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ModuleB1:Growthandpuberty
Entry Scenario: The entry scenario addresses a variety of issues and problems associated with the module topic. It may be used at the beginning of the course to stimulate the students to identify their own needs and interests (see appendix 1). The results may be utilized by the individual to assess own learning process, or be integrated with class objectives. The 14.5 year-old boy David comes to clinic with his parents because the of stomach ache and headache since about 4 months. He does not like school. There is nothing unusual in the medical history. The growth curve drawn from school health service visits indicates growth in height along the 25th centile until age 12, at which time a failure in growth began. The boy’s height is now at the 3rd centile. A physical exam shows Tanner stages P1, A1, G2 with bilateral testicular volume of 5 ml. Weight is appropriate for height. The boy expresses concern about his delayed pubic hair and penile development because his teammates tease him in the showers after practice. The father ‘s height is 179 cm, the height of the mother 155 cm. Her menses began at age 15 years.
GeneralGoalsforLearnersBycompletingthemoduletheparticipantwillbeableto:I.Evaluateanadolescent’sgrowthstatusandpubertaldevelopmentincontextoftheirbio-psychosocialdevelopment,andcommunicatethefindingsandtheirsignificancetotheadolescentandtheparentsII.Identifydisordersofgrowthand/orpubertyandcausalconditions;initiatespecificdiagnosticassessmentsandtherapeuticmanagement
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GoalI.Evaluateanadolescent’sgrowthstatusandpubertaldevelopmentincontextwiththebio-psychosocialdevelopment,andcommunicatethefindingsandtheirsignificancetotheadolescentandtheparents
TrainingObjectivesKeytopicstobecovered
EducationalMethodology
Activities,Issues,andQuestions
Know.
A.Describephysicalchangesoccurringinthedifferentphasesofpubertyinbothsexesandcorrelatethesewithhormonalchanges,usingappropriatestandardsofcomparison(SeemoduleA1)-Tannerstaging,growthcharts(HYPERLINK=>Tannerstages/Pictures)-Principalendocrinechangesinadolescence-Genderdetermineddifferences-Othersexsteroideffects(eg.bonemineralization)-Averageages,upperandlowerlimitsofnormal
ReadingsInteractivelectureIndividual/groupwork
Lecturehighlightsphysicalmanifestationsindifferentphasesofpuberty,indicatingsuchdifferencesbetweengirlsandboysasfollows,TannerstagesB1-B3/G1-G3:obviousbreastbuddingandaccelerationofgrowth(girls)versusimperceptibleincreaseintesticularvolume(boys);TannerstagesB3-B4/G3-G4:menarcheatapreciseage(girls)versusmaturespermatogenesisatanon-preciseageandgrowthacceleration(boys).TannerstagesB4-B5/G4-G5:bodyfatincreaseandchangeindistribution(girls)versusvoicedeepening,facialhairandincreasedmusclemass(boys).Focusonnationalandinternationalgrowthchartsofbothsexes(incl.StandardDeviationScores(SDS).(HYPERLIKNK=>growthchart)Plotgrowthandpubertydataofanadolescentongrowthcharts;interprethormonaldataofanadolescentParticipantsdecideifthefollowingexamplesarewithinphysiologicallimitsofyoungpeopleofracial/ethnicgroupswithintheirowncountries/practices:
- Agirlwithpubichairdevelopmentbegunat7.5yrs/aboyat8.5years- Agirlwithbreastdevelopmentstartedat8.5yrs/aboywithtesticlegrowthstartedatage9.5years
- Agirlwithmenarcheat9.5years/aboywithspermarcheatage10.5- Agirlwithprimaryamenorrheaat15.5yrs/atall14yearoldboyG3/PH3withtesticlesof5mlsbothsides.
- A13.5yearoldgirlwithprepubertalbreastdevelopment(B1)/Aboywithprepubertalpenisat14yrs
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Attitude.
B.Describethetypicalcomplaintsandquestionsaboyorgirlmaymentionoraskthatshowconcernaboutgrowthandpuberty,andcomparethetwosexes.C.Identifyfactorswhichimpactonadolescent’sperceptionofthenormality/abnormalityofhisorherowngrowthandpubertaldevelopmentD.Identifytheimpactofearlyversuslatepubertyoncognitiveaffectiveandbehavioraldevelopment
FocusgroupIntroductoryshortlectureGroupdiscussionSmallgroupdiscussion
Listandrankbyorderoffrequencythequestionsorproblemsbroughtupbyfemaleandmaleadolescentsaboutgrowth,breastdevelopment(inbothsexes)andgeneralpuberty.Comparethetwosexes.
Lecturehighlightsthebiological,socialandmentaldevelopmentinearly,middleandlatestagesofadolescence(WHOcategories)usingApp.1ofmodule1andcomprehensivegrowthgraphic(App.1und2)Participantsformulateanddiscussexamplesinwhichaparticularcontextmayaffectanadolescent’sperceptionofheightandpubertaldevelopment(e.g.beingshorterortallerthanatwinbrother/sister;beingsimilartoashortparentwhodidordidnotaccepthis/herstature;beingnormalbut“short”relativetopeers;Usingnationalgrowthcharts/guidelinesofpubertaltiming.Discussthepotentialimpactofearly-normale–latepubertyinbothsexes.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251487/
Skill
E.Indicatehowtoobtainrelevantinformationongrowthandpubertyduringhistorytakingandphysicalexamination
Focusgroup
Groupsdeveloprecommendationsoninterviewingadolescentsforschooldoctorsresponsibleforroutinehealthvisits.Answersarecomparedandevaluatedduringplenarywithdiscussionabouttheissuesofcommunication,confidentiality/consentandcontexts(cultural,religious,etc.)
1. Should pubertal development be assessed and why? What are suitable conditions to do so? 2. What are the key questions to be used when taking a history from an adolescent boy or girl to evaluate pubertal development and the adolescent’s perception of it? 3. What are ways of respectfully assessing pubertal development through a physical examination?
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F.Demonstratehowtoexplainthefindingsongrowthandpubertytotheadolescentpatient,andhowtodescribewhatisnormalandwhatneedsfurtherclarification
Casestudyandroleplay
Casestudy:
Aboyof15complainsabouthisshortstature(3rdcentile)citingnegativeremarksfromthecoachofhisfootballteam.Yourfindings:targetheight(sex-correctedmid-parentalheight)at10thcentile;bornfulltermsmallat2.4kg;pubertystageP4G4;previousgrowthregularbetweenthe3rdand10thcentiles.Whenandhowdoyoucommentonthesefindings?
Someconsiderationsforusewithcasestudy(withattentionpaidinroleplaytotheuseofpropertimingduringinterview,andproperwordingtoaddresstheseissues):
• Heighthasafamilial/geneticcomponentthatdoesnotresultfromachoicebytheparentsnorbytheirchildren.
• Smallsizeatbirthmayalsoaccountforrelativelyshortheightlaterinlife.• Normalgrowthalonganormalcentileindicatesthatgrowthandsexhormoneareinorder.• Beingshortdoesnotpreventonefrombeingagoodathlete.• Treatmentmanipulationofgrowthisnotefficientandnotnecessarilysafeinsuchacase.
Casestudy:A 13.5 year-old boy consults for mild obesity (BMI +2.3 SD). Your findings: breasts (B3 appearance) with prominent fat and little true gynecomastia; testes are 5 ml but penis is still early-pubertal (G2) and partly hidden in pubic fat. How do you comment on these findings? Some considerations for case study:
• Fat tissue in excess may result in a breast-like appearance. • True glandular breast tissue does develop slightly but transiently during puberty in a majority of
normal boys. • Breast tissue does not indicate wrong sex orientation or wrong (female) hormones in blood. The
tissue may result from local transformation into estrogens of the increased male hormones produced by the testes.
• A hidden penis appears smaller than it is. • Increased testicular volume indicates that puberty just started and the signs of hormonal effects
(pubic hair, penile growth) are to be expected soon.
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• Being age 13.5 at such a stage corresponds to the lower limit of a normal range of 4 years between the fastest and slowest maturers.
Case Study: A 16 year old girl presents with B4, PH 4, no menarche, height at the 25th percentile, weight at the 3rd percentil,. She is very active in gymnastics. Some considerations for case study: Assess the amount of training intensity/hours and eating pattern. Examine growth curves for drops in weight and height. Consider laboraty tests of hormonal state (incl. Thyroidea) Consider female inner genital sonography Consider assessing bone age Consider smelling ability (Kallmann’s syndrome) Consider a chromosomal analysis Case Study: A 9.5 year old girl of African ethnicity is brought by her parents due to vaginal blood discharge. She is between B3-B4, PH3-4. She had a growth spurt in the last half year, breast budding started at age 8. The mother’s menarche was at age 10 Her height is at the 95th percentile, weight above 95th percentile. Some considerations for this case study: Know that this girl is within the normal range of puberty. Consider ethnic influences on pubertal development (HYPERLINK to to WHO charts: www.who.int/growthref/wn/) Examine growth charts and target height Discuss the influence of overweight on puberty Discuss the role of laboratory and radiographic work up.
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GOALII.Identifydisordersofgrowthand/orpubertyandcausalconditions;initiatespecificdiagnosticassessmentsandtherapeuticmanagement
TrainingObjectivesTopicstobecovered
Educationalmethodology
Activities,Issues,andQuestions
Know
A.Listcommonconditionswithgrowthand/orpubertalproblems,andrecognizetheirassociatedgrowthpatternsandetiologies.
- Familialshortstature
- Precociouspuberty- Intrauterinegrowthretardation
- Constitutionaldelayofpuberty
- Panhypopituitarism(craniopharyngioma)
- Turnersyndrome(non-limitinglist)B.Listtheessentialassessmentproceduresrequiredforanadolescentboyorgirlwithshortstatureand/ordelayedpuberty
Interactivelecture
Thelecturerliststhecommonetiologiesofshortstatureordelayedpubertyinadolescentboysandgirls,notingtheprominentfeatures.Participantsidentifyandjuxtaposetheconstitutionalversusnon-constitutionaletiologies(e.g.familialpubertaldelayvsKallmannsyndrome,idiopathiccentralprecociouspubertyvssexualprecocityinchildrenfrominternationaladoption,idiopathicGHdeficiencyvscraniopharyngioma,hypothyroidism).Participantsinterpretgrowthchartssuggestiveofthecommonconditions,andexplaintheirconclusions.
Case study: A girl of 14 consults because of her short stature. She had recurrent otitis in childhood, and occasional school problems. The exam indicates P3 B1. She has a mild dysmorphic appearance (short neck).
Definetheappropriateexaminationprocedures,includingothermedicalopinions,thatyouwouldrequestforanadolescentinwhomyoususpect
- Turnersyndrome- GHdeficiency
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- Kallmannsyndrome- Anorexianervosa
Whichspecialistswouldpossiblybeinvolved?
Attit.
C.Identifyreasonsfordiagnosticandtherapeuticinterventioninnon-specificdisordersofgrowthorpuberty
FocusgroupIndividualreflection,smallgroupdiscussion
Casestudy:Anadolescentboywithborderline(3rdcentile)shortstaturewhojustenteredpubertyattheageof14isreferredbyhisgeneralpractitioner.Examinationrevealsnospecificetiologicalcondition.Discuss:Whatcouldbereasonsforconsideringandproposingminimaldiagnosticassessment?What could be reasons for considering referral for therapeutic intervention? How would you counsel this boy with his serious concerns about his height? Discuss differences regarding the psycho-social impact on girls / boys with short/tall stature.
Skill
D.Demonstrateanabilitytoelicitfromanadolescentwithagrowth/pubertyprobleminformationaboutthepossibleinfluenceofsituationalfactors
Groupworkwithroleplay
ForObjectivesDandE,groupformulatesquestions(samplequestionsprovidedbelow)andusesthemtorole-playcasestudy.Casestudy:
A14yearoldgirlisseenatconsultation,forinadequatebreastdevelopment(B2-B3).Thefindings:pubichairP4;girlisinvolvedingymnastics10hours/week;mother’smenarchealage15years.Youtakeherhistory,payingattentiontouncoveringsituationalfactorsthatimpactthepatient’sfeelingsandcondition.Whatareasneedtobeconsideredinanassessmentofsituationalfactors?Forwhatpurpose?Usingwhichquestions?
Samplequestions:• Doesitbotheryouthatyourbreastshavenotdevelopedyet?Areyourparentsworriedaboutit?• Howdoyoufeelwhencomparedtoyourschoolmates?Ortoyourclassmatesingymnastictraining?• Doyoufeelhappyorpressuredbyyourgymnastictraining?• Howaboutyourheightandyourgrowth?Diditslowdownrecently?• Howdoyoufeelaboutthewayyourbodylooksrightnow?Howdoyoufeelwhencomparedtoyourclassmates?
• Whatdoesyourcoachthinkaboutyoursize?• Haveyoudoneanythingtotrytogainorloseweight?Dieting?Restrictingwhatyoueat?Intentionallyvomiting?
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E.Identifythepossiblecausesofgynecomastyandhowtoaddressit.Finvolvetheadolescentandthefamilyinthemanagementofthesituation
Groupworkwithroleplay
Casestudy:
• Aboyof15complainsaboutbreastdevelopment(B3)thatoccurredayearagoanddidnotchangeforthelast6months.Takehistoryincl.developmentofheightandweight.Assesscompletepubertaldevelopment(i.e.istesticledevelopmentcorrelatingwiththeotherTannerstages?Considerwork-upforKlinefeltersyndromifnecessary).Payattentiontoidentifyingconsequencesofhisproblem.Whatarehelpfulwaysofassessingandrespondingtoanadolescent’semotionallyloadedcomplaint?Usingwhichquestions/statements?
Samplequestionsforassessment:• Yourbreastdevelopmentstartedaboutayearago.Weretherechangesinyourlifeatthattime,orduringthepastyear?
• Doesthebreastdevelopmentbotheryou?Worryyou?Whendoesitbotheryouthemost?• Howdoyoufeelaboutitinrelationtoyourfriendsorclassmates?• Whatdoyouthinkabouttherestofthewayyourbodyisdevelopingandchanging?• Howislifeathome?Doyoufeelcoolornervous,aggressive?• Takinganymedicineonaregularbasis?• Smokingtobacco?Usinganydrugorsubstance?
Samplestatementsforresponse:• Icanunderstandyourconcern.• Thisisaverycommon,almostnormalproblemthatisbotheringyou,perhapsbecauseitisalittlemoreobviousthanusual.
• Itshouldresolvespontaneously,butitcantakemonthsorevenyears.• Ifyouarebotheredinthegymnasticclass,wecantalkaboutwhetheryou’dwantacertificateofexemption.
• Considerreferraltoanendocrinologistdependingontheadolescentdistress.
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FocusgroupRoleplay
Casestudy:Aboyaged14.5presentswithdelayedpuberty(G2P2,test.vol.5ml).Hehasschoolproblems(repeatedagrade)andexhibitssocialwithdrawal.Hewantstreatmentifpossible,buthisparentsarereluctant.Theywerealsolatebloomersandcouldmanagetheirliveswithouttherapy.Question:Whatkindofinformationshouldbeprovidedtofacilitatetheadolescentandfamily’sinputinthedecision-makingprocessregardingtherapy?Participantsformulateresponsesandpracticeinrole-play.
Guidelinestatements:• DPisnotadisease;itisanextremevariantofnormaldevelopmentandaself-limitingcondition.• DPdoesnotharmphysicallyandwillultimatelyresultinnormaladultdevelopmentandfunction(height,sexuality,fertility).
• DPmayharmpsychologically.• Insuchconditions,atreatmentmaybeusefulbecausetherearestillseveralmonthsoryearsofdelaybeforethegrowthspurt.
• Testosteronetherapyistransient,lastingfor6-12monthswiththeaimofattainingabloodleveloftestosteroneconsistentwithage.
• Thetreatmentwillaccelerategrowthandpubertaldevelopment(penilegrowth,pubichair)butwillnotchangethefinalheightanddevelopmentoutcome.
• Bothoptions(treatmentornotherapy)aremedicallyacceptableandsafe.• Giveprioritytotheadolescent’sopinion,whilelisteningtoandansweringtheparent’sconcernsandquestions.
• Whateverthepatient’sdecisionismaychangewithtimeanddevelopment.Thedecisionmightberevisedduringfollowup.
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Abb.1
Abb.2
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Resources
Adolescent Growth and Development - Virginia Cooperative Extension http://pubs.ext.vt.edu/350/350-850/350-850.html
Ohio State University Medical Center http://medicalcenter.osu.edu/patientcare/healthcare_services/mens_health/puberty_adolescent_male/Pages/index.aspx
Neinstein L. Puberty http://www.usc.edu/adolhealth
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Deborah Christie, Russell VinerAdolescent development. BMJ 2005; 330 doi: http://dx.doi.org/10.1136/bmj.330.7486.301 (Published 03 February 2005) http://www.bmj.com/content/330/7486/301