Modeling Inflammation
Diana StefanAwanti Sambarey
August 12, 2012CSHL CCB Final Project Presentation
A healthy inflammatory response
Reduced model of inflammation• Kumar, R., Clermont, G., Vodovotz, Y., Chow, C.C., 2004. The dynamics of acute inflammation.
J. Theor. Biol. 230, 145–155.
•
m
l
pp = pathogenm = early pro-inflammatory mediatorl = late pro-inflammatory mediator
time
Reduced model of inflammation• Kumar, R., Clermont, G., Vodovotz, Y., Chow, C.C., 2004. The dynamics of acute inflammation.
J. Theor. Biol. 230, 145–155.
•
m
l
pp = pathogenm = early pro-inflammatory mediatorl = late pro-inflammatory mediator
time
Time course of p, m and l for the healthy response
Late
infla
mm
ator
y m
edia
tors
Persistent non-infectious inflammation
Exploring dynamics of the reduced model of inflammation
4
2
0
Persistent infectious inflammation
Severe immune deficiency
Recurrent infection
FP2
FP4
FP3
FP1
FP5
Kpm decreased
FP 5
FP 3
FP 4Healthy Oscillations Recurrent Infection
Kmp decreased
FP 2FP 3
Recurrent Infection Healthy Oscillations
Klm de
creas
edFP 5 Persistent NI Inflammation
Recurrent InfectionFP 3
FP 1
Healthy Oscillations
FP 4
Bifurcations
Pathogen Early Mediators Late Mediators
Anti-inflammatory Mediators
Extension of the model to account for anti-inflammatory mediators.
Kpm
M
M
Kmp
Healthy Oscillations
Recurrent Infection
Recurrent Infection
Healthy Oscillations
Concluding Remarks• The model examines the effect of the strength of early and
late-inflammatory responses, and describes the parameters that govern the clinical outcome.
• The addition of anti-inflammatory mediators prevents persistent non-infectious inflammation by regulating late mediators.
• The reduced model allows us to understand the general behavior of the system, however the model needs to be expanded to mimic the phenomenon of inflammation more closely.
Thank you!!