsfor weighted odds ratio for use of indicated therapy after open versus laparoscopic coloncancer resection using inverse probability weighting (IPW).

Mo1073

Risk of Cold Snare Polypectomy for Small Colorectal Polyps in PatientsTaking the Antithrombotic AgentsAkira Horiuchi, Yoshiko Nakayama

Background: Antithrombotic agents are commonly used to prevent cardiovascular and cere-brovascular diseases. There are limited data on the risk of cold snare polypectomy fordiminutive colorectal polyps without discontinuation of antithrombotic agents. Objective:To evaluate the risk of postpolypectomy bleeding after removal of small polyps by coldsnare transection without electrocautery in patients taking antithrombotic agents. Method:An audit was conducted for a 1-year period of consecutive patients undergoing cold snarepolypectomy without discontinuation of antithrombotic agents. Patient demographics, num-ber, size, shape and location of polyps, the use of antithrombotic agents and postpolypectomy

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