PharmacologyMolecular
A Publication of the American Society for
Pharmacology and Experimental Therapeutics
Volume 79 ■ Number 2 ■ February 2011 ■ ISSN 0026-895X
zmo0021100SPC1.qxd 1/6/11 12:46 PM Page 1
The best just got better.
The Microplate Reader Company
The FLUOstar Omega microplate reader
- now with extended UV/Vis absorbance range
HTRF is a registered trademark of Cisbio International.
LanthaScreen is a registered trademark of Invitrogen Corporation.
DLR is a trademark of Promega Corporation.
AlphaScreen and AlphaLISA are registered trademarks of PerkinElmer, Inc.
Transcreener is a registered trademark of BellBrook Labs.
The FLUOstar Omega is based on BMG LABTECH‘s Tandem Technology:
High-performance optical filters, plus an ultra-fast UV/Vis absorbance
spectrometer. The perfect solution for all your microplate based applications.
Absorbance Spectra from 220 to 1000 nm in 1s/well
Fluorescence Intensity: < 0.2 fmol / well Fluorescein
High-End Time-Resolved Fluorescence: < 3 amol / well Eu3+
Luminescence: 20 amol / well ATP
HTRF®, LanthaScreen® certified+, DLReadyTM
AlphaScreen®/AlphaLISA®, Transcreener® validated
Visit our website at www.bmglabtech.com
RANSCREENER™T ™
Can it be that simple?
Australia · Germany · France · Japan · United Kingdom · United States
Yes it can! SPECTROstar Nano - instantly capture a full
spectrum for low volumes, microplates and cuvettes
It is that easy with single push button operation and predefined protocols
for absorbance assays such as ELISAs, DNA, RNA, protein, cell growth, and
many more. Features of the SPECTROstar Nano include:
Ultra-fast UV/Vis spectrometer
Spectrum 220 - 1000 nm in <1 sec / well
Microplate formats up to 1536 wells
Cuvette port for standard and low volume cuvettes
Low volumes down to 2 μL
Automatic path length correction
Multimode shaking and incubation
Well scanning, kinetic and endpoint measurements
Gas vent for atmospheric sensitive samples
Powerful MARS Data Analysis Software
Robot compatible
DNA quantifi cation with SPECTROstar Nano
LVis Plate for low volume measurement
PFIZER POSTDOCTORAL PROGRAM IN NEUROSCIENCE Based in Groton, Connecticut, the Pfizer Neuroscience Fellowship Program provides an unparalleled opportunity for young scientists interested in understanding brain disorders and translating knowledge into innovative medicines. We seek motivated and enthusiastic individuals with a demonstrated track record in basic or translational neuroscience interested in pursuing an academic-style post-doc in an industry setting. Successful candidates will come from a range of backgrounds including molecular/cellular biology, protein biochemistry, in vitro and in vivo electrophysiology, imaging, neurochemistry, systems neuroscience, computational biology, animal models of disease, synapse biology and behavioral/cognitive neuroscience. Postdoctoral positions are available in the following disease areas:
Alzheimer’s disease and other dementias Autism Bipolar Disorder Depression
Huntington’s disease Parkinson’s disease Schizophrenia
Postdoctoral fellows will gain access to the resources, experience and collaborative industrial-academic network available within the Neuroscience Research Unit, conduct independent research, publish high profile papers on cutting edge areas of neuroscience, and attend and present at international scientific meetings. At the same time, postdoctoral fellows will contribute to Pfizer’s commitment to deliver new innovative medicines that effectively treat neurological and psychiatric diseases. Interested candidates can explore and apply for these competitive positions at www.PfizerNeuroscience.com. Applications are received and reviewed in the spring and fall. The deadline for spring applications is April 1st and for fall applications is October 1st. Fellowships are extremely competitive. We anticipate inviting a small number of candidates to interview in May and November at the Pfizer Groton Research Laboratories.
Where will your research lead?
Scientifically rigorous Cutting-edge content MI keeps you up to date
in all areas related to pharmacology
Professionally designed graphics are perfect for classroom use
EVERYONE should be reading MI!
Does your library subscribe to MMoolleeccuullaarr IInntteerrvveennttiioonnss?
ASK YOUR LIBRARY TO SUBSCRIBE TODAY!
No price increase for 2011: Institutional Online-Only Subscriptions are just $268
molinterv.aspetjournals.org
ASPET MembershipASPET Membership ASPET Membership Includes Online Access to:
Journal of Pharmacology and Experimental Therapeutics Pharmacological Reviews Molecular Pharmacology Drug Metabolism and Disposition Molecular Interventions (print subscription also included)
Members Save 50% on Page Charges and Color Fees $40/page for members versus $80 for nonmembers $200/color figure for members versus $400 for nonmembers Includes JPET, Molecular Pharmacology, and DMD Reduced Registration Fees for ASPET Meetings — Including Experimental Biology
Public Affairs Advocacy for Increased Research Funding and Science Policy Favorable to Biomedical Research — Public policy reports provided regularly
Personal print subscriptions are available only to ASPET members:
Journal of Pharmacology and Experimental Therapeutics - $220 Pharmacological Reviews - $89 Molecular Pharmacology - $180 Drug Metabolism and Disposition - $151 Prices are for 2011
Apply for membership online at aspet.org
9650 Rockville Pike, Bethesda, MD 20814-3995 [email protected] (P) 301-634-7060 (F) 301-634-7061
The Benefits Add Up!
Includes access to all archival issues back to volume 1, issue 1, of
each journal
The savings from one
article pay for a year’s dues
For ASPET Members
Only!
CLIENT NAME: Abelson TaylorJOB#: 14761DESC: MPI Research
OPERATOR: tjc
ROUND: 1DATE: 06/03/10
FILE NAME: I14761A1.indd QC Check __________
__________
__________
Bleed: 8.78” x 11.5”
Trim: 7.75” x 10.5”
Live: 7” x 9.75”
80 70 70 10010.2 7.4 7.4 100 100 100100 100 60 100 100 70 70 30 30 100 100 60 100 100 100 10070 70 30 30 100 100 60 70 70 4070 70 30 30 100 40 100 40 40 100 10 40 40 20 70 70 3.1 2.2 2.270 40 40 75 66 6650 40 4025 19 19B 0 0 0 0
100 70 30 100 10 25 50 75 90 100100 60 100 70 30 100 60 40 70 4070 30 100 40 40 100 40 100 40 70 40 70 40 40 340 70 40 70 40 40100 60A
3%ISO 12647-7 Digital Control Strip 2009
260-23515Pharm Exec, Contract Pharma,Science, DMD/JPET/MolPharm
™
Your responsive CRO partner,
delivering customized solutions and
adaptability to changing needs.
Preclinical research customized for you.
MPI Research is the CRO that defines responsiveness, moving your drug development program forward with customized solutions for all your preclinical research. From discovery services to safety evaluation, including analytical and bioanalytical support, you can count on MPI Research for quick quotes, frequent updates, rapid turnaround, and scientific rigor. At every stage, and on every level, we adapt to your most exacting needs.
Explore the breadth of capabilities that make us your responsive CRO at www.MPIResearch.com.